Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000971295Cyc: Devosia epidermidihirudinis E84 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

RS06150 RS12955 TrkD RS11615 RS15810 RS11365 RS11290 RS11165 RS07705 RS05785 RS03390 RS10640 CobD RS17455 RS14945 RS00945 RS00805 YejB RS02090 YajC RS13620 RS08710 CysA RS06300 RS14000 RS06930 RS13875 RS06915 RS06215 ArsB RS00420 RS05185 RS06210 SecY RS00490 RS13915 RS06260 RS14010 RS14120 RS08520 RS13535 RS13725 TatC SecA MacB RS16730 RS16965 RS03310 RS10470 RS02410 RS03365 RS00125 RS12050 RS07730 RS15485 RS12045 RS12185 RS15915 RS02770 RS12830 RS13080

RS06160 RS02150

Polyprenyl Biosynthesis Amino Acid Degradation Aminoacyl-tRNA Charging glutaminyl-tRNA gln Macromolecule Modification tRNA-uridine 2-thiolation ATP di-trans,octa-cis UDP-N-acetyl- ditrans,octacis- a peptidoglycan with ditrans,octacis- ditrans,octacis- a [glutamine (4R)-4-hydroxy- DNA with an N-terminal- biosynthesis via transamidation and selenation (bacteria) a [glutamine- an L-cysteinyl- di-trans,poly-cis biosynthesis L-leucine degradation I -undecaprenyl α-D-muramoyl- undecaprenyldiphospho- (L-alanyl-γ-D-glutamyl- undecaprenyldiphospho- undecaprenyldiphospho- synthetase]-O 2-oxoglutarate :7,8- L-methionyl-L- 3',5'-ADP L-tyrosine degradation I L-histidine L-proline degradation I L-glutamate L-citrulline degradation ATP [tRNA Cys ] dGDP RS06245 RS15765 Degradation phosphate γ β L-lysyl-D-alanyl-D- synthetase]- 4 -(5'-adenylyl) seryl-[protein] -undecaprenyl degradation VI phospho-N- L-alanyl- -D- N-acetyl-(N-acetyl- -D- N-acetyl-(N- N-acetyl-(N- dihydro-8- 3'(2'),5'- glu cys degradation II L-tyrosine class 1b phosphate biosynthesis acetylmuramoyl- glutamyl-meso-2,6- glucosaminyl)muramoyl- alanine) pentapeptide acetylglucosaminyl) acetylglucosaminyl) -L-tyrosine oxoguanine bisphosphate ADP leu (to pyruvate) bifunctional ribonucleoside- (2E,6E)-farnesyl pro glycerol and glycerophosphodiester degradation pentapeptide- diaminopimeloyl- L-alanyl-γ-D-glutamyl-L- muramoyl-L-alanyl-γ- muramoyl-L-alanyl- mismatch nucleotidase IPP cysteine F0F1 ATP branched-chain tyr his L-citrulline 4-hydroxy-2- type I methionyl aminoacyl-tRNA diphosphate diphosphate bifunctional glu : D-alanyl-D-alanine lysyl-D-alanyl-D-alanine D-isoglutaminyl-N-(β- γ-D-isoglutaminyl- bifunctional [glutamine CysQ: desulfurase: synthase: amino acid aspartate/ ornithine bifunctional [glutamine oxoglutarate aminopeptidase: : reductase: RS14015 FlgK gln proline glycerol WH87_RS16315 D-asparaginyl)-L-lysyl- N-(β-D-asparaginyl) synthetase] WH87_RS14290 sufS WH87_RS17935 aminotransferase: tyrosine/aromatic carbamoyltransferase: synthetase] aldolase/2- A/G-specific map WH87_RS13215 nrdF nrdE dehydrogenase/L- D-alanyl-D-alanine -L-lysyl-D-alanine adenylyltransferase/ an L-glutamyl- isoprenyl an [L-cysteine atpD WH87_RS11790 aminotransferase: argF monofunctional adenylyltransferase/ dehydro-3-deoxy- adenine type I methionyl aminoacyl-tRNA 3'(2'),5'- transferase: 4-methyl-2- 3-(4- urocanate glutamate gamma- carbamoyl phosphate [glutamine synthetase]- vitamin B12- [tRNA Gln ] imidazole desulfurase]-S- WH87_RS17945 WH87_RS17335 biosynthetic [glutamine synthetase]- phosphogluconate glycosylase: aminopeptidase: hydrolase: bisphosphate WH87_RS03710 oxopentanoate hydroxyphenyl) semialdehyde adenylyl-L-tyrosine adenylyl-L-tyrosine dependent glycerol sulfanyl-L-cysteine WH87_RS17950 urocanate a glycerophosphodiester peptidoglycan monofunctional monofunctional aldolase: eda WH87_RS00850 map WH87_RS12600 nucleotidase Asp-tRNA(Asn) pyruvate dehydrogenase (2S, 3S)-3- glutamine-hydrolyzing : ribonucleotide RS06295 RS15880 phosphate WH87_RS17955 glycerol undecaprenyldiphospho- UMP transglycosylase: biosynthetic biosynthetic phosphorylase: A/G-specific CysQ: cysQ /Glu-tRNA(Gln) di-trans,octa-cis hydratase: PutA: putA methylaspartate carbamoyl-phosphate WH87_RS06650 reductase: synthase: (S)-1-pyrroline- N-acetylmuramoyl-L- mtgA peptidoglycan peptidoglycan WH87_RS06650 amidotransferase: -undecaprenyl [+ 2 isozymes] WH87_RS11020 synthase small glycerophosphodiester adenine an N-terminal WH87_RS07555 hisF hisH alanyl-γ-D-glutamyl-meso transglycosylase: transglycosylase: Cys AMP a [TusA - ATP 3-methylbutanoyl- 4-imidazolone- 5-carboxylate phosphodiesterase: glycerol glyoxylate pyruvate glycosylase: met L-seryl-[protein] cys a tRNA gatC gatA gatB diphosphate subunit: carA a [glutamine GDP [+ 6 isozymes] carrier protein]-S- CoA WH87_RS05735 -2,6-diaminopimeloyl- a peptidoglycan with di-trans,octa-cis mtgA mtgA a [glutamine- WH87_RS01205 a 5-phosphooxy- undecaprenyl- homogentisate 5-propanoate carbamoyl-phosphate GlpK: glpK sulfanyl-L-cysteine D-alanyl-D-alanine (L-alanyl-γ-D-glutamyl- -undecaprenyl synthetase]-O synthetase]- RS14110 L-glutamyl- diphosphate 4 ADP ammonium mesaconate synthase large -(5'-adenylyl) [tRNA Gln ] phosphatase: L-lysyl-D-alanyl-D- diphosphate a peptidoglycan di-trans,octa-cis a peptidoglycan di-trans,octa-cis L-tyrosine subunit: carB sn-glycerol 3-phosphate -L-tyrosine an apurinic site WH87_RS09520 L-glutamate-5- alanine) pentapeptide dimer (E. faeciums) -undecaprenyl dimer (E. faecium -undecaprenyl 3-methylcrotonyl- semialdehyde adenine within DNA Asp-tRNA(Asn) di-trans,octa-cis a [TusD sulfur- N-formimino- carbamate diphosphate , tetrapeptide) diphosphate CoA 4-maleyl- glycerol-3-phosphate /Glu-tRNA(Gln) -undecaprenyl carrier protein]-S- L-glutamate bifunctional RS08720 acetyl/propionyl/ acetoacetate dehydrogenase: amidotransferase: phosphate sulfanyl-L-cysteine proline methylcrotonyl- (S)-citramalate WH87_RS17270 gatC gatA gatB dehydrogenase/L- a ring-opened 7- a reduced ditrans,octacis- a mature a peptide with CoA carboxylase an N-modified a ribonucleoside an L-asparaginyl- UDP glutamate gamma- DHAP methylguanine adenosylcobinamide a purine ubiquinone-6 electron-transfer undecaprenyldiphospho- peptidoglycan leukotriene-D4 an N-terminal (n) aminoacyl-[tRNA] diphosphate [tRNA Asn ] dADP subunit alpha: citramalate CO in DNA ribonucleoside class 1b an L-glutaminyl- a [TusE sulfur 4-fumaryl- N-formyl- semialdehyde 2 flavoprotein N-acetyl-(N- (meso-DAP class 1b L- RS08785 Gln WH87_RS09940 synthase: 5'-triphosphate ribonucleoside- class 1b [tRNA ] acetoacetate L-glutamate dehydrogenase acetylglucosaminyl) containing) 34 carrier protein]-S ribonucleoside- diphosphate tRNA charging a uridine in tRNA 3-methylglutaconyl- PutA: putA WH87_RS06470 electron transfer muramoyl-L-alanyl-γ-D- membrane ribonucleoside- -sulfanylcysteine fumarylacetoacetate N-formylglutamate bifunctional DNA- aminoacyl-tRNA diphosphate aminoacyl-tRNA type I methionyl reductase: CoA bifunctional flavoprotein- isoglutaminyl-L-lysyl- dipeptidase: diphosphate hydrolase: amidohydrolase: Aldehyde Degradation formamidopyrimidine lytic hydrolase: reductase: hydrolase: aminopeptidase: nrdF nrdE glu adenosylcobinamide ubiquinone (glycyl) -D-alanyl-D-alanine WH87_RS15310 reductase: glu tRNA 2- WH87_RS10765 acetate pyruvate glycosylase/ 5 WH87_RS13215 nrdF nrdE WH87_RS13215 map glu a tRNA WH87_RS02550 kinase/ transglycosylase membrane vitamin B12- nrdF nrdE RS08845 Gly thiouridine(34) DNA-(apurinic : gly a tRNA fumarylacetoacetate glycine cleavage methylglyoxal degradation I adenosylcobinamide- domain-containing aminoacyl-tRNA dipeptidase: vitamin B12- aminoacyl-tRNA type I methionyl dependent synthase glu or apyrimidinic WH87_RS00785 vitamin B12- phe a tRNA Phe tRNA asp asp ser a tRNA ser a tRNA Ala ala hydrolase: phosphate monofunctional protein: hydrolase: WH87_RS07805 dependent hydrolase: aminopeptidase: ribonucleotide elongator glutamate-- MnmA: mnmA HMG-CoA a [glycine-cleavage site) : mutM electron transfer dependent met initiator tRNA Met met arg a tRNA Arg val a tRNA Val cys a tRNA Cys pro a tRNA Pro tyr a tRNA Tyr trp a tRNA Trp thr a tRNA Thr lys a tRNA Lys his a tRNA His ile a tRNA Ile leu a tRNA Leu WH87_RS11965 : biosynthetic WH87_RS10055 WH87_RS12600 ribonucleotide WH87_RS12600 map reductase: tRNA Met tRNA : complex H protein] N 6 methylglyoxal flavoprotein- ribonucleotide glycine-- cobU peptidoglycan [+ 4 isozymes] reductase: WH87_RS07555 Asn Gln 34 L-methionine degradation lactoylglutathione reductase: RS13625 phenylalanine- asn tRNA gln a tRNA aspartate- WH87_RS03665 serine- tRNA ligase alanine- a 2-thiouridine fumarate -[(R)-lipoyl]-L-lysine glycine cleavage system a [DNA]- 2,6-diamino-4- ubiquinone transglycosylase: WH87_RS07555 I (to L-homocysteine) a 5'-phospho- adenosyl- leukotriene-E4 gly a 2'- WH87_RS07555 in tRNA lyase: 4-oxo-2-pentenal oxidoreductase: an N-modified an uncharged Asn dUDP -tRNA ligase: -tRNA methionine-- methionine-- glutamate-- -tRNA arginine-- valine-- cysteine-- proline-- tyrosine-- tryptophan- threonine- subunit beta: -tRNA lysine-- histidine-- isoleucine-- leucine-- aminomethyltransferase nucleotide- [DNA] hydroxy-5-(N-methyl) mtgA a mature GlcNAc-1,6- deoxyribonucleoside asn tRNA met a peptide tRNA uridine-5- glycine cleavage system WH87_RS12860 cobinamide WH87_RS01270 amino acid tRNA ADP WH87_RS09405 ligase: tRNA ligase: tRNA ligase: tRNA ligase: ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: -tRNA -tRNA WH87_RS14350 ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: acetoacetate L-serine degradation GcvT: gcvT 3'-phosphate formamidopyrimidine a purine peptidoglycan anhMurNAc- 5'-diphosphate carboxymethylaminomethyl(34) met aminomethyltransferase [+ 3 isozymes] phosphate (n) pheS aspS WH87_RS03280 WH87_RS03280 WH87_RS06495 serS WH87_RS04510 WH87_RS04545 WH87_RS06455 WH87_RS07135 WH87_RS07440 ligase: trpS ligase: thrS [+ 2 isozymes] alaS WH87_RS16910 WH87_RS17430 WH87_RS17520 WH87_RS18535 [+ 5 isozymes] (R)-S- ribonucleoside a peptidoglycan di-trans,octa-cis (meso-DAP L-Ala-γ-D-Glu- synthesis MnmG: mnmG methionine GcvT: gcvT an oxidized F0F1 ATP RS13685 lactoylglutathione 5'-diphosphate + dimer (S. aureus) -undecaprenyl containing) DAP-D-Ala + + an L-methionyl- ser adenosyltransferase: [+ 5 isozymes] electron-transfer H ubiquinol-6 H synthase H an L-phenylalanyl- an L-asparaginyl- an L-glutaminyl- an L-aspartyl- an L-methionyl- an L-glutamyl- an L-seryl- an L-arginyl- an L-valyl- an L-cysteinyl- an L-prolyl- an L-tyrosyl- an L-tryptophanyl- an L-threonyl- an L-alanyl- an L-lysyl- an L-histidyl- an L-isoleucyl- an L-leucyl- tRNA uridine-5- diphosphate [elongator a glycyl-[tRNA Gly ] L-serine WH87_RS09215 hydroxyacylglutathione flavoprotein [tRNA Phe ] [tRNA Asn ] [tRNA Gln ] [tRNA asp ] [initiator tRNA Met ] [tRNA Glu ] [tRNA ser ] [tRNA Arg ] [tRNA Val ] [tRNA Cys ] [tRNA Pro ] [tRNA Tyr ] [tRNA Trp ] [tRNA Thr ] [tRNA Ala ] [tRNA Lys ] [tRNA His ] [tRNA Ile ] [tRNA Leu ] carboxymethylaminomethyl(34) Met SAM hydrolase: gloB tRNA ] synthesis GTPase MnmE: mnmE L-arginine degradation ammonia-lyase: a [glycine-cleavage a [glycine-cleavage 6 ATP F0F1 VII (arginase 3 pathway) 2-aminoprop-WH87_RS02755 6 complex H protein] N - α + + a 5-carboxymethylaminomethyl- complex H protein] N (R)-lactate a 7,8-dihydro- UDP-N-acetyl- -D- 3-benzyl-3,6 - an N-terminal- UDP-N-acetyl- an N-terminal- an N-terminal- a [protein]-L- dCDP a [protein]-L- H synthase H RS13720 aminomethyldihydrolipoyl- + 5 34 2-enoate -dihydrolipoyl-L-lysine 8-oxoguanine muramoyl-L-alanyl- NADPH NAD bis(cysteinylglycine) L-methionyl-L- α D-glt L-methionyl-L- L-methionyl-L- glutamate-O 2-thiouridine in tRNA L-lysine dGTP -D-muramoyl- class 1b methionine arg in DNA γ-D-glutamyl-meso- - 6-(hydroxymethyl) cysteinyl-[protein] alanyl-[protein] valyl-[protein] -methyl-ester peptide- D-alanyl-D-alanine L-alanine ribonucleoside- 2,6-diaminopimelate methionine F0F1 ATP , Carrier, and Vitamin Biosynthesis -diketopiperazine + + SAH NAD(P)(+) diphosphate (S)-S-oxide H synthase H bifunctional DNA- type I methionyl UDP-N- type I methionyl type I methionyl chemotaxis a 5-aminomethyl-2- pyruvate transhydrogenase reductase: reductase RS00355 cob(II)yrinate a,c- arginase: rocF 2-iminopropanoate L-glutamine formamidopyrimidine dNTP UDP-N- membrane aminopeptidase: acetylmuramoyl- aminopeptidase: aminopeptidase: response 34 (Re/Si-specific): nrdF nrdE cob(II)yrinate a,c-diamide [2Fe-2S] iron-sulfur ubiquinol-8 biosynthesis ubiquinol-8 biosynthesis superpathway of tetrahydrofolate biosynthesis adenosylcobalamin 5-methylbenzimidazolyl adenosylcobamide thiouridine in tRNA adenosylhomocysteinase: degradation I L-aspartate triphosphohydrolase: dgt MsrA: msrA diamide biosynthesis I glycine cleavage glycosylase/ acetylmuramoyl- WH87_RS02170 dipeptidase: map L-alanine-- map map regulator protein- biosynthesis II (late cluster biosynthesis (early decarboxylation) (late decarboxylation) salvage from cobalamin biosynthesis from adenosylcobinamide-GDP WH87_RS10020 degradation I DNA-(apurinic deoxyguanosinetriphosphate tripeptide--D- WH87_RS15310 D-glutamate glutamate vitamin B12- peptide- RS05145 (early cobalt insertion) Secondary Metabolite Biosynthesis urea system protein WH87_RS02175 type I methionyl type I methionyl type I methionyl cobalt incorporation) all-trans- L-ornithine gln triphosphohydrolase: dependent methionine GcvH: gcvH or apyrimidinic alanyl-D- alanine WH87_RS02180 membrane aminopeptidase: ligase: murD aminopeptidase: aminopeptidase: methylesterase: uroporphyrinogen-III chorismate GTP cob(I)alamin 5-methylbenzimidazole L-homocysteine imidazole ribonucleotide RS18440 uroporphyrinogen-III L- 4-hydroxybenzoate octaprenyl a 5-methylaminomethyl- [+ 3 isozymes] asp site) lyase: mutM WH87_RS04515 ligase: murF dipeptidase: map map map cheB (S)-S-oxide uroporphyrinogen-III methylerythritol phosphate pathway I ornithine pyruvate Si-specific NAD(P)(+) reductase: uroporphyrinogen-III diphosphate 34 glycerol aspartate/ reductase C-methyltransferase: nicotinate-nucleotide-- myo-inositol 2-thiouridine in tRNA cyclodeaminase: WH87_RS07805 UDP-N-acetyl- cysteine GTP phosphate tyrosine/aromatic transhydrogenase: WH87_RS07555 MsrA: msrA cobA C-methyltransferase: dimethylbenzimidazole biosynthesis a [DNA]- UDP-N-acetyl-α-D- α-D-muramoyl-L- α a protein-L- desulfurase: 4-hydroxybenzoate cyclohydrolase cob(II)alamin D-glyceraldehyde WH87_RS15510 synthase: a 5'-phospho- 7,8-dihydro- WH87_RS11585 an N-terminal L- an N-terminal L- an N-terminal a [protein]- - CDP cobA 4-hydroxybenzoate pyruvate L-glutamine aminotransferase: nucleotide- 4-oxo-2-pentenal triphosphate muramoyl-L-alanyl- 3-benzyl-3,6 - alanyl-D-glutamate met met MeOH methionine- RS01780 uroporphyrinogen-III sufS octaprenyltransferase: I FolE: folE phosphoribosyltransferase: 3-phosphate D-glucopyranose hisF hisH [DNA] 8-oxoguanine 2'-deoxyguanosine met cysteinyl-[protein] alanyl-[protein] L-valyl-[protein] L-glutamate uroporphyrinogen-III degradation II L-glutamate WH87_RS17335 3'-phosphate γ-D-glutamyl-meso- RS14590 C-methyltransferase: WH87_RS14300 4-hydroxybenzoate 7,8- cob(I)yrinic acid cobT 6-phosphate a 5-methylaminomethyl- pro oxaloacetate bis(cysteinyl)- 6- gly (S)-S-oxide C-methyltransferase: an S-sulfanyl-[L- L-asparagine [+ 6 isozymes] degradation I cobA octaprenyltransferase: dihydroneopterin a,c-diamide 1-deoxy-D- 2-(S-geranyl) 2,6-diaminopimeloyl- NADH NADP + (hydroxymethyl) cobA cysteine desulfurase] adenosylcobinamide- 5-methylbenzimidazole degradation I glu adenosyltransferase: xylulose-5- 34 gln D-alanyl-D-alanine -diketopiperazine CysT precorrin-1 4-hydroxy-3- WH87_RS14300 3'-triphosphate GDP ribotide phosphate thiouridine in tRNA precorrin-1 cobO Ins(3)P glutamate glu octaprenylbenzoate 4-hydroxy-3- phosphate asn FtsA uroporphyrinogen-III synthase: NAD-glutamate RS01395 uroporphyrinogen-III octaprenylbenzoate cob(I)yrinic acid synthase: core M-antigen a DNA containing an N-terminal- an N-terminal- a protein-L- adenosylcobinamide- gltB gltD a [DNA]-3'- + a 5'-phospho- (2E,6E)-farnesyl a nucleoside phosphoenol C-methyltransferase: inositol asparaginase: dehydrogenase: 34 NAD C-methyltransferase: 7,8- a,c-diamide WH87_RS02290 a 5,10-gly a uridine oligosaccharide- (variant) monomer an apurinic/ L-methionyl-L- RNA L-methionyl- oxidized glu methionine- cobA an S-sulfanyl-[cysteine 4-hydroxy-3- GDP a 5-methylaminomethyl- glu hydroxyl [DNA] diphosphate protoheme triphosphate dGDP pyruvate ATP roseoflavin monophosphatase: WH87_RS06985 WH87_RS06380 methylenetetrahydrofolate in tRNA undecaprenyl factor 420-0 cobA desulfurase]-[disordered- octaprenylbenzoate dihydroneopterin adenosyltransferase: ribazoletransferase: 2-(Se-phospho) 2-oxoglutarate lipid A (E. coli apyrimidinic site threonyl-[protein] glycyl-[protein] 5'-phosphate (R)-S-oxide RS13075 uroporphyrinogen-III 1-deoxy-D-xylulose WH87_RS02990 asp peptide- uroporphyrinogen-III form scaffold 2-octaprenylphenol 5-hydroxylase: 3'-phosphate WH87_RS14755 WH87_RS06565 selenouridine 34 in tRNA K-12 core type) diphosphate chorismate [+ 4 isozymes] DNA methionine C-methyltransferase: protein] complex cob(II)alamin- 5-phosphate (no GlcNAc) protoheme IX DNA-directed TauA C-methyltransferase: WH87_RS09495 tRNA uridine-5- ligase endonuclease type I methionyl type I methionyl coenzyme (R)-S-oxide RS12655 cobA 2-polyprenylphenol 3,4-dihydroxy- [corrinoid Coα-[α-(5- farnesyltransferase: RNA bifunctional cobA aminodeoxychorismate/ myo-inositol carboxymethylaminomethyl(34) D: ligD III: nth aminopeptidase: pyruvate aminopeptidase: F420-0:L- reductase 6-hydroxylase: ubiB 5-all-trans- anthranilate synthase adenosyltranferase] methylbenzimidazolyl)]- synthesis enzyme MnmG: mnmG WH87_RS00995 map subunit alpha: map / glutamate precorrin-2 D-erythro-7,8- a 5-methylaminomethyl- O-antigen bifunctional DNA- kinase: pyk MsrB: msrB precorrin-2 3-(all-trans octaprenylbenzoate component II: Coβ-adenosylcobamide NAD- protoheme IX WH87_RS03965 FAD synthetase: ligase: cofE UgpC a [cysteine desulfurase]- dihydroneopterin glutathione- 2-selenouridine 34 tRNA uridine-5- ligase domain- formamidopyrimidine type I methionyl type I methionyl peptide- -octaprenyl) WH87_RS03175 5'-phosphate MEP dependent farnesyltransferase: [+ 2 isozymes] WH87_RS17515 precorrin-2 C(20)- S-sulfanyl-[disordered- peroxide in tRNA carboxymethylaminomethyl(34) containing protein: glycosylase/ aminopeptidase: aminopeptidase: methionine RS10105 benzene-1,2-diol dihydroneopterin cob(I)alamin- DNA ligase WH87_RS01060 MotA methyltransferase: form scaffold aminodeoxychorismate redox reactions synthesis GTPase MnmE: mnmE WH87_RS10815 DNA-(apurinic map pyruvate map oxidized (R)-S-oxide bifunctional 2- aldolase: folB bifunctional 2-C- LigA: ligA roseoflavin WH87_RS00165 protein] complex 3-methoxy-4- synthase component [corrinoid or apyrimidinic dGTP GSSG RNA factor 420-1 reductase sirohydrochlorin cysteine polyprenyl-6- hydroxy-5-all-trans 6-(hydroxymethyl) I: WH87_RS08440 adenosyltranferase] Coα-[α-(5- methyl-D-erythritol di-trans,octa-cis adenine 34 site) lyase: mutM MsrB: msrB precorrin-3A desulfurase: hydroxyphenol cob(I)yrinic acid 4-phosphate Amine and Polyamine Degradation Carbohydrate Degradation a 5-carboxymethylaminomethyluridine E. coli M ferroheme o an N-terminal L- an N-terminal dinucleotide -octaprenylbenzoate -7,8-dihydropterin methylbenzimidazolyl)]- tRNA processing a 7,8-dihydrofolate LPS -undecaprenyl a [protein]-L- UgpC 4-amino-4- in tRNA [DNA] NMN met threonyl-[protein] met glycyl-[protein] RS17190 sufS methylase/3- a,c-diamide Coβ-adenosylcobamide cytidylyltransferase/ diphosphate AMP methionine an S-sulfanyl-[cysteine 2-amino-4-hydroxy-6- deoxychorismate demethylubiquinol 3- adenosyltransferase: glutathione- 2-C-methyl-D- allantoin degradation Entner-Doudoroff pathway I a 3'-terminal a 5'-phospho- RS08070 desulfurase]-S- hydroxymethyldihydropteridine a polycistronic superpathway of N-acetylglucosamine, allantoin degradation cobalt- O-methyltransferase cobO disulfide erythritol 2,4- IV (anaerobic) lactose degradation II melibiose degradation unsaturated sugar [DNA] sulfanyl-[disordered- 2-methoxy-6-(all-trans diphosphokinase: folK tRNA precursor N-acetylmannosamine and N- to glyoxylate I sirohydrochlorin UbiG: ubiG (7,8-dihydropterin- cob(I)yrinic acid reductase: cyclodiphosphate D-glucopyranose precorrin-3B form scaffold 2-methoxy- -octaprenyl)phenol acetylneuraminate degradation RS08100 6-yl)methyl a,c-diamide gor synthase: (S)-(+)-allantoin 6-phosphate α-lactose melibiose an O 4 - an [amino-group RS17380 protein] complex 4-aminobenzoate N-acetylneuraminate (S)-(+)-allantoin a purine base a single a [protein]- a [protein]- a DNA methyl phosphoenol L-rhamnulose 6-(all-trans- 2-octaprenyl-6- diphosphate adenosyltransferase: WH87_RS03560 methylthymine H O a cytidine 34 precorrin-3B C(17)- allantoinase glucose-6- lesion in DNA stranded DNA L-cysteine L-cysteine phosphotriester SAH 2 a tRNA precursor pyruvate 1-phosphate lys carrier protein]- octaprenyl)phenol methoxyphenyl allantoinase GTP dADP ATP Ile2 RS11610 methyltransferase: WH87_RS14755 4-(cytidine 5'- phosphate in DNA biotin in tRNA C-terminal-γ- 2-octaprenyl-6- hydroxylase: a tRNA precursor a tRNA precursor PuuE: puuE alpha-glucosidase/alpha- cobalt-factor III WH87_RS00170 dihydropteroate adenosylcob(III) glutathione diphospho)-2-C- PuuE: puuE N-acetyl-D- dehydrogenase: 3'-ketolactose (L-glutamate 5- methoxyphenyl WH87_RS09495 with a 5' with a 5' allantoate galactosidase: melA bifunctional DNA- exodeoxyribonuclease bifunctional a [cysteine synthase: folP alamin-[corrinoid methyl-D-erythritol mannosamine zwf methylated-DNA-- methylated-DNA-- semialdehyde-2-N-acetyl- RS10475 RS16015 hydroxylase: 2-methoxy-6-all extension and extension and a allantoate [+ 2 isozymes] VII large subunit: 5'-methylthioadenosine/ ribosome ribonuclease D: rhamnulose- tRNA precorrin-4 desulfurase]-(S- adenosyltranferase] 4-(cytidine 5'- beta-glucosidase: formamidopyrimidine [protein]-cysteine S- [protein]-cysteine S- biotin--[acetyl- yl)-L-glutamategamma- WH87_RS09495 trans-octaprenyl- a long 3' trailer short 3' extension glucose-6- WH87_RS14270 S-adenosylhomocysteine small subunit- WH87_RS09490 pyruvate 1-phosphate lysidine(34) sulfanyl) -[disordered- 7,8- cob(I)yrinic acid diphospho)- WH87_RS17355 glycosylase/ methyltransferase: methyltransferase: CoA-carboxylase] glutamyl- precorrin-4 C(11)- 2 2-methoxy-6-all 1,4-benzoquinol superpathway of adenosylcobalamin salvage from cobinamide I phosphate nucleosidase: dependent ribonuclease kinase: pyk synthetase form scaffold dihydropteroate a,c-diamide 2-C-methyl-D- 3-keto-β-D- D-galactopyranose D-glucopyranose DNA-(apurinic exodeoxyribonuclease WH87_RS08365 aldolase/ phosphate PhnE trans-octaprenyl- ribonuclease N-acetyl-D- dehydrogenase: WH87_RS13365 WH87_RS07815 D: rnd ligase: TilS: tilS cobalt-precorrin-3 methyltransferase: protein] complex bifunctional : galactose or apyrimidinic VII small subunit: GTPase A: rsgA short-chain an [amino-group 1,4-benzoquinol bifunctional adenosyltransferase: P protein mannosamine (S)-ureidoglycolate zwf methylated-DNA-- methylated-DNA-- WH87_RS07155 reductase: cobM demethylmenaquinone cob(II)inamide WH87_RS00775 site) lyase: mutM WH87_RS00620 [+ 5 isozymes] dehydrogenase: carrier protein]- RS15100 RS12380 bifunctional folylpolyglutamate cobO ribonuclease D: component: (S)-ureidoglycine 6-phosphate 6-phospho [protein]-cysteine S- [protein]-cysteine S- argC methyltransferase/2- ribonuclease pyruvate WH87_RS00040 34 C-terminal-γ- precorrin-5 synthase/ 4-(cytidine 5'- WH87_RS09490 ureidoglycolate methyltransferase: S-ribosyl-L- a nucleoside 5'- a lysidine demethylmenaquinone methoxy-6-polyprenyl- cob(I)yrinic acid a,c-diamide cob(I)yrinic acid D: rnd rnpA putative N- D-glucono- methyltransferase: dATP Ile2 + a tRNA biotinyl-5'- in tRNA (5-phospho- dihydrofolate diphospho)- ribonuclease (S)-ureidoglycine acetylmannosamine- lyase: 1,5-lactone a [DNA]- a 5'-phospho- a modified WH87_RS13365 adenine homocysteine phosphate H monophosphate a [cysteine desulfurase]- methyltransferase/2- 1,4-benzoquinol adenosyltransferase: cobO a,c-diamide ribonuclease D: D-galactopyranose D-mannose degradation 4-oxo-2-pentenal a ribonucleoside a single-stranded WH87_RS08365 GDP adenylate L-glutamyl)- RS11465 precorrin- synthase: 2-C-methyl-D- D: rnd ribonuclease PH: a tRNA precursor aminohydrolase: WH87_RS13135 nucleotide- cobalt-precorrin-4 [scaffold protein- methoxy-6-polyprenyl- methylase UbiE: ubiE cob(I)yrinic acid a,c-diamide adenosyltransferase: WH87_RS09490 6-phosphate 6-phosphogluconolactonase: [DNA] nucleobase 5'-monophosphate oligodeoxyribonucleotide 6A synthase erythritol kinase: WH87_RS08465 with a short WH87_RS13130 3'-phosphate DHAP (S)-lactaldehyde L-glutamate RhaS (2Fe-2S)] complex 1,4-benzoquinol 6-methoxy-3-methyl- WH87_RS09370 adenosyltransferase: WH87_RS14755 2-epimerase: glyoxylate D-mannopyranose a [protein]-S- a [protein]-S- RS12325 (deacetylating): 3' extension pgl a thymine in DNA [DNA] methylase UbiE: ubiE 2-all-trans-octaprenyl- 7,8-dihydrofolate WH87_RS14755 WH87_RS01280 WH87_RS10490 6-phosphate adenosylcobalamin (S)-ureidoglycolate mannose-1-phosphate methyl-L-cysteine methyl-L-cysteine WH87_RS00150 6-methoxy-3- 1,4-benzoquinol monoglutamate 2-phospho-4-(cytidine N-acetyl-D- D-gluconate glucosamine 6-phosphate guanylyltransferase/ precorrin-6A methyl-2-all- [corrinoid adenosyltranferase]-cob(II)inamide 5'-diphospho)-2-C- a tRNA malate/lactate/ malate/lactate/ cobalt- a [co-chaperone]- ribonuclease D: mannose-6- 6 RS03660 trans-octaprenyl- methyl-D-erythritol precursor with ureidoglycolate ureidoglycolate 6-phosphate phosphogluconate a mature peptidoglycan (meso a [protein]- an O - an oxidized β-D-glucose a [DNA]-3'- a 5'-phospho- queuosine at a supercoiled RS06665 precorrin-5A [scaffold protein- ribonuclease PH: WH87_RS09490 phosphate : pyruvate a (6S)-5- a uracil in DNA γ-L-glutamyl- RS11470 1,4-benzoquinol bifunctional 2-C- a 5' extension dehydrogenase: dehydrogenase: N-acetylglucosamine- dehydratase: -diaminopimelate containing) L-cysteine methylguanine glu factor 420 6-phosphate 4-hydroxy-L-threonine hydroxyl [DNA] glu position 34 ala UDP-N-acetyl- gly duplex DNA (2Fe-2S)] complex WH87_RS08465 ribonuclease D-galactose degradation I (Leloir pathway) WH87_RS17105 in DNA formyltetrahydrofolate Asp α D-alanine 3-demethylubiquinol-8 a 7,8-dihydrofolate methyl-D-erythritol WH87_RS08045 WH87_RS08045 6-phosphate WH87_RS17685 of a tRNA -D-muramate DNA superpathway of pyridoxal 5'-phosphate biosynthesis and salvage D: rnd F6P 4-phosphate ribonuclease deacetylase: nagA [corrinoid adenosyltranferase]-cob(I)inamide N-carbamoyl- β-D- lytic transglycosylase pyruvate, glucose-6- uracil-DNA cisplatin damage precorrin-6B bifunctional 2- dihydrofolate cytidylyltransferase/ P protein D-glucosamine KDGP methylated-DNA-- low-specificity glutathione RecQ: cobalt- D-erythrose 2-oxoglycine galactopyranose domain-containing phosphate bifunctional phosphate glycosylase: response ATP- tRNA glutamyl- UDP-N- RS11345 RS02420 a [chaperone-ATP]- 3-demethylubiquinol-8 polyprenyl-6- reductase: 2-C-methyl-D- component: 6-phosphate [protein]-cysteine S- folylpolyglutamate L-threonine synthase: recQ precorrin-5B cob(I)yrinic acid a,c-diamide 4-phosphate aldose 1- protein: dikinase: dehydrogenase WH87_RS00790 dependent Q(34) synthetase acetylmuramate-- RS12180 [co-chaperone]- hydroxyphenol WH87_RS16165 erythritol 2,4- rnpA methyltransferase: synthase/ aldolase: ltaE gshB ATP- adenosyltransferase: cobO protein S-nitrosylation bifunctional epimerase: WH87_RS10055 WH87_RS00705 (coenzyme- DNA ligase: GluQRS: L-alanine ligase: [scaffold protein- bifunctional 2- methylase/3- [+ 2 isozymes] cyclodiphosphate WH87_RS13365 uracil-DNA dependent cob(I)yrinic acid a,c-diamide and denitrosylation 4-hydroxy-2- [+ 4 isozymes] dihydrofolate F420): fgd WH87_RS02455 WH87_RS14660 WH87_RS16300 (2Fe-2S)] complex polyprenyl-6- demethylubiquinol 3- synthase: allantoin degradation WH87_RS00440 glycosylase: α methylated-DNA-- synthase: DNA precorrin-7 hydroxyphenol a tetrahydrofolate adenosyltransferase: 4-phospho- WH87_RS03560 a [protein]- -D-glucosamine to glyoxylate III oxoglutarate [+ 2 isozymes] phosphoenol WH87_RS01265 glycolaldehyde RS10675 cobalt- O-methyltransferase carbamoyl + [protein]-cysteine S- WH87_RS09370 norophthalmate helicase WH87_RS14755 oxamate 6-phosphate aldolase/2- α a mature peptidoglycan a mature peptidoglycan strand diphosphate H gly glutamyl- UDP-N-acetyl- RS11305 methylase/3- UbiG: ubiG D-erythronate L-cysteine phosphate -D- pyruvate 6-phospho RecG: recG precorrin-6A 2-C-methyl-D-erythritol- γ AMP methyltransferase: a reduced queuosine at α-D-muramoyl- RS05905 demethylubiquinol 3- glucosamine- (S)-(+)-allantoin dehydro-3-deoxy- galactopyranose with (L-alanyl- -D-glutamyl- (non-reducing terminus) D-glucono- [DNA] a single cobalt-precorrin- adenosylcobinamide 2,4-cyclodiphosphate WH87_RS08365 factor 420 an apyrimidinic uracil position 34 L-alanine a [chaperone- O-methyltransferase ubiquinol-8 glutamine- 6-phosphate allantoinase phosphogluconate meso-2,6-diaminopimeloyl- a (6S)-5- 1,5-lactone stranded DNA 6A reductase: an uncharged glycogen degradation II site in DNA Asp an [2Fe-2S] flavodoxin- hydrolyzing PuuE: puuE aldolase: eda D-alanine) tetrapeptide formyltetrahydrofolate of a tRNA WH87_RS17640 ADP]-[disordered- UbiG: ubiG bifunctional tRNA a [protein] 3- deaminase: a [protein]-S- RS07580 precorrin-8x cluster protein form scaffold adenosylcobinamide (3R)-3-hydroxy-2-oxo- dependent carbamoyl- WH87_RS06130 allantoate a guanine in DNA cobalt- nitrosothio- α-D-galactose a glycogen methyl-L-cysteine RS15730 protein] complex ubiquinol-8 menaquinol-7 biosynthesis kinase/adenosylcobinamide- 4 phosphooxybutanoate (E)-4-hydroxy- phosphate D-glyceraldehyde UDP-α-D-glucose FliQ precorrin-6B precorrin-8X L-alanine synthase F6P pyruvate 1-phosphate phosphate phosphoserine 3-methylbut- 3-phosphate glycogen/starch/ methylmutase: all-trans- D-glyceraldehyde pyruvate transaminase: 2-enyl- small a nascent peptidoglycan a 3-methyl- lipid II (meso a [protein chain (E)-4-hydroxy-3- WH87_RS00160 NAD de novo biosynthesis 1,4-dihydroxy- guanylyltransferase: cobU 3-phosphate type I alpha-glucan 3'-dephospho- a mismatched (S)-1-pyrroline- an L-cysteinyl- heptaprenyl WH87_RS01815 subunit: carA a lipid II a peptidoglycan 2-oxoglutarate β 1-butanesulfonate acetyl-CoA RS10800 I (from aspartate) diphosphate glyceraldehyde- phosphorylase: (meso-DAP containing) branched diaminopimelate (R)- -lysine elongation factor methylbut-2-en- Pro an [Fe-S cluster diphosphate 2-naphthoate ATP CoA DNA base pair 5-carboxylate [tRNA ] (S)-ureidoglycine 34 1-yl diphosphate hydrogenobyrinate adenosyl-cobinamide phosphate 1-deoxy-D- 4-phosphooxy- synthase: ispG carbamoyl- 3-phosphate glgP 2,3,4-saturated containing) EF-P]-L-lysine DNA bifunctional flavodoxin- acetyl-CoA cobalt-precorrin-7 biosynthesis a [protein]- RS11920 RS11285 5,6-dimethylbenzimidazole xylulose-5- L-threonine (E)-4-hydroxy-3- S-nitrosoglutathione phosphate dehydrogenase: UDP- fatty acyl-CoA mismatch proline carboxylase chaperone]-ATP asp L-cysteine (S)-ureidoglycine an α-limit dextrin lytic transglycosylase monofunctional FMNH2-dependent dependent bifunctional phosphate 4-hydroxythreonine- methylbut-2-en- synthase urea degradation II gap glucose 4- monofunctional repair protein dehydrogenase/L- biotin carboxyl Cys- bifunctional cobalt- L-aspartate nicotinate-nucleotide-- aminohydrolase: domain-containing biosynthetic phytanoyl-CoA EF-P lysine alkanesulfonate (E)-4-hydroxy- adenosylcobinamide 4-phosphate 1-yl diphosphate S-(hydroxymethyl) large epimerase biosynthetic dephospho- MutS: mutS glutamate gamma- carrier precorrin-7 (C(5))- oxidase: synthase: WH87_RS13130 protein: peptidoglycan dioxygenase: aminoacylase monooxygenase: 3-methylbut- tRNA(Pro) RS07615 dimethylbenzimidazole kinase/adenosylcobinamide- glutathione 13-DPG GalE: galE CoA kinase: semialdehyde protein: accB hydrogenobyrinate WH87_RS02700 demethylmenaquinol-7 WH87_RS02290 dehydrogenase subunit: carB urea WH87_RS10055 transglycosylase: WH87_RS03875 peptidoglycan GenX: genX DNA mismatch 2-enyl- deacylase: methyltransferase/ phosphoribosyltransferase: dehydrogenase/ ssuD a,c-diamide 2-iminosuccinate phosphate PdxA: pdxA urease: (S)-ureidoglycolate transglycosylase: coaE repair dehydrogenase diphosphate [+ 3 isozymes] ybaK RS15475 cobalt-precorrin- cobT 4-hydroxy- queuosine a debranched [+ 4 isozymes] mtgA phytanoyl-CoA RS05840 bifunctional guanylyltransferase: cobU 1-deoxy-D- 3-amino-1- class III alcohol carbamate mtgA PutA: putA 6B (C(15))- cobaltochelatase 3-methylbut- WH87_RS11825 phosphoglycerate α-limit dextrin dioxygenase: [a protein chain protein MutS: 2-C-methyl-D-synthase: ispG malonyl-CoA quinolinate demethylmenaquinone hydroxyacetone biosynthesis I (de novo) dehydrogenase: ureidoglycolate methyltransferase: subunit CobN: cobN α-ribazole 5'-phosphate xylulose 5- 2-enyl WH87_RS11835 kinase: pgk di-trans,octa-cis elongation factor 1-butanal sulfite WH87_RS18625 synthase methyltransferase/2- adenosylcobinamide-GDP WH87_RS07985 lyase: α-D- a mature peptidoglycan a nascent peptidoglycan WH87_RS14315 H + glu erythritol-2,4- RS07645 phosphate 1-phosphate 4-hydroxy- ureC UDP-α-D- a peptidoglycan a properly matched Pro WH87_RS00175 cobaltochelatase: diphosphate preQ 3-phospho- glycogen/starch/ glucan 1,4-alpha- with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) -undecaprenyl lipid II (meso di-trans,octa-cis EF-P]-N-(β-L- ADP cyclodiphosphate cys a tRNA NadA: nadA methoxy-6-polyprenyl- 0 WH87_RS13135 glucopyranose a 2-hydroxy-3- DNA base pair 3-methylbut- S-(hydroxysulfenamide) ammonium galactose 34 cobT cobS reductase: D-glycerate alpha-glucan glucosidase: meso-2,6-diaminopimeloyl- with GlcNAc terminus diphosphate diaminopimelate -undecaprenyl lysyl)-L-lysine 1,4-benzoquinol pyridoxine pyridoxine 5'- 2-enyl glutathione 1-phosphate methyl-branched succinate RS15440 cobalt-precorrin-8 quinolinate adenosylcobinamide- ispH CO glyoxylate phosphorylase: WH87_RS08740 containing) diphosphate RS07725 cob(II)yrinate methylase UbiE: ubiE phosphate 2 2,3-bisphosphoglycerate- D-alanine) tetrapeptide 2,3,4-saturated 2-methyladeninyl adenosylcobamide GDP ribazoletransferase: pyridoxamine diphosphate alpha-D-glucose glgP a,c-diamide synthase: preQ dependent fatty acyl-CoA RS15195 biosynthesis from adenosylcobinamide-GDP carboxylating WH87_RS06565 reductase: 1 menaquinol-7 : phosphoglycerate phosphate-specific D-glucopyranose WH87_RS16100 pyridoxal kinase: ispH α nicotinate- WH87_RS13630 IPP tRNA mutase: phosphoglucomutase: -D- 2-methyladenine WH87_RS13630 nucleotide guanosine(34) hydroxylamine WH87_RS08355 WH87_RS11895 glucopyranose a [ribosomal D-glucopyranose a 1-acyl-2- N-succinyl- a [lipoyl-carrier RS06155 cobyrinate menaquinol-6 biosynthesis adenosylcobalamin 5'-phosphate a sulfurated ADP-α-D-glucose menadione NADH H + 5'-deoxyadenosine diphosphorylase: 1-phosphate protein S12] 6-phosphate arachidonoyl- L,L-2,6- asp O-ureido-L- L-threo-3-phenylserine L-allo-threonine protein]-N 6 -[(R) thr ser a tRNA sec RS07700 nicotinate-nucleotide-- pyridoxine pyridoxamine transglycosylase 2-phospho- D-glucopyranose nadC [sulfur carrier] L-aspartate 89 sn-glycerol diaminopimelate homoserine -dihydrolipoyl]- NgcE dimethylbenzimidazole 5'-phosphate 5'-phosphate Tgt: tgt D-glycerate 6-phosphate threonine demethylmenaquinol-6 a 7-aminomethyl-7- alpha-D-glucose 3-phosphate CTP L-lysine dihydrolipoyl phosphoribosyltransferase: NaMN trehalose-6- NADH-quinone 5'-methylthioadenosine/ ammonia- bifunctional 34 phosphopyruvate phosphate-specific cobT deazaguanosine D-xylose 30S ribosomal succinyl- argininosuccinate low-specificity low-specificity dehydrogenase: lyase, serine- cob(II)yrinate pyridoxal 5'- pyridoxal 5'- DMAPP ammonium hydratase: phosphoglucomutase: phosphate oxidoreductase: nuoN S-adenosylhomocysteine RS15385 nicotinate-nucleotide demethylmenaquinone in tRNA degradation I protein S12 phosphatidate diaminopimelate synthase: L-threonine L-threonine WH87_RS01330 biosynthetic: adenosylcobalamin phosphate phosphate WH87_RS08875 WH87_RS11895 synthase: WH87_RS07165 nuoK nucleosidase: -tRNA a,c-diamide adenylyltransferase: methyltransferase/2- tRNA preQ1(34) S- cytidylyltransferase: desuccinylase: WH87_RS18200 aldolase: ltaE aldolase: ltaE RS11930 2-methyladenine synthase: synthase: methylthiotransferase WH87_RS13145 WH87_RS07180 nuoI WH87_RS07815 dihydrolipoyl ilvA ligase: RS07720 WH87_RS17895 methoxy-6-polyprenyl- adenosylmethionine phosphopyruvate D-xylose WH87_RS03705 dapE adenosylcobinamide- ribotide phosphate WH87_RS03765 WH87_RS03765 pyridoxal D-glucopyranose RimO: rimO nuoH WH87_RS07195 dehydrogenase: 2-oxobutanoate serS 1,4-benzoquinol ribosyltransferase- hydratase: xylose a [lipoyl-carrier GDP nicotinate adenine folate transformations III (E. coli) Tetrapyrrole Biosynthesis 6-phosphate nuoE WH87_RS07210 lpdA methylase UbiE: ubiE pyridoxamine pyridoxamine WH87_RS03220 isomerase: α,α-trehalose 6 isomerase QueA: queA 5-deoxy-D-ribose a CDP-1-acyl- canavaninosuccinate benzaldehyde gly acetaldehyde gly protein]-N -[(R FlhA dinucleotide 5'-phosphate 5'-phosphate pyridoxal kinase: a [ribosomal WH87_RS07215 menaquinol-6 34 xylA an unsulfurated ADP 6-phosphate adenine L,L- succinate )-lipoyl]-L-lysine an L-seryl- adeninyl adenosylcobamide biosynthesis an epoxyqueuosine phosphoenol 5'-deoxyadenosine protein S12]-3- 2-arachidonoyl- adenosylcobinamide- NAD+ synthase: NAD+ synthase: a tetrahydrofolate oxidase: pdxH oxidase: pdxH WH87_RS13630 superpathway of heme b D-xylulose met sec RS11065 from adenosylcobinamide-GDP in tRNA pyruvate [sulfur carrier] glycerol diaminopimelate [tRNA ] RS10905 GDP WH87_RS06500 WH87_RS06500 biosynthesis from glutamate superpathway of heme b methylsulfanyl- ribazoletransferase: biosynthesis from glycine tRNA pyruvate : L-aspartate 89 NAD + menadiol WH87_RS06565 NAD + dihydrofolate reductase: methionine PLP epoxyqueuosine(34) kinase: pyk xylB adenine glu RS07655 WH87_RS16165 synthase: metH reductase QueG: queG glutamate-- gly D-xylulose RS11175 Coα-[α-(2- [+ 2 isozymes] a queuosine 34 pyruvate benzimidazolyl adenosylcobamide tRNA ligase: 5-aminolevulinate 5-phosphate a 5,10- a 2-thiouridine 34 quinoxaline-2- sn-glycero-3- 4-methyl-5-(2- a peptide with (3R,5S)-3- nicotinate-nucleotide-- 37 oxaloacetate N-methyl-L- RS07625 methyladenin-9-yl)]-Co in tRNA aryl-carrier protein 2-oxoglutarate phytanoyl-CoA phospho-N- DMAPP an phosphooxyethyl) γ-L-glutamyl-(S)- gly an N-terminal hydroxy-1- L-canavanine dimethylbenzimidazole β biosynthesis from adenosylcobinamide-GDP WH87_RS03665 synthase: hemA methylenetetrahydrofolate in tRNA carboxyl adenylate HMP-PP -adenosylcobamide in tRNA thiazole 2-aminobutanoate citrate synthase: tryptophan phosphoribosyltransferase: thiamine diphosphate serine glutamate-- 5-aminolevulinate (arachidonoyl) L-alanine pyrroline-5- 5'-phosphate a (6S)-5-formyltetrahydrofolate bis(guanylyl molybdopterin) lipoprotein posttranslational modification WH87_RS07295 biosynthesis III benzimidazole a 7,8-dihydrofolate hydroxymethyltransferase:a 5-methyltetrahydrofolate tRNA ligase: ethanolamine carboxylatepyrroline-5- UgpC cobT cofactor sulfurylation tRNA uridine-5- phytanoyl-CoA RS00195 (Staphylococcus) WH87_RS05545 glycine cleavage system WH87_RS06495 porphobilinogen acyl carrier tRNA (adenosine(37)-N6) thiamine glutathione citrate synthase/ N-methyl-L- carboxylate arginase: 2-(2-carboxy-4- 5-formyltetrahydrofolate an L-glutamyl- a [prolipoprotein]- carboxymethylaminomethyl(34) dioxygenase: aminopeptidase adenine ribotide nicotinate-nucleotide-- aminomethyltransferase synthase: hemB protein: glycerophosphodiester -dimethylallyltransferase phosphate synthase: methylcitrate tryptophan reductase: rocF RS10790 α α methylthiazol-5- cyclo-ligase: [tRNA Glu ] L-cysteine synthesis enzyme MnmG: mnmG WH87_RS14315 N: pepN adenosylcobinamide- phosphate Co -[ -(2- HMP-PP dimethylbenzimidazole GcvT: gcvT cys WH87_RS05970 phosphodiesterase: MiaA: miaA synthase: gshB synthase: oxidase: solA WH87_RS12550 yl)ethyl phosphate bifunctional WH87_RS17775 prolipoprotein tRNA uridine-5- phytanoyl-CoA GDP methyladenin-7-yl)]-Co phosphoribosyltransferase: thymidylate synthase: [+ 3 isozymes] porphobilinogen WH87_RS05735 WH87_RS02010 WH87_RS07300 Hyp β methylenetetrahydrofolate5-formyltetrahydrofolate diacylglyceryl carboxymethylaminomethyl(34) dioxygenase: 1,2- -adenosylcobamide cobT WH87_RS10205 cysteine N 6 -(3-methylbut- urea RS12065 RS07600 thiamine benzimidazole dehydrogenase/ cyclo-ligase: transferase: a quinoxaline-2- dihydroxypropane- L-canaline adenosylcobinamide- methylenetetrahydrofolate desulfurase: hydroxymethylbilane Nucleoside and Nucleotide Degradation synthesis GTPase MnmE: mnmE WH87_RS03875 2-en-1-yl)- ophthalmate formaldehyde ala a peptide phosphate thymidylate synthase: methenyltetrahydrofolateWH87_RS01960 WH87_RS12565 carboxyl-[aryl- 1,2,3-tricarboxylate trp adenosylcobinamide- ribotide (S)-4-amino-5- synthase: hemC AMP sn-glycerol 37 thiamine GDP reductase [NAD(P)H]: metF sufS anandamide adenosine RS10690 synthase: GDP phosphate WH87_RS16180 cyclohydrolase FolD: folD an [L-cysteine oxopentanoate a [prolipoprotein]- carrier protein] ribazoletransferase: superpathway of purine deoxyribonucleosides degradation 3-phosphate in tRNA phosphate WH87_RS02010 a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate desulfurase]-S- preuroporphyrinogen S-1,2-diacyl-sn- guanosine a 7,8-dihydrofolate a 5-aminomethyl-2- 2-hydroxyphytanoyl- succinate superpathway of pyrimidine inosine 5'- 34 WH87_RS06565 thiouridine in tRNA CoA RS08055 adenosylcobinamide- sulfanyl-L-cysteine glyceryl-L-cysteine deoxyribonucleosides degradation nucleotides RS15230 bifunctional bis(guanylyl uroporphyrinogen- phosphate Coα-[α-(adenin-9-yl)]- thiamine GDP cysteine degradation III molybdopterin biosynthesis methylenetetrahydrofolate molybdopterin) III synthase: signal 2'-deoxyguanosine 2'-deoxycytidine degradation Coβ-adenosylcobamide phosphate ribazoletransferase: desulfurase: 5-aminolevulinate 3-phenyl-2- a [bis(guanylyl a 2'- a cis-delta19- CTP dehydrogenase/ cofactor WH87_RS18050 peptidase D-glycerate CcmE WH87_RS06565 sufS 2'-deoxyadenosine GMP cob(II)inamide tyr molybdopterin) cofactor cys deoxyribonucleoside a PII protein a RNA-DNA hybrid 37-methoxy-38- glu ala a protein 5'-phosphate dipyrromethane methenyltetrahydrofolate IMP ATP oxopropanoate ATP [DNA] 2'-deoxycytidine a [bis(guanylyl II: lspA nucleoside chaperone]-L-cysteine a tRNA precursor 5'-triphosphate UTP glyoxylate/ cofactor biosynthesis cyclohydrolase FolD: folD porphobilinogen uroporphyrinogen-III IMP 5'-nucleotidase: methyl-C57:1-[acp]cyclopropane ATP- RS12165 Coα-[α- ATP molybdopterin) deaminase: CTP 5'-triphosphate RS10625 GTP synthase: hemB an (S-diacyl-sn- purine-nucleoside dehydrogenase: WH87_RS13195 fatty acyl hydroxypyruvate dependent an apo-[hydroxymethylbilane 10 [bis-MGD cofactor cofactor a lipoprotein WH87_RS17715 ribonuclease HII: deaminase: NAD salvage pathway I (PNC VI cycle) (benzimidazolyl)]-Co cys an N -formyltetrahydrofolate uroporphyrinogen phosphorylase: thymidine 5'/3'-nucleotidase aspartate/ DNA polymerase reductase A: glutamate-- α α thiamine β chaperone]-S- glyceryl)-L-cysteinyl- signal peptide guaB cob(I)yrinic acid a,c-diamide cysteine [protein-PII] WH87_RS00830 phospholipid WH87_RS16890 protease Co -[ -(adenin-7-yl)]- -adenosylcobamide molybdopterin- synthase]-L-cysteine chaperone]- porphobilinogen decarboxylase: cytidine tyrosine/aromatic CCA tRNA III subunit chi: WH87_RS11495 GTP 3',8- [apolipoprotein] deoD thymidine XMP SurE: surE adenosyltransferase: desulfurase: uridylyltransferase: synthase: cysteine ligase: subunit RS10550 Coβ-adenosylcobamide 5'-phosphate cysteine synthase bis-MGD sulfanyl-L-cysteine WH87_RS18585 deaminase: aminotransferase: : [+ 2 isozymes] dCTP + thiamine cyclase guanosine WH87_RS05910 WH87_RS08615 D-glycerate WH87_RS14310 NAD apolipoprotein N- purine-nucleoside phosphorylase: WH87_RS14755 sufS WH87_RS08560 deaminase: dcd HslV: hslV RS12205 diphosphokinase: desulfurase: adenylyltransferase MoaA: moaA a [hydroxymethylbilane hydroxymethylbilane WH87_RS11370 WH87_RS17335 WH87_RS12765 a cis-methoxy- dehydrogenase: RS02405 coproporphyrinogen III acyltransferase: lnt purine-nucleoside phosphorylase: deoA 5'-nucleotidase: cob(I)yrinic acid a,c-diamide [+ 8 isozymes] a peptide sufS MoeB: moeB (8S)-3',8-cyclo-7,8- synthase] ES intermediate synthase: hemC 2'-deoxyinosine purine-nucleoside UTP WH87_RS01770 2 WH87_RS11375 WH87_RS13195 a [bis(guanylyl a nucleoside 5'- C59-meroacyl-[acp] WH87_RS09830 an [L-cysteine a carboxy-adenylated thiamine diphosphate an N-acyl-(S-diacyl- phosphorylase: adenosyltransferase: cobO 3-(4- DNA γ-L-glutamyl- NAD+ synthase: Coα-[α- dihydroguanosine oxygen-dependent a peptide 2'-deoxyuridine thymine phosphorylase: a tRNA a uridylylated monophosphate hydroxypyruvate thiamine [small subunit of hydroxymethylbilane biosynthesis I (E. coli) sulfo-bis(guanylyl preuroporphyrinogen sn-glyceryl)-L- deoD 5'/3'-nucleotidase hydroxyphenyl) ala molybdopterin) D-alanine (benzimidazolyl)]-Co desulfurase]-S- 5'-triphosphate coproporphyrinogen deoD phe containing a [DNA] PII protein WH87_RS06500NAD+ synthase: diphosphate synthase: hemC molybdopterin) cysteinyl-[lipoprotein] SurE: surE cofactor chaperone]- RS10510 β sulfanyl-L-cysteine molybdopterin synthase] cyclic pyranopterin 2-[(2R,5Z)- purine-nucleoside purine-nucleoside adenosylcobinamide pyruvate 3' CCA end RS16010 -adenosylcobamide cofactor uroporphyrinogen- oxidase: hemF purine-nucleoside triphosphate S-sulfanyl-L-cysteine WH87_RS06500 monophosphate a [hydroxymethylbilane 2-carboxy-4- phosphorylase: phosphorylase: SugE III synthase: xanthosine phosphorylase: nicotinate adenine dinucleotide NMN synthase synthase] ES intermediate methylthiazol-5(2H protoporphyrinogen IX deoD WH87_RS11375 3 WH87_RS18050 WH87_RS11375 MoaC: moaC )-ylidene]ethyl purine-nucleoside hydroxymethylbilane HMP-PP periplasmic disulfide bond formation a thiocarboxylated phosphate uroporphyrinogen-III protoporphyrinogen purine-nucleoside 32 an [L-cysteine a 2'- a 2'- a 3-(acyloxy) a [phospholipid]- dCTP a (1->4)- nicotinate-nucleotide S-adenosyl-L-methionine salvage II cyclic pyranopterin synthase: hemC phosphorylase: guanine cob(II)alamin a cytosine an acyl-[acyl- RNA D-glycerate a dipeptide RS12630 [small subunit of oxidase HemJ: hemJ α phosphorylase: desulfurase]-S- deoxyribonucleoside deoxyribonucleoside acyl group of α-D-glucan RS10455 adenylyltransferase: two reduced WH87_RS11375 uracil 2-deoxy- -D- ATP in tRNA carrier protein] [DNA] [DNA] palmitoleate 2'-deoxycytidine molybdopterin synthase] phosphate a [hydroxymethylbilane folate polyglutamylation uroporphyrinogen a [DsbB protein] a [DsbA protein] sulfanyl-L-cysteine 5'-triphosphate 5'-triphosphate bacterial toxin cyclopropane D-glycerate membrane 1,4-alpha- RS10465 WH87_RS17895 thiamine an electron- cysteine residues ribose 1-phosphate deoD synthase] ES intermediate decarboxylase: protoporphyrin IX with reduced L- carrying a dehydrogenase: dipeptidase: 5'-triphosphate glucan SAH 4 phosphate transfer quinone 2-deoxy-α-D- guanine fatty acyl cysteine residues disulfide bond in a protein phosphopentomutase: purine-nucleoside deaminase: hydroxymethylbilane a tetrahydrofolate WH87_RS18585 tRNA 2- phosphate RNA-directed DNA polymerase ribonuclease PH: phospholipid WH87_RS09830 WH87_RS15310 branching NaMN nicotinamide adenosylhomocysteinase: synthase: ribose 1-phosphate WH87_RS11400 phosphorylase: deaminase: guaD cob(I)yrinic acid a,c-diamide acyloxyacyl WH87_RS16890 synthase: hemC ferrochelatase: thiocytidine(32) acyltransferase DNA polymerase: III subunit chi: WH87_RS08465 synthase: glyoxylate/ membrane protein RS12825 WH87_RS10020 WH87_RS02010 coproporphyrinogen III phosphopentomutase: WH87_RS11375 adenosyltransferase: cobO hydrolase: thiamine diphosphate WH87_RS02940 2-deoxy-D-ribose xanthine synthetase PlsX: plsX WH87_RS14220 WH87_RS05910 WH87_RS08560 hydroxypyruvate dipeptidase: dCTP GlgB: glgB UgpC L-homocysteine molybdopterin a holo-[hydroxymethylbilane serine WH87_RS11400 cob(I)yrinic acid a,c-diamide WH87_RS19215 a [phospholipid]-8- a (1,6)-α-D- RS02350 bifunctional biosynthesis II (Bacillus) molybdenum bifunctional 5-phosphate xanthine TtcA: ttcA deaminase: dcd thiamine oxygen-dependent adenosyltransferase: [+ 2 isozymes] [+ 8 isozymes] (2-hexylcyclopropyl) reductase A: WH87_RS07805 glucosyl-(1,4) nicotinate nicotinamidase/ cofactor biosynthesis synthase] hydroxymethyltransferase: folylpolyglutamate protoheme 2-deoxy-D-ribose xanthine a nucleoside dUTP 2-(2-carboxy-4- coproporphyrinogen a 3-hydroxyacyl RNA WH87_RS11495 a proteinogenic α pyrazinamidase: pncA 5-methyltetrahydropteroyltriglutamate- phosphate 10 WH87_RS05545 WH87_RS14755 octanoate - -glucan phosphoribosyltransferase: an N - synthase/ 5-phosphate xanthine dehydrogenase 32 an [L-cysteine diphosphate methylthiazol-5- oxidase: hemF deoxyribose- a 2-thiocytosine an acyl phosphate group of a fatty acid amino acid RS12865 pncB - homocysteine S- HMP-PP molybdopterin dihydrofolate dehydrogenase accessory protein desulfurase]- acyl-carrier protein hydroxypyruvate yl)ethyl phosphate formyltetrahydrofolate phosphate in tRNA [DNA] [DNA] bacterial toxin nicotinate methyltransferase: metE molybdate a 5,10- synthase: deoxyribose- adenosylcobalamin protoporphyrinogen IX aldolase: accessory protein XdhC: xdhC L-cysteine RS17200 methionine synthase: metH glutathione bifunctional methylenetetrahydrofolate triphosphate UgpC thiamine tetrahydrofolate salvage from WH87_RS09370 phosphate deoC XdhC: xdhC [+ 2 isozymes] biosynthesis thiamine folylpolyglutamate cytidylyl phosphate 5,10-methenyltetrahydrofolate bifunctional protoporphyrinogen aldolase: deoC [+ 2 isozymes] met diphosphate synthase/ urate molybdenum synthase: molybdopterin folylpolyglutamate oxidase HemJ: hemJ D-glyceraldehyde RS12970 flavin salvage thioredoxin a 5,10- dihydrofolate a tetrahydrofolate acetaldehyde urate cofactor sulfurylation cys glu adenine synthase/ DsbA family 3-phosphate UDP-N-acetyl-α-D-muramoyl- di-trans,octa-cis a [DNA]-3'- a CDP- a supercoiled cytidine an unstable pathway methionine WH87_RS02010 molybdate synthase: acetaldehyde D-glyceraldehyde 3-phosphate di-trans,octa-cis- UDP-α-D-glucose 2-methylbutanoate sn-glycerol canavaninosuccinate urea-1-carboxylate D-glycerate cytidylyl molybdenum dinucleotide methenyltetrahydrofolate protoporphyrin IX oxidoreductase: L-alanyl-γ-D-glutamyl-L- -undecaprenyl met RecA filament- adenosyltransferase: bifunctional WH87_RS09370 dihydrofolate undecaprenyl phosphate hydroxyl 3-phosphate diacylglycerol duplex DNA nucleoside RS10145 RS01075 riboflavin cofactor (trioxo) methylenetetrahydrofolate synthase: WH87_RS02135 lysyl-D-alanyl-D-alanine phosphate UvrD-helicase glyoxylate/ DNA complex an oxidized 10 a [DsbB protein] a [DsbA protein] bifunctional deaminase: DNA WH87_RS09215 thiamine an N - an intra- bifunctional glutamate-- molybdopterin dehydrogenase/ WH87_RS09370 ferrochelatase: an electron- carrying a with reduced L- domain-containing hydroxypyruvate repair thioredoxin phosphate formyltetrahydrofolate acetate- exodeoxyribonuclease argininosuccinate allophanate glutamate N- WH87_RS17715 riboflavin kinase/ an [MCD cofactor cysteine ligase: molybdotransferase methenyltetrahydrofolate WH87_RS02940 transfer quinol protein disulfide phospho-N- protein: reductase A: protein SAM a 5,10- disulfide bond cysteine residues acetyl-CoA purine ribonucleosides degradation undecaprenyl- -CoA III: WH87_RS18515 lyase: argH hydrolase subunit acetyltransferase/ cytidine FAD synthetase: chaperone]-MCD WH87_RS14310 MoeA: cyclohydrolase FolD: folD glutathione- acetylmuramoyl- WH87_RS16215 WH87_RS11495 10 methylenetetrahydrofolate acetyl-CoA phosphate glucose ligase: acs 1: WH87_RS04175 amino-acid RecO: WH87_RS17515 WH87_RS03155 an N - glutaredoxin protoheme UTP and CTP dephosphorylation I exodeoxyribonuclease argininosuccinate [+ 4 isozymes] deaminase: thioredoxin- cysteine lipoate biosynthesis pentapeptide- : D-glycerate acetyltransferase a stabilizedrecO MscL RS00980 FMN γ-L-glutamyl- formyltetrahydrofolate redox reactions III: xth lyase: argH a single WH87_RS11370 disulfide desulfurase: transferase: WH87_RS13550 dehydrogenase: ArgJ: argJ and incorporation I thiamine MoO - adenosine (2S)-2- stranded DNA RecA filament- L-cysteine 2 phosphoribosylglycinamide NAD 6 37 UTP WH87_RS16315 CMP 1-(3-sn- WH87_RS09830 N-acetyl-L- uridine bifunctional reductase: sufS glutathione Pentose Phosphate Pathways N -L-threonylcarbamoyladenosine ammonium CO DNA complex diphosphate molybdopterin formyltransferase: phosphorylation and methylbutanoyl- diphosphate a 2'- phosphatidyl) 2 trxB a [cytidylyl molybdenum glutathione -modified tRNA biosynthesis α-D-glucopyranosyl- AMP a [DNA]-3'- hydroxypyruvate methionine riboflavin kinase/ an octanoyl-[acp] cofactor WH87_RS03100 menaquinol-9 biosynthesis CTP synthase: UMP CoA deoxyribonucleoside -sn-glycerol L-canavanine fumarate cofactor chaperone]- synthase: transhydrogenation pseudouridine undecaprenyl-diphospho-N- hydroxyl FAD synthetase: lipoyl(octanoyl) pentose phosphate WH87_RS03200 UMP diphosphoundecaprenol 5'-monophosphate 3-phosphate RS02265 cytidylyl molybdenum gshB NAD + a reduced degradation acetylmuramoyl-L-alanyl-γ-D- WH87_RS17515 transferase a tetrahydrofolate pathway (oxidative branch) I thr RS16850 a reduced cofactor (sulfo-dioxo) thiamine demethylmenaquinol-9 glutaredoxin UDP glutamyl-L-lysyl- D-alanyl-D-alanine LipB: lipB glutathione NAD kinase: threonylcarbamoyl- CTP FAD thioredoxin a [lipoyl-carrier protein] diphosphate pseudouridine NADP menaquinol-8 biosynthesis acyl carrier WH87_RS08300 bifunctional D-glucopyranose 6-phosphate AMP synthase: xanthosine adenosine inosine guanosine N 6 -octanoyl-L-lysine salvage III glutaredoxin pseudouridine + demethylmenaquinone WH87_RS00610 UDP-N-acetyl-α-D- (1S,2R)-1- 6-O-trans- a (1->4)- biosynthesis protein activation NADP 3: grxC glucose-6-phosphate (L-threonylcarbamoyl) kinase: (2R,3S)-3- an L-aspartyl- hydrogen lipoyl thiamine methyltransferase/2- di-trans,octa-cis- γ 3-methylbutanoate an alkylated DNA a peptide with a A(H2) carbonic acid α demethylmenaquinol-8 dehydrogenase: zwf adenylate UMP muramoyl-L-alanyl- -D- DL-allothreonine ser C-(indol-3- isopropylmalate Asn peroxide methoxy-mycolyl- -D-glucan RS02240 thiamine a protein with WH87_RS15090 undecaprenyl phosphate leader sequence [tRNA ] NAD + synthase: lipA an apo acyl- methoxy-6-polyprenyl- CDP glutamyl-L-lysyl-D-alanine yl)glycerol 3-isopropylmalate trehalose 6- 1,4-alpha- RS02270 bifunctional reduced L- glucose-6-phosphate tRNA (adenosine(37)-N6)- pseudouridine purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside Asp-tRNA(Asn) a [lipoyl-carrier diphosphokinase: carrier protein 1,4-benzoquinol 5'-nucleotidase: 3-phosphate dehydratase phosphate glucan NAD kinase: demethylmenaquinone holo-ACP cysteine residues dehydrogenase: zwf threonylcarbamoyltransferase 5'-phosphate phosphorylase: phosphorylase: phosphorylase: phosphorylase: acetate- /Glu-tRNA(Gln) catalase/ carbonic trehalose- protein]-N 6 -[(R)- WH87_RS01770 methylase UbiE: ubiE WH87_RS13195 DNA-3- large subunit: leuC branching WH87_RS08300 methyltransferase/2- thiamine synthase: 6-phospho D-glucono-1,5-lactone deoD deoD phospho-N- serine amidotransferase: NADPH menaquinol-9 complex dimerization pseudouridine- 5'/3'- deoD deoD -CoA tryptophan methyladenine peroxidase anhydrase: phosphatase: protein NADP + dihydrolipoyl]-L-lysine methoxy-6-polyprenyl- diphosphate WH87_RS05640 Fatty Acid and Lipid Biosynthesis acetylmuramoyl- hydroxymethyltransferase: 3-isopropylmalate gatC gatA gatB a holo acyl- subunit type 1 TsaB: tsaB 5'-phosphate CMP purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside ligase: acs synthase: trpB glycosylase: HPI: katG WH87_RS18265 otsB GlgB: glgB RS07130 1,4-benzoquinol 6-phosphogluconolactonase: nucleotidase pentapeptide- WH87_RS05545 dehydratase an L-asparaginyl- trehalose- carrier protein [+ 2 isozymes] glycosidase: SurE: surE phosphorylase: phosphorylase: phosphorylase: phosphorylase: WH87_RS09355 WH87_RS11220 Asn trans-methoxy- RS16765 pgl 6 5'-nucleotidase: small subunit: leuD [tRNA ] a GlgE-glycogen methylase UbiE: ubiE an N -L- WH87_RS11375 WH87_RS11375 WH87_RS11375 WH87_RS11375 transferase: palmitate biosynthesis (type II fatty acid synthase) WH87_RS15095 WH87_RS13195 3-methylbutanoyl- (2S)-2- mono-mycolate menaquinol-8 fatty acid elongation -- saturated threonylcarbamoyladenine 37 uridine WH87_RS16315 A H O CO H O D-gluconate 6-phosphate diphosphate D-glyceraldehyde a DNA containing isopropylmalate 2 2 2 uracil 5'/3'- AMP CoA acetaldehyde an alkylated a leader sequence a peptide in tRNA α-D-ribose- gly 3-phosphate trp an apurinic/ nucleotidase nucleobase RS05480 an acetoacetyl-[acp] decarboxylating 6- 1-phosphate undecaprenyl-diphospho-N UMP apyrimidinic site an acetoacetyl-[acp] SurE: surE γ phosphogluconate pyrimidine deoxyribonucleotides -acetylmuramoyl-L-alanyl- - RS09910 3-oxoacyl-[acyl- thymine degradation phosphopentomutase: superpathway of L- Amino Acid Biosynthesis dehydrogenase: gnd cytidine dephosphorylation D-glutamyl-L-lysyl- D-alanine L-histidine biosynthesis L-arginine biosynthesis II (acetyl cycle) L-alanine L-glutamate carrier-protein] WH87_RS11400 isoleucine biosynthesis I L-tryptophan biosynthesis NADP-dependent N-end rule pathway I (prokaryotic) adenosine nucleoside triphosphate biosynthesis III biosynthesis III reductase: fabG thymine D-ribose 5- phosphogluconate nucleotides pyrophosphohydrolase: UDP-N-acetyl- undecaprenyldiphospho- 10 an N-formyl-L- an N-acyl-D- a double a glucosylated RS09570 leucyl/phenylalanyl- phosphate an L-methionyl- an N - carbamoyl (S)-2- an L-glutamyl- D-glucopyranose oxaloacetate PRPP a (3R)-3- dehydrogenase: gndA degradation III mazG α-D-glucosamine N-acetylmuramoyl-L- methionylaminoacyl- L-ornithine glu glucosamine glycogenin N-acetylglutamyl-phosphate tRNA--protein [initiator tRNA Met ] formyltetrahydrofolate ATP aminobutanoate [tRNA Gln ] stranded DNA GTP cys chorismate gln 2-oxoglutarate hydroxybutanoyl-[acp] a 3-oxoacyl-[acp] dCTP dCMP γ tRNA phosphate 6-phosphate glucose 1- DNA 1,4-alpha- aspartate/ glutamate transferase: 5,6-dihydrothymine alanyl- -D-glutamyl-meso 4'-phosphopantetheine putative N- Asp-tRNA(Asn) RS09730 ATP cysteine D-ribulose 5-phosphate S-methyl-5'-thioadenosine dehydrogenase: glucan tyrosine/aromatic 3-hydroxyacyl- a [protein] AMP -2,6-diaminopimeloyl- acetylmannosamine- /Glu-tRNA(Gln) topoisomerase diguanylate phosphoribosyltransferase: synthase: an N-terminal WH87_RS07535 degradation IV branching aminotransferase: superpathway of branched chain amino acid biosynthesis desulfurase: N-terminal L- dihydropyrimidinase: D-alanyl-D-alanine methionyl-tRNA peptide glutamate-- WH87_RS17120 (ATP- cyclase: anthranilate synthase gltB gltD ACP dehydratase arginyl-[protein] dUTP diphosphatase: ornithine 6-phosphate amidotransferase: WH87_RS17335 WH87_RS17440 sufS leucyl-L-arginine AMP nucleosidase: S-methyl-5'- hydA pantetheine-phosphate hydrolyzing) protein RS04490 N-acetyl- component I: trpE FabZ: fabZ WH87_RS09640 formyltransferase: deformylase: carbamoyltransferase: cysteine ligase: 2-epimerase: gatC gatA gatB glucose 1- WH87_RS17730 1-(5-phospho- ala glu WH87_RS03230 thioadenosine undecaprenyldiphospho- adenylyltransferase: an L-glutaminyl- subunit B: gyrB GlgB: glgB asp pyruvate gamma-glutamyl- 5'-methylthioadenosine/ 3-(carbamoylamino)- nucleoside triphosphate WH87_RS11540 WH87_RS11545 argF WH87_RS14310 α WH87_RS10490 dehydrogenase: [+ 9 isozymes] β 3-hydroxyacyl- an N-acyl- -D- Gln -D-ribosyl)-ATP thr 3-oxoacyl-[acyl- 2-methylpropanoate muramoylpentapeptide beta-N- coaD [tRNA ] WH87_RS13350 [+ 3 isozymes] c-di-GMP a glycogen RS01390 phosphate [acyl-carrier- NADPH repair (prokaryotes) leucyl/phenylalanyl- adenine S-adenosylhomocysteine pyrophosphohydrolase: mannosamine phosphoribosyl- acetolactate reductase: argC anthranilate PRPP beta-ketoacyl- carrier-protein] acetylglucosaminyltransferase: D-glucono- a negatively : acetylglutamate protein] tRNA--protein nucleosidase: mazG an N-formyl- γ-L-glutamyl-(S)- 6-phosphate ATP synthase: ilvN threonine ACP synthase reductase: fabG dUTP dUMP murG a L-methionylaminoacyl- 1,5-lactone supercoiled DNA WH87_RS14230 kinase: argB dehydratase NADPH transferase: WH87_RS07815 L-methionyl- a tetrahydrofolate formate L-citrulline RS18315 diphosphatase: ammonia- a [protein] tRNA 3'-dephospho-CoA 2-aminobutanoate WH87_RS16110 gln N-acetyl-L-glutamate II: fabF WH87_RS07535 [initiator tRNA met ] lyase, glu N-acetyl-L-glutamate anthranilate FabA: fabA an N-terminal MTR lipid II (meso WH87_RS02955 5-semialdehyde [+ 2 isozymes] N-terminal L- (R)-3-amino-2- UDP L-aspartyl- biosynthetic: bifunctional phosphoribosyltransferase: trpD a 2,3,4-saturated a (3R)-3-hydroxyacyl- L-lysyl-[protein] diaminopimelate containing) 1-(5-phospho-β- (S)-2-acetolactate leucyl-L-lysine methylpropanoate 5-hydroxy-CTP 5-hydroxy-CMP RS14620 4-phosphate ilvA glutamate N- glutamine- N-acetylornithine a (2E)-but-2-enoyl-[acp] fatty acyl-[acp] [acyl-carrier protein]3-hydroxyacyl- D-ribosyl)-AMP ketol-acid hydrolyzing aminotransferase: acetyltransferase/ bifunctional N-(5-phosphoribosyl)-anthranilate [acyl-carrier- 6 aspartate- (2Z)-2-aminobut- an N -L- an N-terminal α a [protein] N- a ribonucleoside 1498 an insertion a protein RS18210 phosphoribosyl- reductoisomerase: amino-acid carbamoyl- glutamate N- WH87_RS16695 trans-2-enoyl- protein] an L-arginyl- 7,8-dihydrofolate + an (R)-2- an N -methyl a uracil D-glucopyranose α-amylose semialdehyde 2-enoate (R)-NADPHX a sulfurated threonylcarbamoyladenine 37 3-sulfo-L- NADPH H terminal-formyl- 2',3'-cyclic sequence Arg monoglutamate with incorrect AMP ilvC acetyltransferase phosphate acetyltransferase/ phosphoribosylanthranilate CoA reductase dehydratase bifunctional [sulfur carrier] [tRNA ] halocarboxylate L-amino acid in 16S rRNA dehydrogenase: Fatty Acid and Lipid Degradation in tRNA alanyl-[protein] L-methionine phosphate 16S rRNA glucose 1- element IS30 disulfide bonds 1,4-alpha- cyclohydrolase: (2R)-2,3- ArgJ: argJ synthase small family ADP-dependent C1 Compound Utilization and Assimilation bifunctional 2',3'- : thiol:disulfide WH87_RS18245 amino-acid isomerase: WH87_RS09345 FabA: fabA (uracil(1498)-N(3))- dehydrogenase: glucan hisI dihydroxy-3- subunit: carA protein: fabV NAD(P)H-hydrate Respiration cyclic-nucleotide 2'- WH87_RS19360 interchange CcmB acetyltransferase 1-(2-carboxyphenylamino)-1- 3-hydroxyacyl- dihydrofolate HAD family methyltransferase: WH87_RS13350 branching L-aspartate 4- 1-(5-phospho-β-D-ribosyl)- methylbutanoate L-lysine biosynthesis III dehydratase/ oleate β-oxidation tRNA (N(6)-L- N-methyl-L- peptide phosphodiesterase/ transposase: protein carbamoyl- ArgJ: argJ deoxy-D-ribulose 5-phosphate ACP dehydratase fatty acid β-oxidation I (generic) formaldehyde oxidation arginyltransferase: reductase: hydrolase: protein semialdehyde 5-[(5-phosphoribosylamino) dihydroxy-acid 2-iminobutanoate a butanoyl-[acp] NAD(P)H-hydrate 2-oxoglutarate decarboxylation to succinyl-CoA tryptophan deformylase: 3 WH87_RS14305 glucose 1- DsbG: dsbG UgpC phosphate VII (THF pathway) formaldehyde threonylcarbamoyladenosine(37) WH87_RS05600 WH87_RS13430 WH87_RS08505 3'-nucleotidase: an N - an insertionWH87_RS19370 a protein GlgB: glgB FabZ: fabZ 1498 dehydrogenase: homoserine methylideneamino]imidazole- dehydratase: N-acetyl-L-ornithine indole-3-glycerol phosphate epimerase: oxidation II -C(2))- methylthiotransferase oxidase: solA WH87_RS11545 WH87_RS12455 methyluracil sequence IS30 with correct synthase large asp a [2-oxoglutarate oleate a (3Z)-alk-3- [+ 2 isozymes] [+ 3 isozymes] a ribonucleoside WH87_RS17120 amylopectin dehydrogenase: 4-carboxamide ilvD synthase TrpC: trpC beta-ketoacyl- a 2,3,4-saturated a trans-2-enoyl- WH87_RS07330 (glutathione-dependent) MtaB: mtaB in 16S rRNA with integrated disulfide bonds subunit: carB dehydrogenase enoyl-CoA formaldehyde an N-terminal L- 3'-phosphate D-glucono- RS18280 WH87_RS15040 1-(5-phosphoribosyl)-5- 3-methyl-2- aspartate kinase: ACP synthase fatty acyl-[acp] [acyl-carrier protein] (S)-NADPHX long-chain fatty transposon 6 formaldehyde Arg an N-terminal L- L-ornithine II: fabF E2 protein] N 6 a tRNA arginiyl-3-sulfo- 5,6,7,8- an (S)-2- formaldehyde formate 1,5-lactone [(5- phosphoribosylamino) oxobutanoate carbamoyl phosphate WH87_RS14230 (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate 2-oxoglutarate acid--CoA ligase: a 2-methylsulfanyl-N -L- + an L-amino acid homoserine 2-oxobutanoate -lipoyl-L-lysine NADP a halide anion methionyl-[protein] methylideneamino]imidazole-4- trans-2-enoyl- bifunctional 37 5'-deoxyadenosine an unsulfurated L-alanyl-[protein] tetrahydrofolate hydroxycarboxylate RS09060 dehydrogenase: L-aspartyl- [+ 2 isozymes] dehydrogenase WH87_RS02440 a 5,10- threonylcarbamoyladenine met carboxamide isomerase: hisA CoA reductase ADP-dependent 2-oxoglutarate [sulfur carrier] WH87_RS05410 2-isopropylmalate branched-chain acetolactate 4-phosphate tryptophan synthase: E1 component: a (2E)-2- methylenetetrahydrofolate S-(hydroxymethyl) in tRNA a 3-oxohexanoyl-[acp] family NAD(P)H-hydrate dehydrogenase oleoyl-CoA synthase: amino acid synthase: ilvN trpB WH87_RS09355 WH87_RS01345 enoyl-CoA BamD phosphoribulosylformimino- E1 component: bifunctional glutathione RS18075 WH87_RS15955 aminotransferase: aspartate- protein: fabV dehydratase/ a 2,3,4-saturated L-homoserine AICAR-phosphate WH87_RS16110 acyl-CoA methylenetetrahydrofolate 6 ser 3-oxoacyl-[acyl- WH87_RS01345 S-(hydroxymethyl) N -(3-methylbut- an N-terminal 34 a thiocarboxylated a peptide with N-acetyl-D- adenosine a (1->4)- WH87_RS11790 semialdehyde indole NAD(P)H-hydrate fatty acid acyl-CoA a 2,3,4- an L-arginyl- a uridine an (S)-2- a [protein]-L- (S)-4- succinate RS13615 (S)-2-aceto-2- dehydrogenase: long-chain fatty dehydrogenase/ glutathione galactosamine a protein with α dehydrogenase: carrier-protein] epimerase: a sulfurated [sulfur carrier] 2-en-1-yl)- 3-sulfino-L- Arg [SAMP] C- an N-terminal 2',3'-cyclic β -D-glucan (2S)-2- ornithine [+ 2 isozymes]a [2-oxoglutarate a [2-oxoglutarate dehydrogenase: saturated (3R)-3- [tRNA ] in tRNA halocarboxylate -isoaspartate hydroxymandelate semialdehyde a disulfide bond imidazole hydroxybutanoate reductase: fabG WH87_RS02435 acid--CoA ligase: methenyltetrahydrofolate dehydrogenase/ adenosine 37 in tRNA alanyl-[protein] terminal glycine Xaa-L-proline 6-phosphate monophosphate protein-L- mandelate NAD-dependent 1,4-alpha- isopropylmalate carbamoyltransferase: WH87_RS18245 WH87_RS07330 dehydrogenase dehydrogenase WH87_RS02435 a 2,3,4- hydroxyacyl-CoA bifunctional 2',3'- protein- glycerol ketol-acid tryptophan synthase: (2E,9Z)- WH87_RS02440 a 2,3,4-saturated cyclohydrolase FolD: folD class III alcohol isoaspartate O- racemase: succinate- glucan FlgH val argF L-aspartate 4- a (3R)-3- CDP-diacylglycerol CDP-diacylglycerol E2 protein] N 6 E2 protein] N 6 -S- saturated (3S)-3- cyclic-nucleotide 2'- disulfide 3-isopropylmalate trpB WH87_RS09355 dehydrogenase: HAD family WH87_RS00370 branching Pal phosphate reductoisomerase: biosynthesis II biosynthesis I NADPH octadecenoyl-CoA fatty acyl CoA a 5,10- tRNA 2- leucyl N-acetylglucosamine- methyltransferase: semialdehyde reductase RS17760 O-phospho- dehydratase superpathway semialdehyde hydroxyhexanoyl-[acp] -dihydrolipoyl- succinyldihydrolipoyl- hydroxyacyl-CoA tRNA (N6-isopentenyl arginyltransferase: hydrolase: phosphodiesterase/ protein synthase: ilvC methenyltetrahydrofolate WH87_RS07985 thiouridine(34) aminopeptidase: 6-phosphate βWH87_RS04560 mandelate dehydrogenase: RS04345 L-homoserine small subunit: leuD of L-threonine L-lysine L-lysine adenosine(37)-C2)- WH87_RS05600 WH87_RS08505 3'-nucleotidase: a protein L- - a protein withDsbD: dsbD hisF hisH (R)-2,3-dihydroxy- 4-hydroxy- 3-hydroxyacyl- DHAP bifunctional synthase racemase: WH87_RS00390 GlgB: glgB biosynthesis trp DHAP methylthiotransferase WH87_RS05915 deacetylase: nagA WH87_RS12455 isoaspartate reduced L- threonine 3-isopropylmalate tetrahydrodipicolinate ACP dehydratase S-formylglutathione MnmA: mnmA [+ 3 isozymes] 3-methylpentanoate coenzyme A methylenetetrahydrofolate MiaB: miaB α-methyl ester WH87_RS17130 succinate starch synthase: D-erythro-1- dehydratase synthase: FabZ: fabZ (S)-3-hydroxy-(9Z) 3'-AMP (R)-4- cysteine residues oxaloacetate L-phenylalanine a 2,3,4-saturated a 2,3,4-saturated dehydrogenase/ an N-terminal L- AICAR (imidazol-4- dihydroxy-acid uracil degradation 2-oxoglutarate -octadecenoyl-CoA 3-ketoacyl- a peptide with D-galactosamine WH87_RS00965 large subunit: leuC L-citrulline aspartate/ WH87_RS05670 biosynthesis I 3-hydroxyacyl- sn-glycerol sn-glycerol methenyltetrahydrofolate a tRNA Arg arginiyl-3-sulfino- 34 a proteinogenic acetate hydroxymandelate RS13695 dehydratase: (2S,4S)-4- I (reductive) fatty acyl CoA CoA thiolase: 3-oxoacyl-CoA N 6 -(3-methylbut-2-en- a [SAMP] C- a 2-thiouridine an (S)-2- an N-terminal 6-phosphate threonine yl)-glycerol tyrosine/aromatic [acyl-carrier- 3-phosphate 3-phosphate dehydrogenase cyclohydrolase FolD: folD L-alanyl-[protein] a halide anion amino acid UgpC 2-isopropylmaleate ilvD hydroxy-2,3,4,5- WH87_RS02425 5'-deoxyadenosine 1-yl)-2-(methylsulfanyl) an unsulfurated terminal glycine in tRNA hydroxycarboxylate L-proline synthase: 3-phosphate aminotransferase: chorismate uracil protein] E1 component: met argininosuccinate glycerol-3- glycerol-3- 10 37 [sulfur carrier] imidazoleglycerol- (3S)-3-methyl-2- tetrahydrodipicolinate TCA cycle TCA cycle I (prokaryotic) WH87_RS01345 an N - formate adenosine in tRNA WH87_RS01090 3-isopropylmalate synthase: WH87_RS17335 chorismate dehydratase phosphate 1-O- phosphate 1-O- phosphate oxopentanoate 4-hydroxy- 3-oxo-(9Z)- formyltetrahydrofolate WH87_RS18200 asp mutase: FabA: fabA 2-oxoglutarate dehydratase tetrahydrodipicolinate acyltransferase acyltransferase octadecenoyl-CoA dehydratase branched-chain acetyl-CoA formyltetrahydrofolate 34 (12Z,15Z)-9,10- thr small subunit: leuD WH87_RS03075 5,6-dihydrouracil PlsY: plsY PlsY: plsY dehydrogenase a [2-oxoglutarate- a [protein]-S- a uridine an (S)-2- guanosine a cis-delta21-39- RS05285 HisB: hisB amino acid L-arginino-succinate reductase: 3-ketoacyl- a sulfurated coenzyme A an apo [peptidyl- adenosylcobinamide aci-nitroethane L(or D)-O- an unfolded prephenate a (2E)-hex-2-enoyl-[acp] a 1-acyl-sn a 1-acyl-sn complex acetyl-CoA deformylase: purU SAM dehydrogenase sulfanyl-L-cysteine in tRNA 2',3'-cyclic epoxyoctadeca- oxo-40-methyl- a protein RS05220 3-(imidazol-4- 3-isopropylmalate aspartate kinase: WH87_RS08345 CoA thiolase: carrier protein] halocarboxylate phosphoserine protein aminotransferase: [sulfur carrier] 6 12,15-dienoate threonine dihydropyrimidinase: -glycerol 3- -glycerol 3- oxaloacetate dihydrolipoyllysine- E2 protein] N - bifunctional monophosphate C59:1-[acp]cyclopropane ATP-dependent yl)-2-oxopropyl dehydratase WH87_RS11790 argininosuccinate WH87_RS14230 prephenate WH87_RS02425 formate bifunctional 2',3'- epoxide phosphoserine ammonia- (S)-2,3,4,5- hydA trans-2-enoyl- phosphate phosphate residue octanoyl-L-lysine adenosylcobinamide Clp protease: clpX phosphate large subunit: leuC lyase: argH dehydratase: citrate synthase: tRNA 2- HAD family nitronate cyclic-nucleotide 2'- hydrolase: fatty acyl phosphatase chaperonin lyase, tetrahydrodipicolinate CoA reductase 1-acyl-sn-glycerol- 1-acyl-sn-glycerol- succinyltransferase: holo-ACP kinase/ WH87_RS07315 histidinol- argininosuccinate L-aspartyl- WH87_RS11505 WH87_RS07295 (7Z)-hexadecenoyl-CoA thiouridine(34) hydrolase: monooxygenase: phosphodiesterase/ WH87_RS08575 phospholipid SerB: serB GroEL: groL biosynthetic: (2R,3S)-3- ile 3-ureidopropanoate family 3-phosphate 3-phosphate malate/lactate/ odhB lipoyl synthase: adenosylcobinamide- RS07015 phosphate 4-phosphate [+ 2 isozymes] WH87_RS12015 3'-nucleotidase: (12Z,15Z)-9,10- synthase: [+ 2 isozymes] ilvA isopropylmalate lyase: argH 3-phenyl-2- protein: fabV acyl-CoA Carboxylate Degradation synthase: WH87_RS05640 synthase WH87_RS08505 phosphate RS00575 acyltransferase: acyltransferase: ureidoglycolate WH87_RS12455 dihydroxyoctadeca- WH87_RS08560 serine a protein transaminase: 3-isopropylmalate aspartate- oxopropanoate MnmA: mnmA [+ 3 isozymes] guanylyltransferase: a peptide (2Z)-2-aminobut- L-proline WH87_RS09240 WH87_RS09240 dehydrogenase: dehydrogenase: lipA 12,15-dienoate a cis-keto-C60- WH87_RS14845 dehydrogenase: arg L-α-amino-ε- a hexanoyl-[acp] a 1,2-diacyl- a 1,2-diacyl- 3'-GMP 2-enoate semialdehyde aspartate/ WH87_RS08045 WH87_RS02435 pyruvate decarboxylation to acetyl CoA I cobU meroacyl-[acp] biosynthesis I propanoyl CoA D-gluconate a [2-oxoglutarate 3',5'-ADP a holo [peptidyl- acetaldehyde nitrite L-histidinol leuB dehydrogenase: keto-pimelate tyrosine/aromatic sn-glycerol sn-glycerol malate dehydrogenase: mdh (2E,7Z)- 2-hydroxypenta-2,4- an unsulfurated a [protein]- a 2-thiouridine 34 a (2R)-2- adenosyl-cobinamide (from L-glutamate) degradation I degradation 5'-deoxyadenosine met dehydrogenase carrier protein] a halide anion phosphate (2S)-2-isopropyl- superpathway of L-serine WH87_RS18245 diaminopimelate aminotransferase: β-alanine beta-ketoacyl- 3-phosphate 3-phosphate (S)-malate citrate hexadecenoyl-CoA a [pyruvate dienoate degradation [sulfur carrier] L-cysteine in tRNA phosphate RS08635 E2 protein] N 6 hydroxy fatty acid RS14115 3-oxosuccinate and glycine biosynthesis I WH87_RS17335 ACP synthase phosphatidate phosphatidate dehydrogenase histidinol- glu L-aspartate 4- dehydrogenase: propanoyl-CoA (2Z)-2- D-gluconate -lipoyl-L-lysine II: fabF cytidylyltransferase: cytidylyltransferase: E2 protein] N 6 pyruvate hydroxypenta- 2-iminobutanoate phosphatase: glutamate semialdehyde WH87_RS04460 acyl-CoA : 3-phospho-D-glycerate L-arginine phe [+ 2 isozymes] WH87_RS03705 WH87_RS03705 -lipoyl-L-lysine 2,4-dienoate hisN 5-kinase: homoserine meso- pyruvate carboxylase 2-keto-4- WH87_RS13340 phosphoglycerate WH87_RS17885 degradation I a CDP- a CDP- aconitate hydratase (S)-3-hydroxy-(7Z) dihydrolipoyl D-gluconate adenine 2503 an apo-[LYS2 L- an (R)-2- 3-(N-morpholino) guanosine 2251 (9Z,15Z)-12,13- D-ribose 5- γ-L-glutamyl dehydrogenase: diaminopimelate dehydrogenase: subunit beta: pentenoate coenzyme A isobutanoate acetyl-CoA propanoyl-CoA [DNA] heme b CcmA heme b histidinol 4-methyl-2- dehydrogenase: (arginase pathway) a 3-oxooctanoyl-[acp] diacylglycerol diacylglycerol AcnA: acnA -hexadecenoyl-CoA 2-aminoadipyl- epoxy-octadeca- a protein repressor LexA phosphate RS14075 L-cysteine biosynthesis I class II fumarate dehydrogenase: WH87_RS03605 hydratase: 6-phosphate in 23S rRNA halocarboxylate propanesulfonate in 23S rRNA oxopentanoate WH87_RS12845 5-phosphate WH87_RS15040 WH87_RS09945 23S rRNA 9,15-dienoate DNA ribose-5- diaminopimelate hydratase: fumC lpdA (S)-methylmalonyl- WH87_RS06485 carrier-protein] histidinol glutamate-5- arg homoserine 3-oxoacyl-[acyl- pdhA (S)-4-hydroxy- epoxide polymerase transcriptional phosphate 2-oxobutanoate branched-chain phosphoglycerate decarboxylase: lysA CoA (guanosine(2251) endopeptidase La: 2+ 2+ dehydrogenase: carrier-protein] fumarate cis-aconitate dihydrolipoyl 2-oxopentanoate 23S rRNA HAD family FMNH2-dependent acetyl-CoA C- hydrolase: repressor Cd CadA Cd amino acid dehydrogenase: semialdehyde arginase: dehydrogenase: ser methylmalonyl- holo-ACP acetate--CoA -2'-O)- III subunit WH87_RS07285 isomerase hisD reductase: fabG aconitate hydratase 3-oxo-(7Z)- dehydrogenase: (adenine(2503)-C(2) hydrolase: alkanesulfonate acetyltransferase: WH87_RS08575 LexA: lexA acetolactate aminotransferase: WH87_RS01810 dehydrogenase: rocF WH87_RS05410 a [pyruvate CoA synthase: ligase: acs methyltransferase (9Z,15Z)-12,13- epsilon: dnaQ RpiA: rpiA lys biotin-carboxyl carrier cyclopropane AcnA: acnA hexadecenoyl-CoA WH87_RS01330a [pyruvate pyruvate )-methyltransferase WH87_RS08505 monooxygenase: WH87_RS02425 D-ribulose RS14005 synthase: ilvN WH87_RS11790 WH87_RS17890 serine O- a (3R)-3- dehydrogenase epimerase: mce WH87_RS05640 RlmB: rlmB dihydroxyoctadeca- [+ 3 isozymes] cleaved histidinal 3-phosphooxypyruvate L-ornithine protein assembly fatty acid (CFA) dehydrogenase dehydrogenase RlmN: rlmN ssuD 2-O- a 2'- a peptide 5-phosphate WH87_RS16110 L-homoserine acetyltransferase: hydroxyoctanoyl-[acp] 3-ketoacyl- E2 protein] N 6 -S- [+ 3 isozymes] repressor LexA L-glutamate-5- biosynthesis 6 2251 9,15-dienoate ammonia assimilation cycle III E2 protein] N - complex (R)-methylmalonyl- acetate a holo-[LYS2 L- methylguanosine deoxyribonucleoside TolR (S)-2-aceto-2- histidinol leu phosphoserine cysE a [biotin carboxyl- a [phospholipid] cis CoA thiolase: acetyldihydrolipoyl- acetaldehyde isobutanoyl-CoA 3-oxopentanoyl- semialdehyde 3-hydroxyacyl- dihydrolipoyl-L-lysinedihydrolipoamide CoA conversion 3',5'-ADP diphosphate in 23S rRNA 5'-monophosphate hydroxybutanoate dehydrogenase: transaminase: WH87_RS02425 L-lysine a 2-methyladenine 2503 2-aminoadipyl- AMP 3-(N-morpholino) CoA ACP dehydratase carrier protein]-L-lysine -olefinic fatty acid to acetyl-CoA 5'-deoxyadenosine a (2R)-2- sulfite + + WH87_RS01815 O-acetyl-L-serine cyclopropane acetyltransferase: methylmalonyl- met carrier-protein] a halide anion Na RS18170 Na ketol-acid hisD ammonium hydrogen sulfide biotin--[acetyl- in 23S rRNA hydroxy fatty acid propanal FabZ: fabZ fatty acyl (5Z)-tetradecenoyl-CoA WH87_RS03600 CoA acetate reductoisomerase: L-glutamate-5- CoA-carboxylase] succinate D-threo-isocitrate O-phospho- 3-hydroxyacyl- phospholipid mutase: scpA acetate- his O-phospho-L-serine semialdehyde glu glutamine NADP-dependent ilvC (S)-1-pyrroline- ligase: acyl-CoA acetyl-CoA YidD L-homoserine synthetase: cysteine synthase [acyl-carrier- synthase: isocitrate dehydrogenase: -CoA RS14070 (R)-2,3-dihydroxy- 5-carboxylate WH87_RS07155 dehydrogenase: succinyl-CoA lysine within an sn-glycero-3- a [release factor]- an [amino-group carrier (9Z,12Z)-15,16- a uridine 38- phosphoserine bifunctional threonine glutamate WH87_RS11695 A: WH87_RS05125 protein] a [phospholipid]WH87_RS08560 ADP-forming succinate- WH87_RS15555 ligase: acs an N-terminal an L-phenylalanyl- a protein with glutathione isethionate long chain a glycogen 3-methylpentanoate 2-oxoglutarate a [biotin carboxyl- WH87_RS02435 gcv protein H an octanoyl-[acp] phospho-N-(acyl) protein]-C-terminal-γ- epoxyoctadeca- 40 in tRNA pyrroline-5- proline synthase: dehydratase -CoA ligase: sucD sucC acetyl-CoA acetyl-CoA arginyl-[protein] [tRNA Phe ] a disulfide bond L-glutamine hypoxanthine polyphosphate phosphatase SerB: serB synthase: type I glutamate- carrier protein]-N fatty acid containing ethanolamine peptide chain (L-glutamyl)-L-glutamate 9,12-dienoate RluA family polyphosphate glycogen dihydroxy-acid carboxylate dehydrogenase/L- gltB gltD FabA: fabA (2E,5Z)- WH87_RS00965 -ammonia 6 -biotinyl-L-lysine cyclopropane release factor epoxide pseudouridine debranching dehydratase: reductase: glutamate gamma- cys tetradecenoyl-CoA acetylglutamate xanthine kinase 2: ppk2 alanine ser ligase: glnA NADH repair (prokaryotes) lipoyl(octanoyl) FMNH2-dependent hydrolase: protein glycine threonine imidazole leucyl/phenylalanyl- glycerophosphodiester N(5)-glutamine kinase: argB synthase: dehydrogenase: polyphosphate UgpC ilvD racemization WH87_RS12550 semialdehyde a (2E)-oct-2-enoyl-[acp] alkanesulfonate WH87_RS08575 GlgX: glgX HflB synthase: glycerol tRNA--protein transferase glutaredoxin phosphodiesterase: methyltransferase: WH87_RS01760 kinase 2: ppk2 (3S)-3-methyl-2- biosynthesis IV L-ornithine degradation dehydrogenase succinyl-CoA 2-oxoglutarate monooxygenase: an [amino-group carrier (9Z,12Z)-15,16- xdhB xdhA serine WH87_RS01090 phosphate NADH Detoxification transferase: LipB: lipB 3: grxC WH87_RS05735 WH87_RS14245 [+ 3 isozymes] 6,8- long chain a maltodextrin I (L-proline biosynthesis) pro PutA: putA trans-2-enoyl- a [biotin carboxyl- 5 protein]-C-terminal- dihydroxyoctadeca- 38- oxopentanoate hydroxymethyltransferase: ammonium gln ssuD a [release factor]-N a pseudouridine dihydroxypurine polyphosphate ala synthase: CoA reductase carrier-protein dimer]- (3E,5Z)-tetradeca- (S)-3-hydroxy-(5Z) WH87_RS07535 γ-(5-phospho-L- 9,12-dienoate branched-chain thr WH87_RS05545 thr a [glycine-cleavage -methyl-L-glutamine 40 in tRNA alanine hisF hisH 6 a protein with low-specificity glu family N -biotinyl-L-lysine 3,5-dienoyl-CoA -tetradecenoyl-CoA reactive oxygen species degradation complex H protein] an N- glutamyl)-L-glutamate amino acid L-ornithine racemase: arsenate arsenate triclosan acyl-carrier protein GSSG sn-glycerol [+ 6 isozymes] protein: fabV acetyl-CoA acetyl-CoA 8-oxo-(d)GTP detoxification I L-phenylalanyl-L- 6 reduced L- glycolaldehyde RS04385 RS06310 L-threonine ornithine gly acyl-CoA Phe N -octanoyl-L-lysine acylethanolamine sulfite aminotransferase: alr 2-oxoglutarate detoxification detoxification resistance arginyl-[protein] a tRNA cysteine residues 3-phosphate aldolase: ltaE cyclodeaminase: D-ala carboxylase carboxylase thioesterase: WH87_RS11790 an octanoyl-[acp] dehydrogenase (R)-NADHX superoxide III (thioredoxin) II (glutaredoxin) a trans-2- gly WH87_RS15510 carboxyltransferase biotin WH87_RS16550 E1 component: bifunctional 3-oxo-(5Z)- enoyl-[acyl- pro glu subunit beta: carboxylase superoxide arsenate arsenate dGTP GTP ile WH87_RS01345 (3E,5Z)- carrier protein] beta-ketoacyl- WH87_RS09360 subunit: accC ADP-dependent tetradecenoyl-CoA dismutase: arsenate arsenate trans-2- an N-terminal a 3,5,7,9,11,13,15- an [RNA]-3'- a [phospholipid]- 6-O-cis-methoxy- tetradecadienoate an L-phenylalanyl- coenzyme A AsbD acyl- an L-arginyl- O-succinyl-L- an N-acylated- (S)-5-hydroxyisourate 7,8-dihydropterin UgpC ACP synthase a [carboxyl-carrier NAD(P)H-hydrate 3-ketoacyl- enoyl-CoA a protein Arg hepta-oxo- ribonucleoside- mycolyl-trehalose RS13730 WH87_RS06355 reductase reductase L-lysyl-[protein] [tRNA Phe ] carrier protein [tRNA ] homoserine D-amino acid oleate purine II: fabF 6 dehydratase/ CoA thiolase: reductase hexadecanoyl-[PKS-acp] 2',3'- cyclopropane 6-phosphate protein dimer]-N - superoxide (glutaredoxin) (glutaredoxin) 8-oxo-dGTP 8-oxo-GTP aldo/keto guanine NAD(P)H-hydrate WH87_RS02425 family cyclophosphate hydroxyisourate fatty acyl trehalose- [+ 2 isozymes] carboxybiotinyl-L-lysine dismutase: : arsC : arsC reductase: RNA 2',3'-cyclic xanthine deaminase: superpathway of glycolysis and the Entner-Doudoroff pathway epimerase: 8-oxo-dGTP protein: leucyl/phenylalanyl- holo-ACP hydrolase: uraH phospholipid phosphatase: (3Z)-dodec- WH87_RS06960 arsenite arsenite WH87_RS12875 phosphodiesterase: dehydrogenase: guaD a 3-oxodecanoyl-[acp] WH87_RS07330 diphosphatase fabV tRNA--protein synthase: arginyltransferase: O-succinylhomoserine D-aminoacylase: (S)-2-oxo-4- synthase: otsB Nucleoside and Nucleotide Biosynthesis (S)-NADHX 3-enoyl-CoA a 2,3,4-saturated [+ 12 isozymes] thpR xdhB xdhA trehalose- 7,8- RS07000 D-glucopyranose hydrogen WH87_RS05640 WH87_RS05600 sulfhydrylase: metZ WH87_RS10495 9-hydroxy-3,5,7,11,13,15- an [RNA]-3'- MutT: mutT transferase: hydroxy-4-carboxy- WH87_RS08560 cis-methoxy- dihydrolumazine SecD 3-oxoacyl-[acyl- 6-phosphate peroxide fatty acyl-[acp] hexaoxohexadecanoyl- ribunucleoside- a [phospholipid]- 8-hydroxypurine bifunctional 8-oxo-GMP WH87_RS07535 5-ureidoimidazoline mono-mycolate superpathway of pyrimidine carrier-protein] 8-oxo-dGMP [PKS-acp] 2'-phosphate dihydrosterculate superpathway of guanosine inosine-5'-phosphate biosynthesis I superpathway of pyrimidine deoxyribonucleoside salvage fatty acid biosynthesis ADP-dependent ribonucleotides de novo biosynthesis superpathway of 3',5'-ADP a holo-[AsbD acyl- an N-terminal reductase: fabG (2E)-dodec- catalase/ Arg succinate a carboxylate nucleotides de novo biosynthesis I adenosine nucleotides initiation (type II) NAD(P)H-hydrate arsenite arsenite L-phenylalanyl- carrier protein] a tRNA arginyl-[protein] L-homocysteine a D-amino acid 2'-deoxycytidine 2-enoyl-CoA peroxidase L-lysyl-[protein] a tRNA Phe RS08850 de novo biosynthesis I AIR a (3R)-3- glucose-6- dehydratase/ gln hydrogencarbonate HPI: katG RS05385 hydroxydecanoyl-[acp] acetyl-CoA phosphate NAD(P)H-hydrate H O hydroxyl radical IMP 5-(carboxyamino) nucleoside deaminase: 2 IMP 3-hydroxyacyl- acetyl-CoA dehydrogenase: epimerase: asp imidazole ribonucleotide WH87_RS17715 carboxylase O RNase III mRNA an N-terminal L- uridine 2'3'-cyclic 6-O-trans-keto- ACP dehydratase WH87_RS07330 2 5-methoxy-6- glutamine- IMP zwf (S)-3- NaMN coenzyme A an apo-[aryl- coenzyme A [EntB aryl- NADP + a reduced L,L- an aromatic pyruvate synthase: WH87_RS02110 cytidine deaminase: dCMP carboxyltransferase methylbenzimidazole processing alanyl-[S18 protein monophosphate vernolate mycolyl-trehalose FabZ: fabZ carrier protein] flavodoxin diaminopimelate amino acid RS04405 hydrolyzing dehydrogenase: WH87_RS11370 subunit beta: glucose-6- NADH hydroxydodecanoyl-CoA carrier protein] of 30S ribosome] bifunctional 2',3'- 6-phosphate adenylosuccinate N5-CAIR (d)CMP kinase: glucose-6- ribosomal protein epoxide aspartate/ pyruvate carbamoyl- guaB 3-hydroxyacyl- WH87_RS09360 phosphate cyclic-nucleotide 2'- diaminopimelate trehalose- FtsY synthase: WH87_RS09315 phosphate nicotinate-nucleotide-- S18-alanine N- hydrolase: tyrosine/aromatic carboxylase: phosphate 2'-deoxyuridine [acyl-carrier- malonyl-CoA dehydrogenase: holo-ACP holo-ACP flavodoxin phosphodiesterase/ epimerase: phosphatase: WH87_RS01795 5-(carboxyamino)imidazole isomerase: dimethylbenzimidazole ribonuclease acetyltransferase: WH87_RS08575 aminotransferase: pyc synthase XMP dCDP protein] zwf Secondary Metabolite Degradation synthase: synthase: reductase: 3'-nucleotidase: (9Z)-12,13- WH87_RS18295 otsB ribonucleotide mutase: purE WH87_RS04300 III: rnc an N-terminal N-acetyl-rimI WH87_RS17335 trehalose- small : dehydratase ACP S- 3-oxododecanoyl-CoA phosphoribosyltransferase: WH87_RS05640 WH87_RS09195 WH87_RS12455 an aromatic oxaloacetate nucleoside-diphosphate WH87_RS05640 L-alanyl-[S18 protein dihydroxyoctadeca- meso- trans-keto- RS13705 subunit: carA glutamine- adenylo-succinate asp WH87_RS16545 FabA: fabA malonyltransferase: cobT 3'-UMP 9-enoate diaminopimelate 2-oxo-acid CAIR kinase: WH87_RS05865 fabD 3-ketoacyl- anhydromuropeptides recycling I of 30S ribosome] mono-mycolate carbamoyl- hydrolyzing GMP myo-inositol degradation I D-galacturonate degradation I RNase III HtpX thymidine 6-phospho CoA thiolase: a holo-[aryl- a holo-[EntB aryl- NADPH an oxidized + synthase: guaA adenylosuccinate dUMP dCTP a (2E)-dec-2-enoyl-[acp] 5-methoxy-6- 3',5'-ADP 3',5'-ADP an mRNA fragment H phosphate WH87_RS02425 GlcNAc-1,6- carrier protein] carrier protein] processing flavodoxin lyase: phosphoribosylaminoimidazolesuccinocarboxamide a malonyl-[acp] D-glucono- aldehydo-D- methylbenzimidazole nicotinate synthase anhMurNAc- myo-inositol mRNA WH87_RS13750 trans-2-enoyl- 1,5-lactone galacturonate large GMP synthase: WH87_RS13775 thymidylate synthase: thymidine kinase: decanoyl-CoA L-Ala-γ-D-Glu- ribotide phosphate RS17765 CoA reductase subunit: carB WH87_RS10205 WH87_RS16545 ketoacyl-ACP 6-phosphogluconolactonase: DAP-D-Ala inositol 2- glucuronate guanine and guanosine salvage family synthase III: fabH pgl acyl-CoA isomerase: AMP SAICAR thymidylate synthase: dehydrogenase: an [HPr]- cytidine 2',3'-cyclic UgpC : protein: fabV dehydrogenase: uxaC 5-methoxybenzimidazole NaMN phosphoenol coenzyme A [EntF L-seryl- glycerophosphoserine a ribonucleoside a single a holo [BryU acyl- DNA with lesion roseoflavin histidinol WH87_RS16180 D-gluconate iolG monophosphate asp MeOH carbamoyl asp WH87_RS05950 F6P L-histidine pyruvate carrier protein] triphosphate adenylosuccinate an acetoacetyl-[acp] 6-phosphate WH87_RS02435 stranded DNA bifunctional 2',3'- carrier protein] excinuclease bifunctional phosphate : pyrimidine deoxyribonucleotides de novo biosynthesis I a decanoyl-[acyl-carrier protein] scyllo-inosose D-tagaturonate aspartate/ histidinol catalase/ RS05380 guanosine N-acetyl-β-D- L-alanyl-γ-D- cyclic-nucleotide 2'- ACP S- ABC subunit UvrA: riboflavin kinase/ lyase: WH87_RS13750 phosphogluconate class II fructose- (2E)-dec-2-enoyl-CoA dehydrogenase: peroxidase WH87_RS03980 glucosamine-1,6- glutamyl-meso-2,6- nicotinate-nucleotide-- phosphoenolpyruvate- glycerophosphodiester phosphodiesterase/ malonyltransferase: tyrosine/aromatic GDP UDP CTP purine-nucleoside beta-ketoacyl- dehydratase: holo-ACP WH87_RS09140 FAD synthetase: hisD HPI: katG aspartate dTMP bisphosphatase: anhydro-N-acetyl- diaminopimeloyl- myo-inosose-2 dimethylbenzimidazole -protein phosphodiesterase: DNA : aminotransferase: AICAR vitamin B12-dependent phosphorylase: deoD ACP synthase WH87_RS17685 synthase: 3'-nucleotidase: fabD [+ 3 isozymes] WH87_RS17515 porin carbamoyltransferase glpX β-D-muramate D-alanine dehydratase: iolE phosphoribosyltransferase: phosphotransferase: ptsP WH87_RS05735 WH87_RS12405 a malonyl- WH87_RS17335 ADP ribonucleotide dTMP kinase: purine-nucleoside II: fabF WH87_RS05640 WH87_RS12455 DNA without roseoflavin his formaldehyde catalytic subunit: bifunctional class 1 fructose- 3D-(3,5/4)- D-altronate cobT [BryU acyl- oxaloacetate reductase: CDP phosphorylase: KDGP 3'-cmp lesion 5'-phosphate RS14465 WH87_RS03015 nucleoside- vitamin B12- phosphoribosylaminoimidazolecarboxamide WH87_RS03270 [+ 2 isozymes] long-chain fatty bisphosphatase: (S)-3- trihydroxycyclohexane- carrier protein] WH87_RS11375 an [HPr protein]- a holo-[EntF diphosphate dependent vitamin B12- WH87_RS07555 vitamin B12-dependent altronate π sn-glycerol ssDNA/pppN(pN) formyltransferase/IMP cyclohydrolase: purH dTDP guanine acid activation WH87_RS06385 hydroxydecanoyl-CoA 1,2-dione N -phospho- pyruvate 3',5'-ADP L-seryl-carrier ser kinase: ribonucleotide dependent class 1b ribonucleoside- ribonucleotide a 3-oxododecanoyl-[acp] L-alanyl-γ-D- dehydratase: 5-methoxybenzimidazole 3-phosphate hybrid 1,6-anhydro-N- 3D-(3,5/4)- nicotinate L-histidine n -1 N-carbamoyl- ribonucleotide FAICAR nucleoside-diphosphate a long-chain bifunctional β-D-fructose 1,6- glutamyl-meso- protein] RS02215 WH87_RS05865 reductase: diphosphate reductase: acetyl-β-muramate trihydroxycyclohexane- WH87_RS02650 ribotide phosphate L-aspartate reductase: kinase: WH87_RS05865 xanthine 3-oxoacyl-[acyl- fatty acid 4-hydroxy-2- bisphosphate diaminopimelate WH87_RS07555 reductase: nrdF nrdE WH87_RS07555 long-chain fatty DHAP anhydro-N- 1,2-dione acylhydrolase 2-dehydro-3- RS18435 WH87_RS07555 bifunctional phosphoribosyltransferase: carrier-protein] oxoglutarate fructose- dihydroorotase: class 1b dUDP class 1b ribonucleoside- dTTP acid--CoA ligase: acetylmuramic (decyclizing): iolD deoxy-D-gluconate phosphoribosylaminoimidazolecarboxamide WH87_RS13450 reductase: fabG aldolase/2- 3-oxodecanoyl-CoA 1402 (2Z)-2- GTP WH87_RS02440 bisphosphate a 2,3,4-saturated a cytidine a negatively a [protein]- WH87_RS00675 ribonucleoside- class 1b formyltransferase/IMP cyclohydrolase: purH nucleoside-diphosphate diphosphate dehydro-3-deoxy- triose-phosphate acid kinase: 5-hydroxybenzimidazole NaMN a peptidoglycan dimer (generic) coenzyme A dihydrolipoamide a holo [BryP acyl- ethanol hypoxanthine a long-chain aldolase class I: 5-deoxy-D-glucuronate 1,2-diacyl-sn- VibB in 16S rRNA supercoiled DNA hydroxyhexa- L-histidine diphosphate ribonucleoside- kinase: WH87_RS05865 reductase: nrdF nrdE a (3R)-3- 3-ketoacyl- WH87_RS16035 carrier protein] hypoxanthine phosphoribosyltransferase: hpt fatty acyl-CoA phosphogluconate WH87_RS02005 isomerase: glycerol 3-phosphate CTP pyruvate 16S rRNA DNA 2,5-dienoate FtsE (S)-dihydroorotate reductase: diphosphate hydroxydodecanoyl-[acp] CoA thiolase: N-acetyl-D- 2-keto-4- catalase/ dUTP dCDP aldolase: eda WH87_RS03190 superpathway of β-D- 5-deoxy- ACP S- topoisomerase : IMP dehydrogenase (cytidine(1402)-2'-O) pentenoate xanthine peroxidase RS14600 nrdF nrdE reductase: adenine salvage 3-hydroxyacyl- WH87_RS02425 muramate 6- nicotinate-nucleotide-- lytic transglycosylase malonyltransferase: WH87_RS13935 quinone- GMP glucuronosides degradation glucuronate KDGP phosphatidate holo-ACP complex -methyltransferase: IV subunit B: parE dehydrogenase: HPI: katG nrdF nrdE dUTP diphosphatase: nucleoside-diphosphate Aromatic Compound Biosynthesis phosphate dimethylbenzimidazole domain-containing hydratase: ACP dehydratase D-glyceraldehyde octanoyl-CoA isomerase: iolB synthase: dihydrolipoamide rsmI fabD [+ 2 isozymes] a [protein]- dependent WH87_RS09640 kinase: WH87_RS05865 N-acetylmuramic β protein: WH87_RS10055 cytidylyltransferase: a 2'-O- a malonyl- WH87_RS06485 xdhB xdhA FabZ: fabZ 3-phosphate a -D-glucuronoside 5-dehydro-2- phosphoribosyltransferase: WH87_RS05640 acetyltransferase: (S)-4-hydroxy- N-phospho- acetaldehyde dihydroorotate dADP nucleoside triphosphate chorismate biosynthesis I acid 6-phosphate [+ 4 isozymes] WH87_RS03705 methylcytidine 1402 [BryP acyl- a relaxed DNA xanthine dGDP dCTP adenine 3-hydroxyacyl- acyl-CoA deoxy-D-gluconate bifunctional cobT 2-oxohexanoate dehydrogenase: 3-(4-hydroxyphenyl) type I WH87_RS03600 in 16S rRNA carrier protein] L-histidine RS16775 pyrophosphohydrolase: dehydrogenase: etherase: 4-hydroxy-2- WH87_RS16930 [acyl-carrier- pyruvate biosynthesis glyceraldehyde- 5-dehydro-2- a holo-[VibB aryl- S-acetyldihydrolipoamide RS01680 nucleoside- mazG D-erythrose WH87_RS02435 WH87_RS05715 GlcNAc-1,6-anhydro- a CDP-2,3,4-saturated- 3',5'-ADP nucleoside- protein] 3-phosphate deoxygluconokinase: oxoglutarate a lipid II PRPP diphosphate 5-aminoimidazole ribonucleotide biosynthesis I 4-phosphate 5-hydroxybenzimidazole nicotinate MurNAc-pentapeptide carrier protein] orotate diphosphate dUMP adenine dehydratase 3-deoxy-7- dehydrogenase: N-acetylmuramic aldolase/2- diacylglycerol adenine deaminase: ade tyr (2E)-oct-2-enoyl-CoA D-glucopyranuronate iolC ribotide phosphate kinase: kinase: phosphoribosyltransferase: phosphoheptulonate acid 6- dehydro-3-deoxy- a reduced thymidylate synthase: guanine and guanosine salvage II FabA: fabA aspartate/ gap 5-dehydro-2-deoxy-D- orotate WH87_RS05865 WH87_RS05865 PRPP WH87_RS12720 synthase: phosphate phosphogluconate H O c-type WH87_RS10205 tyrosine/aromatic gluconate 6-phosphate 2 phosphoribosyltransferase: WH87_RS11770 etherase: murQ aldolase: eda cytochrome RS07125 a (2E)-dodec-2-enoyl-[acp] 13-DPG an N-terminal L- 3-aci- a cytidine 1402 a guanine 527 a [protein]- phosphoenol RS19240 an oxidized thymidylate synthase: hypoxanthine aminotransferase: an L-arginyl- glycerophosphoglycerol + WH87_RS05645 dGTP dATP amidophosphoribosyltransferase: N-acetyl-D- meso-diaminopimelate α FMN NAD(P)H H a folate Ins(1)P L-tyrosine a DNA segment WH87_RS16180 guanosine 3-deoxy-7- 3-(4- WH87_RS17335 UDP-N-acetyl- -D-muramoyl- aspartyl-[protein] [tRNA Arg ] nitropropanoate in 16S rRNA in 16S rRNA pyruvate O c-type WH87_RS06040 (S)-3- glucosamine aldehydo-D-glucuronate D-glyceraldehyde 2 a reduced AMP trans-2-enoyl- phosphoheptulonate hydroxyphenyl) phosphoglycerate L-alanyl-D-glutamate 16S rRNA 16S rRNA dihydrofolate inositol phosphate cytochrome xanthine hydroxyoctanoyl-CoA 6-phosphate pyruvate phosphotyrosine H O c-type orotidine 5'- 5-phospho-β- dTMP CoA reductase synthase class II: 3-phosphate (cytosine(1402)-N(4) (guanine(527)-N(7) reductase: recombinase pyruvate 2 gly phosphoribosyltransferase: : pgk glucuronate nitronate glycerophosphodiester monophosphatase: protein cytochrome family N-acetylglucosamine- flavin reductase: WH87_RS16165 RecA: recA kinase: pyk cytochromean oxidized phosphate D-ribosylamine dTMP kinase: WH87_RS06520 3-phospho- isomerase: DHAP 3-oxopropanoate arginyltransferase: )-methyltransferase )-methyltransferase WH87_RS02990 phosphatase: c oxidase RS02235 WH87_RS13450 protein: fabV 3-deoxy- 6-phosphate UDP-N-acetylmuramoyl- monooxygenase: phosphodiesterase: uxaC WH87_RS06360 4 RsmH: rsmH 7 RsmG: rsmG [+ 2 isozymes] a DNA segment O c-type WH87_RS03270 guanine D-arabino- D-glycerate L-alanyl-D-glutamate-- WH87_RS05600 WH87_RS12015 WH87_RS05735 an N - an N - [+ 4 isozymes] WH87_RS13425 2 a reduced orotidine-5'- phosphoribosylamine- hypoxanthine deacetylase: nagA a [protein]- in reverse pyruvate cytochrome superpathway of pyrimidine adenine and heptulosonate 2, 6-diaminopimelate methylcytidine 1402 methylguanine 527 a 7,8-dihydrofolate myo-inositol H O c-type phosphate dTDP phosphoribosyltransferase: hpt a dodecanoyl-[acp] 2,3-bisphosphoglycerate- 3-oxooctanoyl-CoA D-glucosamine D-fructuronate 2 adenosine salvage I -glycine ligase: purD L-tyrosine orientation cytochrome cytochrome decarboxylase: nucleobases salvage xanthine 7-phosphate 6-phosphate D-galactonate degradation ligase: WH87_RS16325 an N-terminal [unspecified in 16S rRNA in 16S rRNA an oxidized nucleoside-diphosphate xanthine and dependent + c oxidase phosphoribosyltransferase: 3-dehydroquinate a tRNA Arg L-arginiyl-L- 3-oxopropanoate nitrite glycerol sn-glycerol FMNH NAD(P) pyrF uracil xanthosine salvage IMP phosphoglycerate 3-ketoacyl- acetyl-CoA degradation 2 O c-type CMP kinase: WH87_RS05865 phosphoglucosamine 3-phosphate 2 RS16770 GAR WH87_RS13450 beta-ketoacyl- synthase: CoA thiolase: D-galactonate UDP-N-acetyl-α-D-muramoyl-L-alanyl- aspartyl-[protein] products] cytochrome UMP uracil adenosine phosphorylation mutase: mutase: RS14950 dTTP hypoxanthine ACP synthase WH87_RS14495 WH87_RS02425 γ-D-glutamyl-meso-2,6-diaminopimelate phosphoribosyltransferase: purine-nucleoside phosphoribosylglycinamide WH87_RS08355 WH87_RS01870 D-mannonate UMP kinase: CMP xanthosine phosphoribosyltransferase: hpt II: fabF D-galactonate WH87_RS11405 phosphorylase: deoD formyltransferase: 3-dehydroquinate α-D-glucosamine (d)CMP kinase: laurate 2-phospho- hexanoyl-CoA dehydratase: WH87_RS03720 UMP purine-nucleoside purine-nucleoside [+ 2 isozymes] mannonate UDP-N-acetyl- decaprenyl-diphospho-N- 966 WH87_RS03100 D-glycerate 1-phosphate an N-terminal L- an L-arginyl- a single- sn-glycero-3- + a guanine sn-glycerol WH87_RS09315 GMP WH87_RS00405 α FMN NADH H a holo [PedN acyl- (E)-caffeoyl-CoA CAIR D-glucopyranose UDP phosphorylase: phosphorylase: deoD acyl-CoA dehydratase: 4-deoxy-L-threo-hex-4- -D-glucosamine acetylmuramoyl-pentapeptide Arg Ins(2)P RS16845 UMP kinase: adenine and long-chain fatty bifunctional UDP-N- glutamyl-[protein] [tRNA ] stranded RNA phosphoethanolamine in 16S rRNA 3-phosphate CDP phosphopyruvate uxuA enopyranuronate degradation 2-dehydro-3-deoxy- carrier protein] electron transfer 5-(carboxyamino) xylose WH87_RS03720 WH87_RS11375 FGAR purine-nucleoside adenosine acid--CoA ligase: dehydrogenase: 16S rRNA inositol glycerol-3- RS17375 nucleoside- a 3-oxotetradecanoyl-[acp] hydratase: acetylglucosamine D-galactonate ACP S- adenine nucleoside- phosphorylase: salvage VI WH87_RS02440 WH87_RS02435 2-dehydro-3- 4-deoxy-L-threo-hex- undecaprenyldiphospho- (guanine(966)-N(2) flavoprotein monophosphatase: imidazole isomerase: diphosphate UDP WH87_RS08875 diphosphorylase/ glycerophosphodiester malonyltransferase: phosphate diphosphate phosphoribosylformylglycinamidine WH87_RS11375 3-dehydroshikimate 2-dehydro-3- muramoylpentapeptide beta-N- arginyltransferase: polyribonucleotide flavin reductase: )-methyltransferase subunit beta: WH87_RS02990 ribonucleotide xylA 3-oxoacyl-[acyl- glucosamine-1- deoxy-D-gluconate 4-enopyranuronate phosphodiesterase: dehydrogenase: kinase: nucleoside-diphosphate adenine kinase: synthase: purS purQ purL xanthine lauroyl-CoA phosphopyruvate (2E)-hexenoyl-CoA deoxygalactonokinase: acetylglucosaminyltransferase: nucleotidyltransferase: pnp WH87_RS06360 fabD RsmD: rsmD WH87_RS17330 mutase: purE adenosine WH87_RS05600 WH87_RS05735 a malonyl[PedN an N 2 - [+ 4 isozymes] WH87_RS17270 keto-D-fructose RS10140 WH87_RS05865 carrier-protein] shikimate hydratase: phosphate N- kinase: WH87_RS05865 phosphoribosyltransferase: WH87_RS05865 WH87_RS03640 murG 966 hydrocaffeoyl-CoA AIR gln xanthine reductase: fabG acetyltransferase acyl-carrier methylguanine myo-inositol DHAP UTP WH87_RS12720 FGAM : acyl-CoA hydrolysis dehydrogenase: WH87_RS03220 2-dehydro-3-deoxy- UTP CTP phosphoribosyltransferase: GlmU: glmU 5-dehydro-4-deoxy- an N-terminal protein] in 16S rRNA RS17550 WH87_RS08390 WH87_RS18595 D-galactonate a nucleoside a single- + a (3R)-3- phosphoenol Arg sn-glycerol FMNH NAD WH87_RS13450 α KDGP D-glucuronate decaprenyl-pyrophosphoryl- UDP a tRNA L-arginiyl-L- ethanolamine 2 CTP synthase: CTP synthase: phosphoribosylformylglycinamidine hydroxytetradecanoyl-[acp] a 2,3,4-saturated pyruvate (S)-3- N-acetyl- -D- 6-phosphate diphosphate stranded RNA AMP AMP shikimate (N-acetylglucosamine)-N- glutamyl-[protein] 3-phosphate WH87_RS03200 cyclo-ligase: WH87_RS03105 fatty acyl CoA hydroxyhexanoyl-CoA glucosamine 5-dehydro- WH87_RS03200 3-hydroxyacyl- acyl-CoA pyruvate RS17195 XMP 1-phosphate 4-deoxy-D- 2-oxo-3- acetylmuramyl-(pentapeptide) CTP AIR ACP dehydratase thioesterase: : kinase: pyk bifunctional CTP WH87_RS17505 bifunctional UDP-N- glucuronate deoxygalactonate FabZ: fabZ WH87_RS16550 4-hydroxy-2- a [glycine-cleavage RS00025 a 2,3,4-saturated acetylglucosamine isomerase: 6-phosphate 5-amino-4- RNase R degradation a glycogen a guanine 46 (3E)-5-chloro-2- a [protein]-L- D-ribulose 3-hydroxyacyl- shikimate kinase: pyruvate oxoglutarate complex H protein] PRPP coenzyme A a holo [PedD acyl- methylglyoxal fatty acid diphosphorylase/ kduI aldolase: a sulfurated [sulfur carrier] SAM imidazolecarboxyamide substrate RNA in tRNA oxopent-3-enoate proline (ω = 180) 5-phosphate WH87_RS14500 3-oxohexanoyl-CoA aldolase/2- 6 carrier protein] [acyl-carrier- glucosamine-1- WH87_RS00405 N -octanoyl-L-lysine tRNA 2-keto-4- peptidylprolyl glyoxalase: ribulose- RS01250 Metabolic Regulator shikimate 3- dehydro-3-deoxy- 3-deoxy-D-glycero- ACP S- protein] acetyl-CoA C- phosphate N- glucan 1,4-alpha- (guanosine(46)-N7) pentenoate isomerase: WH87_RS17695 phosphate 3- Biosynthesis phosphate phosphogluconate 2,5-hexodiulosonate 2-dehydro-3-deoxy-6- adenine malonyltransferase: Carbohydrate Biosynthesis dehydratase acetyltransferase: acetyltransferase ribonuclease CoA pyrophosphatase: glucosidase: -methyltransferase hydratase: WH87_RS04325 glyoxalase: epimerase: FabA: fabA aldolase: eda 2-dehydro- phosphogalactonate lipoyl phosphoribosyltransferase: fabD WH87_RS13745 RS07490 ppGpp metabolism 3-phosphoshikimate 1- WH87_RS02425 GlmU: glmU R: rnr WH87_RS12770 WH87_RS08740 7 TrmB: trmB WH87_RS06485 [+ 2 isozymes] WH87_RS14335 3-deoxy-D- aldolase: synthase: lipA WH87_RS12720 a malonyl- an N - 5-chloro-4-hydroxy- a [protein]-L- D-xylulose carboxyvinyltransferase: 46 gluconeogenesis I UDP-N-acetyl- WH87_RS03645 [PedD acyl- methylguanine (R)-lactate O-antigen building blocks biosynthesis (E. coli) GDP-L-fucose UDP-α-D-glucose a (2E)-tetradec-2-enoyl-[acp] butanoyl-CoA D-glyceraldehyde gluconate 5- 2-oxopentanoate proline (ω = 0) 5-phosphate SecG aroA α in tRNA pppGpp -D-glucosamine 3-phosphate pyruvate dehydrogenase carrier protein] biosynthesis I (from biosynthesis stearate biosynthesis a [glycine-cleavage a diribonucleotide a nucleoside 5'- 4'-phosphopantetheine D-glucopyranose a glycogen UDP-α-D- α 3-phosphoshikimate 1- acyl-CoA UDP-N-acetylglucosamine D-glyceraldehyde AICAR 3',5'-ADP (S)-malate -D- D-glucopyranose GDP-D-mannose) trans-2-enoyl- KduD: kduD pyruvate 5'-deoxyadenosine 6 an unsulfurated monophosphate D-glucopyranose II (bacteria and plants) carboxyvinyltransferase: dehydrogenase: 1-carboxyvinyltransferase: 3-phosphate met complex H protein] N galactose glucopyranose 6-phosphate α CoA reductase 2-dehydro-3- [sulfur carrier] OppB UDP- glucose-6- GDP- -D-mannose 6-phosphate bifunctional (p)ppGpp aroA WH87_RS02435 murA -[(R)-lipoyl]-L-lysine 1-phosphateglucose-1-phosphate alpha-D-glucose family deoxy-D-gluconate galactopyranose phosphate GDP-mannose synthetase/guanosine- a palmitoyl-[acp] 5-enolpyruvoyl- phosphate-specific protein: fabV UDP-N-acetyl-α- RS15110 mutase: glf thymidylyltransferase isomerase: 4,6-dehydratase: beta-ketoacyl- shikimate 3- crotonyl-CoA 3',5'-bis(diphosphate) 3'- D-glucosamine- 3 1518 37 malate/lactate/ UDP-Galf RfbA: rfbA phosphoglucomutase: a [pyruvate dehydrogenase E2 D-glyceraldehyde D-sedoheptulose + an N -methyladenine adenine / a 2-(all-trans- guanine dTDP-α-D-glucose WH87_RS04300 GDP-4-dehydro-gmd pyrophosphohydrolase: ACP synthase phosphate H hydrogencarbonate L-cysteate a uridine in tRNA ureidoglycolate WH87_RS11895 a myristoyl-[acp] enolpyruvate a sulfurated [sulfur carrier] SAM protein] N 6 -octanoyl-L-lysine 3-phosphate 7-phosphate in DNA adenine 1519 in 16S rRNA polyprenyl)phenol in tRNA Phe D-ala trp F6P α α-D-glucopyranose WH87_RS05650 II: fabF chorismate dehydrogenase: -D-rhamnose UDP-N- 16S rRNA tRNA aspartate/ tRNA RS10680 dTDP- 1-phosphate synthase: tryptophan 7- GDP-L-fucose beta-ketoacyl- [+ 2 isozymes] acetylmuramate KDGP (adenine(1518)-N(6)/ 2-polyprenylphenol (guanosine(37)-N1) tyrosine/aromatic D-alanine--D- dihydrouridine WH87_RS08045 glucose 4,6- glutamine-- a 3-oxooctadecanoyl- aroC carbonic DNA-3- RS02400 synthase: UTP--glucose- ACP synthase (S)-3- transketolase: adenine(1519)-N(6))- 6-hydroxylase: ubiB -methyltransferase aminotransferase: alanine ligase: synthase halogenase: malate dehydratase: fructose-6- [acp] dehydrogenase: methyladenine 1-phosphate GTP ppGpp II: fabF hydroxybutanoyl-CoA WH87_RS16810 anhydrase: WH87_RS16295 WH87_RS19085 WH87_RS08260 chorismate murB lipoyl synthase: lipA dimethyltransferase a 3-(all-trans 1 TrmD: trmD WH87_RS17335 DusB: dusB dehydrogenase: rfbB phosphate 3-oxoacyl- bifunctional transketolase: tkt WH87_RS18265 glycosylase I: tag an N - a 5,6-dihydrouridine 7-chloro-L- GDP-4-dehydro-6- uridylyltransferase [+ 2 isozymes] RsmA: rsmA -polyprenyl) 37 D-alanyl-D-alanine mdh transaminase UDP-N-acetyl- 4-hydroxy-2- 6 1518 methylguanine 3-sulfopyruvate dTDP-4-dehydro- β GalU: galU [acyl-carrier- N -dimethyladenine in tRNA tryptophan deoxy- -L-galactose α-D-muramate 6 1519 benzene-1,2-diol Phe RS07595 NADP-dependent 6-deoxy-α-D- (isomerizing) nucleoside- bifunctional (p)ppGpp protein] oxoglutarate /N -dimethyladenine in tRNA GDP-L-fucose a 3-oxohexadecanoyl-[acp] D-ribose 5- D-xylulose an apurinic site RS15175 malic enzyme: glucopyranose : glmS UDP-α-D-glucose diphosphate aldolase/2- a [pyruvate dehydrogenase CO H O 3-methyladenine in 16S rRNA synthetase/guanosine- reductase: acetoacetyl-CoA 5'-deoxyadenosine phosphate 5-phosphate 2 2 within DNA synthase: met E2 protein] N 6 -lipoyl-L-lysine an unsulfurated [sulfur carrier] WH87_RS03145 dTDP-4- D-: 3',5'-bis(diphosphate) 3'- 3-oxoacyl-[acyl- fabG dehydro-3-deoxy- oxaloacetate WH87_RS08260 WH87_RS05865 phosphogluconate dehydrorhamnose 6-phosphate pyrophosphohydrolase: carrier-protein] a (3R)-3- acetyl-CoA C- UDP-N-acetyl- β hydroxyoctadecanoyl- aldolase: eda pyruvate 3,5-epimerase: rfbC phosphoglucosamine GDP- -L-fucose WH87_RS05650 reductase: fabG acetyltransferase: α-D-muramoyl- RS03395 undecaprenyl-diphospho-N 37 α-L- 6-O-α-mycolyl- phosphoenolpyruvate dTDP-4-dehydro- mutase: [acp] WH87_RS02425 L-alanyl-γ-D- UDP-N-acetyl-α-D-glucosamine UDP-N-acetyl-α-D-muramoyl- D-xylulose D-erythrose (S)-2,3,4,5- a guanine an N-hydroxy- RS10685 a (3R)-3- γ D-alanyl-D-alanine fumarate (S)-mandelate D-ribofuranose β-L-rhamnose WH87_RS01870 3-hydroxyacyl- D-glyceraldehyde -acetylmuramoyl-L-alanyl- - γ 5-phosphate 4-phosphate asp tetrahydrodipicolinate in tRNA arylamine rhamnopyranose trehalose 6- carboxykinase hydroxyhexadecanoyl-[acp] acetyl-CoA glutamyl-meso-2,6- pyruvate L-alanyl- -D-glutamyl-L-lysine L-rhamnose : dTDP-4- α GDP ACP 3-phosphate D-glutamyl-L-lysyl- D-alanine 2,3,4,5- mandelate racemase: tRNA arylamine N- phosphate (ATP): pckA -D-glucosamine diaminopimelate mutarotase: WH87_RS08965 trehalose- dehydrorhamnose 3-hydroxyacyl- dehydratase undecaprenyldiphospho- tetrahydropyridine- WH87_RS00370 (guanosine(37)-N1) acetyltransferase: 1-phosphate trehalose biosynthesis I UDP-N-acetylmuramoyl- transketolase: WH87_RS17820 phosphatase: reductase: rfbD ACP dehydratase FabZ: fabZ L-aspartate 2,6-dicarboxylate N- mandelate racemase: -methyltransferase WH87_RS08950 ribokinase: phosphoenol bifunctional UDP-N- muramoylpentapeptide beta-N- tripeptide--D-alanyl-D- WH87_RS16810 otsB FliN β FabZ: fabZ oxidase: succinyltransferase: WH87_RS17130 1 TrmD: trmD [+ 2 isozymes] WH87_RS15090 RS10785 pyruvate dTDP- -L- 3-hydroxyacyl- acetylglucosaminyltransferase: an N - an N- β-L- α α acetylglucosamine D-glucopyranose alanine ligase: murF transketolase: tkt WH87_RS02700 dapD D-ribofuranose , '-trehalose rhamnose UDP-α-D-glucose [acyl-carrier- murG (R)-mandelate methylguanine 37 acetoxyarylamine phosphopyruvate diphosphorylase/ 6-phosphate 3-hydroxyacyl- N-succinyl-2-amino- rhamnopyranose 5-phosphate 6-α-mycolate protein] Inorganic Nutrient Metabolism in tRNA hydratase: glucosamine-1- [acyl-carrier- UDP-N-acetyl-α-D-muramoyl-L-alanyl- 6-ketopimelate dehydratase ditrans,octacis-undecaprenyldiphospho- D-glyceraldehyde WH87_RS08875 phosphate N- trehalose-6- protein] UDP γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine F6P 2-iminosuccinate succinate FabA: fabA (aminomethyl)phosphonate degradation N-acetyl-(N-acetylglucosaminyl)muramoyl- 3-phosphate phosphopyruvate acetyltransferase phosphate dehydratase RS10930 RS07620 glyphosate degradation III methylphosphonate dimethyl sulfide assimilatory L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine hydratase: GDP-mannose biosynthesis GlmU: glmU synthase: FabA: fabA a (2E)-octadec- degradation I degradation sulfate reduction III WH87_RS03220 N-acetyl-α-D- WH87_RS13145 2-enoyl-[acp] (aminomethyl)phosphonate II (oxidation) a (2E)-hexadec-2-enoyl-[acp] glyphosate α undecaprenyl-diphospho-N-acetylmuramoyl-L- α D-glucopyranose glucosamine methylphosphonate sulfate UDP-N-acetyl- -D-glucosamine a β-D-galactoside D-threo-7,8- a [protein]- - 3-amino-4- (S)-2- 2-phospho- trans-2- phosphonate dimethyl sulfide alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine F6P hydantoin (+)-muconolactone oxaloacetate ser 6-phosphate 1-phosphate α,α-trehalose phosphonate sulfate dihydroneopterin L-glutamate hydroxybenzoate hydroxyglutarate D-glycerate glucose-6- trans-2-enoyl- enoyl-CoA C-P lyase type B protein-glutamate O- citrate synthase/ RS07650 bifunctional UDP-N- 6-phosphate C-P lyase adenylyltransferase: undecaprenyldiphospho- arylamine N- L-2- RS07690 phosphate CoA reductase reductase (acetamidomethyl)phosphonate system protein dihydropyrimidinase: chloramphenicol O- methyltransferase methylcitrate L-serine acetylglucosamine trehalose- system protein cysN cysD muramoylpentapeptide beta-N- fructose-6- acetyltransferase: hydroxyglutarate isomerase: family family PhnL: phnL dimethyl sulfoxide beta-glucosidase: dihydroneopterin hydA acetyltransferase: CheR: synthase: ammonia-lyase: diphosphorylase/ phosphatase: phosphonate C- PhnL: phnL APS acetylglucosaminyltransferase: WH87_RS08950 oxidase: lhgO WH87_RS04300 protein: fabV protein: fabV α-D-ribose-1-[[+N 2- isozymes] WH87_RS17355 phosphate aldolase: folB catB WH87_RS14995 WH87_RS07300 WH87_RS02755 3-phospho- otsB P lyase system α [+ 2 isozymes] murG a [protein]-L- 3-acetylamino-4- F6P glucosamine-1- -D-ribose-1- phosphoadenylyl- aldolase: fsa 2-oxoglutarate (2S,3S)-2- (phosphonomethyl) N-carbamoylglycine cis,cis-muconate 5 pyruvate D-glycerate phosphate N- a stearoyl-[acp] protein PhnL: phnL methylphosphonate- glutamate-O hydroxybenzoate RS03445 α,α-trehalose a palmitoyl-[acp] glycine] 5-triphosphate sulfate reductase: methylcitrate mannose-1-phosphate acetyltransferase [+ 2 isozymes] 5-triphosphate a non galactosylated -methyl-ester RS11055 phosphoglycerate α alpha-D-ribose 1- WH87_RS19430 ditrans,octacis-undecaprenyldiphospho-N- UDP D-galactopyranose D-glyceraldehyde 6-(hydroxymethyl) glycolaldehyde guanylyltransferase/ GlmU: glmU -D-ribose 1- alpha-D-ribose 1- galactose acceptor dihydroxyacetone kinase: pgk methylphosphonate dimethyl sulfone acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L- 3-phosphate -7,8-dihydropterin mannose-6- (acetamidomethylphosphonate) methylphosphonate sulfite UDP-N-acetyl- 5-triphosphate alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine phosphate isomerase: α 5-triphosphate 5-triphosphate 13-DPG -D-glucosamine diphosphatase: WH87_RS17105 alpha-D-ribose 1- diphosphatase: assimilatory sulfite UgpC α palmitate stearate WH87_RS09870 UDP-N-acetyl- -D- methylphosphonate reductase (NADPH) an L-1- an (S-diacyl-sn- DNA combined with S-(2-hydroxyacyl) a 5' triphospho- RS11085 type I D-mannopyranose WH87_RS09870 a sialyloligosaccharide L,L- reduced riboflavin hydroxypyruvate pyrazinamide (R)-lactate mannosaminouronate long-chain fatty long-chain fatty 5-triphosphate alpha-D-ribose 1- methanesulfinate : WH87_RS15840 phosphatidylethanolamine glyceryl)-L-cysteinyl- exogenous DNA to form glutathione [mRNA] L-homoserine glyceraldehyde- 6-phosphate alpha-D-ribose 1- diaminopimelate biosynthesis acid--CoA ligase: acid--CoA ligase: diphosphatase: methylphosphonate [apolipoprotein] a recombinational junction RNA bifunctional D-lactate 3-phosphate UDP-N-acetyl- methylphosphonate hydrogen sulfide Holliday junction LL-diaminopimelate homoserine O- flavin reductase: hydroxypyruvate glycogen biosynthesis I (from ADP-D-Glucose) WH87_RS02440 WH87_RS02440 WH87_RS09870 5-triphosphate pyrophosphohydrolase: nicotinamidase/ dehydrogenase: triose-phosphate dehydrogenase: α-D-glucosamine 5-triphosphate exo-alpha-sialidase: resolvase RuvX: ruvX aminotransferase: succinyltransferase: WH87_RS06360 isomerase: hyi UDP-N- alpha-D-ribose 1- diphosphatase: apolipoprotein N- hydroxyacylglutathione WH87_RS17925 pyrazinamidase: WH87_RS15425 RS11060 isomerase: gap stearoyl-CoA diphosphatase: WH87_RS12120 crossover junction WH87_RS13485 WH87_RS15800 α-D-mannose acetylglucosamine palmitoyl-CoA hydrolase: gloB pncA RS15470 WH87_RS03190 D-glucopyranose 6-phosphate methylphosphonate WH87_RS00335 acyltransferase: lnt endodeoxyribonuclease a 5'-phospho- (S)-2,3,4,5- tartronate D-glyceraldehyde 1-phosphate α-D-ribose-1-[N- WH87_RS00335 methanesulfonate O-succinyl-L- riboflavin pyrazine-2- pyruvate DHAP 2-epimerase (non- 5-triphosphate α resolution of recombinationalRuvC: ruvC [mRNA] tetrahydrodipicolinate semialdehyde 3-phosphate (phosphonomethyl) -D-ribose-1- homoserine carboxylate mannose-1-phosphate alpha-D-glucose hydrolyzing): diphosphatase: an N-acyl-(S-diacyl- junction formation glycine] 5-phosphate methylphosphonate FMNH2-dependent a 2-acyl-1-lyso- N-acetylneuraminate an oligosaccharide a 2-hydroxy guanylyltransferase/ phosphate-specific WH87_RS08165 WH87_RS00335 sn-glyceryl)-L- glutathione UDP-N-acetyl-α- lipid IV biosynthesis (P. putida) Cell Structure Biosynthesis 5-phosphate alkanesulfonate phosphatidylethanolamine of two intact strands carboxylate A α-D-ribose-1-(2-N- alpha-D-ribose 1- RS07735 mannose-6- phosphoglucomutase: lipid IV biosynthesis (E. coli) peptidoglycan maturation (meso-diaminopimelate containing) alpha-D-ribose 1- cysteinyl-[lipoprotein] D-mannosamine A methylphosphonate monooxygenase: RS11255 fructose- phosphate isomerase: WH87_RS11895 acetamidomethylphosphonate) methylphosphonate UDP-N-acetyl-D- a (3R)-3- 5-phosphate C- ssuD bisphosphate WH87_RS17105 α-D-glucopyranose a (3R)-3- lipid II (meso 5-phosphate 5-phosphate C- mannosamine hydroxydecanoyl- UDP-N-acetyl- P-lyase PhnJ: 2,5-diamino-6-(5- XLLG xyloglucan p-nitrophenyl- a 5,6- 6-O-cis-keto- α hydroxytetradecanoyl- UDP-N-acetyl- alpha-D-ribose 1- (2S)- 2+ aldolase class I: GDP- -D- diaminopimelate containing) P-lyase PhnJ: seleno-L- 20 1-phosphate dehydrogenase: [acp] α-D-glucosamine sulfite phospho-D-ribosylamino) oligosaccharide β-D-galactoside 2-heptaprenylphenol uroporphyrinogen-I dihydrouracil an arylamine mycolyl-trehalose Fe WH87_RS02005 [acp] α-D-glucosamine methylphosphonate 5- WH87_RS00305 homocysteine ethylmalonyl-CoA mannose monofunctional WH87_RS00305 6-phosphate UgpC glucose-1-phosphate wecC phosphate C-P-lyase α pyrimidin-4(3H)-one bifunctional uroporphyrinogen in tRNA tRNA arylamine N- methylmalonyl- α acyl-ACP--UDP-N- biosynthetic 5-phospho- -D-ribose 5-methyltetrahydropteroyltriglutamate- 2-polyprenylphenol trehalose- adenylyltransferase: UDP-N-acetyl- -D- acyl-ACP--UDP-N- carbon- diaminohydroxyphosphoribosylaminopyrimidine decarboxylase: dihydrouridine(20/ acetyltransferase: CoA bacterioferritin: bfr FliP acetylglucosamine O- peptidoglycan PhnJ: WH87_RS00305 1,2-cyclic phosphate - homocysteine S- beta-glucosidase: beta-glucosidase: 6-hydroxylase: ubiB phosphatase: glgC mannosaminuronate acetylglucosamine O- phosphorus deaminase/5-amino-6-(5-phosphoribosylamino) WH87_RS18585 20a) synthase WH87_RS08950 epimerase: mce β acyltransferase: lpxA transglycosylase: carbon-phosphorus methyltransferase: metE WH87_RS17355 WH87_RS17355 otsB -D-fructose 1,6- acyltransferase: lpxA lyase complex α α lyase complex subunit uracil reductase RibD: ribD 3-(all-trans-heptaprenyl) DusA: dusA an N- (2R)- trehalose-cis-keto- 3+ bisphosphate a (1->4)- -D-glucan ADP- -D-glucose mtgA subunit PhnI: selenate reduction 5-amino-6-(5-phospho- coproporphyrinogen I Fe SeMet benzene-1,2-diol 20 acetylarylamine ethylmalonyl-CoA UDP-3-O-[(3R)-3- a nascent peptidoglycan PhnI: WH87_RS00310 a uracil in tRNA mono-mycolate RS11990 class II fructose- glycogen UDP-3-O-[(3R)-3- WH87_RS00310 D-ribosylamino)uracil XXXG xyloglucan hydroxydecanoyl]- γ α-D-ribose 1,5- bisphosphatase: synthase hydroxymyristoyl]-N- with (L-alanyl- -D-glutamyl- 5-phospho-α-D-ribose 5-phospho-α- D-galactopyranose D-galactopyranose 4-nitrophenol N-acetyl-α-D- bisphosphate selenate oligosaccharide RS12055 GlgA: glgA acetyl-α-D-glucosamine meso-2,6-diaminopimeloyl-D- 1,2-cyclic phosphate D-ribose 1,2- glpX glucosamine sulfate UDP-3-O-acyl-N- alanyl-D-alanine) pentapeptide ribose 1,5- cyclic phosphate class 1 fructose- a (1->4)-α-D-glucan UDP-3-O-acyl-N- adenylyltransferase: acetylglucosamine 2,5-diamino-6-(5- 1915 bisphosphatase: α bisphosphate cysN cysD 2-amino-6-[1-hydroxyethyl]- XLXG xyloglucan a pseudouridine 3-amino-4- (2R,3S)-3- 6,8- UDP- -D-galactofuranose acetylglucosamine adenosine 5'- 2-nonaprenylphenol (R)-pantothenate L-fuconate glyoxylate FlhB 1,4-alpha-glucan deacetylase: phosphokinase: phospho-D-ribitylamino) 7-methyl-7,8-dihydropterin oligosaccharide hydroxybenzaldehyde WH87_RS06385 biosynthesis deacetylase: phosphoselenate in 23S rRNA isopropylmalate dihydroxypurine branching WH87_RS16275 phnN pyrimidin-4(3H)-one 23S rRNA arylamine N- type I L-fuconate RS05925 WH87_RS16275 α-D-ribose 1,5-bisphosphate α-D-ribose 1,5- bifunctional 2-amino-4-hydroxy-6- 3-isopropylmalate xanthine malate F6P α protein GlgB: glgB UDP-3-O-(3- a nascent peptidoglycan a nascent peptidoglycan a mature peptidoglycan with (pseudouridine(1915)- 2-polyprenylphenol pantothenate UDP- -D-glucose UDP-3-O-(3- diaminohydroxyphosphoribosylaminopyrimidine hydroxymethyldihydropteridine beta-glucosidase: acetyltransferase: dehydrogenase: dehydratase: dehydrogenase: synthase G: PRPP biosynthesis hydroxymyristoyl) with (L-alanyl-γ-D-glutamyl- with D,D cross-links (meso- (L-alanyl-γ-D-glutamyl-meso- PRPP bisphosphate N(3))-methyltransferase 6-hydroxylase: ubiB kinase: UDP-glucose 4- hydroxydecanoyl) ribose 1,5-bisphosphate deaminase/5-amino-6-(5-phosphoribosylamino) diphosphokinase: folK WH87_RS17355 WH87_RS08950 leuB WH87_RS11635 xdhB xdhA WH87_RS13055 glucose-6- a glycogen -α-D-glucosamine meso-2,6-diaminopimeloyl- diaminopimelate containing) 2,6-diaminopimeloyl-D-alanyl- [1-(2-amino-7-methyl-4-oxo- RlmH: rlmH WH87_RS02950 2-dehydro-3- epimerase GalE: galE -α-D-glucosamine adenine uracil reductase RibD: ribD an N 3 - 3-(all-trans-nonaprenyl) 3-acetylamino-4- 4-methyl-2- FliL phosphate α D-ribose 5- UDP-3-O-(3- D-alanine) tetrapeptide D-alanine) pentapeptide phosphokinase: phnN selenite (R)-4'- urate (S)-malate UDP- -D-galactose UDP-3-O-(3- phosphoribosyltransferase: 5-amino-6-(5-phospho- 7,8-dihydro-3H-pteridin- 1915 benzene-1,2-diol hydroxybenzaldehyde oxopentanoate deoxy-L-fuconate isomerase: phosphate hydroxymyristoyl) methylpseudouridine phosphopantothenate ribose-phosphate hydroxymyristoyl) PRPP WH87_RS12720 D-ribitylamino)uracil 6-yl)]ethyl diphosphate XXXG xyloglucan RS12210 WH87_RS04300 UDP-galactopyranose glucosamine N- L,D-transpeptidase: L,D-transpeptidase: D-galactopyranose in 23S rRNA glucosamine N- a mature peptidoglycan oligosaccharide mutase: glf pyrophosphokinase: prs acyltransferase: WH87_RS17965 WH87_RS17965 D-glucopyranose acyltransferase: with D,D cross-links (meso- adenine diphosphate UDP-Galf PRPP lpxD [+ 5 isozymes] a nascent peptidoglycan with [+ 5 isozymes] a mature peptidoglycan RS12175 6-phosphate lpxD diaminopimelate containing) phosphoribosyltransferase: UDP-2-N,3-O-bis[(3R)- γ γ selenodiglutathione 10 XXLG xyloglucan 55 (L-alanyl- -D-glutamyl-meso- with (L-alanyl- -D-glutamyl- WH87_RS12720 inorganic 5-amino-6-(5-phospho- 4a-hydroxy-N - a uridine meso- adenosyl-cob(III) GDP-β-L-fucose UDP-2-N-[(3R)-3- 3-hydroxytetradecanoyl]- a nascent peptidoglycan a nascent peptidoglycan assimilatory uroporphyrinogen-III 2-decaprenylphenol DHAP citrate 2,6-diaminopimelate) tripeptide meso-2,6-diaminopimeloyl- diphosphatase: urea cycle D-ribosylamino)uracil formyltetrahydrofolate oligosaccharide in tRNA diaminopimelate yrinate a,c-diamide hydroxydodecanoyl]- α γ sulfate reduction IV bifunctional uroporphyrinogen-III C- RS12260 -D-glucosamine with L,D cross links (meso- with (L-alanyl- -D-glutamyl- D-alanine) tetrapeptide diphosphate WH87_RS18145 tRNA cobyric acid GDP-L-fucose methylglyoxal aconitate 3-O-[(3R)-3- 4a-hydroxytetrahydrobiopterin methyltransferase: cobA 2-polyprenylphenol diaminopimelate UDP-2,3- diaminopimelate containing) meso-2,6-diaminopimeloyl- diaminohydroxyphosphoribosylaminopyrimidine pseudouridine(55) synthase: synthase: synthase: hydratase hydroxydecanoyl]- sodium-translocating sulfate ammonium dehydratase: WH87_RS18115 beta-glucosidase: 6-hydroxylase: ubiB dehydrogenase: diacylglucosamine glycine) tetrapeptide inorganic deaminase/5-amino-6-(5-phosphoribosylamino) uroporphyrinogen-III C- WH87_RS17655 WH87_RS08260 WH87_RS14965 AcnA: acnA RS12220 α-D-glucosamine a mature peptidoglycan with pyrophosphatase: sulfate WH87_RS17355 synthase TruB: truB WH87_RS04460 glutathioselenol uracil reductase RibD: ribD 10 55 GDP-4-dehydro- diphosphatase: γ diphosphatase: glutamine- an N -formyl- methyltransferase: cobA 3-(all-trans-decaprenyl) a pseudouridine UDP-2,3- (L-alanyl- -D-glutamyl-meso- WH87_RS18170 adenylyltransferase: 5-amino-6-(5-phospho- (S)-2,3,4,5- adenosylcobyrate α-D-rhamnose methylglyoxal D-threo-isocitrate WH87_RS15895 WH87_RS18145 arg 7,8-dihydrofolate precorrin-2 benzene-1,2-diol in tRNA diacylglucosamine a mature peptidoglycan 2,6-diaminopimelate) tripeptide cysN cysD hydrolyzing D-ribitylamino)uracil tetrahydrodipicolinate PhnE with L,D cross-links (meso- a mature peptidoglycan sodium-translocating carbamoyl- XXXG xyloglucan diphosphatase: lipid X phosphate APS D-galactopyranose γ oligosaccharide WH87_RS15895 diaminopimelate containing) with (L-alanyl- -D-glutamyl- pyrophosphatase: phosphate PstC lipid A meso-2,6-diaminopimeloyl- WH87_RS18170 adenylyl-sulfate hydrogen selenide synthase lipid X (P. putida) disaccharide glycine) tetrapeptide kinase: cysN argininosuccinate arginase: small phosphate synthase: lyase: argH rocF subunit: carA FliJ PAPS WH87_RS03675 argininosuccinate carbamoyl- lipid A disaccharide phosphoadenylyl- L-arginino- lyase: argH phosphate RseP L-ornithine lipid A (E. coli) sulfate reductase: succinate synthase disaccharide two-component alkanesulfonate monooxygenase WH87_RS19430 large (P. putida) argininosuccinate subunit: carB RS16025 sulfite synthase: an alkylsulfonate FMNH carbamoyl RS08065 lipid IV (E. coli) 2 WH87_RS18200 A phosphate lipid IV thiosulfate oxidation III ornithine A (P. putida) (multienzyme complex) carbamoyltransferase: argF RS12645 hydrogen sulfide a [SoxY protein]-L-cysteine L-citrulline RS12505

FMNH2-dependent alkanesulfonate flavin reductase: a [SoxY protein]-S- RS12885 RS08250 monooxygenase: WH87_RS06360 sulfosulfanyl-L-cysteine L-cysteine degradation III ssuD cytochrome c: WH87_RS17040 cys polyphosphate RS00380 RS12900 metabolism a [SoxY protein]-S- a [SoxY protein]-S disulfanyl-L-cysteine -sulfanyl-L-cysteine long chain polyphosphate an aldehyde FMN 3-mercaptopyruvate UgpC RS13005 polyphosphate a [SoxY protein]-S-(2- 3-mercaptopyruvate kinase 2: ppk2 sulfodisulfanyl)-L-cysteine : [+ 2 isozymes] sseA

RS03855 RS00410 long chain hydrogen sulfide pyruvate polyphosphate a reduced a reduced plastocyanin plastocyanin an oxidized an oxidized phosphonate plastocyanin plastocyanin an (aminoalkyl)phosphonate spermidine a polyamine D-ribopyranose phosphate ammonium an alkylphosphonate putrescine

cytochrome cytochrome CysW RS12960 RS12635 RS08060 RS12255 RS05920 FliM RS11170 RS15390 RS10925 RS10840 RS15215 RS15115 RS00010 RS01110 RS06910 RS09905 RS01385 TatA RS13850 UgpC RS08925 MurJ RS14125 RS14065 RS06935 RS13920 PotA RS02640 RS12305 PhnC PotA RS02085 RS19415 RS14050 RS06305 CysW RS08715 RS14730 Amt RS09340 RS02125 RS09725 RS16735 RS10120 RS17370 RS00020 RS06675 RS07590 RS10895 RS05805 RS11080 RS03585 RS12060 RS12190 RS12345 RS16020 RS12835 RS13170 c oxidase c oxidase

phosphonate spermidine a polyamine D-ribopyranose ammonium phosphate an (aminoalkyl)phosphonate putrescine O O an alkylphosphonate 2 2 H O H O 2 2 This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.