JOURNAL OF VIROLOGY
Volume 84 April 2010 No. 8
SPOTLIGHT
Articles of Significant Interest Selected from This Issue by 3729 the Editors
STRUCTURE AND ASSEMBLY Low pH-Induced Conformational Change in Herpes Simplex Stephen J. Dollery, Mark G. 3759–3766 Virus Glycoprotein B Delboy, and Anthony V. Nicola The Pre-S2 Domain of the Hepatitis B Virus Is Dispensable Yi Ni, Jessika Sonnabend, Stefan 3879–3888 for Infectivity but Serves a Spacer Function for L-Protein- Seitz, and Stephan Urban Connected Virus Assembly Analysis of a Charge Cluster Mutation of Herpes Simplex Richard J. Roller, Susan L. Bjerke, 3921–3934 Virus Type 1 UL34 and Its Extragenic Suppressor Suggests Alison C. Haugo, and Sara Hanson a Novel Interaction between pUL34 and pUL31 That Is Necessary for Membrane Curvature around Capsids
GENOME REPLICATION AND REGULATION OF VIRAL GENE EXPRESSION Role of the IE62 Consensus Binding Site in Transactivation Kris White, Hua Peng, John Hay, 3767–3779 by the Varicella-Zoster Virus IE62 Protein and William T. Ruyechan Inhibition of Herpes Simplex Virus Type 1 Replication by Daniel L. Glauser, Michael Seyffert, 3808–3824 Adeno-Associated Virus Rep Proteins Depends on Their Regina Strasser, Marco Franchini, Combined DNA-Binding and ATPase/Helicase Activities Andrea S. Laimbacher, Christiane Dresch, Anna Paula de Oliveira, Rebecca Vogel, Hildegard Bu¨ning, Anna Salvetti, Mathias Ackermann, and Cornel Fraefel
GENETIC DIVERSITY AND EVOLUTION Host Range, Prevalence, and Genetic Diversity of Yan Li, Xingyi Ge, Huajun Zhang, 3889–3897 Adenoviruses in Bats Peng Zhou, Yan Zhu, Yunzhi Zhang, Junfa Yuan, Lin-Fa Wang, and Zhengli Shi Species-Specific Inhibition of Foamy Viruses from South Beatriz Pacheco, Andre´s Finzi, 4095–4099 American Monkeys by New World Monkey TRIM5␣ Kathleen McGee-Estrada, and Proteins Joseph Sodroski
VIRUS-CELL INTERACTIONS Macrophage Receptors for Influenza A Virus: Role of the Jacqueline P. Upham, Danielle 3730–3737 Macrophage Galactose-Type Lectin and Mannose Receptor Pickett, Tatsuro Irimura, E. Margot in Viral Entry Anders, and Patrick C. Reading Human Herpesvirus 7 U21 Downregulates Classical and Nathan A. May, Nicole L. Glosson, 3738–3751 Nonclassical Class I Major Histocompatibility Complex and Amy W. Hudson Molecules from the Cell Surface Bimolecular Complementation Defines Functional Regions Doina Atanasiu, J. Charles 3825–3834 of Herpes Simplex Virus gB That Are Involved with gH/gL Whitbeck, Manuel Ponce de Leon, as a Necessary Step Leading to Cell Fusion Huan Lou, Brian P. Hannah, Gary H. Cohen, and Roselyn J. Eisenberg The ORF3 Protein of Hepatitis E Virus Delays Degradation Vivek Chandra, Manjula Kalia, 3857–3867 of Activated Growth Factor Receptors by Interacting with Krishnan Hajela, and Shahid Jameel CIN85 and Blocking Formation of the Cbl-CIN85 Complex
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Lentiviral Nef Proteins Utilize PAK2-Mediated Deregulation Bettina Stolp, Libin Abraham, 3935–3948 of Cofilin as a General Strategy To Interfere with Actin Jochen M. Rudolph, and Oliver T. Remodeling Fackler A Novel Inhibitor of the NF-B Signaling Pathway Encoded D. G. Diel, G. Delhon, S. Luo, E. F. 3962–3973 by the Parapoxvirus Orf Virus Flores, and D. L. Rock Human Rhinovirus 14 Enters Rhabdomyosarcoma Cells Abdul Ghafoor Khan, Angela Pickl- 3984–3992 Expressing ICAM-1 by a Clathrin-, Caveolin-, and Flotillin- Herk, Leszek Gajdzik, Thomas C. Independent Pathway Marlovits, Renate Fuchs, and Dieter Blaas Herpes Simplex Virus Glycoproteins H/L Bind to Cells Tatiana Gianni, Arianna Cerretani, 4013–4025 Independently of ␣V3 Integrin and Inhibit Virus Entry, Rebecca DuBois, Stefano Salvioli, and Their Constitutive Expression Restricts Infection Scott S. Blystone, Felix Rey, and Gabriella Campadelli-Fiume Regulation of ICP0-Null Mutant Herpes Simplex Virus Type Vera Lukashchuk and Roger D. 4026–4040 1 Infection by ND10 Components ATRX and hDaxx Everett Antagonism of CD317 Restriction of Human Christine Goffinet, Stefanie 4089–4094 Immunodeficiency Virus Type 1 (HIV-1) Particle Release Homann, Ina Ambiel, Nadine and Depletion of CD317 Are Separable Activities of HIV-1 Tibroni, Daniel Rupp, Oliver T. Vpu Keppler, and Oliver T. Fackler Donor and Recipient Envs from Heterosexual Human Melissa Alexander, Rebecca Lynch, 4100–4104 Immunodeficiency Virus Subtype C Transmission Pairs Joseph Mulenga, Susan Allen, Require High Receptor Levels for Entry Cynthia A. Derdeyn, and Eric Hunter Caulimoviridae Tubule-Guided Transport Is Dictated by Jesu´s Sa´nchez-Navarro, Thor 4109–4112 Movement Protein Properties Fajardo, Stefania Zicca, Vicente Palla´s, and Livia Stavolone
CELLULAR RESPONSE TO INFECTION Type I Interferon-Sensitive Recombinant Newcastle Disease Subbiah Elankumaran, Vrushali 3835–3844 Virus for Oncolytic Virotherapy Chavan, Dan Qiao, Raghunath Shobana, Gopakumar Moorkanat, Moanaro Biswas, and Siba K. Samal Rabies Virus Nucleoprotein Functions To Evade Activation Tatsunori Masatani, Naoto Ito, 4002–4012 of the RIG-I-Mediated Antiviral Response Kenta Shimizu, Yuki Ito, Keisuke Nakagawa, Yoshiharu Sawaki, Hiroyuki Koyama, and Makoto Sugiyama Direct Evidence from Single-Cell Analysis that Human ␣- Emily K. Nguyen, Glen R. 4041–4049 Defensins Block Adenovirus Uncoating To Neutralize Nemerow, and Jason G. Smith Infection Impact of Varicella-Zoster Virus on Dendritic Cell Subsets Jennifer H. Huch, Anthony L. 4060–4072 in Human Skin during Natural Infection Cunningham, Ann M. Arvin, Najla Nasr, Saskia J. A. M. Santegoets, Eric Slobedman, Barry Slobedman, and Allison Abendroth
TRANSFORMATION AND ONCOGENESIS Antisense Transcription in Gammaretroviruses as a Mads Heilskov Rasmussen, Borja 3780–3788 Mechanism of Insertional Activation of Host Genes Ballarín-Gonza´lez, Jinghua Liu, Louise Berkhoudt Lassen, Annette Fu¨chtbauer, Ernst-Martin Fu¨chtbauer, Anders Lade Nielsen, and Finn Skou Pedersen Distinct p53, p53:LANA, and LANA Complexes in Kaposi’s Wuguo Chen, Isaac B. Hilton, 3898–3908 Sarcoma-Associated Herpesvirus Lymphomas Michelle R. Staudt, Christin E. Burd, and Dirk P. Dittmer
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E1A Interacts with Two Opposing Transcriptional Pathways Jingfeng Sha, Mrinal K. Ghosh, 4050–4059 To Induce Quiescent Cells into S Phase Keman Zhang, and Marian L. Harter
VACCINES AND ANTIVIRAL AGENTS A Chimeric Alphavirus Replicon Particle Vaccine Expressing Chien-Hsiung Pan, Catherine E. 3798–3807 the Hemagglutinin and Fusion Proteins Protects Juvenile Greer, Debra Hauer, Harold S. and Infant Rhesus Macaques from Measles Legg, Eun-Young Lee, M. Jeff Bergen, Brandyn Lau, Robert J. Adams, John M. Polo, and Diane E. Griffin Env-Expressing Autologous T Lymphocytes Induce Mauro Pistello, Francesca Bonci, 3845–3856 Neutralizing Antibody and Afford Marked Protection against Elisa Zabogli, Francesca Conti, Feline Immunodeficiency Virus Giulia Freer, Fabrizio Maggi, Mario Stevenson, and Mauro Bendinelli T Cells Engineered with a Cytomegalovirus-Specific Florian Full, Manfred Lehner, 4083–4088 Chimeric Immunoreceptor Veronika Thonn, Gabriel Goetz, Brigitte Scholz, Kerstin B. Kaufmann, Michael Mach, Hinrich Abken, Wolfgang Holter, and Armin Ensser Contribution of Vaccine-Induced Immunity toward either Victor C. Huber, Ville Peltola, Amy 4105–4108 the HA or the NA Component of Influenza Viruses Limits R. Iverson, and Jonathan A. Secondary Bacterial Complications McCullers
PATHOGENESIS AND IMMUNITY Introduction of Virulence Markers in PB2 of Pandemic Sander Herfst, Salin Chutinimitkul, 3752–3758 Swine-Origin Influenza Virus Does Not Result in Enhanced Jianqiang Ye, Emmie de Wit, Virulence or Transmission Vincent J. Munster, Eefje J. A. Schrauwen, Theo M. Bestebroer, Marcel Jonges, Adam Meijer, Marion Koopmans, Guus F. Rimmelzwaan, Albert D. M. E. Osterhaus, Daniel R. Perez, and Ron A. M. Fouchier NKp46 O-Glycan Sequences That Are Involved in the Michal Mendelson, Yoram Tekoah, 3789–3797 Interaction with Hemagglutinin Type 1 of Influenza Virus Alon Zilka, Orly Gershoni- Yahalom, Roi Gazit, Hagit Achdout, Nicolai V. Bovin, Tal Meningher, Michal Mandelboim, Ofer Mandelboim, Ayelet David, and Angel Porgador Proliferation Capacity and Cytotoxic Activity Are Mediated Cristina Cellerai, Matthieu Perreau, 3868–3878 by Functionally and Phenotypically Distinct Virus-Specific Virginie Rozot, Felicitas Bellutti CD8 T Cells Defined by Interleukin-7R␣ (CD127) and Enders, Giuseppe Pantaleo, and Perforin Expression Alexandre Harari A Mouse Model of Lethal Infection for Evaluating Jennifer Stabenow, R. Mark Buller, 3909–3920 Prophylactics and Therapeutics against Monkeypox Virus Jill Schriewer, Cheri West, John E. Sagartz, and Scott Parker Pathogenesis of a Model Gammaherpesvirus in a Natural David J. Hughes, Anja Kipar, 3949–3961 Host Jeffery T. Sample, and James P. Stewart
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Dynamics of Influenza Virus Infection and Pathology Roberto A. Saenz, Michelle 3974–3983 Quinlivan, Debra Elton, Shona MacRae, Anthony S. Blunden, Jennifer A. Mumford, Janet M. Daly, Paul Digard, Ann Cullinane, Bryan T. Grenfell, John W. McCauley, James L. N. Wood, and Julia R. Gog Killing of Avian and Swine Influenza Virus by Natural Hagit Achdout, Tal Meningher, 3993–4001 Killer Cells Shira Hirsh, Ariella Glasner, Yotam Bar-On, Chamutal Gur, Angel Porgador, Michal Mendelson, Michal Mandelboim, and Ofer Mandelboim Interleukin 18 Coexpression during Respiratory Syncytial James A. Harker, Alexandra 4073–4082 Virus Infection Results in Enhanced Disease Mediated by Godlee, Jennifer L. Wahlsten, Natural Killer Cells Debbie C. P. Lee, Lucy G. Thorne, Devika Sawant, John S. Tregoning, Rachel R. Caspi, Alexander Bukreyev, Peter L. Collins, and Peter J. M. Openshaw
ERRATUM Letter to the Editor: Genetic Linkage of Hepatitis B Virus in Sibnarayan Datta, Rajesh Panigrahi, 4113 Peripheral Blood Leukocytes Provides Evidence for Avik Biswas, and Runu Chakravarty Contamination
AUTHOR’S CORRECTION Functional Characterization of the Human Laura L. Baugh, J. Victor Garcia, 4114 Immunodeficiency Virus Type 1 Nef Acidic Domain and John L. Foster
Cover photograph (Copyright © 2010, American Society for Microbiology. All Rights Reserved.): Artistic interpretation (graphic collage) by Hannah Heilmann of the ongoing battle between virulent phage and their bacterial hosts. Virulent phages and their bacterial hosts represent an unusual sort of predator-prey system where each time a prey is eaten, hundreds of new predators are born. Despite the apparent effectiveness of the phage predators, they manage to avoid driving their bacterial prey to extinction. (See related article in March 2010, vol. 84, no. 6, p. 3016.)