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Home , Dendrobine, Gelsemine, Harmine, Sinomenine, Toxiferine, Tutin (toxin)

Index

Acetone, 119 , (cont'd) (ACh), 36, 74-78, 81-83, 86- tubocurarine, 232-233 90, 117-119, 129, 130, 133-138, Alkaloid, natural, 101-105 144,157,158,163,282 Amanita muscoria, 192 antagonism to , 122 ,192 binding, 174 Amine interaction with d-tubocurarine, 125-126 BOL-148, 251, 253, 255,256,259-261 release, 134-136, 159, 161 , 251, 253, 258, 260, 261, structuralformula, 118 276,278 as a transmitter, 158 LSD-25, 251, 254-262, 268-284 Acetylcholinesterase, 107, 121, 159 lysergic acid, 250, 251, 268, 278 Acetyldihydrolysergamine, 253 , 251, 253, 261, 276 Acetyl-j3-methylcholine, 82, 87, 89, 160, , 251, 254, 259-262, 272, 161, 164 275,276,280,285 ACh, see Acetylcholine Amine, aromatic, 105-107 AChE, see Acetylcholinesterase structural formula, 106 Actomyosin, 80 Amine, biogenic, 7-35 Adenine nucleotide, 37-39 , 15-19 Adenosine monophosphate (AMP) release, 19-23 cyclic, 266, 267, 275 and reserpine, 7-35 dibutyryl, 266 retention, 19-23 Adenosinetriphosphate (ATP), 37-39 synthesis, 15-19 Adenyl cyclase, 267, 275 uptake, 19-23 Adlumia, 219 Amino acid Adlurnine, 220 basic, 189-191 Agarin, see L-a,y- Diaminobutyric acid, 189-190 Agene, see Nitrogen ~-N-methyl-L-a,~-diaminopropionic acid, Agroclavine, 250, 278 191 (-a,~-) Alkaloid, convulsant, 207-248 heterocyclic, 192-195 , 233-235 neurotoxic, 179-205 , 230-232 sulfur-containing, 195-197 biscuculline, 193, 215, 219-223 Amino acid alkaloids, 252 coniine, 233-235 ,),-Arninobutyric acid (GAB A), 36, 137, 195, cunaniol, 235 212,214,217,220-222,225-229, picrotoxinin, 222-230 232, 233 pilocarpine, 233-235 structural formula, 192 , 137, 208-218 ,),-Aminobutyric acid aminotransferase, 194

297 298 Index

4-Amino-3-hydroxyisoxazoline, see Cyclo• Belladonna, 157 Benadryl, 143 et-Amino-et-(3-hydroxy-5-isoxazolyl)acetic , 286 acid, see Benzoquinolizine, 26 5-Aminomenthyl-3-hydroxyisoxazole, see Benzpenicillin, 230-232 Muscimol structural formula, 231 Amitriptyline, 29 Betel nut palm, see Areca cathecu AMP, see Adenosine mono phosphate Bicucine, 223 , 23, 24 structural formula, 218 Ampicillin, 231 Bicucine methyl ester, 218, 219, 223 structural formula, 231 Biscuculline, 193, 215, 219-223 AMPT, see et-Methyl-p- and -y-Aminobutyric acid (GABA) Anectine, 108 antagonism, 222 Angiotensin, 77 chemistry, 219-220 Anticholinesterase, 133, 167 neuropharmacology, 220-223 Antidepressant, tricyclic, 29 structural formula, 218 Aplysia, 132, 164 Biscuculline diol, 219 Apo-fj-erythroidine, 138 structural formula, 18 , 275 Biscuculline methiodide, 221 Areca cathecu, 234 Biscuculline methochloride, 223 Arecoline, 233-235 structural formula, 18 structural formula, 234 Bis-quaternary compounds, 140-141 Arrow poison bis-carbaminoyl series, 141 curare as, 99-100 polymethylene series, 140-141 Ascaris, 131 Blockade, ganglionic Asclepias syriaca, 63 by , 77 Astacus armotus, 222 Blood pressure, 255 ATP, see Adenosinetriphospha te BOL, see D-2-Bromolysergic acid diethyl- , 157 amide , 75, 77, 81, 82, 87, 89, 138,143, , 75, 159, 160, 163 157-178,233,257,258 Brachioma, 131 action, 158-166 Bradykinin, 76, 77, 261, 262 at a distance, 162 Bretylium, 29, 163 intracellular, 164 structural formula, 27 postsynaptic, 158-159 2-Bromo-et-ergokryptine, 274, 278, 279 presynaptic, 159-163 and breast cancer, 280 binding, 164-165, 172 D-2-Bromolysergic acid diethylamide history, 157 (BOL), 251, 253, 255, 256, poisoning by, 167 259-261, 272-276 as a research tool, 168-175 , 209 tachyphylaxis, 165-166 action, 215-216 toxicology, 165-167 structural formula, 208 transport, 164-165 et-, 110, 121, 175 Atya, 131 Burn-Rand hypothesis, 11 Autoradiography, 144 of curare, 120-122

Caffeine, 40, 80 Baboon, see Papio papio Calabash alkaloids Barlow's model, 141 curarine, 121 Behavior and LSD, 269 , 121 Index 299

Calcium, 124 , 210-211, 216-217 pump, 24 structural formula, 209 storage, 24 Congo red Cambarus cillrkii, 222 and curare, 125 Caprinus atramentarius, 195 Coniine, 233-235 , 78, 120, 121 structural formula, 234 poisoning, 167 Convulsion, 180, 183, 185,186 Carbamylcholine, 82, 86, 160 C.O.P. Carotid structural formula, 210 body, 83 Coriaria japonica, 225 sinus, 83 Coriaria myrtifolia, 225 Catecholamine, 33, 254, 255 Coriamyrtin, 225, 230 depletion by reserpine, 14-15 structural formula, 224 and ergot, 260-261 Corlumine, 218, 220,223 and hyperglycemia, 265-266 Cortex, cerebral, 276 inhibition by reserpine, 32-33 Corydalis sewerzowi, 219,220 metabolism, 10 Crayfish, 130, 225 see Astacus, Cambarus precursor, 27-28 Cunaniol, 235 release, spontaneous, 22 structural formula, 234 storage, 11 Curare, 80, 99-156 synthesis, 19 acceptor, nonspecific, 113-114 Catechol-o-methyltransferase, 12 acetylcholine release, 134-136 Central nervous system (CNS), 41-42, action, mechanism of, 138-139 83-90 site of, 138-139 and curare, 137-138 Waser's model, 139-140 and ergot, 267-282 adsorption, 113 and nicotine, 83-90 antagonism and acetylcholine, 122 peripheral, see Peripheral nervous system as arrow poison, 99-100 and reserpine, 41-42 Boehm's classification, 101-102 Chemoreceptor calabash curare, 103 of carotid body, 83 and central nervous system, 137-138 Chick pea, 181 chemistry, 101-110 Chinese restaurant syndrome, 189 distrib.ution in body, 113 , 33, 38 elimination, 114-115 p-Chlorophenylalanine(PCPA), 270 excretion, 114-115 Chlorpromazine, 163 and release, 112 , 86 history, 100-10 1 Choline phenylether, 90 in motor axon terminals, 133-134 Chondodendron tomentosum, 101,232 as , 100 alkaloids from, 102-103 in muscle, skeletal, 122-128 Onanserine, 276 natural, 101-105 Qaviceps purpurea, 249 pharmacodynamics, 113-115 Clavine alkaloids pharmacology, 111-112 agroclavine, 250 pot curare, 102 elymoclavine, 250 , , 115-122, 130- ergolene, 250 134,136-145 Qibadium sylvestre, 235 postsynaptic, 129-130 CNS, see Central nervous system sources, 101-105 Cobrotoxin, 110 synthetic, 105-11 0 , 29 terminology, 10 1 structural formula, 27 toxicity, 111-112 300 Index

Curare-like agents, depolarizing, 126-127 Dihydroergostine, 259, 260 Curarine, 101-103, 121 Dihydroergotamine, 77, 254-267 structural formula, 104 Dihydroergotoxine, 256, 276 Cyanoamino acid, 191-192 Dihydro-/3-erythoidine, 76, 78, 89,90,104, /3-aminopropioni trile, 191-192 137,138,233 /3-cyano-L-, 191-192 Diisopropylfluorophosphate(DPF), 121 Cycas circinalis, 191 3,4-Dihydroxymandelic acid, 10, 12 Cycloserine, 194 3,4-Dihydroxyphenylalanine(L-DOP A), 10, structural formula, 192 16,27,270 Cystathionine, 196 1,1-Dimethyl-4-phenylpiperazinium, 78, 90 L-Cysteic acid, 196 Dimethyl-d-tubocurarine, 121, 138 L-Cysteine, 196 Diphenydramine, 143 structural formula, 195 DMPP, see Dimethylpiperazinium L-Cysteine sulfinic acid, 196 L-DOPA, see 3,4-Dihydroxyphenylalanine , 8-10, 27, 253, 270, 274-275, 277,282 DAB, see L-a,),-Diaminobutyric acid cerebral, 168 Dale's effect, 158 Dopamine-/3-hydroxylase, 9, 16, 18, 19, , 77, 80, 107,120,126- 33 128, 144, 145, 173 dTC, see d-Tubocurarine Decarboxylase, L-aromatic amino acid, 8 Duboisia hopwoodii, 63, 71 Delphinium crassifolium, 105 alkaloids from, 105 Demylation of spinal cord, 191 Eclipta alba, 63 , 225, 229 Edrophonium chloride, 124 structural formula, 224 Electrophorus, 129 Dendrobium nobile, 225 Electroplate, 129 Denervation supersensitivity, 73 Electroplax, 171, 174 2-DeoxY-D-glucose, 168 Elymoclavine, 250, 278 Depolarization, 76, 77,127 Emesis blockade, 73 and ergot, 276-277 by nicotine, 80 End-plate potential, 123 Desensitization, 117 e.p.p., see End-plate potential of receptor site, 127 Ephedrine, 75 Desmethylimipramine, 29 Epinephrine, 10, 31, 33, 163, 254, 260, structural formula, 27 261,263,265 DEP, see Diisopropylfluorophosphate uptake, 21 Diaboline, 216 Equisetum, 63 structural formula, 208 Ergocornine, 252,274, 277-280 L«,),-Diaminobutyric acid (DAB), Ergocristine, 252 189-190 Ergoethylergotamine, 263 structural formula, 190 Ergokryptine, 252, 255, 278 L-a,/3-Diaminopropionic acid, 182 Ergolene, 250 in Vicia baikalsensis, 183 Ergometrine, 251, 253, 258, 260, Dibenamine 261,276, 278 binding site, 174 Ergonine, 252 structural formula, 173 Ergoptine, 252 Dicentra cucullaria, 219,220 Ergosine, 252, 255 Dichloroisoprenaline, 265 Ergostine, 252, 259 Digena simplex, 194 Ergot alkaloids, 249-296 Dihydroergocornine, 255-258, 260 chemistry, 250-252 Index 301

Ergot alkaloids (cont'd) L- (cont'd) pharmacology, 252-282 structural formula, 180 central nervous system, 267-282 toxicity, 186-187 peripheral actions, 253-267 Glutamic acid decarboxylase, 194 on blood pressure, 255-256 synthetase, 197 on cardiovascular system, 255-263 , 208, 228, 229 on intestines, 254-255 and strychnine, 208, 212-215 on nerves, 256-258 Gonadotropin on uterus, 253-254 and ergot, 280-281 poisoning, 282-286 secretion, 280-281 acute, 282-284 "Goosestep" gait of cattle, 191 chronic, 284-285 Guanidine, 124 convulsive, 285 Guanidium, 163 fibrotic, 285 gangrenous, 284 , 252, 255, 256, 259, 261, Harmine, 4, 8 262,264,266,278,281 structural formula, 34 Ergovaline,252 Heart Erythrina, 139 and ergot, 255-263 alkaloids,from, 104, 138 Helix aspersa, 132, 222 Erythro-a-amino-a-(3-oxo-5-isoxazolidinyl)• Hemicholinium, 160 acetic acid, 194 Hemlock, 234 ,6-Erythroidine, 104, 127, 137 Heparine, 114 structural formula, 104 , 75-78, 81-83, 89, 90, Eserine, 109, 124, 133, 134, 160, 161, 125,173 168,258 Hirudo, 131 Eye movement, rapid (REM), 271, 272 Histamine, 35-36 depletion, 36 release by curare, 112 Fibrosis, inflammatory, 285 , 36 Flaxedil, 105, 127 Homarus, 131 structural formula, 106 DL-Homocysteic acid, 196 Fluorocurarine, 103 DL-Homocysteine, 196 Fly agaric, 192 L-Homocysteine structural formula, 195 Homoserine, 196 GABA, see 'Y-Aminobutyric acid , 168 Galactorrhea, 279 Hormones Gallamine, 88, lOS, 138 and ergot, 277-281 structural formula, 106 Hydergine, 252, 259, 260, 263, 281 Ganglion cell, autonomic, 129, 265 (-)-,6-, 220 , 211, 217 12-Hydroxyergometrine, 276 structural formula, 210 5-Hydroxyindoleacetic acid, 12, 13 sempervirens, 211,217 4-Hydroxystrychnine, 216 Gland, pineal, 12 5-Hydroxytryptamine(5-HT), 12,27, 31, L-Glutamic acid, 36, 185-189 193, 195,235,253, 254, 261, action, mechanism of, 187-189 263, 268-282 biochemistry, 185-186 degradation, 13 chemistry, 185-186 and ergot, 261-263 in glial cells, 197 structural formula, 34 and spreading depression, 188 synthesis, 13 302 Index

5-Hydroxytryptophan, 13, 27, 28 Leptocurare, 110, 126, 127 Hyoscyanine, 160 Lesion, gastric, 35 Hyperactivity, 183 , 209, 217 Hyperglycemia, 265 LGN, see Nucleus, lateral geniculate Hyperthermia Lipid and LSD, 281 and ergot, 266 metabolism, 266 Lonicer(1582) IAA, see -4-acetic acid IB, see o-Iodosobenzoate mentioning ergot, 249 Ibotenic acid, 193 LSD, 251, 254-262, 268-284 structural formula, 192 Lumbricus, 131 Imbretil, 108, 109 Lycopodium, 63 Imidazole-4-acetic acid (IAA), 195 Lysergic acid, 250, 251, 268, 278 structural formula, 192 and behavior, 269 , 29 and sleep, 269 Induction, transsynaptic, 18 Insect, 132 Intocostrin, 102 Malapteruus, 129 "Inversion point" phenomenon, 259 , 83, 87-90 o-Iodosobenzoate (IB), 120, 126 Medulla, adrenal, 11-12, 16 "potentials," 120 , 12, 13 , 8, 28 , 10 structural formula, 27 Metaraminol, 23, 25, 31 1757 I.S. structural formula, 24 structural formula, 210 Methacholine,? 8 1762 I.S. Methergoline, 254 structural formula, 210 Methionine sulfoxime, 196-197 Isoquinoline, 105 structural formula, 195 structural formula, 106 3-Methoxy-4-hydroxymandelic acid, 10 3-Methoxy-4-hydroxyphenylglycol, 10, 12 Junction, neuromuscular, 79-81 N-Methylbicuculleine, 219, 221 and nicotine, 79-81 structural formula, 210 ~-N-Methyl-L-o<,~-diaminopropionic acid, 191 L-a-Kainic acid, 194 structural formula, 190 structural formula, 192 o<-Methyldopamine, 8 7-Keto~-dehydrothebaine methyl enolate, I-Methylelymoclavine, 254 see Methylergometrine, 251, 253, 261, 276 Khromov-Borisov model, 142 I-Methylergostine, 259 Kinin, 261, see also Bradykinin I-Methylergotamine, 259, 262, 263 o<-Methylnorepinephrine, 23, 25 Langley's work on nicotine, 69-73 structural formula, 24 Lathyrism, 181 1-Methyl-2-(3-pyridyl)pyrrolidine, see experimental, 181 Nicotine in India, 181 Methyl reserpate, 6 Lathyrus, 189 o<-Methyl-p-tyrosine (AMPT), 8, 270, 281 L. odoratus, 181, 191 Methysergide, 251, 254, 259-262, 272, L. sativus, 181 275, 276, 280, 285 L. sylvestris, 190 Metubine, 103 , 211, 217 Michelson model, 142 structural formula, 210 Microelectrophoresis, 87, 125-126 Index 303

Migraine, 261-263, 285 Nicotine (cont'd) and ergot, 261-263 pharmacology, 68-90 etiology, 261 action, mechanism of, 73-90 treatment, 262 history, 69-73 Mitochondrion, 40-41 toxicology, 64-68 Mold , 192 uses, 63-64 Monoamine, 253 and vomiting, 84 , 8, 12 Nitrogen chloride, 196 inhibitor, 8, 16,26,28-29,275 Agene, 196 Monosodium L-glutamate, 185 in wheat, 196 Chinese restaurant syndrome, 189 Noradrenaline, 86 occurrence, 185 , 8, 10-12, 18, 20, 23, 163, , 160, 210-211, 216 253,255,261,263-265,267,269, structural formula, 209 270,275,278,282 Motor axon terminal structural formula, 34 and curare, 133-134 , 10 Mucopolysaccharide, acidic Nornicotine, 63 and curare, 120 NTS, see Nucleus tractus solitarius , 75, 82, 192 3',5'-Nucleotide phosphodiesterase, 39 Muscarone, 120, 121 Nucleus binding, 174 lateral geniculate, 273 Muscazone, 193 tractus solitarius, 271, 277 Muscimol,193 structural formula, 192 Muscle cell, invertebrate, 129-130 Octopamine, 23 Mushroom toxin, 192 structural formula, 24 Mytilus, 132 ODAP, see ~-N-Oxalyl-L-a,J3-diamino- Mytolon, 134 propionic acid Organ, electric, 129 poisoning, 167 , 124, 134, 141 Osteolathyrism, 181 Nerve Oxalyl-coenzyme A, 182 adrenergic sympathetic, 256-257 !3-N-Oxalyl-L-ar,~-diaminopropionic acid cell, invertebra te, 129-130 (ODAP),180-185 cholinergic sympathetic, 257-258 action, mechanism of, 183-184 fiber, afferent, 82 chemistry, 181-182 terminal, 81-83 metabolism, 182 Neurolathyrism, 180, 181 occurrence, 182-183 , 9, 12,13, 183,187 toxicity, 183 Nicergoline, 261 o-Oxalylhomoserine, 182 Nicotiana, 62-63 Oxotremorine, 160, 161 N. rustica, 63 N. suaveolens, 63 N. tabacum, 63 PBZ, see Phenoxybenzamine Nicotine, 61-97,137, 173 PCP A, see p-Chlorophenylalanine as antihelminthic, 65 Pachycurare, llO, 127 assay, 62 Pancuronium dimethobromide, 110 central nervous system, 83-90 Pantherin, see Muscimol chemistry, 61-62 , 211 occurrence, 62 Papio papio by, 70 photosensitivity and LSD, 274 304 Index

Paralysis, neuromuscular, 78 Prolactin (cont'd) Parathion poisoning, 167 release factor(PRF), 277 , 8 secretion, 277-280 Pathway, muscarinic, , 40, 282 absence, 168-170 E!,264

presence, 168-175 E 2 ,264

Paton's rate theory, 72,80-81 F 2 0!, 168 Protocurarine, 102 as GAB A antagonist, 232 , 262 therapy, 231 Psychopharmacology, 41 Penicillium chrysogenum, 230 PTMA, see Phenyltrimethylammonium Pentamethonium, 78 pyridoxime-2-aldoxime chloride, 167 Pentamethoniuin iodide, 107 pyrrolidine-2-carboxylic acid, see L-a-Kainic Pentobarbitone, 217 acid Pepsin, gastric, 168 Peripheral nervous system, 42-43, 263-265 Quantum content of potential, 162 Periplaneta americanum, 131,222 Quinine, 105 PGO spiking phenomenon, 272 Quinine methochloride, 105 Phenolamine, 268 , 105 , 286 structural formula, 106 Phenoxybenzamine(PBZ), 258, 263, 264 Phenyltrimethylammonium, 78 Ranvier's node, 133, 134 Phosphodiesterase, 275 Rauwolfia serpentina, 1-2 Phosphorescence, 62 action, antihypertensive, 1 Phosphorylase a, 40 psychotic, 1 Phthalide isoquinoline alkaloids, 220 Receptor activator Physostigmine, 75, 86, 124 cholinergic, 115-122, 130-134, 138-145 Picrotin, 223, 229 activation, 117 structural formula, 224 autoradiography, 120-122 Picrotoxinin, 222-230 binding site, 11 7 -119 chemistry, 223-225 chemical nature, 119-120 neuropharmacology, 225-230 classification, 115-116 structural formula. 224 and curare, 138-145 PIF, see Prolatin, inhibiting factor desensitization, 117 Pilocarpine, 233-235 topography, 116-117 structural formula, 234 muscarinic, 158 Pilocarpus microphyllus, 234 nicotinic, 119-120 Pimozide, 274 postsynaptic Piperidine, 107 and curare, 129-130 Pituri,71 Receptor density, 143-145 Polyporus sulfureus, 195 Receptor site Polysulfonate, 114 Barlow's model, 141 Pot curare, 102 Khromov-Borisov and Michelson model, Prelease, 279 142 Pressure receptor Rybolovlev's model, 141-142 of carotid sinus, 83 REM, see Eye movement, rapid PRF, see Prolactin, releasing factor Renshaw cell, 87-89, 138, 159 Procaine, 164 Reserpic acid, 6 Procambarus, 131 Reserpine, 1-60, 270 Prolactin action, mechanism of, 29-35 release, inhibiting factor (PIF), 217 site of, 21-22 Index 305

Reserpine (cont 'el) Sinomenine, 217 affective disorder, 46 SKF 525-A, 114 binding, 4-7 Sleep, slow-wave, 271 botany, 3 Storage vesicle, adrenal, 30-35, 38 and cardiovascular system, 43, 46 Strychnine, 137, 208-218 and catecholamine, 32-33 and 'Y-Aminobutyric acid (GABA), 212, depletion, 7 214 and cations, 39 chemistry, 208-211 and central nervous system, 41-42 convulsion, 211 chemistry, 3 and glycine, 208, 212-215 depression, mental, 45-46 neuropharmacology, 211-215 disorder, affective, 46 structural formula, 208 psychiatric, 45-46 Strychnos diaboli, 216 distribution, 4-7 S. ignatii, 208 effect, biochemical, 35-41 S. mux-vomica, 208 pharmacological, 41-45 S. toxi/era, 102-104 and endocrine system, 44-45 Succinylcholine, 77, 80, 82, 88,107,109, excretion, 4-7 127,144 flrst tranquilizer, 41 deriva tives, 109 and gastrointestinal system, 43-44 structural formula, 108 history, 1-3 Sucrose gap technique, 130 mental depression, 45-46 SWS, see Sleep, slow-wave metabolism, 4-7 Sympathectomy, chemical, 15 and peripheral nervous system, 42-43 Syncurine persistence, 4-5 structural formula, 108 pharmacognosy, 3 S yringic acid, 6 poisoning, 46-47 Syringol methyl reserpate, 6 psychiatric disorder, 45-46 depletion, 7 structural formula, 2, 3, 6, 34 , 157 synthesis, 3 Taenia coli, 255 toxicity, 45-47 TEA, see Tetraethylammonium tranquilizer, flrst, 41-42 TensiIon, 124 uses, clinical, 45-47 Tetrabenazine, 26-27, 270 Respiration structural formula, 27 and ergot, 277 Tetraethylammonium (TEA), 107, 139 Rybolovlev's model, 141-142 Tetrahymena, 40 Rye, see Secole cereale Tetramethylammonium, 76, 78, 86, 139 , 159, 161, 188 Sabellastarte, 131 , 21-211, 216 poisoning, 167 structural formula, 209 Sclerosis, amyotropic lateral, 191 Theophyllin, 266 on Guam, 191 Thermoregulation , 167, 173 and ergot, 281-282 Sebacinylcholine, 109, 141 Thiopental, 4 Secole cereale, 249 Thyrotropin releasing factor (TRF), 278 Sedum acre, 63 L· Thyroxine, 190 Serine hydroxymethyltransferase, 194 , 64-67 Serotonin, see 5-Hydroxytryptamine smoke, 89-90 Shikimin, 230 Tolerance, acute, 165-166 structural formula, 224 Torpedo, 129,174 306 Index

Toxiferine, 101, 103, 121, 128 , 18, 23 structural formula, 104 structural formula, 24 Transmission, cholinergic Tyrosine, 8, 10 in invertebrates, 131-132 , 8, 17, 18 Transmitter, 158 false, 23-26 Transphosphorylation, 31 Ulcer, gastric , 8 and reserpine, 43 Tremor, 78 Urecholine, 164 TRF, see Thyrotropin releasing factor Uterus Tricholoma muscarium, 194 and ergot, 253-255 Tricholomic acid, 194 3,4,5-Trimethoxybenzoic acid, 6 , 26, 263, 271 Vagusstoff, 157 , 12, 13, 275 Venus, 132 , 12 Vicia, 190-191 Tubocurare, 101 V. baikalensis, 183 Tubocurarine, 76-78, 82, 101,102,111, Vomiting, see Emesis 122,128,130,133-138,142, 145,165,232-233 d-tubocurarine, 102-103, 125-126 Waser's autoradiography, 144 I-tubocurarine, 103 Waser's model of curare action, 139-140 (+)-Tubocurarine dihydrochloride, 231-233 Wedensky inhibition, 128, 135 , 225, 229 W-G aldehyde, see Wieland-Guemlich structural formula, 224 aldehyde "Tutu" , 225, 229 Wieland-Guemlich aldehyde, 208