US 2013 0171145A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0171145 A1 Devi et al. (43) Pub. Date: Jul. 4, 2013

(54) METHODS OF TREATING LIVER DISEASE Publication Classification (75) Inventors: Lakshi A. Devi, New Rochelle, NY (51) Ek'.I/7076 (2006.01) y Raphael Rozenfeld, Swampscott, C07K 6/28 (2006.01) A613 L/454 (2006.01) (52) U.S. Cl. (73) Assignee: MOUNTSINAISCHOOL OF CPC ...... A6 IK3I/7076 (2013.01); A61 K3I/454 MEDICINE, New York, NY (US) (2013.01); C07K 16/2869 (2013.01); C07K I6/286 (2013.01) (21) Appl. No.: 13/575,220 USPC ...... 424/136.1: 514/326; 514/45; 530/387.3: 435/7.1 (22) PCT Filed: Jan. 25, 2011 (57) ABSTRACT (86). PCT No.: PCT/US2O11?0224.52 Compounds and compositions useful for the treatment of S371 (c)(1), liver diseases and methods of treating liver diseases are dis (2), (4) Date: Mar. 18, 2013 closed. The compounds of the invention specifically interact with heteromers of receptors as compared to O O monomers or homodimers. The invention also relates to Related U.S. Application Data methods of screening for compounds useful for the treatment (60) Provisional application No. 61/297.895, filed on Jan. of liver diseases and to methods of screening for diacylglyc 25, 2010. erol lipase inhibitors. Patent Application Publication Jul. 4, 2013 Sheet 1 of 21 US 2013/0171145 A1

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