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ND 22 ANNUAL SYMPOSIUM OF THE INTERNATIONAL CANNABINOID RESEARCH SOCIETY KONZERTHAUS FREIBURG FREIBURG IM BREISGAU GERMANY JULY 22 - 27, 2012 ND 22 ANNUAL SYMPOSIUM OF THE INTERNATIONAL CANNABINOID RESEARCH SOCIETY FREIBURG JULY 22 - 27, 2012 PROGRAMME AND ABSTRACTS Symposium Programming by Cortical Systematics LLC Copyright © 2012 International Cannabinoid Research Society Research Triangle Park, NC USA ISBN: 978-0-9658053-5-3 These abstracts may be cited in the scientific literature as follows: Author(s), Abstract Title (2012) 22nd Annual Symposium on the Cannabinoids, International Cannabinoid Research Society, Research Triangle Park, NC, USA, Page #. Funding for this conference was made possible in part by grant 2R13DA016280 from the National Institute on Drug Abuse. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. ICRS Sponsors Government Sponsors National Institute on Drug Abuse Non-Profit Organization Sponsors Kang Tsou Memorial Fund 2012 Symposium on the Cannabinoids Conference Coordinators Cecilia Hillard, Ph.D. Aron Lichtman, Ph.D. Jason Schechter, Ph.D. Bela Szabo, M.D., Ph.D. Programme Committee Mary Abood, Ph.D. Steve Alexander, Ph.D. Itai Bab, D.M.D. Vincenzo Di Marzo, Ph.D. Javier Fernandez- Ruiz, Ph.D. Matthew Hill, Ph.D. Cecilia Hillard, Ph.D. Allyn Howlett, Ph.D. Aron Lichtman, Ph.D. Mauro Maccarrone, Ph.D. Ken Mackie, M.D. Roger Pertwee, D.Phil, D.Sc. Ruth Ross, Ph.D. Ethan Russo, M.D. Bela Szabo, M.D., Ph.D. Brian Thomas, Ph.D. Jenny Wiley, Ph.D. Student Travel Award Committee Allyn Howlett, Ph.D. Aron Lichtman, Ph.D. Mauro Maccarrone, Ph.D., Chair Ruth Ross, Ph.D. Jenny Wiley, Ph.D. Student Award Committee Chairs Steven Kinsey, Ph.D., Pre- Doc Chair Julián Romero, Ph.D., Post- Doc Chair Mechoulam Award Committee Francis Barth, Ph.D. Vincenzo Di Marzo, Ph.D. Cecilia Hillard, Ph.D. Allyn Howlett, Ph.D. John Huffman, Ph.D., Chair George Kunos, M.D., Ph.D. Gerard Le Fur, Ph.D. Aron Lichtman, Ph.D. Ken Mackie, M.D. Alex Makriyannis, Ph.D. Roger Pertwee, D.Phil, D.Sc. Raj Razdan, Ph.D. Patti Reggio, Ph.D. Murielle Rinaldi- Carmona, Ph.D. 2012 ICRS Board of Directors Executive Director Cecilia Hillard, Ph.D. President Aron Lichtman, Ph.D. President- Elect Jenny Wiley, Ph.D. Past President Mauro Maccarrone, Ph.D. Secretary Steve Alexander, Ph.D. Treasurer Mary Abood, Ph.D. International Secretary Roger Pertwee, D.Phil, D.Sc. Newsletter Editor Brian Thomas, Ph.D. Student Representative Antonio Luchicchi, Ph.D. Managing Director Jason Schechter, Ph.D. Registration: July 22nd, 2012 (16.00 – 19.00) Welcome Reception: 18.30 – 20.00 Day 1 Monday, July 23rd 7.30 Breakfast 8.30 Welcome and Opening Remarks Oral Session 1. Neurodegeneration CHAIRS: ANDREAS ZIMMER AND JAVIER FERNÁNDEZ-RUIZ PAGE # ENDOCANNABINOID HYDROLYSIS Daniel K. Nomura, GENERATES BRAIN PROSTAGLANDINS 8.45 Tarek A. Samad 1 THAT PROMOTE and Benjamin F. Cravatt NEUROINFLAMMATION CANNABINOID LIGANDS DIRECTLY Scott D. Smid MODIFY β-AMYLOID FIBRIL 9.00 2 and Jesper L.V. Mååg FORMATION AND ARE VARIABLY NEUROPROTECTIVE IN VITRO Anne-Caroline Schmöle, Daniele Bano, THE ROLE OF THE 9.15 Pierluigi Nicotera, ENDOCANNABINOID RECEPTOR 3 Andreas Zimmer CB2 IN NEURODEGENERATION and Judith Alferink Ryan Graves, Gareth Pryce, EFFECTS OF GENETIC DELETION AND Michaela Egertová, PHARMACOLOGICAL INHIBITION OF 9.30 Benjamin F. Cravatt, Gavin FATTY ACID AMIDE HYDROLASE IN 4 Giovannoni, Gregory J. EXPERIMENTAL AUTOIMMUNE Michael, Maurice R. Elphick ENCEPHALOMYELITIS and David Baker TARGETING CB1 RECEPTORS 9.45 Nephi Stella AND ABHD6 TO TREAT 5 R6/2 MICE SYMPTOMS Sara Valdeolivas, Onintza Sagredo, Justo PHYTOCANNABINOID-BASED García de Yébenes, Julián 10.00 MEDICINES AS DISEASE-MODIFYING 6 Romero, Roger Pertwee, AGENTS IN HUNTINGTON’S DISEASE Manuel Guzmán and Javier Fernández-Ruiz GENERATION AND Jacqueline L. Blankman, CHARACTERIZATION OF 10.15 Jonathan Z. Long ABHD12–/– MICE, A MODEL OF THE 7 and Benjamin F. Cravatt NEURODEGENERATIVE DISEASE PHARC 10.30 Coffee Break Oral Session 2. Metabolic Regulation / Cardiovascular CHAIRS: GEORGE KUNOS AND MATTHEW HILL George Kunos, Yossi Tam, Resat Cinar, PERIPHERAL CB1R INVERSE AGONISM Jeih-San Liow, 11.00 REDUCES DIET-INDUCED OBESITY BY 8 Robert Innis, REVERSING LEPTIN RESISTANCE Robert Chorvat and John F. McElroy ACTIVATION OF HYPOTHALAMIC Matthew N. Hill, Nicole FATTY ACID AMIDE HYDROLASE BY P. Bowles, Tiffany T. Lee 11.15 LEPTIN: REGULATION OF FOOD 9 Cecilia J. Hillard INTAKE AND EFFECTS OF and Bruce S. McEwen DIET-INDUCED OBESITY Susan Krzysik-Walker, THE CANNABINOID RECEPTOR Isabel Gonzalez- INVERSE AGONIST AM251 Mariscal, Morten 11.30 ALTERS MITOCHONDRIAL 10 Scheibye-Knudsen, PHYSIOLOGY VIA PROTEOLYTIC Fred Indig DEGRADATON OF ERRα and Michel Bernier CANNABIDIOL IMPROVES IMPAIRED A J Wheal, M D Randall ENDOTHELIAL FUNCTION IN 11.45 11 and S E O’Sullivan FEMORAL ARTERIES FROM ZUCKER DIABETIC RATS THE EFFECTS OF ANANDAMIDE William H Hind ON PERMEABILITY IN 12.00 12 and Saoirse E O’Sullivan A CELL CULTURE MODEL OF THE BLOOD-BRAIN BARRIER Sabina Adhikary, MODULATION OF INFLAMMATORY Hongbo Li, Mario CELL INVASION OF THE CNS 12.15 Skarica, Weimin Kong, 13 BY A CANNABINOID-2 SELECTIVE Anu Mahadevan, Doina AGONIST AFTER INJURY Ganea and Ronald Tuma 12.30-14.00 Lunch Oral Session 3. Psychiatric Diseases / Learning & Memory CHAIRS: BEAT LUTZ AND SARA JANE WARD CANNABINOIDS PREVENT THE Eti Ganon-Elazar 14.00 DEVELOPMENT OF POST-TRAUMA 14 and Irit Akirav SYMPTOMS IN A RAT MODEL OF PTSD Ozge Gunduz-Cinar, Caitlin M Schaapveld, Kathryn P. MacPherson, Resat Cinar, Joyonna Gamble- George, Karen Sugden, Benjamin Williams, Grzegorz Godlewski, Teniel ANANDAMIDE IN AMYGDALA- S Ramikie, Adam X. Gorka, MEDIATED FEAR EXTINCTION, THREAT 14.15 15 Shakiru O. Alapafuja, PROCESSING AND STRESS-REACTIVITY: Spyros P. Nikas, A TRANSLATIONAL STUDY Alexandros Makriyannis, Richie Poulton, Sachin Patel, Ahmad R. Hariri, Avshalom Caspi, Terrie E. Moffitt, George Kunos and Andrew Holmes MEDICAL CANNABIS/MARIJUANA USE IN POST-TRAUMATIC STRESS 14.30 Ilya Reznik 16 DISORDER: A LONGITUDINAL FOLLOW-UP STUDY ANXIOGENIC-LIKE EFFECT OF Moriah Iverson THC IS LOST IN MICE LACKING 14.45 17 and Cecilia J. Hillard BETA-ARRESTIN-2: EVIDENCE FOR SEX-DEPENDENT EFFECTS Daniela Hauer, Piray ENDOCANNABINOID- Atsak, Raquel V. Fornari, GLUCOCORTICOID INTERACTION IN 15.00 Patrizia Campolongo, 18 THE BASOLATERAL AMYGDALA Gustav Schelling DURING MEMORY CONSOLIDATION and Benno Roozendaal Maria Morena, Viviana Trezza, Sergio Scaccianoce, CANNABINOIDS MODULATION OF Alessandro Pasquale, OBJECT RECOGNITION MEMORY IN 15.15 Vincenzo Cuomo, 19 RATS: INVOLVEMENT OF THE Gustav Schelling, GLUCOCORTICOID SYSTEM Benno Roozendaal and Patrizia Campolongo Xiang-Qun Xie, Rentian Feng, Peng Yang, Junpei Teramachi, Qin Tong, CANNABINOID RECEPTOR CB2. 15.30 Lirong Wang, Zhaojun A NEW DRUG TARGET FOR 20 Xie, Kyaw Myint, MULTIPLE MYELOMA INTERVENTION Noriyoshi Kurihara and David G. Roodman Poster Session 1 15.45-17.45 P1 Coffee Presidential Plenary Speaker “PLANNING RESEARCH FOR THE NEXT HALF A CENTURY” 18.00 Raphael Mechoulam, Ph.D. Institute for Drug Research Hebrew University of Jerusalem Day 2 Tuesday, July 24th 7.30 Breakfast Oral Session 4. Receptor Signaling CHAIRS: HEATHER BRADSHAW AND MARY ABOOD Mark Bauer, Andrea Chicca, Stefanie IDENTIFICATION OF A FAMILY OF Hofer-Reyes, Marco PEPTIDE ENDOCANNABINOIDS 8.30 Tamborrini, David Eisen, (PEPCANS): EVIDENCE FOR 21 Oliver Poetz, ALLOSTERIC MODULATION Gerd Pluschke OF CB1 RECEPTORS and Jürg Gertsch THE CB1 RECEPTOR ALLOSTERIC MODULATOR, ORG 27569, Maria Grazia Cascio, HAS DIFFERENT EFFECTS ON THE 8.45 Daniele Bolognini POTENCIES WITH WHICH CP55940, 22 and Roger G. Pertwee O-2050 AND SR141716A DISPLACE [3H]CP55940 OR [3H]SR141716A FROM MOUSE BRAIN CB1 RECEPTORS Derek M. Shore, Dow P. IDENTIFICATION OF THE ORG27569 Hurst, Herb Seltzman, BINDING SITE AT THE CB1 RECEPTOR: Gemma Baillie, 9.00 IMPORTANCE OF K3.28 INTERACTION 23 Ruth Ross, Jahan P. TO THE ORG27569 EFFECT ON BASAL Marcu, Mary Abood SIGNALING and Patricia H. Reggio Michelle Glass, Erin Cawston, Courtney ALLOSTERIC MODULATION OF 9.15 24 Breen, William Redmond HUMAN CB1 RECEPTORS and Mark Connor Eugen Brailoiu, G. Cristina Brailiou, Elena Deliu, FUNCTIONAL INTRACELLULAR 9.30 25 Haleli Sharir, CANNABINOID RECEPTORS Pingwei Zhao and Mary E. Abood Lawrence C. Blume, CANNABINOID RECEPTOR Caroline E. Bass, INTERACTING PROTEIN (CRIP1A) 9.45 George D. Dalton, MODULATES CB1 RECEPTOR 26 Dana E. Selley TRAFFICKING, ACTIVITY and Allyn C. Howlett AND SIGNALING Natasha L Grimsey, UNUSUAL TRAFFICKING OF Duneeshya Gunasekara, CANNABINOID RECEPTOR 2: 10.00 Erin Cawston, 27 AGONIST-INDUCED UPREGULATION Catherine E Goodfellow OF SURFACE RECEPTORS and Michelle Glass 21 NOVEL N-ACYL AMIDES, Heather B. Bradshaw, INCLUDING N-DOCOSAHEXEANOYL 10.15 Siham Raboune ETHANOLAMINE, HAVE ACTIVITY AT 28 and Jordyn M. Stuart TRPV1-4 THE PUTATIVE IONOTROPIC CANNABINOID RECEPTORS Christopher J. Fowler, ASSOCIATION BETWEEN TUMOUR 10.30 Peter Hammarsten and PAKT AND CB1 RECEPTOR EXPRESSION 29 Mariateresa Cipriano IN PROSTATE CANCER 10.45 Coffee Break Oral Session 5. Gastrointestinal regulation CHAIRS: STEVEN KINSEY AND MARIO VAN DER STELT REMARKABLE POTENCY OF ∆9-THC IN Steven G. Kinsey, BLOCKING GASTRIC HEMORRHAGES 11.00 Erica C. Cole 30 CAUSED BY CYCLOOXYGENASE and Aron H. Lichtman
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    cancers Review Lipid metabolic Reprogramming: Role in Melanoma Progression and Therapeutic Perspectives 1, 1, 1 2 1 Laurence Pellerin y, Lorry Carrié y , Carine Dufau , Laurence Nieto , Bruno Ségui , 1,3 1, , 1, , Thierry Levade , Joëlle Riond * z and Nathalie Andrieu-Abadie * z 1 Centre de Recherches en Cancérologie de Toulouse, Equipe Labellisée Fondation ARC, Université Fédérale de Toulouse Midi-Pyrénées, Université Toulouse III Paul-Sabatier, Inserm 1037, 2 avenue Hubert Curien, tgrCS 53717, 31037 Toulouse CEDEX 1, France; [email protected] (L.P.); [email protected] (L.C.); [email protected] (C.D.); [email protected] (B.S.); [email protected] (T.L.) 2 Institut de Pharmacologie et de Biologie Structurale, CNRS, Université Toulouse III Paul-Sabatier, UMR 5089, 205 Route de Narbonne, 31400 Toulouse, France; [email protected] 3 Laboratoire de Biochimie Métabolique, CHU Toulouse, 31059 Toulouse, France * Correspondence: [email protected] (J.R.); [email protected] (N.A.-A.); Tel.: +33-582-7416-20 (J.R.) These authors contributed equally to this work. y These authors jointly supervised this work. z Received: 15 September 2020; Accepted: 23 October 2020; Published: 27 October 2020 Simple Summary: Melanoma is a devastating skin cancer characterized by an impressive metabolic plasticity. Melanoma cells are able to adapt to the tumor microenvironment by using a variety of fuels that contribute to tumor growth and progression. In this review, the authors summarize the contribution of the lipid metabolic network in melanoma plasticity and aggressiveness, with a particular attention to specific lipid classes such as glycerophospholipids, sphingolipids, sterols and eicosanoids.
  • (12) Patent Application Publication (10) Pub. No.: US 2012/0022039 A1 Schwink Et Al

    (12) Patent Application Publication (10) Pub. No.: US 2012/0022039 A1 Schwink Et Al

    US 20120022039A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2012/0022039 A1 Schwink et al. (43) Pub. Date: Jan. 26, 2012 (54) NOVEL SUBSTITUTED INDANES, METHOD Publication Classification FOR THE PRODUCTION THEREOF, AND USE (51) Int. Cl. THEREOF AS DRUGS A 6LX 3L/397 (2006.01) C07D 207/06 (2006.01) C07D 2L/22 (2006.01) C07D 22.3/04 (2006.01) (75) Inventors: Lothar Schwink, Frankfurt am C07D 22L/22 (2006.01) Main (DE); Siegfried Stengelin, C07C 235/54 (2006.01) Frankfurt am Main (DE); Matthias C07D 307/14 (2006.01) Gossel, Frankfurt am Main (DE); A63L/35 (2006.01) Klaus Wirth, Frankfurt am Main A6II 3/40 (2006.01) (DE) A6II 3/445 (2006.01) A6II 3/55 (2006.01) A63L/439 (2006.01) A6II 3/66 (2006.01) (73) Assignee: SANOFI, Paris (FR) A6II 3/34 (2006.01) A6IP3/10 (2006.01) A6IP3/04 (2006.01) A6IP3/06 (2006.01) (21) Appl. No.: 13/201410 A6IPL/I6 (2006.01) A6IP3/00 (2006.01) C07D 309/04 (2006.01) (52) U.S. Cl. .................... 514/210.01; 549/426: 548/578; (22) PCT Filed: Feb. 12, 2010 546/205; 540/484; 546/112:564/176; 549/494; 514/459:514/408: 514/319; 514/212.01; 514/299; 514/622:514/471 (86). PCT No.: PCT/EP2010/051796 (57) ABSTRACT The invention relates to substituted indanes and derivatives S371 (c)(1), thereof, to physiologically acceptable salts and physiologi (2), (4) Date: Oct. 4, 2011 cally functional derivatives thereof, to the production thereof, to drugs containing at least one substituted indane according (30) Foreign Application Priority Data to the invention or derivative thereof, and to the use of the Substituted indanes according to the invention and to deriva Feb.