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3(59) `2017 Issn 1813 1905 Якутский Медицинский Журнал 3(59) `2017 ISSN 1813 1905 ЯКУТСКИЙ МЕДИЦИНСКИЙ ЖУРНАЛ YAKUT MEDICAL SCIENTIFIC - PRACTICAL JOURNAL OF THE YAKUT SCIENCE CENTRE JOURNAL OF COMPLEX MEDICAL PROBLEMS The founder ISSN 1813 1905 The Yakut Science Centre of Complex Medical Problems 3(59) ‘2017 Editor- in- chief Tomskiy M.I., MD, Professor YAKUT Editorial Board: Deputy Chief Editor Nikolaev V.P., MD Executive secretary Nikolaev V.P., MD MEDICAL Editorial Council: Aftanas L.I., MD, Professor, Acad. RAMS (Novosibirsk) JOURNAL Voevoda M.I., MD, Professor, Corresponding Member RAMS (Novosibirsk) Ivanov P.M., MD, Professor (Yakutsk) Kryu- SCIENTIFIC - PRACTICAL JOURNAL bezi Eric, MD, Professor (France) Maksimo- OF THE YAKUT SCIENCE CENTRE OF COMPLEX va N.R., MD (Yakutsk) MEDICAL PROBLEMS Mironova G.E., Doctor of Biology, Professor (Yakutsk) Mikhailova E.I., Doctor of Pedagogics, Pro- fessor (Yakutsk) Quarterly Nikitin Yu.P., MD, Professor, Acad. RAMS (Novosibirsk) Registered by the Office of the Federal Service on Odland John, MD, Professor (Norway) supervision in the field of communications, information Puzyrev V.P., MD, Professor, Acad. RAMS technologies and mass communications in the Republic (Tomsk) Sakha (Yakutia) December 13/2016 Reutio Arya, MD, PhD, Professor (Finland) Fedorova S.A., Doctor of Biology (Yakutsk) Registration number PI No.ТU 14-00475 HusebekAnne, MD, Professor (Norway) Subscription index: 78781 Khusnutdinova E.K., Doctor of Biology, Pro- Free price fessor (Ufa) Editors: "Yakut Medical Journal" is included in the approved by Chuvashova I.I., the Higher Attestation Commission of the Russian Kononova S.l. Federation List of leading peer-reviewed scientific Semenova T.F. (English) journals and publications, in which the main scientific - results of dissertations for the acquisition of scientific degrees of Doctor and Candidate of science on biological sciences and medicine should be published. Cover Ignatiev V.N. The responsibility for the translated versions The journal is included in the international directory of the articles rests solely with the authors. system under periodic and proceeding editions “Ulrich’s International Periodicals Directory” 2 YAKUT MEDICAL JOURNAL CONTENTS MATERIALS OF THE SCIENTIFIC-PRACTICAL CONFERENCE WITH INTERNATIONAL PARTICIPATION «MODERN APPROACHES AND PROSPECTS OF GENETIC RESEARCH IN YAKUTIA», SEPTEMBER 7, 2017, YAKUTSK 5 Akhmadeeva G.N., Khidiyatova I.M., Nasibullin T.R., Baitimerov A.R., Magzhanov R.V., Khusnutdinova E.K. Research of association of polymorphic variants of genes dopamine system’s (DRD1, DRD2, DRD3, DRD4, TH, COMT and MAO-B) with idiopathic Parkinson’s disease 9 Gimalova G.F., Karunas A.S., Khantimerova E.F., Zagidullin Sh.Z., Khusnutdinova E.K. Investigation of the role of polymorphic variants of cytokine genes in the development of urticaria in the Republic Bashkortostan 12 Gotovtsev N.N., Barashkov N.A., Borisova Т.V., Pak M.V., Alekseeva M.P., Innokentieva N.N., Loskutova K.S., Pshennikova V.G., Rafailov A.M., Lekhanova S.N., Fedorova S.A. Approbation of the molecular genetic method for the diagnosis of Helicobacter pylori infection in Yakutia 16 Zvenigoroski V., Fedorova S.A., Hollard K., Gonzales A., Alekseev A., Bravina R.I., Krubesi E., Keizer K. A new approach to genetic kinship testing in Yakut archaeology 21 Karpova A.G., Savostyanov A.N., Bazovkina D.V., Tamozhnikov S.S., Saprygin A.E., Proshina E.A., Borisova N.V., Aftanas L.I. Allelic polymorphism of the serotonin transporter as a formation factor of the behavioral cognitive control in the Yakuts 24 Klimova T.M., Zakharova R.N., Fedorov A.I., Baltakhinova M.E., Ammosova E.P., Fedorova V.I. ALA54THR polymorphism of the FABP2 gene and metabolic syndrome in the Yakut population 27 Kononova S.K., Sidorova O.G., Platonov F.A., Izhevskaya V.L., Khusnutdinova E.K., Fedorova S.A. Genetic testing and informed consent for type I spinocerebellar ataxia, the most common hereditary disease in the Yakut population 31 Neustroeva T.S., Tikhonov D.G., Platonov F.A., Yakovleva N.V. Indicators of quality of life and communication of patients with type I spinocerebellar ataxia 34 Nikolaev V.M., Zasimova E.Z., Aleksandrova E.N., Grigorieva L.V., Ivanova F.G., Golderova A.S., Ivanov P.M., Fedorova S.A. Analysis of associations of genetic polymorphisms 481C> T, 590G> AI 857G> A gene of the enzyme N-acetyltransferase 2 (NAT2) with the risk of lung cancer in the Yakuts 37 Osakovsky V.L., Sivtseva T.M. Genome and genetic health of the Yakut ethnos Pshennikova V.G., Barashkov N.A., Soloviev A.V., Romanov G.P., 40 Teryutin F.M., Posukh O.L., Sazonov N.N., Dzhemileva L.U., Khusnutdinova E.K., Tomsky M.I., Fedorova S.A. Informative parameters of predictive in silico computer programs in assessing clinical significance of missense variants of GJB2 (Cx26) gene 46 Romanova A.N., Voevoda M.I., Maksimov V.N. Association of four single nucleotide polymorphisms with arterial hypertension and myocardial infarction in the RS(Ya): ethnic and gender features 3’ 2017 3 49 Romanov G.P., Barashkov N.A., Teryutin F.M., Pshennikova V.G., Soloviev A.V., Rafailov A.M., Sazonov N.N., Dzhemileva L.U., Posukh O.L., Khusnutdinova E.K., Fedorova S.A. Frequency of m.1555a>g mutation in MT-RNR1 gene of mitochondrial DNA among deaf individuals in Yakutia 52 Savostyanov A.N., Saprygin A.E., Bocharov A.V., Ayusheeva Т.А., Meshkova V.A., Bazovkina D.V., Karpova A.G., Borisova N.V., Aftanas L.I. Interrelation of EEG reactions in conditions of recognition of emotional vocabulary in Yakuts with allele polymorphisms of the serotonin transporter 55 Sivtseva T.M., Osakovski V.L. Genetics of Vilyui encephalomyelitis 58 Sidorova O.G., Kononova S.K., Platonov F.A., Barashkov N.A., Fedorova S.A., Khusnutdinova E.K., Izhevskaya V.L. Analysis of repeated cases of prenatal DNA testing of spinocerebellar ataxia I in Yakutia 60 Fedorova S.A. Origin of the Yakuts: molecular-genetic reconstructions in comparison with the hypotheses of historians 65 Chugunova S.A., Nikolaeva T.Ya., Ignatieva A. V., Popov M.M. Genetic risk factors of thrombofilia in a young ischemic stroke patient (clinical case report) 69 Yavlovskaya L. L., Khusnutdinova E.K., Anisimova N.F., Lazarenko V.I. The hypothesis of the development of diabetic retinopathy in the Yakuts at type 2 diabetes mellitus Original research 73 Begiev O.V., Vinokurova Ya.V., Begiev V.G., Golderova A.S. Features of deviant behavior in children with hearing impairment in the RS(Ya) 76 Shantanova L.N., Nikolaev S.M., Mathanov I.E., Gulyaev S.M., Tatarinova N.K., Muruyev B.A., Banzaraksheev V.G., Razuvaeva Ya.G. Stress-protective activity of the extract of Fornicium uniflorum L. Methods of diagnosis and treatment 80 Lazarenko V.A., Antonov A.E., Prasolov A.V., Churilin M.I. Evaluating the efficiency of neural network prognosis of health quantitative indicators in patients with diseases of the hepatopancreatoduodenal zone 82 Banzaraksheev V.G., Razuvaeva Ya.G. Pathomorphological and pathophysiological evaluation of liver changes in white rats with experimental dyslipidemia and its correction Organization of health, medical science and education Kazakova E.V. 85 Assessment of population, age and sex structure change in territorial subjects of the Russian Federation in the territory of the FEFD Hygiene, sanitation, epidemiology and medical ecology Ivanov P.M., Abramov A.F., Tomsky M.I., Golderova A.S., Romanova A.N., 89 Kipriyanova N.S., Nikolaev V.M., Afanasyeva L.N., Nikolaeva T.I., Zharnikova T.N.,Makarova N.N., Myreeva S.A. The environment and incidence of malignant neoplasms in the population of the diamond province of Yakutia 4 YAKUT MEDICAL JOURNAL 94 Popova T.E., Tappakhov A.A., Nikolaeva T.Ya., Okoneshnikova L.T., Petrova A.Yu., Govorova T.G., Semenov A.A., Gogoleva L.N., Noeva N .N., Soktoeva Т.V. Epidemiology of Parkinson’s disease in the RS(Ya) 97 Emelyanova E.A., Safonova S.L. Dynamics of the structure of gastroenterological morbidity in patients of dispensary groups of 20– year observation 100 Baisheva A.R., Alekseeva S.N., Argunova E.F., Sukhomyasova A.L., Pavlova K.K., Nikiforova M.E., Danilova G.I., Zhelobtsova A.F. Results of neonatal screening on adrenogenital syndrome in children in the RS (Ya) for 10 years Nutrition in the North Abolyan L.V., Lebedeva U.M., Stepanov K.M., Novikova S.V. 103 Epidemiology of breastfeeding, its importance for maternal and child health, well-being and sustainable development of society: an overview of current data Actual topic Shats M.M., Skachkov Yu.B., Cherepanova A.P. 108 Street traumatism in Yakutsk as a derivative of state of road systems Scientific reviews and lectures Chakhov A.A., Ushnitsky I.D. 109 The role and importance of anatomical and topographical features of the mandible at mandibular anesthesia Point of view Egorova A.G., Romanova A.N. 110 Application of bee products in cardiology: experience, implementation problems in medical practice Clinical case 113 Gorokhova A.V., Samsonova E.V., Argunova E.F, Ivanova O.N. Alport syndrome in a 16 years old child Sidorova O.G., Zakharova A. V., Moskvina O.A., 115 Pavlova N.L., Krutikova M.L., Koryakina M.V., Suzdalova Т.S., Gotovtseva L.V., Shits I.V., Moskvitina E.N., Shvedova A.Z., Andreev A.A., Kononova S.K. Cases of prenatal diagnosis of reverse arterial perfusion syndrome in Yakutia Events chronicle 3’ 2017 5 MATERIALS OF THE SCIENTIFIC-PRACTICAL CONFERENCE WITH INTERNATIONAL PARTICIPATION «MODERN APPROACHES AND PROSPECTS OF GENETIC RESEARCH IN YAKUTIA», SEPTEMBER 7, 2017, YAKUTSK G.N. Akhmadeeva G.N., I.M. Khidiyatova, T.R. Nasibullin, A.R. Baitimerov, R.V. Magzhanov, E.K. Khusnutdinova RESEARCH OF ASSOCIATION OF POLYMORPHIC VARIANTS OF GENES DOPAMINE SYSTEM’s (DRD1, DRD2, DRD3, DRD4, TH, COMT AND MAO-B) WITH IDIOPATHIC Parkinson’s DISEASE ABSTRACT The dopamine metabolism disorder played a major role in the pathogenesis of Parkinson’s disease (PD).
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