a K99E.coli type Cfraction. stimulated bytheCl.perfringens ScourGuard 4KCdidnotinterferewiththeprotectiveresponse 4KC wasdemonstratedbyshowingtheotherfractionsof type CcomponentofScourGuard Efficacy oftheCl.perfringens died within48hoursofchallenge. 100% ofcalves(88)receivingcolostrumfromcontrolcows E. coli fractionofScourGuard4KCwereprotected.Incontrast, receiving colostrumfromcowspreviouslyvaccinatedwiththe previous studies.Followingchallenge,95%ofcalves(1920) demonstrated inanadditionalstudy,designedsimilarlytothe Efficacy oftheE.coli consuming colostrumfromcontrolcows. attitude anddehydrationscoreswhencomparedtocalves had significantreductionsinmortalityandabnormalappetite, challenge, calvesthatreceivedcolostrumfromvaccinatedcows fraction containedinScourGuard4KCoraplacebo.Following trum obtainedfromheiferspreviouslyvaccinatedwiththeBCV removed fromtheirdamspriortonursingandwerefedcolos 4KC wasdemonstratedinachallengestudy.Calveswere Efficacy ofthebovinecoronavirus(BCV)fractionScourGuard consuming colostrumfromcontrolcows. attitude anddehydrationscoreswhencomparedtocalves showed significantreductionsinabnormalfecal,appetite, calves fedcolostrumfromScourGuard 4KC-vaccinatedheifers placebo. WhenchallengedwitheitherBRVserotypeG6orG10, heifers previouslyvaccinatedwitheitherScourGuard4KCora dams priortonursing,andwerefedcolostrum Zoetis Inc.Healthyneonatalcalveswereremovedfromtheir 4KC wasdemonstratedin2challengestudiesconductedby Efficacy ofthebovinerotavirus(BRV)fractionScourGuard type Cincalvesofvaccinateddams. and Cl.perfringens rotavirus (serotypesG6andG10),bovinecoronavirus,E.coli ­effective asanaidinpreventingdiarrheacausedbybovine EFFICACY: ScourGuard4KChasbeendemonstratedtobe vaccine isadjuvantedtoenhancetheimmuneresponse. and G10)corona liquid preparationofinactiva type C.ScourGuard4KCcontainsa Clostridium perfringens Escherichia colihavingtheK99piliadherencefactor,and G6 and G10),bovinecoronavirus,enterotoxigenicstrainsof diarrhea intheircalvescausedbybovinerotavirus(serotypes of healthy,pregnantcowsandheifersasanaidinpreventing PRODUCT DESCRIPTION:ScourGuard4KCisforvaccination ScourGuard Bacterin-Toxoid Type C-EscherichiaColi Clostridium Perfringens Killed Virus Coronavirus Vaccine Bovine Rotavirus- type Ctoxoid.The bacterin, andCl.perfringens ­virus propagatedonestablishedcelllines, K99fractionofScourGuard4KCwas ® 4KC ­ted bovinerotavirus(serotypesG6 ­collected from 30243700

­ Kalamazoo, MI49007,USA Zoetis Inc. U.S. Veterinary LicenseNo.190 For veterinaryuseonly Veterinary Services, (888)963-8471(USA),(800)461-0917(Canada). Technical inquiriesshouldbedirectedtoZoetisInc. is notadministeredinaccordancewithlabeldirections. conditions, areotherwiseimmunocompromised,orthevaccine or parasitized,arestressedduetoshipmentenvironmental animals areincubatinganinfectiousdisease,malnourished animals. Aprotectiveimmuneresponsemaynotbeelicitedif This producthasbeenshowntobeefficaciousinhealthy with appropriatesupportivetherapy. antidote ofepinephrineisrecommendedandshouldbefollowed As withmanyvaccines,anaphylaxismayoccurafteruse.Initial tion. Transient temperatureincreasesmayoccurfollowingvaccina- Contains gentamicinandmerthiolateaspreservatives. Do notvaccinatewithin21daysbeforeslaughter. vaccine. Sterilized syringesandneedlesshouldbeusedtoadministerthis Use entirecontentswhenfirstopened. adversely affectpotency.Donotfreeze. Store at2°–7°C.Prolongedexposuretohighertemperaturesmay PRECAUTIONS: including annualrevaccination,shouldbeemployed. Good animalhusbandryandherdhealthmanagementpractices, before eachsubsequentcalvingisrecommended. Revaccination: Revaccinationwithasingledose3–6weeks 3–6 weeks beforecalving. 3 weeks aparttopregnantcows,withtheseconddosegiven Primary Vaccination:Administer2IMdosesapproximately muscular regionoftheneck. Assurance guidelines,thisproductshouldbeadministeredinthe 2 mL intramuscularly(IM)only.InaccordancewithBeefQuality heifers isrecommended.Shakewell.Asepticallyadminister General Directions:Vaccinationofhealthy,pregnantcowsand DIRECTIONS: ScourGuard 4KC. events wereobservedinvaccinatesfollowingadministrationof in 3 differentgeographiclocations.Nosignificantadverse heifers wasdemonstratedin3fieldsafetystudiesconducted SAFETY: ThesafetyofScourGuard4KCinpregnantcowsand 30243700

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Project No. Artwork Number Description Country 12693 30243700 ScourGuard US Dimensions Drawing No. SKU No. Item 3.5” x 9” (folds to 3.5” x 2.25”) 5243000 Insert Additional Info: Colors: EDITOR’S COPY Black Dieline GS: DATE:

Mgr J. Rustad Rev GA PR GS / ART REV (LCA) GS / ART REV (FA) GS C. Teachout CHANGES CHANGES CHANGES 1 GA S. Lewis OK OK OK