TH 24 ANNUAL SYMPOSIUM OF THE INTERNATIONAL CANNABINOID RESEARCH SOCIETY BAVENO ITALY JUNE 28 - JULY 3, 2014 PRELIMINARY PROGRAMME TH 24 ANNUAL SYMPOSIUM OF THE INTERNATIONAL CANNABINOID RESEARCH SOCIETY BAVENO JUNE 28 – JULY 3, 2014 ICRS Sponsors Government Sponsors National Institute on Drug Abuse Non- Profit Organization Sponsors Kang Tsou Memorial Fund 2014 Symposium on the Cannabinoids Conference Coordinators Cecilia Hillard, Ph.D. Daniela Parolaro, Ph.D. Tiziana Rubino, Ph.D. Ethan Russo, M.D. Jason Schechter, Ph.D. Programme Committee Steve Alexander, Ph.D. Tiziana Bisogno, Ph.D. Heather B Bradshaw, Ph.D. Vincenzo Di Marzo, Ph.D. Michelle Glass, Ph.D. Matthew Hill, Ph.D Mary Lynch, Ph.D. Mauro Maccarrone, Ph.D. Sean McAllister, Ph.D. Daniela Parolaro, Ph.D. Roger G. Pertwee, M.A., D.Phil., D.Sc. Julian Romero Paredes, Ph.D. Tiziana Rubino, Ph.D. Ethan Russo, M.D. Miriam Schneider, Ph.D. Michelle Sexton, N.D. Ryan Vandrey, Ph.D. Jenny Wiley, Ph.D. Committee on Awards Steve Kinsey, Ph.D., Chair Sachin Patel, M.D., Ph.D. Student Award Committee Chair Eliot Gardner, Ph.D. Mechoulam Award Committee Francis Barth, Ph.D. Benjamin Cravatt, Ph.D. Vincenzo Di Marzo, Ph.D. Cecilia Hillard, Ph.D. Allyn Howlett, Ph.D. John Huffman, Ph.D. George Kunos, M.D., Ph.D. Gerard Le Fur, Ph.D. Aron Lichtman, Ph.D. Ken Mackie, M.D. Alex Makriyannis, Ph.D. Roger Pertwee, D.Phil, D.Sc. Raj Razdan, Ph.D. Patti Reggio, Ph.D. Murielle Rinaldi- Carmona, Ph.D. 2014 ICRS Board of Directors Executive Director Cecilia Hillard, Ph.D. President Ethan Russo, M.D. President- Elect Stephen Alexander, Ph.D. Past President Jenny Wiley, Ph.D. Secretary Steve Kinsey, Ph.D. Treasurer Mary Abood, Ph.D. International Secretary Roger Pertwee, M.a., D.Phil, D.Sc. Newsletter Editor Brian Thomas, Ph.D. Student Representative Tiffany Lee Managing Director Jason Schechter, Ph.D. Registration: June 28th, 2014 (16.00 – 18.00) Welcome Reception: 18.30 – 20.00 Day 1 Sunday, June 29th 7.00 Breakfast 8.15 Welcome and Opening Remarks Oral Session 1. Cannabinoids and Pathophysiology CHAIRS: STEVE ALEXANDER AND MAURO MACCARRONE Fabio Arturo Iannotti, STUDY OF THE EXPRESSION PROFILE Enrico Mazzarella, AND PHARMACOLOGICAL ROLE OF THE Ester Pagano, CB1 RECEPTOR IN DUCHENNE 8.30 MUSCULAR DYSTROPHY (DMD) 1 Elisabetta Gazzero, MUSCLES: A NEW OPPORTUNITY TO Raffaele Capasso REINFORCE MUSCLE REPAIR AND and Vincenzo Di Marzo LOCOMOTOR ACTIVITY PALMITOYLETHANOLAMIDE IN A RAT MODEL OF OSTEOARTHRITIS: Giulia Donvito ITS ANTI-INFLAMMATORY AND 8.45 2 and Barbara Costa ANTINOCICEPTIVE EFFECTIVENESS IN COMPARISON WITH NIMESULIDE AND ACETAMINOPHEN Marie-Chantal Larose, Caroline Turcotte, MECHANISMS OF HUMAN Cyril Martin, EOSINOPHIL MIGRATION INDUCED 9.00 3 Véronique Provost, BY THE ENDOCANNABINOID Michel Laviolette 2-ARACHIDONOYL-GLYCEROL and Nicolas Flamand Irina Bronova, PERIPHERAL TARGETING OF Katalin Erdelyi, Alex CB1 CANNABINOID RECEPTORS 9.15 4 Makriyannis, Pal Pacher PROTECTS FROM RADIATION- and Evgeny Berdyshev INDUCED PULMONARY FIBROSIS Daniel J. Hermanson, ENDOCANNABINOID Shu Xu, Naoko Brown, AUGMENTATION BY SUBSTRATE- 9.30 Jeffrey Reese, SELECTIVE COX - 2 INHIBITORS: 5 Sachin Patel MECHANISM AND IN VIVO PROBE and Lawrence J. Marnett DEVELOPMENT James Brodie, THE THERAPEUTIC HANDSHAKE: 9.45 Vincenzo Di Marzo CRAFTING MEDICINES FOR 6 and Geoffrey Guy COMPLEX MALADIES 10.00 Coffee Break PROTECTIVE ROLE OF Shimon Ben-Shabat, THE CANNABINOID RECEPTOR Shiela Hauzner, 10.30 SYSTEM IN AN IN VITRO MODEL 7 Mor Cohen OF AGE-RELATED MACULAR and Elie Beit-Yannai DEGENERATION (AMD) Ariana Foinquinos, Katharina Schimmel, Jan THE CANNABINOID-1 RECEPTOR 10.45 8 Fiedler, Thomas Thum IN CARDIAC FIBROSIS and Sandor Batkai THE ENDOCANNABINOID Kevin Wilhelmsen, N-ARACHIDONOYL DOPAMINE Samira Khakpour, 11.00 (NADA) AND WIN55,212-2 MODULATE 9 Alphonso Tran THE INFLAMMATORY ACTIVATION and Judith Hellman OF HUMAN ENDOTHELIAL CELLS Tamás Bíró, Attila Oláh, NOVEL INHIBIORS OF FATTY Dóra Bodnár, Lídia ACID AMIDE HYDROLASE Ambrus, Attila G. EXERT REMARKABLE ANTI- 11.15 Szöllősi, Nikolett Vasas, 10 INFLAMMATORY EFFECTS BOTH IN Judit Szabó-Papp, Ralf VITRO IN HUMAN KERATINOCYTES Paus, Michael Soeberdt AND IN VIVO IN NC/TND MICE and Christoph Abels Saja Baraghithy, Reem Smoum, STIMULATION OF BONE MASS 11.30 Malka Attar-Namdar, BY A NOVEL METHYLATED 11 Raphael Mechoulam OLEOYL SERINE DERIVATIVE and Itai Bab 12.00 Lunch 13.00 - 15.00 Poster Session 1 P1 Presidential Plenary Speaker CANNABINOIDS REVISITED? NEW TARGETS, CHEMISTRY AND PLANT SOURCES 15.00 Giovanni Appendino, Ph.D. Professor of Organic Chemistry, Università del Piemonte Orientale Department of Pharmaceutical Sciences, Novara, Italy 16.00 Coffee Break Oral Session 2. Pain and TRPs CHAIRS: TIZIANA BISOGNO AND MARY LYNCH Jenny Wilkerson, DIACYLGLYCEROL LIPASE Sudeshna Ghosh, BETA: NEW EVIDENCE 16.30 Ku-Lung Hsu, 12 FOR INFLAMMATORY AND Benjamin F. Cravatt NEUROPATHIC PAIN RELIEF IN MICE and Aron H. Lichtman POSITIVE ALLOSTERIC Richard A. Slivicki, MODULATION OF CB1 WITH GAT211 Liting Deng, Pushkar M. SUPPRESSES PACLITAXEL-INDUCED Kulkarni, Maria Cascio, 16.45 NEUROPATHIC PAIN WHILE 13 Roger G. Pertwee, BYPASSING UNWANTED SIDE Ganesh A. Thakur and EFFECTS OF CB1 RECEPTOR Andrea G. Hohmann ACTIVATION Miren-Josune Canduela, ANATOMY AND FUNCTIONAL Juan-Luis Mendizabal- ROLE OF THE TRANSIENT RECEPTOR Zubiaga, Amanda Sierra, POTENTIAL VANILLOID TYPE 1 IN 17.00 Naiara Royo, 14 THE DENTATE GYRUS OF A Sara Peñasco, Leire KAINATE-INDUCED SEIZURES Reguero, Nagore Puente MOUSE MODEL and Pedro Grandes OVEREXPRESSION OF TRPV1 IN HEK Heather B Bradshaw, CELLS DRIVES DRAMATIC CHANGES Emma Lieshman, IN BASAL ENDOCANNABINOIDS AND 17.15 15 Jordyn M Stuart RELATED LIPIDS WHICH ARE and Mark Connor POTENTIATED WITH STIMULATION BY CAPSAICIN Oral Session 3. Developmental CHAIRS: TIZIANA RUBINO AND SARA JANE WARD Valerio Chiurchiù, ANANDAMIDE REGULATES Alessandro Leuti, MATURATION AND FUNCTION 17.30 16 Emanuela Talamonti OF HUMAN MONOCYTE-DERIVED and Mauro Maccarrone DENDRITIC CELLS LEARNING UNDER Maria Morena, Andrea STRESS DIFFERENTIALLY Peloso, Viviana Trezza, 17.45 AFFECTS CANNABINOID 17 Matthew N. Hill MODULATION OF SPATIAL and Patrizia Campolongo MEMORY RETRIEVAL IN RATS Piray Atsak, Daniela Hauer, THE ROLE OF ENDOCANNABINOID Patrizia Campolongo, SIGNALING IN MEDIATING EFFECTS 18.00 18 Gustav Schelling, OF SEVERAL STRESS SYSTEMS IN Raquel V Fornari MEMORY CONSOLIDATION and Benno Roozendaal Andrea Martella, Rosa Maria Sepe, FUNCTIONAL CHARACTERIZATION Cristoforo Silvestri, OF THE ENDOCANNABINOID SYSTEM 18.15 19 Oliana Carnevali, DURING ZEBRAFISH (DANIO RERIO) Paolo Sordino EMBRYONIC DEVELOPMENT and Vincenzo Di Marzo EFFECTS OF DELETIONS IN FAAH Emma Leishman, ON THE ENDOCANNABINOID 18.30 Ben Cornett, Ken Mackie AND WIDE-RANGING-RELATED 20 and Heather B Bradshaw LIPIDOME IN EIGHT REGIONS OF THE MOUSE BRAIN Oral Session 4. Cannabinoids and Cancer CHAIRS: TIZIANA RUBINO AND SARA JANE WARD Paula Morales, NOVEL CB2 SELECTIVE Sandra Blasco-Benito, CANNABINOID-ORTHOQUINONES María Gómez-Cañas, EFFECTIVE FOR THE TREATMENT 18.45 Pilar Goya, 21 OF TRIPLE NEGATIVE BREAST Javier Fernández-Ruiz, CANCER AND LACKING Cristina Sánchez NON-TUMOR CELL TOXICITY and Nadine Jagerovic Christopher J. Fowler, IDENTIFYING POTENTIAL Jenny Häggström, UPSTREAM REGULATORS OF 19.00 22 Mariateresa Cipriano THE ENDOCANNABINOID SYSTEM and Peter Hammarsten IN PROSTATE CANCER 19.30 Dinner Day 2 Monday, June 30th 7.00 Breakfast Oral Session 5. Cannabinoid Receptors and Signaling CHAIRS: MICHELLE GLASS AND NEPHI STELLA BETA-ARRESTIN2 APPEARS TO MEDIATE THE ACTIVITY Chris Breivogel 8.30 OF CANNABINOIDS IN FEMALE 23 and Ankita Gupta MICE IN A MANNER THAT DIFFERS FROM MALES Nilushi Karunaratne, Paul J White, Stewart SIGNALLING PROFILE OF CRIP1a: 8.45 Fabb, Meritxell Canals, G - PROTEIN ACTIVATION AND 24 Mark Connor SIGNAL TRANSDUCTION and Daniel T Malone Etienne Hebert- Chatelain, Tifany Desprez, Edgar Soria, Luigi Bellocchio, Anna Delamarre, Arnau Busquets-Garcia, Laurie MITOCHONDRIAL CANNABINOID Robin, Nagore Puente, RECEPTORS MEDIATE SPECIFIC 9.00 25 Jean-William Dupuy, EFFECTS OF CANNABINOIDS VIA Uzaskun Elezgarai, SOLUBLE ADENYLYL CYCLASE (sAC) Rodrigue Rossignol, Federico Massa, Pedro Grandes, Giovanni Bénard and Giovanni Marsicano MOLECULAR DYNAMICS STUDY OF Derek M. Shore, A CB1 ENDOGENOUS ALLOSTERIC Diane L. Lynch, 9.15 MODULATOR, LIPOXIN A4: DYNAMIC 26 Michael C. Pitman BEHAVIOR IN A LIPID BILAYER AND and Patricia H. Reggio ENTRANCE INTO THE CB1 RECEPTOR Alipi V. Naydenov, GENETIC RESCUE OF Marja Sepers, CB1 RECEPTORS ON MEDIUM Katie Swinney, SPINY NEURONS PREVENTS 9.30 27 Lynn Raymond, LOSS OF EXCITATORY STRIATAL Richard Palmiter SYNAPSES BUT NOT MOTOR and Nephi Stella PHENOTYPE IN R6/2 MICE Martin Kaczocha, FATTY ACID BINDING Matthew W. Elmes, PROTEINS (FABPS) William T. Berger, 9.45 ARE INTRACELLULAR CARRIERS 28 KwanNok Leung, FOR ∆9-TETRAHYDROCANNABINOL Iwao Ojima (THC) AND CANNABIDIOL (CBD) and Dale G. Deutsch Michelle Glass, FUNCTIONAL SELECTIVITY IN 10.00 Courtney M Breen CB1R PHARMACODYNAMICS – 29 and Mark Connor OCCUPANCY, EFFICACY AND TIME 10.15 Coffee Break Oral Session 6. Cannabis Use and Abuse Issues CHAIRS: ZIVA COOPER AND RYAN VANDREY Maju Mathew Koola, Hailey E. Turner, CANNABIS WITHDRAWAL IN 10.45 Deanna L. Kelly, Fang 30 ADULTS WITH MOOD DISORDERS Liu, Jared A. Linthicum and David A. Gorelick Zheng-Xiong Xi, Pretal Muldoon, EFFECTS OF Xiao-Fei Wang, Guo- Δ8-TETRAHYDROCANNABIVARIN 11.00 Hua Bi, M. Imad Damaj, (Δ8-THCV) ON APPETITIVE 31 Aron H. Lichtman, EFFECTS OF COCAINE Roger G. Pertwee