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Threats to Sources of Drinking Water and Aquatic Ecosystem Health in Canada Threats to Sources of Drinking Water and Aquatic Ecosystem Health in Canada
THREATS TO SOURCES OF DRINKING WATER AND AQUATIC ECOSYSTEM HEALTH IN CANADA THREATS TO SOURCES OF DRINKING WATER AND AQUATIC ECOSYSTEM HEALTH IN CANADA NWRI Scientific Assessment Report Series No. 1 NATIONAL WATER RESEARCH INSTITUTE ENVIRONMENT CANADA © Minister of Public Works and Government Services Canada 2001 To obtain additional copies: Science Liaison Branch National Water Research Institute Environment Canada 867 Lakeshore Road, P.O. Box 5050 Burlington, ON L7R 4A6 Or download a copy in pdf format from the NWRI web site: http://www.cciw.ca/nwri/ National Library of Canada Cataloguing in Publication data Main entry under title: Threats to sources of drinking water and aquatic ecosystem health in Canada (NWRI Scientific Assessment Report Series, ISSN 1499-5905; no. 1) Issued also in French under title: Menaces pour les sources d’eau potable et les écosystèmes aquatiques au Canada. ISBN 0-662-31315-1 Cat. No. En40-237/1-2001E 1. Drinking water – – Contamination – – Canada – – Congresses. 2. Water – – Pollution – – Canada – – Congresses. 3. Water quality – – Canada – – Congresses. I. National Water Research Institute (Canada) II. Series. TD226.T47 2001 363.6’1’0971 C2001-980362-1 This report may be cited as follows: Environment Canada. 2001. Threats to Sources of Drinking Water and Aquatic Ecosystem Health in Canada. National Water Research Institute, Burlington, Ontario. NWRI Scientific Assessment Report Series No. 1. 72 p. ii Table of Contents Foreword . v Executive Summary . .. vii 1. Waterborne Pathogens . 1 2. Algal Toxins and Taste and Odour . 5 3. Pesticides . 9 4. Persistent Organic Pollutants and Mercury . 13 5. Endocrine Disrupting Substances . 17 6. Nutrients—Nitrogen and Phosphorus . -
Ranvet's Filybol
Ranvet's Filybol Ranvet Chemwatch Hazard Alert Code: 2 Chemwatch: 4787-83 Issue Date: 08/02/2016 Version No: 5.1.1.1 Print Date: 10/28/2016 Safety Data Sheet according to WHS and ADG requirements S.GHS.AUS.EN SECTION 1 IDENTIFICATION OF THE SUBSTANCE / MIXTURE AND OF THE COMPANY / UNDERTAKING Product Identifier Product name Ranvet's Filybol Chemical Name peanut oil Synonyms Not Available Other means of Not Available identification Relevant identified uses of the substance or mixture and uses advised against Relevant identified Non-virilising anabolic combination for fillies, mares, colts and stallions. uses Details of the supplier of the safety data sheet Registered company Ranvet name Address 10-12 Green Street Banksmeadow NSW 2019 Australia Telephone +61 2 9666 1744 Fax +61 2 9666 1755 Website https://www.ranvet.com.au/other_msds.htm Email [email protected] Emergency telephone number Association / Not Available Organisation Emergency telephone +61 425 061 584 numbers Other emergency Not Available telephone numbers SECTION 2 HAZARDS IDENTIFICATION Classification of the substance or mixture Poisons Schedule S4 Carcinogenicity Category 2, Reproductive Toxicity Category 2, Acute Aquatic Hazard Category 2, Chronic Aquatic Hazard Classification [1] Category 2 1. Classified by Chemwatch; 2. Classification drawn from HSIS ; 3. Classification drawn from EC Directive 1272/2008 - Annex Legend: VI Label elements GHS label elements SIGNAL WORD WARNING Continued... Chemwatch: 4787-83 Page 2 of 10 Issue Date: 08/02/2016 Version No: 5.1.1.1 Ranvet's Filybol Print Date: 10/28/2016 Hazard statement(s) H351 Suspected of causing cancer. H361 Suspected of damaging fertility or the unborn child. -
Cheminova, 2007, P.8)
Downloaded from orbit.dtu.dk on: Sep 23, 2021 Analysis of Cheminova CSR practice Jørgensen, Michael Søgaard; Milanez, Bruno; Porto, Marcelo Firpo Publication date: 2008 Document Version Early version, also known as pre-print Link back to DTU Orbit Citation (APA): Jørgensen, M. S., Milanez, B., & Porto, M. F. (2008). Analysis of Cheminova CSR practice. DTU Management and ENSP/FIOCRUZ. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Users may download and print one copy of any publication from the public portal for the purpose of private study or research. You may not further distribute the material or use it for any profit-making activity or commercial gain You may freely distribute the URL identifying the publication in the public portal If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Analysis of Cheminova CSR practice Working paper by Michael Søgaard Jørgensen, DTU Management Engineering, Technical University of Denmark Bruno Milanez, National School of Public Health – Oswaldo Cruz Foundation (ENSP/FIOCRUZ) Marcelo Firpo Porto, National School of Public Health – Oswaldo Cruz Foundation (ENSP/FIOCRUZ) Version 12 September 2008 1. Analytical approach...................................................................................................................... -
(12) United States Patent (10) Patent No.: US 9,394,315 B2 Aicher Et Al
USOO93943 15B2 (12) United States Patent (10) Patent No.: US 9,394,315 B2 Aicher et al. (45) Date of Patent: Jul.19, 2016 (54) TETRAHYDROI18NAPHTHYRIDINE 6,605,634 B2 8, 2003 Zablocki et al. SULFONAMIDE AND RELATED 6,638,960 B2 10/2003 Assmann et al. 6,683,091 B2 1/2004 Asberomet al. COMPOUNDS FOR USEAS AGONSTS OF 6,828,344 B1 12/2004 Seehra et al. RORY AND THE TREATMENT OF DISEASE 7,084, 176 B2 8, 2006 Morie et al. 7,138.401 B2 11/2006 Kasibhatla et al. (71) Applicant: Lycera Corporation, Ann Arbor, MI 7,329,675 B2 2/2008 Cox et al. 7,420,059 B2 9, 2008 O'Connor et al. (US) 7,482.342 B2 1/2009 D’Orchymont et al. 7,569,571 B2 8/2009 Dong et al. (72) Inventors: Thomas D. Aicher, Ann Arbor, MI (US); 7,696,200 B2 4/2010 Ackermann et al. Peter L. Toogood, Ann Arbor, MI (US); 7,713.996 B2 5/2010 Ackermann et al. Xiao Hu, Northville, MI (US) 7,741,495 B2 6, 2010 Liou et al. 7,799,933 B2 9/2010 Ceccarelli et al. (73) Assignee: Lycera Corporation, Ann Arbor, MI 2006,0004000 A1 1/2006 D'Orchymont et al. 2006/010O230 A1 5, 2006 Bischoff et al. (US) 2007/0010537 A1 1/2007 Hamamura et al. 2007/OO 10670 A1 1/2007 Hirata et al. (*) Notice: Subject to any disclaimer, the term of this 2007/0049556 A1 3/2007 Zhang et al. patent is extended or adjusted under 35 2007/0060567 A1 3/2007 Ackermann et al. -
Detection of Estrogen Receptor Endocrine Disruptor Potency of Commonly Used Organochlorine Pesticides Using the LUMI-CELL ER Bioassay
DEVELOPMENTAL AND REPRODUCTIVE TOXICITY Detection of Estrogen Receptor Endocrine Disruptor Potency of Commonly Used Organochlorine Pesticides Using The LUMI-CELL ER Bioassay John D. Gordon1, Andrew C: Chu1, Michael D. Chu2, Michael S. Denison3, George C. Clark1 1Xenobiotic Detection Systems, Inc., 1601 E. Geer St., Suite S, Durham, NC 27704, USA 2Alta Analytical Perspectives, 2714 Exchange Drive, Wilmington, NC 28405, USA 3Dept. of Environmental Toxicology, Meyer Hall, Univ. of California, Davis; Davis, CA 95616 USA Introduction Organochlorine pesticides are found in many ecosystems worldwide as result of agricultural and industrial activities and exist as complex mixtures. The use of these organochlorine pesticides has resulted in the contamination of lakes and streams, and eventually the animal and human food chain. Many of these pesticides, such as pp ’-DDT, pp ’-DDE, Kepone, Vinclozolin, and Methoxychlor (a substitute for the banned DDT), have been described as putative estrogenic endocrine disruptors, and act by mimicking endogenous estrogen 1-3 . Estrogenic compounds can have a significant detrimental effect on the endocrine and reproductive systems of both human and other animal populations 4 . Previous studies have shown a strong association between several EDCs (17p-Estradiol, DES, Zeralanol, Zeralenone, Coumestrol, Genistein, Biochanin A, Diadzein, Naringenin, Tamoxifin) and estrogenic activity via uterotropic assay, cell height, gland number, increased lactoferrin, and a transcriptional activity assay using BG1Luc4E2 cells4 . Some other examples of the effects of these EDCs are: decreased reproductive success and feminization of males in several wildlife species; increased hypospadias along with reductions in sperm counts in men; increase in the incidence of human breast and prostate cancers; and endometriosis 3-5 . -
Biopesticides – Expectations for Control
Biopesticides – Expectations for Control Jeanette Gaultier, Crops Knowledge Centre, Manitoba Agriculture, Food and Rural Initiatives, Carman, MB R0G 0J0 Email: [email protected] A biopesticide is a naturally occurring organism or substance that can be used to control pests. The term ‘biopesticide’ can be applied to microorganisms, biochemicals and plant extracts that are used as pest control products. Although not the case in Canada, some countries also consider plants with ‘incorporated protectants’ (i.e. transgenic crops) as biopesticides. Interest in biopesticides is increasing because such products are often recognized as ‘reduced’ or ‘low’ risk alternatives to conventional pesticides. In Canada, a pesticide is considered to be of reduced risk if human health and/or environmental risks are decreased relative to other pesticides registered for the same use. General characteristics of reduced risk pesticides include (PMRA, 2002): • Low toxicity; • Limited effects on non-target organisms; • Good environmental profile; • Low pest resistance potential; • Decreased application rates or applications; and • Compatible with integrated pest management principles. A product doesn’t have to be a biopesticide to be considered reduced risk. Conversely, biopesticides are often, but not always, classified as reduced risk. Biopesticides currently account for only a small percentage (~1%) of the global pesticide market (Copping and Menn, 2000; Warrior, 2000; Rodgers, 1993). These products have generally found commercial success in niche markets such as horticulture, greenhouse, nursery and ornamental, and organic production. Uptake and use of biopesticides in conventional field crop agriculture remains low. Why is this the case? What should agricultural producers expect from biopesticides? Regulatory Expectations All pesticides, including biopesticides, available for use in Canada are regulated by Health Canada’s Pest Management Regulatory Agency (PMRA). -
High-Throughput H295R Steroidogenesis Assay: Utility As an Alternative and a Statistical Approach to Characterize Effects on Steroidogenesis Derik E
High-throughput H295R steroidogenesis assay: utility as an alternative and a statistical approach to characterize effects on steroidogenesis Derik E. Haggard ORISE Postdoctoral Fellow National Center for Computational Toxicology Computational Toxicology Communities of Practice Dec. 14th, 2017 The views expressed in this presentation are those of the author and do not necessarily reflect the views or policies of the U.S. EPA Outline • Background • Objectives • Assay Background • Methods and Results 1. Evaluation of the HT-H295R assay 2. Development of a quantitative prioritization metric for the HT-H295R assay data • Summary and Conclusions 2 Steroid Hormone Biosynthesis & Metabolism • Proper steroidogenesis is essential: • In utero for fetal development • In adults for reproductive function • Disruption can result in congenital adrenal hyperplasia, sterility, prenatal virilization, salt wasting, etc. • >90% of steroidogenesis occurs in the gonads • Leydig cells (males) or follicular cells (females) • Adrenal gland (corticosteroids) 3 https://www.pharmacorama.com/en/Sections/Androgen_steroid_hormones.php US EPA Endocrine Disruptor Screening Program (EDSP) • EDSP mandated to screen chemicals for endocrine activity (estrogen, androgen, thyroid) • Initial tiered screen relied on low-throughput assays • Modernization of EDSP (EDSP21) to use high-throughput and computational methods • Prioritize the universe of EDSP chemicals for endocrine bioactivity • Altering hormone levels via disruption of biosynthesis or metabolism can also contribute -
Endocrine Disruptors
Endocrine disruptors Afke Groen & Christine Neuhold The RECIPES project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 824665 Authors Afke Groen, Maastricht University* Christine Neuhold, Maastricht University * currently works at the think tank Mr. Hans van Mierlo Stichting With thanks to our two anonymous interviewees Manuscript completed in April 2020 Document title WP2 Case study: Endocrine disruptors Work Package WP2 Document Type Deliverable Date 13 April 2020 Document Status Final version Acknowledgments & Disclaimer This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 824665. Neither the European Commission nor any person acting on behalf of the Commission is responsible for the use which might be made of the following information. The views expressed in this publication are the sole responsibility of the author and do not necessarily reflect the views of the European Commission. Reproduction and translation for non-commercial purposes are authorised, provided the source is acknowledged and the publisher is given prior notice and sent a copy. WP2 Case study: Endocrine disruptors i Abstract Endocrine disrupting chemicals (EDCs) are at the centre stage of a scientific and regulatory controversy. Given the complexities, ambiguities and particularly the uncertainties surrounding the hazards of EDCs, the precautionary principle is of utmost relevance to the case. Even the definition of EDCs remains much contested, as do the scientific processes and methods through which to identify them. On the one hand, there is considerable societal pressure to regulate ECDs ‘now’. On the other hand, this quick regulation is often impossible as the limited evidence available does not suffice in the context of traditional EU scientific risk assessment. -
Supplemental File 11
Supplemental File 11 Supplemental Table 11. OECD Reference Chemical Performance in HT H295R versus OECD inter-laboratory results and literature-reported results. Chemical identifiers (chemical name and casn) are provided for the 25 reference chemicals that overlapped between high-throughput (HT) H295R screening and the OECD inter-laboratory validation study (Hecker et al., 2011). Trilostane, glyphosate, and human chorionic gonadotrophin were not screened in the HT H295R assay. The adjusted maxmMd value, quadrants of the steroid synthesis pathway affected (progestagens (P), glucocorticoids (G), androgens (A), and/or estrogens (E)), and the number of steroid hormones affected using the ANOVA-based logic described in the main text are also provided. The OECD inter-laboratory results for estradiol (E2) and testosterone (T) are summarized along with a brief overview of additional information from the reported literature for activity in the H295R assay (if other in vitro assay data are referenced, the assay type is provided). Only 2 of the 25 chemicals with overlapping data were reported as negative for effects on both E2 and T: ethylene dimethanesulfonate and benomyl. NA indicates that no concentration-response screening data were available (only single concentration screening available). # Chemical identifiers Results from HT H295R assay OECD Inter-laboratory and literature-reported Chemical name casn Adjusted maxmMd Quadrants # Steroid results of steroid hormones biosynthesis affected pathway affected 1 Mifepristone 84371-65-3 27 P 2 Used pharmacologically as an abortifacient with antiprogestagen, antiglucocorticoid, and antiandrogen properties. Moderate induction of E2 (2 to 4-fold induction) and T (equivocal) synthesis (Hecker, et al., 2011). Strong modulation of glucocorticoid pathway in H295R cells as a GR antagonist (Asser et al., 2014). -
Table of Codes for Each Court of Each Level
Table of Codes for Each Court of Each Level Corresponding Type Chinese Court Region Court Name Administrative Name Code Code Area Supreme People’s Court 最高人民法院 最高法 Higher People's Court of 北京市高级人民 Beijing 京 110000 1 Beijing Municipality 法院 Municipality No. 1 Intermediate People's 北京市第一中级 京 01 2 Court of Beijing Municipality 人民法院 Shijingshan Shijingshan District People’s 北京市石景山区 京 0107 110107 District of Beijing 1 Court of Beijing Municipality 人民法院 Municipality Haidian District of Haidian District People’s 北京市海淀区人 京 0108 110108 Beijing 1 Court of Beijing Municipality 民法院 Municipality Mentougou Mentougou District People’s 北京市门头沟区 京 0109 110109 District of Beijing 1 Court of Beijing Municipality 人民法院 Municipality Changping Changping District People’s 北京市昌平区人 京 0114 110114 District of Beijing 1 Court of Beijing Municipality 民法院 Municipality Yanqing County People’s 延庆县人民法院 京 0229 110229 Yanqing County 1 Court No. 2 Intermediate People's 北京市第二中级 京 02 2 Court of Beijing Municipality 人民法院 Dongcheng Dongcheng District People’s 北京市东城区人 京 0101 110101 District of Beijing 1 Court of Beijing Municipality 民法院 Municipality Xicheng District Xicheng District People’s 北京市西城区人 京 0102 110102 of Beijing 1 Court of Beijing Municipality 民法院 Municipality Fengtai District of Fengtai District People’s 北京市丰台区人 京 0106 110106 Beijing 1 Court of Beijing Municipality 民法院 Municipality 1 Fangshan District Fangshan District People’s 北京市房山区人 京 0111 110111 of Beijing 1 Court of Beijing Municipality 民法院 Municipality Daxing District of Daxing District People’s 北京市大兴区人 京 0115 -
Glyphosate: Unsafe on Any Plate
GLYPHOSATE: UNSAFE ON ANY PLATE ALARMING LEVELS OF MONSANTO’S GLYPHOSATE FOUND IN POPULAR AMERICAN FOODS “For the first time in the history of the world, every human being is now subjected to contact with dangerous chemicals from the moment of conception until death…These chemicals are now stored in the bodies of the vast majority of human beings, regardless of age. They occur in the mother’s milk, and probably in the tissues of the unborn child.”1 —RACHEL CARSON, SILENT SPRING “Glyphosate was significantly higher in humans [fed] conventional [food] compared with predominantly organic [fed] humans. Also the glyphosate residues in urine were grouped according to the human health status. Chronically ill humans had significantly higher glyphosate residues in urine than healthy humans”2 —MONIKA KRUGER, ENVIRONMENTAL & ANALYTICAL TOXICOLOGY “Analysis of individual tissues demonstrated that bone contained the highest concentration of [14C] glyphosate equivalents (0.3–31ppm). The remaining tissues contained glyphosate equivalents at a concentration of between 0.0003 and 11 ppm. In the bone and some highly perfused tissues, levels were statistically higher in males than in females.”3 —PESTICIDE RESIDUES IN FOOD, JOINT FAO/WHO MEETING 2004 1 Rachel Carson, Silent Spring, (Houghton Mifflin, 1961), Elixirs of Death, 15-16. 2 Krüger M, Schledorn P, Schrödl W, Hoppe HW, Lutz W, et al. (2014) Detection of Glyphosate Residues in Animals and Humans. J Environ Anal Toxicol 4: 210 3 Residues in Food, 2004, Evaluations Part II, Toxicological, Joint FAO/WHO Meeting on Pesticide Residues. http://apps.who.int/iris/ bitstream/10665/43624/1/9241665203_eng.pdf Contents What Is in This Report? Findings: The first ever independent, FDA-registered laboratory food testing results for glyphosate residues in iconic American food brands finds alarming levels of glyphosate contamination and reveal the inadequacy of current food safety regulations relating to allowable pesticide residues. -
Number HS 2007 Description Applied Tariff Rate Or Preferential Tariff Rate
Applied Tariff Rate or Preferential Tariff Rate over Ex-out / Number HS 2007 Description the NMF Tariff Note Product Rate for Specification Colombia under the FTA since 2010 1 0101.10.01 Horses Ex. 2 0101.10.99 Other Ex. 3 0101.90.01 Jump or race horses Ex. 4 0101.90.02 Non pedigreed breeding horses Ex. "Horses for slaughter, when 5 0101.90.03 imported by Federally Inspected Ex. Establishment type packers." 6 0101.90.99 Other Ex. 7 0102.10.01 Pure-bred breeding animals Ex. 8 0102.90.01 Dairy cows Ex. "With pedigree or High Registrating Certificate, 9 0102.90.02 Ex. excluding those of code 0102.90.01" "Bovines for slaughter, when 10 0102.90.03 imported by Industrial de Ex. Abastos." 11 0102.90.99 Other Ex. 12 0103.10.01 Pure-bred breeding animals Ex. With pedigree or High 13 0103.91.01 Ex. Registrating Certificate. 14 0103.91.02 Peccaries Ex. 15 0103.91.99 Other Ex. With pedigree or High 16 0103.92.01 Ex. Registrating Certificate. "Weighing more than 110 kg., 17 0103.92.02 excluding those of codes Ex. 0103.92.01 and 0103.92.03." 18 0103.92.03 Peccaries Ex. 19 0103.92.99 Other Ex. With pedigree or High 20 0104.10.01 Ex. Registrating Certificate. 21 0104.10.02 For slaughter. Ex. 22 0104.10.99 Other Ex. With pedigree or High 23 0104.20.01 Ex. Registrating Certificate. 24 0104.20.99 Other Ex. When do not require food 25 0105.11.01 28% during their transportation Newly born breeding birds, with High Registrating Certificate, for 26 0105.11.02 28% imports of up to 18,000 heads per transaction.