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US EPA Environmental Technology Verification Statement Removal of Chemical Contaminants in Drinking Water Watts Premier Inc
THE ENVIRONMENTAL TECHNOLOGY VERIFICATION PROGRAM U.S. Environmental Protection Agency NSF International ETV Joint Verification Statement TECHNOLOGY TYPE: POINT-OF-USE DRINKING WATER TREATMENT SYSTEM APPLICATION: REMOVAL OF CHEMICAL CONTAMINANTS IN DRINKING WATER PRODUCT NAME: WATTS PREMIER WP-4V COMPANY: WATTS PREMIER, INC. ADDRESS: 1725 WEST WILLIAMS DR. SUITE C-20 PHOENIX, AZ 85027 PHONE: 800-752-5582 NSF International (NSF) manages the Drinking Water Systems (DWS) Center under the U.S. Environmental Protection Agency’s (EPA) Environmental Technology Verification (ETV) Program. The DWS Center recently evaluated the performance of the Watts Premier WP-4V point-of-use (POU) drinking water treatment system. NSF performed all of the testing activities, and also authored the verification report and this verification statement. The verification report contains a comprehensive description of the test. EPA created the ETV Program to facilitate the deployment of innovative or improved environmental technologies through performance verification and dissemination of information. The goal of the ETV Program is to further environmental protection by accelerating the acceptance and use of improved and more cost-effective technologies. ETV seeks to achieve this goal by providing high-quality, peer- reviewed data on technology performance to those involved in the design, distribution, permitting, purchase, and use of environmental technologies. ETV works in partnership with recognized standards and testing organizations, stakeholder groups (consisting of buyers, vendor organizations, and permitters), and with the full participation of individual technology developers. The program evaluates the performance of innovative technologies by developing test plans that are responsive to the needs of stakeholders, conducting field or laboratory tests (as appropriate), collecting and analyzing data, and preparing peer reviewed reports. -
Emerging Technologies for Degradation of Dichlorvos: a Review
International Journal of Environmental Research and Public Health Review Emerging Technologies for Degradation of Dichlorvos: A Review Yuming Zhang 1,2, Wenping Zhang 1,2, Jiayi Li 1,2, Shimei Pang 1,2, Sandhya Mishra 1,2 , Pankaj Bhatt 1,2 , Daxing Zeng 3,* and Shaohua Chen 1,2,* 1 State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China; [email protected] (Y.Z.); [email protected] (W.Z.); [email protected] (J.L.); [email protected] (S.P.); [email protected] (S.M.); [email protected] (P.B.) 2 Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China 3 School of Applied Chemistry and Biological Technology, Shenzhen Polytechnic, Shenzhen 518055, China * Correspondence: [email protected] (D.Z.); [email protected] (S.C.); Tel.: +86-20-8528 8229 (S.C.) Abstract: Dichlorvos (O,O-dimethyl O-(2,2-dichlorovinyl)phosphate, DDVP) is a widely acknowl- edged broad-spectrum organophosphorus insecticide and acaracide. This pesticide has been used for more than four decades and is still in strong demand in many developing countries. Extensive application of DDVP in agriculture has caused severe hazardous impacts on living systems. The International Agency for Research on Cancer of the World Health Organization considered DDVP among the list of 2B carcinogens, which means a certain extent of cancer risk. Hence, removing DDVP from the environment has attracted worldwide attention. Many studies have tested the removal of DDVP using different kinds of physicochemical methods including gas phase surface discharge plasma, physical adsorption, hydrodynamic cavitation, and nanoparticles. -
Additive Interactions of Some Reduced-Risk Biocides and Two
www.nature.com/scientificreports OPEN Additive interactions of some reduced‑risk biocides and two entomopathogenic nematodes suggest implications for integrated control of Spodoptera litura (Lepidoptera: Noctuidae) Rashad Rasool Khan 1,2*, Muhammad Arshad 1*, Asad Aslam 3 & Muhammad Arshad 4 Higher volumes of conventional and novel chemical insecticides are applied by farmers to control resistant strains of armyworm (Spodoperta litura) in Pakistan without knowing their risks to the environment and to public health. Ten reduced‑risk insecticides were tested for their compatibility with two entomopathogenic nematodes (EPNs); Heterorhabditis indica and Steinernema carpocapsae rd against S. litura. The insecticide emamectin benzoate was highly toxic (LC50 = 2.97 mg/l) against 3 instar S. litura larvae when applied alone whereas, novaluron and methoxyfenozide were the least toxic (LC50 = 29.56 mg/l and 21.06 mg/l), respectively. All the insecticides proved harmless against the two EPNs even 96 h after treatment. Indoxacarb, fubendiamide and spinetoram produced the greatest mortalities (72–76%) of S. litura larvae after 72 h when applied in mixtures with H. indica. Lowest mortalities (44.00 ± 3.74% and 48.00 ± 2.89) were observed for mixtures of H. indica with methoxyfenozide and chlorfenapyr, respectively. The positive control treatments with both EPNs (S. carpocapsae and H. indica) produced > 50% mortality 96 h after treatment. For insecticide mixtures with S. carpocapsae, only indoxacarb produced 90% mortality of larvae, whereas, indoxacarb, fubendiamide, emamectin benzoate, and spinetoram produced 90–92% mortality of larvae when applied in mixtures with H. indica. Additive interactions (Chi‑square < 3.84) of EPN mixtures with reduced volumes of reduced‑risk insecticides suggest opportunities to develop more environmentally favorable pest management programs for S. -
Validation Report 20
EURL for Cereals and Feeding stuff National Food Institute Technical University of Denmark Validation Report 20 Determination of pesticide residues in rice baby food by GC-MS/MS and LC-MS/MS (QuEChERS method) Parvaneh Hajeb Susan Strange Herrmann Mette Erecius Poulsen December 2015 Page 2 of 18 CONTENT: 1. Introduction ...................................................................................................................................... 3 2. Principle of analysis......................................................................................................................... 3 3. Validation design ............................................................................................................................. 4 4. Chromatograms and calibration curves .......................................................................................... 5 5. Validation parameters...................................................................................................................... 9 6. Criteria for the acceptance of validation results ........................................................................... 10 7. Results and discussion ................................................................................................................... 10 8. Conclusions .................................................................................................................................... 12 9. References ..................................................................................................................................... -
Oxydemeton-Methyl (166) Demeton-S-Methyl (073
oxydemeton-methyl 993 OXYDEMETON-METHYL (166) DEMETON-S-METHYL (073) EXPLANATION Oxydemeton-methyl (ODM) was evaluated for residues by the JMPR in 1968, 1973, 1979, 1984, 1989, and 1992. The 1992 review was a complete re-evaluation. It reviewed extensive residue data from supervised trials on all major crops and associated data on use patterns, storage stability, processing, and methods of residue analysis were reviewed and numerous MRLs were recommended. The MRLs are expressed as the sum oxydemeton-methyl, demeton-S-methyl, and demeton-S- methylsulphon, expressed as oxydemeton-methyl. The ADI was established in 1989 at 0.0003 mg/kg body weight and is for the sum of the three compounds. Demeton-S-methyl is an insecticide. The sulfoxide of demeton-S-methyl is ODM. It currently has no MRLs. The 1995 CCPR scheduled ODM and demeton-S-methyl for periodic review of residue aspects by the 1997 JMPR (ALINORM 95/24A). This was changed by the 1997 CCPR, which scheduled ODM and demeton-S-methyl for periodic review by the 1998 JMPR. Bayer AG has submitted data in support of the Periodic Review which included information on crops and regions of interest to that company. The governments of Germany and The Netherlands have also submitted information. IDENTITY Common name (ISO): Oxydemeton-methyl Chemical name: IUPAC: S-2-ethylsulfinylethyl O,O-dimethyl phosphothioate CA: S-[2-ethylsulfinyl)ethyl] O,O-dimethyl phosphothioate CAS number: 301-12-2 EU-index number: 015-046-00-7 EINECS number: 206-110-7 CIPAC number: 171 Molecular formula: C6 H15 O4 P S2 Synonyms: Metasystox R Structural formula: . -
Florida State Emergency Response Commission
Florida State Emergency Response Commission Sub-Committee on Training (SOT) HAZARDOUS MATERIALS MEDICAL TREATMENT PROTOCOLS Version 3.3 TOXIDROMES Toxidromes are clinical syndromes that the patient presents with. These patterns of signs and symptoms are essential for the successful recognition of chemical exposure. The toxidromes identified in this protocol are chemical exposure based while others such as the opioids are found within general medical protocol. These chemical toxidromes are identified clinically into five syndromes: Irritant Gas Toxidrome Asphyxiant Toxidrome Corrosive Toxidrome Hydrocarbon and Halogenated Hydrocarbons Toxidrome Cholinergic Toxidrome Each can present as a clinical manifestation of the chemical/poisoning involved with some cross-over between toxidromes. This list combines the toxic syndromes found within NFPA 473 (A.5.4.1(2) and traditional syndromes. Toxidrome Correlation to NFPA Standard 473 and Traditional Syndromes Toxidrome NFPA 473 A.5.4.1(2) Hazardous Materials Protocol Correlation Irritant Gas (j) Irritants Bronchospasm OC Pepper spray & lacrimants Asphyxiant (c) Chemical asphyxiants Carbon Monoxide (d) Simple asphyxiants Aniline dyes, Nitriles, Nitrares (h) Blood Agents Cyanide & Hydrogen Sulfide (n) Nitrogen Compounds Closed Space Fires Simple Asphyxants Corrosive (a) Corrosives Hydrofluroic Acid (g) Vesicants Chemical burns to the eye Choramine and Chlorine Hydrocarbon (e) Organic solvents Phenol and (q) Phenolic Compounds Halogenated Hydrocarbons Halogenated Hydrocarbons Cholinergic (b) Pesticides -
Agents for Defense Against Chemical Warfare: Reactivators of Acetylcholinesterase Inhibited with Neurotoxic Organophosphorus Compounds **
Mil. Med. Sci. Lett. (Voj. Zdrav. Listy) 2015, vol. 84(3), p. 115-127 ISSN 0372-7025 DOI: 10.31482/mmsl.2015.013 REVIEW ARTICLE AGENTS FOR DEFENSE AGAINST CHEMICAL WARFARE: REACTIVATORS OF ACETYLCHOLINESTERASE INHIBITED WITH NEUROTOXIC ORGANOPHOSPHORUS COMPOUNDS ** Petronilho, E. C., Figueroa-Villar, J. D. Chemistry Engineering Section, Medicinal Chemistry Group, Military Institute of Engineering, Praça General Tibúrcio, 80, Urca, 22290-270, Rio de Janeiro, RJ, Brazil. Received 30 th April 2015. Revised 7 th July 2015. Published 4 th September 2015. Summary The chemical warfare agents and neurotoxic agents are an important threat to people all over the world, and require special attention because they are highly dangerous. Most of these agents are neurotoxic organophosphorus compounds (OP), which inhibit the enzyme acetylcholinesterase (AChE), which is responsible for controlling the transmission of nerve impulses. To be inhibited by these compounds, AChE can sometimes be reactivated using cationic oximes, which are the most used substances for this reactivation. Until today there have not been discovered agents for complete treatment of poisoning by all OPs. For this reason, the treatment of intoxicated people requires the determination of the absorbed OP, in order to select the appropriate activator, a process that usually requires long time and may cause death. Therefore, this study aims to do a review on the OPs used as chemical warfare agents and the process of inhibition and reactivation of AChE, especially to motivate the development of new agents for defense against chemical weapons, a process that is very important for protecting all humanity. Key words: acetylcholinesterase; AChE reactivators; organophosphorus; oximes; warfare agents INTRODUCTION pounds (OP), which are highly toxic, allowing their use with small quantities in order to cause seizures The use of chemical warfare agents is a major and death. -
EPA Method 538: Determination of Selected Organic Contaminants in Drinking Water with Direct Aqueous Injection LC/MS/MS
EPA Method 538: Determination of Selected Organic Contaminants in Drinking Water with Direct Aqueous Injection LC/MS/MS E. Michael Thurman and Imma Ferrer Center for Environmental Mass Spectrometry University of Colorado Boulder, CO, USA Confidentiality Label 1 March 20, 2012 Abstract EPA Method 538 is a new method from EPA for organophosphate pesticides in drinking water. It uses direct aqueous injection; thus, no sample preparation is needed. We use both UHPLC (Agilent 1290) and MS/MS (Agilent 6460) analysis for rapid analysis and sensitive detection with ng/L limits of detection. A second MRM is added for more reliable identification. Confidentiality Label 2 March 20, 2012 Hypothesis Direct injection of organophosphate pesticides (EPA Method 538) will work by UHPLC (Agilent Model 1290) and LC/MS/MS with Jetstream (Agilent Model 6460) with trace level detection at ng/L concentrations. Confidentiality Label 3 March 20, 2012 1. Introduction-Summary 1.1 EPA Method 538 (published in November 2009 by Shoemaker) deals with Organophosphate pesticides in drinking water (1) and one other contaminant, quinoline. 1.2 The method consists of 10 compounds: acephate, aldicarb, aldicarb sulfoxide, dicrotophos, diisopropylmethylphosphonate (DIMP), fenamiphos sulfone, fenamiphos sulfoxide, methamidophos, oxydemeton methyl, quinoline, and thiofanox with 5 labeled internal standards. 1.3 Direct aqueous injection is used with a large volume sample of 100 microliters; thus, no sample preparation is needed. 1.4 Because solid phase extraction (i.e. concentration of the sample is not carried out) suppression is mimimized in the analysis. 1.5 Part-per-Trillion Detection Limits. Confidentiality Label 4 March 20, 2012 Introduction 1.1: EPA Method 538: Determination of Selected Organic Contaminants in Drinking Water by Direct Aqueous Injection by Jody Shoemaker, EPA Cincinnati, OH [email protected] 513-569-7298 Confidentiality Label 5 March 20, 2012 Introduction: 1.2. -
Method 8141B
METHOD 8141B ORGANOPHOSPHORUS COMPOUNDS BY GAS CHROMATOGRAPHY 1.0 SCOPE AND APPLICATION 1.1 This method provides procedures for the gas chromatographic (GC) determination of organophosphorus (OP) compounds. The compounds listed in the table below can be determined by GC using capillary columns with a flame photometric detector (FPD) or a nitrogen-phosphorus detector (NPD). Triazine herbicides can also be determined with this method when the NPD is used. Although performance data are presented for each of the listed chemicals, it is unlikely that all of them could be determined in a single analysis. This limitation results because the chemical and chromatographic behavior of many of these chemicals can result in co-elution. The analyst must select columns, detectors, and calibration procedures for the specific analytes of interest. Any listed chemical is a potential method interference when it is not a target analyte. Analyte CAS Registry No. Organophosphorus Pesticides Asponb 3244-90-4 Azinphos-methyl 86-50-0 Azinphos-ethyla 2642-71-9 Bolstar (Sulprofos) 35400-43-2 Carbophenothiona 786-19-6 Chlorfenvinphosa 470-90-6 Chlorpyrifos 2921-88-2 Chlorpyrifos methyla 5598-13-0 Coumaphos 56-72-4 Crotoxyphosa 7700-17-6 Demeton-Oc 8065-48-3 Demeton-Sc 8065-48-3 Diazinon 333-41-5 Dichlorofenthiona 97-17-6 Dichlorvos (DDVP) 62-73-7 Dicrotophosa 141-66-2 Dimethoate 60-51-5 Dioxathiona,c 78-34-2 Disulfoton 298-04-4 EPN 2104-64-5 Ethiona 563-12-2 Ethoprop 13194-48-4 Famphura 52-85-7 8141B - 1 Revision 2 November 2000 Analyte CAS Registry No. Fenitrothiona -
EPA Method 538: Determination of Selected Organic Contaminants in Drinking Water by Aqueous Direct Injection and LC/MS/MS Summar
EPA Method 538: Determination of Selected Organic Contaminants in Drinking Water by Aqueous Direct Injection and LC/MS/MS UCT Part Numbers: SLAQ100ID21-3UM - Selectra® Aqueous C18, 100 x 2.1mm, 3µm SLAQGDC20-3UM - Selectra® Aqueous C18, Guard column, 10 x 2.0mm, 3µm SLGRDHLDR - Guard Cartridge Holder June 2015 Summary: This application outlines a direct aqueous injection-liquid chromatography/tandem mass spectrometry (DAI-LC/MS/MS) method for the determination of 11 selected organic contaminants in drinking water, including methamidophos, acephate, aldicarb sulfoxide, oxydemeton methyl, dicrotophos, aldicarb, diisopropyl methylphosphonate (DIMP), fenamiphos sulfone, fenamiphos sulfoxide, thiofanox, and quinoline [1]. Dicrotophos, oxydemeton methyl, methamidophos, and acephate are UCMR4 compounds. An Aqueous C18 HPLC column was utilized for analyte retention and separation. Calibration curves were constructed using calibration standards prepared in reagent water with preservative reagents for analyte quantitation. The responses were linear over the entire analytical ranges (R2 ≥ 0.9970). Excellent accuracy (90 - 111%) and precision (RSD% < 20%, n=7) were achieved for fortified reagent water and tap water samples. Procedure: 1. Preserve drinking water sample with 64 mg/L of sodium omadine (antimicrobial) and 1.5 g/L of ammonium acetate (binding free chlorine). 2. Mix 0.99 mL of the preserved water sample with 10 μL of 0.4-12.5 ng/μL internal standard mixture, and vortex for 30 sec. 3. Inject 50 μL onto LC/MS/MS equipped with an aqueous -
Organophosphate Poisoning : a Review
120 Sinha and Sharma Med J Indones Organophosphate poisoning : A review Parmod K. Sinha, Ashok Sharma Abstrak Pestisida organofosfat digunakan secara luas di seluruh dunia. Keracunan oleh bahan ini merupakan masalah kesehatan masyarakat, terutama di negara berkembang. Zat neurotoksik organofosfat merupakan bahan yang dianggap mengancam dalam bidang militer dan terorisme. Mekanisme toksisitas bahan ini adalah dengan cara menghambat asetilkolinesterase yang mengakibatkan menumpuknya neurotransmitor asetilkolin dan terjadi rangsangan terus-menerus pada reseptor asetilkolin pada sistem saraf sentral maupun perifer. Selain krisis kolinergik, organofosfat dapat menimbulkan berbagai sindrom neurologis, baik akut maupun kronik. Sedangkan gejala peralihan ( intermediate) terjadi 1-4 hari setelah krisis kolinergik teratasi. Pengobatan standar terdiri dari reaktivasi asetilkolinesterase dengan antidot golongan oksim (prolidoksim, oksidoksime, HI-6 dan HLo7), dan pengendalian efek biokimia asetilkolin dengan menggunakan atropin. Golongan oksim yang baru HI-6 dan Hlo7 merupakan reaktivator asetilkolinesterase yang lebih cocok dan efektif untuk keracunan akut dan berat dibandingkan dengan prolidoksim dan obidoksim. Penderita yang mendapat pengobatan segera, biasanya dapat sembuh dari toksisitas akut, namun gejala neurologis ikutan dapat saja terjadi. (Med J Indones 2003; 12: 120-6) Abstract Organophosphate pesticides are used extensively worldwide, and poisoning by these agents, particularly in developing nations is a public health problem. Organophosphorous -
Nerve Agent - Lntellipedia Page 1 Of9 Doc ID : 6637155 (U) Nerve Agent
This document is made available through the declassification efforts and research of John Greenewald, Jr., creator of: The Black Vault The Black Vault is the largest online Freedom of Information Act (FOIA) document clearinghouse in the world. The research efforts here are responsible for the declassification of MILLIONS of pages released by the U.S. Government & Military. Discover the Truth at: http://www.theblackvault.com Nerve Agent - lntellipedia Page 1 of9 Doc ID : 6637155 (U) Nerve Agent UNCLASSIFIED From lntellipedia Nerve Agents (also known as nerve gases, though these chemicals are liquid at room temperature) are a class of phosphorus-containing organic chemicals (organophosphates) that disrupt the mechanism by which nerves transfer messages to organs. The disruption is caused by blocking acetylcholinesterase, an enzyme that normally relaxes the activity of acetylcholine, a neurotransmitter. ...--------- --- -·---- - --- -·-- --- --- Contents • 1 Overview • 2 Biological Effects • 2.1 Mechanism of Action • 2.2 Antidotes • 3 Classes • 3.1 G-Series • 3.2 V-Series • 3.3 Novichok Agents • 3.4 Insecticides • 4 History • 4.1 The Discovery ofNerve Agents • 4.2 The Nazi Mass Production ofTabun • 4.3 Nerve Agents in Nazi Germany • 4.4 The Secret Gets Out • 4.5 Since World War II • 4.6 Ocean Disposal of Chemical Weapons • 5 Popular Culture • 6 References and External Links --------------- ----·-- - Overview As chemical weapons, they are classified as weapons of mass destruction by the United Nations according to UN Resolution 687, and their production and stockpiling was outlawed by the Chemical Weapons Convention of 1993; the Chemical Weapons Convention officially took effect on April 291997. Poisoning by a nerve agent leads to contraction of pupils, profuse salivation, convulsions, involuntary urination and defecation, and eventual death by asphyxiation as control is lost over respiratory muscles.