TH 24 ANNUAL SYMPOSIUM OF THE

INTERNATIONAL RESEARCH SOCIETY

BAVENO

ITALY

JUNE 28 - JULY 3, 2014

PRELIMINARY PROGRAMME

TH 24 ANNUAL

SYMPOSIUM OF THE

INTERNATIONAL CANNABINOID RESEARCH SOCIETY

BAVENO

JUNE 28 – JULY 3, 2014

ICRS Sponsors

Government Sponsors

National Institute on Drug Abuse

Non- Profit Organization Sponsors

Kang Tsou Memorial Fund

2014 Symposium on the

Conference Coordinators

Cecilia Hillard, Ph.D. Daniela Parolaro, Ph.D. Tiziana Rubino, Ph.D. Ethan Russo, M.D. Jason Schechter, Ph.D.

Programme Committee

Steve Alexander, Ph.D. Tiziana Bisogno, Ph.D. Heather B Bradshaw, Ph.D. Vincenzo Di Marzo, Ph.D. Michelle Glass, Ph.D. Matthew Hill, Ph.D Mary Lynch, Ph.D. Mauro Maccarrone, Ph.D. . Sean McAllister, Ph.D. Daniela Parolaro, Ph.D. Roger G. Pertwee, M.A., D.Phil., D.Sc. Julian Romero Paredes, Ph.D. Tiziana Rubino, Ph.D. Ethan Russo, M.D. Miriam Schneider, Ph.D. Michelle Sexton, N.D. Ryan Vandrey, Ph.D. Jenny Wiley, Ph.D.

Committee on Awards

Steve Kinsey, Ph.D., Chair Sachin Patel, M.D., Ph.D.

Student Award Committee Chair

Eliot Gardner, Ph.D.

Mechoulam Award Committee

Francis Barth, Ph.D. Benjamin Cravatt, Ph.D. Vincenzo Di Marzo, Ph.D. Cecilia Hillard, Ph.D. Allyn Howlett, Ph.D. John Huffman, Ph.D. George Kunos, M.D., Ph.D. Gerard Le Fur, Ph.D. Aron Lichtman, Ph.D. Ken Mackie, M.D. Alex Makriyannis, Ph.D. Roger Pertwee, D.Phil, D.Sc. Raj Razdan, Ph.D. Patti Reggio, Ph.D. Murielle Rinaldi- Carmona, Ph.D.

2014 ICRS Board of Directors

Executive Director Cecilia Hillard, Ph.D.

President Ethan Russo, M.D.

President- Elect Stephen Alexander, Ph.D.

Past President Jenny Wiley, Ph.D.

Secretary Steve Kinsey, Ph.D.

Treasurer Mary Abood, Ph.D.

International Secretary Roger Pertwee, M.a., D.Phil, D.Sc.

Newsletter Editor Brian Thomas, Ph.D.

Student Representative Tiffany Lee

Managing Director Jason Schechter, Ph.D.

Registration: June 28th, 2014 (16.00 – 18.00)

Welcome Reception: 18.30 – 20.00

Day 1 Sunday, June 29th

7.00 Breakfast

8.15 Welcome and Opening Remarks

Oral Session 1. Cannabinoids and Pathophysiology

CHAIRS: STEVE ALEXANDER AND MAURO MACCARRONE

Fabio Arturo Iannotti, STUDY OF THE EXPRESSION PROFILE Enrico Mazzarella, AND PHARMACOLOGICAL ROLE OF THE Ester Pagano, CB1 IN DUCHENNE 8.30 MUSCULAR DYSTROPHY (DMD) 1 Elisabetta Gazzero, MUSCLES: A NEW OPPORTUNITY TO Raffaele Capasso REINFORCE MUSCLE REPAIR AND and Vincenzo Di Marzo LOCOMOTOR ACTIVITY

PALMITOYLETHANOLAMIDE IN A RAT MODEL OF OSTEOARTHRITIS: Giulia Donvito ITS ANTI-INFLAMMATORY AND 8.45 2 and Barbara Costa ANTINOCICEPTIVE EFFECTIVENESS IN COMPARISON WITH NIMESULIDE AND ACETAMINOPHEN

Marie-Chantal Larose, Caroline Turcotte, MECHANISMS OF HUMAN Cyril Martin, EOSINOPHIL MIGRATION INDUCED 9.00 3 Véronique Provost, BY THE ENDOCANNABINOID Michel Laviolette 2-ARACHIDONOYL-GLYCEROL and Nicolas Flamand

Irina Bronova, PERIPHERAL TARGETING OF Katalin Erdelyi, Alex CB1 CANNABINOID RECEPTORS 9.15 4 Makriyannis, Pal Pacher PROTECTS FROM RADIATION- and Evgeny Berdyshev INDUCED PULMONARY FIBROSIS

Daniel J. Hermanson, ENDOCANNABINOID Shu Xu, Naoko Brown, AUGMENTATION BY SUBSTRATE- 9.30 Jeffrey Reese, SELECTIVE COX - 2 INHIBITORS: 5 Sachin Patel MECHANISM AND IN VIVO PROBE and Lawrence J. Marnett DEVELOPMENT

James Brodie, THE THERAPEUTIC HANDSHAKE: 9.45 Vincenzo Di Marzo CRAFTING MEDICINES FOR 6 and Geoffrey Guy COMPLEX MALADIES

10.00 Coffee Break

PROTECTIVE ROLE OF Shimon Ben-Shabat, THE Shiela Hauzner, 10.30 SYSTEM IN AN IN VITRO MODEL 7 Mor Cohen OF AGE-RELATED MACULAR and Elie Beit-Yannai DEGENERATION (AMD)

Ariana Foinquinos, Katharina Schimmel, Jan THE CANNABINOID-1 RECEPTOR 10.45 8 Fiedler, Thomas Thum IN CARDIAC FIBROSIS and Sandor Batkai

THE ENDOCANNABINOID Kevin Wilhelmsen, N-ARACHIDONOYL DOPAMINE Samira Khakpour, 11.00 (NADA) AND WIN55,212-2 MODULATE 9 Alphonso Tran THE INFLAMMATORY ACTIVATION and Judith Hellman OF HUMAN ENDOTHELIAL CELLS

Tamás Bíró, Attila Oláh, NOVEL INHIBIORS OF FATTY Dóra Bodnár, Lídia ACID AMIDE HYDROLASE Ambrus, Attila G. EXERT REMARKABLE ANTI- 11.15 Szöllősi, Nikolett Vasas, 10 INFLAMMATORY EFFECTS BOTH IN Judit Szabó-Papp, Ralf VITRO IN HUMAN KERATINOCYTES Paus, Michael Soeberdt AND IN VIVO IN NC/TND MICE and Christoph Abels

Saja Baraghithy, Reem Smoum, STIMULATION OF BONE MASS 11.30 Malka Attar-Namdar, BY A NOVEL METHYLATED 11 Raphael Mechoulam OLEOYL SERINE DERIVATIVE and Itai Bab

12.00 Lunch

13.00 - 15.00 Poster Session 1 P1

Presidential Plenary Speaker

CANNABINOIDS REVISITED? NEW TARGETS, CHEMISTRY AND PLANT SOURCES

15.00 Giovanni Appendino, Ph.D. Professor of Organic Chemistry, Università del Piemonte Orientale Department of Pharmaceutical Sciences, Novara, Italy

16.00 Coffee Break

Oral Session 2. Pain and TRPs

CHAIRS: TIZIANA BISOGNO AND MARY LYNCH

Jenny Wilkerson, DIACYLGLYCEROL LIPASE Sudeshna Ghosh, BETA: NEW EVIDENCE 16.30 Ku-Lung Hsu, 12 FOR INFLAMMATORY AND Benjamin F. Cravatt NEUROPATHIC PAIN RELIEF IN MICE and Aron H. Lichtman

POSITIVE ALLOSTERIC Richard A. Slivicki, MODULATION OF CB1 WITH GAT211 Liting Deng, Pushkar M. SUPPRESSES PACLITAXEL-INDUCED Kulkarni, Maria Cascio, 16.45 NEUROPATHIC PAIN WHILE 13 Roger G. Pertwee, BYPASSING UNWANTED SIDE Ganesh A. Thakur and EFFECTS OF CB1 RECEPTOR Andrea G. Hohmann ACTIVATION

Miren-Josune Canduela, ANATOMY AND FUNCTIONAL Juan-Luis Mendizabal- ROLE OF THE TRANSIENT RECEPTOR Zubiaga, Amanda Sierra, POTENTIAL VANILLOID TYPE 1 IN 17.00 Naiara Royo, 14 THE DENTATE GYRUS OF A Sara Peñasco, Leire KAINATE-INDUCED SEIZURES Reguero, Nagore Puente MOUSE MODEL and Pedro Grandes

OVEREXPRESSION OF TRPV1 IN HEK Heather B Bradshaw, CELLS DRIVES DRAMATIC CHANGES Emma Lieshman, IN BASAL ENDOCANNABINOIDS AND 17.15 15 Jordyn M Stuart RELATED LIPIDS WHICH ARE and Mark Connor POTENTIATED WITH STIMULATION BY CAPSAICIN

Oral Session 3. Developmental

CHAIRS: TIZIANA RUBINO AND SARA JANE WARD

Valerio Chiurchiù, REGULATES Alessandro Leuti, MATURATION AND FUNCTION 17.30 16 Emanuela Talamonti OF HUMAN MONOCYTE-DERIVED and Mauro Maccarrone DENDRITIC CELLS

LEARNING UNDER Maria Morena, Andrea STRESS DIFFERENTIALLY Peloso, Viviana Trezza, 17.45 AFFECTS CANNABINOID 17 Matthew N. Hill MODULATION OF SPATIAL and Patrizia Campolongo MEMORY RETRIEVAL IN RATS

Piray Atsak, Daniela Hauer, THE ROLE OF ENDOCANNABINOID Patrizia Campolongo, SIGNALING IN MEDIATING EFFECTS 18.00 18 Gustav Schelling, OF SEVERAL STRESS SYSTEMS IN Raquel V Fornari MEMORY CONSOLIDATION and Benno Roozendaal

Andrea Martella, Rosa Maria Sepe, FUNCTIONAL CHARACTERIZATION Cristoforo Silvestri, OF THE 18.15 19 Oliana Carnevali, DURING ZEBRAFISH (DANIO RERIO) Paolo Sordino EMBRYONIC DEVELOPMENT and Vincenzo Di Marzo

EFFECTS OF DELETIONS IN FAAH Emma Leishman, ON THE ENDOCANNABINOID 18.30 Ben Cornett, Ken Mackie AND WIDE-RANGING-RELATED 20 and Heather B Bradshaw LIPIDOME IN EIGHT REGIONS OF THE MOUSE BRAIN

Oral Session 4. Cannabinoids and Cancer

CHAIRS: TIZIANA RUBINO AND SARA JANE WARD

Paula Morales, NOVEL CB2 SELECTIVE Sandra Blasco-Benito, CANNABINOID-ORTHOQUINONES María Gómez-Cañas, EFFECTIVE FOR THE TREATMENT 18.45 Pilar Goya, 21 OF TRIPLE NEGATIVE BREAST Javier Fernández-Ruiz, CANCER AND LACKING Cristina Sánchez NON-TUMOR CELL TOXICITY and Nadine Jagerovic

Christopher J. Fowler, IDENTIFYING POTENTIAL Jenny Häggström, UPSTREAM REGULATORS OF 19.00 22 Mariateresa Cipriano THE ENDOCANNABINOID SYSTEM and Peter Hammarsten IN PROSTATE CANCER

19.30 Dinner

Day 2 Monday, June 30th

7.00 Breakfast

Oral Session 5. Cannabinoid Receptors and Signaling

CHAIRS: MICHELLE GLASS AND NEPHI STELLA

BETA-ARRESTIN2 APPEARS TO MEDIATE THE ACTIVITY Chris Breivogel 8.30 OF CANNABINOIDS IN FEMALE 23 and Ankita Gupta MICE IN A MANNER THAT DIFFERS FROM MALES

Nilushi Karunaratne, Paul J White, Stewart SIGNALLING PROFILE OF CRIP1a: 8.45 Fabb, Meritxell Canals, G - PROTEIN ACTIVATION AND 24 Mark Connor SIGNAL TRANSDUCTION and Daniel T Malone

Etienne Hebert- Chatelain, Tifany Desprez, Edgar Soria, Luigi Bellocchio, Anna Delamarre, Arnau Busquets-Garcia, Laurie MITOCHONDRIAL CANNABINOID Robin, Nagore Puente, RECEPTORS MEDIATE SPECIFIC 9.00 25 Jean-William Dupuy, EFFECTS OF CANNABINOIDS VIA Uzaskun Elezgarai, SOLUBLE ADENYLYL CYCLASE (sAC) Rodrigue Rossignol, Federico Massa, Pedro Grandes, Giovanni Bénard and Giovanni Marsicano

MOLECULAR DYNAMICS STUDY OF Derek M. Shore, A CB1 ENDOGENOUS ALLOSTERIC Diane L. Lynch, 9.15 MODULATOR, LIPOXIN A4: DYNAMIC 26 Michael C. Pitman BEHAVIOR IN A LIPID BILAYER AND and Patricia H. Reggio ENTRANCE INTO THE CB1 RECEPTOR

Alipi V. Naydenov, GENETIC RESCUE OF Marja Sepers, CB1 RECEPTORS ON MEDIUM Katie Swinney, SPINY NEURONS PREVENTS 9.30 27 Lynn Raymond, LOSS OF EXCITATORY STRIATAL Richard Palmiter SYNAPSES BUT NOT MOTOR and Nephi Stella PHENOTYPE IN R6/2 MICE

Martin Kaczocha, FATTY ACID BINDING Matthew W. Elmes, PROTEINS (FABPS) William T. Berger, 9.45 ARE INTRACELLULAR CARRIERS 28 KwanNok Leung, FOR ∆9- Iwao Ojima (THC) AND (CBD) and Dale G. Deutsch

Michelle Glass, FUNCTIONAL SELECTIVITY IN 10.00 Courtney M Breen CB1R PHARMACODYNAMICS – 29 and Mark Connor OCCUPANCY, EFFICACY AND TIME

10.15 Coffee Break

Oral Session 6. Use and Abuse Issues

CHAIRS: ZIVA COOPER AND RYAN VANDREY

Maju Mathew Koola, Hailey E. Turner, CANNABIS WITHDRAWAL IN 10.45 Deanna L. Kelly, Fang 30 ADULTS WITH MOOD DISORDERS Liu, Jared A. Linthicum and David A. Gorelick

Zheng-Xiong Xi, Pretal Muldoon, EFFECTS OF Xiao-Fei Wang, Guo- Δ8- 11.00 Hua Bi, M. Imad Damaj, (Δ8-THCV) ON APPETITIVE 31 Aron H. Lichtman, EFFECTS OF COCAINE Roger G. Pertwee AND NICOTINE IN RODENTS and Eliot L. Gardner

Ryan Vandrey, Edward J EFFECT OF ROOM VENTILATION ON Cone, John M. Mitchell, THE PHARMACODYNAMIC AND Evan S. Herrmann, 11.15 PHARMACOKINETIC EFFECTS OF 32 George E. Bigelow, SECONDHAND CANNABIS SMOKE Charles LoDico EXPOSURE and Ron Flegel

ADVERSE PEER-EXPERIENCES Miriam Schneider, THROUGHOUT ADOLESCENCE Chris M. Friemel, IN MALE RATS PERSISTENTLY 11.30 33 Laura Bindila ALTER ETHANOL INTAKE AND and Beat Lutz ENDOCANNABINOID SIGNALING IN LATER LIFE

NALTREXONE MAINTENANCE M. Haney, G. Bedi REDUCES CANNABIS 11.45 34 and Z.D. Cooper SELF-ADMINISTRATION IN CANNABIS SMOKERS

12.00 Lunch

12.30 NIDA Career InfoSession

Oral Session 6 (Cont.) Cannabis Use and Abuse Issues

CHAIRS: ZIVA COOPER AND RYAN VANDREY

Antonia Manduca, SOCIAL REWARD IS MEDIATED Patrizia Campolongo, BY INTERACTING OPIOID AND Louk J.M.J. 14.00 CB1 CANNABINOID RECEPTORS 35 Vanderschuren, IN THE NUCLEUS ACCUMBENS Olivier J. Manzoni CORE IN ADOLESCENT RATS and Viviana Trezza

Daniel Ziemianski, Rielle Capler, CANNABIS IN MEDICINE: A Rory Tekanoff, NATIONAL EDUCATIONAL NEEDS 14.15 36 Anais Lacasse, ASSESSMENT AMONG CANADIAN Francesca Luconi PHYSICIANS and Mark A. Ware

Jordyn Stuart, ACTIVITY OF SYNTHETIC Samuel D. Banister, CANNABINOID DRUGS OF ABUSE Courtney Breen, 14.30 AT G PROTEIN COUPLED CB 37 Michelle Glass, RECEPTORS AND CANNABINOID- Michael Kassiou SENSITIVE ION CHANNEL and Mark Connor

EFFECTS OF CANNABIS ON THE Ziva D. Cooper, SUBJECTIVE-EFFECT RATINGS 14.45 Richard W. Foltin 38 AND PHARMACOKINETICS and Margaret Haney OF SMOKED COCAINE

Philippe Lucas, Zachary Walsh, Kim Crosby, SUBSTITUTION EFFECT IN 628 Robert Callaway, Lynne, MEDICAL CANNABIS PATIENTS; Belle-Isle, Rielle Capler, 15.00 RESULTS FROM THE CANNABIS 39 Susan Holtzman, Bob ACCESS FOR MEDICAL PURPOSES Kay, Jamie Marshall, SURVEY (CAMPS) Trevor Stratton and Michael Woodsworth

15.15 Coffee Break

Oral Session 7. Metabolism

CHAIRS: RANGAN MAITRA AND JENNY WILEY

Livio Luongo, Luigia LEPTIN-CONTROLLED Cristino, Roberta OREXIN/ENDOCANNABINOID Imperatore, Serena INTERACTIONS IN THE MOUSE Boccella, Stefania 15.45 PERIAQUEDUCTAL GREY: ROLE IN 40 Petrosino, Francesca THE REGULATION OF THE Guida, Piero Orlando, DESCENDING ANTINOCICEPTIVE Vincenzo Di Marzo PATHWAY and Sabatino Maione

IN VIVO EVALUATION OF THE Rangan Maitra, Alan PERIPHERALLY SELECTIVE CB1 Fulp, Herbert Seltzman, 16.00 RECEPTOR ANTAGONIST RTI-13329- 41 Yanan Zhang 2 IN A MOUSE MODEL OF DIET- and Timothy Fennell INDUCED WEIGHT GAIN

Natalia Murataeva, WHERE’S MY ENTOURAGE? THE 16.15 Alex Straiker 42 CURIOUS CASE OF 2-OG AND 2-LG and Ken Mackie

Emma Leishman, NAPE-PLD DELETION VIA AN Ben Cornett, ALTERNATIVE MECHANISM 16.30 43 Ken Mackie and DRIVES SIGNIFICANT DECREASES Heather B Bradshaw IN AEA IN THE MOUSE BRAIN

Oral Session 8. CNS and Psychiatric Issues

CHAIRS: MATT HILL AND DANIELA PAROLARO

Rebecca J. Bluett, Brian Shonesy, Daniel Hermanson, Nolan BIDIRECTIONAL MANIPULATIONS Hartley, Teniel Ramikie, OF 2-ARACHIDONOYLGLYCEROL 16.45 44 Lawrence Marnett, CONTENT MODULATE ANXIETY- Danny Winder, LIKE BEHAVIORS Roger Colbran and Sachin Patel

Zach Walsh, CANNABIS, ANXIETY, AND PAIN: Kim Crosby, 17.00 THE IMPORTANCE OF COPING 45 Kelsey Lozenski STYLE and Susan Holtzman

17.15 Snack Break

Luciana Leo, Suellen ENDOGENOUS CB1 Almeida-Corrêa, Claudio ALLOSTERIC ENHANCER 17.45 Canetti, Olavo Amaral, 46 BALANCES AGE-RELATED Fernando Bozza COGNITIVE ALTERATIONS and Fabricio Pamplona

Andras Bilkei-Gorzo, Onder Albayram, Anastasia Piyanova, Mona Dvir-Ginzberg, Δ9-THC RESTORES AGE-RELATED 18.00 47 Astrid Draffehn, CHANGES IN THE BRAIN Itai Bab, Joachim Schultze, Ildiko Racz and Andreas Zimmer

Arnau Busquets-Garcia, Maria Gomis-González, Laura Cutando, Raj K. A PERIPHERAL Srivastava, Antonio ENDOCANNABINOID MECHANISM 18.15 Ortega-Álvaro, Luigi 48 Bellochio, Giovanni FOR STRESS-INDUCED AMNESIA Marsicano, Beat Lutz, Rafael Maldonado and Andrés Ozaita

PERSISTENT MICROGLIA ACTIVATION WITHIN THE Erica Zamberletti, PREFRONTAL CORTEX Marina Gabaglio, CONTRIBUTES TO THE 18.30 Pamela Prini, DEVELOPMENT OF THE 49 Tiziana Rubino DEPRESSIVE/PSYCHOTIC- and Daniela Parolaro LIKE PHENOTYPE INDUCED BY ADOLESCENT THC EXPOSURE IN RATS

A MEDICAL ETHNOGRAPHIC Michelle Sexton REPORT OF CANNABIS USE IN 18.45 50 and Dominic Corva PEDIATRIC INTRACTABLE EPILEPSY (IE) PATIENTS

19.00 Dinner - On Your Own

Day 3 Tuesday, July 1st

7.00 Breakfast

NIDA Symposium

TRP Channels: The only TR(i)P you can have on cannabinoids?

CHAIR: VINCENZO DI MARZO

ANATOMY AND FUNCTIONAL ROLE Pedro Grandes OF THE TRANSIENT RECEPTOR 8.15 Medicine and Dentistry POTENTIAL VANILLOID TYPE 1 IN N1 Basque Country University THE DENTATE GYRUS OF A KAINATE- Leioa, Spain INDUCED SEIZURES MOUSE MODEL

Thomas Voets MODULATION OF TEMPERATURE- 8.45 Laboratory of Ion Channel N2 Research (LICR) SENSITIVE TRP CHANNELS Leuven, Belgium

INTERACTIONS BETWEEN Vincenzo Di Marzo THE "ENDOCANNABINOIDOME" Endocannabinoid Research Group 9.15 Institute of Biomolecular Chemistry AND THE "TRPOME": A NEW "OME" N3 Consiglio Nazionale delle Ricerche FOR PHYTOCANNABINOIDS Pozzuoli, Italy AND LIPID MEDIATORS?

9.45 Coffee Break

Oral Session 9. Cannabinoid Genetics

CHAIRS: JAHAN MARCU AND ROGER PERTWEE

Kevin J. McKernan, Amir Zare, Lei Zhang, Jessica Spangler, EXOME SEQUENCING OF FAMILIAL Vasisht Tadigotla, Ted ATRIAL FIBRILLATION INFORMS 10.15 51 Foss, Christine Stanley, POSITIVE TREATMENT WITH Melissa Pulliam, CANNABIDIOL Robert W. Pulliam and Richard G. Boles

Mauro Maccarrone, Andrea Di Francesco, EPIGENETIC REGULATION OF Bernardo Dell´Osso, THE ENDOCANNABINOID SYSTEM 10.30 52 Daniela Galimberti, IN HUMAN PSYCHIATRIC A. Carlo Altamura DISORDERS and Claudio D´Addario

J.M. van Gool, GENETIC DIFFERENCES IN THE 10.45 I. Heitland, L. Groenink CB1/CNR1 GENE MODULATE FEAR 53 and J.M.P. Baas EXTINCTION IN HUMANS

A QUESTION OF RANK: John M. McPartland USING DNA BARCODES TO 11.00 54 and Geoffrey W. Guy CLASSIFY CANNABIS SATIVA AND CANNABIS INDICA

Special ICRS Speaker

OPTOGENETIC APPROACHES TO STUDYING 11.15 REWARD AND SUBSTANCE ABUSE DISORDERS

Antonello Bonci, Ph.D. National Institutes of Health

12.15 Lunch

13.15 - 15.00 Poster Session 2 P2

15.00 - OUTING

Notes:

Day 4 Wednesday, July 2nd

7.00 Breakfast

Luigia Cristino, OREXIN/ENDOCANNABINOID/ 8.15 Giovanna Morello, LEPTIN INTERACTION AFFECTS Roberta Imperatore, HYPOTHALAMIC TAU Due to 55 Fabiana Piscitelli, PHOSPHORILATION BY GLYCOGEN scheduling conflict Letizia Palomba SYNTHASE KINASE-3BETA and Vincenzo Di Marzo ACTIVATION

Oral Session 10. Focus on CB2

CHAIRS: JOSÉE GUINDON AND ANDREAS ZIMMER

Anne-Caroline Schmöle, CANNABINOID RECEPTOR 2 Ramona Göhrs, Önder DEFICIENCY ALTERS Albayram, Daniele Bano, 8.30 NEUROINFLAMMATION IN AN 56 Pierluigi Nicotera, ALZHEIMER’S DISEASE MOUSE Judith Alferink MODEL and Andreas Zimmer

SELECTIVE ACTIVATION OF Ming Gao, CB2Rs ELIMINATES VTA 8.45 Zhengxiong Xi 57 DOPAMINE NEURONAL and Jie Wu BURSTING FIRING IN RODENTS

Liting Deng, CHRONIC CANNABINOID CB2 Josée Guindon, AGONIST REVERSES PACLITAXEL Benjamin L. Cornett, 9.00 NEUROPATHY WITHOUT 58 Alexandros Makriyannis, TOLERANCE, CB1-MEDIATED Ken Mackie WITHDRAWAL OR SIDE EFFECTS and Andrea G. Hohmann

THE COMBINATION OF Josée Guindon, Liting AMITRIPTYLINE WITH FAAH OR MGL Deng, Emma Leishman, 9.15 INHIBITORS IN CHEMOTHERAPY- 59 Heather B. Bradshaw INDUCED PERIPHERAL NEUROPATHY and Andrea G. Hohmann IS CB2 MEDIATED

TAMOXIFEN IS AN ALLOSTERIC Pritesh Kumar 9.30 MODULATOR OF THE CB2 60 and Zhao-Hui Song CANNABINOID RECEPTOR

Shaojuan Zhang, Pin Shao, Ningyang Jia, Qin Tong, Xiang-qun TARGETING CB2 RECEPTOR AS A 9.45 Xie, Christina Bagia, 61 NEW PHOTOTHERAPY APPROACH Jelena M. Janjic, Ying Ding and Mingfeng Bai

10.00 Coffee Break

Oral Session 10 (cont). Focus on CB2

CHAIRS: JOSÉE GUINDON AND ANDREAS ZIMMER

Vanessa Petrucci, PEPTIDE ENDOCANNABINOIDS Andrea Chicca, Juan (PEPCANS) ARE PAMs OF CB2 10.30 62 Manuel Viveros-Paredes RECEPTORS AND INVOLVED IN THE and Jürg Gertsch INNATE IMMUNE RESPONSE

Eef L. Theunissen, Pim Heckman, Elizabeth B. de Sousa Fernandes Perna, Kim P. C. REVERSING THC-INDUCED 10.45 Kuypers, Anke Sambeth, IMPAIRMENT OF VERBAL MEMORY 63 Arjan Blokland, IN HEALTHY HUMANS Jos Prickaerts, Stefan W. Toennes and Johannes G. Ramaekers

Slava Rom, SELECTIVE STIMULATION OF Holly Dykstra, CANNABIOID TYPE 2 RECEPTORS Nancy Reichenbach, (CB2) IN MONOCYTES PREVENTS 11.00 64 Viviana Zuluaga- THEIR ENGAGEMENT OF BRAIN Ramirez ENDOTHELIUM PROTECTING BLOOD and Yuri Persidsky BRAIN BARRIER

Jenny L. Wiley, Brian F. CB2 AGONISTS: 11.15 Thomas, Hongfang Yang 65 HOW SELECTIVE ARE THEY? and Anu Mahadevan

Mario van der Stelt, Partha Mukhopadhyay, Marc Baggelaar, Zongxian Cao, Katalin PERIPHERALLY RESTRICTED, Erdelyi, Filomena Fezza, SELECTIVE CANNABINOID CB2 11.30 Bogna Ignatowska- RECEPTOR AGONIST LEI-101 66 Jankowska, Marc Ruben, PREVENTS CISPLATIN-INDUCED Resat Cinnar, George NEPHROPATHY Kunos, Aron Lichtman, Mauro Maccarrone and Pal Pacher

Jean-Michel Adam, Christian M. Apfel, Stefanie Bendels, Caterina Bissantz, Jürgen Fingerle, Ivan Formentini, Jürgen Funk, Uwe Grether, Sabine TRIAZOLOPYRIMIDINES – Grüner, Atsushi A NOVEL CLASS OF HIGHLY POTENT, 11.45 67 Kimbara, Matthias HIGHLY SELECTIVE AND IN VIVO Nettekoven, Giorgio ACTIVE CB2 AGONISTS Ottaviani, Camille Perret, Mark Rogers- Evans, Stephan Röver, Franz Schuler, Tanja Schulz-Gasch and Christoph Ullmer

12.00 Lunch

13.00 – 15.00 Poster Session 3 P3

Oral Session 11. Beyond THC: Cannabidiol and Other Components

CHAIRS: LUCIANO DE PETROCELLIS AND MICHELLE SEXTON

Attila Oláh, Lídia Ambrus, “WEED AGAINST ZIT?” – Attila G. Szöllősi, EXPLORATION OF THE MECHANISMS 15.00 68 Christos C. Zouboulis, OF THE COMPLEX ANTI-ACNE Ralf Paus ACTIONS OF CANNABIDIOL and Tamás Bíró

Jeffrey C. Raber, Sytze Elzinga, Mark E. Raber, CANNABINOID AND TERPENOID Bradley J. Douglass, 15.15 PROFILING OF CANNABIS IN 69 Cameron Miller, Aaron CALIFORNIA AND WASHINGTON Kendziorek, Justin Fischedick and Dale Gieringer

Richard C. Kevin, “SMELLS LIKE GOOD WEED”: THC David J. Allsop, LEVELS IN CANNABIS MAY BE 15.30 70 Wendy Swift PREDICTED BY MONOTERPENE and Iain S. McGregor HEADSPACE CONCENTRATIONS

Sándor Bátkai, PROTECTIVE EFFECT OF THE Partha Mukhopadhyay, PHYTOCANNABINOID BETA- 15.45 Katalin Erdélyi, 71 IN LIVER Jürg Gertsch ISCHEMIA REPERFUSION INJURY and Pál Pacher

Alex Naftaly, EFFECT OF BETA-CARYOPHYLLENE Ester Fride (Z”L), 16.00 ON PHENCYCLIDINE-INDUCED 72 Jürg Gertsch BEHAVIOURAL CHANGES and Sharon Anavi-Goffer

CANNABIDIOL PROVIDES Douglas E Brenneman, PROTECTION FROM ETHANOL 16.15 Dean Petkanas AND AMMONIUM TOXICITY 73 and William A. Kinney IN A HIPPOCAMPAL MODEL OF HEPATIC ENCEPHALOPATHY

Andrea Chicca, Diego

Caprioglio, Alberto NATURAL PRODUCT-DERIVED Minassi, Vanessa CANNABMIMETICS AS SOURCE OF 16.30 Petrucci, Salome Gachet, 74 POLYPHARMACOLOGY IN THE Giovanni Appendino, ENDOCANNABINOID SYSTEM Orazio Taglialatela-

Scafati and Jurg Gertsch

Alline Campos, CANNABIDIOL REPEATED Aline Miranda, Fatima TREATMENT INCREASES SURVIVAL 16.45 Brant, Fabiana Machado, AND PROMOTES RESCUE OF 75 Francisco Guimaraes COGNITIVE FUNCTION IN A MURINE and Antonio Teixeira MODEL OF CEREBRAL MALARIA

Maria Ceprian, Maria CANNABIDIOL PROMOTES Ruth Pazos, Federica OLIGODENDROCYTE SURVIVAL 17.00 Penna, Laura Jimenez- 76 AFTER HYPOXIA-ISCHEMIA IN Sanchez, Martin Santos NEWBORN RATS and Jose Martinez

Nadia Solowij, Erika van Hell, Samantha Broyd, Lisa-marie Greenwood, EFFECTS OF CBD ALONE AND IN 17.15 Jelena Novakovic, COMBINATION WITH THC ON 77 Camilla Beale, COGNITIVE PERFORMANCE Dave Martelozzo, Arno Hazekamp and Rodney Croft

Laura Jimenez-Sanchez, Ruth Pazos, ROLE OF 5HT1A RECEPTORS ON Hector Lafuente, Lorena THE NEUROPROTECTIVE AND Barata, Maria Ceprian, 17.30 NEUROBEHAVIORAL EFFECTS OF 78 Martin Santos, CANNABIDIOL IN HYPOXIC- Francisco Jose Alvarez ISCHEMIC NEWBORN PIGS and Jose Martinez- Orgado

THE ANXIOLYTIC-LIKE EFFECT OF CANNABIDIOL ADMINISTRATION IN Manoela V. Fogaça, CHRONICALLY STRESSED MICE IS 17.45 Alline C. Campos and MEDIATED BY THE 79 Francisco S. Guimarães ENDOCANNABINOID SYSTEM: INVOLVEMENT OF NEUROGENESIS AND AUTOPHAGY

RESULTS FROM AUDITING MEDICAL 18.00 Jahan P. Marcu CANNABIS FACILITIES IN THE 80 UNITED STATES IN 2014

18.15 ICRS BUSINESS MEETING

20.00 ICRS BANQUET

POSTER SESSION 1: TOPICS A - E DAY 1, SUNDAY, JUNE 29th: 13:00 - 15:00

TOPIC A. Cannabinoids and Pathophysiology

Michiel Balvers, Pim Koelink, Aletta Kraneveld, THE N-3 N-ACYLETHANOLAMIDE DHEA Mieke Poland, IMPROVES MANIFESTATIONS OF P1-1 Jocelijn Meijerink EXPERIMENTAL MURINE COLITIS and Renger Witkamp

THE ENDOCANNABINOID SYSTEM IS Valerio Chiurchiù, Emanuela A NOVEL MODULATOR OF HUMAN Talamonti, Alessandro Leuti P1-2 MACROPHAGE PLASTICITY AND and Mauro Maccarrone POLARIZATION

Caroline Turcotte, Simona Zarini, Stéphanie Jean, Cyril PROSTAGLANDIN D2-GLYCEROL Martin, Véronique Provost, AND E2-GLYCEROL INHIBIT HUMAN P1-3 Adam Uzieblo, Robert C NEUTROPHIL FUNCTIONS Murphy and Nicolas Flamand

EVIDENCE THAT THE NOVEL Mark Jones, Marie Smith, ENDOCANNABINOID Susan Anderson INCREASES OSTEOBLAST P1-4 and Saoirse E. O’Sullivan PROLIFERATION: A ROLE FOR CB2 AND GPR55

THE EFFECT OF CANNABINOIDS ON Valerie CM Shang, David A HUMAN BRONCHIAL EPITHELIAL CELL P1-5 Kendall and Richard E Roberts PERMEABILITY

Ku-Lung Hsu, Katsunori Tsuboi, Alexander Adibekian, Holly Pugh, Kim Masuda, INACTIVATION OF DIACYLGLYCEROL Sudeshna Ghosh, Manuel P1-6 LIPASE IN INFLAMMATORY DISEASE Sanchez-Alavez, Aron Lichtman, Bruno Conti and Benjamin F. Cravatt

DOCOSAHEXAENOYL-SEROTONIN Jocelijn Meijerink, (DHA-5-HT), AN INTESTINAL Zheng Wang, Mieke Poland, CONJUGATE OF SEROTONIN P1-7 Jean-Paul ten Klooster AND DHA EXHIBITS ANTI- and Renger Witkamp INFLAMMATORY PROPERTIES

Michael M. McDonald, THE DEVELOPMENT OF A Amos Matsiko, Adolfo López CANNABINOID-CONTAINING Noriega, Hugo D. Kieran, COLLAGEN-GAG SCAFFOLD FOR P1-8 Aoife Gowran, Kevin J. USE IN ORTHOPAEDIC TISSUE Mulhall, Fergal J. O’Brien ENGINEERING STRATEGIES and Veronica A. Campbell

Valerio Chiurchiù, Emanuela ENDOCANNABINOIDS DIFFERENTIALLY Talamonti, Mirko Lanuti MODULATE NLRP3 INFLAMMASOME P1-9 Tiziana Bisogno ACTIVATION IN PRIMARY HUMAN and Mauro Maccarrone MACROPHAGES

Michel Laviolette, Marie- METABOLISM OF EXOGENOUS Chantal Larose, Caroline ARACHIDONOYL-ETHANOLAMIDE Turcotte, Véronique Provost, P1-10 AND 2-ARACHIDONOYL-GLYCEROL Cyril Martin, Catherine Laprise BY HUMAN EOSINOPHILS and Nicolas Flamand

INFLUENCE OF THE DOPAMINE Amina M. Bagher, Robert B. RECEPTOR TYPE 2 (D2) ANTAGONIST Laprairie, Melanie E.M. Kelly P1-11 ON THE CANNABINOID RECEPTOR and Eileen M. Denovan-Wright TYPE 1 (CB1) FUNCTION

Attila Oláh, Nóra Czakó, EFFECTS OF CONTROLLED, TRANSIENT Levente Molnár, Stefania HYPEROXIA ON THE SERUM LEVELS OF Petrosino, Teresa Aveta, P1-12 DIFFERENT ENDOCANNABINOIDS – Vincenzo Di Marzo, Béla A HUMAN PILOT STUDY Fülesdi and Tamás Bíró

THE PERIPHERALLY-RESTRICTED Herbert H. Seltzman, Yatendra CANNABINOID RECEPTOR AGONIST P1-13 Mulpuri and Igor Spigelman PRNMI ALLEVIATES CISPLATIN INDUCED PERIPHERAL NEUROPATHY

OLEOYLETHANOLAMIDE (OEA) AND Mustafa Karwad, (PEA) Karen L. Wright, Michael MODULATE INTESTINAL P1-14 Larvin, Jonathan Lund PERMEABILITY IN AN IN VITRO and Saoirse E. O’Sullivan ISCHAEMIA/REPERFUSION MODEL

Ya Wang, Pierluigi Plastina, N-ACYLDOPAMINES DERIVED FROM Michiel Balvers, Mieke Poland, POLYUNSATURATED OMEGA-3 FATTY Bartolo Gabriele, Jean-Paul P1-15 ACIDS EXERT ANTI-INFLAMMATORY Vincken, Renger Witkamp EFFECTS IN MOUSE MACROPHAGES and Jocelijn Meijerink

RATIONALE FOR TARGETING THE Natalia Malek, Katarzyna ENDOCANNABINOID SYSTEM Popiolek-Barczyk, Joanna TO MANAGE NEUROINFLAMMATION P1-16 Mika, Barbara Przewlocka IN LPS-ACTIVATED PRIMARY and Katarzyna Starowicz MICROGLIAL CULTURES

Haley A. Vecchiarelli, Catherine M. Keenan, J. Megan COLITIS ALTERS CENTRAL Gray, Mohammad Bashashati, P1-17 ENDOCANNABINOID CONTENT Keith A. Sharkey and Matthew N. Hill

Ulrike Taschler, Martina MONOGLYCERIDE LIPASE DEFICIENCY Schweiger, Martin A. Storr, CAUSES INTESTINAL CANNABINOID P1-18 Rudolf Schicho RECEPTOR DESENSITIZATION and Robert Zimmermann

Elizabeth A. Cairns, Michele L. Archibald, Alex J. MODIFYING CB1 RECEPTOR Straiker, Pushkar M. Kulkarni, SIGNALLING TO REDUCE P1-19 Ganesh A.Thakur, IOP IN A MOUSE MODEL OF William H. Badridge OCULAR HYPERTENSION and Melanie E.M. Kelly

TOPIC B. Pain and TRPs

DIRECT ADMINISTRATION OF N- Bright N Okine, Manish K. PALMITOYLETHANOLAMIDE INTO THE Madasu, Fiona McGowan, RAT MEDIAL PREFRONTAL CORTEX P1-20 Brendan Harhen, Michelle REDUCES FORMALIN-EVOKED Roche and David P. Finn NOCICEPTIVE BEHAVIOUR VIA A CB1 RECEPTOR-MEDIATED MECHANISM

Mireille Alhouayek, Baptiste COMPARISON OF THE EFFECTS Buisseret, Owein Guillemot- OF INHIBITION OF ABHD6 P1-21 Legris and Giulio G. Muccioli AND MAGL ON INFLAMMATION

Samira Khakpour, Kevin INVESTIGATION OF THE ROLE Wilhelmsen, Alphonso Tran OF THE TRPV1 CHANNEL IN P1-22 and Judith Hellman ENDOTHELIAL INFLAMMATION

Martin Kaczocha, Syed Azim, ENDOCANNABINOID LEVELS James Nicholson, AND FUNCTIONAL DISABILITY Mario J. Rebecchi, STATUS IN PATIENTS WITH P1-23 William Galbavy, Tian Feng PAINFUL OSTEOARTHRITIS and Helene Benveniste

William Notcutt, Cheryl Phillips, Phillipe A RETROSPECTIVE DESCRIPTION Lacoux, Adrian Shanks, OF THE USE OF P1-24 Viji Vijayakulasingam IN UK CLINICAL PRACTICE and Laura Baldock

Pierluigi Plastina, HYDROXYTYROSYL OLEATE, AN ESTER Mieke Poland, Jocelijn ANALOGUE OF OLEOYLDOPAMINE P1-25 Meijerink, Bartolo Gabriele (OLDA), SHOWS ANTI-INFLAMMATORY and Renger Witkamp PROPERTIES IN VITRO

Molly S. Crowe, ATTENUATING NEUROPATHIC PAIN Emma Leishman, Ramesh THROUGH DUAL INHIBITION OF Gujjar, Anu Mahadevan, P1-26 CYCLOOXYGENASE AND Matthew Banks, Heather Bradshaw and Steven G. Kinsey

ANANDAMIDE MEDIATES Iryna Khasabova, Cutler THE ANTIHYPERALGESIC EFFECT Lewandowski, Xu Yao, Justin OF 2AG IN A MURINE MODEL OF P1-27 Paz, Natalya Burlakova, Donald CHEMOTHERAPY-INDUCED Simone and Virginia Seybold NEUROPATHY

THE MONOACYGLYCEROL LIPASE Sara R. Nass INHIBITOR JZL184 ATTENUATES P1-28 and Steven G. Kinsey HYPERALGESIA INDUCED BY COLLAGEN-INDUCED ARTHRITIS

LONG-TERM SOCIAL REJECTION Peggy Schneider, Laura DURING ADOLESCENCE ALTERS Bindila, Beat Lutz, Rainer PAIN PERCEPTION AND AFFECTS P1-29 Spanagel and Miriam Schneider THE ENDOCANNABINOID SYSTEM IN ADULT FEMALE RATS

Luciano De Petrocellis, “ENTOURAGE” EFFECTS OF Stefania Petrosino, Aniello PALMITOYLETHANOLAMIDE: Schiano Moriello, Santiago ENHANCEMENT OF 2-AG ACTION P1-30 Cerrato, Mariella Fusco, AT TRPV1 CHANNELS AND OF 2-AG Anna Puigdemont LEVELS IN VITRO AND IN VIVO and Vincenzo Di Marzo

ANTI-INFLAMMATORY EFFECTS OF THE CB1/CB2 AGONIST WIN55212,2 Torsten Lowin, ARE DEPENDENT ON TRPV1, TRPA1 Angelika Gräber P1-31 AND AMPK IN RHEUMATOID ARTHRITIS and Rainer H. Straub AND OSTEOARTHRITIS SYNOVIAL FIBROBLASTS

DIFFERENTIAL EFFECTS OF PHARMACOLOGICAL MODULATION Manish K. Madasu, OF TRPV1 IN THE LATERAL Bright N. Okine, Weredeselam PERIAQUEDUCTAL GREY ON P1-32 M. Olango, Michelle Roche FORMALIN-EVOKED NOCICEPTIVE and David P. Finn BEHAVIOUR IN SPRAGUE-DAWLEY AND WISTAR-KYOTO RATS

Carmen La Porta, Simona ROLE OF CB1 AND CB2 CANNABINOID Andreea Bura, Antoni Pastor, RECEPTORS IN THE EMOTIONAL AND Rafael de la Torre, Francisco P1-33 COGNITIVE ALTERATIONS ASSOCIATED Navarrete, Jorge Manzanares WITH OSTEOARTHRITIS PAIN and Rafael Maldonado

TOPIC C. Developmental

AGE OF EXPOSURE AFFECTS BEHAVIORAL RESPONSE TO Lindsay Silva, Rita Black DELTA-9-TETRAHYDROCANNABINOL P1-34 and Diana Dow-Edwards DURING THE PERI-PUBERTAL PERIOD IN THE RAT

Justine Renard, Michael LONG-TERM EFFECTS OF ADOLESCENT Loureiro, Walter J. Rushlow THC EXPOSURE ON ADULTHOOD P1-35 and Steven R. Laviolette PSYCHOPATHOLOGY

Marcoita T. Gilbert, A MOUSE MODEL SHOWS SYNTHETIC Scott E. Parnell, Eric W. Fish, CANNABINOID TERATOGENICITY P1-36 Lorinda K. Baker AND PROMISE FOR PRENATAL DRUG and Kathleen K. Sulik CO-EXPOSURE RESEARCH

MODULATORY INFLUENCE OF THE DEVELOPING ENDOCANNABINOID Anja Goepfrich SYSTEM ON COGNITIVE ABILITIES P1-37 and Miriam Schneider DURING ADOLESCENT BRAIN DEVELOPMENT IN RATS

TOPIC D. Cannabinoids and Cancer

LYPLA2 IS A MAJOR PROSTAGLANDIN Joseph D. Manna GLYCEROL ESTER HYDROLASE IN P1-38 and Lawrence J. Marnett HUMAN CANCER CELLS

Elisa Bisicchia, Filomena Fezza, Emanuela Talamonti, Mirko Lanuti, ROLE OF THE ENDOCANNABINOID P1-39 Valerio Chiurchiù, Sergio Oddi, SYSTEM IN AUTOPHAGY Marco Molinari and Mauro Maccarrone

Tiziana Bisogno, Alberto Rainer, Luca Businaro, ANALYSIS OF ENDOCANNABINOID Emanuela Talamonti, Marcella SYSTEM IN A 3D “CELL-ON-CHIP” P1-40 Trombetta, Daniele Santini MODEL OF HUMAN TUMORS and Mauro Maccarrone

CYCLOOXYGENASE-2-DEPENDENT Seok-Woo Park GROWTH INHIBITION OF P1-41 and Myung-Whun Sung ARACHIDONOYL ETHANOLAMIDE ON LARYNGEAL CANCER CELLS

DEVELOPMENT OF A Δ9-THC PRODRUG TRANSDERMAL DELIVERY SYSTEM FOR Stan L. Banks, Miro Golinski, PREVENTION OF ACUTE AND DELAYED Jeff Howard, Dana Hammell NAUSEA AND VOMITING ASSOCIATED P1-42 and Audra L. Stinchcomb WITH INITIAL AND REPEAT COURSES OF EMETOGENIC CANCER CHEMOTHERAPY

Maria Chiara Proto, Antonio Christian Pagano Zottola, Donatella Fiore, Simona ENDOCANNABINOID-INDUCED Pisanti, Paola Picardi, Elena GROWTH INHIBITION OF HUMAN P1-43 Ciaglia, Anna Maria Malfitano, COLON CANCER: INVOLVEMENT OF Alba D’Alessandro, Chiara WNT/β-CATENIN PATHWAY Laezza, Maurizio Bifulco and Patrizia Gazzerro

A REVIEW OF THE USE OF HERBAL N. Rielle Capler CANNABIS AND CANNABIS EXTRACTS P1-44 and Lynda G. Balneaves FOR THE TREATMENT OF CANCER AND CANCER-RELATED SYMPTOMS

AN IN VITRO EVALUATION Thomas D. M. Hill, OF COMBINATIONS OF Colin G. Stott PHYTOCANNABINOIDS IN PANCREATIC, P1-45 and Marnie Duncan GASTRIC, RENAL, BLADDER AND LIVER CANCER CELL LINES

EFFECT OF N-ARACHIDONOYH Ghayth M. Abdulrazzaq, GLYCIN (NAGly) AND Sue Chan ∆9 -TETRAHYDROCANNABINOL P1-46 and Stephen PH Alexander (∆9THC) ON ERK1/2 PHOSPHORYLATION IN NATIVE HEK293 CELLS

TOPIC E. Cannabinoid Receptors and Signaling

Elham Khajehali, ALLOSTERIC MODULATION AND Daniel T. Malone BIASED SIGNALLING AT CB1 P1-47 and Katie Leach CANNABINOID RECEPTORS

Orla Haugh, PROFILING THE ACTIVITY Cullen McCulloch, OF GPR55 ANTAGONISTS P1-48 June Penman AGAINST RECOMBINANT and Andrew J. Irving AND ENDOGENOUS GPR55

ROLE OF INTRACELLULAR LOOPS IN Jagjeet Mnpotra, Diane Lynch, THE HYDRATION OF GDP: RESULTS Alan Grossfield, Nicholas FROM MOLECULAR DYNAMICS P1-49 Leioatts, Michael Pitman SIMULATIONS OF THE 2-AG and Patricia Reggio ACTIVATED CANNABINOID RECEPTOR SUBTYPE 2 / Gi PROTEIN COMPLEX

CB1 RECEPTOR INTRACELLULAR LOOP Khalil Eldeeb, Sandra Leone- 4 MUTATION MODULATES G PROTEIN Kabler, Lawrence C. Blume P1-50 ACTIVATION AND CAMP PRODUCTION and Allyn C. Howlett IN HUMAN NEUROBLASTOMA CELLS

POSTER SESSION 2: TOPICS E - H DAY 3, TUESDAY, July 1st: 13:15 - 15:00

TOPIC E (cont.) Cannabinoid Receptors and Signaling

Matthew W. Buczynski, Melissa A. Herman, Ku-Lung CHRONIC NICOTINE EXPOSURE Hsu, Luis A. Natividad, DIMINISHES INHIBITORY CONTROL Cristina Irimia, Ilham Y. Polis, OF VTA DA NEURONS THROUGH Holly Pugh, Jae Won Chang, ENHANCED DIACYLGLYCEROL P2-1 Micah J. Niphakis, LIPASE-MEDIATED Benjamin F. Cravatt, 2-ARACHIDONOYLGLYCEROL Marisa Roberto SIGNALING and Loren H. Parsons

A GPR119-BASED SIGNALING SYSTEM Alex Straiker, Sherry Hu, IN THE MURINE EYE REGULATES Karl Spork, Emma Leishmann P2-2 INTRAOCULAR PRESSURE IN A and Heather Bradshaw SEX-DEPENDENT MANNER

CANNABINOID CB1 RECEPTOR- Richard S Priestley, MEDIATED ERK1/2 RESPONSES - Sarah A. Nickolls, EVIDENCE OF G PROTEIN- P2-3 Stephen P.H. Alexander I/O INDEPENDENT SIGNALLING and David A Kendall AND AGONIST BIAS

Toru Uyama, Manami Inoue, Yoko Okamoto, Naoki PEROXISOMAL DYSFUNCTION BY Shinohara, Tatsuya Tai1, PLA/AT FAMILY PROTEINS IS NOT Masahiro Watanabe, Iffat Ara P2-4 RELATED TO THEIR NAPE-FORMING Sonia Rahman, Kazuhito N-ACYLTRANSFERASE ACTIVITY Tsuboi, Tomohito Inoue, Akira Tokumura and Natsuo Ueda

Jayendra Z. Patel, Stephen Ahenkorah, Yahaya Adams, Susanna M. Saario, Teija LORATADINE ANALOGUES P2-5 Parkkari, Juha R. Savinainen, AS MAGL INHIBITORS Jarmo T. Laitinen and Tapio Nevalainen

Dow P. Hurst, Diane L. Lynch, MODELING THE ORG27569 INDUCED Derek M. Shore, CB1/BETA-ARRESTIN 1 COMPLEX THAT P2-6 Michael C. Pitman ACTIVATES AN ARRESTIN BIASED and Patricia H. Reggio PATHWAY

PHARMACOLOGICAL William A. Devane CHARACTERISATION OF A BINDING P2-7 and David P. Finn SITE FOR [3H]LEELAMINE

Abhijit R. Kulkarni, Pushkar M. Kulkarni, Anisha Korde, DESIGN, SYNTHESIS AND Nicolai Zvonok, BIOCHEMICAL EVALUATION OF NOVEL Maria Grazia Cascio, ELECTROPHILIC AND PHOTOAFFINITY P2-8 Alexandros Makriyannis, COVALENT PROBES TO MAP THE CB1 Roger G. Pertwee RECEPTOR ALLOSTERIC SITE(S) and Ganesh A. Thakur

REVIEW OF EVIDENCE FOR Saoirse O’Sullivan, CANNABINOID RECEPTORS AND Sara Goodacre ENDOCANNABINOID SIGNALLING IN P2-9 and Jonathan Yee INVERTEBRATES WITH A SPECIFIC FOCUS ON ARACHNIDS

Carmen Rodríguez-Cueto, ANALYSIS OF THE ENDOCANNABINOID Mariluz Hernández-Gálvez, SIGNALING SYSTEM IN BRAIN Cecilia J. Hillard, Patricia P2-10 STRUCTURES OF SCA-3 Maciel, Javier Fernández-Ruiz TRANSGENIC MICE and María Gómez-Ruiz

THE N-ACYL AMINO ACIDS, June Penman, N-ARACHIDONOYL-L-SERINE Emanuel Ferreira Lopes P2-11 AND N-ARACHIDONOYL GLYCINE, and Andrew J. Irving ACTIVATE GPR55

SIMULTANEOUS DETERMINATION OF ENDOCANNABINOID AND Christoph Porazik, PROSTAGLANDIN BIOMARKERS AND Anke Witting P2-12 OF MONOACYLGLYCEROL LIPASE and Boris Ferger INHIBITOR EXPOSURE USING A NEW AND FAST LC-MS/MS-METHOD

EFFECTS OF NOVEL SEMI-SYNTHETIC Marcus R. Goetz, Oskar Koch, CANNABINOIDS ON CB1 AND CB2 Eduardo Munoz E P2-13 RECEPTORS THROUGH BINDING AND and Bernd L. Fiebich SIGNALLING

REVIEW OF THE EVIDENCE FOR Jonathan Yee, CANNABINOID RECEPTORS IN Saoirse O’Sullivan P2-14 INVERTEBRATES WITH A SPECIFIC and Sara Goodacre FOCUS ON ARACHNIDS

TOPIC F. Cannabis Use and Abuse Issues

CANNABIS OIL – CHEMICAL Luigi L. Romano EVALUATION OF AN UPCOMING P2-15 and Arno Hazekamp CANNABIS-BASED MEDICINE

Jennifer Johnston, Nicholas Lintzeris, David J. LITHIUM CARBONATE IN THE Allsop, Anastasia Suraev, MANAGEMENT OF CANNABIS Jessica Booth, Dean S. Carson, WITHDRAWAL: A RANDOMIZED P2-16 David Helliwell, PLACEBO-CONTROLLED TRIAL Adam Winstock IN AN INPATIENT SETTING and Iain S. McGregor

CANNABIS USE AND PERPETRATION Kim Crosby OF INTIMATE PARTNER VIOLENCE: P2-17 and Zach Walsh THE MODERATING ROLE OF PROBLEMATIC ALCOHOL USE

Brian F. Thomas, WHAT GOES UP IN SMOKE: Richard C. Daw, Poonam G. THE IDENTIFICATION AND Pande, Anderson O. Cox, PHARMACOLOGICAL Alex L. Kovach, Kenneth H. CHARACTERIZATION OF P2-18 Davis, Jenny L. Wiley, SYNTHETIC CANNABINOID Kenneth S. Rehder PYROLYSIS PRODUCTS FORMED and Megan Grabenauer DURING SMOKING

Sonia Aroni, Claudia Sagheddu, NEURONAL CIRCUITS UNDERLYING Marco Pistis P2-19 CANNABINOID WITHDRAWAL and Anna Lisa Muntoni

Kiri L.Wills, Kiran Vemuri, DELIVERY OF THE CB1 ANTAGONIST, Alana Kalmar, AM251, BILATERALLY TO THE CENTRAL Cheryl L. Limebeer, P2-20 NUCLEUS OF THE AMYGDALA AND ITS Alexandros Makriyannis EFFECTS ON MORPHINE WITHDRAWAL and Linda A. Parker

BDNF INTERACTS WITH Yong Liu, Ying Hu, ENDOCANNABINOIDS TO REGULATE Peng Zhong COCAINE-INDUCED SYNAPTIC P2-21 and Qing-song Liu PLASTICITY IN MOUSE MIDBRAIN DOPAMINE NEURONS

INTEGRAL FRAMES: Regina Nelson INTERDISCIPLINARY TOOLS P2-22 SUPPORTING CANNABIS RESEARCH

C57BL6/J DEVELOP TOLERANCE TO Travis Grim, CP55,940 IN INTRACRANIAL SELF- Jason Weibelhaus, Steve Negus P2-23 STIMULATION OF THE MEDIAL and Aron Lichtman FOREBRAIN BUNDLE

CANNABINOID CB1 RECEPTOR TRANSMISSION IN THE BASOLATERAL AMYGDALA BI-DIRECTIONALLY Tasha Ahmad CONTROLS THE MOTIVATIONAL P2-24 and Steven R. Laviolette PROPERTIES OF OPIATES VIA FUNCTIONAL EXCITATORY INPUTS TO THE NUCLEUS ACCUMBENS SHELL

Kristin M. Gabella, -PRECIPITATED ∆9-THC Margaret S. Jones, WITHDRAWAL ALTERS MARBLE Molly S. Crowe, P2-25 BURYING AND STRUGGLING Sara R. Nass BEHAVIORS IN MICE and Steven G. Kinsey

FATTY ACID AMIDE HYDROLASE Lena Bergström, Shima (FAAH) ACTIVITY IN DIFFERENT RAT Momeni, Hanna Eriksson- P2-26 BRAIN REGIONS AFTER TWO WEEKS Röhnisch and Erika Roman TREATMENT WITH ETHANOL

TOPIC G. Metabolism

Tania Muller, Stephanie Troy- ACTIVATION OF ADIPOSE TISSUE Fioramonti, Laurent Demizieux, CANNABINOID RECEPTORS 1 Joseph Gresti, Maria Bouam, (CB1R) ALTERS ANTILIPOLYTIC P2-27 BrunoVergès ACTION OF INSULIN AND and Pascal Degrace INCREASES LIPOLYSIS IN MICE

PERIPHERAL ENDOCANNABINOID Stephanie Troy-Fioramonti, SYSTEM ACTIVATION INHIBITS Laurent Demizieux, INTESTINAL GLUCOSE ABSORPTION P2-28 Joseph Gresti, Bruno Vergès AND IMPROVES POSTPRANDIAL and Pascal Degrace GLYCEMIA IN LEAN AND OBESE MICE

Maria Scherma, PHARMACOLOGICAL MODULATION Valentina Satta, Roberto Collu, OF THE ENDOCANNABINOID P2-29 Liana Fattore, Paola Fadda SYSTEM IN A RODENT MODEL and Walter Fratta OF “ACTIVITY-BASED ANOREXIA”

SYNTHESIS AND CHARACTERIZATION Oliver Linsell, Khaled Greish OF A NANOMICELLE CANNABINOID P2-30 and John C. Ashton FORMULATION

INHIBITION OF ENDOCANNABINOID Jessica Karlsson METABOLISM BY THE METABOLITES P2-31 and Christopher J. Fowler OF IBUPROFEN AND FLURBIPROFEN

Sandra Gouveia-Figueira, DIETARY EFFECTS ON CIRCULATING Jana Späth, Angela Zivkovic P2-32 OXYLIPINS AND ENDOCANNABINOIDS and Malin L. Nording

Giovanna Morello, Roberta OREXIN-A ENHANCES 2-AG Imperatore, Fabiana Piscitelli, BIOSYNTHESIS VIA CB1/OX-1R Daniela Sarnataro, Letizia HETEROMERS IN THE NEURONS P2-33 Palomba, Luciano De OF THE MOUSE HYPOTHALAMIC Petrocellis, Luigia Cristino ARCUATE NUCLEUS and Vincenzo Di Marzo

Julius T. Dongdem, INHIBITION OF RAT LIVER FAAH Simon P. Dawson ACTIVITY USING THREE DIFFERENT P2-34 and Stephen P. H. Alexander FATTY ACID AMIDES AS SUBSTRATES

Antoni Pastor, Magí Farré, EX-VIVO ENZYMATIC GENERATION Montserrat Fitó, OF 2-AG AND OTHER P2-35 Fernando Fernandez-Aranda 2-MONOACYLGLYCEROLS IN PLASMA and Rafael de la Torre

Caroline Turcotte, Cyril Martin, EXPRESSION OF ENZYMES INVOLVED Véronique Provost IN ENDOCANNABINOID METABOLISM P2-36 and Nicolas Flamand BY HUMAN LEUKOCYTES

TOPIC H. CNS and Psychiatric Issues

Tamar Harpaz, Merav Hajbi, Efrat Sasson, SR141716A-INDUCED HYPERACTIVITY Tamar Blumenfeld-Katzir, P2-37 IS NOT REVERSED BY RITALIN Iain Greig, Ester Fride (Z”L) and Sharon Anavi-Goffer

Krisztina Monory, CANNABINOID CB1 RECEPTOR Martin Polack, Anita Remus, CALIBRATES EXCITATORY P2-38 Beat Lutz SYNAPTIC BALANCE IN and Martin Korte THE MOUSE HIPPOCAMPUS

THE THERAPEUTIC EFFICACY Robert B. Laprairie, OF CANNABINOID RECEPTOR TYPE 1 Amina M. Bagher, Melanie (CB1) LIGANDS IN HUNTINGTON’S P2-39 E.M. Kelly, Denis J. Dupré DISEASE DEPENDS ON THEIR and Eileen M. Denovan-Wright FUNCTIONAL SELECTIVITY

EVALUATION OF PHYTOCANNABINOID Sara Valdeolivas, COMBINATIONS AS A DISEASE- Onintza Sagredo MODIFYING THERAPY IN R6/2 MICE, P2-40 and Javier Fernández-Ruiz A GENETIC MODEL OF HUNTINGTON’S DISEASE

Fabricio A. Moreira, Luciano R. Vilela, Pedro H. INHIBITION OF FATTY ACID AMIDE Gobira, Daniel C. Medeiros, HYDROLASE (FAAH) PREVENTS P2-41 Fabiola M. Ribeiro, COCAINE-INDUCED SEIZURE AND Antonio C. de Oliveira NEUROTOXICITY and Marcio F. Moraes

Sabrina F. Lisboa, Andréia L. REPEATED TREATMENT WITH THE da Silva, Laura H.A. Camargo, FAAH INHIBITOR URB597 ATTENUATES P2-42 Leonardo B.M. Resstel LONG-LASTING CONSEQUENCES OF and Francisco S. Guimarães PREDATOR EXPOSURE IN MICE

Christine A. Rabinak, Shoko CANNABINOID EFFECTS ON Mori, Maryssa Lyons, Mike PREFRONTAL ACTIVATION DURING P2-43 Angstadt and K. Luan Phan REGULATION OF NEGATIVE AFFECT

DISSOCIATING THE PSYCHOACTIVE Jordan Zunder, EFFECTS OF DISTINCT MARIJUANA Michael Loureiro P2-44 COMPOUNDS IN THE and Steven R. Laviolette MESOCORTICOLIMBIC CIRCUITRY

Antonia Manduca, Maria DUAL FATTY ACID AMIDE HYDROLASE Morena, Michela Servadio, AND MONOACYLGLYCEROL LIPASE Lidia Montebello, Riccardo P2-45 INHIBITION AFFECTS SOCIO- Dore, Patrizia Campolongo EMOTIONAL RESPONSES IN RATS and Viviana Trezza

Noemi Pasquarelli, Michael THERAPEUTIC EFFECT OF THE Engelskirchen, Johannes MONOACYLGLYCEROL LIPASE Hanselmann, Christoph INHIBITOR KML29 IN THE SOD1G93A P2-46 Porazik, Diana Wiesner, MOUSE MODEL OF AMYOTROPHIC Patrick Weydt, Meliha Karsak, LATERAL SCLEROSIS Boris Ferger and Anke Witting

CANNABIDIOL AND ULTRA-LOW DOSES OF TETRAHYDROCANNABINOL Miriam Fishbein-Kaminietsky, PROVIDE TWO DIFFERENT Mikhal Gafni P2-47 MODES OF NEUROPROTECTION and Yosef Sarne AGAINST INFLAMMATION- INDUCED COGNITIVE DAMAGE

Natalia I. Brzozowska, REPEATED LOW-DOSE Δ9-THC Aurelie A. Boucher, PROMOTES LONG-TERM REDUCTIONS Kong M. Li, Alex Wong, IN THE ACTUE NEUROBEHAVIOURAL P2-48 Xiao Suo Wang EFFECTS OF THE ATYPICAL and Jonathon C. Arnold ANTIPSYCHOTIC RISPERIDONE

Floor Remmers , Martina GLUTAMATERGIC AND Hamann, Hector Romo-Parra, GABAERGIC COMPONENTS OF THE Sabine Ruehle, ENDOCANNABINOID SYSTEM AND P2-49 Giovanni Marsicano, THEIR INVOLVEMENT IN PROCESSING Hans-Christian Pape OF INNATE AND LEARNED FEAR and Beat Lutz

ENDOCANNABINOID AUGMENTATION Joyonna C. Gamble-George, THROUGH SUBSTRATE-SELECTIVE Daniel J. Hermanson, COX-2 INHIBITION: BEHAVIORAL P2-50 Lawrence J. Marnett EFFECTS IN AN ANIMAL MODEL OF and Sachin Patel STRESS-INDUCED ANXIETY

POSTER SESSION 3: TOPICS H - K DAY 4, Wednesday, July 2nd: 13:00 - 15:00

TOPIC H (cont.) CNS and Psychiatric Issues

CHRONIC ADOLESCENT CANNABINOID Silvain S. Dang, EXPOSURE CAUSES LONG-TERM Tiffany T.Y. Lee P3-1 CHANGES IN ADULT SEXUAL and Boris B. Gorzalka BEHAVIOUR IN MALE RATS

ELEVATION OF KYNURENIC ACID Claudia Sagheddu, LEVELS SUPPRESSES DELTA9- Salvatore Lecca, TETRAHYDROCANNABINOL-INDUCED Antonio Luchicchi, EXCITATION OF MESOLIMBIC P3-2 Steven Goldberg DOPAMINE AND PREFRONTAL CORTEX and Marco Pistis PYRAMIDAL NEURONS

PROTEIN KINASE-C GAMMA Maria Gomis-González, INVOLVEMENT IN THE NEGATIVE Arnau Busquets-Garcia, EFFECTS PRODUCED BY DELTA9- P3-3 Emma Puighermanal, Rafael TETRAHYDROCANNABINOL ON Maldonado and Andrés Ozaita MEMORY CONSOLIDATION

AN INVESTIGATION OF PANX 1 Steven G. Fagan MEMBRANE CHANNELS IN and Veronica A. Campbell P3-4 CANNABINOID MEDIATED

NEUROPROTECTION

Filomena Fezza, Maria Cristina DISTINCT MODULATION OF Marrone, Riccardo Avvisati, THE ENDOCANNABINOID SYSTEM Monia Di Tommaso, Mirko UPON KAINIC ACID-INDUCED P3-5 Lanuti, Cinzia Rapino, Nicola IN VIVO SEIZURES AND IN VITRO B. Mercuri, Silvia Marinelli EPILEPTIFORM BURSTING and Mauro Maccarrone

LONG-TERM EFFECTS OF ADOLESCENT Tiffany T.-Y. Lee, CB1 RECEPTOR ANTAGONISM: Matthew N. Hill RELEVANCE TO STRESS RESPONSIVITY P3-6 and Boris B. Gorzalka AND EMOTIONAL BEHAVIOUR IN ADULT MALE RATS

Vincenzo Micale, Vladimír EARLY MODIFICATION OF THE Pekařík, Fabio Iannotti, ENDOCANNABINOID SYSTEM Jana Kucerova, Teresa Aveta, ACCOMPANIES THE LATE Katarina Tabiová, P3-7 BEHAVIORAL PHENOTYPE Filippo Drago, OF A RODENT DEVELOPMENTAL Vincenzo Di Marzo MODEL OF SCHIZOPHRENIA and Alexandra Sulcova

Anastasia Piyanova, Onder Albayram, Carlo LOSS OF CB1 RECEPTORS LEADS Alberto Rossi, Hany Farwanah, TO DECREASED CATHEPSIN D LEVELS Kerstin Michel, P3-8 AND ACCELERATED LIPOFUSCIN Pierluigi Nicotera, ACCUMULATION IN THE HIPPOCAMPUS Konrad Sandhoff and Andras Bilkei-Gorzo

Mikael Alexander Kowal, Arno Hazekamp, Lorenza Serena Colzato, THE EFFECT OF CANNABIS ON Jeffrey Durieux, Meriem DIVERGENT AND CONVERGENT P3-9 Manai, Nic van der Wee, THINKING: THE ROLE OF DOPAMINE Henk van Steenbergen and Bernhard Hommel

Rebecca Henry, FAAH-MEDIATED MODULATION OF Daniel Kerr, TLR3-INDUCED NEUROINFLAMMATION P3-10 David P. Finn IN THE RAT HIPPOCAMPUS and Michelle Roche

TIME COURSE CHANGES OF CB1 AND Ana Belen Lopez-Rodriguez, CB2 RECEPTORS AFTER TRAUMATIC Estefania Acaz-Fonseca, BRAIN INJURY IN MALE AND FEMALE P3-11 Luis M. Garcia-Segura MICE: STRUCTURAL AND FUNCTIONAL and Maria-Paz Viveros CORRELATES

TOPIC I. Cannabinoid Genetics

Kateřina Tejkalová THE SATIVA-INDICA DILEMMA P3-12 and Arno Hazekamp

Andrea Di Francesco, Anastasia Falconi, Clara Di Germanio, Carlo Cifani, Maria Vittoria EFFECTS OF EXTRA VIRGIN Micioni Di Bonaventura, OIL PHENOLIC COMPOUNDS ON Monica Bari, Stefano Caramuta, P3-13 CB1 GENE EXPRESSION: A ROLE Michele Del Carlo, Dario FOR EPIGENETIC MECHANISMS Compagnone, Enrico Dainese, Claudio D'Addario and Mauro Maccarrone

DEVELOPMENT OF A FLOW CYTOMETRY-BASED BRET ASSAY Morag Rose Hunter, UTILISING GENETICALLY-ENCODED Stephen G Edgar P3-14 BIOSENSORS FOR MIXED CELL and Michelle Glass POPULATIONS: APPLICATION TO CANNABINOID CB1 RECEPTORS

Pamela Prini, ADOLESCENT THC EXPOSURE INDUCES Zamberletti Erica, Gabaglio EPIGENETIC CHANGES AND ALTERS P3-15 Marina, Parolaro Daniela GENE EXPRESSION IN THE RAT and Rubino Tiziana PREFRONTAL CORTEX

TOPIC J. Focus on CB2

Zebing Huang, Ming Gao, SELECTIVE ACTIVATION OF CB2RS Zhengxiong Xi, ELIMINATES AGONIST-INDUCED CA2+ Qingrong Liu, SIGNALS IN PANCREATIC ACINAR P3-16 Xuegong Fan CELLS: A NOVEL CELLULAR and Jie Wu MECHANISM FOR ACUTE PANCREATITIS THERAPEUTICS

Bernhard Reis, Jeremy Beauchamp, Jürgen Fingerle, Uwe Grether, Hugues Matile, A NEW ANTI MOUSE CB2 Matthias Nettekoven, Mark ANTIBODY SENSITIVE TO P3-17 Rogers-Evans, Stephan Röver, RECEPTOR CONFORMATION Sannah Jensen-Zoffmann and Christoph Ullmer

Valeria Gasperi, Daniela Evangelista, Valerio Chiurchiù, 2-ARACHIDONOYLGLYCEROL Fulvio Florenzano, Isabella PROMOTES LEUKOCYTE RECRUITMENT P3-18 Savini, Sergio Oddi, Luciana THROUGH CB1 AND CB2 RECEPTORS Avigliano, M. Valeria Catani and Mauro Maccarrone

Joel Sardinha, CANNABINOID 2 Melanie Kelly, Juan Zhou RECEPTOR MODULATION P3-19 and Christian Lehmann IN EXPERIMENTAL SEPSIS

James Toguri, C. Lehmann, R. Laprairie, A. Bagher, CB2R MODULATION OF LPS-INDUCED A.M. Szczesniak, TOLL-LIKE RECEPTOR 4 SIGNALLING P3-20 E. Denovan-Wright IN OCULAR INFLAMMATION and M.E.M. Kelly

CANNABINOID RECEPTOR 2: A NOVEL Anna-Maria Szczesniak, IMMUNOSUPPRESIVE TARGET IN Heather B. Bradshaw P3-21 EXPERIMENTAL PROLIFERATIVE and Melanie E.M. Kelly VITREORETINOPATHY

Christa van Kralingen, ASSESSMENT OF CB2 IN HUMAN BRAIN David Findlay, Michelle Glass P3-22 TISSUE USING IN SITU HYBRIDISATION and E Scott Graham

DIFFERENTIAL EXPRESSION AND Kristina Burkert, Dan Ting FUNCTION OF THE CB2 RECEPTOR IN Kho, Catherine E Angel, DISTINCT SUBSETS OF HUMAN P3-23 Michelle Glass MONOCYTES AND MACROPHAGES and E Scott Graham FROM BLOOD

Carmen Vázquez, Concepción García, Rosa María Tolón, NEW MOUSE MODEL FOR THE STUDY P3-24 Bonnie Dittel, Julián Romero OF CB2 CANNABINOID RECEPTORS and Cecilia Hillard

TOPIC K. Beyond THC: Cannabidiol and Other Components

NON-PSYCHOACTIVE PHYTOCANNABINOIDS FOR THE Daniel I. Brierley, TREATMENT OF CANCER ANOREXIA- Benjamin J. Whalley P3-25 CACHEXIA SYNDROME: EVIDENCE FOR and Claire M. Williams THE THERAPEUTIC POTENTIAL OF

Tiziana Bisogno, Alberto Rainer, RELEASE OF N-ACYLETHANOLAMINES Pamela Mozetic, Vincenzo BY BIOMATERIALS OF CLINICAL P3-26 Di Marzo, Marcella Trombetta RELEVANCE and Mauro Maccarrone

CANNABIDIOL ATTENUATES SCHIZOPHRENIA-LIKE EFFECTS Felipe V. Gomes, Elaine Del- AND CHANGES ON PARVALBUMIN Bel, Maria-Paz Viveros EXPRESSION IN THE MEDIAL P3-27 and Francisco S. Guimarães PREFRONTAL CORTEX INDUCED BY ANTAGONISM OF NMDA RECEPTORS IN MICE

CHARACTERIZATION OF STRUCTURAL Kazuhito Watanabe, Satoshi REQUIREMENTS FOR POTENT Yamaori, Yoshimi Okushima P3-28 MECHANISM-BASED INHIBITION OF and Ikuo Yamamoto HUMAN CYP1A1 BY CANNABIDIOL

Amanda Wheal, IN VIVO CANNABIDIOL TREATMENT ENHANCES VASORELAXATION TO Michael Randall ACETYLCHOLINE AND SODIUM P3-29 and Saoirse O'Sullivan NITROPRUSSIDE IN ARTERIES FROM ZUCKER DIABETIC RATS

Nagat El Demerdash, M Ruth TEMPORARY THERAPEUTIC WINDOW Pazos, Maria Ceprian, Laura OF CANNABIDIOL FOR P3-30 Jimenez, Ola Didrik Saugestad NEUROPROTECTION AFTER BRAIN and Jose Martinez- Orgado HYPOXIA-ISCHEMIA IN NEWBORN MICE

THE EFFECT OF CBD, CBG, Prathibha M Daniel, AND THCV ON UWB1.289, A HUMAN Roger M. Phillips NON-HORMONE DEPENDANT P3-31 and Farideh A Javid OVARIAN CARCINOMA CELL LINE

Neta Rimmerman, Sarah Atkins, Sheila Langier, CANNABIDIOL REDUCES Emma Leishman, Heather B. INFLAMMATORY AIRWAY IMMUNE P3-32 Bradshaw, Ewa Kozela, CELL ACCUMULATION IN A MOUSE Ana Juknat, Shmuel Kivity MODEL OF ALLERGIC ASTHMA and Zvi Vogel

CANNABIDIOL ACTIVATES GLYCOGEN XiaoQian Liu, Leyu Shi SYNTHASE KINASE IN NEURONS: P3-33 and Cecilia J. Hillard EVIDENCE FOR MEDIATION BY CHANGES IN CELLULAR REACTIVE OXYGEN SPECIES

William Hind, PHARMACOLOGICAL PROPERTIES OF Maria Grazia Cascio, PURE AND P3-34 Roger Pertwee CANNABICHROMENE BOTANICAL and Marnie Duncan DRUG SUBSTANCE

Leo Ayerakwa, Colin Stott, Marnie Duncan, EVALUATION OF THE GENOTOXICITY P3-35 Stephen Wright OF CANNABIDIOLIC ACID and Geoffrey Guy

Marnie Duncan, PHARMACOLOGICAL PROPERTIES Maria G Cascio, OF PURE CANNABIGEROL AND Roger Pertwee, P3-36 CANNABIGEROL BOTANICAL DRUG Gernot Reidel, Naoki Amada SUBSTANCE and Yuki Yamasaki

THE PHYTOCANNABINOID, Maria Grazia Cascio, Δ9-TETRAHYDROCANNABIVARIN, Erica Zamberletti, CAN ACT THROUGH 5-HT1A P3-37 Pietro Marini, Daniela Parolaro RECEPTORS TO PRODUCE and Roger G. Pertwee ANTI-PSYCHOTIC EFFECTS

Nicholas Jones, Isabelle Pérès, THE PHYTOCANNABINOID Rebecca Hadid, Naoki Amada, DEMONSTRATES Charlotte Hill, NOTABLE ANTIEPILEPTIC P3-38 Ahlam Alhusaini, Andy Hill, PROPERTIES AND IS A GENUINE Claire Williams CANDIDATE FOR THE TREATMENT and Ben Whalley OF TEMPORAL LOBE EPILEPSY

PHARMACOLOGICAL PROPERTIES, PHARMACOKINETICS AND Nicholas Jones, BIOAVAILABILITY OF PURE Leo Ayerakwa, Colin Stott P3-39 CANNABIDIOLIC ACID AND and Marnie Duncan CANNABIDIOLIC ACID BOTANICAL DRUG SUBSTANCE

THE NON-PSYCHOTROPIC PLANT Fabio A. Iannotti, CANNABINOIDS, CANNABIDIVARIN Charlotte L. Hill, Antonio Leo, (CBDV) AND CANNABIDIOL (CBD), Camille Soubrane, ACTIVATE AND DESENSITIZE Enrico Mazzarella, TRANSIENT RECEPTOR POTENTIAL P3-40 Emilio Russo, VANILLOID 1 (TRPV1) CHANNELS IN Benjamin J. Whalley, VITRO: POTENTIAL FOR THE Vincenzo Di Marzo TREATMENT OF NEURONAL and Gary J. Stephens HYPEREXCITABILITY

INFLUENCE OF HEPATIC METABOLISM Cristoforo Silvestri, OF Δ9-TETRAHYDROCANNABIVARIN Andrea Martella, (THCV) AND CANNABIDIOL (CBD) P3-41 Marnie Duncan ON THEIR ANTI-STEATOTIC and Vincenzo Di Marzo ACTIONS IN VITRO

M.R. Pazos, H. Lafuente, N. Mohamed, M. Ceprian, ADDITIVE NEUROPROTECTIVE EFFECT M. Santos, L. Arruza, OF CANNABIDIOL AND HYPOTHERMIA P3-42 F.J. Alvarez Diaz IN HYPOXIC-ISCHEMIC PIGLETS and J. Martínez-Orgado

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