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Etude Des Techniques De Super-Résolution Latérale En Nanoscopie Et Développement D’Un Système Interférométrique Nano-3D Audrey Leong-Hoï
Etude des techniques de super-résolution latérale en nanoscopie et développement d’un système interférométrique nano-3D Audrey Leong-Hoï To cite this version: Audrey Leong-Hoï. Etude des techniques de super-résolution latérale en nanoscopie et développement d’un système interférométrique nano-3D. Micro et nanotechnologies/Microélectronique. Université de Strasbourg, 2016. Français. NNT : 2016STRAD048. tel-02003485 HAL Id: tel-02003485 https://tel.archives-ouvertes.fr/tel-02003485 Submitted on 1 Feb 2019 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. UNIVERSITÉ DE STRASBOURG ÉCOLE DOCTORALE MATHEMATIQUES, SCIENCES DE L'INFORMATION ET DE L'INGENIEUR (MSII) – ED 269 LABORATOIRE DES SCIENCES DE L'INGENIEUR, DE L'INFORMATIQUE ET DE L'IMAGERIE (ICUBE UMR 7357) THÈSE présentée par : Audrey LEONG-HOI soutenue le : 2 DÉCEMBRE 2016 pour obtenir le grade de : Docteur de l’université de Strasbourg Discipline / Spécialité : Electronique, microélectronique, photonique Étude des techniques de super-résolution latérale en nanoscopie et développement d'un système interférométrique nano-3D THÈSE dirigée par : Dr. MONTGOMERY Paul Directeur de recherche, CNRS, ICube (Strasbourg) Pr. SERIO Bruno Professeur des Universités, Université Paris Ouest, LEME (Paris) RAPPORTEURS : Dr. GORECKI Christophe Directeur de recherche, CNRS, FEMTO-ST (Besançon) Pr. -
Multiplexed Biomimetic Lipid Membranes on Graphene by Dip-Pen Nanolithography
ARTICLE Received 17 May 2013 | Accepted 10 Sep 2013 | Published 10 Oct 2013 DOI: 10.1038/ncomms3591 OPEN Multiplexed biomimetic lipid membranes on graphene by dip-pen nanolithography Michael Hirtz1,*, Antonios Oikonomou2,*, Thanasis Georgiou3, Harald Fuchs1,4 & Aravind Vijayaraghavan5 The application of graphene in sensor devices depends on the ability to appropriately func- tionalize the pristine graphene. Here we show the direct writing of tailored phospholipid membranes on graphene using dip-pen nanolithography. Phospholipids exhibit higher mobility on graphene compared with the commonly used silicon dioxide substrate, leading to well-spread uniform membranes. Dip-pen nanolithography allows for multiplexed assembly of phospholipid membranes of different functionalities in close proximity to each other. The membranes are stable in aqueous environments and we observe electronic doping of graphene by charged phospholipids. On the basis of these results, we propose phospholipid membranes as a route for non-covalent immobilization of various functional groups on graphene for applications in biosensing and biocatalysis. As a proof of principle, we demonstrate the specific binding of streptavidin to biotin-functionalized membranes. The combination of atomic force microscopy and binding experiments yields a consistent model for the layer organization within phospholipid stacks on graphene. 1 Institute of Nanotechnology (INT) and Karlsruhe Nano Micro Facility (KNMF), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany. 2 School of Computer Science and Centre for Mesoscience and Nanotechnology, The University of Manchester, Manchester M13 9PL, UK. 3 School of Physics and Astronomy, The University of Manchester, Manchester M13 9PL, UK. 4 Physical Institute and Center for Nanotechnology (CeNTech), University of Mu¨nster, Wilhelm-Klemm-Str. -
(12) United States Patent (10) Patent No.: US 8,088,615 B2 Ausserre (45) Date of Patent: Jan
USOO8088615B2 (12) United States Patent (10) Patent No.: US 8,088,615 B2 Ausserre (45) Date of Patent: Jan. 3, 2012 (54) OPTICAL COMPONENT FOR OBSERVINGA (56) References Cited NANOMETRIC SAMPLE, SYSTEM COMPRISING SAME, ANALYSIS METHOD U.S. PATENT DOCUMENTS USING SAME, AND USES THEREOF 5,639,671 A * 6/1997 Bogartet al. ................. 436,518 (76) Inventor: Dominique Ausserre, Soulitre (FR) 5,962,114 A * 10/1999 Jonza et al. ........ ... 428.212 6,034,775 A * 3/2000 McFarland et al. ............. 506/12 (*) Notice: Subject to any disclaimer, the term of this 6,312,691 B1 * 1 1/2001 Browning et al. ......... 424,143.1 patent is extended or adjusted under 35 6,493.423 B1* 12/2002 Bisschops .............. ... 378,119 U.S.C. 154(b) by 777 days. 6,697,194 B2 * 2/2004 Kuschnereitet al. ... 359,359 6,710,875 B1* 3/2004 Zavislan ............ ... 356,364 (21) Appl. No.: 11/631,846 6,718,053 B1 * 4/2004 Ellis et al. ... ... 38.2/128 Jul. 6, 2005 6,853,455 B1* 2/2005 Dixon et al. ... 356/453 (22) PCT Filed: 6,934,068 B2 * 8/2005 Kochergin ... ... 359,280 (Under 37 CFR 1.47) 7.209,232 B2 * 4/2007 Ausserre et al. 356,369 7,258,838 B2* 8/2007 Lietal. .......... ... 422.68.1 (86). PCT No.: PCT/FR2OOS/OO1746 7,265,845 B2 * 9/2007 Kochergin . ... 356,445 S371 (c)(1), * cited by examiner (2), (4) Date: Aug. 12, 2008 Primary Examiner — Sang Nguyen (87) PCT Pub. No.: WO2006/013287 (74) Attorney, Agent, or Firm — Blank Rome LLP PCT Pub. -
Impact of Nanotechnology on New Instrumentation
Impact of Nanotechnology on New Instrumentation Barbara Foster The Microscopy & Imaging Place, Inc Microscopy/Microscopy Education (MME) www.MicroscopyEducation.com [email protected] • Foster, B., "Focus on Microscopy: Pittcon Gives New Eyes to Chemistry," Am Lab, April 2008 • Foster, B., "Focus on Microscopy: Faster, Smaller, More Economical Imaging Tools at SPIE 2007, The Effect of Nanotechnology,“ Am Lab News, Nov/Dec 2007 • Caveats: No commercial interest Apologies to anyone we missed (PDFs of articles and this paper available in The Library at www.MicroscopyEducation.com) 2 Three key topics • Desktop SEMs – a new product category • Collision between spectroscopy & imaging • Extension of light microscopy into the nano world 3 General trends • Smaller footprints • Simpler design • Easier to use Lab-to-Fab/research to routine transition Ideal for students Routine work: QA/QC, quick check in manufacturing • Expanded analytical capabilities •Muchmore economical 4 Desktop SEMs 1. Evex MiniSEM 2. FEI Phenom 3. Hitachi T1000* 4. Jeol/Nikon NeoScope 5. NovelX MySEM 5 Desktop SEMs– a new product category • Fills the magnification gap between LM and SEM LM – up to about 1000x useful magnification EM – 20,000X and higher • Adds 3-dimensionality L: Light microscopy, Diatome R: SEM, Diatome (14,000x) Images courtesy: FEI 6 Desktop SEMs • Magnifications from 20x to 120,000x • 3D imaging • Easy to use Great for students, quick checks in QA/QC • Economical $50-80K, on average No need for highly trained operators or special EM suites • “Horses for courses” Expect reasonable imaging but not all the bells and whistles Clarify your requirements before you purchase 7 Desktop SEMs Evex FEI Hitachi JEOL/Nikon NovelX MiniSEM Phenom T1000 NeoScope MySEM Mag. -
Focus on Microscopy Faster, Smaller, More Economical Imaging Tools at SPIE 2007: the Effect of Nanotech by Barbara Foster
Volume 39, Number 20 Focus on Microscopy Faster, Smaller, More Economical Imaging Tools at SPIE 2007: The Effect of Nanotech by Barbara Foster Nanotechnology is having a big effect highlights some of the new technolo- trum from 280 to 720 nm, and provides on imaging equipment. In semiconduc- gies on display during the SPIE exhibit a 20,000-fold light boost. Fast image tor parlance, it is driving a strong “lab to that embody this trend. collection is only part of the story, how- fab” transition: Equipment once found ever. The second half is the challenge of only in the research and development Cameras lead the way, from transferring a quarter of a megabyte of laboratory is now finding its way into data that is being collected 2000 times production. While the more sophisti- 60 to 2000 fps per second. Photron’s solution is 2.6 GB cated laboratory versions retain their Collecting low-light-level images at high of onboard recording memory, enabling role for high precision and applicability speed has long been a challenge for cam- a recording time of 8.2 sec for 1000 fps. to multiple applications, the production era manufacturers. Historically, shutters versions are becoming faster, smaller, on the cameras have been left open to sleeker, and more economical. collect images from dim samples over a New ways to image surface period of time and integrate the result- texture, profi les, and This trend was highly visible at the ing data. By its very nature, however, recent International Society for Opti- this process is slow, and longer integra- roughness cal Engineering (SPIE) meeting, held tion times also result in the collection In the crowded and surging field of August 26–30, 2007, in San Diego, of more stray light and electronic noise. -
Microscopes UMDNS #: 12536 Date of Creation: October 29, 2015 Creator: Complied by Cassandra Stanco for Engineering World Health (EWH)
Equipment Packet: Microscopes UMDNS #: 12536 Date of Creation: October 29, 2015 Creator: Complied by Cassandra Stanco for Engineering World Health (EWH) Equipment Packet Contents: This packet contains information about the operation, maintenance, and repair of laboratory microscopes. Part I: External From the Packet: 1. An Introduction to Microscopes: PowerPoint Part II: Included in this Packet: 1. Operation and Use: a. Introduction to Optical Microscopes (p. 3-12) b. Operation and Use of Microscopes (p. 13-20) 2. Diagrams and Schematics: a. Figure 1: Diagram of a Light Microscope (p. 22) b. Figure 2: Diagram and Parts of a Compound Light Microscope (p. 23) 3. Preventative Maintenance and Safety: a. Microscope Preventative Maintenance (p. 25) 4. Troubleshooting and Repair: a. Microscope Repair and Troubleshooting Flowchart (p. 27-29) 5. Resources for More Information a. Resources for More Information (p. 31) b. Bibliography (p. 32) * * * * 1.*Operation*and*Use*of*Microscopes* * * * Featured*in*this*Section:* * * * WHO.)“Learning)Unit)6:)The)Microscope.”)From)the)Publication:)Basic(Malaria(Microscopy:(part(1.(A( Learner’s(Guide.)WHO:)Switzerland)(2010),)p.)37_44.)Retrieved)from:) http://apps.who.int/iris/bitstream/10665/44208/1/9789241547826_eng.pdfhttp://apps.who. int/iris/bitstream/10665/44208/1/9789241547826_eng.pdf) * * * ) * * * * Optical microscope 1 Optical microscope The optical microscope, often referred to as the "light microscope", is a type of microscope which uses visible light and a system of lenses to magnify images of small samples. Optical microscopes are the oldest and simplest of the microscopes. Digital microscopes are now available which use a CCD camera to examine a sample, and the image is shown directly on a computer screen without the need for optics such as eye-pieces. -
Emerging Optical Nanoscopy Techniques
Nanotechnology, Science and Applications Dovepress open access to scientific and medical research Open Access Full Text Article REVIEW Emerging optical nanoscopy techniques Paul C Montgomery Abstract: To face the challenges of modern health care, new imaging techniques with subcel- Audrey Leong-Hoi lular resolution or detection over wide fields are required. Far field optical nanoscopy presents many new solutions, providing high resolution or detection at high speed. We present a new Laboratoire des Sciences de l’Ingénieur, de l’Informatique et de classification scheme to help appreciate the growing number of optical nanoscopy techniques. l’Imagerie (ICube), Unistra-CNRS, We underline an important distinction between superresolution techniques that provide improved Strasbourg, France resolving power and nanodetection techniques for characterizing unresolved nanostructures. Some of the emerging techniques within these two categories are highlighted with applica- tions in biophysics and medicine. Recent techniques employing wider angle imaging by digital holography and scattering lens microscopy allow superresolution to be achieved for subcellular For personal use only. and even in vivo, imaging without labeling. Nanodetection techniques are divided into four subcategories using contrast, phase, deconvolution, and nanomarkers. Contrast enhancement is illustrated by means of a polarized light-based technique and with strobed phase-contrast Video abstract microscopy to reveal nanostructures. Very high sensitivity phase measurement using interfer- -
The Joint Nanotec 04/ GDR-E Meeting Has Been Organized Under the Authority of the CNRS (Centre National De La Recherche Scientifique) and the University of Nantes
The joint Nanotec 04/ GDR-E meeting has been organized under the authority of the CNRS (Centre National de la Recherche Scientifique) and the University of Nantes. Their contribution is greatly acknowledged. We would like also to thank the Institutions and the companies for their financial support: - Conseil Régional des Pays de la Loire - Conseil Général de Loire Atlantique - DGA (Direction générale pour l'Armement) - Bruker Biospin SA - Leica Microsystems - Jobin Yvon-Horiba - Nanocyl - ADB (Atlantique Dessin Bureau Saint Nazaire) - Snecma - Timcal - SGL Carbon All the work of the members of the organizing committee has been highly appreciated and more specially the contribution of: - Annie Simon (secretary) - Jean-Charles Ricquier (Web Master) - Jean-Pierre Buisson (abstract book) Serge Lefrant Local chairman 4th meeting NanoteC 04 Batz-sur-Mer, 2004 October 10-13 NANOTEC 04 PLANNING 4th meeting NanoteC 04 Batz-sur-Mer, 2004 October 10-13 Sunday, October 10 13h 30 – 17h 45 Registration 17h 45 NanoteC’04 Welcome 18h 00 – 19h 30 : Plenary Lectures (PL) Chairman : F. Béguin 18h 00 – 18h 45 : Invited Large scale synthesis, selective fabrication and applications of carbon nanotubes Morinobu Endo 18h 45 – 19h 30 : Invited New Directions of Carbon Nanotube Science : Importance of Defects and Doping M. Terrones, J.-C. Charlier, V. Meunier, E. Hernández, J. Rodríguez-Manzo, F. López-Urías, A.H. Romero, M. Reyes-Reyes, M. S. Dresselhaus, H. Terrones 19h 30 Welcome Party 20h 00 – 21h 30 Dinner : “Buffet de la Presqu’ile” Monday, October 11 8h 30 – 10h 30 : Session O1 Control and Synthesis of Nanomaterials (I) Chairman : S. Lefrant 8h 30 – 9h 00 : Invited Plasma technology: from carbon blacks to fullerenes and nanotubes E. -
Study of Optical Metallurgical Microscope Pdf
Study of optical metallurgical microscope pdf Continue INDIAN INSTITUTE OF TECHNOLOGY KANPUR Division of Materials and Metallurgical Engineering Virtual Laboratories for Thermal Processing and Materials Characteristics Experiment 1 Microstructure Observation in Light-Optical Microscope Targets Of this laboratory is (i) familiarized with the functioning of the metallurgical microscope, and (ii) observe and interpret the microstructures of these samples. The theory of the microscope function is to turn an object into an image that usually increases to varying degrees. There are many complex techniques (such as electron microscopy) available to perform this transformation. However, the principles involved are just like those developed for light microscopes as far back as 4 centuries ago. The basic concept of any visualization system can be understood from the point of view of a light-optical microscope. The simplest optical microscope is a single convex lens or magnifying lens. There are two important classes of optical microscopes: the type of transmission and the type of reflection of microscopes. Optical mechanisms for these two classes of microscopes are shown in drawings 1.1a and 1.1b. The same two types occur in electron microscopy, which leads to the transmission of electron microscopy and scanning electron microscopy. An integral part of the optical microscope is the lighting system, which consists of a light source and a capacitor lens. The purpose of the capacitor is to focus the diverging beam of light from the source on a small portion of the sample (object A) studied. Most light microscopes use a two- lens system: the lens lens and the eyepiece (often referred to as the projector lens). -
Fingering Instabilities in Dewetting Nanofluids
PHYSICAL REVIEW LETTERS week ending PRL 100, 176102 (2008) 2 MAY 2008 Fingering Instabilities in Dewetting Nanofluids E. Pauliac-Vaujour, A. Stannard, C. P. Martin, M. O. Blunt, I. Notingher, and P.J. Moriarty The School of Physics and Astronomy, The University of Nottingham, Nottingham NG7 2RD, United Kingdom I. Vancea and U. Thiele School of Mathematics, Loughborough University, Leicestershire LE11 3TU, United Kingdom Max-Planck-Institut fu¨r Physik komplexer Systeme, No¨thnitzer Strasse 38, 01187 Dresden, Germany (Received 18 January 2008; published 30 April 2008) The growth of fingering patterns in dewetting nanofluids (colloidal solutions of thiol-passivated gold nanoparticles) has been followed in real time using contrast-enhanced video microscopy. The fingering instability on which we focus here arises from evaporatively driven nucleation and growth in a nano- scopically thin precursor solvent film behind the macroscopic contact line. We find that well-developed isotropic fingering structures only form for a narrow range of experimental parameters. Numerical simulations, based on a modification of the Monte Carlo approach introduced by Rabani et al. [Nature (London) 426, 271 (2003)], reproduce the patterns we observe experimentally. DOI: 10.1103/PhysRevLett.100.176102 PACS numbers: 68.05.Cf, 61.46.Df, 68.08.Bc A remarkable variety of systems in nature form striking substrates. Following solvent evaporation, the nanopar- branched structures which exhibit fractal properties [1,2]. ticles form a broad variety of self-organized patterns on Key examples include river beds [3], snowflakes [4], bac- the surface [15–18]. We carried out the deposition using a terial populations [2], and the ‘‘viscous fingering’’ patterns simple strategy which exploits the affinity of the solvent which form at the interface of fluids of different viscosity with a Teflon ring to form a meniscus of solution [19]. -
Optical Microscope.Pdf
Optical microscope 1 Optical microscope The optical microscope, often referred to as the "light microscope", is a type of microscope which uses visible light and a system of lenses to magnify images of small samples. Optical microscopes are the oldest and simplest of the microscopes. Digital microscopes are now available which use a CCD camera to examine a sample, and the image is shown directly on a computer screen without the need for optics such as eye-pieces. Other microscopic methods which do not use visible light include scanning electron microscopy and transmission electron microscopy. Optical configurations There are two basic configurations of the conventional optical microscope in use, the simple (one lens) and compound (many lenses). Digital microscopes are based on an entirely different system of collecting the reflected light from a sample. Light microscope A simple microscope is a microscope that uses only one lens for magnification, and is the original light microscope. Van Leeuwenhoek's microscopes consisted of a small, single converging lens mounted on a brass plate, with a screw mechanism to hold the sample or specimen to be examined. Demonstrations [1] by British microscopist have images from such basic instruments. Though now considered primitive, the use of a single, convex lens for viewing is still found in simple magnification devices, such as the magnifying glass, and the loupe. Light microscopes are able to view specimens in color, an important advantage when compared with electron microscopes, especially for forensic analysis, where blood traces may be important, for example. History It is difficult to say who invented the compound microscope. -
Communication 0100
COMMUNICATIONUS009731012B2 0100 (12 ) United States Patent (10 ) Patent No. : US 9 , 731, 012 B2 Arany et al. ( 45) Date of Patent: Aug . 15 , 2017 ( 54 ) LASER -ACTUATED THERAPEUTIC .. .. .. .. .. .. .. .. .. .. .. .. 424 / 400 ; 514 / 1 . 1 , 8 . 9 NANOPARTICLES See application file for complete search history . (71 ) Applicant : President and Fellows of Harvard (56 ) References Cited College, Cambridge , MA (US ) U . S . PATENT DOCUMENTS (72 ) Inventors: Praveen Arany , Cambridge , MA (US ) ; 2010 /0183728 Al * 7 /2010 Desai .. .. .. A61K 9 /0019 David J . Mooney , Sudbury , MA (US ) 424 /489 2010/ 0196490 A1 * 8 / 2010 Desai .. A61K 9 /0019 (73 ) Assignee : President and Fellows of Harvard 424 / 489 College , Cambridge , MA (US ) 2010 /0226996 A1* 9 / 2010 Desai A61K 9 /0019 424 /499 2012 /0076862 A1* 3 /2012 Desai . .. .. .. .. A61K 31 / 337 ( * ) Notice : Subject to any disclaimer , the term of this 424 / 491 patent is extended or adjusted under 35 2013 /0231287 A1 * 9 /2013 Nacharaju . .. .. A61K 47 /48215 U . S . C . 154 ( b ) by 98 days. 514 / 15 . 2 (21 ) Appl. No .: 14 / 389 , 136 OTHER PUBLICATIONS (22 ) PCT Filed : Mar . 12 , 2013 Arany et al. , Wound Repair Regen , 15 ( 6 ) :866 - 74 . (2007 ) “ Activa tion of latent TGF- betal by low -power laser in vitro correlates with ( 86 ) PCT No. : PCT/ US2013 / 030493 increased TGF -betal levels in laser -enhanced oral wound healing .” Arany , P . R ., Proceedings of Light- Activated Tissue Regeneration $ 371 ( c ) ( 1 ) , and Therapy Conference Lecture Notes in Electrical Engineering ( 2 ) Date : Sep . 29 , 2014 vol . 12 , pp . 207 - 212 . ( 2008 ) “ Photobiomodulation by Low Power Laser Irradiation Involves Activation of Latent TGF -B1 ” .