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Amplification of Oxidative Stress by a Dual Stimuli-Responsive Hybrid Drug
ARTICLE Received 11 Jul 2014 | Accepted 12 Mar 2015 | Published 20 Apr 2015 DOI: 10.1038/ncomms7907 Amplification of oxidative stress by a dual stimuli-responsive hybrid drug enhances cancer cell death Joungyoun Noh1, Byeongsu Kwon2, Eunji Han2, Minhyung Park2, Wonseok Yang2, Wooram Cho2, Wooyoung Yoo2, Gilson Khang1,2 & Dongwon Lee1,2 Cancer cells, compared with normal cells, are under oxidative stress associated with the increased generation of reactive oxygen species (ROS) including H2O2 and are also susceptible to further ROS insults. Cancer cells adapt to oxidative stress by upregulating antioxidant systems such as glutathione to counteract the damaging effects of ROS. Therefore, the elevation of oxidative stress preferentially in cancer cells by depleting glutathione or generating ROS is a logical therapeutic strategy for the development of anticancer drugs. Here we report a dual stimuli-responsive hybrid anticancer drug QCA, which can be activated by H2O2 and acidic pH to release glutathione-scavenging quinone methide and ROS-generating cinnamaldehyde, respectively, in cancer cells. Quinone methide and cinnamaldehyde act in a synergistic manner to amplify oxidative stress, leading to preferential killing of cancer cells in vitro and in vivo. We therefore anticipate that QCA has promising potential as an anticancer therapeutic agent. 1 Department of Polymer Á Nano Science and Technology, Polymer Fusion Research Center, Chonbuk National University, Backje-daero 567, Jeonju 561-756, Korea. 2 Department of BIN Convergence Technology, Chonbuk National University, Backje-daero 567, Jeonju 561-756, Korea. Correspondence and requests for materials should be addressed to D.L. (email: [email protected]). NATURE COMMUNICATIONS | 6:6907 | DOI: 10.1038/ncomms7907 | www.nature.com/naturecommunications 1 & 2015 Macmillan Publishers Limited. -
Examining the Technology for a Sustainable Environment Grant Program
Examining the Technology for a Sustainable Environment Grant Program An Interactive Qualifying Project Report Submitted to the Faculty of WORCESTER POLYTECHNIC INSTIUTE In partial fulfillment of the requirements for the Degree of Bachelor of Science Submitted to: Professor James Demetry Professor Joseph Petruccelli Worcester Polytechnic Institute: Washington, D.C. Project Center By: Eddie Diaz _____________________ Melissa Hinton _____________________ Mark Stevenson _____________________ December 13, 2004 In Cooperation with the Environmental Protection Agency Diana Bauer, Ph.D April Richards, PE National Center of National Center of Environmental Research Environmental Research Environmental Protection Environmental Protection Agency Agency Washington, DC 20005 Washington, DC 20005 This report is submitted in partial fulfillment of the degree requirements of Worcester Polytechnic Institute. The views and opinions expressed herein are those of the authors and do not necessarily reflect the positions or opinions of the Environmental Protection Agency or Worcester Polytechnic Institute. Abstract This project was performed with the support of the Environmental Protection Agency and involved the examination of the Technology for a Sustainable Environment (TSE) grants program. We selected ten researchers funded by the TSE program, interviewed them, and reviewed their research in terms of qualitative and quantitative academic, industrial, and potential environmental impacts. For each of the ten researchers, we wove this information together -
With Organic Oxalates Ching Ching (Chua) Ong Iowa State University
Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 1969 Part I. Gas phase pyrolysis of organic oxalates, Part II. Reactions of chromium(II) with organic oxalates Ching Ching (Chua) Ong Iowa State University Follow this and additional works at: https://lib.dr.iastate.edu/rtd Part of the Organic Chemistry Commons Recommended Citation Ong, Ching Ching (Chua), "Part I. Gas phase pyrolysis of organic oxalates, Part II. Reactions of chromium(II) with organic oxalates" (1969). Retrospective Theses and Dissertations. 4679. https://lib.dr.iastate.edu/rtd/4679 This Dissertation is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. This dissertation has been microfilmed exactly as received 69-15,637 ONG, Ching Ching (Chua), 1941- PART I. GAS PHASE PYROLYSIS OF ORGANIC OXALATES. PART II. REACTIONS OF CHROMIUM (II) WITH ORGANIC OXALATES. Iowa State University, Ph.D., 1969 Chemistry, organic University Microfilms, Inc., Ann Arbor, Michigan PART I. GAS PHASE PYROLYSIS OF ORGANIC OXALATES PART II. REACTIONS OF CHROMIUM(II) WITH ORGANIC OXALATES by Ching Ching (Chua) Ong A Dissertation Submitted to the Graduate Faculty in Partial Fulfillment of Tîie Requirements for the Degree of DOCTOR OF PHILOSOPHY Major Subject: Organic Chemistry Approved: Signature was redacted for privacy. In Charge of Major Work Signature was redacted for privacy. Signature was redacted for privacy. Iowa State University Ames, Iowa 1969 ii TABLE OF CONTENTS Page PART I. -
Good Chemistry James J
Columbia College Fall 2012 TODAY Good Chemistry James J. Valentini Transitions from Longtime Professor to Dean of the College your Contents columbia connection. COVER STORY FEATURES The perfect midtown location: 40 The Home • Network with Columbia alumni Front • Attend exciting events and programs Ai-jen Poo ’96 gives domes- • Dine with a client tic workers a voice. • Conduct business meetings BY NATHALIE ALONSO ’08 • Take advantage of overnight rooms and so much more. 28 Stand and Deliver Joel Klein ’67’s extraordi- nary career as an attorney, educator and reformer. BY CHRIS BURRELL 18 Good Chemistry James J. Valentini transitions from longtime professor of chemistry to Dean of the College. Meet him in this Q&A with CCT Editor Alex Sachare ’71. 34 The Open Mind of Richard Heffner ’46 APPLY FOR The venerable PBS host MEMBERSHIP TODAY! provides a forum for guests 15 WEST 43 STREET to examine, question and NEW YORK, NY 10036 disagree. TEL: 212.719.0380 BY THOMAS VIncIGUERRA ’85, in residence at The Princeton Club ’86J, ’90 GSAS of New York www.columbiaclub.org COVER: LESLIE JEAN-BART ’76, ’77J; BACK COVER: COLIN SULLIVAN ’11 WITHIN THE FAMILY DEPARTMENTS ALUMNI NEWS Déjà Vu All Over Again or 49 Message from the CCAA President The Start of Something New? Kyra Tirana Barry ’87 on the successful inaugural summer of alumni- ete Mangurian is the 10th head football coach since there, the methods to achieve that goal. The goal will happen if sponsored internships. I came to Columbia as a freshman in 1967. (Yes, we you do the other things along the way.” were “freshmen” then, not “first-years,” and we even Still, there’s no substitute for the goal, what Mangurian calls 50 Bookshelf wore beanies during Orientation — but that’s a story the “W word.” for another time.) Since then, Columbia has compiled “The bottom line is winning,” he said. -
From Cationic Ring-Opening Polymerization to Atom Transfer Radical Polymerization
24 2014,,59 nr 1 From cationic ring-opening polymerization to atom transfer radical polymerization Krzysztof Matyjaszewski* DOI: dx.doi.org/10.14314/polimery.2014.024 Dedicated to Professor Stanislaw Penczek on the occasion of his 80th birthday Abstract: Roots of controlled radical polymerization, including atom transfer radical polymerization (ATRP), origi- nate in living ionic polymerizations accompanied by reversible deactivation, such as cationic ring-opening polymeri- zation of tetrahydrofuran and other heterocyclics. Recent developments in ATRP, including mechanistic understan- ding, synthesis of polymers with precisely controlled architecture and some applications of polymers prepared by ATRP are presented. Keywords: cationic ring-opening polymerization, tetrahydrofuran, atom transfer radical polymerization, ATRP,con- trolled radical polymerization, block copolymers. Od kationowej polimeryzacji z otwarciem pierœcienia do polimeryzacji rodniko- wej z przeniesieniem atomu Streszczenie: Artyku³ stanowi przegl¹d literaturowy dotycz¹cy kontrolowanej polimeryzacji rodnikowej, w tym w szczególnoœci kontrolowanej polimeryzacji rodnikowej z przeniesieniem atomu (ATRP), wywodz¹cej siê z jono- wej polimeryzacji ¿yj¹cej, której towarzyszy odwracalna dezaktywacja. Omówiono rozwój wspomnianych metod polimeryzacji, monomery, inicjatory i warunki reakcji syntezy polimerów o precyzyjnie kontrolowanej architektu- rze, a tak¿e zastosowanie materia³ów o ró¿norodnych w³aœciwoœciach, uzyskiwanych z wykorzystaniem ATRP. S³owa kluczowe: kationowa polimeryzacja -
THE NINETY-THIRD PRESENTATION of the WILLARD GIBBS MEDAL (Founded by William A
http:/chicagoacs.org MAY• 2004 THE NINETY-THIRD PRESENTATION OF THE WILLARD GIBBS MEDAL (Founded by William A. Converse) to PROFESSOR RONALD BRESLOW sponsored by the CHICAGO SECTION AMERICAN CHEMICAL SOCIETY FRIDAY, MAY 21, 2004 North Shore Lights at The iation for a nametag , and your check. Acceptance of the Award Hotel Moraine Be sure to include your address. 700 North Sheridan Road Tables fo r ten are availab le. If you Highwood, Illinois would like a table for a group, please 847-433-6366 put the ir names on a separate sheet and include it with your registration. DIRECTIONS TO THE MEETING From the North or South: Take 1-294 (continued on page 2) (the TriState Tollway) to Route 22. Exit east, take it to Route 41 (Skokie Hwy). AWARD CEREMONY 8:30 P.M. Turn north to the next exit, Old Elm. Go east on Old Elm to Sheridan Road Oust The Willard Gibbs Medal across some railroad tracks) . Turn right/south for 3/4 mile. The hotel is on Milt Levenberg, Chair the right. Chicago Section, ACS From Downtown: Take the Kennedy Introduction of the Medalist Expressway north. At the split , follow the Edens Expressway , which turns Madeleine Jacobs Executive Director & CEO, ACS into Skokie Highway past Lake Cook Dr. Ronald Breslow Road. Continue north to Old Elm Road. Presentation of the Medal Samuel Latham Mitchill Professor of Turn right/east on Old Elm and follow Chemistry and University Professor the directions above to the hotel. Dr. Charles P. Casey Department of Chemistry President, ACS Columbia University Parking: Free New York, NY RECEPTION 6:00-7:00 P.M. -
15/5/40 Liberal Arts and Sciences Chemistry Irwin C. Gunsalus Papers, 1877-1993 BIOGRAPHICAL NOTE Irwin C
15/5/40 Liberal Arts and Sciences Chemistry Irwin C. Gunsalus Papers, 1877-1993 BIOGRAPHICAL NOTE Irwin C. Gunsalus 1912 Born in South Dakota, son of Irwin Clyde and Anna Shea Gunsalus 1935 B.S. in Bacteriology, Cornell University 1937 M.S. in Bacteriology, Cornell University 1940 Ph.D. in Bacteriology, Cornell University 1940-44 Assistant Professor of Bacteriology, Cornell University 1944-46 Associate Professor of Bacteriology, Cornell University 1946-47 Professor of Bacteriology, Cornell University 1947-50 Professor of Bacteriology, Indiana University 1949 John Simon Guggenheim Fellow 1950-55 Professor of Microbiology, University of Illinois 1955-82 Professor of Biochemistry, University of Illinois 1955-66 Head of Division of Biochemistry, University of Illinois 1959 John Simon Guggenheim Fellow 1959-60 Research sabbatical, Institut Edmund de Rothchild, Paris 1962 Patent granted for lipoic acid 1965- Member of National Academy of Sciences 1968 John Simon Guggenheim Fellow 1972-76 Member Levis Faculty Center Board of Directors 1977-78 Research sabbatical, Institut Edmund de Rothchild, Paris 1973-75 President of Levis Faculty Center Board of Directors 1978-81 Chairman of National Academy of Sciences, Section of Biochemistry 1982- Professor of Biochemistry, Emeritus, University of Illinois 1984 Honorary Doctorate, Indiana University 15/5/40 2 Box Contents List Box Contents Box Number Biographical and Personal Biographical Materials, 1967-1995 1 Personal Finances, 1961-65 1-2 Publications, Studies and Reports Journals and Reports, 1955-68 -
Program for the 20Th
TWENTIETH NATIONAL ORGANIC CHEMISTRY SYMPOSIUM of the AMERICAN CHEMICAL SOCIETY AUSPICES OF TIlE DIVISION OF ORGANIC CHEMISTRY THE UNIVERSITY OF VERMONT and the WESTERN VERMONT SECTION OF THE ACS * June 18-22, 1967 Burlington, Vermont TWENTIETH NATIONAL ORGANIC CHEMISTRY SYMPOSIUM of the AMERICAN CHEMICAL SOCIETY a'lf Speakers at the Twentieth National Organic Symposium A" <" ,V C'r<i> ' F. A. L. Anet o. L. Chapman G. L. Closs G. S. Hammond H. O. House R. Pettit R. B. Woodward P. R. Schleyer H. E. Simmons PROGRAM SUNDAY, JUNE 18 Registration: Patrick Gymnasium, 2:00-11 :00 P.M. MONDAY, JUNE 19 Registration and Meetings: Patrick Gymnasium 9:00 A.M. Welcome. CLINTON D. COOK, Vice President, University of Vermont Response. GILBERT STORK, Chair man, Division of Organic Chemistry, ACS 9:30 A.M. PAUL von R. SCHLEYER, "Structure and Reactivity in Carbonium Ion Reactions" 11:00 A.M. R. PETTIT, "The Chemistry of Cyclobutadiene-lron Carbonyl Complexes" 8:00 P.M. "Chemical Approaches to Enzyme Mechanisms" WILLIAM P. JENCKS, "Acetoacetyl CoA: Succinate Coenzyme A Transferase" E. T. KAISER, "Enzyme Chemistry of Highly Reactive Cyclic Esters" TUESDAY, JUNE 20 9:00 A.M. HOWARD E. SIMMONS, "Macrobi cyclic Amines" 10:30 A.M. G. L. CLOSS, "Mechanisms of Carbe noid Reactions" 8:00 P.M. JOHN D. ROBERTS, Roger Adams Award Address, "Some Problems Re lating to the Calculation of Steric Effects in Simple Molecules" 9:30 P.M. Social Hour WEDNESDAY, JUNE 21 9:00 A.M. F. A. L. ANET, "Conformational and Valency Isomerism in Eight-Membered Rings" 10:30 A.M. -
The Carnegie Mellon Chemist • •
The Carnegie Mellon Chemist CHEMISTRY ALUMNI NEWSLETTER •••• CARNEGIE MELLON UNIVERSITY DEPARTMENT OF CHEMISTRY January 1999 Chemistry Undergrads John A. Pople Awarded Richard M. Cyert Nobel Chemistry Prize 1998 Graduating Class We are The word that John Pople re- Richard M. Cyert made seminal pleased to report that twenty five ceived the 1998 Nobel Prize in contributions to the development of students received undergraduate Chemistry will surely have reached Carnegie Mellon as we know it today. degrees in Chemistry in the May most of our Alumni by now. As they These were remembered in a Memo- 1998 commencement. Eight of will know, the work cited by the Nobel rial Service on the campus on Nov. 9 these graduated with University Prize Committee was done while in McConomy Auditorium. Cyert Honors, and four received MCS John was a member of the CMU De- succumbed to a long illness on Oct. Honors. Seven were inducted into partment of Chemistry from 1964 7, at the age of 77. Speakers at the the Phi Beta Kappa Honor Society through 1993. The Prize was shared service included President Jared L. and six into Phi Kappa Phi.The com- with Walter Kohn, who did part of the Cohon, daughter Martha Cyert, and mencement was the first for Presi- work cited while in the Department of current and past members of the fac- dent Cohon, and also the first in the Physics of CMU, before he joined ulty and administration who had setting of Gesling Stadium. Con- the University of California at Santa worked with Cyert. President Cohon struction of Purnell Center, the new Barbara in 1960. -
The 2009 Abbott Chemistry Lectures
George A. Abbott, 1874-1973 Dr. George Alonzo Abbott, Professor Emeritus at the University of North Dakota, had a long and fruitful career of service to the State of North Dakota and the science of Chemistry. He was born July 7, 1874, in Alma, Illinois. Dr. Abbott received both the B.S. and M.A. pro merito from DePauw University. From 1896 until 1904 he taught chemistry in high schools in Evansville, Indiana; Duluth, Minnesota; and Indianapolis, Indiana. In 1903, through a contact with Professor Talbot, he received the Austen Research Fellowship at Massachusetts Institute of Technology. Under the guidance of A. A. Noyes, Professor of Physical Chemistry at M.I.T., he received the Ph.D. in 1908. In this first class of doctorates in chemistry were such notables as Edward Washburn, Charles Kraus and Richard Tolman. Dr. Abbott joined the chemistry staff of the North Dakota Agricultural College (North Dakota State University) in 1909. In 1910 he was appointed Professor and Chairman of the Department of Chemistry at the University of North Dakota. His devotion to teaching and the application of chemistry for the betterment of North Dakota was one of his outstanding contributions. His interests in quality water and in natural products such as lignite, for which North Dakota is recognized, gave him national recognition. For half a century he was the only toxicologist in a wide area of the upper midwest. He found time to do a weekly radio program “Science from the Sidelines” which was broadcast for over twenty years. Professor Abbott was a founder and charter member of the North Dakota Academy of Science. -
News Release
NEWS RELEASE Date: August 15, 2016 From: The Kosciuszko Foundation, Pittsburgh Chapter Contact: Mary Lou Ellena [email protected] 412.855.8330 -- FOR IMMEDIATE RELEASE -- CMU Professor Selected to Receive “Outstanding Polonian” Award Pittsburgh, PA -- The Pittsburgh Chapter of the Kosciuszko Foundation will present its annual Outstanding Polonian Award to Carnegie-Mellon Professor Krzysztof Matyjaszewski, PhD at a luncheon to be held Saturday, September 17, 2016. As a Distinguished Professor in the Department of Chemistry within CMU’s Mellon College of Science, Dr. Matyjaszewski is an internationally recognized polymer chemist who is renowned for his vision, educational leadership and research innovation. His discovery of Atom Radical Transfer Polymerization (ATRP) led to significant innovations in the field of polymer chemistry and revolutionized how macromolecules are made. Macromolecules are necessary for life and include carbohydrates, lipids, nucleic acids, and proteins. Dr. Matyjaszewski has received considerable international recognition for his contributions to science. In 2004 he received the annual prize of the Foundation of Polish Science, often referred to as the "Polish Nobel Prize.” In 2005 he became a foreign member of the Polish Academy of Science and in 2007 received an honorary degree from Lodz Polytechnic (Poland). IN recognition of his accomplishments the Polish Chemical Society awarded him the Marie Sklodowska-Curie Medal in 2012. He has received honorary degrees from the University of Ghent (Belgium), the Russian Academy of Sciences, the University of Athens (Greece), the Polytechnic Institute of Toulouse (France), the Pusan National University (South Korea) and the Université Pierre et Marie Curie, Sorbonne (France). Most recently Professor Matyjaszewski joined a research team at CMU under a $3 million grant to provide the US Military with drones, gliders and other delivery vehicles that can “vanish” once they safely deliver supplies or intelligence to troops. -
BIOLOGY 639 SCIENCE ONLINE the Unexpected Brains Behind Blood Vessel Growth 641 THIS WEEK in SCIENCE 668 U.K
4 February 2005 Vol. 307 No. 5710 Pages 629–796 $10 07%.'+%#%+& 2416'+0(70%6+10 37#06+6#6+8' 51(69#4' #/2.+(+%#6+10 %'..$+1.1); %.10+0) /+%41#44#;5 #0#.;5+5 #0#.;5+5 2%4 51.76+105 Finish first with a superior species. 50% faster real-time results with FullVelocity™ QPCR Kits! Our FullVelocity™ master mixes use a novel enzyme species to deliver Superior Performance vs. Taq -Based Reagents FullVelocity™ Taq -Based real-time results faster than conventional reagents. With a simple change Reagent Kits Reagent Kits Enzyme species High-speed Thermus to the thermal profile on your existing real-time PCR system, the archaeal Fast time to results FullVelocity technology provides you high-speed amplification without Enzyme thermostability dUTP incorporation requiring any special equipment or re-optimization. SYBR® Green tolerance Price per reaction $$$ • Fast, economical • Efficient, specific and • Probe and SYBR® results sensitive Green chemistries Need More Information? Give Us A Call: Ask Us About These Great Products: Stratagene USA and Canada Stratagene Europe FullVelocity™ QPCR Master Mix* 600561 Order: (800) 424-5444 x3 Order: 00800-7000-7000 FullVelocity™ QRT-PCR Master Mix* 600562 Technical Services: (800) 894-1304 Technical Services: 00800-7400-7400 FullVelocity™ SYBR® Green QPCR Master Mix 600581 FullVelocity™ SYBR® Green QRT-PCR Master Mix 600582 Stratagene Japan K.K. *U.S. Patent Nos. 6,528,254, 6,548,250, and patents pending. Order: 03-5159-2060 Purchase of these products is accompanied by a license to use them in the Polymerase Chain Reaction (PCR) Technical Services: 03-5159-2070 process in conjunction with a thermal cycler whose use in the automated performance of the PCR process is YYYUVTCVCIGPGEQO covered by the up-front license fee, either by payment to Applied Biosystems or as purchased, i.e., an authorized thermal cycler.