DOCSLIB.ORG

Annual Report 20

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Annual Report 20 80045• HFSP-RA-2011-couv_couv2012 04/06/12 16:44 Page1 11 Acknowledgements HFSPO is grateful for the support of: Australia National Health and Medical Research Council (NHMRC) Canada Canadian Institute of Health Research (CIHR) Natural Sciences and Engineering Research Council (NSERC) European Union European Commission - Directorate General Information Society (DG INFSO) 20 REPORT ANNUAL European Commission - Directorate General Research (DG RESEARCH) France Communauté Urbaine de Strasbourg (CUS) Ministère de l’Enseignement Supérieur et de la Recherche (MESR) Région Alsace Germany Federal Ministry of Education and Research (BMBF) India Department of Biotechnology (DBT) Ministry of Science and Technology Italy Ministry of Education, University and Research Japan Ministry for Economy, Trade and Industry (METI) Ministry of Education, Culture, Sports, Science and Technology (MEXT) Republic of Korea Ministry of Education, Science and Technology (MEST) New Zealand Health Research Council (HRC) Norway Research Council of Norway (RCN) Switzerland State Secretariat for Education and Research (SER) United Kingdom Biotechnology and Biological Sciences Research Council (BBSRC) Medical Research Council (MRC) The International Human Frontier Science United States of America Program Organization (HFSPO) National Institutes of Health (NIH) 12 quai Saint Jean - BP 10034 National Science Foundation (NSF) 67080 Strasbourg CEDEX - France Fax. +33 (0)3 88 32 88 97 e-mail: [email protected] Web site: www.hfsp.org Japanese web site: http://jhfsp.jsf.or.jp 80045• HFSP-RA-2011-couv_couv2012 04/06/12 16:44 Page2 HUMAN FRONTIER SCIENCE PROGRAM The Human Frontier Science Program is unique, supporting international collaboration to undertake innovative, risky, basic research at the frontier of the life sciences. Special emphasis is given to the support and training of independent young investigators, beginning at the postdoctoral level. The Program is implemented by an international organisation, supported financially by Australia, Canada, France, Germany, India, Italy, Japan, the Republic of Korea, New Zealand, Norway, Switzerland, the United Kingdom, the United States of America, and the European Union. Since 1990, over 6000 awards have been made to researchers from more than 70 countries. Of these, HFSPO 18 HFSP awardees have gone on to receive the Nobel Prize. Registre des Associations de Strasbourg Volume 58- Folio 99 Achevé d’imprimé en juillet deux mille douze sur les presses de Faber The International Human Frontier Science Program Organization (HFSPO) 12 quai Saint Jean BP 10034 67080 Strasbourg CEDEX France Fax. +33 (0)3 88 32 88 97 e-mail: [email protected] Web site: www.hfsp.org Japanese web site: http://jhfsp.jsf.or.jp © Photos: HFSPO thanks Rae Silver (p.14), Jyotsna Dhawan (p.37) and Gina Turrigiano (p.40) for supplementary photos in addition to those provided by Sandro Weltin (p.7,9,10,15,17,27,39), Musashi University (p.12), Owen Egan (p.41), Martin Reddington (p.44) and those taken from the website of the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden (p.22), Duke University (p.25), shutterstock/ David Lee (p.1), shutterstock/ Vaclav Volrab (p.2), shutterstock/ irin-k (p.3), shutterstock/ vblinov (p.6), shutterstock/ FotoVeto (p.7), shutterstock/ pandapaw (p.16), shutterstock/ Kesu (p.26), shutterstock/ Cuiphoto (p.38), shutterstock/ panda3800 (p.52), shutterstock/ Eric Isselée (p.64), shutterstock/ Wallenrock (p.74). 80045• HFSP-RA-2011-chap1_HFSP-RA-2011-chap1 24/05/12 16:34 Page3 APRIL 2011 - MARCH 2012 ANNUAL REPORT — 3 — 80045• HFSP-RA-2011-chap1_HFSP-RA-2011-chap1 24/05/12 16:34 Page4 Table of contents The following documents are available on the HFSP web site www.hfsp.org Joint Communiqués (Tokyo 1992, Washington 1997, Berlin 2002, Bern 2004, Ottawa 2007, Canberra 2010): http://www.hfsp.org/about-us/governance/intergovernmental-conference Statutes of the International Human Frontier Science Program Organization: http://www.hfsp.org/about-us/governance/statutes Guidelines for the participation of new members in the HFSP: http://www.hfsp.org/about-us/new-membership General Reviews of the HFSP (1996, 2001, 2006-2007, 2010): http://www.hfsp.org/about-us/reviews-hfsp Updated and previous lists of awards, including titles and abstracts: http://www.hfsp.org/awardees — 4 — 80045• HFSP-RA-2011-chap1_HFSP-RA-2011-chap1 24/05/12 16:34 Page5 INTRODUCTION 7 Introduction 8 Highlights in FY 2011 9 Message of the Secretary General 10 Board of Trustees 12 Council of Scientists 14 Secretariat 15 CHAPTER 1 - FELLOWSHIP PROGRAM 17 1.1 Introduction 18 1.2 Long-Term and Cross-Disciplinary Fellowships 18 1.3 Fellowship Awards in 2012 20 1.4 The 2012 Review Committee for Fellowships 22 1.5 Career Development Awards 23 1.6 Career Development Awards in 2012 24 1.7 The 2012 Review Committee for Career Development Awards 25 CHAPTER 2 - RESEARCH GRANT PROGRAM 27 2.1 Overview of the Grant Program 28 2.2 Young Investigator Grants 30 2.3 Program Grants 30 2.4 Research Grant Awards in 2012 31 2.5 The 2012 Review Committee for Research Grants 36 CHAPTER 3 - OUTREACH AND NETWORKING 39 3.1 HFSP Nakasone Award 40 3.2 Awardees Meeting 41 3.3 Communications 42 3.4 Honours and prizes 45 CHAPTER 4 - BUDGET AND FINANCE 59 4.1 Guidelines for HFSPO funding 54 4.2 Key financial figures for FY 2011 54 4.3 FY 2011 financial summary 61 4.4 Budget for program activities FY 2012 63 APPENDIX 77 A.1 History of the Program 70 A.2 Joint Communiqué of the Intergovernmental Conference on the Human Frontier Science Program, Canberra, 28 May 2010 72 A.3 Summary of decisions of the Board of Trustees in 2011 74 A.4 Long-Term and Cross-Disciplinary Fellowships awarded in 2011 75 A.5 Career Development Awards made in 2011 78 A.6 Research Grants awarded in 2011 79 — 5 — 80045•HFSP-RA-2011-chap1_HFSP-RA-2011-chap1 24/05/12 16:34 Page6 — 6 — 80045• HFSP-RA-2011-chap1_HFSP-RA-2011-chap1 24/05/12 16:34 Page7 Introduction Introduction Highlights in FY 2011 Message of the Secretary General Board of Trustees Council of Scientists Secretariat Ernst-Ludwig Winnacker (Secretary General), Toru Nakahara (Deputy Secretary General) and Jill Husser — 7 — 80045• HFSP-RA-2011-chap1_HFSP-RA-2011-chap1 24/05/12 16:34 Page8 Introduction Since 1990, 898 Research Grants involving 3,388 scientists, 2,600 Long-Term, 73 Cross-Disciplinary Fellowships and 173 Career Development Awards have been awarded. Researchers from more than 70 countries have received HFSP funding so far. The focus of research supported by HFSP is on the complex mechanisms of living organisms, ranging from the biomolecular level to that of behaving organisms. The life sciences have undergone a revolution in recent years, emerging as a leading The Human Frontier Science Program (HFSP) scientific area with a convergence of interest from promotes fundamental research in the life other disciplines such as physics, mathematics, sciences with special emphasis on novel and chemistry, computer science and engineering on interdisciplinary research, international and in solving biological questions. HFSP aims to stay at the particular intercontinental collaboration and forefront of research by involving scientists from support for young investigators. Since its outside the life sciences as part of research establishment in 1989, HFSP has demonstrated collaborations and as postdoctoral fellows. To this end, the value of creating a framework for the Young Investigator and Program Grants are competitive, collaborative, international research specifically geared to fostering interactions between scientists from different disciplines and this is a major of the highest caliber and of providing young factor in the review of applications in these programs. scientists with the opportunity to emerge as In addition, HFSP has extended its commitment to talented researchers capable of shaping the interdisciplinary research by introducing science of the future. Cross-Disciplinary Fellowships to equip young scientists from outside biology with the skills needed The International Human Frontier Science Program to tackle problems in the life sciences. Organization (HFSPO) implements the Program through the following mechanisms of research A program dedicated to the frontiers of science must support, details of which can be found in Chapters 1 support the next generation of researchers, who are in and 2 of this report: the strongest position to open new avenues of research. Several of the HFSP programs are specifically ■ Long-Term Fellowships – for young scientists within targeted towards early career scientists: the Fellowship three years of obtaining their Ph.D who wish to programs, Career Development Award and Young broaden their scientific experience in a foreign Investigator Grant. In addition, Program Grant teams laboratory. are encouraged to include young scientists with the result that a significant number of scientists under ■ Cross-Disciplinary Fellowships – modeled on the the age of 40 participate in this program. Taking these Long-Term Fellowships but specifically for scientists researchers together, approximately 70% of annual with Ph.Ds in non-biological disciplines who seek HFSP funds are awarded to early career researchers. training in the life sciences. ■ Career Development Awards – for former HFSP The HFSPO is financed and managed by Fellows to help them set up their own independent representatives of the Management Supporting laboratories in the home country or another HFSP Parties (MSPs). The MSPs are those countries that member country. directly fund the HFSP Programs plus the European Union, which represents the EU countries that do ■ Young Investigator Grants – grants for interdisciplinary not contribute directly. The MSPs are: Australia, teams of young researchers who are within the first Canada, France, Germany, India, Italy, Japan, the five years of their first independent positions and Republic of Korea, New Zealand, Norway, located in different countries. Switzerland, the United Kingdom, the United States of America and the European Union. ■ Program Grants – for interdisciplinary teams of Japan provided about 45 % of MSPs’ contributions researchers in different countries at any stage of for FY 2011.
Load more

Recommended publications
  • Solid-State Synthesis and Mechanical Unfolding of Polymers of T4 Lysozyme
    Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme Guoliang Yang*, Ciro Cecconi*, Walter A. Baase†, Ingrid R. Vetter‡, Wendy A. Breyer†, Julie A. Haack§, Brian W. Matthews†¶, Frederick W. Dahlquist†i, and Carlos Bustamante*,**,††,‡‡ Departments of *Molecular and Cell Biology and **Physics, University of California, Berkeley, CA 94720; ††Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720; †Institute of Molecular Biology, ¶Howard Hughes Medical Institute, and iDepartment of Chemistry, University of Oregon, Eugene, OR 97403; ‡Max-Planck-Institute for Molecular Physiology, Department of Structural Biology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany; and §Nutri-Logics, Inc., 111 SW Columbia Street, Suite 755, Portland, OR 97201 Contributed by Brian W. Matthews, October 26, 1999 Recent advances in single molecule manipulation methods offer a polymers of bacteriophage T4 lysozyme in the solid state. T4 novel approach to investigating the protein folding problem. These lysozyme was chosen to demonstrate the method because its studies usually are done on molecules that are naturally organized structure is known, and its folding-unfolding behavior both for as linear arrays of globular domains. To extend these techniques to the wild type and a large number of mutants has been extensively study proteins that normally exist as monomers, we have devel- investigated by bulk solution methods. After identifying posi- oped a method of synthesizing polymers of protein molecules in tions at which adjacent molecules contact each other in the the solid state. By introducing cysteines at locations where bacte- crystal lattice, a site-directed mutant was generated in which the riophage T4 lysozyme molecules contact each other in a crystal and corresponding residues were replaced by cysteines while all other taking advantage of the alignment provided by the lattice, we cysteines were substituted by structurally neutral residues, such have obtained polymers of defined polarity up to 25 molecules as alanine.
    [Show full text]
  • CURRICULUM VITAE Laura Finzi
    CURRICULUM VITAE Laura Finzi Physics Department, Emory University e-mail: [email protected] 400 Dowman Dr, Atlanta, GA 30322 http://www.physics.emory.edu/faculty/finzi/ tel. 404-727-4930 ; fax: 404-727-0873 EDUCATION_________________________________________________________________________________ 1990 Ph.D. in Chemistry, University of New Mexico, Albuquerque, NM. (Advisor: Carlos Bustamante) 1987 Master's in Chemistry, University of New Mexico, Albuquerque, NM. 1984 Laurea in Industrial Chemistry, University of Bologna, Bologna, Italy. 1979 Diploma from Liceo Classico "M. Minghetti" (High School diploma), Bologna, Italy. PROFESSIONAL ACTIVITY____________________________________________________________________ September 2012 - present: Full Professor, Physics Department, Emory University. July 2005-August 2012: Associate Professor, Physics Department, Emory University. June 1999-June 2005: Tenured Researcher and Group Leader, Biology Dept, University of Milano, Italy. 1993-May 1999: Researcher (tenured in ’96), Biology Dept, University of Milan, Italy. 1992-1993: Post Doctoral Fellow, Biochemistry Dept., Brandeis University (Mentor: Jeff Gelles). 1990-1991: Post Doctoral Fellow, Chem. Dept., University of New Mexico (October-December 1990), Institute of Molecular Biology, University of Oregon (January-December 1991) (Carlos Bustamante group). HONORS and AWARDS________________________________________________________________________ 2018: Recognized for “Excellent Teaching” by Phi Beta Kappa Mentee. Ceremony held on 4/10 in Cannon Chapel.
    [Show full text]
  • EMBC Annual Report 2007
    EMBO | EMBC annual report 2007 EUROPEAN MOLECULAR BIOLOGY ORGANIZATION | EUROPEAN MOLECULAR BIOLOGY CONFERENCE EMBO | EMBC table of contents introduction preface by Hermann Bujard, EMBO 4 preface by Tim Hunt and Christiane Nüsslein-Volhard, EMBO Council 6 preface by Marja Makarow and Isabella Beretta, EMBC 7 past & present timeline 10 brief history 11 EMBO | EMBC | EMBL aims 12 EMBO actions 2007 15 EMBC actions 2007 17 EMBO & EMBC programmes and activities fellowship programme 20 courses & workshops programme 21 young investigator programme 22 installation grants 23 science & society programme 24 electronic information programme 25 EMBO activities The EMBO Journal 28 EMBO reports 29 Molecular Systems Biology 30 journal subject categories 31 national science reviews 32 women in science 33 gold medal 34 award for communication in the life sciences 35 plenary lectures 36 communications 37 European Life Sciences Forum (ELSF) 38 ➔ 2 table of contents appendix EMBC delegates and advisers 42 EMBC scale of contributions 49 EMBO council members 2007 50 EMBO committee members & auditors 2007 51 EMBO council members 2008 52 EMBO committee members & auditors 2008 53 EMBO members elected in 2007 54 advisory editorial boards & senior editors 2007 64 long-term fellowship awards 2007 66 long-term fellowships: statistics 82 long-term fellowships 2007: geographical distribution 84 short-term fellowship awards 2007 86 short-term fellowships: statistics 104 short-term fellowships 2007: geographical distribution 106 young investigators 2007 108 installation
    [Show full text]
  • 3718 Issue63july2010 1.Pdf
    Issue 63.qxd:Genetic Society News 1/10/10 14:41 Page 1 JULYJULLYY 2010 | ISSUEISSUE 63 GENETICSGENNETICSS SOCIETYSOCIEETY NENEWSEWS In this issue The Genetics Society NewsNewws is edited by U Genetics Society PresidentPresident Honoured Honoured ProfProf David Hosken and items ittems for future future issues can be sent to thee editor,editor, preferably preferably U Mouse Genetics Meeting by email to [email protected],D.J.Hosken@@exeter.ac.uk, or U SponsoredSponsored Meetings Meetings hardhard copy to Chair in Evolutionary Evoolutionary Biology, Biology, UniversityUniversity of Exeter,Exeter, Cornwall Cornnwall Campus, U The JBS Haldane LectureLecture Tremough,Tremough, Penryn, TR10 0 9EZ UK.UK. The U Schools Evolutionn ConferenceConference Newsletter is published twicet a year,year, with copy dates of 1st June andand 26th November.November. U TaxiTaxi Drivers The British YeastYeaste Group Group descend on Oxford Oxford for their 2010 meeting: m see the reportreport on page 35. 3 Image © Georgina McLoughlin Issue 63.qxd:Genetic Society News 1/10/10 14:41 Page 2 A WORD FROM THE EDITOR A word from the editor Welcome to issue 63. In this issue we announce a UK is recognised with the award of a CBE in the new Genetics Society Prize to Queen’s Birthday Honours, tells us about one of Welcome to my last issue as join the medals and lectures we her favourite papers by Susan Lindquist, the 2010 editor of the Genetics Society award. The JBS Haldane Mendel Lecturer. Somewhat unusually we have a News, after 3 years in the hot Lecture will be awarded couple of Taxi Drivers in this issue – Brian and seat and a total of 8 years on annually to recognise Deborah Charlesworth are not so happy about the committee it is time to excellence in communicating the way that the print media deals with some move on before I really outstay aspects of genetics research to scientific issues and Chris Ponting bemoans the my welcome! It has been a the public.
    [Show full text]
  • Fellows Opted out of the Mentoring Programme As of 19 March 2020 1
    Fellows opted out of the Mentoring programme as of 19 March 2020 Professor Chris Abell FRS FMedSci Professor Kamlesh Khunti FMedSci Professor Thomas Kirkwood CBE Professor David Adams FMedSci FMedSci Professor Judith Allen FRSE FMedSci Professor Robb Krumlauf FMedSci Professor Charalambos Kyriacou Professor Desmond Archer OBE FMedSci FMedSci Professor Louise Arseneault FMedSci Sir Peter Lachmann FRS FMedSci Professor Michael Arthur FMedSci Professor Leon Lagnado FMedSci Professor Deborah Ashby OBE FMedSci Professor Ajit Lalvani FMedSci Professor Dame Frances Ashcroft DBE Professor Deborah Lawlor CBE FMedSci FRS FMedSci Professor Anthony Barrett FRS FMedSci Professor Joy Lawn FMedSci Professor Facundo Batista FMedSci Professor Susan Lea FMedSci Professor Stephan Beck FMedSci Professor Sir Robert Lechler PMedSci Professor Jill Belch OBE FMedSci Dr Melanie Lee CBE FMedSci Professor Sir John Bell GBE FRS Professor Andrew Lees FMedSci HonFREng FMedSci Professor Wendy Bickmore FRS FRSE Professor Stafford Lightman FRS FMedSci FMedSci Professor Sir Adrian Bird CBE FRS FRSE Professor Janet Lord FMedSci FMedSci Professor Ewan Birney CBE FRS Professor Thomas MacDonald FMedSci FMedSci Professor Dorothy Bishop FRS FBA Professor Rona MacKie CBE FRSE FMedSci FMedSci Sir Stephen Bloom FRS FMedSci Professor Giovanna Mallucci FMedSci Sir Tom Blundell FRS FMedSci Dr Fiona Marshall FMedSci Professor Dame Theresa Marteau DBE Professor Peter Boyle FRSE FMedSci FMedSci Professor Sir Michael Brady FRS FREng Professor Duncan Maskell FMedSci FMedSci Professor
    [Show full text]
  • Annual Report Fy 2018 Human Frontier Science Program Organization
    APRIL 2017 APRIL 2018 — MARCH 2019 ANNUAL REPORT FY 2018 HUMAN FRONTIER SCIENCE PROGRAM ORGANIZATION The Human Frontier Science Program Organization (HFSPO) is unique, supporting international collaboration to undertake innovative, risky, basic research at the frontier of the life sciences. Special emphasis is given to the support and training of independent young investigators, beginning at the postdoctoral level. The Program is implemented by an international organisation, supported financially by Australia, Canada, France, Germany, India, Italy, Japan, the Republic of Korea, New Zealand, Norway, Singapore, Switzerland, the United Kingdom of Great Britain and Nothern Ireland, the United States of America, and the European Commission. Since 1990, over 7000 researchers from more than 70 countries have been supported. Of these, 28 HFSP awardees have gone on to receive the Nobel Prize. 2 The following documents are available on the HFSP website www.hfsp.org: Joint Communiqués (Tokyo 1992, Washington 1997, Berlin 2002, Bern 2004, Ottawa 2007, Canberra 2010, Brussels 2013, London 2016): https://www.hfsp.org/about/governance/membership Statutes of the International Human Frontier Science Program Organization: https://www.hfsp.org/about/governance/hfspo-statutes Guidelines for the participation of new members in HFSPO: https://www.hfsp.org/about/governance/membership General reviews of the HFSP (1996, 2001, 2006-2007, 2010, 2018): https://www.hfsp.org/about/strategy/reviews Updated and previous lists of awards, including titles and abstracts:
    [Show full text]
  • The Trypanosoma Brucei Subpellicular Microtubule Array Is Organized Into Functionally Discrete
    bioRxiv preprint doi: https://doi.org/10.1101/2020.11.09.375725; this version posted November 9, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 The Trypanosoma brucei subpellicular microtubule array is organized into functionally discrete 2 subdomains defined by microtubule associated proteins 3 4 Amy N. Sinclair1,#, Christine T. Huynh1, Thomas E. Sladewski1, Jenna L. Zuromski2, Amanda E. 5 Ruiz2, and Christopher L. de Graffenried1,†,* 6 7 1. Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, 8 02912 9 2. Department of Pathology and Laboratory Medicine, Center for International Health Research, 10 Brown University, Providence, RI 02903 11 *To whom correspondence should be addressed. Phone: +1 (401) 863-6148 E-mail: 12 [email protected]. 13 #. ORCID: 0000-0001-6688-6754 14 †. ORCID: 0000-0003-3386-6487 15 16 Short title: Subpellicular array subdomains in T. brucei 17 18 Abbreviations: Flagellum attachment zone (FAZ), microtubule associated protein (MAP), 19 nucleus (N), kinetoplast (K), immunogold electron microscopy (iEM), transmission electron 20 microscopy (TEM), RNA interference (RNAi), mNeonGreen (mNG), maltose binding protein 21 (MBP), total internal reflection fluorescence microscopy (TIRF) 22 23 Keywords: cytoskeleton, microtubules, microtubule associated proteins, subpellicular 24 microtubule array, trypanosomatid, cell morphology bioRxiv preprint doi: https://doi.org/10.1101/2020.11.09.375725; this version posted November 9, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.
    [Show full text]
  • Lettre Des Neurosciences / Lettreprintemps-ÉTÉ 2013 Numéro 44
    la LA LETTRE DES NEUROSCIENCES / LettrePRINTEMPS-ÉTÉ 2013 NUMÉRO 44 Éditorial 3 Histoire des Neurosciences 4 Histoire récente des récepteurs aux neurotransmetteurs Dossier 8 Le sommeil dans tous ses états Nouveautés en neurosciences 24 La révolution de l’imagerie nanoscopique pour la neurobiologie cellulaire Tribune libre 28 Les neurosciences et le Droit Vie de la Société 31 Des métiers et des emplois pour les docteurs Comptes rendus colloques Changement de décor pour le secrétariat de la Société ! NUMÉRO 44 ISSN 2117-5535 La Lettre des Neurosciences est éditée par la Société des Neurosciences UUniversiténiversité BordeauxSegalen Bordeaux Segalen ·2 case · case 67 67 146, rue Léo-Léo-SaignatSaignat 33076 Bordeaux CCedexedex · France TTél.él. :: +(0)5+(0)557573740 57 57 37 40 | |Fax Fax : :+(0)5 +(0)5 57 57 57 57 3736 6950 [email protected] www.neurosciences.asso.fr Directeur de la publication-Rédacteur en Chef : YvesTillet | INRA - PRC - CNRS UMR 7 247 Univ. de Tours | IFCE Centre de Recherche de Tours 37380 Nouzilly | Fax : 02 47 42 77 43 [email protected] Fabrication : I. Conjat, J.-M. Israel, J.-F. Renaudon Concept maquette : Mazarine communication Comité de rédaction : J.-G. Barbara (Paris), D. Blum (Lille), C. Cleren (Rouen), A. Didier (Lyon), F. Eustache (Caen), S. Gaillard (Strasbourg), M. Garret (Bordeaux), J.-L. Gonzalez De Aguilar (Strasbourg), S. Pinto (Aix-en-Provence), A. Réaux-Le Goazigo (Paris). Ont participé à ce numéro : E. Audinat, B. Buisson, H. Chneiweiss, D. Choquet, J. Falcon, R. Garcia, I. Ghorayeb, C. Gronfier, A. Jean, M. Jouvet, P.-H. Luppi, A.
    [Show full text]
  • Dissertation
    Regulation of gene silencing: From microRNA biogenesis to post-translational modifications of TNRC6 complexes DISSERTATION zur Erlangung des DOKTORGRADES DER NATURWISSENSCHAFTEN (Dr. rer. nat.) der Fakultät Biologie und Vorklinische Medizin der Universität Regensburg vorgelegt von Johannes Danner aus Eggenfelden im Jahr 2017 Das Promotionsgesuch wurde eingereicht am: 12.09.2017 Die Arbeit wurde angeleitet von: Prof. Dr. Gunter Meister Johannes Danner Summary ‘From microRNA biogenesis to post-translational modifications of TNRC6 complexes’ summarizes the two main projects, beginning with the influence of specific RNA binding proteins on miRNA biogenesis processes. The fate of the mature miRNA is determined by the incorporation into Argonaute proteins followed by a complex formation with TNRC6 proteins as core molecules of gene silencing complexes. miRNAs are transcribed as stem-loop structured primary transcripts (pri-miRNA) by Pol II. The further nuclear processing is carried out by the microprocessor complex containing the RNase III enzyme Drosha, which cleaves the pri-miRNA to precursor-miRNA (pre-miRNA). After Exportin-5 mediated transport of the pre-miRNA to the cytoplasm, the RNase III enzyme Dicer cleaves off the terminal loop resulting in a 21-24 nt long double-stranded RNA. One of the strands is incorporated in the RNA-induced silencing complex (RISC), where it directly interacts with a member of the Argonaute protein family. The miRNA guides the mature RISC complex to partially complementary target sites on mRNAs leading to gene silencing. During this process TNRC6 proteins interact with Argonaute and recruit additional factors to mediate translational repression and target mRNA destabilization through deadenylation and decapping leading to mRNA decay.
    [Show full text]
  • Correlating STED and Synchrotron XRF Nano-Imaging Unveils
    TOOLS AND RESOURCES Correlating STED and synchrotron XRF nano-imaging unveils cosegregation of metals and cytoskeleton proteins in dendrites Florelle Domart1,2,3, Peter Cloetens4, Ste´ phane Roudeau1,2, Asuncion Carmona1,2, Emeline Verdier3, Daniel Choquet3,5†, Richard Ortega1,2†* 1Chemical Imaging and Speciation, CENBG, Univ. Bordeaux, Gradignan, France; 2CNRS, IN2P3, CENBG, UMR 5797, Gradignan, France; 3Univ. Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France; 4ESRF, the European Synchrotron, Grenoble, France; 5Univ. Bordeaux, CNRS, INSERM, Bordeaux Imaging Center, BIC, UMS, Bordeaux, France Abstract Zinc and copper are involved in neuronal differentiation and synaptic plasticity but the molecular mechanisms behind these processes are still elusive due in part to the difficulty of imaging trace metals together with proteins at the synaptic level. We correlate stimulated- emission-depletion microscopy of proteins and synchrotron X-ray fluorescence imaging of trace metals, both performed with 40 nm spatial resolution, on primary rat hippocampal neurons. We reveal the co-localization at the nanoscale of zinc and tubulin in dendrites with a molecular ratio of about one zinc atom per tubulin-ab dimer. We observe the co-segregation of copper and F-actin within the nano-architecture of dendritic protrusions. In addition, zinc chelation causes a decrease in the expression of cytoskeleton proteins in dendrites and spines. Overall, these results indicate *For correspondence: new functions for zinc and copper in the modulation of the cytoskeleton morphology in dendrites, a [email protected] mechanism associated to neuronal plasticity and memory formation. †These authors contributed equally to this work Competing interests: The Introduction authors declare that no The neurobiology of copper and zinc is a matter of intense investigation since they have been competing interests exist.
    [Show full text]
  • 2011 Gairdner Foundation Annual Report
    2011 GAIRDNER FOUNDATION ANNUAL REPORT May 30, 2012 TABLE OF CONTENTS TABLE OF CONTENTS ...................................................................................................................................... 2 HISTORY OF THE GAIRDNER FOUNDATION .............................................................................................. 3 MISSION,VISION ................................................................................................................................................ 4 GOALS .................................................................................................................................................................. 5 MESSAGE FROM THE CHAIR .......................................................................................................................... 6 MESSAGE FROM THE PRESIDENT/SCIENTIFIC DIRECTOR ..................................................................... 7 2011 YEAR IN REVIEW ..................................................................................................................................... 8 REPORT ON 2011 OBJECTIVES ..................................................................................................................... 12 THE YEAR AHEAD: OBJECTIVES FOR 2012 ............................................................................................... 13 2011 SPONSORS ................................................................................................................................................ 14 GOVERNANCE
    [Show full text]
  • 2014-2015 Annual Report
    THE HELEN HAY WHITNEY FOUNDATION 2014-2015 Annual REport 20 Squadron Boulevard, Suite 630 New City, NY 10956 www.hhwf.org Tel: (845) 639-6799 Fax: (845) 639-6798 THE HELEN HAY WHITNEY FOUNDATION BOARD OF TRUSTEES Averil Payson Meyer, President Steven C. Harrison, Ph.D., Vice President Lisa A. Steiner, M.D., Vice President W. Perry Welch, Treasurer Thomas M. Jessell, Ph.D. Payne W. Middleton Thomas P. Sakmar, M.D. Stephen C. Sherrill SCIENTIFIC ADVISORY COMMITTEE Steven C. Harrison, Ph.D., Chairman David J. Anderson, Ph.D. Daniel Kahne, Ph.D. Philippa Marrack, Ph.D. Markus Meister, Ph.D. Barbara J. Meyer, Ph.D. Julie A. Theriot, Ph.D. Jonathan S. Weissman, Ph.D. S. Lawrence Zipursky, Ph.D. ADMINISTRATIVE DIRECTOR and SECRETARY Robert Weinberger Page 1 REPORT OF THE VICE PRESIDENT AND CHAIRMAN, SCIENTIFIC ADVISORY COMMITTEE I am pleased to report on two years of activity for the Scientific Advisory Committee. Our charge, to select an outstanding group of Fellows each year and to respond as needed to advisory issues that occasionally arise during the tenure of their fellowship, is always a stimulating one, and the talks from third-year Fellows at the Annual Meeting continue to give remarkably positive feedback. Our partnerships with HHMI, the Simons Foundation, and Merck have benefitted the program greatly. We have three Simons Fellows, eight HHMI Fellows and two Merck Fellows, in addition to the eleven we now support from endowment income. (Let me add, on behalf of the SAC, a note of thanks to Perry Welch, the Treasurer of the Foundation, who oversees that endowment with great dedication and insight.) A class of 24 means the competition is fierce, and we continue to identify an extraordinary group of young biomedical scientists.
    [Show full text]