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NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No. A Location : Canada

LC‐MS/MS Human 1 Acetaminophen 0.1 to 13 µg / mL K EDTA ‐ (API 300 or 3000) Plasma 2 LC‐MS/MS Human 2 Acetaminophen 0.1 to 13 µg / mL K EDTA 320 mg (Waters QPXE) Plasma 2 Human 3 Acyclovir HPLC‐UV 5 to 1280 ng / mL Heparin ‐ Plasma HPLC Human Sodium 4 Acyclovir 10 to 2560 ng / mL ‐ ‐ Flurosence Plasma heparin HPLC Human Sodium 5 Acyclovir 20 to 2560 ng / mL ‐ Flurosence Plasma heparin LC‐MS/MS Human 6 Acyclovir 5 to 1600 ng / mL K EDTA 200 mg (Thermo) Plasma 2 LC‐MS/MS Human 7Alverine 0.05 to 10 ng / mL K EDTA 120 mg (Thermo) Plasma 2 LC‐MS/MS Human 8 Allopurinol 10 to 5000 ng/mL K EDTA 200 mg (Thermo) Plasma 2 LC‐MS/MS Human 9Amantadine 2 to 1500 ng / mL K EDTA 300mg (Waters QPXE) Plasma 2 LC‐MS/MS Human Not 10 20 to 3000 ng / mL 160 mg (Thermo) Urine applicable LC‐MS/MS Human 0.4 to 51 ng / mL K EDTA ‐ (API 3000) Plasma 2 11 LC‐MS/MS Human 0.4 to 51 ng / mL K EDTA ‐ (API 3000) Plasma 2 LC‐MS/MS Human 12 Amlodipine 0.1 to 13 ng / mL K EDTA 10 mg (API 3000) Plasma 3 LC‐MS/MS Human D‐ 0.5 to 100 ng / mL K EDTA (API 6500) Plasma 2 13 30 mg LC‐MS/MS Human L‐Amphetamine 0.15 to 30 ng/mL K EDTA (API 6500) Plasma 2 LC‐MS/MS Human 14 Amphotericin B 5 to 5000 ng / mL K EDTA 200 to 400 mg (Waters QPXE) Plasma 2 LC‐MS/MS Human 15 Alectinib 1 to 600 ng/mL K EDTA 50mg (Thermo) Plasma 2 LC‐MS/MS Human 16 Alectinib 1 to 600 ng/mL K EDTA 150 mg (Thermo) Plasma 2 LC‐MS/MS Human Not 17 Alendronate 1 to 256 ng / mL ‐ (API 3000) Urine applicable NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human 18 Anastrozole 0.1 to 26 ng / mL K EDTA 1 mg (API 3000) Plasma 2 LC‐MS/MS Human 19 0.500 to 500 ng/mL K EDTA 10 mg (Thermo) Plasma 2 LC‐MS/MS Human 20 Atomoxetine 2.5 to 2500 ng/mL K EDTA 60 mg (Thermo) Plasma 2 LC‐MS/MS Human Atomoxetine 2 to 512 ng / mL K EDTA 40 mg (Thermo) Plasma 2 LC‐MS/MS Human 21 4‐Hydroxyatomoxetine 2 to 512 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Human N‐Desmethylatomoxetine 2 to 512 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Human Sodium 22 Atorvastatin 0.3 to 300 ng/mL 80 mg (Thermo) Plasma heparin LC‐MS/MS Human Atorvastatin 0.4 to 102 ng / mL K EDTA 80 mg (Thermo) Plasma 2 LC‐MS/MS Human 23 o‐hydroxyatorvastatin 0.4 to 102.5 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Human p‐hydroxyatorvastatin 0.04 to 10 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Dog Atorvastatin 0.25 to 2500 ng / mL K EDTA 5 mg to 80 mg (Thermo) Plasma 2 LC‐MS/MS Dog o‐hydroxyatorvastatin 0.25 to 500 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Dog p‐hydroxyatorvastatin 0.25 to 500 ng / mL K EDTA ‐ (Thermo) Plasma 2 24 LC‐MS/MS Dog Atorvastatin Lactone 0.5 to 2500 ng / mL K EDTA ‐ (Thermo) Plasma 2 o‐Hydroxy Atorvastatin LC‐MS/MS Dog 0.5 to 250 ng / mL K EDTA ‐ Lactone (Thermo) Plasma 2 p‐Hydroxy Atorvastatin LC‐MS/MS Dog 0.5 to 250 ng / mL K EDTA ‐ Lactone (Thermo) Plasma 2 LC‐MS/MS Dog Atorvastatin 10 to 2500 ng / mL K EDTA 5 mg to 80 mg (Thermo) Plasma 2 LC‐MS/MS Dog o‐hydroxyatorvastatin 1 to 250 ng / mL K EDTA ‐ (Thermo) Plasma 2 25 LC‐MS/MS Dog p‐hydroxyatorvastatin 1 to 250 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Dog Atorvastatin Lactone 10 to 2500 ng / mL K EDTA ‐ (Thermo) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

o‐Hydroxy Atorvastatin LC‐MS/MS Dog 1 to 250 ng / mL K EDTA ‐ Lactone (Thermo) Plasma 2 25 p‐Hydroxy Atorvastatin LC‐MS/MS Dog 1 to 250 ng / mL K EDTA ‐ Lactone (Thermo) Plasma 2 LC‐MS/MS Human Atorvastatin 10 to 15000 pg / mL K EDTA 10 mg (Thermo) Plasma 2 LC‐MS/MS Human 26 o‐Hydroxy Atorvastatin 10 to 10000 pg / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Human p‐Hydroxy Atorvastatin 10 to 5000 pg / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Human Atorvastatin 0.1 to 40 ng / mL K EDTA 20 mg (Thermo) Plasma 2 LC‐MS/MS Human o‐Hydroxy Atorvastatin 0.1 to 40 ng / mL K EDTA ‐ (Thermo) Plasma 2 27 LC‐MS/MS Human p‐Hydroxy Atorvastatin 0.05 to 20 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Human Glimepiride 0.5 to 200 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Human 28 Atazanavir 20 to 8000 ng/mL K EDTA 300 mg (Thermo) Plasma 2 LC‐MS/MS Human 29 Axitinib 0.1 to 100 ng/mL K EDTA 5 mg (Thermo) Plasma 2 LC‐MS Human Sodium 30 Azithromycin 5 to 1280 ng / mL 600 mg (API 150) Plasma heparin B

LC‐MS/MS Human 31 Barnidipine 50 to 10000 ng/mL K EDTA 20 mg (Thermo) Plasma 2

LC‐MS/MS Human 32 Barnidipine 15 to 7000 pg/mL K EDTA 20mg (Thermo) Plasma 2

LC‐MS/MS Human 33 R‐Baclofen 1 to 500 ng / mL K EDTA 10 mg (Thermo) Plasma 2

LC‐MS/MS Human R‐Baclofen 1 to 500 ng / mL K EDTA 20 mg (Thermo) Plasma 2 34 LC‐MS/MS Human S‐Baclofen 1 to 500 ng / mL K EDTA 20 mg (Thermo) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human Not R‐Baclofen 2 to 2000 ng / mL 20 mg (Thermo) Urine applicable 35 LC‐MS/MS Human Not S‐Baclofen 2 to 2000 ng / mL 20 mg (Thermo) Urine applicable

LC‐MS/MS Human Betamethasone 0.5 to 128 ng / mL K EDTA ‐ (Thermo) Plasma 2 36 Betamethasone LC‐MS/MS Human 0.5 to 128 ng / mL K EDTA ‐ Acetate (Thermo) Plasma 2

Betamethasone LC‐MS/MS Human 36 2 to 512 ng / mL K EDTA ‐ Phosphate (Thermo) Plasma 2

LC‐MS/MS Human Sodium 37 Budesonide 20 to 10000 pg/mL 3 x 3 mg (API 6500) Plasma heparin

LC‐MS/MS Human or Sodium 1 to 1023 ng / mL 348 mg (API 3000) Rat Plasma heparin

Bupropion Erythroamino LC‐MS/MS Human or Sodium 1 to 1024 ng / mL ‐ (API 3000) Rat Plasma heparin 38 Bupropion Threoamino LC‐MS/MS Human or Sodium 1 to 1024 ng / mL ‐ Alcohol (API 3000) Rat Plasma heparin

LC‐MS/MS Human or Sodium 3 to 4000 ng / mL ‐ (API 3000) Rat Plasma heparin

LC‐MS/MS Human Sodium Bupropion 1 to 512 ng / mL 174 mg (API 3000) Plasma heparin

Bupropion Erythroamino LC‐MS/MS Human Sodium 1 to 512 ng / mL ‐ Alcohol (API 3000) Plasma heparin 39 Bupropion Threoamino LC‐MS/MS Human Sodium 1 to 512 ng / mL ‐ Alcohol (API 3000) Plasma heparin

LC‐MS/MS Human Sodium Hydroxybupropion 4 to 2000 ng / mL ‐ (API 3000) Plasma heparin

LC‐MS/MS Human Not Bupropion 16 to 1024 ng / mL 174 mg (API 3000) Urine applicable 40 Bupropion Erythroamino LC‐MS/MS Human Not 16 to 1024 ng / mL ‐ Alcohol (API 3000) Urine applicable NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

Bupropion Threoamino LC‐MS/MS Human Not 16 to 1024 ng / mL ‐ Alcohol (API 3000) Urine applicable 40 LC‐MS/MS Human Not Hydroxybupropion 62.5 to 4000 ng / mL ‐ (API 3000) Urine applicable

LC‐MS/MS Rat Sodium Bupropion 5 to 5120 ng / mL ‐ (Thermo) Plasma heparin

Bupropion Erythroamino LC‐MS/MS Rat Sodium 1 to 1024 ng / mL ‐ Alcohol (Thermo) Plasma heparin 41

Bupropion Threoamino LC‐MS/MS Rat Sodium 1 to 1024 ng / mL ‐ Alcohol (Thermo) Plasma heparin LC‐MS/MS Rat Sodium Hydroxybupropion 2 to 2048 ng / mL ‐ (Thermo) Plasma heparin Human LC‐MS/MS Plasma Sodium 0.1 to 25 ng / mL ‐ (API 3000) or Dog heparin Plasma 42 Human LC‐MS/MS Plasma Sodium 0.1 to 25 ng / mL ‐ (API 3000) or Dog heparin Plasma LC‐MS/MS Human Sodium Buprenorphine 25 to 10000 pg / mL 8 mg (API 6500) Plasma heparin 43 LC‐MS/MS Human Sodium Norbuprenorphine 50 to 10000 pg / mL ‐ (API 6500) Plasma heparin LC‐MS/MS Human Sodium (API 300 0.02 to 10 ng / mL ‐ Plasma heparin or 3000) 44 LC‐MS/MS Human Sodium 1‐(2‐Pyrimidyl) (API 300 0.2 to 25 ng / mL ‐ Plasma heparin or 3000) Human LC‐MS/MS Plasma Buspirone 0.4 to 77 ng / mL K EDTA ‐ (API 3000) or Mouse 3 45 Plasma Human LC‐MS/MS Plasma 1‐(2‐Pyrimidyl)Piperazine 1.6 to 307.2 ng / mL K EDTA ‐ (API 3000) or Mouse 3 Plasma NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

Human Plasma or Mouse LC‐MS/MS Plasma Sodium 46 Buspirone 0.05 to 10 ng / mL ‐ (API 3000) or Rat heparin Plasma or Dog Plasma Human Plasma or Mouse LC‐MS/MS Plasma Sodium 46 1‐(2‐Pyrimidyl)Piperazine 0.2 to 38 ng / mL ‐ (API 3000) or Rat heparin Plasma or Dog Plasma Human Plasma LC‐MS/MS or Rat Buspirone (API 300 0.4 to 50 ng / mL Heparin ‐ Plasma or 3000) or Dog Plasma 47 Human Plasma LC‐MS/MS or Rat 1‐(2‐Pyrimidyl) Piperazine (API 300 0.4 to 50 ng / mL Heparin ‐ Plasma or 3000) or Dog Plasma LC‐MS/MS Human Sodium Buspirone 0.04 to 10 ng / mL ‐ (API 3000) Plasma heparin LC‐MS/MS Human Sodium 48 1‐(2‐Pyrimidyl)Piperazine 0.15 to 40 ng / mL ‐ (API 3000) Plasma heparin LC‐MS/MS Human Sodium 6‐Hydroxybuspirone 0.625 to 160 ng / mL ‐ (API 3000) Plasma heparin C Human Sodium Carbamazepine HPLC‐UV 48 to 25000 ng / mL 400 mg Plasma heparin 49 Carbamazepine‐10,11‐ Human Sodium HPLC‐UV 10 to 5000 ng / mL ‐ epoxide Plasma heparin LC‐MS/MS Human 1 to 128 ng / mL K EDTA 40 mg (Thermo) Plasma 2 50 LC‐MS/MS Human O‐Desmethylcarvedilol 0.2 to 25 ng / mL K EDTA ‐ (Thermo) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human 4'‐Hydroxyphenyl carvedilol 0.2 to 25 ng / mL K EDTA ‐ (Thermo) Plasma 2 50 LC‐MS/MS Human 5'‐Hydroxyphenyl carvedilol 0.2 to 25 ng / mL K EDTA ‐ (Thermo) Plasma 2 Human Lithium 51 Cefaclor HPLC‐UV 0.2 to 25 µg / mL 500 mg Plasma heparin Human Sodium 52 Cefixime HPLC‐UV 0.1 to 13 µg / mL 400 mg Plasma heparin Human 53 Cefuroxime HPLC‐UV 0.2 to 27 µg / mL K EDTA 500 mg Plasma 2 LC‐MS/MS Human 54 Cefuroxime 100 to 20135 ng / mL K EDTA 500 mg (Thermo) Plasma 2 HPLC Human Sodium 55 Celecoxib 20 to 2560 ng / mL 200 mg ‐ Flurosence Plasma heparin LC‐MS/MS Human 56 Celecoxib 20 to 2560 ng / mL K EDTA 200 mg (API 3000) Plasma 2 Human 57 Cephalexin HPLC‐UV 0.2 to 25 µg / mL K EDTA ‐ Plasma 3 LC‐MS/MS Human 58 2 to 512 ng / mL K EDTA 10 mg (API 3000) Plasma 2 LC‐MS/MS Human Cetirizine 1 to 250 ng / mL K EDTA 5 mg (Waters QPXE) Plasma 2 59 LC‐MS/MS Human 5 to 1500 ng / mL K EDTA 120 mg (Waters QPXE) Plasma 2 LC‐MS/MS Human 60 Chlorpheniramine 0.1 to 51 ng / mL K EDTA 8 mg / 5 mL (API 3000) Plasma 2 LC‐MS/MS Human 61 Chlorthalidone 2 to 1000 ng/mL K EDTA 50 mg (Thermo) Plasma 2 LC‐MS/MS Human 62 Chlorzoxazone 0.1 to 50 µg/mL K EDTA 750mg (Thermo) Plasma 2 LC‐MS/MS Human Cilazapril 1 to 256 ng / mL K EDTA 1 mg (API 3000) Plasma 3 63 LC‐MS/MS Human Cilazaprilat 0.25 to 64 ng / mL K EDTA 1 mg (API 3000) Plasma 3 LC‐MS/MS Human Cilazapril 4 to 1024 ng / mL K EDTA 2.5 mg (API 3000) Plasma 3 64 LC‐MS/MS Human Cilazaprilat 1 to 256 ng / mL K EDTA 2.5 mg (API 3000) Plasma 3 HPLC Human 65 Ciprofloxacin 25 to 6400 ng / mL K EDTA ‐ ‐ Flurosence Plasma 3 HPLC Human 66 Ciprofloxacin 20 to 2561 ng / mL K EDTA ‐ ‐ Flurosence Plasma 3 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

Human Not Ciprofloxacin HPLC‐UV 1.5 to 15 µg / mL ‐ Urine applicable Human Not Desethyleneciprofloxacin HPLC‐UV 0.5 to 5 µg / mL ‐ Urine applicable 67 Human Not Sulfociprofloxacin HPLC‐UV 0.5 to 5 µg / mL ‐ Urine applicable Human Not Oxociprofloxacin HPLC‐UV 0.5 to 5 µg / mL ‐ Urine applicable Human Not 67 Formylciprofloxacin HPLC‐UV 0.5 to 5 µg / mL ‐ Urine applicable HPLC Human 68 0.25 to 32 ng / mL Heparin ‐ ‐ Flurosence Plasma HPLC Human Sodium 69 Citalopram 0.25 to 64 ng / mL ‐ ‐ Flurosence Plasma heparin LC‐MS/MS Human Sodium Citalopram 0.25 to 32 ng / mL 20 mg (API 3000) Plasma heparin LC‐MS/MS Human Sodium 70 Demethylcitalopram 0.05 to 6 ng / mL ‐ (API 3000) Plasma heparin LC‐MS/MS Human Sodium Didemethylcitalopram 0.05 to 6 ng / mL ‐ (API 3000) Plasma heparin LC‐MS/MS Human Sodium Citalopram 0.25 to 64 ng / mL 40 mg (API 3000) Plasma heparin LC‐MS/MS Human Sodium 71 Demethylcitalopram 0.05 to 12 ng / mL ‐ (API 3000) Plasma heparin LC‐MS/MS Human Sodium Didemethylcitalopram 0.05 to 13 ng / mL ‐ (API 3000) Plasma heparin LC‐MS/MS Human Sodium S‐Citalopram 0.25 to 64 ng / mL 40 mg (API 3000) Plasma heparin 72 LC‐MS/MS Human Sodium S‐Demethylcitalopram 0.05 to 13 ng / mL ‐ (API 3000) Plasma heparin LC‐MS/MS Human Sodium Citalopram 0.251 to 128 ng / mL 40 mg (Thermo) Plasma heparin

LC‐MS/MS Human Sodium 73 Demethylcitalopram 0.126 to 64 ng / mL ‐ (Thermo) Plasma heparin

LC‐MS/MS Human Sodium Didemethylcitalopram 0.025 to 13 ng / mL ‐ (Thermo) Plasma heparin

LC‐MS/MS Human Sodium 74 Citalopram Chiral (R and S) 0.25 to 64 ng / mL 40 mg (API 3000) Plasma heparin NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human Sodium Demethylcitalopram (R and S) 0.2 to 51 ng / mL ‐ (API 3000) Plasma heparin 74 LC‐MS/MS Human Sodium Didemethylcitalopram (S) 0.2 to 51 ng / mL ‐ (API 3000) Plasma heparin

LC‐MS/MS Human Sodium 75 Clarithromycin 20 to 5120 ng / mL ‐ (API 300 or 3000) Plasma heparin

LC‐MS/MS Human Sodium 76 Clavulanic Acid 25 to 1600 ng / mL 125 mg (API 300 or 3000) Plasma heparin

LC‐MS/MS Human Clobazam 5 to 600 ng/mL K EDTA 20mg (Thermo) Plasma 2 77 LC‐MS/MS Human N‐Desmethyl Clobazam 5 to 500 ng/mL K EDTA 20mg (Thermo) Plasma 2

LC‐MS/MS Human 78 Clobazam 1 to 400 ng / mL K EDTA 2 mg / mL (Waters QPXE) Plasma 2

LC‐MS/MS Human Sodium 79 Clonazepam 0.1 to 51 ng / mL ‐ (API 300 or 3000) Plasma heparin

LC‐MS/MS Human 80 0.03 to 2 ng / mL K EDTA 0.3 mg (Thermo) Plasma 2

LC‐MS/MS Human Sodium 81 Clopidogrel 0.05 to 51 ng / mL 300 mg (Thermo) Plasma heparin

LC‐MS/MS Human 300 mg of 82 Clopidogrel Carboxylic Acid 0.049 to 25 µg / mL K EDTA (Thermo) Plasma 2 Clopidogrel

LC‐MS/MS Human 300 mg of 83 Clopidgorel Thiol 0.1 to 100 ng / mL K EDTA (Thermo) Plasma 2 Clopidogrel

LC‐MS/MS Human 84 0.7 to 400 ng / mL K EDTA 30 mg (Thermo) Plasma 2

LC‐MS/MS Human 2% Ointment(50 85 Crisaborole 0.05 to 100 ng/ mL K EDTA (Thermo) Plasma 2 mg & 100 mg)

LC‐MS/MS Human Lithium 86 0.3 to 25 ng / mL ‐ (API 3000) Plasma heparin

LC‐MS/MS Human Lithium 86 Ethinyl Estradiol 15 to 1280 pg / mL ‐ (API 3000) Plasma heparin NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No. D LC‐MS/MS Human 87 Darunavir 10 to 6400 ng / mL K EDTA 600 mg (API 3000) Plasma 2 LC‐MS/MS Human 88 Dexamethasone 0.2 to 60 ng / mL K EDTA 0.5 mg (Thermo) Plasma 2 LC‐MS/MS 89 Human plasma 0.2 to 40 ng/mL NaF & KOx 40 mg (Thermo) LC‐MS/MS Human 90 Dextroamphetamine 0.2 to 51 ng / mL K EDTA 30 mg (API 3000) Plasma 2 LC‐MS/MS Human 91 Dextromethrophan 0.1 to 100 ng/mL K EDTA 60 mg (Thermo) Plasma 2 LC‐MS/MS Human 91 Detrorphan 0.1 to 50 ng/mL K EDTA NA (Thermo) Plasma 2 LC‐MS/MS Human Sodium 0.1 to 51 ng / mL 30 mg (API 3000) Plasma heparin LC‐MS/MS Human Sodium 92 1 to 512 ng / mL ‐ (API 3000) Plasma heparin LC‐MS/MS Human Sodium Pseudoephedrine 1 to 512 ng / mL ‐ (API 3000) Plasma heparin LC‐MS/MS Human Dextromethorphan 0.05 to 12 ng / mL K EDTA 10mg (Thermo) Plasma 2 LC‐MS/MS Human 93 Pseudoephedrine 1 to 300 ng / mL K EDTA 30mg (Thermo) Plasma 2 LC‐MS/MS Human 0.05 to 12 ng / mL K EDTA 2mg (Thermo) Plasma 2 LC‐MS/MS Human 94 Diclofenac 0.05 to 25 ng / mL K EDTA 1 % gel (Thermo) Plasma 2

LC‐MS/MS Human Sodium 95 Didanosine 10 to 1280 ng / mL ‐ (API 3000) Plasma heparin

LC‐MS/MS Human 96 Dienogest 3 to 120 ng / mL K EDTA 2 mg (Thermo) Plasma 2

Human Diltiazem HPLC‐UV 3 to 385 ng / mL K EDTA ‐ Plasma 3

Human 97 Desacetyldiltiazem HPLC‐UV 1 to 128 ng / mL K EDTA ‐ Plasma 3

Human N‐Desmethyldiltiazem HPLC‐UV 3 to 385 ng / mL K EDTA ‐ Plasma 3

Human 98 Diltiazem HPLC‐UV 3 to 770 ng / mL K EDTA ‐ Plasma 3 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

Human Desacetyldiltiazem HPLC‐UV 1 to 255 ng / mL K EDTA ‐ Plasma 3 98 Human N‐Desmethyldiltiazem HPLC‐UV 3 to 780 ng / mL K EDTA ‐ Plasma 3

LC‐MS/MS Human Diltiazem 1 to 256 ng / mL K EDTA ‐ (API 3000) Plasma 3

LC‐MS/MS Human 99 Desacetyldiltiazem 0.125 to 32 ng / mL K EDTA ‐ (API 3000) Plasma 3

LC‐MS/MS Human N‐Desmethyldiltiazem 0.25 to 64 ng / mL K EDTA ‐ (API 3000) Plasma 3

LC‐MS/MS Human Diltiazem 0.8 to 800 ng / mL K EDTA ‐ (Thermo) Plasma 2

LC‐MS/MS Human 100 Desacetyldiltiazem 0.2 to 200 ng / mL K EDTA ‐ (Thermo) Plasma 2

LC‐MS/MS Human N‐Desmethyldiltiazem 0.4 to 400 ng / mL K EDTA ‐ (Thermo) Plasma 2

LC‐MS/MS Human Diltiazem 2.5 to 750 ng / mL K EDTA 420 mg (Thermo) Plasma 2

LC‐MS/MS Human 101 Desacetyldiltiazem 0.2 to 75 ng / mL K EDTA ‐ (Thermo) Plasma 2

LC‐MS/MS Human N‐Desmethyldiltiazem 2 to 150 ng / mL K EDTA ‐ (Thermo) Plasma 2

LC‐MS/MS Human Sodium 102 0.5 to 128 ng / mL 25 to 38 mg (API 3000) Plasma heparin

LC‐MS/MS Human 103 Donepezil 0.25 to 64 ng / mL K EDTA 10 mg (Thermo) Plasma 2

HPLC Human 104 0.5 to 128 ng / mL Heparin ‐ ‐ Flurosence Plasma

LC‐MS/MS Human Doxepine 0.1 to 100 ng/mL K EDTA 100 mg (Thermo) Plasma 2 105 LC‐MS/MS Human Nordoxepine 0.101 to 50.476 ng/mL K EDTA ‐ (Thermo) Plasma 2

Human 106 Doxycycline HPLC‐UV 80 to 5120 ng / mL Heparin ‐ Plasma

LC‐MS/MS Human 107 0.5 to 128 ng / mL K EDTA 60 mg (API 3000) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human 108 Duloxetine 0.5 to 128 ng / mL K EDTA 60 mg (Thermo) Plasma 2

LC‐MS/MS Human Sodium 109 Duloxetine 0.5 to 400 ng/mL 120 mg (Thermo) Plasma heparin

LC‐MS/MS Human 110 Dutasteride 60 to 5120 pg / mL K EDTA 0.5 mg (Thermo) Plasma 2 E

LC‐MS Human Sodium 111 0.02 to 5 µg / mL ‐ (API 150) Plasma heparin

LC‐MS/MS Human 112 Eliglustat 0.1 to 50 ng/mL K EDTA 84mg (Thermo) Plasma 2

LC‐MS/MS Human Enalapril 0.25 to 80 ng / mL Heparin ‐ (API 3000) Plasma

LC‐MS/MS Human 113 Enalaprilat 0.25 to 80 ng / mL Heparin ‐ (API 3000) Plasma

LC‐MS/MS Human Hydrochlorthiazide 2.5 to 800 ng / mL Heparin ‐ (API 3000) Plasma

LC‐MS/MS Human Enalapril 0.25 to 256 ng / mL K EDTA ‐ (API 3000) Plasma 2 114 LC‐MS/MS Human Enalaprilat 0.25 to 256 ng / mL K EDTA ‐ (API 3000) Plasma 2

LC‐MS/MS Mice plasma 115 Endoxifen 0.1 to 100 ng/mL K EDTA 0.2 mg/mL (Thermo) Extract 2

LC‐MS/MS Beagle Dog 116 Enrofloxacin 10 to 5000 ng/mL K EDTA 150 mg (Thermo) plasma 2

LC‐MS/MS Human 117 Eprosartan 5 to 3840 ng / mL K EDTA ‐ (Thermo) Plasma 2

LC‐MS/MS Human 118 Esomeprazole 1 to 2000 ng / mL K EDTA 20 mg (Thermo) Plasma 2

LC‐MS/MS Human 119 17 β‐Estradiol 1 to 100 pg/mL K EDTA 0.1 % Gel (API 6500) Plasma 2

Human 120 Etodolac HPLC‐UV 0.25 to 32 µg / mL Heparin ‐ Plasma NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human 121 Ethinyl Estradiol 3 to 128 pg / mL K EDTA 0.03 mg (Thermo) Plasma 2

LC‐MS/MS Human 122 Ethinyl Estradiol 0.5 to 125 pg / mL K EDTA 20 mcg (API 6500) Plasma 2

LC‐MS/MS Human 123 Exemestane 0.2 to 25 ng / mL K EDTA 25 mg (API 3000) Plasma 2

LC‐MS/MS Human 124 Exemestane 0.05 to 25 ng / mL K EDTA 25 mg (Thermo) Plasma 2

LC‐MS/MS Human Sodium Ezetimibe 0.05 to 15 ng/mL 10 mg (API 6500) Plasma heparin 125 Ezetimibe Phenoxy LC‐MS/MS Human Sodium 0.5 to 300 ng/mL 10 mg Glucuronide (API 6500) Plasma heparin F Human 126 HPLC‐UV 5 to 640 ng / mL Heparin ‐ Plasma

LC‐MS/MS Human 127 Felodipine 0.05 to 13 ng / mL K EDTA 10 mg (Thermo) Plasma 2

LC‐MS/MS Human 128 Fenofibric acid 50 to 19200 ng / mL K EDTA 135 mg (API 3000) Plasma 2

Human K EDTA/Sodium 129 Fenofibric acid HPLC‐UV 50 to 12800 ng / mL 2 ‐ Plasma heparin

Human Sodium 130 Fenofibric acid HPLC‐UV 10 to 5120 ng / mL ‐ Plasma heparin

LC‐MS/MS Human 131 Fenofibric acid 0.05 to 25 µg / mL K EDTA 215 mg (Thermo) Plasma 2

LC‐MS/MS Human Sodium 132 0.02 to 20 ng / mL ‐ (API 3000) Plasma heparin

Human plasma LC‐MS/MS Fesoterodine (Bufferized) 0.45 to 100 pg/mL K EDTA 3.1 mg (API 6500) 2 133 Human plasma LC‐MS/MS 5‐Hydroxy Tolterodine (Bufferized) 30 to 11000 pg/mL K EDTA 6.2 mg (API 6500) 2

HPLC Human Sodium 134 5 to 640 ng / mL ‐ ‐ Flurosence Plasma heparin NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human 135 Fexofenadine 1 to 1000 ng / mL K EDTA 180 mg (Waters QPXE) Plasma 2

LC‐MS/MS Human 136 Fexofenadine 3 to 3500 ng/mL K EDTA 180mg (Thermo) Plasma 2

LC‐MS/MS Human 137 Fingolimod 25 to 500 pg / mL K EDTA 3 X 0.5 mg (Thermo) Blood 2

LC‐MS/MS Human 3 X 0.5 mg of 138 Fingolimod Phosphate 75 to 4000 pg / mL K EDTA (Waters QPXE) Blood 2 fingolimod

Human Sodium 139 Fluconazole HPLC‐UV 0.1 to 13 µg / mL 150 mg Plasma heparin

LC‐MS Human 140 0.15 to 37.5 ng / mL Heparin 20 mg (API 150) Plasma

LC‐MS Human 140 Norfluoxetine 0.15 to 37.5 ng / mL Heparin ‐ (API 150) Plasma

LC‐MS Human Sodium Fluoxetine 0.5 to 64 ng / mL ‐ (API 150) Plasma heparin 141 LC‐MS Human Sodium Norfluoxetine 0.5 to 64 ng / mL ‐ (API 150) Plasma heparin

LC‐MS/MS Human 142 Flupenthixol 0.1 to 13 ng / mL K EDTA 10 mg (API 3000) Plasma 2

Fluticasone LC‐MS/MS Human 143 1 to 32 pg / mL K EDTA ‐ Propionate (Thermo) Plasma 2

Fluticasone LC‐MS/MS Human 144 5 to 640 pg / mL K EDTA ‐ Propionate (Thermo) Plasma 2

LC‐MS/MS Human 145 Fluvastatin 2 to 512 ng / mL K EDTA ‐ (Thermo) Plasma 2

LC‐MS/MS Human Sodium 146 0.5 to 64 ng / mL ‐ (API 3000) Plasma heparin

LC‐MS/MS Dog Sodium 147 Fulvestrant 0.5 to 40 ng / mL 50 mg (Thermo) Plasma heparin

LC‐MS/MS Human 148 Fulvestrant 0.05 to 40 ng / mL K EDTA 50 mg (Thermo) Plasma 2 G NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human 149 Gabapentin 75 to 9600 ng / mL K EDTA 600 mg (API 3000) Plasma 2

LC‐MS/MS Human 150 Galantamine 0.5 to 63 ng / mL K EDTA 8 mg (API 3000) Plasma 2

HPLC Human 151 Ganciclovir 30 to 1920 ng / mL K EDTA ‐ ‐ Flurosence Plasma 3

HPLC Human 152 Gatifloxacin 25 to 6400 ng / mL K EDTA ‐ ‐ Flurosence Plasma 3

LC‐MS/MS Human 153 Glimepiride 2 to 1024 ng / mL K EDTA 4 mg (API 300 or 3000) Plasma 3

Human 154 Glipizide HPLC‐UV 10 to 640 ng / mL K EDTA ‐ Plasma 2

LC‐MS Human 155 Glipizide 10 to 640 ng / mL K EDTA ‐ (API 150) Plasma 2

LC‐MS/MS Human 156 Glipizide 10 to 1280 ng / mL K EDTA ‐ (API 300 or 3000) Plasma 2

LC‐MS/MS Human 157 Glipizide 2.5 to 640 ng / mL K EDTA 10 mg (API 3000) Plasma 2 LC‐MS Human 158 Glyburide 2 to 128 ng / mL K EDTA ‐ (API 150) Plasma 3 LC‐MS/MS 159 Glycopyrrolate Human plasma 1 to 400 pg/mL K EDTA 44 µg (Thermo) 2

LC‐MS/MS Human 160 Griseofulvin 15 to 3840 ng / mL K EDTA ‐ (API 300 or 3000) Plasma 3

LC‐MS/MS Human 161 0.02 to 10 ng / mL K EDTA ‐ (Thermo) Plasma 2

LC‐MS/MS Human 162 Guaifenesin 10 to 1280 ng / mL K EDTA ‐ (Thermo) Plasma 2

LC‐MS/MS Human 163 Guaifenesin 10 to 5000 ng/mL K EDTA 1200 mg (Thermo) Plasma 2 H NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human 7.5 mg / 164 0.4 to 51 ng / mL K EDTA (Thermo) Plasma 2 5 mL

LC‐MS/MS Human Sodium Hydrocodone 1 to 128 ng / mL ‐ (API 3000) Plasma heparin

LC‐MS/MS Human Sodium 165 1 to 128 ng / mL ‐ (API 3000) Plasma heparin

LC‐MS/MS Human 100 to Sodium Ibuprofen ‐ (API 3000) Plasma 12800 ng / mL heparin

LC‐MS/MS Human Hydralazine 0.25 to 128 ng/mL K EDTA 50 mg (Thermo) Plasma 2 166 hydralazine pyruvic acid LC‐MS/MS Human 1.2 to 1250 ng/mL K EDTA ‐ hydrazone (HPH) (Thermo) Plasma 2

LC‐MS Human 167 Hydrochlorthiazide 5 to 1280 ng / mL K EDTA 12.5 mg to 25 mg (API 150) Plasma 2

LC‐MS/MS Human 168 Hydromorphone 50 to 15000 pg / mL K EDTA 32 mg (Thermo) Plasma 2

LC‐MS/MS Human 169 Hydromorphone 0.05 to 6 ng / mL K EDTA 16 mg (Thermo) Plasma 2 I

Human Sodium 170 Ibuprofen HPLC‐UV 0.4 to 512 µg / mL 200 mg Plasma heparin

LC‐MS/MS Human 171 Ibuprofen 0.1 to 40 µg/mL Sodium Heparin 200mg (API 6500) Plasma

LC‐MS/MS Human 172 Ibuprofen 0.2 to 50 µg / mL K EDTA 600 mg (Waters QPXE) Plasma 2

LC‐MS/MS Human Ibuprofen 0.2 to 51 µg/mL K EDTA 200 mg (Thermo) Plasma 2 173 LC‐MS/MS Human Methocarbamol 0.06 to 15 µg/mL K EDTA 500 mg (Thermo) Plasma 2

LC‐MS/MS Human 174 Imatinib 5 to 3500 ng / mL K EDTA 400 mg (Thermo) Plasma 2

Human 175 Indapamide HPLC‐UV Whole 10 to 1280 ng / mL Heparin ‐ Blood NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human Itraconazole 1 to 320 ng / mL Heparin ‐ (API 300 or 3000) Plasma 176 LC‐MS/MS Human Hydroxy Itraconazole 1 to 320 ng / mL Heparin ‐ (API 300or 3000) Plasma LC‐MS/MS Human Itraconazole 2 to 512 ng / mL K EDTA 100 mg (API 3000) Plasma 2 177 LC‐MS/MS Human Hydroxy Itraconazole 2 to 512 ng / mL K EDTA ‐ (API 3000) Plasma 2 LC‐MS/MS Human Ivabradine 20 to 20000 ng / mL K EDTA 15mg (Waters QPXE) Plasma 2 178 N‐desmethyl LC‐MS/MS Human 15 mg of 20 to 2480 ng / mL K EDTA Ivabradine (Waters QPXE) Plasma 2 Ivabradine LC‐MS/MS 179 Ivermectin Human plasma 0.25 to 50 ng/mL K EDTA 3 mg (API 6500) 2 L LC‐MS/MS Human 180 5 to 1500 ng/mL K EDTA 200 mg (Thermo) Plasma 2 LC‐MS/MS Human Sodium 181 Lamotrigine 10 to 1280 ng / mL 50 mg (Thermo) Plasma heparin

LC‐MS/MS Human Sodium 182 Lansoprazole 2 to 4096 ng / mL 30 mg (API 300 or 3000) Plasma heparin

LC‐MS/MS Human 183 Leuprolide 0.025 to 13 ng / mL K EDTA ‐ (Thermo) Plasma 2

LC‐MS/MS Human 184 Letrozole 0.5 to 128 ng / mL K EDTA 2.5 mg (API 3000) Plasma 2

LC‐MS Human 185 Levetiracetam 0.5 to 24 µg / mL K EDTA ‐ (API 150) Plasma 3

LC‐MS/MS Human 186 Levetiracetam 0.375 to 48 µg / mL K EDTA 1 gm (API 3000) Plasma 2

LC‐MS/MS 187 Human plasma 20 to 10000 pg/mL K EDTA 2 mg (Thermo) 2

LC‐MS/MS Human Lithium 188 Lisinopril 0.25 to 64 ng / mL ‐ (API 300 or 3000) Plasma heparin

LC‐MS/MS Human 189 Lisinopril 0.25 to 128 ng / mL Heparin ‐ (API 300 or 3000) Plasma NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human Lithium 190 Lisinopril 1 to 256 ng / mL ‐ (API 300 or 3000) Plasma heparin

LC‐MS/MS Human 191 0.05 to 6 ng / mL K EDTA 2 mg (Thermo) Plasma 2

LC‐MS/MS Human 0.1 to 51 ng / mL Heparin ‐ (API 3000) Plasma

LC‐MS/MS Human 192 Descarboethoxyloratadine 0.1 to 51 ng / mL Heparin ‐ (API 3000) Plasma

LC‐MS/MS Human Pseudoephedrine 2.5 to 1280 ng / mL Heparin ‐ (API 3000) Plasma

LC‐MS/MS Human Loratadine 0.1 to 51 ng / mL Heparin ‐ (API 300 or 3000) Plasma 193 LC‐MS/MS Human Descarboethoxyloratadine 0.1 to 25 ng / mL Heparin ‐ (API 300 or 3000) Plasma

Human 194 Loratadine LC‐MS/MS (API 6500) 5 to 5000 pg / mL K EDTA 5mg Plasma 2

LC‐MS/MS Human Descarboethoxyloratadine 10 to 10000 pg / mL K EDTA ‐ (API 6500) Plasma 2 194 LC‐MS/MS Human Pseudoephedrine 2.5 to 1250 ng / mL K EDTA 120 mg (API 6500) Plasma 2

LC‐MS/MS Human Loratadine 40 to 12000 pg/mL K EDTA 10 mg (API 6500) Plasma 2

LC‐MS/MS Human 195 40 to 12000 pg/mL K EDTA N/AP (API 6500) Plasma 2

LC‐MS/MS Human Pseudoephedrine 5 to 1600 ng/mL K EDTA 240 mg (API 6500) Plasma 2

LC‐MS/MS Human 196 Lormetazepam 0.06 to 8 ng / mL K EDTA ‐ (Thermo) Plasma 2

LC‐MS/MS Human Losartan 4 to 1027 ng / mL K EDTA 100 mg (API 3000) Plasma 2 197 LC‐MS/MS Human Losartan Hydroxy Acid 4 to 1024 ng / mL K EDTA ‐ (API 3000) Plasma 2

LC‐MS/MS Human 198 Lovastatin 0.1 to 25 ng / mL Heparin ‐ (API 300 or 3000) Plasma NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human 198 Lovastatin Hydroxy Acid 0.2 to 51 ng / mL Heparin ‐ (API 300 or 3000) Plasma M LC‐MS/MS Human 199 1.01 to 256 ng / mL K EDTA 25 mg (API 3000) Plasma 2 Human 200 Mefanamic Acid HPLC‐UV 50 to 6400 ng / mL K EDTA ‐ Plasma 2 LC‐MS/MS Human 201 Mefanamic Acid 50 to 12800 ng / mL K EDTA 250 mg (API 3000) Plasma 2 Medroxyprogesterone LC‐MS/MS Human Sodium 202 0.02 to 10 ng / mL ‐ Acetate (API 3000) Plasma heparin Medroxyprogesterone LC‐MS/MS Human Sodium 203 50 to 10000 pg/mL 150 mg Acetate (Thermo) Plasma heparin LC‐MS/MS Human 204 Megestrol Acetate 0.3 to 153.6 ng/mL K EDTA 40 mg / mL (Thermo) Plasma 2 Human Plasma or 205 Meloxicam HPLC‐UV 0.03 to 1.92 µg / mL K EDTA ‐ Dog 2 Plasma LC‐MS/MS Human Not 206 Meloxicam 1 to 128 ng / mL ‐ (API 3000) Urine applicable LC‐MS/MS Human 207 Meloxicam 10 to 2560 ng / mL K EDTA 15 mg (API 3000) Plasma 2 LC‐MS/MS Human 208 Mesalamine 5 to 3000 ng/mL K EDTA 500 mg (API 6500) Plasma 2 Human 209 Metaxalone HPLC‐UV 1 to 256 µg / mL Heparin ‐ Plasma Human 210 Metaxalone HPLC‐UV 1 to 256 µg / mL K EDTA ‐ Plasma 3 Human 211 Metaxalone LC‐MS (API 150) 5 to 2560 ng / mL K EDTA ‐ Plasma 3 LC‐MS/MS Human 212 Metaxalone 20 to 6000 ng / mL K EDTA 400 mg (API 6500) Plasma 2 LC‐MS/MS Human 213 0.1 to 50 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Human Sodium Fluoride & 214 Methylphenidate 0.1 to 50 ng/mL 54mg (Thermo) Plasma Potassium Oxalate NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human 215 Methylphenidate 0.026 to 15 ng/mL K EDTA 20 mg (Thermo) Plasma 2 L‐Threo‐ Human LC‐MS/MS (API 6500) 1 to 195 pg/mL K EDTA 18 mg Methylphenidate Plasma 2 216 D‐Threo‐ Human LC‐MS/MS (API 6500) 25 to 9800 pg/mL K EDTA NA Methylphenidate Plasma 2 LC‐MS/MS Human 217 Methylphenidate Achiral 0.1 to 50 ng/mL K EDTA 54 mg (Thermo) Plasma 2 Methylphenidate LC‐MS/MS Human 100 to 30000 K EDTA 54 mg Chiral(L&D) (API 6500) Plasma pg/mL(D) 2 218 Methylphenidate LC‐MS/MS Human 50 to 4000 pg/mL(L) K EDTA 54 mg Chiral(L&D) (API 6500) Plasma 2

Methylphenidate LC‐MS/MS Human Sodium fluoride & 15 to 3000 pg/mL (L) 60 mg Chiral(L&D) (Thermo) Plasma Potassium oxalate 219 Methylphenidate LC‐MS/MS Human 200 to 40000 pg/mL Sodium fluoride & 60 mg Chiral(L&D) (Thermo) Plasma (D) Potassium oxalate

LC‐MS/MS Human Sodium fluoride 220 Methylprednisolone 0.4 to 51 ng / mL ‐ (API 3000) Plasma potassium oxalate

80mg/mL LC‐MS/MS Human Sodium Fluoride & 221 Methylprednisolone 0.4 to 75 ng/mL Injectable (API 6500) Plasma Potassium Oxalate suspension LC‐MS/MS Human Sodium 222 1 to 512 ng / mL 200 mg (API 3000) Plasma heparin

LC‐MS/MS Human 10.01 to 223 Metformin K EDTA 1000 mg (API 3000) Plasma 2002 ng / mL 2

LC‐MS Human Not 224 Metformin 2 to 256 µg / mL 1000 mg (API 150) Urine applicable

LC‐MS/MS Human 225 Methazolamide 5 to 10000 ng / mL K EDTA 150 mg (Waters QPXE) Plasma 2 Human LC‐MS/MS 226 Methazolamide Whole 100 to 50000 ng / mL K EDTA 150 mg (Waters QPXE) 2 Blood LC‐MS/MS Human 227 Methazolamide 5 to 9800 ng/mL K EDTA 150 mg (Thermo) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human 5mg/0.1 mL Nasal Midazolam 1 to 200 ng/mL K EDTA (Thermo) Plasma 2 Spray 228 LC‐MS/MS Human α‐Hydroxy Midazolam 0.1 to 20 ng/mL K EDTA ‐ (Thermo) Plasma 2

LC‐MS/MS Human 229 Minocycline 4 to 3500 ng / mL K EDTA 45 mg to 135 mg (Thermo) Plasma 2

LC‐MS/MS Human Sodium 230 0.5 to 128 ng / mL ‐ (API 300 or 3000) Plasma heparin

LC‐MS/MS Human Lithium Misoprostol Acid 10 to 1280 pg / mL ‐ (Thermo) Plasma heparin 231 LC‐MS/MS Human Lithium Diclofenac 20 to 2560 ng / mL ‐ (Thermo) Plasma heparin

LC‐MS/MS Human 232 Mometasone furoate 0.5 to 100 pg/mL K EDTA 50 µg Nasal spray (Thermo) Plasma 2

LC‐MS/MS Human 233 Monomethyl fumarate 10 to 6000 ng/mL K EDTA 120 mg (API 6500) Plasma 2

LC‐MS/MS Human Monomethyl fumarate 20 to 5000 ng / mL K EDTA 240 mg DMF (Thermo) Plasma 2 234 LC‐MS/MS Human Monoethyl fumarate 20 to 5000 ng / mL K EDTA (Thermo) Plasma 2

Human 235 Mycophenolic Acid HPLC‐UV 0.1 to 51 µg / mL K EDTA ‐ Plasma 2

LC‐MS/MS Human Mycophenolate Mofetil 0.04 to 20 ng / mL K EDTA 250 mg (Thermo) Plasma 2 236 LC‐MS/MS Human Mycophenolic Acid 0.1 to 51 µg / mL K EDTA ‐ (Thermo) Plasma 2

6‐Methoxy‐2‐ HPLC Human 237 0.5 to 32 µg / mL Heparin ‐ Naphthaleneacetic Acid ‐ Flurosence Plasma N LC‐MS/MS Human 2 to 256 ng / mL K EDTA ‐ (API 3000) Plasma 2 238 LC‐MS/MS Human Bendroflumethiazide 1 to 128 ng / mL K EDTA ‐ (API 3000) Plasma 2 LC‐MS/MS Human 239 1 to 500 pg/mL K EDTA 20 mg (API 6500) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS 240 Naloxone Human plasma 0.02 to 20 ng/mL K EDTA 0.4 mg/mL (Thermo) 2 LC‐MS/MS Human Naloxone‐3‐β‐D‐Glucuronide 1 to 300 ng/mL K EDTA 20 mg (API 6500) Plasma 2 241 LC‐MS/MS Human 0.5 to 150 ng/mL K EDTA 40 mg (API 6500) Plasma 2 Sodium heparin for Human or LC‐MS/MS human plasma; Dog 0.1 to 205 ng / mL 50 mg (API 3000) K EDTA for dog Plasma 3 plasma 242 Sodium heparin for Human or LC‐MS/MS human plasma; 6‐ß‐Naltrexol Dog 0.1 to 205 ng / mL ‐ (API 3000) K3EDTA for dog Plasma plasma

LC‐MS/MS Human Not Naltrexone 1 to 512 ng / mL ‐ (API 3000) Urine applicable 243 LC‐MS/MS Human 9.947 to Not 6‐ß‐Naltrexol ‐ (API 3000) Urine 5092 ng / mL applicable Human 244 Naproxen HPLC ‐ Flurosence 0.5 to 128 µg / mL Heparin ‐ Plasma LC‐MS/MS Human 245 15 to 5000 pg/mL K EDTA 5 mg (API 6500) Plasma 2 Human LC‐MS (API 150) 6.25 to 800 ng / mL Heparin ‐ Plasma 246 Human 2‐ LC‐MS (API 150) 1.88 to 240 ng / mL Heparin ‐ Plasma m‐ Human 246 LC‐MS (API 150) 1.25 to 160 ng / mL Heparin ‐ Chlorophenylpiperazine Plasma LC‐MS/MS Human Niacin 20 to 2000 ng / mL K EDTA 1000 mg (Thermo) Plasma 2 247 LC‐MS/MS Human Nicotinuric acid 20 to 2000 ng / mL K EDTA ‐ (Thermo) Plasma 2 Human 248 Nifedipine LC‐MS (API 150) 0.5 to 200 ng / mL K EDTA 60 mg Plasma 3 LC‐MS/MS Human 249 Nifedipine 0.5 to 200 ng / mL K EDTA 60 mg (API 3000) Plasma 2 LC‐MS/MS Human 250 Nintedanib 0.050‐ 20 ng/mL K EDTA 150mg (Thermo) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS 251 Nitisinone Human plasma 10 to 2500 ng/mL K EDTA 10 mg (Thermo) 2 Human Sodium 252 Nitrofurantoin HPLC‐UV 20 to 2560 ng / mL ‐ Plasma heparin LC‐MS/MS Human 25mg/5mL 253 Nitrofurantoin 5 to 1000 ng/mL K EDTA (Thermo) Plasma 2 suspension LC‐MS/MS Human Nitroglycerin 20 to 4000 pg/mL K EDTA (API 6500) Plasma 2 LC‐MS/MS Human 254 1,3‐Dinitroglycerin 40 to 4000 pg/mL K EDTA 1.5mg (API 6500) Plasma 2 LC‐MS/MS Human 1,2‐Dinitroglycerin 40 to 8000 pg/mL K EDTA (API 6500) Plasma 2 Human 255 HPLC‐UV 10 to 5120 ng / mL Heparin 300 mg Plasma Human 255 Desmethylnizatidine HPLC‐UV 5 to 2560 ng / mL Heparin ‐ Plasma Human 256 Norfloxacin HPLC ‐ Flurosence 20 to 2560 ng / mL K EDTA ‐ Plasma 3 Human 257 Nortriptyline HPLC‐UV 1 to 64 ng / mL K EDTA ‐ Plasma 3 LC‐MS/MS Human 258 Norethindrone 50 to 15000 pg / mL K EDTA 0.35 mg / 1 mg (Thermo) Plasma 2 LC‐MS/MS Human 259 RS‐Norketotifen 0.2 to 70 ng/mL K EDTA 8 mg (Thermo) Plasma 2 LC‐MS/MS Human 260 S‐Norketotifen 1 ‐ 1000 ng/mL K EDTA 4 mg/8mg/16mg (Thermo) Plasma 2 LC‐MS/MS Human 260 R‐ Norketotifen 1 ‐ 1000 ng/mL K EDTA NA (Thermo) Plasma 2 O LC‐MS/MS Human 261 0.2 to 25 ng / mL K EDTA 10 mg (API 3000) Plasma 2 LC‐MS/MS Human Olmesartan 6 to 1536 ng / mL K EDTA 40 mg (API 3000) Plasma 2 262 LC‐MS/MS Human 2.01 to Hydrochlorthiazide K EDTA 25 mg (API 3000) Plasma 512.46 ng / mL 2 LC‐MS/MS Human Sodium 263 Omeprazole 1 to 1024 ng / mL ‐ (API 3000) Plasma heparin NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human 264 Omeprazole 5 to 3450 ng / mL K EDTA 40 mg (Thermo) Plasma 2 LC‐MS/MS Human 265 Omeprazole 5 to 3400 ng/mL K EDTA 20 mg (Thermo) Plasma 2 LC‐MS/MS Human Lithium 266 0.5 to 128 ng / mL 8 mg (API 3000) Plasma heparin LC‐MS/MS Human 300 mg/ 267 Oxcarbazepine 0.01 to 10 µg / mL K EDTA (API 3000) Plasma 2 5 mL 10,11‐dihydro‐10‐ LC‐MS/MS Human 268 0.05 to 51.2 µg / mL K EDTA ‐ Hydroxycarbamazepine (API 3000) Plasma 2 LC‐MS/MS Human 300 mg/ Oxcarbazepine 0.01 to 5.12 µg / mL K EDTA (Thermo) Plasma 2 5 mL 269 10,11‐dihydro‐10‐ LC‐MS/MS Human 0.05 to 25.6 µg / mL K EDTA ‐ Hydroxycarbamazepine (Thermo) Plasma 2 LC‐MS/MS Human 270 Oxycodone 0.1 to 60 ng / mL K EDTA 5 mg (Thermo) Plasma 2 LC‐MS/MS Human 271 Oxycodone 0.5 to 150 ng / mL K EDTA 80 mg (Thermo) Plasma 2 LC‐MS/MS Human Oxycodone 0.1 to 101 ng / mL Heparin ‐ (API 3000) Plasma 272 LC‐MS/MS Human 0.1 to 100 ng / mL Heparin ‐ (API 3000) Plasma LC‐MS/MS Human Oxycodone 0.234 to 60 ng / mL K EDTA 20 mg (Thermo) Plasma 2 273 LC‐MS/MS Human Oxymorphone 0.234 to 60 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Human Oxycodone 0.5 to 255 ng / mL K EDTA ‐ (API 3000) Plasma 3 274 LC‐MS/MS Human 0.5 to 256 ng / mL K EDTA ‐ (API 3000) Plasma 3 LC‐MS/MS Human 274 Oxymorphone 0.1 to 51.2 ng / mL K EDTA ‐ (API 3000) Plasma 3 LC‐MS/MS Human Oxybutynin 0.16 to 20 ng / mL Heparin ‐ (API 300 or 3000) Plasma 275 LC‐MS/MS Human Desethyloxybutynin 0.3 to 40 ng / mL Heparin ‐ (API 300 or 3000) Plasma LC‐MS/MS Human Oxymorphone 40 to 1280 pg / mL K EDTA ‐ (Thermo) Plasma 2 276 LC‐MS/MS Human Hydroxy Oxymorphone 25 to 800 pg / mL K EDTA ‐ (Thermo) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human Oxymorphone 40 to 3200 pg / mL K EDTA 10 mg (Thermo) Plasma 2 277 LC‐MS/MS Human Hydroxy Oxymorphone 25 to 2000 pg / mL K EDTA 10 mg (Thermo) Plasma 2 LC‐MS/MS Human 0.025 to Oxymorphone K EDTA 20 mg (Thermo) Plasma 8.000 ng/mL 2 278 LC‐MS/MS Human 0.025 to Hydroxy Oxymorphone K EDTA 20 mg (Thermo) Plasma 8.000 ng/mL 2 P LC‐MS/MS Human 279 Pantoprazole 20 to 5120 ng / mL K EDTA 40 mg (API 3000) Plasma 2 Human Sodium 280 HPLC ‐ Flurosence 0.2 to 50 ng / mL ‐ Plasma heparin Human Sodium 281 Paroxetine HPLC ‐ Flurosence 1.6 to 200 ng / mL ‐ Plasma heparin Human 282 Pentoxifylline HPLC‐UV 5 to 240 ng / mL K EDTA ‐ Plasma 3 LC‐MS/MS Human 283 0.2 to 1.28 ng / mL Heparin ‐ (API 3000) Plasma LC‐MS/MS Human 50 mg/mL Oral 284 Phenobarbital 20 to 2000 ng/mL K EDTA (Thermo) Plasma 2 solution LC‐MS/MS Human 285 (Total) 4 to 512 ng / mL K EDTA 10 mg (Thermo) Plasma 2 Human 286 Phenytoin HPLC‐UV 0.04 to 2.56 µg / mL K EDTA ‐ Plasma 3 LC‐MS/MS Human 287 Phytonadione‐ Trans 0.3 to 100 ng/mL K EDTA 5 mg (API 6500) Plasma 2 LC‐MS/MS Human 287 Phytonadione‐ Cis 0.3 to 100 ng/mL K EDTA 5 mg (API 6500) Plasma 2 LC‐MS/MS Human Phytonadione‐ Trans 1 to 500 ng/mL K EDTA 5 mg (API 6500) Plasma 2 288 LC‐MS/MS Human Phytonadione‐ Cis 1 to 500 ng/mL K EDTA 5 mg (API 6500) Plasma 2

LC‐MS/MS Human Sodium fluoride and 289 Pomalidomide 0.2 to 125 ng/mL 4 mg (API 6500) Plasma Potassium oxalate NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human 290 Pramipexole 50 to 3200 pg / mL K EDTA ‐ (Thermo) Plasma 2 *Prasugrel LC‐MS/MS Human 10 mg of 291 0.2 to 150 ng / mL K EDTA (R‐138727) (Thermo) Plasma 2 Prasugrel *Prasugrel inactive metabolite LC‐MS/MS Human 10 mg of 292 0.25 to 127 ng / mL K EDTA (R‐95913) (Thermo) Plasma 2 Prasugrel LC‐MS/MS Human Sodium Pravastatin 0.25 to 128 ng / mL ‐ (API 3000) Plasma heparin 293 LC‐MS/MS Human Sodium 3‐α‐Hydroxy Pravastatin 0.25 to 128 ng / mL ‐ (API 3000) Plasma heparin LC‐MS/MS Human Sodium Pravastatin 1 to 512 ng / mL 80 mg (API 3000) Plasma heparin 294 LC‐MS/MS Human Sodium 3‐α‐Hydroxy Pravastatin 1 to 512 ng / mL ‐ (API 3000) Plasma heparin LC‐MS/MS Human Sodium Pravastatin 1 to 512 ng / mL 80 mg (Thermo) Plasma heparin 295 LC‐MS/MS Human Sodium 3‐α‐Hydroxy Pravastatin 1 to 512 ng / mL ‐ (Thermo) Plasma heparin LC‐MS/MS Human 296 Primidone 0.2 to 25 µg / mL K EDTA ‐ (API 3000) Plasma 2 LC‐MS/MS Human Phenobarbital 0.2 to 25 µg / mL K EDTA ‐ (API 3000) Plasma 2 296 LC‐MS/MS Human Phenylethylmalonamide 0.2 to 25 µg / mL K EDTA ‐ (API 3000) Plasma 2 LC‐MS/MS Human 297 Progesterone 0.04 to 40 ng/mL K EDTA 200 mg (API 6500) Plasma 2 LC‐MS/MS Human 298 Pseudoephedrine 1 to 400 ng/mL Sodium Heparin 30mg / 120 mg (API 6500) Plasma Q LC‐MS/MS Human 299 1 to 1024 ng / mL K EDTA 200 mg (Thermo) Plasma 2 LC‐MS/MS Human 300 Quetiapine 1 to 1000 ng / mL K EDTA 20 mg (Waters QPXE) Plasma 2 R LC‐MS/MS Human 301 Rabeprazole 2 to 1024 ng / mL K EDTA 20 mg (API 3000) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human Ramipril 0.05 to 6 ng / mL K EDTA 2.5 mg (API 3000) Plasma 3 302 LC‐MS/MS Human Ramiprilat 0.05 to 6 ng / mL K EDTA ‐ (API 3000) Plasma 3 LC‐MS/MS Human Ramipril 0.05 to 6 ng / mL K EDTA 2.5 mg (Thermo) Plasma 2 303 LC‐MS/MS Human Ramiprilat 0.05 to 6 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Human Ramipril 0.05 to 51 ng / mL K EDTA 10 mg (API 3000) Plasma 3 304 LC‐MS/MS Human Ramiprilat 0.05 to 51 ng / mL K EDTA ‐ (API 3000) Plasma 3 LC‐MS/MS Human Ramipril 0.05 to 51 ng / mL K EDTA 10 mg (Thermo) Plasma 2 305 LC‐MS/MS Human Ramiprilat 0.05 to 51 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Human 306 15 to 1920 ng / mL K EDTA 300 mg (Thermo) Plasma 2 Human Rifabutin LC‐MS (API 150) 10 to 1280 ng / mL K EDTA ‐ Plasma 2 Human 307 25‐O‐Desacetylrifabutin LC‐MS (API 150) 2.5 to 320 ng / mL K EDTA ‐ Plasma 2 Human Clofazimine LC‐MS (API 150) 5 to 640 ng / mL K EDTA ‐ Plasma 2 LC‐MS/MS Human 308 Risedronate 0.2 to 25 ng / mL K EDTA 35 mg (Thermo) Plasma 2 LC‐MS/MS Human 309 Risedronate 0.2 to 128 ng / mL K EDTA 75 mg (Thermo) Plasma 2 LC‐MS/MS Human Transdermal 310 Rivastigmine 0.3 to 63 ng / mL K EDTA (Thermo) Plasma 2 Patch 9.5 mg LC‐MS/MS Human 311 Rivastigmine 0.3 to 63 ng / mL K EDTA 9.5 mg (API 6500) Plasma 2 LC‐MS/MS Human Sodium 312 Rosiglitazone 2 to 1024 ng / mL 8 mg (API 3000) Plasma heparin LC‐MS/MS Human 313 Rosuvastatin 0.1 to 25 ng / mL K EDTA 20 mg (Thermo) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human 314 Rosuvastatin 0.5 to 100 ng / mL K EDTA 40 mg (Thermo) Plasma 2 S LC‐MS/MS Human 315 Scopolamine 1 to 400 pg/mL K EDTA 1 mg Patch (API 6500) Plasma 2 LC‐MS/MS Human Sodium 0.25 to 250 ng / mL 100 mg (API 3000) Plasma heparin 316 LC‐MS/MS Human Sodium N‐ 0.25 to 250 ng / mL ‐ (API 3000) Plasma heparin LC‐MS/MS Human Sildenafil 1 to 500 ng/mL K EDTA 10 mg/mL (API 6500) Plasma 2 317 LC‐MS/MS Human N‐Desmethyl Sildenafil 0.5 to 75 ng/mL K EDTA ‐ (API 6500) Plasma 2 LC‐MS/MS Human Sodium Simvastatin 0.1 to 25 ng / mL ‐ (API 300 or 3000) Plasma heparin 318 Simvastatin LC‐MS/MS Human Sodium 0.1 to 25 ng / mL ‐ Hydroxy Acid (API 300 or 3000) Plasma heparin LC‐MS/MS Human Simvastatin 0.1 to 51.2 ng / mL K EDTA 80 mg (Thermo) Plasma 2 319 Simvastatin LC‐MS/MS Human 0.1 to 25.6 ng / mL K EDTA ‐ Hydroxy Acid (Thermo) Plasma 2 Human LC‐MS/MS 320 Sirolimus Whole 0.4 to 51 ng / mL K EDTA 2 mg (API 3000) 2 Blood LC‐MS/MS Human 321 Sitagliptin 1 to 512 ng / mL K EDTA 100 mg (Thermo) Plasma 2 HPLC Human 322 10 to 2560 ng / mL heparin ‐ ‐ Flurosence Plasma Human Sulfamethoxazole HPLC‐UV 0.2 to 102 µg / mL K EDTA ‐ Plasma 3 323 Human Trimethoprim HPLC‐UV 0.02 to 2.56 µg / mL K EDTA 50 mg Plasma 3 LC‐MS/MS Human 0.01 to 1.28 ng / mL K EDTA ‐ (Thermo) Plasma 2 324 LC‐MS/MS Human Triazolam 0.1 to 12.8 ng / mL K EDTA ‐ (Thermo) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human Sufentanil 2 to 256 pg / mL K EDTA 10 mcg (Thermo) Plasma 2 325 LC‐MS/MS Human Triazolam 0.05 to 6.4 ng / mL K EDTA 200 mcg (Thermo) Plasma 2 LC‐MS Human Sulfasalazine 20 to 2560 ng / mL K EDTA ‐ (API 150) Plasma 3 LC‐MS Human Sulfapyridine 200 to 25600 ng / mL K EDTA ‐ (API 150) Plasma 3 326 LC‐MS Human 5‐Aminosalicylic Acid 20 to 2560 ng / mL K EDTA ‐ (API 150) Plasma 3 LC‐MS Human Acetyl‐5‐Aminosalicylic Acid 10 to 1280 ng / mL K EDTA ‐ (API 150) Plasma 3 LC‐MS/MS Human 327 0.1 to 40 ng/mL K EDTA 20 mg (Thermo) Plasma 2 Human LC‐MS/MS Plasma 328 Sumatriptan 0.5 to 128 ng / mL K EDTA ‐ (API 300 or 3000) or Pig 3 Plasma T Human LC‐MS/MS 329 Tacrolimus Whole 0.2 to 25 ng / mL K EDTA 0.5 to 4 mg (Thermo) 2 Blood LC‐MS/MS Human 330 Tamoxifen 0.25 to 64 ng / mL K EDTA 20 mg (API 3000) Plasma 2 LC‐MS Human Tamoxifen 0.25 to 64 ng / mL Heparin ‐ (API 150) Plasma 331 LC‐MS Human N‐Desmethyltamoxifen 0.25 to 64 ng / mL Heparin ‐ (API 150) Plasma LC‐MS/MS Human 332 0.05 to 25 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Human 333 Temazepam 4 to 1024 ng / mL K EDTA 30 mg (API 3000) Plasma 2 HPLC Human 334 0.5 to 64 ng / mL Heparin ‐ ‐ Flurosence Plasma Human 335 Terbinafine HPLC‐UV 0.01 to 2.5 µg / mL K EDTA 250 mg Plasma 3 LC‐MS/MS Human 336 Testosterone 0.1 to 25 ng / mL K EDTA 1% gel (Waters QPXE) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human 337 Testosterone 0.1 to 25 ng/mL N/AP 1.62 % Gel (Thermo) Serum LC‐MS/MS Human 0.015 to 3.84 ng / mL K EDTA 50 mg (Thermo) Plasma 2 LC‐MS/MS Human 338 α‐ 0.625 to 160 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Human β‐Dihydrotetrabenazine 0.469 to 120 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Human 339 Tetracycline 200 to 20000 ng / mL K EDTA 500 mg (Thermo) Plasma 2 Human 340 Theophylline HPLC‐UV 0.15 to 19 µg / mL K EDTA ‐ Plasma 3 LC‐MS/MS Human Ticagrelor 2.5 to 1500 ng/mL K EDTA 90mg (Thermo) Plasma 2 341 LC‐MS/MS Human Deshydroxyethoxy Ticagrelor 1 to 300 ng/mL K EDTA 90mg (Thermo) Plasma 2 Human 342 Ticlopidine HPLC‐UV 10 to 1280 ng / mL K EDTA ‐ Plasma 3 LC‐MS/MS Human 343 Tofacitinib 0.2 to 100 ng/mL K EDTA 11 mg and 5 mg (Thermo) Plasma 2 Human LC‐MS/MS Plasma Sodium 344 Topiramate 5 to 2560 ng / mL 50 mg (API 3000) or Dog heparin Plasma LC‐MS/MS Human Sodium 345 Topiramate 50 to 12800 ng / mL 200 mg (API 3000) Plasma heparin LC‐MS/MS Human 25 mg/mL oral 346 Topiramate 2 to 1000 ng/mL K EDTA (Thermo) Plasma 2 solution LC‐MS/MS Human 347 Torsemide 10 to 10240 ng / mL K EDTA ‐ (API 300 or 3000) Plasma 3 HPLC Human 2.5 to 320 ng / mL K EDTA ‐ ‐ Flurosence Plasma 3 348 HPLC Human O‐Desmethyltramadol 2.5 to 320 ng / mL K EDTA ‐ ‐ Flurosence Plasma 3 Human Plasma LC‐MS/MS 349 Tramadol or 2 to 1024 ng / mL K EDTA 89 mg (API 3000) 2 Mouse Plasma NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

Human Plasma LC‐MS/MS O‐Desmethyltramadol or 1 to 512 ng / mL K EDTA ‐ (API 3000) 2 Mouse Plasma 350 Human Plasma LC‐MS/MS O,N‐di‐Desmethyltramadol or 1 to 512 ng / mL K EDTA ‐ (API 3000) 2 Mouse Plasma LC‐MS/MS Human Not Tramadol 0.2 to 50 µg / mL ‐ (API 3000) Urine applicable 351 LC‐MS/MS Human Not O‐Desmethyltramadol 0.05 to 12.5 µg / mL ‐ (API 3000) Urine applicable O,N‐di‐ LC‐MS/MS Human Not 351 0.05 to 12.5 µg / mL ‐ Desmethyltramadol (API 3000) Urine applicable LC‐MS/MS Dog Tramadol 2 to 1024 ng / mL K EDTA 89 mg (API 3000) Plasma 2 352 LC‐MS/MS Dog O‐Desmethyltramadol 1 to 512 ng / mL K EDTA ‐ (API 3000) Plasma 2 LC‐MS/MS Human Tramadol 2 to 1024 ng / mL K EDTA 89 mg (Thermo) Plasma 2 LC‐MS/MS Human O‐Desmethyltramadol 1 to 512 ng / mL K EDTA ‐ (Thermo) Plasma 2 353 O,N‐di‐ LC‐MS/MS Human 1 to 512 ng / mL K EDTA ‐ Desmethyltramadol (Thermo) Plasma 2 LC‐MS/MS Human Meloxicam 3.75 to 1920 ng / mL K EDTA ‐ (Thermo) Plasma 2 LC‐MS/MS Human 354 Tramadol 2 to 500 ng/mL K EDTA 100 mg (Thermo) Plasma 2 LC‐MS/MS Human 355 Tramadol 2 to 800 ng/mL K EDTA 200 mg (Thermo) Plasma 2 HPLC Human 356 10 to 2560 ng / mL Heparin ‐ ‐ Flurosence Plasma Triamcinolone LC‐MS/MS Human 357 0.025 to 6.4 ng/mL K EDTA 10 mg/mL acetonide (Thermo) Plasma 2 LC‐MS/MS Human 358 1 to 256 ng / mL K EDTA 96 mg (Thermo) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human 358 N‐Desmethyltrimbutine 10 to 2560 ng / mL K EDTA ‐ (Thermo) Plasma 2 U LC‐MS Human Ursodiol 100 to 12800 ng / mL K EDTA ‐ (API 150) Plasma 3 Glycoursodeoxycholic LC‐MS Human 359 150 to 19200 ng / mL K EDTA ‐ Acid (API 150) Plasma 3 Tauroursodeoxycholic LC‐MS Human 100 to 12800 ng / mL K EDTA ‐ Acid (API 150) Plasma 3 V LC‐MS/MS Human 360 Valsartan 20 to 10240 ng / mL K EDTA 160 mg (API 3000) Plasma 2 LC‐MS/MS Human 361 Valsartan 10 to 5000 ng/mL K EDTA 80 mg (Waters) Plasma 2 LC‐MS/MS Human Sodium 2 to 192 ng / mL 150 mg (API 3000) Plasma heparin 362 O‐ LC‐MS/MS Human Sodium 4 to 384 ng / mL ‐ Desmethylvenlafaxine (API 3000) Plasma heparin LC‐MS/MS Human Sodium Venlafaxine 1 to 600 ng/mL 300 mg (Thermo) Plasma heparin 363 Orthodesmethyl LC‐MS/MS Human Sodium 2 to 800 ng/mL ‐ Venlafaxine (Thermo) Plasma heparin LC‐MS/MS Human Sodium Venlafaxine 1 to 256 ng / mL 75 mg (API 3000) Plasma heparin O‐ LC‐MS/MS Human Sodium 2 to 512 ng / mL ‐ Desmethylvenlafaxine (API 3000) Plasma heparin N‐ LC‐MS/MS Human Sodium 364 1 to 256 ng / mL ‐ Desmethylvenlafaxine (API 3000) Plasma heparin N,O‐ LC‐MS/MS Human Sodium 1 to 256 ng / mL ‐ Didesmethylvenlafaxine (API 3000) Plasma heparin N,N,O‐ LC‐MS/MS Human Sodium 1 to 256 ng / mL ‐ Tridesmethylvenlafaxine (API 3000) Plasma heparin LC‐MS/MS Human Not Venlafaxine 0.1 to 13 µg / mL ‐ (API 300 or 3000) Urine applicable 365 LC‐MS/MS Human Not O‐Desmethylvenlafaxine 0.2 to 25 µg / mL ‐ (API 300 or 3000) Urine applicable NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES

Sr. Drug Name Instrument Matrix Range Anticoagulant Dose No.

LC‐MS/MS Human Not N‐Desmethylvenlafaxine 0.1 to 13 µg / mL ‐ (API 300 or 3000) Urine applicable N,O‐ LC‐MS/MS Human Not 365 0.2 to 25 µg / mL ‐ Didesmethylvenlafaxine (API 300 or 3000) Urine applicable N,N,O‐ LC‐MS/MS Human Not 0.1 to 13 µg / mL ‐ Tridesmethylvenlafaxine (API 300 or 3000) Urine applicable HPLC Human Verapamil 2 to 256 ng / mL K EDTA ‐ ‐ Flurosence Plasma 3 366 HPLC Human Norverapamil 2 to 256 ng / mL K EDTA ‐ ‐ Flurosence Plasma 3 LC‐MS/MS Human Sodium Verapamil 2 to 300 ng / mL 240 mg (Thermo) Plasma heparin 367 LC‐MS/MS Human Sodium Norverapamil 2 to 175 ng / mL ‐ (Thermo) Plasma heparin HPLC Human Verapamil (chiral) 1.6 to 102 ng / mL Heparin ‐ ‐ Flurosence Plasma 368 HPLC Human Norverapamil (chiral) 1.61 to 102 ng / mL Heparin ‐ ‐ Flurosence Plasma LC‐MS Human 369 Vigabatrin 0.2 to 25 µg / mL K EDTA ‐ (API 150) Plasma 2 W

LC‐MS/MS Human R‐Warfarin 1 to 512 ng / mL K EDTA ‐ (API 3000) Plasma 3 370 LC‐MS/MS Human S‐Warfarin 1 to 512 ng / mL K EDTA ‐ (API 3000) Plasma 3 Z LC‐MS/MS Human 371 0.125 to 64 ng / mL K EDTA 5 mg (API 3000) Plasma 2 LC‐MS/MS Human 372 Ziprasidone 0.5 to 256 ng / mL K EDTA 40 mg (API 3000) Plasma 2 LC‐MS/MS Human 0.2 to 20 ng/mL K EDTA 5mg Nasal spray (Thermo) Plasma 2 373 LC‐MS/MS Human N‐desmethyl Zolmitriptan 0.1 to 10 ng/mL K EDTA 5mg Nasal spray (Thermo) Plasma 2 HPLC Human 374 Zolpidem 1 to 512 ng / mL K EDTA 10 mg ‐ Flurosence Plasma 3