1022-Historia Da Ciencia - Vol.III
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RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA
GENES AND PROTEINS THAT CONTROL THE SECRETORY PATHWAY Nobel Lecture, 7 December 2013 by RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA. Introduction George Palade shared the 1974 Nobel Prize with Albert Claude and Christian de Duve for their pioneering work in the characterization of organelles interrelated by the process of secretion in mammalian cells and tissues. These three scholars established the modern field of cell biology and the tools of cell fractionation and thin section transmission electron microscopy. It was Palade’s genius in particular that revealed the organization of the secretory pathway. He discovered the ribosome and showed that it was poised on the surface of the endoplasmic reticulum (ER) where it engaged in the vectorial translocation of newly synthesized secretory polypeptides (1). And in a most elegant and technically challenging investigation, his group employed radioactive amino acids in a pulse-chase regimen to show by autoradiograpic exposure of thin sections on a photographic emulsion that secretory proteins progress in sequence from the ER through the Golgi apparatus into secretory granules, which then discharge their cargo by membrane fusion at the cell surface (1). He documented the role of vesicles as carriers of cargo between compartments and he formulated the hypothesis that membranes template their own production rather than form by a process of de novo biogenesis (1). As a university student I was ignorant of the important developments in cell biology; however, I learned of Palade’s work during my first year of graduate school in the Stanford biochemistry department. -
USA Education Ph.D., Biology, Massachusetts Institute of Tech
Victor R. Ambros, Ph.D. Silverman Professor of Natural Sciences Program in Molecular Medicine University of Massachusetts Medical School373 Plantation Street, Suite 306 Worcester, MA 01605 (508) 856-6380 [email protected] Personal Born: Hanover, NH, USA on December 1, 1953 Citizenship: USA Education Ph.D., Biology, Massachusetts Institute of Technology, Cambridge, MA 1976-1979 Thesis Title: The protein covalently linked to the 5' end of poliovirus RNA Advisor: Dr. David Baltimore B.S., Biology, Massachusetts Institute of Technology, Cambridge, MA 1971-1975 Professional Appointments Silverman Professor of Natural Sciences 2009-present Co-Director, RNA Therapeutics Institute 2009-2016 Professor, Program in Molecular Medicine 2008-present University of Massachusetts Medical School, Worcester, MA Professor of Genetics, Dartmouth Medical School 2001-2007 Professor, Biological Sciences, Dartmouth Medical School 1996-2001 Associate Professor, Biological Sciences, Dartmouth Medical School 1992-1996 Associate Professor, Department of Cellular and Development Biology, 1988-1992 Harvard University, Cambridge, MA Assistant Professor, Department of Cellular and Development Biology, 1985-1988 Harvard University, Cambridge, MA Postdoctoral Research 1979-1985 Supervisor: Dr. H. Robert Horvitz Massachusetts Institute of Technology, Cambridge, MA Graduate Research 1976-1979 Supervisor: Dr. David Baltimore Massachusetts Institute of Technology, Cambridge, MA Research Assistant 1975-1976 Supervisor: Dr. David Baltimore Center for Cancer Research, -
2016-2017 Year Book Www
1 2016-2017 YEAR BOOK WWW. C A R N E G I E S C I E N C E . E D U Department of Embryology 3520 San Martin Dr. / Baltimore, MD 21218 410.246.3001 Geophysical Laboratory 5251 Broad Branch Rd., N.W. / Washington, DC 20015-1305 202.478.8900 Department of Global Ecology 260 Panama St. / Stanford, CA 94305-4101 650.462.1047 The Carnegie Observatories 813 Santa Barbara St. / Pasadena, CA 91101-1292 626.577.1122 Las Campanas Observatory Casilla 601 / La Serena, Chile Department of Plant Biology 260 Panama St. / Stanford, CA 94305-4101 650.325.1521 Department of Terrestrial Magnetism 5241 Broad Branch Rd., N.W. / Washington, DC 20015-1305 202.478.8820 Office of Administration 1530 P St., N.W. / Washington, DC 20005-1910 202.387.6400 2 0 1 6 - 2 0 1 7 Y E A R B O O K The President’s Report July 1, 2016 - June 30, 2017 C A R N E G I E I N S T I T U T I O N F O R S C I E N C E Former Presidents Daniel C. Gilman, 1902–1904 Robert S. Woodward, 1904–1920 John C. Merriam, 1921–1938 Vannevar Bush, 1939–1955 Caryl P. Haskins, 1956–1971 Philip H. Abelson, 1971–1978 James D. Ebert, 1978–1987 Edward E. David, Jr. (Acting President, 1987–1988) Maxine F. Singer, 1988–2002 Michael E. Gellert (Acting President, Jan.–April 2003) Richard A. Meserve, 2003–2014 Former Trustees Philip H. Abelson, 1978–2004 Patrick E. -
Wave Nature of Matter: Made Easy (Lesson 3) Matter Behaving As a Wave? Ridiculous!
Wave Nature of Matter: Made Easy (Lesson 3) Matter behaving as a wave? Ridiculous! Compiled by Dr. SuchandraChatterjee Associate Professor Department of Chemistry Surendranath College Remember? I showed you earlier how Einstein (in 1905) showed that the photoelectric effect could be understood if light were thought of as a stream of particles (photons) with energy equal to hν. I got my Nobel prize for that. Louis de Broglie (in 1923) If light can behave both as a wave and a particle, I wonder if a particle can also behave as a wave? Louis de Broglie I’ll try messing around with some of Einstein’s formulae and see what I can come up with. I can imagine a photon of light. If it had a “mass” of mp, then its momentum would be given by p = mpc where c is the speed of light. Now Einstein has a lovely formula that he discovered linking mass with energy (E = mc2) and he also used Planck’s formula E = hf. What if I put them equal to each other? mc2 = hf mc2 = hf So for my photon 2 mp = hfhf/c/c So if p = mpc = hfhf/c/c p = mpc = hf/chf/c Now using the wave equation, c = fλ (f = c/λ) So mpc = hc /λc /λc= h/λ λ = hp So you’re saying that a particle of momentum p has a wavelength equal to Planck’s constant divided by p?! Yes! λ = h/p It will be known as the de Broglie wavelength of the particle Confirmation of de Broglie’s ideas De Broglie didn’t have to wait long for his idea to be shown to be correct. -
書 名 等 発行年 出版社 受賞年 備考 N1 Ueber Das Zustandekommen Der
書 名 等 発行年 出版社 受賞年 備考 Ueber das Zustandekommen der Diphtherie-immunitat und der Tetanus-Immunitat bei thieren / Emil Adolf N1 1890 Georg thieme 1901 von Behring N2 Diphtherie und tetanus immunitaet / Emil Adolf von Behring und Kitasato 19-- [Akitomo Matsuki] 1901 Malarial fever its cause, prevention and treatment containing full details for the use of travellers, University press of N3 1902 1902 sportsmen, soldiers, and residents in malarious places / by Ronald Ross liverpool Ueber die Anwendung von concentrirten chemischen Lichtstrahlen in der Medicin / von Prof. Dr. Niels N4 1899 F.C.W.Vogel 1903 Ryberg Finsen Mit 4 Abbildungen und 2 Tafeln Twenty-five years of objective study of the higher nervous activity (behaviour) of animals / Ivan N5 Petrovitch Pavlov ; translated and edited by W. Horsley Gantt ; with the collaboration of G. Volborth ; and c1928 International Publishing 1904 an introduction by Walter B. Cannon Conditioned reflexes : an investigation of the physiological activity of the cerebral cortex / by Ivan Oxford University N6 1927 1904 Petrovitch Pavlov ; translated and edited by G.V. Anrep Press N7 Die Ätiologie und die Bekämpfung der Tuberkulose / Robert Koch ; eingeleitet von M. Kirchner 1912 J.A.Barth 1905 N8 Neue Darstellung vom histologischen Bau des Centralnervensystems / von Santiago Ramón y Cajal 1893 Veit 1906 Traité des fiévres palustres : avec la description des microbes du paludisme / par Charles Louis Alphonse N9 1884 Octave Doin 1907 Laveran N10 Embryologie des Scorpions / von Ilya Ilyich Mechnikov 1870 Wilhelm Engelmann 1908 Immunität bei Infektionskrankheiten / Ilya Ilyich Mechnikov ; einzig autorisierte übersetzung von Julius N11 1902 Gustav Fischer 1908 Meyer Die experimentelle Chemotherapie der Spirillosen : Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie / N12 1910 J.Springer 1908 von Paul Ehrlich und S. -
Ira Sprague Bowen Papers, 1940-1973
http://oac.cdlib.org/findaid/ark:/13030/tf2p300278 No online items Inventory of the Ira Sprague Bowen Papers, 1940-1973 Processed by Ronald S. Brashear; machine-readable finding aid created by Gabriela A. Montoya Manuscripts Department The Huntington Library 1151 Oxford Road San Marino, California 91108 Phone: (626) 405-2203 Fax: (626) 449-5720 Email: [email protected] URL: http://www.huntington.org/huntingtonlibrary.aspx?id=554 © 1998 The Huntington Library. All rights reserved. Observatories of the Carnegie Institution of Washington Collection Inventory of the Ira Sprague 1 Bowen Papers, 1940-1973 Observatories of the Carnegie Institution of Washington Collection Inventory of the Ira Sprague Bowen Paper, 1940-1973 The Huntington Library San Marino, California Contact Information Manuscripts Department The Huntington Library 1151 Oxford Road San Marino, California 91108 Phone: (626) 405-2203 Fax: (626) 449-5720 Email: [email protected] URL: http://www.huntington.org/huntingtonlibrary.aspx?id=554 Processed by: Ronald S. Brashear Encoded by: Gabriela A. Montoya © 1998 The Huntington Library. All rights reserved. Descriptive Summary Title: Ira Sprague Bowen Papers, Date (inclusive): 1940-1973 Creator: Bowen, Ira Sprague Extent: Approximately 29,000 pieces in 88 boxes Repository: The Huntington Library San Marino, California 91108 Language: English. Provenance Placed on permanent deposit in the Huntington Library by the Observatories of the Carnegie Institution of Washington Collection. This was done in 1989 as part of a letter of agreement (dated November 5, 1987) between the Huntington and the Carnegie Observatories. The papers have yet to be officially accessioned. Cataloging of the papers was completed in 1989 prior to their transfer to the Huntington. -
Famous Physicists Himansu Sekhar Fatesingh
Fun Quiz FAMOUS PHYSICISTS HIMANSU SEKHAR FATESINGH 1. The first woman to 6. He first succeeded in receive the Nobel Prize in producing the nuclear physics was chain reaction. a. Maria G. Mayer a. Otto Hahn b. Irene Curie b. Fritz Strassmann c. Marie Curie c. Robert Oppenheimer d. Lise Meitner d. Enrico Fermi 2. Who first suggested electron 7. The credit for discovering shells around the nucleus? electron microscope is often a. Ernest Rutherford attributed to b. Neils Bohr a. H. Germer c. Erwin Schrödinger b. Ernst Ruska d. Wolfgang Pauli c. George P. Thomson d. Clinton J. Davisson 8. The wave theory of light was 3. He first measured negative first proposed by charge on an electron. a. Christiaan Huygens a. J. J. Thomson b. Isaac Newton b. Clinton Davisson c. Hermann Helmholtz c. Louis de Broglie d. Augustin Fresnel d. Robert A. Millikan 9. He was the first scientist 4. The existence of quarks was to find proof of Einstein’s first suggested by theory of relativity a. Max Planck a. Edwin Hubble b. Sheldon Glasgow b. George Gamow c. Murray Gell-Mann c. S. Chandrasekhar d. Albert Einstein d. Arthur Eddington 10. The credit for development of the cyclotron 5. The phenomenon of goes to: superconductivity was a. Carl Anderson b. Donald Glaser discovered by c. Ernest O. Lawrence d. Charles Wilson a. Heike Kamerlingh Onnes b. Alex Muller c. Brian D. Josephson 11. Who first proposed the use of absolute scale d. John Bardeen of Temperature? a. Anders Celsius b. Lord Kelvin c. Rudolf Clausius d. -
Simulating Physics with Computers
International Journal of Theoretical Physics, VoL 21, Nos. 6/7, 1982 Simulating Physics with Computers Richard P. Feynman Department of Physics, California Institute of Technology, Pasadena, California 91107 Received May 7, 1981 1. INTRODUCTION On the program it says this is a keynote speech--and I don't know what a keynote speech is. I do not intend in any way to suggest what should be in this meeting as a keynote of the subjects or anything like that. I have my own things to say and to talk about and there's no implication that anybody needs to talk about the same thing or anything like it. So what I want to talk about is what Mike Dertouzos suggested that nobody would talk about. I want to talk about the problem of simulating physics with computers and I mean that in a specific way which I am going to explain. The reason for doing this is something that I learned about from Ed Fredkin, and my entire interest in the subject has been inspired by him. It has to do with learning something about the possibilities of computers, and also something about possibilities in physics. If we suppose that we know all the physical laws perfectly, of course we don't have to pay any attention to computers. It's interesting anyway to entertain oneself with the idea that we've got something to learn about physical laws; and if I take a relaxed view here (after all I'm here and not at home) I'll admit that we don't understand everything. -
Nature Medicine Essay
COMMENTARY LASKER BASIC MEDICAL RESEARCH AWARD Of maize and men, or peas and people: case histories to justify plants and other model systems David Baulcombe One of the byproducts of molecular biology cork is altogether filled with air, and that air is has been support for the ‘model system’ con- perfectly enclosed in little boxes or cells distinct cept. All living organisms are based on the same from one another.”)2 (Fig. 1). Two hundred fifty genetic code, they have similar subcellular years later, Beijerinck discovered a contagium structures and they use homologous metabolic vivum fluidum in extracts of diseased tobacco pathways. So, mechanisms can be investigated plants that he later referred to as a virus3. using organisms other than those in which In contemporary science, a green alga— the knowledge will be exploited for practical Chlamydomonas reinhardtii—is a useful model benefit. Model systems are particularly use- in the analysis of kidney disease4. However, ful in the early discovery phase of a scientific in this article, I refer to the contribution of endeavor, and recent progress in biomedical plant biology to a family of mechanisms that I science has fully vindicated their use. Jacques refer to as RNA silencing. This topic has been Monod, for example, famously justified his reviewed comprehensively elsewhere5,6, so here work on a bacterial model system by stating I focus on personal experience and my view of that “what is true for Escherichia coli is also future potential from this work. true for elephants.” My fellow laureates, Victor Ambros and Gary Ruvkun, can defend the use The early history of RNA silencing in of the worm Caenorhabditis elegans as a good plants model system and so I will focus on plants. -
Introduction and Historical Perspective
Chapter 1 Introduction and Historical Perspective “ Nothing in biology makes sense except in the light of evolution. ” modified by the developmental history of the organism, Theodosius Dobzhansky its physiology – from cellular to systems levels – and by the social and physical environment. Finally, behaviors are shaped through evolutionary forces of natural selection OVERVIEW that optimize survival and reproduction ( Figure 1.1 ). Truly, the study of behavior provides us with a window through Behavioral genetics aims to understand the genetic which we can view much of biology. mechanisms that enable the nervous system to direct Understanding behaviors requires a multidisciplinary appropriate interactions between organisms and their perspective, with regulation of gene expression at its core. social and physical environments. Early scientific The emerging field of behavioral genetics is still taking explorations of animal behavior defined the fields shape and its boundaries are still being defined. Behavioral of experimental psychology and classical ethology. genetics has evolved through the merger of experimental Behavioral genetics has emerged as an interdisciplin- psychology and classical ethology with evolutionary biol- ary science at the interface of experimental psychology, ogy and genetics, and also incorporates aspects of neuro- classical ethology, genetics, and neuroscience. This science ( Figure 1.2 ). To gain a perspective on the current chapter provides a brief overview of the emergence of definition of this field, it is helpful -
List of Members
LIST OF MEMBERS, ALFRED BAKER, M.A., Professor of Mathematics, University of Toronto, Toronto, Canada. ARTHUR LATHAM BAKER, C.E., Ph.D., Professor of Mathe matics, Stevens School, Hpboken., N. J. MARCUS BAKER, U. S. Geological Survey, Washington, D.C. JAMES MARCUS BANDY, B.A., M.A., Professor of Mathe matics and Engineering, Trinit)^ College, N. C. EDGAR WALES BASS, Professor of Mathematics, U. S. Mili tary Academy, West Point, N. Y. WOOSTER WOODRUFF BEMAN, B.A., M.A., Member of the London Mathematical Society, Professor of Mathe matics, University of Michigan, Ann Arbor, Mich. R. DANIEL BOHANNAN, B.Sc, CE., E.M., Professor of Mathematics and Astronomy, Ohio State University, Columbus, Ohio. CHARLES AUGUSTUS BORST, M.A., Assistant in Astronomy, Johns Hopkins University, Baltimore, Md. EDWARD ALBERT BOWSER, CE., LL.D., Professor of Mathe matics, Rutgers College, New Brunswick, N. J. JOHN MILTON BROOKS, B.A., Instructor in Mathematics, College of New Jersey, Princeton, N. J. ABRAM ROGERS BULLIS, B.SC, B.C.E., Macedon, Wayne Co., N. Y. WILLIAM ELWOOD BYERLY, Ph.D., Professor of Mathematics, Harvard University, Cambridge*, Mass. WILLIAM CAIN, C.E., Professor of Mathematics and Eng ineering, University of North Carolina, Chapel Hill, N. C. CHARLES HENRY CHANDLER, M.A., Professor of Mathe matics, Ripon College, Ripon, Wis. ALEXANDER SMYTH CHRISTIE, LL.M., Chief of Tidal Division, U. S. Coast and Geodetic Survey, Washington, D. C. JOHN EMORY CLARK, M.A., Professor of Mathematics, Yale University, New Haven, Conn. FRANK NELSON COLE, Ph.D., Assistant Professor of Mathe matics, University of Michigan, Ann Arbor, Mich. -
DNA: the Timeline and Evidence of Discovery
1/19/2017 DNA: The Timeline and Evidence of Discovery Interactive Click and Learn (Ann Brokaw Rocky River High School) Introduction For almost a century, many scientists paved the way to the ultimate discovery of DNA and its double helix structure. Without the work of these pioneering scientists, Watson and Crick may never have made their ground-breaking double helix model, published in 1953. The knowledge of how genetic material is stored and copied in this molecule gave rise to a new way of looking at and manipulating biological processes, called molecular biology. The breakthrough changed the face of biology and our lives forever. Watch The Double Helix short film (approximately 15 minutes) – hyperlinked here. 1 1/19/2017 1865 The Garden Pea 1865 The Garden Pea In 1865, Gregor Mendel established the foundation of genetics by unraveling the basic principles of heredity, though his work would not be recognized as “revolutionary” until after his death. By studying the common garden pea plant, Mendel demonstrated the inheritance of “discrete units” and introduced the idea that the inheritance of these units from generation to generation follows particular patterns. These patterns are now referred to as the “Laws of Mendelian Inheritance.” 2 1/19/2017 1869 The Isolation of “Nuclein” 1869 Isolated Nuclein Friedrich Miescher, a Swiss researcher, noticed an unknown precipitate in his work with white blood cells. Upon isolating the material, he noted that it resisted protein-digesting enzymes. Why is it important that the material was not digested by the enzymes? Further work led him to the discovery that the substance contained carbon, hydrogen, nitrogen and large amounts of phosphorus with no sulfur.