Profile Spotlight

Prof. Larry E. Overmann

Blakemore Research Group Presented by Subhash D. Tanpure 1 Prof. Larry E. Overmann

• Born in Chicago 1943 • BA Earlham College 1965 • PhD University of Wisconsin Madison 1969 with Dr. Howart Whitlock Jr. • Post Doc with Ronald Breslow at Columbia 1969-1971 • Joined faculty at UC Irvine 1971 • Distinguished Professor in Organic Chemistry at UC Irvine

2 Awards and Honors

• National Academy of Sciences, 1996; American Academy of Arts and Sciences, 1996 • Ryoji Noyori Prize, Society of Synthetic Organic Chemistry, Japan, 2015 • Roger Adams Award in Organic Chemistry, American Chemical Society, 2015; UCI Medal, • University of California, Irvine, 2011 • American Chemical Society, Herbert C. Brown Award for Creative Research in Synthetic Methods, 2010 • Tetrahedron Prize for Creativity in Organic Chemistry, 2008; The Nagoya Medal of Organic Chemistry, 2007 • International Society of Heterocyclic Chemistry Senior Award, 2005 • American Chemical Society Arthur C. Cope Award, 2003 • Yamada Prize, 2002 • American Chemical Society Award for Creative Work in Synthetic Organic Chemistry, 1995 • American Chemical Society Arthur C. Cope Scholar Award, 1989 • Camille and Henry Dreyfus Teacher-Scholar Award, 1976–1981 • U.C. Irvine School of Physical Sciences Distinguished Teaching Award, 1981 • U.C. Irvine Alumni Association Distinguished Research Award, 1979

3 Research Area

• Research in the Overman group centers on the invention of new transformations and strategies in organic synthesis

4 Research Area

• Total Synthesis of Natural Products

5 Research Area

Overmann Rearrangement

The Overman Rearrangement allows the conversion of readily available allylic alcohols into allylic amines by a two-step synthesis involving the rearrangement of an allylic trichloroacetimidate to an allylic trichloroacetamide with clean 1,3-transposition of the alkenyl moiety

Overmann, L. E., J. Am. Chem. Soc. 1974, 96, 597–599 6 Research Area

Aza-cope/ Manich Reaction (1979)

Homoallylic amine with allylic hydroxyl group gives 3 acylpyrrolidines

Overmann, L. E., J. Am. Chem. Soc. 1979, 101, 1310. Overmann, L. E., J. Am. Chem. Soc. 1988, 110, 4329 7 Research Area

Total Synthesis of Strychnine (1993)

Overmann, L. E., J. Am. Chem. Soc. 1993, 115, 9293. 8 Research Area

Total Synthesis of Strychnine (1993)

Overmann, L. E., J. Am. Chem. Soc. 1993, 115, 9293. 9 Recent Publication

Enantioselective Total Synthesis of Macfarlandin C, a Spongian Diterpenoid Harboring a Concave‐Substituted cis‐Dioxabicyclo[3.3.0]octanone Fragment

Overmann, L. E., J. Angew. Chem. 2020, early view 10