Steven C. Zimmerman Roger Adams Professor of Chemistry
Total Page：16
File Type：pdf, Size：1020Kb
Load more
Recommended publications
-
Download Issue
Cell Circuitry || Science Teaches English || The Chicken Genome Is Hot || Magnets in Medicine SEPTEMBER 2002 www.hhmi.org/bulletin Leading Doublea Life It’s a stretch, but doctors who work bench to bedside say they wouldn’t do it any other way. FEATURES 14 On Human Terms 24 The Evolutionary War A small—some say too small—group of Efforts to undermine evolution education have physician-scientists believes the best science evolved into a 21st-century marketing cam- requires patient contact. paign that relies on legal acumen, manipulation By Marlene Cimons of scientific literature and grassroots tactics. 20 Engineering the Cell By Trisha Gura Adam Arkin sees the cell as a mechanical system. He hopes to transform molecular 28 Call of the Wild biology into a kind of cellular engineering Could quirky, new animal models help scien- and in the process, learn how to move cells tists learn how to regenerate human limbs or from sickness to health. avert the debilitating effects of a stroke? By M. Mitchell Waldrop By Kathryn Brown 24 In front of a crowd of 1,500, Ohio’s Board of Education heard testimony on whether students should learn about intelligent design in science class. DEPARTMENTS 2 NOTA BENE 33 PERSPECTIVE ulletin Intelligent Design Is a Cop-Out 4 LETTERS September 2002 || Volume 15 Number 3 NEWS AND NOTES HHMI TRUSTEES PRESIDENT’S LETTER 5 JAMES A. BAKER, III, ESQ. 34 Senior Partner, Baker & Botts A Creative Influence In from the Fields ALEXANDER G. BEARN, M.D. Executive Officer, American Philosophical Society 35 Lost on the Tip of the Tongue Adjunct Professor, The Rockefeller University UP FRONT Professor Emeritus of Medicine, Cornell University Medical College 36 Biology by Numbers FRANK WILLIAM GAY 6 Follow the Songbird Former President and Chief Executive Officer, SUMMA Corporation JAMES H. -
1 Fundamentals of Polymer Chemistry
1 Fundamentals of Polymer Chemistry H. Warson 1 THE CONCEPT OF A POLYMER 1.1 Historical introduction The differences between the properties of crystalline organic materials of low molecular weight and the more indefinable class of materials referred to by Graham in 1861 as ‘colloids’ has long engaged the attention of chemists. This class includes natural substances such as gum acacia, which in solution are unable to pass through a semi-permeable membrane. Rubber is also included among this class of material. The idea that the distinguishing feature of colloids was that they had a much higher molecular weight than crystalline substances came fairly slowly. Until the work of Raoult, who developed the cryoscopic method of estimating molecular weight, and Van’t Hoff, who enunciated the solution laws, it was difficult to estimate even approximately the polymeric state of materials. It also seems that in the nineteenth century there was little idea that a colloid could consist, not of a product of fixed molecular weight, but of molecules of a broad band of molecular weights with essentially the same repeat units in each. Vague ideas of partial valence unfortunately derived from inorganic chem- istry and a preoccupation with the idea of ring formation persisted until after 1920. In addition chemists did not realise that a process such as ozonisation virtually destroyed a polymer as such, and the molecular weight of the ozonide, for example of rubber, had no bearing on the original molecular weight. The theory that polymers are built up of chain formulae was vigorously advocated by Staudinger from 1920 onwards [1]. -
Molecular Tweezers for Lysine and Arginine –
Volume 52 Number 76 1 October 2016 Pages 11307–11452 ChemComm Chemical Communications www.rsc.org/chemcomm ISSN 1359-7345 FEATURE ARTICLE Thomas Schrader, Gal Bitan and Frank-Gerrit Klärner Molecular tweezers for lysine and arginine – powerful inhibitors of pathologic protein aggregation ChemComm View Article Online FEATURE ARTICLE View Journal | View Issue Molecular tweezers for lysine and arginine – powerful inhibitors of pathologic protein aggregation Cite this: Chem. Commun., 2016, 52, 11318 a b a Thomas Schrader,* Gal Bitan* and Frank-Gerrit Kla¨rner* Molecular tweezers represent the first class of artificial receptor molecules that have made the way from a supramolecular host to a drug candidate with promising results in animal tests. Due to their unique structure, only lysine and arginine are well complexed with exquisite selectivity by a threading mechanism, which unites electrostatic, hydrophobic and dispersive attraction. However, tweezer design must avoid self-dimerization, self-inclusion and external guest binding. Moderate affinities of molecular tweezers towards sterically well accessible basic amino acids with fast on and off rates protect normal proteins from potential interference with their biological function. However, the early stages of Received 2nd June 2016, abnormal Ab, a-synuclein, and TTR assembly are redirected upon tweezer binding towards the Accepted 27th July 2016 generation of amorphous non-toxic materials that can be degraded by the intracellular and extracellular Creative Commons Attribution-NonCommercial 3.0 Unported Licence. DOI: 10.1039/c6cc04640a clearance mechanisms. Thus, specific host–guest chemistry between aggregation-prone proteins and lysine/arginine binders rescues cell viability and restores animal health in models of AD, PD, and www.rsc.org/chemcomm TTR amyloidosis. -
Chemistry Courses 2005-2006
Chemistry Courses 2005-2006 Autumn 2005 Chem 11101 General Chemistry I, Variant A Lee Chem 11102 General Chemistry I, Variant B Norris Chem 12200 Honors General Chemistry I Levy Chem 22000 Organic Chemistry I Yu Chem 22300 Intermediate Organic Chemistry Mrksich Chem 26100 Quantum Mechanics Mazziotti Chem 30100 Advanced Inorganic Chemistry Hopkins Chem 30900 Bioinorganic Chemistry He Chem 32100 Physical Organic Chemistry I Ismagilov Chem 32200 Organic Synthesis and Structure Rawal Chem 32600 Protein Fundamentals Piccirilli Chem 36100 Wave Mechanics & Spectroscopy Butler Chem 36400 Chemical Thermodynamics Dinner Winter 2006 Chem 11201 General Chemistry II, Variant A Scherer Chem 11202 General Chemistry II, Variant B Butler Chem 12300 Honors General Chemistry II Dinner Chem 20100 Inorganic Chemistry I Hillhouse Chem 22100 Organic Chemistry II Rawal Chem 23100 Honors Organic Chemistry II Kozmin Chem 26200 Thermodynamics Norris Chem 26700 Experimental Physical Chemistry Levy Chem 30200 Synthesis & Physical Methods in Inorganic Chemistry Jordan Chem 30400 Organometallic Chemistry Bosnich Chem 32300 Tactics of Organic Synthesis Yamamoto Chem 32400 Physical Organic Chemistry II Mrksich Chem 36200 Quantum Mechanics Freed Chem 36300 Statistical Mechanics Mazziotti Chem 38700 Biophysical Chemistry Lee Spring 2006 Chem 11301 General Chemistry III, Variant A Kozmin Chem 11302 General Chemistry III, Variant B Guyot-Sionnest Chem 20200 Inorganic Chemistry II Jordan Chem 22200 Organic Chemistry III Kent Chem 23200 Honors Organic Chemistry III Yamamoto Chem 22700 Advanced Organic / Inorganic Laboratory (8 students) He Chem 26300 Chemical Kinetics and Dynamics Sibner Chem 26800 Computational Chemistry & Biology Freed Chem 30600 Chemistry of the Elements Hillhouse Chem 31100 Supramolecular Chemistry Bosnich Chem 32500 Bioorganic Chemistry Piccirilli Chem 32900 Polymer Chemistry Yu Chem 33000 Complex Systems Ismagilov Chem 36500 Chemical Dynamics Scherer Chem 36800 Advanced Computational Chemistry & Biology Freed . -
Herbert Charles Brown, a Biographical Memoir
NATIONAL ACADEMY OF SCIENCES H E R B E R T Ch ARLES BROWN 1 9 1 2 — 2 0 0 4 A Biographical Memoir by E I-I CH I N EGIS HI Any opinions expressed in this memoir are those of the author and do not necessarily reflect the views of the National Academy of Sciences. Biographical Memoir COPYRIGHT 2008 NATIONAL ACADEMY OF SCIENCES WASHINGTON, D.C. Photograph Credit Here. HERBERT CHARLES BROWN May 22, 1912–December 19, 2004 BY EI -ICH I NEGISHI ERBERT CHARLES BROWN, R. B. Wetherill Research Profes- Hsor Emeritus of Purdue University and one of the truly pioneering giants in the field of organic-organometallic chemistry, died of a heart attack on December 19, 2004, at age 92. As it so happened, this author visited him at his home to discuss with him an urgent chemistry-related matter only about 10 hours before his death. For his age he appeared well, showing no sign of his sudden death the next morn- ing. His wife, Sarah Baylen Brown, 89, followed him on May 29, 2005. They were survived by their only child, Charles A. Brown of Hitachi Ltd. and his family. H. C. Brown shared the Nobel Prize in Chemistry in 1979 with G. Wittig of Heidelberg, Germany. Their pioneering explorations of boron chemistry and phosphorus chemistry, respectively, were recognized. Aside from several biochemists, including V. du Vigneaud in 1955, H. C. Brown was only the second American organic chemist to win a Nobel Prize behind R. B. Woodward, in 1965. His several most significant contribu- tions in the area of boron chemistry include (1) codiscovery of sodium borohyride (1972[1], pp. -
Company Update Company
October 30, 2017 OUTPERFORM Indorama Ventures (IVL TB) Share Price: Bt45.75 Target Price: Bt55.0 (+20.2%) Company Update Company Ready to take it all . 65% of newly acquired BOPET is HVA, underscoring healthy EBITDA margins in FY18F onward . M&G’s bankruptcy is an opportunity for IVL to gain more market share in North America . OUTPERFORM, raised TP to Bt55/sh; share price weakness upon weak 3Q17 results is an opportunity to buy IVL could become a major player of BOPET Early this month, IVL signed a share purchase agreement with DuPont Teijin Films (DTF) to acquire 100% stake in their PET film business. This marks an important step for IVL to diversify into PET film used in packaging, industrial, electrical, imaging, and magnetic media. 65% of Naphat CHANTARASEREKUL DTF’s products is ‘thick’ film, which commands the same EBITDA 662 - 659 7000 ext 5000 margin as IVL’s HVA portfolio of automotive and hygiene products. DTF [email protected] COMPANY RESEARCH | RESEARCH COMPANY is a leading producer of biaxially oriented Polyethylene Terephthalate (BOPET) and Polyethylene Naphthalate (PEN). Their business Key Data comprises of eight production assets in the US, Europe, and China with 12-mth High/Low (Bt) 46.5 / 28.25 global innovation center in UK with annual capacity of 277k tons. PET Market capital (Btm/US$m) 239,957/ 7,205 film uses the same feedstock as PET but the market is small at 4.1m ton 3m avg Turnover (Btm/US$m) 747.8 / 22.5 consumption p.a. We are optimistic IVL could become a major player in Free Float (%) 29.5 this market. -
Alumni Newsletter
ALUMNI NEWSLETTER SCHOOL OF CHEMICAL SCIENCES UNIVERSITY OF ILLINOIS at Urbana-Champaign NO. 11, WINTER 1976-77 The State of the Union (Comments by H. S. Gutowsky, director of the School of Chemical Sciences) Following the tradition of the last three issues of the Alumni Newsletter, I have put together a synopsis of some selected material that appears in much more detail in the 1975-76 Annual Report of the School of Chemical Sci ences and is not covered elsewhere in this issue. If you would like more details, let me know and I will be happy to forward you a copy of the com plete annual report. Instructional Program Two steps were taken dw·ing the past year to address the fact that 75 per cent or more of our chemistry graduates take positions in industry without learning much in their programs about the nature of industrial careers. Professor Peter Beak organized a special topics course, Chemistry 433, Re search in Industry, given in the fall semester. Early in the course, Dr. J. K. Stille from the University of Iowa presented a series of ten lectures on the fundamentals of industrial and polymer chemistry. This was followed by eleven weekly lectures from industrial speakers active in chemical roles. The program attracted a good deal of interest among our students and staff and its beneficial effects were visible to industrial recruiters interviewing here near its end. The second step was the inauguration of a cooperative program with Monsanto Company (St. Louis) for the summer employment of graduate students. Three entering graduate students participated in the summer of 1976, and it is hoped to extend the program to a larger number of students (and other companies) as well as to faculty next summer. -
1 DANIELA R. RADU, Ph.D
DANIELA R. RADU, Ph.D. Associate Professor, Mechanical and Materials Engineering, College of Engineering and Computing Florida International University, 10555 West Flagler Street, Miami, FL 33174 Tel. (O): (305) 348-4506 | Email: [email protected] EDUCATION Ph.D. in Chemistry (2004) Iowa State University, Ames, IA, USA Advisor: Professor Victor S.-Y. Lin M.S. in Chemistry (1996) “Babes-Bolyai” University, Cluj-Napoca, Romania Advisor: Professor Paul S. Agachi B.S. in Chemical Engineering (1994) “Babes-Bolyai” University, Cluj-Napoca, Romania Thesis Advisor: Professor Paul S. Agachi PROFESSIONAL EXPERIENCE Associate Professor with Tenure Department of Mechanical and Materials Engineering Florida International University, Miami, FL 33174 August 2018 – Present Associate Dean College of Mathematics, Natural Sciences and Technology January 2018 – July 2018 Delaware State University, Dover, DE Associate Professor with Tenure Department of Chemistry, Delaware State University, Dover, DE August 2017 – July 2018 Affiliated Professor Department of Materials Science and Engineering, University of Delaware October 2015 – Present Newark, DE Assistant Professor, Tenure-Track Department of Chemistry, Delaware State University, Dover, DE January 2013 – July2017 Senior Research Scientist DuPont CR&D, Experimental Station, Wilmington, DE August 2010 – December 2012 Research Scientist DuPont Central Research and Development, Experimental Station October 2007 – July 2010 Wilmington, DE Postdoctoral Research Fellow The Scripps Research Institute, La Jolla, CA -
Curriculum of Department of Pharmacy (6-Year Program)
Curriculum of Department of Pharmacy (6-year program) 1st year 2nd year 3rd year 4th year 5th year 6th year Basic Subjects for Pharmacy Student; Lectures and Practices of Basic Specialized Lectures and Practices Drug Therapy and its Related Practical Training and Beginning of Research for Graduation and SGL and more Sciences Research for Graduation Advanced Lectures Fundamental Education Professional Education Ⅰ Professional Education Ⅱ ■Humanism ■Humanism ■Preparatory Pharmacy Education ■Professional Pharmacy Education ■Practical Training ■Advanced Education Introduction to Humanism I Introduction to Humanism Ⅱ English for Pharmacy Oriental Medicine Preparation for Practical Training Research for Graduation Pharmacotherapeutics Practical Training in Hospital Advanced Clinical Training ■Preparatory Pharmacy Education ■Professional Pharmacy Education Drug Information Science Practical Training in Community Phrarmacy General Pharmacy Practice II ■Introduction of Pharmacy Basic English and English for Pharmacy Clinical Chemistry Drug Development and Production Japanese Traditional Medicine Invitation to Pharmacy Basic Statistics Synthesis of Target Molecules Pharmacy and Society ■Advanced Education Clinical Pharmacokinetics Early Exposure to Pharmacy Practical Trainings for Pharmacy Bioorganic Chemistry General Pharmacy Practice Research for Graduation Clinical Drug Evaluation Students Pharmaceutical Health Care Training Medical Economy Natural Products Chemistry ■Practical Training Education Drug Safty Evaluation and Pharmacoepidemiology -
Origins of Life: Transition from Geochemistry to Biogeochemistry
December 2016 Volume 12, Number 6 ISSN 1811-5209 Origins of Life: Transition from Geochemistry to Biogeochemistry NITA SAHAI and HUSSEIN KADDOUR, Guest Editors Transition from Geochemistry to Biogeochemistry Staging Life: Warm Seltzer Ocean Incubating Life: Prebiotic Sources Foundation Stones to Life Prebiotic Metal-Organic Catalysts Protometabolism and Early Protocells pub_elements_oct16_1300&icpms_Mise en page 1 13-Sep-16 3:39 PM Page 1 Reproducibility High Resolution igh spatial H Resolution High mass The New Generation Ion Microprobe for Path-breaking Advances in Geoscience U-Pb dating in 91500 zircon, RF-plasma O- source Addressing the growing demand for small scale, high resolution, in situ isotopic measurements at high precision and productivity, CAMECA introduces the IMS 1300-HR³, successor of the internationally acclaimed IMS 1280-HR, and KLEORA which is derived from the IMS 1300-HR³ and is fully optimized for advanced U-Th-Pb mineral dating. • New high brightness RF-plasma ion source greatly improving spatial resolution, reproducibility and throughput • New automated sample loading system with motorized sample height adjustment, significantly increasing analysis precision, ease-of-use and productivity • New UV-light microscope for enhanced optical image resolution (developed by University of Wisconsin, USA) ... and more! Visit www.cameca.com or email [email protected] to request IMS 1300-HR³ and KLEORA product brochures. Laser-Ablation ICP-MS ~ now with CAMECA ~ The Attom ES provides speed and sensitivity optimized for the most demanding LA-ICP-MS applications. Corr. Pb 207-206 - U (238) Recent advances in laser ablation technology have improved signal 2SE error per sample - Pb (206) Combined samples 0.076121 +/- 0.002345 - Pb (207) to background ratios and washout times. -
SCF and CI Studies on Ground State of Water Molecule
Ab initio SCF and CI studies on the ground state of the water molecule. II. Potential energy and property surfaces Bruce J. Rosenberg, Walter C. Ermler, and Isaiah Shavitt Citation: J. Chem. Phys. 65, 4072 (1976); doi: 10.1063/1.432861 View online: http://dx.doi.org/10.1063/1.432861 View Table of Contents: http://jcp.aip.org/resource/1/JCPSA6/v65/i10 Published by the American Institute of Physics. Additional information on J. Chem. Phys. Journal Homepage: http://jcp.aip.org/ Journal Information: http://jcp.aip.org/about/about_the_journal Top downloads: http://jcp.aip.org/features/most_downloaded Information for Authors: http://jcp.aip.org/authors Downloaded 29 Apr 2013 to 134.76.213.205. This article is copyrighted as indicated in the abstract. Reuse of AIP content is subject to the terms at: http://jcp.aip.org/about/rights_and_permissions Ab initio SCF and CI studies on the ground state of the water molecule. II. Potential energy and property surfaces Bruce J. Rosenberg* and Walter C. Ermlert Department of Chemistry. The Ohio State University. Columbus. Ohio 43210 Isaiah Shavitt Department of Chemistry. The Ohio State University. Columbus. Ohio 43210 and Battelle Memorial Institute. Columbus. Ohio 43201 (Received 29 June 1976) Self-consistent field and configuration interaction calculations for the energy and one-electron properties of the ground state of the water molecule were carried out with a (5s4p2d/3s1p) 39-function STO basis set. The CI treatment included all single and double excitation configurations (SD) relative to the SCF configuration. and a simple formula due to Davidson was used to estimate the energy contribution of quadruple excitations and thus produce a set of corrected (SDQ) energies. -
Design, Synthesis, and Testing of Bis-Corannulene Receptors for Fullerenes Based On
Automated Template C: Created by James Nail 2013V2.1 Design, synthesis, and testing of bis-corannulene receptors for fullerenes based on Klärner’s tethers By Peumie Luckshika Abeyratne Kuragama A Dissertation Submitted to the Faculty of Mississippi State University in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy in Chemistry in the Department of Chemistry Mississippi State, Mississippi December 2015 Copyright by Peumie Luckshika Abeyratne Kuragama 2015 Design, synthesis, and testing of bis-corannulene receptors for fullerenes based on Klärner’s tethers By Peumie Luckshika Abeyratne Kuragama Approved: ____________________________________ Andrzej Sygula (Major Professor) ____________________________________ Keith T. Mead (Committee Member) ____________________________________ Todd E. Mlsna (Committee Member) ____________________________________ Dongmao Zhang (Committee Member) ____________________________________ Stephen C. Foster (Graduate Coordinator/Committee Member) ____________________________________ R. Gregory Dunaway Dean College of Arts & Sciences Name: Peumie Luckshika Abeyratne Kuragama Date of Degree: December 11, 2015 Institution: Mississippi State University Major Field: Chemistry Major Professor: Andrzej Sygula Title of Study: Design, synthesis, and testing of bis-corannulene receptors for fullerenes based on Klärner’s tethers Pages in Study: 141 Candidate for Degree of Doctor of Philosophy The discovery of the new allotropic forms of elemental carbon (e.g. fullerenes and carbon nanotubes)