The 2005 Abbott Chemistry Lectures

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PREVIOUS The University of North Dakota GEORGE A. ABBOTT LECTURERS Department of Chemistry 1963 Dr. Nelson Leonard, University of Illinois invites you to 1964 Dr. Robert West, University of Wisconsin 1965 Dr. Robert Parry, University of Michigan The 2005 Abbott 1966 Dr. Ralph G. Pearson, Northwestern University 1967 Dr. Harold J. Bernstein, N.R.C. Ottawa, Canada Chemistry Lectures 1968 Dr. Edward L. King, University of Colorado 1969 Dr. David N. Hume, Mass. Institute of Technology 1970 Dr. Ronald Breslow, Columbia University 1971 Dr. Arnold C. Wahl, Argonne Laboratory 1972 Dr. John L. Margrave, Rice University 1973 Dr. Cheves Walling, University of Utah 1974 Dr. Fred McLafferty, Cornell University 1975 Dr. Daryle H. Busch, Ohio State University 1976 Dr. Hans H. Jaffe, University of Cincinnati 1977 Dr. Roald Hoffmann, Cornell University 1978 Dr. H.C. Brown, Purdue University 1979 Dr. Leo A. Paquette, Ohio State University 1980 Dr. Robert E. Sievers, University of Colorado 1981 Dr. Dietmar Seyferth, Mass. Institute of Technology 1982 Dr. Koji Nakanishi, Columbia University 1983 Dr. Melvin Calvin, University of California-Berkeley 1984 Dr. Gabor A. Somorjai, University of California-Berkeley 1985 Dr. Harry B. Gray, California Institute of Technology 1986 Dr. Allen J. Bard, University of Texas at Austin 1987 Dr. William J. Bailey, University of Maryland 1988 Dr. Mark S. Wrighton, Mass. Institute of Technology 1989 Dr. Peter B. Dervan, California Institute of Technology 1990 Dr. Robert H. Grubbs, California Institute of Technology 1991 Dr. Andrew Streitwieser, Univ. of California-Berkeley 1992 Dr. Marye Anne Fox, University of Texas at Austin 1994 Dr. Kendall N. Houk, University of California, LA 1995 Dr. Edward Yeung, Iowa State University 1997 Dr. Henry F. Schaefer, III , University of Georgia 1999 Dr. Tobin J. Marks, Northwestern University 2000 Dr. Alexander Pines, University of California-Berkeley April 21 & 22, 2005 2001 Dr. Paul A. Wender, Stanford University University of North Dakota Chemistry Department PO Box 9024 Grand Forks, ND 58202-9024 RETURN SERVICE REQUESTED 2002 Dr. Samuel H. Gellman, University of Wisconsin 2003 Dr. Victor J. Hruby, University of Arizona 2004 Dr. William Miller, University of California - Berkeley.

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Cell Circuitry || Science Teaches English || The Chicken Genome Is Hot || Magnets in Medicine SEPTEMBER 2002 www.hhmi.org/bulletin Leading Doublea Life It’s a stretch, but doctors who work bench to bedside say they wouldn’t do it any other way. FEATURES 14 On Human Terms 24 The Evolutionary War A small—some say too small—group of Efforts to undermine evolution education have physician-scientists believes the best science evolved into a 21st-century marketing cam- requires patient contact. paign that relies on legal acumen, manipulation By Marlene Cimons of scientific literature and grassroots tactics. 20 Engineering the Cell By Trisha Gura Adam Arkin sees the cell as a mechanical system. He hopes to transform molecular 28 Call of the Wild biology into a kind of cellular engineering Could quirky, new animal models help scien- and in the process, learn how to move cells tists learn how to regenerate human limbs or from sickness to health. avert the debilitating effects of a stroke? By M. Mitchell Waldrop By Kathryn Brown 24 In front of a crowd of 1,500, Ohio’s Board of Education heard testimony on whether students should learn about intelligent design in science class. DEPARTMENTS 2 NOTA BENE 33 PERSPECTIVE ulletin Intelligent Design Is a Cop-Out 4 LETTERS September 2002 || Volume 15 Number 3 NEWS AND NOTES HHMI TRUSTEES PRESIDENT’S LETTER 5 JAMES A. BAKER, III, ESQ. 34 Senior Partner, Baker & Botts A Creative Influence In from the Fields ALEXANDER G. BEARN, M.D. Executive Officer, American Philosophical Society 35 Lost on the Tip of the Tongue Adjunct Professor, The Rockefeller University UP FRONT Professor Emeritus of Medicine, Cornell University Medical College 36 Biology by Numbers FRANK WILLIAM GAY 6 Follow the Songbird Former President and Chief Executive Officer, SUMMA Corporation JAMES H.
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Fall 2019 SPECIAL DAY/TIME/LOCATION: Friday
The Chemistry and Biochemistry Departmental Seminar Series covers a broad range of fields in the Chemical and Biochemical Sciences. In past seminars, scientists from Academia, Government, and Industry have presented their most recent discoveries and contributions in their respective areas. This Seminar Series offers students and faculty the opportunity to interact directly with other leaders in their specializations and to gain a good overview of the entire range of fields in Chemistry and Biochemistry. Fall 2019 Seminars are held on Tuesdays in CL 1009 (Clendenin Building, Room 1009 on the Kennesaw Campus), 12:30 - 1:30pm, unless otherwise noted with special day/time/location information. All are invited to attend. SPECIAL DAY/TIME/LOCATION: Friday, September 20, 2019 – 2:30pm in CL 2003 Dr. Jeffrey I. Seeman, Department of Chemistry, University of Richmond Title: Was Plagiarism Involved in the Conceptualization of the Woodward-Hoffmann Rules? Abstract: In 1981, Roald Hoffmann and Kenichi Fukui shared the Nobel Prize in Chemistry “for their theories, developed independently, concerning the course of chemical reactions.” Had Robert B. Woodward (1917 – 1979) lived two years longer, he would surely have received his second Nobel Prize in Chemistry for his contributions to the Woodward-Hoffmann rules. In the March 29, 2004 issue of Chemical & Engineering News, E. J. Corey wrote in his Priestley Medal Address, “On May 4, 1964, I suggested to my colleague R. B. Woodward a simple explanation involving the symmetry of the perturbed (HOMO) molecular orbitals for the stereoselective cyclobutene/1,3-butadiene and 1,3,5-hexatriene/cyclohexadiene conversions that provided the basis for the further development of these ideas into what became known as the Woodward-Hoffmann rules.” Letters between Corey and Hoffmann in 1981 and 1984 and other relevant information will be shown and discussed.
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Nobel Lecture, 8 December 1981 by ROALD HOFFMANN Department of Chemistry, Cornell University, Ithaca, N.Y
BUILDING BRIDGES BETWEEN INORGANIC AND ORGANIC CHEMISTRY Nobel lecture, 8 December 1981 by ROALD HOFFMANN Department of Chemistry, Cornell University, Ithaca, N.Y. 14853 R. B. Woodward, a supreme patterner of chaos, was one of my teachers. I dedicate this lecture to him, for it is our collaboration on orbital symmetry conservation, the electronic factors which govern the course of chemical reac- tions, which is recognized by half of the 1981 Nobel Prize in Chemistry. From Woodward I learned much: the significance of the experimental stimulus to theory, the craft of constructing explanations, the importance of aesthetics in science. I will try to show you how these characteristics of chemical theory may be applied to the construction of conceptual bridges between inorganic and organic chemistry. FRAGMENTS Chains, rings, substituents - those are the building blocks of the marvelous edifice of modern organic chemistry. Any hydrocarbon may be constructed on paper from methyl groups, CH 3, methylenes, CH 2, methynes, CH, and carbon atoms, C. By substitution and the introduction of heteroatoms all of the skeletons and functional groupings imaginable, from ethane to tetrodotoxin, may be obtained. The last thirty years have witnessed a remarkable renaissance of inorganic chemistry, and the particular flowering of the field of transition metal organo- metallic chemistry. Scheme 1 shows a selection of some of the simpler creations of the laboratory in this rich and ever-growing field. Structures l-3 illustrate at a glance one remarkable feature of transition metal fragments. Here are three iron tricarbonyl complexes of organic moie- ties - cyclobutadiene, trimethylenemethane, an enol, hydroxybutadiene - which on their own would have little kinetic or thermodynamic stability.
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Nobel Laureates Endorse Joe Biden
Nobel Laureates endorse Joe Biden 81 American Nobel Laureates in Physics, Chemistry, and Medicine have signed this letter to express their support for former Vice President Joe Biden in the 2020 election for President of the United States. At no time in our nation’s history has there been a greater need for our leaders to appreciate the value of science in formulating public policy. During his long record of public service, Joe Biden has consistently demonstrated his willingness to listen to experts, his understanding of the value of international collaboration in research, and his respect for the contribution that immigrants make to the intellectual life of our country. As American citizens and as scientists, we wholeheartedly endorse Joe Biden for President. Name Category Prize Year Peter Agre Chemistry 2003 Sidney Altman Chemistry 1989 Frances H. Arnold Chemistry 2018 Paul Berg Chemistry 1980 Thomas R. Cech Chemistry 1989 Martin Chalfie Chemistry 2008 Elias James Corey Chemistry 1990 Joachim Frank Chemistry 2017 Walter Gilbert Chemistry 1980 John B. Goodenough Chemistry 2019 Alan Heeger Chemistry 2000 Dudley R. Herschbach Chemistry 1986 Roald Hoffmann Chemistry 1981 Brian K. Kobilka Chemistry 2012 Roger D. Kornberg Chemistry 2006 Robert J. Lefkowitz Chemistry 2012 Roderick MacKinnon Chemistry 2003 Paul L. Modrich Chemistry 2015 William E. Moerner Chemistry 2014 Mario J. Molina Chemistry 1995 Richard R. Schrock Chemistry 2005 K. Barry Sharpless Chemistry 2001 Sir James Fraser Stoddart Chemistry 2016 M. Stanley Whittingham Chemistry 2019 James P. Allison Medicine 2018 Richard Axel Medicine 2004 David Baltimore Medicine 1975 J. Michael Bishop Medicine 1989 Elizabeth H. Blackburn Medicine 2009 Michael S.
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Marye Anne Fox Papers
http://oac.cdlib.org/findaid/ark:/13030/c8fn19bp No online items Marye Anne Fox Papers Finding aid prepared by Special Collections & Archives, UC San Diego Special Collections & Archives, UC San Diego 9500 Gilman Drive La Jolla, California, 92093-0175 858-534-2533 [email protected] Copyright 2014 Marye Anne Fox Papers MSS 0764 1 Descriptive Summary Title: Marye Anne Fox Papers Identifier/Call Number: MSS 0764 Contributing Institution: Special Collections & Archives, UC San Diego 9500 Gilman Drive La Jolla, California, 92093-0175 Languages: English Physical Description: 2.0 Linear feet (5 archives boxes) Date (inclusive): 1969 - 2011 Abstract: The papers of physical organic chemist Marye Anne Fox, documenting her career as a researcher and professor. The collection dates from 1969-2011 and includes reprints, teaching files, subject files, notebooks, and grant proposals. Creator: Fox, Marye Anne, 1947- Scope and Content of Collection The papers of Marye Anne Fox, seventh chancellor of UC San Diego and National Medal of Science laureate, document her career as a researcher and professor of physical organic chemistry. The collection dates from 1969-2011 and is arranged in five series: 1) REPRINTS, 2) TEACHING FILES, 3) SUBJECT FILES, 4) NOTEBOOKS and 5) GRANT PROPOSALS. SERIES 1: REPRINTS The REPRINTS series contains most of Fox's published scientific articles from 1970-1999, arranged chronologically, including collaborative works with other researchers. Her research in the fields of organic photochemistry and electrochemistry has applications in solar energy, semiconductors, functional polymers, and environmental chemistry. SERIES 2: TEACHING FILES The TEACHING FILES series (1969-1993) includes notes, syllabi, problem sets, exam questions and departmental memoranda used by Fox while teaching advanced organic chemistry and photochemistry at the University of Texas, Austin.
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Date: To: September 22, 1 997 Mr Ian Johnston©
22-SEP-1997 16:36 NOBELSTIFTELSEN 4& 8 6603847 SID 01 NOBELSTIFTELSEN The Nobel Foundation TELEFAX Date: September 22, 1 997 To: Mr Ian Johnston© Company: Executive Office of the Secretary-General Fax no: 0091-2129633511 From: The Nobel Foundation Total number of pages: olO MESSAGE DearMrJohnstone, With reference to your fax and to our telephone conversation, I am enclosing the address list of all Nobel Prize laureates. Yours sincerely, Ingr BergstrSm Mailing address: Bos StU S-102 45 Stockholm. Sweden Strat itddrtSMi Suircfatan 14 Teleptelrtts: (-MB S) 663 » 20 Fsuc (*-«>!) «W Jg 47 22-SEP-1997 16:36 NOBELSTIFTELSEN 46 B S603847 SID 02 22-SEP-1997 16:35 NOBELSTIFTELSEN 46 8 6603847 SID 03 Professor Willis E, Lamb Jr Prof. Aleksandre M. Prokhorov Dr. Leo EsaJki 848 North Norris Avenue Russian Academy of Sciences University of Tsukuba TUCSON, AZ 857 19 Leninskii Prospect 14 Tsukuba USA MSOCOWV71 Ibaraki Ru s s I a 305 Japan 59* c>io Dr. Tsung Dao Lee Professor Hans A. Bethe Professor Antony Hewlsh Department of Physics Cornell University Cavendish Laboratory Columbia University ITHACA, NY 14853 University of Cambridge 538 West I20th Street USA CAMBRIDGE CB3 OHE NEW YORK, NY 10027 England USA S96 014 S ' Dr. Chen Ning Yang Professor Murray Gell-Mann ^ Professor Aage Bohr The Institute for Department of Physics Niels Bohr Institutet Theoretical Physics California Institute of Technology Blegdamsvej 17 State University of New York PASADENA, CA91125 DK-2100 KOPENHAMN 0 STONY BROOK, NY 11794 USA D anni ark USA 595 600 613 Professor Owen Chamberlain Professor Louis Neel ' Professor Ben Mottelson 6068 Margarldo Drive Membre de rinstitute Nordita OAKLAND, CA 946 IS 15 Rue Marcel-Allegot Blegdamsvej 17 USA F-92190 MEUDON-BELLEVUE DK-2100 KOPENHAMN 0 Frankrike D an m ar k 599 615 Professor Donald A.
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Melvin Calvin
M ELVIN C A L V I N The path of carbon in photosynthesis Nobel Lecture, December 11, 1961 Introduction It is almost sixty years since Emil Fischer was describing on a platform such as this one, some of the work which led to the basic knowledge of the struc- ture of glucose and its relatives 1 . Today we will be concerned with a de- scription of the experiments which have led to a knowledge of the principal reactions by which those carbohydrate structures are created by photo- synthetic organisms from carbon dioxide and water, using the energy of light. The speculations on the way in which carbohydrate was built from carbon dioxide began not long after the recognition of the basic reaction and were carried forward first by Justus von Liebig and then by Adolf von Baeyer and, finally, by Richard Willstätter and Arthur Stall into this century. Actually, the route by which animal organisms performed the reverse reaction, that is, the combustion of carbohydrate to carbon dioxide and water with the utili- zation of the energy resulting from this combination, turned out to be the first one to be successfully mapped, primarily by Otto Meyerhof 2 and Hans Krebs 3. Our own interest in the basic process of solar energy conversion by green plants, which is represented by the overall reaction began some time in the years between 1935 and 1937, during my post- doctoral studies with Professor Michael Polanyi at Manchester. It was there I first became conscious of the remarkable properties of coordinated metal compounds, particularly metalloporphyrins as represented by heme and chlorophyll.
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Spring 2015 Message from the Chair Chemistry Welcomes New Faculty Member Dr
CHEM Discovery chemistry.clemson.edu Spring 2015 Message from the Chair CHEMISTRY WELCOMES NEW FACULTY MEMBER DR. CARLOS GARCIA I hope that your spirits have been re- freshed and renewed by the arrival of Spring. This is the season that brings forth budding hopes and promises of Dr. Carlos Garcia is the newest rejuvenation and new growth even addition to our program and joined though T. S. Eliot tells us “April is the the Department of Chemistry in cruelest month, … mixing memory and August of 2015. Dr. Garcia’s desire”. research lies at the interface between microfluidics and nanomaterials and is focused on the development of The faculty’s hard work over the years novel analytical has blossomed into a number of awards. strategies to The New England Regional Section of d e t e r m i n e the Society for Applied Spectroscopy biomedically- announced that Professor Ken Marcus r e l e v a n t will receive the 2015 Lester W. Strock molecules. Dr. Award at its national meeting in Sep- retiring, the department is in the midst Garcia’s group tember for “the development of the of a search for two new instructors. will continue liquid sampling-atmospheric pressure i n v e s t i g a t i n g glow discharge ionization source”. Pro- In August 2014, the department held a the driving fessor Emeritus Dwaine Eubanks was retreat to develop a new strategic plan forces and awarded the George C. Pimentel Award and a re-examination of both the un- consequences in Chemical Education for his work as dergraduate and graduate programs in of the interaction of proteins with director of the ACS Examinations In- chemistry was conducted during the nanostructured surfaces and in stitute and his work in developing text- current academic year.
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Robert Burns Woodward
The Life and Achievements of Robert Burns Woodward Long Literature Seminar July 13, 2009 Erika A. Crane “The structure known, but not yet accessible by synthesis, is to the chemist what the unclimbed mountain, the uncharted sea, the untilled ﬁeld, the unreached planet, are to other men. The achievement of the objective in itself cannot but thrill all chemists, who even before they know the details of the journey can apprehend from their own experience the joys and elations, the disappointments and false hopes, the obstacles overcome, the frustrations subdued, which they experienced who traversed a road to the goal. The unique challenge which chemical synthesis provides for the creative imagination and the skilled hand ensures that it will endure as long as men write books, paint pictures, and fashion things which are beautiful, or practical, or both.” “Art and Science in the Synthesis of Organic Compounds: Retrospect and Prospect,” in Pointers and Pathways in Research (Bombay:CIBA of India, 1963). Robert Burns Woodward • Graduated from MIT with his Ph.D. in chemistry at the age of 20 Woodward taught by example and captivated • A tenured professor at Harvard by the age of 29 the young... “Woodward largely taught principles and values. He showed us by • Published 196 papers before his death at age example and precept that if anything is worth 62 doing, it should be done intelligently, intensely • Received 24 honorary degrees and passionately.” • Received 26 medals & awards including the -Daniel Kemp National Medal of Science in 1964, the Nobel Prize in 1965, and he was one of the ﬁrst recipients of the Arthur C.
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Good Chemistry James J
Columbia College Fall 2012 TODAY Good Chemistry James J. Valentini Transitions from Longtime Professor to Dean of the College your Contents columbia connection. COVER STORY FEATURES The perfect midtown location: 40 The Home • Network with Columbia alumni Front • Attend exciting events and programs Ai-jen Poo ’96 gives domes- • Dine with a client tic workers a voice. • Conduct business meetings BY NATHALIE ALONSO ’08 • Take advantage of overnight rooms and so much more. 28 Stand and Deliver Joel Klein ’67’s extraordi- nary career as an attorney, educator and reformer. BY CHRIS BURRELL 18 Good Chemistry James J. Valentini transitions from longtime professor of chemistry to Dean of the College. Meet him in this Q&A with CCT Editor Alex Sachare ’71. 34 The Open Mind of Richard Heffner ’46 APPLY FOR The venerable PBS host MEMBERSHIP TODAY! provides a forum for guests 15 WEST 43 STREET to examine, question and NEW YORK, NY 10036 disagree. TEL: 212.719.0380 BY THOMAS VIncIGUERRA ’85, in residence at The Princeton Club ’86J, ’90 GSAS of New York www.columbiaclub.org COVER: LESLIE JEAN-BART ’76, ’77J; BACK COVER: COLIN SULLIVAN ’11 WITHIN THE FAMILY DEPARTMENTS ALUMNI NEWS Déjà Vu All Over Again or 49 Message from the CCAA President The Start of Something New? Kyra Tirana Barry ’87 on the successful inaugural summer of alumni- ete Mangurian is the 10th head football coach since there, the methods to achieve that goal. The goal will happen if sponsored internships. I came to Columbia as a freshman in 1967. (Yes, we you do the other things along the way.” were “freshmen” then, not “first-years,” and we even Still, there’s no substitute for the goal, what Mangurian calls 50 Bookshelf wore beanies during Orientation — but that’s a story the “W word.” for another time.) Since then, Columbia has compiled “The bottom line is winning,” he said.
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Documenting the Biotechnology Industry in the San Francisco Bay Area
Documenting the Biotechnology Industry In the San Francisco Bay Area Robin L. Chandler Head, Archives and Special Collections UCSF Library and Center for Knowledge Management 1997 1 Table of Contents Project Goals……………………………………………………………………….p. 3 Participants Interviewed………………………………………………………….p. 4 I. Documenting Biotechnology in the San Francisco Bay Area……………..p. 5 The Emergence of An Industry Developments at the University of California since the mid-1970s Developments in Biotech Companies since mid-1970s Collaborations between Universities and Biotech Companies University Training Programs Preparing Students for Careers in the Biotechnology Industry II. Appraisal Guidelines for Records Generated by Scientists in the University and the Biotechnology Industry………………………. p. 33 Why Preserve the Records of Biotechnology? Research Records to Preserve Records Management at the University of California Records Keeping at Biotech Companies III. Collecting and Preserving Records in Biotechnology…………………….p. 48 Potential Users of Biotechnology Archives Approaches to Documenting the Field of Biotechnology Project Recommendations 2 Project Goals The University of California, San Francisco (UCSF) Library & Center for Knowledge Management and the Bancroft Library at the University of California, Berkeley (UCB) are collaborating in a year-long project beginning in December 1996 to document the impact of biotechnology in the Bay Area. The collaborative effort is focused upon the development of an archival collecting model for the field of biotechnology to acquire original papers, manuscripts and records from selected individuals, organizations and corporations as well as coordinating with the effort to capture oral history interviews with many biotechnology pioneers. This project combines the strengths of the existing UCSF Biotechnology Archives and the UCB Program in the History of the Biological Sciences and Biotechnology and will contribute to an overall picture of the growth and impact of biotechnology in the Bay Area.
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The Future of Life
Second Annual John H. Chafee Memorial Lecture on Science and the Environment The Future of Life Dr. Edward O. Wilson Pellegrino University Research Professor, Harvard University December 6, 2001 THE NATIONAL COUNCIL FOR SCIENCE AND THE ENVIRONMENT (NCSE) has been working since 1990 to improve the scientific basis of environmental decisionmaking and has earned an impressive reputa- tion for objectivity, responsibility, and achievement. The Council envisions a society where environmental decisions are based on an accurate understanding of the underlying science, its meaning, and its limitations. In such a society, citizens and decisionmakers receive accurate, understandable, and integrated science-based information. They understand the risks, uncertainties, and potential consequences of their action or inaction. Supported by over 500 academic, scientific, environmental, and business organizations, and federal, state, and local government, NCSE works closely with the many communities creating and using environmental knowledge to make and shape environmental decisions. The Council operates a range of innovative activities in the areas of: Promoting Science for the Environment The Council played an instrumental role in stimulating the National Science Foundation initiative to triple its annual budget for environmental research, education, and scientific assessment. The Council presents expert testimony to Congressional committees, consults regularly with key decisionmakers in government, and works to promote funding for environmental programs at numerous federal agencies. Enhancing Programs at Institutions of Higher Learning NCSE brings members of the academic community together to improve their environmental programs and increase their value to society through the University Affiliate Program, the Council of Environ- mental Deans and Directors, and the Minority Programs Office.
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