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Curriculum Vitae Prof. Dr. Elisa Izaurralde

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Curriculum Vitae Prof. Dr. Elisa Izaurralde Name: Elisa Izaurralde Geboren: 20. September 1959 Verstorben: 30. April 2018 Forschungsschwerpunkte: Genexpression, RNA-Metabolismus, RNA-Exosom, Röntgen- kristallographie, Kern-Zytoplasma-Transport, mRNA-Abbau Elisa Izaurralde ist Molekularbiologin. Schwerpunkte ihrer Forschung sind Mechanismen der Genexpression und Transportwege in den Zellen. Sie hat einen neuen Transportweg für den Abbau von RNA aus dem Zellkern aufgezeigt und detailliert Mechanismen des RNA-Stoffwechsels beschrieben. Akademischer und beruflicher Werdegang 2005 - 2018 Direktorin und Wissenschaftliches Mitglied am Max-Planck-Institut für Entwicklungsbiologie 2004 - 2006 Senior Scientist am EMBL, Heidelberg 1999 - 2004 Gruppenleiterin im Gene Expression Program, EMBL, Heidelberg 1996 - 1999 Forschungsgruppenleiterin am Institut für Molekularbiologie der Universität Genf 1990 - 1996 Postdoktorandin am European Molecular Biology Laboratory (EMBL), Heidelberg 1989 - 1990 Postdoktorandin an der Universität Genf 1989 Promotion an der Universität Genf Studium der Biochemie in Genf Funktionen in wissenschaftlichen Gesellschaften und Gremien 2016 Mitorganisatorin des Cold Spring Harbor meeting on Non-coding RNAs, Cold Spring Harbor, New York, USA Nationale Akademie der Wissenschaften Leopoldina www.leopoldina.org 1 seit 2015 Vorsitzende des LS1 Advanced Grant Panel des European Research Council 2015 Organisatorin des EMBO-/EMBL-Symposiums: „The non-coding genome”, Heidelberg 2015 Evaluationskomitee des Instituts für Biochemie, Eidgenössische Technische Hochschule (ETH) Zürich 2014 Vorsitzende „Molekular- und Strukturbiologie” im Biochemie-Ausschuss des ATIPE- Avenir Programms, Frankreich 2011 - 2013 Ausschuss-Mitglied der ERC-2011-Advanced Grants 2014 Mitorganisatorin des Cold Spring Harbor meeting on Non-coding RNAs, Cold Spring Harbor, USA seit 2014 Editorial Board „PLOS Biology“ 2013 Organisatorin des EMBO-/EMBL-Symposiums: „The non-coding genome”, Heidelberg 2012 Mitorganisatorin des Cold Spring Harbor meeting on Non-coding RNAs, Cold Spring Harbor, USA 2012 Plenary lecture im EMBO Meeting 2012, Nizza, Frankreich seit 2012 Board of reviewing editors „eLife“ 2011 L'Oreal Plenary Lecture im 34th Congress of the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Barcelona, Spanien 2011 Organisatorin des Keystone Symposiums, Mechanism and Biology of Silencing, Monterey, Kalifornien, USA seit 2011 Editor „RNA“ 2010 Organisatorin des EMBO-/EMBL-Symposiums: „The non-coding genome”, Heidelberg seit 2009 Wissenschaftlicher Beirat des Max-Delbrück-Centrums für Molekulare Medizin (MDC), Berlin seit 2007 Advisory Editorial Board des „EMBO Journal“ seit 2007 Advisory Editorial Board der „EMBO Reports“ 2007 - 2011 Editor „FEBS Journal“ 2006 - 2009 Editorial Board „Molecular and Cellular Biology“ 2006 - 2009 Highlights Advisory Panel für „Nature Reviews Molecular Cell Biology“ seit 2005 Gutachterausschuss für unabhängige Max-Planck-Juniorforschungsgruppen 2005 - 2011 Editorial Board „RNA“ 2005 - 2009 Gutachterausschuss des EMBO Young Investigator Program 2004 - 2010 Editorial Board „European Journal of Cell Biology“ Nationale Akademie der Wissenschaften Leopoldina www.leopoldina.org 2 2004 - 2006 Programmkoordinatorin des Gene Expression Program, EMBL, Heidelberg 2003 - 2008 Gutachterausschuss für ATIPE-Stipendien, Frankreich 2001 - 2005 Gutachterkomitee für HFSPO-Langzeit-Stipendien Projektkoordination, Mitgliedschaft in Verbundprojekten 2007 - 2014 DFG-Projekt „Role of GW182 proteins in miRNA-mediated gene silencing”, Teilprojekt zu FOR 855 „Cytoplasmic regulation of gene expression” Auszeichnungen und verliehene Mitgliedschaften seit 2016 Mitglied der Academia Europaea 2012 Ernst-Jung-Preis seit 2009 Mitglied der Nationalen Akademie der Wissenschaften Leopoldina 2008 Gottfried-Wilhelm-Leibniz Preis der DFG (gemeinsam mit Elena Conti) 2004 Mitglied im Board of Directors der RNA Society 2000 Young Scientist Award der European Life Science Organization (ELSO) 2000 Mitglied der European Molecular Biology Organization (EMBO) 1999 Friedrich Miescher-Preis, Schweizerische Gesellschaft für Biochemie Forschungsschwerpunkte Elisa Izaurralde ist Molekularbiologin. Schwerpunkte ihrer Forschung sind Mechanismen der Genexpression und Transportwege in den Zellen. Sie hat einen neuen Transportweg für den Export von RNA aus dem Zellkern aufgezeigt und detailliert Mechanismen des RNA-Stoffwechsels beschrieben. Elisa Izaurralde erforscht, wie Proteine und RNA-Moleküle (Ribonukleinsäure) zusammenwirken und wie dadurch in der Zelle grundlegende Prozesse reguliert werden, wie beispielsweise das Verarbeiten von genetischer Information (Genexpression), die Zellteilung und die Signalweiterleitung. RNA- Moleküle kommen in großer Zahl in der Zelle vor, sie übermitteln genetische Informationen und regulieren Gene. Nicht benötigte oder defekte RNAs müssen in der Zelle entsorgt werden. Elisa Izaurralde hat einen neuen Transportweg für den Export der Boten-RNA aus dem Zellkern identifiziert und den Abbauweg für fehlerhafte Boten-RNA-Moleküle im Detail beschrieben. Ein wesentlicher Teilprozess der Genexpression ist die Entstehung von RNA anhand einer DNA- Vorlage (Transkription). Lange wurde angenommen, dass die Genexpression hauptsächlich auf der Transkriptionsebene reguliert wird. Inzwischen ist bekannt, dass es auch nach der Transkription Nationale Akademie der Wissenschaften Leopoldina www.leopoldina.org 3 Mechanismen gibt, mit denen Zellen Gene regulieren. Eliza Izaurralde untersucht mit ihrem Team solche Post-Transkriptionsprozesse (mRNA-Verarbeitung, Export, Überwachung, Silencing, Umsatz). Die Prozesse sind miteinander verknüpft und bilden ein komplexes Netzwerk, das Gene reguliert und zu spezifischen Genexpressionsmustern beiträgt. Mit ihrer Forschung möchte Elisa Izaurralde weiter aufklären, wie die Netzwerke auf der posttranskriptionalen Ebene miteinander und mit verschiedenen zellulären Prozessen verbunden sind. Ihr Ziel ist es, die Rolle der posttranskriptionellen Prozesse bei der Genexpression aufzuzeigen und zu verstehen, was passiert, wenn diese Prozesse gestört sind. Nationale Akademie der Wissenschaften Leopoldina www.leopoldina.org 4 .
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