DOCSLIB.ORG

ICRS2014 Preliminary Programme

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
ICRS2014 Preliminary Programme TH 24 ANNUAL SYMPOSIUM OF THE INTERNATIONAL CANNABINOID RESEARCH SOCIETY BAVENO ITALY JUNE 28 - JULY 3, 2014 PRELIMINARY PROGRAMME TH 24 ANNUAL SYMPOSIUM OF THE INTERNATIONAL CANNABINOID RESEARCH SOCIETY BAVENO JUNE 28 – JULY 3, 2014 ICRS Sponsors Government Sponsors National Institute on Drug Abuse Non- Profit Organization Sponsors Kang Tsou Memorial Fund 2014 Symposium on the Cannabinoids Conference Coordinators Cecilia Hillard, Ph.D. Daniela Parolaro, Ph.D. Tiziana Rubino, Ph.D. Ethan Russo, M.D. Jason Schechter, Ph.D. Programme Committee Steve Alexander, Ph.D. Tiziana Bisogno, Ph.D. Heather B Bradshaw, Ph.D. Vincenzo Di Marzo, Ph.D. Michelle Glass, Ph.D. Matthew Hill, Ph.D Mary Lynch, Ph.D. Mauro Maccarrone, Ph.D. Sean McAllister, Ph.D. Daniela Parolaro, Ph.D. Roger G. Pertwee, M.A., D.Phil., D.Sc. Julian Romero Paredes, Ph.D. Tiziana Rubino, Ph.D. Ethan Russo, M.D. Miriam Schneider, Ph.D. Michelle Sexton, N.D. Ryan Vandrey, Ph.D. Jenny Wiley, Ph.D. Committee on Awards Steve Kinsey, Ph.D., Chair Sachin Patel, M.D., Ph.D. Student Award Committee Chair Eliot Gardner, Ph.D. Mechoulam Award Committee Francis Barth, Ph.D. Benjamin Cravatt, Ph.D. Vincenzo Di Marzo, Ph.D. Cecilia Hillard, Ph.D. Allyn Howlett, Ph.D. John Huffman, Ph.D. George Kunos, M.D., Ph.D. Gerard Le Fur, Ph.D. Aron Lichtman, Ph.D. Ken Mackie, M.D. Alex Makriyannis, Ph.D. Roger Pertwee, D.Phil, D.Sc. Raj Razdan, Ph.D. Patti Reggio, Ph.D. Murielle Rinaldi- Carmona, Ph.D. 2014 ICRS Board of Directors Executive Director Cecilia Hillard, Ph.D. President Ethan Russo, M.D. President- Elect Stephen Alexander, Ph.D. Past President Jenny Wiley, Ph.D. Secretary Steve Kinsey, Ph.D. Treasurer Mary Abood, Ph.D. International Secretary Roger Pertwee, M.a., D.Phil, D.Sc. Newsletter Editor Brian Thomas, Ph.D. Student Representative Tiffany Lee Managing Director Jason Schechter, Ph.D. Registration: June 28th, 2014 (16.00 – 18.00) Welcome Reception: 18.30 – 20.00 Day 1 Sunday, June 29th 7.00 Breakfast 8.15 Welcome and Opening Remarks Oral Session 1. Cannabinoids and Pathophysiology CHAIRS: STEVE ALEXANDER AND MAURO MACCARRONE Fabio Arturo Iannotti, STUDY OF THE EXPRESSION PROFILE Enrico Mazzarella, AND PHARMACOLOGICAL ROLE OF THE Ester Pagano, CB1 RECEPTOR IN DUCHENNE 8.30 MUSCULAR DYSTROPHY (DMD) 1 Elisabetta Gazzero, MUSCLES: A NEW OPPORTUNITY TO Raffaele Capasso REINFORCE MUSCLE REPAIR AND and Vincenzo Di Marzo LOCOMOTOR ACTIVITY PALMITOYLETHANOLAMIDE IN A RAT MODEL OF OSTEOARTHRITIS: Giulia Donvito ITS ANTI-INFLAMMATORY AND 8.45 2 and Barbara Costa ANTINOCICEPTIVE EFFECTIVENESS IN COMPARISON WITH NIMESULIDE AND ACETAMINOPHEN Marie-Chantal Larose, Caroline Turcotte, MECHANISMS OF HUMAN Cyril Martin, EOSINOPHIL MIGRATION INDUCED 9.00 3 Véronique Provost, BY THE ENDOCANNABINOID Michel Laviolette 2-ARACHIDONOYL-GLYCEROL and Nicolas Flamand Irina Bronova, PERIPHERAL TARGETING OF Katalin Erdelyi, Alex CB1 CANNABINOID RECEPTORS 9.15 4 Makriyannis, Pal Pacher PROTECTS FROM RADIATION- and Evgeny Berdyshev INDUCED PULMONARY FIBROSIS Daniel J. Hermanson, ENDOCANNABINOID Shu Xu, Naoko Brown, AUGMENTATION BY SUBSTRATE- 9.30 Jeffrey Reese, SELECTIVE COX - 2 INHIBITORS: 5 Sachin Patel MECHANISM AND IN VIVO PROBE and Lawrence J. Marnett DEVELOPMENT James Brodie, THE THERAPEUTIC HANDSHAKE: 9.45 Vincenzo Di Marzo CRAFTING MEDICINES FOR 6 and Geoffrey Guy COMPLEX MALADIES 10.00 Coffee Break PROTECTIVE ROLE OF Shimon Ben-Shabat, THE CANNABINOID RECEPTOR Shiela Hauzner, 10.30 SYSTEM IN AN IN VITRO MODEL 7 Mor Cohen OF AGE-RELATED MACULAR and Elie Beit-Yannai DEGENERATION (AMD) Ariana Foinquinos, Katharina Schimmel, Jan THE CANNABINOID-1 RECEPTOR 10.45 8 Fiedler, Thomas Thum IN CARDIAC FIBROSIS and Sandor Batkai THE ENDOCANNABINOID Kevin Wilhelmsen, N-ARACHIDONOYL DOPAMINE Samira Khakpour, 11.00 (NADA) AND WIN55,212-2 MODULATE 9 Alphonso Tran THE INFLAMMATORY ACTIVATION and Judith Hellman OF HUMAN ENDOTHELIAL CELLS Tamás Bíró, Attila Oláh, NOVEL INHIBIORS OF FATTY Dóra Bodnár, Lídia ACID AMIDE HYDROLASE Ambrus, Attila G. EXERT REMARKABLE ANTI- 11.15 Szöllősi, Nikolett Vasas, 10 INFLAMMATORY EFFECTS BOTH IN Judit Szabó-Papp, Ralf VITRO IN HUMAN KERATINOCYTES Paus, Michael Soeberdt AND IN VIVO IN NC/TND MICE and Christoph Abels Saja Baraghithy, Reem Smoum, STIMULATION OF BONE MASS 11.30 Malka Attar-Namdar, BY A NOVEL METHYLATED 11 Raphael Mechoulam OLEOYL SERINE DERIVATIVE and Itai Bab 12.00 Lunch 13.00 - 15.00 Poster Session 1 P1 Presidential Plenary Speaker CANNABINOIDS REVISITED? NEW TARGETS, CHEMISTRY AND PLANT SOURCES 15.00 Giovanni Appendino, Ph.D. Professor of Organic Chemistry, Università del Piemonte Orientale Department of Pharmaceutical Sciences, Novara, Italy 16.00 Coffee Break Oral Session 2. Pain and TRPs CHAIRS: TIZIANA BISOGNO AND MARY LYNCH Jenny Wilkerson, DIACYLGLYCEROL LIPASE Sudeshna Ghosh, BETA: NEW EVIDENCE 16.30 Ku-Lung Hsu, 12 FOR INFLAMMATORY AND Benjamin F. Cravatt NEUROPATHIC PAIN RELIEF IN MICE and Aron H. Lichtman POSITIVE ALLOSTERIC Richard A. Slivicki, MODULATION OF CB1 WITH GAT211 Liting Deng, Pushkar M. SUPPRESSES PACLITAXEL-INDUCED Kulkarni, Maria Cascio, 16.45 NEUROPATHIC PAIN WHILE 13 Roger G. Pertwee, BYPASSING UNWANTED SIDE Ganesh A. Thakur and EFFECTS OF CB1 RECEPTOR Andrea G. Hohmann ACTIVATION Miren-Josune Canduela, ANATOMY AND FUNCTIONAL Juan-Luis Mendizabal- ROLE OF THE TRANSIENT RECEPTOR Zubiaga, Amanda Sierra, POTENTIAL VANILLOID TYPE 1 IN 17.00 Naiara Royo, 14 THE DENTATE GYRUS OF A Sara Peñasco, Leire KAINATE-INDUCED SEIZURES Reguero, Nagore Puente MOUSE MODEL and Pedro Grandes OVEREXPRESSION OF TRPV1 IN HEK Heather B Bradshaw, CELLS DRIVES DRAMATIC CHANGES Emma Lieshman, IN BASAL ENDOCANNABINOIDS AND 17.15 15 Jordyn M Stuart RELATED LIPIDS WHICH ARE and Mark Connor POTENTIATED WITH STIMULATION BY CAPSAICIN Oral Session 3. Developmental CHAIRS: TIZIANA RUBINO AND SARA JANE WARD Valerio Chiurchiù, ANANDAMIDE REGULATES Alessandro Leuti, MATURATION AND FUNCTION 17.30 16 Emanuela Talamonti OF HUMAN MONOCYTE-DERIVED and Mauro Maccarrone DENDRITIC CELLS LEARNING UNDER Maria Morena, Andrea STRESS DIFFERENTIALLY Peloso, Viviana Trezza, 17.45 AFFECTS CANNABINOID 17 Matthew N. Hill MODULATION OF SPATIAL and Patrizia Campolongo MEMORY RETRIEVAL IN RATS Piray Atsak, Daniela Hauer, THE ROLE OF ENDOCANNABINOID Patrizia Campolongo, SIGNALING IN MEDIATING EFFECTS 18.00 18 Gustav Schelling, OF SEVERAL STRESS SYSTEMS IN Raquel V Fornari MEMORY CONSOLIDATION and Benno Roozendaal Andrea Martella, Rosa Maria Sepe, FUNCTIONAL CHARACTERIZATION Cristoforo Silvestri, OF THE ENDOCANNABINOID SYSTEM 18.15 19 Oliana Carnevali, DURING ZEBRAFISH (DANIO RERIO) Paolo Sordino EMBRYONIC DEVELOPMENT and Vincenzo Di Marzo EFFECTS OF DELETIONS IN FAAH Emma Leishman, ON THE ENDOCANNABINOID 18.30 Ben Cornett, Ken Mackie AND WIDE-RANGING-RELATED 20 and Heather B Bradshaw LIPIDOME IN EIGHT REGIONS OF THE MOUSE BRAIN Oral Session 4. Cannabinoids and Cancer CHAIRS: TIZIANA RUBINO AND SARA JANE WARD Paula Morales, NOVEL CB2 SELECTIVE Sandra Blasco-Benito, CANNABINOID-ORTHOQUINONES María Gómez-Cañas, EFFECTIVE FOR THE TREATMENT 18.45 Pilar Goya, 21 OF TRIPLE NEGATIVE BREAST Javier Fernández-Ruiz, CANCER AND LACKING Cristina Sánchez NON-TUMOR CELL TOXICITY and Nadine Jagerovic Christopher J. Fowler, IDENTIFYING POTENTIAL Jenny Häggström, UPSTREAM REGULATORS OF 19.00 22 Mariateresa Cipriano THE ENDOCANNABINOID SYSTEM and Peter Hammarsten IN PROSTATE CANCER 19.30 Dinner Day 2 Monday, June 30th 7.00 Breakfast Oral Session 5. Cannabinoid Receptors and Signaling CHAIRS: MICHELLE GLASS AND NEPHI STELLA BETA-ARRESTIN2 APPEARS TO MEDIATE THE ACTIVITY Chris Breivogel 8.30 OF CANNABINOIDS IN FEMALE 23 and Ankita Gupta MICE IN A MANNER THAT DIFFERS FROM MALES Nilushi Karunaratne, Paul J White, Stewart SIGNALLING PROFILE OF CRIP1a: 8.45 Fabb, Meritxell Canals, G - PROTEIN ACTIVATION AND 24 Mark Connor SIGNAL TRANSDUCTION and Daniel T Malone Etienne Hebert- Chatelain, Tifany Desprez, Edgar Soria, Luigi Bellocchio, Anna Delamarre, Arnau Busquets-Garcia, Laurie MITOCHONDRIAL CANNABINOID Robin, Nagore Puente, RECEPTORS MEDIATE SPECIFIC 9.00 25 Jean-William Dupuy, EFFECTS OF CANNABINOIDS VIA Uzaskun Elezgarai, SOLUBLE ADENYLYL CYCLASE (sAC) Rodrigue Rossignol, Federico Massa, Pedro Grandes, Giovanni Bénard and Giovanni Marsicano MOLECULAR DYNAMICS STUDY OF Derek M. Shore, A CB1 ENDOGENOUS ALLOSTERIC Diane L. Lynch, 9.15 MODULATOR, LIPOXIN A4: DYNAMIC 26 Michael C. Pitman BEHAVIOR IN A LIPID BILAYER AND and Patricia H. Reggio ENTRANCE INTO THE CB1 RECEPTOR Alipi V. Naydenov, GENETIC RESCUE OF Marja Sepers, CB1 RECEPTORS ON MEDIUM Katie Swinney, SPINY NEURONS PREVENTS 9.30 27 Lynn Raymond, LOSS OF EXCITATORY STRIATAL Richard Palmiter SYNAPSES BUT NOT MOTOR and Nephi Stella PHENOTYPE IN R6/2 MICE Martin Kaczocha, FATTY ACID BINDING Matthew W. Elmes, PROTEINS (FABPS) William T. Berger, 9.45 ARE INTRACELLULAR CARRIERS 28 KwanNok Leung, FOR ∆9-TETRAHYDROCANNABINOL Iwao Ojima (THC) AND CANNABIDIOL (CBD) and Dale G. Deutsch Michelle Glass, FUNCTIONAL SELECTIVITY IN 10.00 Courtney M Breen CB1R PHARMACODYNAMICS – 29 and Mark Connor OCCUPANCY, EFFICACY AND TIME 10.15 Coffee Break Oral Session 6. Cannabis Use and Abuse Issues CHAIRS: ZIVA COOPER AND RYAN VANDREY Maju Mathew Koola, Hailey E. Turner, CANNABIS WITHDRAWAL IN 10.45 Deanna L. Kelly, Fang 30 ADULTS WITH MOOD DISORDERS Liu, Jared A. Linthicum and David A. Gorelick Zheng-Xiong Xi, Pretal Muldoon, EFFECTS OF Xiao-Fei Wang, Guo- Δ8-TETRAHYDROCANNABIVARIN 11.00 Hua Bi, M. Imad Damaj, (Δ8-THCV) ON APPETITIVE 31 Aron H. Lichtman, EFFECTS OF COCAINE Roger G. Pertwee
Load more

Recommended publications
  • Lipid Metabolic Reprogramming: Role in Melanoma Progression and Therapeutic Perspectives
    cancers Review Lipid metabolic Reprogramming: Role in Melanoma Progression and Therapeutic Perspectives 1, 1, 1 2 1 Laurence Pellerin y, Lorry Carrié y , Carine Dufau , Laurence Nieto , Bruno Ségui , 1,3 1, , 1, , Thierry Levade , Joëlle Riond * z and Nathalie Andrieu-Abadie * z 1 Centre de Recherches en Cancérologie de Toulouse, Equipe Labellisée Fondation ARC, Université Fédérale de Toulouse Midi-Pyrénées, Université Toulouse III Paul-Sabatier, Inserm 1037, 2 avenue Hubert Curien, tgrCS 53717, 31037 Toulouse CEDEX 1, France; [email protected] (L.P.); [email protected] (L.C.); [email protected] (C.D.); [email protected] (B.S.); [email protected] (T.L.) 2 Institut de Pharmacologie et de Biologie Structurale, CNRS, Université Toulouse III Paul-Sabatier, UMR 5089, 205 Route de Narbonne, 31400 Toulouse, France; [email protected] 3 Laboratoire de Biochimie Métabolique, CHU Toulouse, 31059 Toulouse, France * Correspondence: [email protected] (J.R.); [email protected] (N.A.-A.); Tel.: +33-582-7416-20 (J.R.) These authors contributed equally to this work. y These authors jointly supervised this work. z Received: 15 September 2020; Accepted: 23 October 2020; Published: 27 October 2020 Simple Summary: Melanoma is a devastating skin cancer characterized by an impressive metabolic plasticity. Melanoma cells are able to adapt to the tumor microenvironment by using a variety of fuels that contribute to tumor growth and progression. In this review, the authors summarize the contribution of the lipid metabolic network in melanoma plasticity and aggressiveness, with a particular attention to specific lipid classes such as glycerophospholipids, sphingolipids, sterols and eicosanoids.
    [Show full text]
  • Cannabinoid Receptor Cannabinoid Receptor
    Cannabinoid Receptor Cannabinoid Receptor Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol. www.MedChemExpress.com 1 Cannabinoid Receptor Antagonists, Agonists, Inhibitors, Modulators & Activators (S)-MRI-1867 (±)-Ibipinabant Cat. No.: HY-141411A ((±)-SLV319; (±)-BMS-646256) Cat. No.: HY-14791A (S)-MRI-1867 is a peripherally restricted, orally (±)-Ibipinabant ((±)-SLV319) is the racemate of bioavailable dual cannabinoid CB1 receptor and SLV319. (±)-Ibipinabant ((±)-SLV319) is a potent inducible NOS (iNOS) antagonist. (S)-MRI-1867 and selective cannabinoid-1 (CB-1) receptor ameliorates obesity-induced chronic kidney disease antagonist with an IC50 of 22 nM. (CKD). Purity: >98% Purity: 99.93% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg 2-Arachidonoylglycerol 2-Palmitoylglycerol Cat. No.: HY-W011051 (2-Palm-Gl) Cat. No.: HY-W013788 2-Arachidonoylglycerol is a second endogenous 2-Palmitoylglycerol (2-Palm-Gl), an congener of cannabinoid ligand in the central nervous system. 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119.
    [Show full text]
  • Cannabinoid Receptor-Mediated Modulation of Inhibitory Inputs to Mitral
    1 2 Cannabinoid Receptor-Mediated Modulation of Inhibitory Inputs to Mitral 3 Cells in the Main Olfactory Bulb 4 5 Ze-Jun Wang1*, Sherry Shu-Jung Hu2*, Heather B. Bradshaw3, Liqin Sun1, Ken Mackie3, 6 Alex Straiker3, and Thomas Heinbockel1 7 8 1Department of Anatomy, Howard University College of Medicine, Washington, DC 20059, USA; 9 2Department of Psychology, National Cheng Kung University, Tainan 701, Taiwan; 3The Gill 10 Center for Biomolecular Science and the Department of Psychological and Brain Sciences, 11 Indiana University, Bloomington, IN 47405, USA 12 13 Author contributions: Z.W., S.H., A.S., and T.H. designed research; Z.W., S.H., H.B., L.S., K.M., 14 A.S., and T.H. performed research; Z.W., S.H., K.M., A.S., and T.H. analyzed data; Z.W., S.H., 15 A.S. and T.H. wrote the paper. 16 17 *Z.W. and S.H. contributed to this work to a comparable extent. 18 19 Running head: Cannabinoid Receptor-Mediated Modulation of Mitral Cells 20 21 Contact Information: 22 Thomas Heinbockel, Dept. of Anatomy, Howard University College of Medicine, 520 ‘W’ Street, 23 NW, Washington, DC 20059; tel.: (202) 806-9873; fax: (202) 265-7055; email: 24 [email protected] 25 Downloaded from www.physiology.org/journal/jn at American Univ of Beirut (193.188.128.021) on June 20, 2019. 2 26 Non-standard abbreviations: Δ9-THC, Δ9-tetrahydrocannabinol; 2-AG, 2-arachidonoyl glycerol; 27 ABHD4/6/12, α/β-hydrolase domain 4/6/12; anandamide or AEA, N-arachidonoyl ethanolamine; 28 CB1 and CB2, cannabinoid receptor 1 and 2; DGLα/β, diacylglycerol lipase α and β;
    [Show full text]
  • University of Dundee MASTER of SCIENCE Novel Modulators Of
    University of Dundee MASTER OF SCIENCE Novel Modulators of Human Sperm Motility King, Louise Award date: 2014 Link to publication General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Download date: 26. Sep. 2021 MASTER OF SCIENCE Novel Modulators of Human Sperm Motility Louise King 2014 University of Dundee Conditions for Use and Duplication Copyright of this work belongs to the author unless otherwise identified in the body of the thesis. It is permitted to use and duplicate this work only for personal and non-commercial research, study or criticism/review. You must obtain prior written consent from the author for any other use. Any quotation from this thesis must be acknowledged using the normal academic conventions. It is not permitted to supply the whole or part of this thesis to any other person or to post the same on any website or other online location without the prior written consent of the author.
    [Show full text]
  • Dehydroabietylamine Based on the Current Information A
    Health Canada Santé Canada STATUS DECISION OF CONTROLLED AND NON-CONTROLLED SUBSTANCE(S) Substance: Dehydroabietylamine Based on the current information available to the Office of Controlled Substances, it appears that the above substance is: Controlled ☐ Not Controlled X under the schedules of the Controlled Drugs and Substances Act (CDSA) for the following reason(s): There are no reports that the substance is an efficacious cannabinoid receptor agonist and therefore it cannot be included under item 1 of Schedule II to the CDSA. Prepared by: _______________________________________ Date: _______________ Zack Li Verified by: _______________________________________ Date: ________________ Mark Kozlowski Approved by: _______________________________________ Date: ________________ DIRECTOR, OFFICE OF CONTROLLED SUBSTANCES This status was requested by: “third party information removed as per agreement with applicant” 2 Drug Status Report Drug: Dehydroabietylamine Drug Name Status: Dehydroabietylamine is the common name. Chemical Name: 1-Phenanthrenemethanamine, 1,2,3,4,4a,9,10,10a-octahydro- 1,4a-dimethyl-7-(1-methylethyl)-, (1R,4aS,10aR)- Other Names: leelamine; Amine D; 13-isopropylpodocarpa-8,11,13-trien-15-amine; podocarpa- 8,11,13-trien-15-amine, 13-isopropyl- Chemical structure: Molecular Formula: C20H31N CAS-RN: 1446-61-3 Pharmacological class / Application: Synthetic cannabinoid International status: US: Dehydroabietylamine is not listed specifically in the Schedules to the US Controlled Substances Act and is not mentioned anywhere on the DEA website. United Nations: The substance is not listed on the Yellow List - List of Narcotic Drugs under International Control, the Green List - List of Psychotropic Substances under International Control, nor the Red List - List of Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances under International Control.
    [Show full text]
  • 140.Pdf (5.917Mb)
    A thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy Ibegbu, A. 2009. The effects of Hypoxia on neuronal cell signalling. PhD thesis. Queen Margaret University. Accessed from: http://etheses.qmu.ac.uk/140/ Repository Use Policy The full-text may be used and/or reproduced, and given to third parties for personal research or study, educational or not-for-profit purposes providing that: • The full-text is not changed in any way • A full bibliographic reference is made • A hyperlink is given to the original metadata page in eResearch eResearch policies on access and re-use can be viewed on our Policies page: http://eresearch.qmu.ac.uk/policies.html http://etheses.qmu.ac.uk THE EFFECTS OF HYPOXIA ON NEURONAL CELL SIGNALLING AUGUSTINE IBEGBU A thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy QUEEN MARGARET UNIVERSITY 2009 Table of Contents Contents Page No Title page i Table of contents ii-ix List of figures x-xiii List of plates xiv-xv List of tables xvi-xvii List of abbreviations and definition of terms xviii-xxii List of appendices xxiii-xxiv Declaration xxv Acknowledgements xxvi Abstract xxvii-xxix 1. CHAPTER ONE: Introduction 1 1.1. General Introduction 1-4 1.2. Signalling Overview 4-7 1.2.1. Neuronal cell signalling 8-10 1.2.2. Mechanism of signalling 10-12 1.2.3. Influence of membrane lipid on signalling 12-14 1.3. Receptors 15-17 1.3.1 G proteins 17-20 1.3.2.
    [Show full text]
  • Catalog Update01 - EU Update 31/01/2013 08:12 Page 1
    Catalog Update01 - EU_Update 31/01/2013 08:12 Page 1 Catalog update High purity biochemical tools for life scientists •Receptor agonists and antagonists •Ion channel modulators •Enzyme modulators •Signaling tools € - March 2013 Discover more at www.abcam.com/biochemicals Catalog Update01 - EU_Update 31/01/2013 08:12 Page 2 Contents Receptors & Transporters Page Receptors & Transporters (continued) Page Adenosine & Purinergics Peptide Receptors 17 P1 5 Prostanoid 18 P2 5 Serotonin Adrenoceptors 5 5-HT1 18 Cannabinoid 6 5-HT2 19 Catalytic Receptors 7 5-HT3 19 Chemokine 7 5-HT4 19 Dopamine 7 5-HT5 19 Enzyme-Linked Receptors 9 5-HT6 20 G protein-coupled estrogen 10 5-HT7 20 GABA Non-selective 20 GABAA 10 Transporters 20 GABAB 10 Sigma 20 Non-selective 10 Smoothened 20 Other 11 Sphingosine 1-Phosphate Receptors 21 Transporters 11 TGR5 21 Glutamate Toll-Like Receptors 21 AMPA & Kainate 11 Transporters 21 Broad spectrum / non-selective 11 mGlu: General 12 Ion Channels Page mGlu: Group I 12 Calcium 22 mGlu: Group I & II 12 Chloride 22 mGlu: Group II 12 Cyclic nucleotide-gated 22 mGlu: Group III 13 Ionophores, indicators & chelators 22 NMDA: AP-2 binding site 13 Other 22 NMDA: Glutamate Site 13 Potassium 22 NMDA: Glycine Site 13 Sodium 23 NMDA: Ion Channel Site 13 TRP 23 NMDA: Polyamine Site 14 Transporters 14 Enzymes Page Glycine 14 ATPase & GTPase 23 Histamine 14 Caspase 24 Imidazoline 15 Cholinesterase 24 Melatonin 15 Coenzymes 24 Muscarinic 15 Cyclase 24 Nicotinic 15 Cyclooxygenase 24 Nuclear Receptors 16 Cytochrome P450 25 Opioids 16 Deacetylase
    [Show full text]
  • PRODUCT INFORMATION Bio-Active Lipid I Screening Library (96-Well) Item No
    PRODUCT INFORMATION Bio-Active Lipid I Screening Library (96-Well) Item No. 10506 • Batch No. 0608063 Panels are routinely re-evaluated to include new catalog introductions as the research evolves. Page 1 of 35 Plate Well Contents Item Number 1 A1 Unused 1 A2 Prostaglandin A1 10010 1 A3 1-Arachidonoyl Lysophosphatidic Acid 10019 (ammonium salt) 1 A4 POV-PC 10031 1 A5 N-(α-Linolenoyl) Tyrosine 10032 1 A6 10-Nitrolinoleate 10037 1 A7 PGPC 10044 12,14 1 A8 15-deoxy-Δ -Prostaglandin A1 10065 1 A9 15-epi Prostaglandin A1 10070 1 A10 16,16-dimethyl Prostaglandin A1 10080 1 A11 N-Oleoyl Dopamine 10115 1 A12 Unused 1 B1 Unused 1 B2 Prostaglandin F2α-1-glyceryl ester 10139 1 B3 Prostaglandin E2-1-glyceryl ester 10140 1 B4 N-Arachidonoyl-3-hydroxy-γ-Aminobutyric Acid 10158 1 B5 Arachidonoyl p-Nitroaniline 10168 1 B6 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC 10172 1 B7 Arachidonoyl Ethanolamide Phosphate 10180 1 B8 Prostaglandin D2 serinol amide 10192 1 B9 Prostaglandin E2 serinol amide 10193 1 B10 Prostaglandin F2α serinol amide 10194 1 B11 Prostaglandin A2 10210 1 B12 Unused 1 C1 Unused 1 C2 13,14-dihydro-15-keto Prostaglandin A2 10260 12,14 1 C3 15-deoxy-Δ -Prostaglandin A2 10265 1 C4 16,16-dimethyl Prostaglandin A2 10280 1 C5 16-phenoxy tetranor Prostaglandin A2 10285 1 C6 17-phenyl trinor Prostaglandin A2 10288 1 C7 17-phenyl trinor-13,14-dihydro Prostaglandin A2 10290 1 C8 7-hydroxycoumarinyl-γ-Linolenate 10556 1 C9 CAY10631 10562 1 C10 Heneicosapentaenoic Acid 10670 1 C11 (±)-Jasmonic Acid-Isoleucine 10740 1 C12 Unused WARNING CAYMAN CHEMICAL THIS PRODUCT IS FOR RESEARCH ONLY - NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
    [Show full text]
  • The Galway Neuroscience Centre's Christmas Research Day 2018
    The Galway Neuroscience Centre’s Christmas Research Day 2018 th (14 Dec, HBB, from 9 am) Spot prize for the best (i.e. worst!) Xmas jumper! Galway Neuroscience Centre’s Christmas Research Day Friday 14th December 2018 9:00 Arrival 9:15 Dr Dara Cannon Meeting opening Dr Kathy Ruddy, TCD A different state of mind; Regulating motor cortical excitability 9:30 NSI Early Career Researcher 2018 using TMS-based neurofeedback Dr Sarah Roche, UCC 10:00 Progesterone: A promising treatment for inherited blinding disease NSI Early Career Runner-Up 2018 10:30 Coffee & Poster Judging Prof Colm McDonald 11:00 A Clinical Overview of Psychotic Illness Discipline Enrico Bagnoli The effect of DOPAL on the bioenergetic performances of primary 11:30 CÚRAM olfactory bulb mixed cultures James Britton Developing a Bioink to 3D printing nerve guidance conduits to 11:35 CÚRAM promote nerve regeneration Silvia Cabre The potential of multi-modal collagen hydrogels for Parkinson’s 11:40 Pharmacology disease Joan Fitzgerald 11:45 Investigating the genetics of cognitive resilience in healthy ageing Biochemistry Mairead Flynn SDCCAG8 is a schizophrenia risk gene that is required for efficient 11:50 Biochemistry primary ciliogenesis Differential effects of optogenetic modulation of rat anterior Sarah Jarrin 11:55 cingulate cortical glutamatergic neurons on the affective and Pharmacology sensory components of pain Investigation of the effects of pre-operative administration of Orlaith Mannion 12:00 FAAH inhibitors in a rat model of post-operative pain following Pharmacology
    [Show full text]
  • A Brief Overview of the Antitumoral Actions of Leelamine
    biomedicines Review A Brief Overview of the Antitumoral Actions of Leelamine Myriam Merarchi 1,2 , Young Yun Jung 3, Lu Fan 2, Gautam Sethi 2,* and Kwang Seok Ahn 3,* 1 Faculty of Pharmacy, University of Paris Descartes, 75006 Paris, France 2 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore 3 College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea * Correspondence: [email protected] (G.S.); [email protected] (K.S.A.) Received: 18 June 2019; Accepted: 15 July 2019; Published: 19 July 2019 Abstract: For the last couple of decades, natural products, either applied singly or in conjunction with other cancer therapies including chemotherapy and radiotherapy, have allowed us to combat different types of human cancers through the inhibition of their initiation and progression. The principal sources of these useful compounds are isolated from plants that were described in traditional medicines for their curative potential. Leelamine, derived from the bark of pine trees, was previously reported as having a weak agonistic effect on cannabinoid receptors and limited inhibitory effects on pyruvate dehydrogenase kinases (PDKs). It has been reported to possess a strong lysosomotropic property; this feature enables its assembly inside the acidic compartments within a cell, such as lysosomes, which may eventually hinder endocytosis. In this review, we briefly highlight the varied antineoplastic actions of leelamine that have found implications in pharmacological research, and the numerous intracellular targets affected by this agent that can effectively negate the oncogenic process. Keywords: leelamine; malignancies; molecular mechanisms, preclinical models 1.
    [Show full text]
  • Natural Phytochemicals Derived from Gymnosperms in the Prevention and Treatment of Cancers
    International Journal of Molecular Sciences Review Natural Phytochemicals Derived from Gymnosperms in the Prevention and Treatment of Cancers Tayyebeh Ghaffari 1,2 , Joo-Hyun Hong 3, Solmaz Asnaashari 4, Safar Farajnia 1, Abbas Delazar 5, Hamed Hamishehkar 1,* and Ki Hyun Kim 3,* 1 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 15731, Iran; [email protected] (T.G.); [email protected] (S.F.) 2 Student Research Committee, Tabriz University of Medical Sciences, Tabriz 15731, Iran 3 School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea; [email protected] 4 Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 15731, Iran; [email protected] 5 Research Center for Evidence based Medicine, Tabriz University of Medical Sciences, Tabriz 15731, Iran; [email protected] * Correspondence: [email protected] (H.H.); [email protected] (K.H.K.); Tel.: +98-41-3363311 (H.H.); +82-31-290-7700 (K.H.K.) Abstract: The incidence of various types of cancer is increasing globally. To reduce the critical side effects of cancer chemotherapy, naturally derived compounds have been considered for cancer treatment. Gymnosperms are a group of plants found worldwide that have traditionally been used for therapeutic applications. Paclitaxel is a commercially available anticancer drug derived from gymnosperms. Other natural compounds with anticancer activities, such as pinostrobin and pinocembrin, are extracted from pine heartwood, and pycnogenol and enzogenol from pine bark. Citation: Ghaffari, T.; Hong, J.-H.; Gymnosperms have great potential for further study for the discovery of new anticancer compounds. Asnaashari, S.; Farajnia, S.; Delazar, This review aims to provide a rational understanding and the latest developments in potential A.; Hamishehkar, H.; Kim, K.H.
    [Show full text]
  • Cannabinoid Receptor Ligands
    Cannabinoid Receptor Ligands Roger G Pertwee School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK. Phone: + 44 (0)1224 555740, Fax: + 44 (0)1224 555844, E-mail: [email protected] Roger Pertwee is currently Professor of Neuropharmacology at the University of Aberdeen and Director of Pharmacology for GW Pharmaceuticals. His research focuses on the pharmacology of cannabis and its constituents and of cannabinoid receptors and cannabis-derived, synthetic and endogenous ligands for these receptors. The Endocannabinoid System including immune cells. CB2 receptors are located predominantly in immune cells both within and Two types of cannabinoid receptor have so far been outside the central nervous system, the functions identified.1,2 These are the CB receptor, cloned 1 of these receptors including modulation of cytokine in 1990,3 and the CB receptor, cloned in 1993,4 2 release and of immune cell migration. In the brain, both of which are members of the superfamily of CB receptors are expressed by microglia,7 by blood G-protein-coupled receptors. The cloning of these 2 vessels,7 and by some neurons.8,9 However, the role receptors prompted the development of mice from of neuronal CB2 receptors is currently unknown. which cannabinoid CB1 and/or CB2 receptors have been genetically deleted and these transgenic The central distribution pattern of CB1 receptors is animals, particularly CB1 knockout mice, are now heterogeneous and accounts for several prominent widely used to explore the physiological and pharmacological properties of CB1 receptor agonists, pathological functions of cannabinoid receptors.1,5,6 for example their ability to impair cognition and CB1 receptors are found mainly at the terminals of memory and to alter the control of motor function.
    [Show full text]