Table 30.2. Intramammary preparations available for lactating cows in the United States.

Drug Name and Class Product Name Label Regimen and Indications Other Label Claims

Amoxicillin Amoxi-Mast 3 treatments at 12-hour intervals Susceptibility shown by E. coli in vitro Aminopenicillin (Merck Animal Health) Subclinical S. aureus mastitis Most Enterobacter, Klebsiella, and Pseudomonas resistant Subclinical S. agalactiae mastitis Ceftiofur Spectramast 2–8 treatments at 24-hour intervals third-generation cephalosporin (Zoetis) Clinical coagulase-negative Staphylococcus mastitis Clinical S. dysgalactiae mastitis Clinical E. coli mastitis Cephapirin Today, Cefa-lak 2 treatments at a 12-hour interval Shown to be efficacious against susceptible strains of first-generation cephalosporin (Fort Dodge Animal Health) Mastitis in lactating cows S. agalactiae and S. aureus Cloxacillin Dariclox 3 treatments at 12-hour intervals There is laboratory evidence that indicates cloxacillin is penicillin (penicillinase-resistant) (Merck Animal Health) resistant to destruction by penicillinase-producing organisms Clinical S. aureus mastitis (non-penicillinase producing strains) Clinical S. agalactiae mastitis 1 Erythromycin Gallimycin-36 (Agri-Labs) 3 treatments at 12-hour intervals 1Works against both acute and chronic cases macrolide 2Gallimycin®-36 (Durvet) Clinical S. aureus mastitis Clinical S. agalactiae mastitis Clinical S. dysgalactiae mastitis Clinical S. uberis mastitis Hetacillin Hetacin-K Intramammary Aminopenicillin Infusion 3 treatments at 24-hour intervals (Fort Dodge Animal Health) Acute, chronic, or subclinical mastitis ShownS. dysgalactiae, to be efficacious S. aureus in treatment of mastitis in lactating cows caused by susceptible strains of S. agalactiae, , and E. coli Penicillin Masti-Clear Not more than 3 treatments at 12-hour intervals penicillin (G.C. Hanford) Clinical S. agalactiae mastitis Clinical S. dysgalactiae mastitis Clinical S. uberis mastitis Pirlimycin Pirsue Aqueous Gel 2 treatments at a-24 hour interval Has been proven effective only against Staphylococcus Lincosamide (Zoetis) Clinical and subclinical mastitis species such as S. aureus and Streptococcus species such as S. dysgalactiae and S. uberis

Note: Although every effort has been made to ensure that the information presented here is accurate and complete, the authors cannot bear responsibility for any errors or omissions. Readers are advised to contact drug manufacturers and/or read package inserts for complete information about the products listed herein.