EPA Method 525.2
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Detection of Estrogen Receptor Endocrine Disruptor Potency of Commonly Used Organochlorine Pesticides Using the LUMI-CELL ER Bioassay
DEVELOPMENTAL AND REPRODUCTIVE TOXICITY Detection of Estrogen Receptor Endocrine Disruptor Potency of Commonly Used Organochlorine Pesticides Using The LUMI-CELL ER Bioassay John D. Gordon1, Andrew C: Chu1, Michael D. Chu2, Michael S. Denison3, George C. Clark1 1Xenobiotic Detection Systems, Inc., 1601 E. Geer St., Suite S, Durham, NC 27704, USA 2Alta Analytical Perspectives, 2714 Exchange Drive, Wilmington, NC 28405, USA 3Dept. of Environmental Toxicology, Meyer Hall, Univ. of California, Davis; Davis, CA 95616 USA Introduction Organochlorine pesticides are found in many ecosystems worldwide as result of agricultural and industrial activities and exist as complex mixtures. The use of these organochlorine pesticides has resulted in the contamination of lakes and streams, and eventually the animal and human food chain. Many of these pesticides, such as pp ’-DDT, pp ’-DDE, Kepone, Vinclozolin, and Methoxychlor (a substitute for the banned DDT), have been described as putative estrogenic endocrine disruptors, and act by mimicking endogenous estrogen 1-3 . Estrogenic compounds can have a significant detrimental effect on the endocrine and reproductive systems of both human and other animal populations 4 . Previous studies have shown a strong association between several EDCs (17p-Estradiol, DES, Zeralanol, Zeralenone, Coumestrol, Genistein, Biochanin A, Diadzein, Naringenin, Tamoxifin) and estrogenic activity via uterotropic assay, cell height, gland number, increased lactoferrin, and a transcriptional activity assay using BG1Luc4E2 cells4 . Some other examples of the effects of these EDCs are: decreased reproductive success and feminization of males in several wildlife species; increased hypospadias along with reductions in sperm counts in men; increase in the incidence of human breast and prostate cancers; and endometriosis 3-5 . -
Endocrine Disruptors
Endocrine disruptors Afke Groen & Christine Neuhold The RECIPES project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 824665 Authors Afke Groen, Maastricht University* Christine Neuhold, Maastricht University * currently works at the think tank Mr. Hans van Mierlo Stichting With thanks to our two anonymous interviewees Manuscript completed in April 2020 Document title WP2 Case study: Endocrine disruptors Work Package WP2 Document Type Deliverable Date 13 April 2020 Document Status Final version Acknowledgments & Disclaimer This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 824665. Neither the European Commission nor any person acting on behalf of the Commission is responsible for the use which might be made of the following information. The views expressed in this publication are the sole responsibility of the author and do not necessarily reflect the views of the European Commission. Reproduction and translation for non-commercial purposes are authorised, provided the source is acknowledged and the publisher is given prior notice and sent a copy. WP2 Case study: Endocrine disruptors i Abstract Endocrine disrupting chemicals (EDCs) are at the centre stage of a scientific and regulatory controversy. Given the complexities, ambiguities and particularly the uncertainties surrounding the hazards of EDCs, the precautionary principle is of utmost relevance to the case. Even the definition of EDCs remains much contested, as do the scientific processes and methods through which to identify them. On the one hand, there is considerable societal pressure to regulate ECDs ‘now’. On the other hand, this quick regulation is often impossible as the limited evidence available does not suffice in the context of traditional EU scientific risk assessment. -
1 of 3 GC+LC-USA
Updated: 07/18/2016 1 of 3 GC+LC-USA Limit of Quantitation (LOQ): 0.010 mg/kg (ppm) Sample Types: Low Fat Content Samples Minimum Sample Size: 100 grams (~1/4 pound). Certain products require more for better sample representation. Instrument: GC-MS/MS and LC-MS/MS Turnaround: 24-48 hours Accreditation: Part of AGQ USA's ISO/IEC 17025 Accreditation Scope 4,4'-Dichlorobenzophenone Bupirimate Cyantraniliprole Diflufenican Abamectin Buprofezin Cyazofamid Dimethoate Acephate Butachlor Cycloate Dimethoate (Sum) Acequinocyl Butocarboxim Cycloxydim Dimethomorph Acetamiprid Butralin Cyflufenamid Diniconazole Acetochlor Cadusafos Cyfluthrin Dinocap Acrinathrin Captafol Cymoxanil Dinotefuran Alachlor Captan Cyproconazole Diphenylamine Aldicarb Captan (Sum) Cyprodinil Disulfoton Aldicarb (Sum) Carbaryl Cyromazine Disulfoton (Sum) Aldicarb-sulfone Carbofuran DDD-o,p Disulfoton-sulfone Aldicarb-sulfoxide Carbofuran-3-hydroxy DDD-p,p +DDT-o,p Disulfoton-sulfoxide Aldrin Carbophenothion DDE-o,p Ditalimfos Ametryn Carbosulfan DDE-p,p Diuron Amitraz Carboxine DDT (Sum) Dodemorph Atrazine Carfentrazone-ethyl DDT-p,p Dodine Azadirachtin Chinomethionat DEET Emamectin Benzoate Azamethiphos Chlorantraniliprole Deltamethrin Endosulfan (A+B+Sulf) Azinphos-ethyl Chlordane Demeton Endosulfan Alfa Azinphos-methyl Chlordane Trans Demeton-S-methyl-sulfone Endosulfan Beta Azoxystrobin Chlorfenapyr Desmedipham Endosulfan Sulfate Benalaxyl Chlorfenson Diafenturion Endrin Ben-Carb-TPM (Sum) Chlorfenvinphos Dialifos EPN Bendiocarb Chlorfluazuron Diazinon Epoxiconazole -
Chemical Specific Parameters May 2019
Regional Screening Level (RSL) Chemical-specific Parameters Supporting Table April 2019 Contaminant Molecular Weight Volatility Parameters Melting Point Density Diffusivity in Air and Water Partition Coefficients Water Solubility Tapwater Dermal Parameters H` HLC H` and HLC VP VP MP MP Density Density Dia Diw Dia and Diw Kd Kd Koc Koc log Kow log Kow S S B τevent t* Kp Kp Analyte CAS No. MW MW Ref (unitless) (atm-m3/mole) Ref mmHg Ref C Ref (g/cm3) Ref (cm2/s) (cm2/s) Ref (L/kg) Ref (L/kg) Ref (unitless) Ref (mg/L) Ref (unitless) (hr/event) (hr) (cm/hr) Ref Acephate 30560-19-1 1.8E+02 PHYSPROP 2.0E-11 5.0E-13 EPI 1.7E-06 PHYSPROP 8.8E+01 PHYSPROP 1.4E+00 CRC89 3.7E-02 8.0E-06 WATER9 (U.S. EPA, 2001) 1.0E+01 EPI -8.5E-01 PHYSPROP 8.2E+05 PHYSPROP 2.1E-04 1.1E+00 2.7E+00 4.0E-05 EPI Acetaldehyde 75-07-0 4.4E+01 PHYSPROP 2.7E-03 6.7E-05 PHYSPROP 9.0E+02 PHYSPROP -1.2E+02 PHYSPROP 7.8E-01 CRC89 1.3E-01 1.4E-05 WATER9 (U.S. EPA, 2001) 1.0E+00 EPI -3.4E-01 PHYSPROP 1.0E+06 PHYSPROP 1.3E-03 1.9E-01 4.5E-01 5.3E-04 EPI Acetochlor 34256-82-1 2.7E+02 PHYSPROP 9.1E-07 2.2E-08 PHYSPROP 2.8E-05 PHYSPROP 1.1E+01 PubChem 1.1E+00 PubChem 2.2E-02 5.6E-06 WATER9 (U.S. -
EICG-Hot Spots
State of California AIR RESOURCES BOARD PUBLIC HEARING TO CONSIDER AMENDMENTS TO THE EMISSION INVENTORY CRITERIA AND GUIDELINES REPORT FOR THE AIR TOXICS “HOT SPOTS” PROGRAM STAFF REPORT: INITIAL STATEMENT OF REASONS DATE OF RELEASE: September 29, 2020 SCHEDULED FOR CONSIDERATION: November 19, 2020 Location: Please see the Public Agenda which will be posted ten days before the November 19, 2020, Board Meeting for any appropriate direction regarding a possible remote-only Board Meeting. If the meeting is to be held in person, it will be held at the California Air Resources Board, Byron Sher Auditorium, 1001 I Street, Sacramento, California 95814. This report has been reviewed by the staff of the California Air Resources Board and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Air Resources Board, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. This Page Intentionally Left Blank TABLE OF CONTENTS EXECUTIVE SUMMARY .......................................................................................... 1 I. INTRODUCTION AND BACKGROUND ................................................................. 5 II. THE PROBLEM THAT THE PROPOSAL IS INTENDED TO ADDRESS .................... 6 III. BENEFITS ANTICIPATED FROM THE REGULATORY ACTION, INCLUDING THE BENEFITS OR GOALS PROVIDED IN THE AUTHORIZING STATUTE .................... 8 IV. AIR QUALITY .......................................................................................................... -
Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure
1 Mutagens and Reproductive Toxins Chemical Class Standard Operating Procedure Mutagens and Reproductive Toxins H340 H341 H360 H361 H362 This SOP is not a substitute for hands-on training. Print a copy and insert into your laboratory SOP binder. Department: Chemistry Date SOP was written: Thursday, July 1, 2021 Date SOP was approved by PI/lab supervisor: Thursday, July 1, 2021 Name: F. Fischer Principal Investigator: Signature: ______________________________ Name: Matthew Rollings Internal Lab Safety Coordinator or Lab Manager: Lab Phone: 510.301.1058 Office Phone: 510.643.7205 Name: Felix Fischer Emergency Contact: Phone Number: 510.643.7205 Tan Hall 674, 675, 676, 679, 680, 683, 684 Location(s) covered by this SOP: Hildebrand Hall: D61, D32 1. Purpose This SOP covers the precautions and safe handling procedures for the use of Mutagens and Reproductive Toxins. For a list of Mutagens and Reproductive Toxins covered by this SOP and their use(s), see the “List of Chemicals”. Procedures described in Section 12 apply to all materials covered in this SOP. A change to the “List of Chemicals” does not constitute a change in the SOP requiring review or retraining. If you have questions concerning the applicability of any recommendation or requirement listed in this procedure, contact the Principal Investigator/Laboratory Supervisor or the campus Chemical Hygiene Officer at [email protected]. 2. Physical & Chemical Properties/Definition of Chemical Group Germ Cell Mutagenicity is a hazard class that is primarily concerned with chemicals that may cause mutations in the germ cell of humans that can be transmitted to the progeny. Rev. -
Registration Division Conventional Pesticides -Branch and Product
Registration Division Conventional Pesticides - Branch and Product Manager (PM) Assignments For a list of Branch contacts, please click the following link: http://www2.epa.gov/pesticide-contacts/contacts-office-pesticide-programs-registration-division Branch FB=Fungicide Branch. FHB=Fungicide Herbicide Branch. HB=Herbicide Branch. Abbreviations: IVB*= Invertebrate-Vertebrate Branch 1, 2 or 3. MUERB=Minor Use and Emergency Response Branch. Chemical Branch PM 1-Decanol FHB RM 20 1-Naphthaleneacetamide FHB RM 20 2, 4-D, Choline salt HB RM 23 2,4-D HB RM 23 2,4-D, 2-ethylhexyl ester HB RM 23 2,4-D, butoxyethyl ester HB RM 23 2,4-D, diethanolamine salt HB RM 23 2,4-D, dimethylamine salt HB RM 23 2,4-D, isopropyl ester HB RM 23 2,4-D, isopropylamine salt HB RM 23 2,4-D, sodium salt HB RM 23 2,4-D, triisopropanolamine salt HB RM 23 2,4-DB HB RM 23 2,4-DP HB RM 23 2,4-DP, diethanolamine salt HB RM 23 2,4-DP-p HB RM 23 2,4-DP-p, 2-ethylhexyl ester FB RM 21 2,4-DP-p, DMA salt HB RM 23 2-EEEBC FB RM 21 2-Phenylethyl propionate FHB RM 20 4-Aminopyridine IVB3 RM 07 4-Chlorophenoxyacetic acid FB RM 22 4-vinylcyclohexene diepoxide IVB3 RM 07 Abamectin IVB3 RM 07 Acephate IVB2 RM 10 Acequinocyl IVB3 RM 01 Acetaminophen IVB3 RM 07 Acetamiprid IVB3 RM 01 Acetic acid, (2,4-dichlorophenoxy)-, compd. with methanamine (1:1) HB RM 23 Acetic acid, trifluoro- FHB RM 20 Acetochlor HB RM 25 Acibenzolar-s-methyl FHB RM 24 Acid Blue 9 HB RM 23 Acid Yellow 23 HB RM 23 Sunday, June 06, 2021 Page 1 of 17 Chemical Branch PM Acifluorfen HB RM 23 Acrinathrin IVB1 RM 03 -
RECORD of APPROVED ACTIVE CONSTITUENTS This Information Is Current As at 19/02/2014
RECORD OF APPROVED ACTIVE CONSTITUENTS This information is current as at 19/02/2014 Note: Evergreen Nurture as a site of manufacture is known to be non-existent. Approvals have been restored to the Record pursuant to a Federal Court Order dated 13 October 2008. It should not be relied upon to support other products. COMMON NAME APPROVAL HOLDER MANUFACTURE SITE APPROVAL NO. Syngenta Crop Protection Schweizerhalle Ag Production Plant Muttenz Rothausstrasse 61 (S)-METHOPRENE Novartis Animal Health Australasia Pty. Limited Ch-4133 Pratteln Switzerland 44095 Wellmark International Jayhawk Fine Chemicals 8545 Southeast Jayhawk Dr (S)-METHOPRENE Wellmark International (australia) Pty Ltd Galena Ks 66739-0247 Usa 55179 Babolna Bioenvironmental Centre Ltd (S)-METHOPRENE Babolna Bioenvironmental Centre Ltd Budapest X Szallas Utca 6 Hungary 58495 Vyzkumny Ustav Organickych Syntez As Rybitvi 296 532 18 Pardubice 20 Czech (S)-METHOPRENE Vyzkumny Ustav Organickych Zyntez As Republic 59145 Synergetica-changzhou Gang Qu Bei Lu Weitang New District Changzhou Jiangsu (S)-METHOPRENE Zocor Inc 213033 Pr China 59428 1,2-ETHANEDIAMINE POLYMER WITH (CHLOROMETHYL) OXIRANE AND N- METHYLMETHANAMINE MANUFACTURING Buckman Laboratories Pty Ltd East Bomen CONCENTRATE Buckman Laboratories Pty Ltd Road Wagga Wagga Nsw 2650 56821 The Dow Chemical Company Building A-915 1,3-DICHLOROPROPENE Dow Agrosciences Australia Limited Freeport Texas 77541 Usa 52481 COMMON NAME APPROVAL HOLDER MANUFACTURE SITE APPROVAL NO. Dow Chemical G.m.b.h. Werk Stade D-2160 1,3-DICHLOROPROPENE Dow Agrosciences Australia Limited Stade Germany 52747 Agroquimicos De Levante (dalian) Company Limited 223-1 Jindong Road Jinzhou District 1,3-DICHLOROPROPENE Agroquimicos De Levante, S.a. -
Final Report
Final Report Effects of Molecular and Environmental Properties on Removal of Pharmaceuticals, Endocrine Disruptors and Disinfection Byproducts by Polyamide RO Membranes Submitted by: Orange County Water District Research & Development Group 18700 Ward Street Fountain Valley, CA Submitted to: United States Environmental Protection Agency Grant Assistance Number XP –97933101-0. Project Manager: Bruce Macler, Ph.D Metropolitan Water District of Southern California Desalination Research and Innovation Partnership Project Manager: Christopher Gabelich, Ph.D January 2008 Acknowledgement This study was made possible by the financial support of the Desalination Research and Innovation Partnership (DRIP) through funding provided by the United States Environmental Protection Agency. The Metropolitan Water District of Southern California is acknowledged for the resources it has dedicated and the commitment made to the management of the DRIP program. ii Table of Contents Executive Summary............................................................................................................ v Abstract.............................................................................................................................. xi List of Figures................................................................................................................... xii List of Tables ................................................................................................................... xiii 1.0 Introduction.................................................................................................................. -
At Least 394 Pesticides May Affect Endangered and Threatened Species
At least 394 pesticides may affect endangered and threatened species: 1,3-Dichloropropene 10,10'-Oxybisphenoxyarsine 2-(2,4-DP), dimethylamine salt 2,4-D, 2-ethylhexyl ester 2,4-D, butoxyethanol ester 2,4-D, diethanolamine salt 2,4-D, diethylamine salt 2,4-D, Dimethylamine salt 2,4-D, isooctyl ester 2,4-D, isopropyl ester 2,4-D, isopropylamine salt 2,4-D, salts and esters 2,4-D, sodium salt 2,4-D, triisopropanolamine salt 2,4-DB acid 2,4-DB, dimethylamine salt 2,4-DP-P, Dimethylamine salt 2,4-DP-P, isooctyl ester 2,4-DP, isooctyl ester 2,4-DP,2-ethylhexyl ester 3-chloro-p-toluidine hydrochloride 3-iodo-2-propynyl butyl carbamate 3-Trifluoromethyl-4-nitrophenol 4-aminopyridine Acephate Acequinocyl Acetamiprid Acetochlor Acibenzolar-S-methyl Acrolein Alachlor Aldicarb Alpha-chlorohydrin Aluminum phosphide Ametryne Aminopyralid potassium salt Aminopyralid and salts Aminopyralid, triisopropanolamine salt Amitraz Amitrole Ammonium bromide Antimycin A Arsenic acid Arsenic pentoxide Arsenic trioxide Atrazine Avermectin Azinphos-methyl Azoxystrobin Benfluralin Bensulide Bentazon and salts Bentazon, sodium salt Beta-cyfluthrin Bethoxazin Bifenazate Bifenthrin Bis-(N-cyclohexyldiazeniumdioxy)-copper Brodifacoum Bromacil and salts Bromacil, lithium salt Bromadiolone Bromethalin Bromoxynil butyrate Bromoxynil heptanoate Bromoxynil octanoate Bromoxynil, salts and esters Buprofezin Butralin Butylate Captan Carbaryl Carbendazim Carbendazim phosphate Carbofuran Carboxin Chelerythrine chloride-sanguinarine chloride mixture Chlorantraniliprole Chlorethoxyphos -
Summary of New Initiatives That May Affect Waste Management Programs
Futures Analysis of Chemicals affecting Waste Management Programs Summary of New Initiatives that may affect waste management programs Prepared for U.S. EPA Technology Innovation Office under a National Network of Environmental Management Studies Fellowship by Tiffany Portoghese Compiled May - August 2003 NOTICE This document was prepared by a National Network of Environmental Management Studies grantee under a fellowship from the U.S. Environmental Protection Agency. This report was not subject to EPA peer review or technical review. The U.S. EPA makes no warranties, expressed or implied, including without limitation, warranty for completeness, accuracy, or usefulness of the information, warranties as to the merchantability, or fitness for a particular purpose. Moreover, the listing of any technology, corporation, company, person, or facility in this report does not constitute endorsement, approval, or recommendation by the U.S. EPA. i FOREWORD Environmental concern and interest is growing for future analysis of potential environmental problems. EPA’s Technology Innovation Office (TIO) provided a grant through the National Network for Environmental Management Studies (NNEMS) to prepare a technology assessment report on a futures analysis of chemicals within the offices of the EPA and their potential effect on waste management programs. This report was prepared by a third year law student and a second year graduate student from Syracuse University in New York during the summer of 2003. It has been reproduced to help provide federal agencies, states, consulting engineering firms, private industries, and technology developers with information. About the National Network for Environmental Management Studies (NNEMS) NNEMS is a comprehensive fellowship program managed by the Environmental Education Division of EPA. -
Steroid Levels, Steroid Metabolic
Universitat Autònoma de Barcelona Programa de Doctorat de Farmacologia, Terapèutica i Toxicologia STEROID LEVELS, STEROID METABOLIC PATHWAYS AND THEIR MODULATION BY ENDOCRINE DISRUPTORS IN INVERTEBRATES Tesi doctoral Gemma Janer Gual 2005 Universitat Autònoma de Barcelona CONSELL SUPERIOR UNIVERSITAT AUTÒNOMA DE D’INVESTIGACIONS CIENTÍFIQUES BARCELONA Institut d’Investigacions Químiques i Programa de Doctorat de Farmacologia, Ambientals de Barcelona Terapèutica i Toxicologia Departament de Química Ambiental Memòria presentada per optar al títol de Doctora en Farmacologia, Terapèutica i Toxicologia per GEMMA JANER GUAL DIRECTORA: TUTOR: Cinta Porte Visa Raimon Guitart Bas Investigadora Titular d’Universitat Dept. Química Ambiental Dept. Farmacologia, Terapèutica i IIQAB-CSIC Toxicologia, UAB Aquest treball, que ha estat realitzat al departament de Química Ambiental del IIQAB- CSIC, ha estat possible gràcies a una beca predoctoral del Ministerio de Educación y Ciencia i als projectes europeus BEEP ( ENVK3-CT-2000-00025) i COMPRENDO (EVK1- CT-2002-00129). AGRAÏMENTS Si aquesta tesi ha estat possible és gràcies a la Cinta Porte, que em va donar l’oportunitat de treballar en el seu laboratori i que m’ha dirigit aquesta tesis amb constància i esperit científic. Gràcies per la confiança dipositada en mi, per haver-me escoltat sempre, per enviar-me a reunions i congressos, pel suport en el meu treball i per tot el que m’ha ensenyat. En Raimon Guitart per la tutoria d’aquest treball i per ajudar-me en els tràmits burocràtics. Als membres del tribunal per haver acceptat a formar-hi part. Als meus companys de laboratori (Rebeca, Ramón, Rémi, Denise, Angeliki, Sabine, Carlos, Itziar, Alice, Arun, i Demetrio), per la seva ajuda a la feina (tinc dos tubs per proteïnes....) i a mantenir el bon humor (happy Friday!), per la seva paciència amb mi (crec que el boli que busques el tinc jo...) i per les bones estones que hem passat dins (food!!) i fora del laboratori (otra vez salsa, no!).