A Newsletter for Contributors to the ACS Cycle of Excellence Volume 2 / Issue 1 / Spring 2008

In This Issue: s2OBERT*-ASSIE2ECEIVES-ILES#ONRAD!WARD sCRT,AUNCHESA.EW7EBSITE s)NTERVIEWWITHACR%DITOR*OAN36ALENTINE sACS Nano Indexed in Leading Scientific Databases s!#3.ANOTATION'OES,IVE sJOC Introduces Featured Articles s"IOCHEMISTRY)NTRODUCES2APID2EPORTS s7%/SnAN)NTERVIEWWITH0ROFESSOR(ENRY2ZEPA s!#3.ATIONAL!WARDS0ROGRAM s!#3%DITOR$ELEGATION4RAVELSTO#HINA s#!33CIENCE3POTLIGHT-OST2EQUESTED!RTICLES And more...

A Supplement to ACS Publications EXCELLENCE VOL. 2 - ISSUE 1 - SPRING 2008

❂ A Message from ACS Publications As we embark on our second volume of Excellence, we begin with congratulations to our colleague Brian D. Crawford, who since the publication of our last issue, was named as the new President of American Publications, succeeding Robert D. Bovenschulte, who retired in August of 2007.

Other news from the program includes new content types for a number of ACS Publications, starting with the journal featured on our cover, The Robert J. Massie Brian D. Crawford Journal of Organic (JOC). JOC is making headlines in 2008 with ❂ #ONGRATULATIONSTO2OBERT the introduction of JOC Featured Articles; Chemical Research in Toxicology has broadened its *-ASSIEFOR2ECEIVING-ILES scope with the recent additions of Global Perspectives, In This Issue and Spotlights; announced the new Rapid Reports articles to capture timely topics of unusual interest; Accounts #ONRAD!WARD of Chemical Research replaced their traditional article abstract with an article “Conspectus.” These are just a few of the initiatives designed to not only capture the best and brightest research being On February 25, 2008, Robert published in chemistry and the related sciences, but also to captivate the best and brightest minds J. Massie, President of the ACS’ in those fields as well. Chemical Abstracts Service (CAS), was presented the prestigious 2008 also marks another year of significant milestones for ACS Publications, highlighted by the Miles Conrad Award by the 100th anniversary of Industrial & Engineering Chemistry Research, the 80th volume of Analytical Chemistry, the 40th anniversary of Accounts of Chemical Research, 20th anniversaries for National Federation of Advanced Chemistry of Materials, and Chemical Research in Toxicology, the 10th volume for Organic Letters Information Services (NFAIS) at and the Journal of Combinatorial Chemistry, and volume number 5 for Molecular Pharmaceutics. the NFAIS Annual Conference and Join us in thanking and congratulating the current editors of these journals, most of whom are 50th Anniversary celebration in the founding editors of these, some of the leading journals in their respective fields. Philadelphia. The award recognizes and honors those members of the We would also be remiss if we did not extend and reaffirm our appreciation to you for your information community who have continued support and contributions to ACS Publications, as it truly is your commitment to excellence that makes our journals the most-cited in chemistry and the related sciences. made significant contributions to the field of information science and We hope that you find the information herein useful, and request that you contact us at to NFAIS itself. ACS Publications [email protected] with any suggestions for future issues or questions about anything congratulates Robert Massie on this related to this printed newsletter, the Excellence Website at http://pubs.acs.org/acs/excellence/ well-deserved recognition of his or the ACS Publications program. outstanding leadership of CAS and his contributions to the information Best Regards, industry. (See page 6 for CAS Science Sean Abell, Editor, Excellence Spotlight Most Requested Articles from ACS Publications).

[email protected]

On the cover: 0ACLITAXELFROM0RIMARY4AXANES!0ERSPECTIVEON#REATIVE The Journal of )NVENTIONIN/RGANOZIRCONIUM#HEMISTRY Organic Chemistry Bruce Ganem and Roland R. Franke; pp 3981 - 3987; (Perspective); DOI: 10.1021/jo070129s Vol. 72, Issue 11 May 25, 2007 The image illustrates recent developments in taxane chemistry. A university team developed novel organozirconium chemistry and, in an industrial collaboration, achieved an improved preparation of the blockbuster anti-cancer drug paclitaxel. The recurring scissors theme in the light bulb signifies the central amide cleavage reaction by which a mixture of primary taxanes is transformed to a common intermediate, which leads to paclitaxel. Stylized yew trees composed of molecular structures suggest the common, nursery-grown ornamental yews from which paclitaxel can now be produced. See Ganem and Franke, JOC Volume 72, Issue 11, page 3981. Bruce Ganem is the recipient of the 2007 ACS Award for Creative Invention. (see page 13)

The Journal of Organic Chemistry is the most cited journal in Organic Chemistry. For more information on the journal see page 6.

01 HTTPPUBSACSORGJOC ❂ Celebrating its 20th Anniversary, CRT,AUNCHESA.EW7EBSITE %XPANDED3COPE AND.EW&EATURES

As Chemical Research in Toxicology celebrates 20 years of “CRT has celebrated 20 years of high- publication, it looks forward to continued service of the quality publication but is completely toxicology community with a broadened scope of molecular focused on the future. We are not sure toxicology, expanding the definition of toxins to include what that future will look like, but we endogenously generated toxicants rather than just environmental can be sure that it will be dynamic, agents. In addition, the definition of toxicology has been extended challenging, and exciting. We can to include the study of how endogenous toxicants are involved in also be confident that with American the pathogenesis of disease. Chemical Society support, we will be sufficiently nimble to adapt to new In concert with the expanded scope, the journal has added the challenges and opportunities for the following new article types: benefit of our authors, readers, and sIn This Issue: short digests of articles in the journal. the toxicology community at large.” sSpotlights: highlights of articles in related journals. Lawrence J. Marnett, Editor, Chemical Research in Toxicology sGlobal Perspectives: preeminent researchers from around the Mary Geddes Stahlman Professor of Cancer world authoring guest editorials and sharing their views of the Research Professor of Biochemistry, Chemistry, and Pharmacology most important issues in toxicology within their own countries Director, Vanderbilt Institute of Chemical and as they relate to the global community.

Related Content Author Links

Highlights from the Current Issue Graphical Abstracts Spotlights

In This Issue

Related Section Links Journals

In addition, the new website offers enhanced navigation and tools such as: Editorial sGraphical Abstracts Perspectives sRelated Author Search Global sRelated Journals Perspectives sForward to a Friend Functionality

http://pubs.acs.org/CRT 02 EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1 ❂ !N)NTERVIEWWITH Accounts of Chemical Research%DITOR IN #HIEF*OAN36ALENTINE

fields, and to create a format that appeals to dialogue this internationalization creates a broad range of scientists wishing to keep not only enhances the journal but has led in on top of current research advances. many cases to wider international scientific At the time, it was a completely unique collaborations on the part of our readers. concept. You know that imitation is the sincerest form of flattery, and Joe has been Excellence: What special issues are planned flattered ever since as many journals have for Accounts in 2008? created “Perspectives” or other vehicles much like our Accounts. Neither Joe’s successor J.S.V.: We’ve started off the year with Fred McLafferty, nor I, have strayed from a special issue in January on Modern Joe’s original vision. Our readership relies on Molecular Approaches to Drug Design and Accounts for a concept that Joe created forty Discovery, with guest editor Iwao Ojima. years ago. The response has been excellent and we are looking forward to four more special issues Excellence: What major changes if any has this year on the topics of Peptidomimetics the journal experienced over the years? (or Peptide Mimics), Cross-Coupling Accounts of Chemical Research Reactions, Nanoscience, and Advanced Celebrates 40 Completed Volumes, Introduces Conspectus J.S.V.: Online publishing has probably Polymer Synthesis. brought about major changes to most Having completed its 40th volume of journals, certainly to our own in allowing us Excellence: The long list of distinguished published research in 2007 with its highest to publish articles online before the actual authors to Accounts over the past ISI® ever of 17.113 as issue in which they appear is printed. I 40 years reads like a veritable who’s reported in the 2006 Journal Citation think there has been a general trend toward who in chemistry; what contributors, Reports, Accounts of Chemical Research increasing the number of special issues we contributions, or experiences have stood presents short, concise and critical articles publish, each focusing on a topic of current out for you as Editor over the past 14 offering easy-to-read overviews of basic interest to the broad scientific community plus years? research and applications in all areas of and usually in response to the suggestions of chemistry and biochemistry. In recognition our editorial board. However, in my tenure J.S.V.: It’s been a wonderful—is it fourteen of those 40 years of published research and with Accounts, our major change has been years?! It seems like we’re just getting started. success, as well as recent changes in the the broadening of our focus to include a Each time I think I have an answer for this journal, we took some time to visit with wider scientific community abroad as well as question, I think of something else. Of Editor-in-Chief Joan S. Valentine. here in the . This has led us to course all of the contributions to the journal add distinguished foreign editorial advisory are significant, most notably those of the Excellence: Congratulations Dr. Valentine board members, reviewers and Consulting community of reviewers that have helped on the recent milestone for the journal, as Editors in both Asia and Europe, and it has establish and maintain the highest quality and well as the new design and the addition yielded a sizeable increase in contributions resonance for the research in the journal stand of the Conspectus features within the from leading scientists in Europe, Asia and out. I’ve had a chance to work with some journal. Some 40-plus years ago when the Latin America. I am glad to say that our brilliant people, but I would have to say that first issue was published, it was fair to call foreign readership has increased, along with none was more brilliant than Chris Foote, it a revolutionary idea at that time. How our contributor base and advisory board. my dear friend and colleague, and our late has that initial vision contributed to the Readers here in the United States have a Senior Editor, who was of so much help to longstanding success of the journal? greater opportunity to see what is happening me in finding my way at the beginning of my both inside and outside their own fields tenure on the journal, setting and keeping us Joan S. Valentine: First, congratulations internationally. Two years ago, we held to his own excellent standards right up until should really go to our founder, Joe Bunnett our first editorial advisory board meeting his death in 2005. All of us on the journal whose idea it was to create a journal offering outside of the United States in Budapest and never stop missing his wisdom and his wit. concise descriptions of recent research we are looking forward to another meeting developments in chemistry and related this year in Tianjin, China. I believe that the

03 EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1 as thinly as most of our colleagues, we well the research more widely understood and knew that often a glance at the abstract is as discoverable. What has been the reaction far as anyone gets in reading a review article. from the Accounts authorship at this early We wondered if our abstracts were somehow stage of implementation? missing an opportunity to draw the reader’s interest toward reading the complete J.S.V.: Authors never regret having a greater articles. We agreed that since our articles word limit within which to work, and the are meant to be read by a broad spectrum positioning of this in place of the abstract of researchers and not just specialists in affords them an opportunity to see their a particular field, we should try to find a story read by a wider audience. For the way to reach that non-specialist audience. most part, the reactions have been highly Soon we were kicking around the idea of positive about this chance to give a wider scrapping the usual 75-100 word abstract readership an insight into the heart of their in favor of something perhaps as long as article and offer a “take-home” message 400 words with a graphic or two that would even to those who do not read further. They give someone scanning it more of an idea of are delighted at the chance to elucidate this what lay in store in the actual article, a quick quick overview with graphic illustration, as Excellence: With the 1st issue in 2008, summary or a condensed version giving the well. We’re hoping the readers are as happy you introduced the Conspectus features reader more information than an abstract with the Conspectus as we are. in replacing the more standard article and a better idea of the significance of the abstracts in the journal; can you tell us research, therefore more reason to read on. Excellence: Let us again congratulate more about this new feature? A sort of über-abstract, we agreed, as we paid you on the recent milestone achievement our tab. A week or two later, in a flashing for the journal, the addition of the J.S.V.: One evening following our Advisory epiphany of near mystical significance, Conspectus features, and also thank you Board meeting in Chicago last year, my two Ken Houk discovered the perfect word for participating in this interview with the Senior Editors, Ken Houk (UCLA) and Paul for it: the Conspectus: “a general view or interest of keeping our audience well aware Barbara (U Austin) and I were having comprehensive survey (in the mind’s eye)” of the advancing developments for the a convivial (wine-fueled) post-mortem —(Oxford English Dictionary). Putting a journal and the ACS Publications program. discussing the new design of the journal name to an idea makes it real, and so, we planned to premiere with the January 2008 had arrived at the Conspectus, its goal, an Visit the Accounts 40th Anniversary website issue. Working with Amy Phifer, our graphic excellent scientific summary of each Account, http://pubs.acs.org/journals/achre4/ designer, we had redesigned the journal providing a more detailed description of promo/40th/index.html for more history cover and the inside layout and it seemed to the contents of the article, also thereby on the journal as well as the 40 most cited us that with the 41st volume, it might be a enhancing its discoverability by search articles and more, and visit the Accounts good time to make a major improvement in engines, encouraging still more readers Special Issues http://pubs.acs.org/journals/ substance as well as presentation. We were to undertake a thorough reading of the achre4/special.html page for listings, working on the second, or perhaps the third featured Account. descriptions, and TOC’s of all special issues. bottle of wine when we began to consider changes to the traditional abstract appearing Excellence: We are certainly excited here at the head of each article. As overextended at ACS Publications about this initiative research who spread ourselves and the opportunities it affords in making

Online publishing has probably brought about major changes to most“ journals, certainly to our own in allowing us to publish articles online before the actual issue in which they appear is printed.”

Joan S. Valentine Editor-in-Chief, Department of Chemistry and Biochemistry, UCLA

04 EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1 www.acsnanotation.org ❂ ACS Nano Indexed in ❂ Leading Scientific Databases ACS Nanotation is Live! Two common buzzwords in science today are “interdisciplinary” and “collaboration,” as the A measure of the rapid success lines between traditional disciplines are blurred and as scientific problems require a broader achieved by ACS Nano is its understanding and knowledge base. The field of is a great example of this since it indexing of all content to date by is at the interface of chemistry, physics, biology, engineering, and materials science. Nanoscience leading scientific databases such researchers have learned to speak one another’s language, to collaborate and find a common as SciFinder, , and ground. Google, to name a few. Ease of retrieving content ensures that Now, there is a home to support that common ground. Launched in October 2007, ACS your research gets the attention it Nanotation is packed with useful features designed to help nano researchers save time and effort: deserves. sResearch Highlights – across all ACS Publications, updated by the minute. ACS Nano continues to attract the sNano Picks – where selected experts review and provide insightful commentary on the most most important comprehensive recent and most important papers in the literature, encompassing topics that range from papers in nanoscience and scanning probe measurements of tumor cells to quantum dots in graphene to synthetic nanotechnology. It has recently molecular motors to nanowire-based sensors. Registered users have the opportunity to rate and featured articles by Jillian Buriak, comment on the reviewed papers. Moungi Bawendi, Naomi Halas, sAsk the Scientist – a forum to ask questions of a designated expert who Sumio Iijima, Arthur Nozik, is a leader in the field. Our current expert is Professor Paula Hammond, Thomas Russell, Vicki Colvin, Bayer Chair Professor of Chemical Engineering at MIT and Associate Editor Milan Mrksich, James Tour, and of ACS Nano. Professor Hammond’s interests are in the design, synthesis, Michael Strano. The content and directed assembly of macromolecules, and she is available to answer spans the breadth of the field, questions posed to her on this topic, and on the nanoscience field in general. from nanobio to nanoparticles to sNanoTube – the ACS Nanotation video gallery, allows registered users nanolithography. to upload and star in their own videos detailing their latest research or Paula Hammond, techniques that are commonly used in their labs. NanoTube is a great way for Associate Editor, You can learn more about the , Bayer Chair authors and researchers (especially those at the early stages of articles featured in ACS Nano Professor of Chemical their careers) to reach a new audience and promote their papers. Like all Engineering, MIT by reading each issue’s In Nano features on the site, you feature, summarizing the top are invited to contribute a video or comment on the existing content. research, or by listening sNano Wiki – contains a nano glossary as well as a list of key researchers in the field. to the monthly sImage Gallery – featuring an upcoming image contest. found on the website at sEvents Calendar – where users can submit their nano events. www.acsnano.org The site is updated regularly, so visit ACS Nanotation often, and contribute to the ever-growing nanoscience community.

05 EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1 ❂ #!33CIENCE3POTLIGHT-OST2EQUESTED!RTICLESIN#HEMISTRYAND2ELATED3CIENCE HTTPWWWCASORGSPOTLIGHTREQUESTHTML Chemical Abstracts Service (CAS), the world’s leader in providing chemical information, highlights the most requested documents using Real-Time Document Request (RDR) ranking. Tallying researchers’ actual requests (RDRs) for full-text articles via CAS online services establishes a new method of evaluating the actual use of scientific journals by scientists engaged in daily research. Aggregated data has been used to develop this ranking; activity of individual users is not tracked. CAS provides this information as a free service to the scientific community. Listed below are the chemistry and related science articles published in ACS Journals which researchers have most frequently requested while using CAS products during the fourth quarter of 2007 (SciFinder®, SciFinder Scholar, STN®, and CA on CD).

Hydrazines and Azides via the Metal-Catalyzed Hydrohydrazination and Hydroazidation of Olefins Waser, Jerome; Gaspar, Boris; et al. J. Am. Chem. Soc. American Chemical Society

Synthesis and in Vitro Antiprotozoal Activities of Dicationic 3,5- Diphenylisoxazoles Patrick, Donald A.; Bakunov, Stanislav A.; et al. J. Med. Chem. American Chemical Society

A .beta.-Keto Ester as a Novel, Efficient, and Versatile Ligand for Copper(I)-Catalyzed C-N, C-O, and C-S Coupling Reactions Lv, Xin; Bao, Weiliang J. Org. Chem. American Chemical Societ

Molecular Iodine-Catalyzed Facile Procedure for N-Boc protection of amines Varala, Ravi; Nuvula, Sreelatha; et al. J. Org. Chem. American Chemical Society

Highly Efficient Monophosphine-Based Catalyst for the Palladium Catalyzed Suzuki-Miyaura Reaction of Heteroaryl Halides and Heteroaryl Boronic Acids and Esters Billingsley, Kelvin; Buchwald, Stephen L. J. Am. Chem. Soc. American Chemical Society

Chiral Bronsted Acid Catalyzed Enantioselective Mannich-Type Reaction Yamanaka, Masahiro; Itoh, Junji; et al. J. Am. Chem. Soc. American Chemical Society

CAS is a team of scientists, creating and delivering the most complete and effective digital information environment for scientific research and discovery. CAS provides pathways to published research in the world’s journal and patent literature—virtually everything relevant to chemistry plus a wealth of information in the life sciences and a wide range of other scientific disciplines—back to the beginning of the late 19th century. CAS, a division of the American Chemical Society, provides the world’s largest and most current collection of chemical and related scientific information, including the most authoritative database of chemical substances, the CAS RegistrySM. CAS combines these databases with advanced search and analysis technologies to deliver the most complete, crosslinked, and effective digital information environment for scientific research and discovery, including such products as SciFinder®, SciFinder ScholarTM, STN®, STN Express®, and STN AnaVistTM, among others. See page 1 for information on CAS President Robert J. Massie receiving the Miles Conrad Award. 06 EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1

❂ !1UESTIONAND!NSWER3ESSIONWITH0ROFESSOR(ENRY2ZEPAˆ7HENCE7%/S

Web-Enhanced Objects (also known as WEOs) are components of articles which allow the communication of science in a way which is not possible in print. WEOs, however, are not as heavily used as they could be. At a very basic level, supplying certain types of data in a standard format can be the basis for a WEO, such as a CIF file for crystallographic data, a movie file for showing simulations of reactions, or a VRML file for presenting complex 3-D graphics. More information about these file formats can be found on the ACS website in the FAQ for WEOs.

One ACS author who makes heavy use of WEOs is Henry Rzepa of Imperial College, London. Rzepa is Professor of Chemistry, with research interests in chemistry and the , cheminformatics, and physical organic chemistry. He has published in a number of different ACS journals, and A Web enhanced object available in the Web version of the article showing with many other publishers as well. One of 3D coordinates for obusallenes V, VI, and VII his most recent articles containing WEOs is http://dx.doi.org/10.1021/np0705918. Professor Henry Rzepa LiveWire sat down with Professor Rzepa recently to discuss his use of WEOs and some of the more advanced methods he uses for creating WEOs.

Excellence: You have created far more WEOs than any other ACS author. What is your reason for creating these WEOs?

Prof. Rzepa: I started down this road almost 14 years ago! I was lucky enough to attend the very first World-Wide Web conference, where Tim Berners-Lee set out his vision of how the world would change. I decided that science would also need to change, and it was up to me When we decide to let the rest of the world know about it, we release and like-minded colleagues to help change the chemistry! it from its embargo and squirt it into the WEO (manually at the moment, but no doubt this could be semi-automated). This new set of Several such colleagues and I published our first article describing procedures has really revolutionized the way we work (we have recently our vision for this change in 1994 (http://dx.doi.org/10.1039/ submitted an article describing this project (SPECTRa) to JCIM). C39940001907 followed by the full article at DOI: http://dx.doi. org/10.1039/P29950000007), coining the term “hyperactive molecules.” Excellence: What type of information do you feel is most suitable for The emphasis even then was on how an interested reader (of, e.g., presentation as a WEO? a journal article) might be able to interact with and re-use the information in that article in the way that they felt benefited their Prof. Rzepa: At the moment my group concentrates on 3D molecular science. coordinates and properties of molecules, such as their electronic wavefunctions. But much more can and should be included. For The WEO is very much an implementation of those concepts. Indeed, example, spectroscopy is very amenable, albeit in refined form. For it’s actually at the heart of how we do our science. Each of our projects example, we do not envisage raw FIDs from NMR spectrometers as actually starts with a “WEO” (or you might call it an online, or being useful, but the Fourier transformed data would be useful. Peter electronic, notebook) which the students, collaborators, and I use to Murray-Rust, , has developed a system for develop the project. At the end, it’s organized into a cleaned up “WEO,” illustrating mechanistic arrow pushing (and lots more), Nick Greeves, and the article is sort of written around it. The reason we produce University of Liverpool, has used the wonderful program to so many WEOs is that they are simply a natural of how we do the same, and Eric Martz, University of Massachusetts, Amherst, organize the information coming from a project in the first place. In has created the exquisite Protein Explorer. I realize if I go on citing the last year or so, an additional component has been added to this everyone who deserves to be, this would take many more pages. practice, the institutional digital repository. The data, in our case Essentially, we need creative thinking, and creative and open software, coming from high performance computers, but also capable of coming to enable everyone to participate in their own particular interests. from x-ray diffractometers, NMR spectrometers, etc., is placed into a holding area and organized around our projects.

09 EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1 Excellence: How much time does it take you to create a WEO for an ❂ 3POTLIGHTON*MOLAN/PEN3OURCE3OFTWARE article? What steps do you take in creating a WEO? !PPLICATIONFOR$ISPLAYINGAND)NTERACTINGWITH  DIMENSIONAL2EPRESENTATIONSOF#HEMICAL Prof. Rzepa: I have answered that in part above. Clearly, at the moment it helps to be fluent in HTML, but in fact, templates and some degree 3TRUCTURES of automation will probably help in the future. The WEOs evolved for us because we have access to high-quality data appropriate for their The Jmol program, first released in the late 1990s, was written by use, and hence it does not take much time for us to produce them. We Dan Gezelter as a replacement for the XMol molecular viewing have developed our own templates over the last few years, so loading program developed at the Minnesota Supercomputer Center. data into them from our institutional data repository is now pretty Version 11.4 was released in early 2008 with the development effort straightforward. All that data is in XML; more specifically CML, which for the program done on SourceForge, the major environment Peter Murray-Rust and I started in 1995, realizing it would be an for open source software development at http://jmol.sourceforge. essential part of this new Web-based environment. Over the years, it has net/history/. Over the years, a number of different developers have become capable of handling more and more chemistry (http://dx.doi. made significant contributions to the application as indicated by org/10.1021/ci600531a). We coined the term “datument” for any article the list of 32 developers currently listed on the the SourceForge that is both data rich and a document as well. In that sense, a WEO website. Bob Hanson of Saint Olaf College is currently the project is merely a half way house to the future. The WEO carries data, and a leader for the Jmol development team. mechanism for displaying it. But in the future, the distinction between a WEO and the rest of the scientific article will vanish. The WEO, or The earliest version of Jmol could display structures from a single datument, call it what you wish, WILL BE the article! file format, XYZ. Since that time, enhancements have been made to support a wide variety of file formats, a number of different Excellence: One of the tools you use regularly to display your WEOs views of a structure, as well as capabilities for animation and is Jmol. What are some of the capabilities of Jmol which you find interactivity. One of the interesting new features allows one to useful? specify a path to be followed to traverse through a structure. From a defined starting point, one travels through the molecule, Prof. Rzepa: Well, it’s evolving all the time, and a very active community, viewing the various bonds and atoms from the perspective inside drawn from many areas of science, is driving its capabilities constantly. the molecule. This is in contrast to the usual perspective offered by We use its ability to display 3D coordinates, and to interact with viewing applications, in which one sees the molecule rotating from those coordinates in interesting ways. One can script much activity the perspective outside the structure. to illustrate a scientific point. It now displays far more complex large (bio)(macro)molecules in many new styles, and ways of interacting. Most In addition to its utility as a structure viewing application, Jmol is importantly, it’s open, and it’s developed openly by a highly enthusiastic also widely used as a teaching tool. The Jmol wiki contains community. Bob Hanson, who currently might be described as the chief contributions from faculty members at a number of different editor of this activity, absolutely deserves a mention here, but Jmol has schools demonstrating ways in which they have incorporated Jmol been, and continues to be, developed through the efforts associated into their curriculum. The Jmol wiki also contains documentation with an open community. Its impact continues to grow as a tool to on the application, and a set of tutorials contributed by Jmol users communicate chemistry in a digital environment. to help you get started. In the simplest form, supplying a structure in one of the supported formats (including both pdb and cif) can Excellence: Do you create your WEOs yourself, or do you give that be the basis for a Web-Enhanced Object using Jmol. assignment to your younger students and/or colleagues? The Jmol application is available from http://jmol.sf.net. Prof. Rzepa: I train new graduate students to create the progenitors of WEOs as part of their starting experience. They do seem to love it! Of course, that is just our interpretation of a WEO. When something is new, you have in part to make the rules up yourself. Others may have quite a different idea of what a WEO is. That is the excitement of it; each discipline has to decide for itself what a WEO might mean for it, and to experiment with new forms!

Excellence: What advice would you give to authors who want to try WEOs out? Where can one find out how to create WEOs?

Prof. Rzepa: A good place to start investigating what a WEO might do for you is to visit the Jmol site and to look at some of the examples there. Few could leave that site without being inspired by the possibilities. 6IEWA$-OLECULAR-ODELIN*-OLOF()6 2EVERSE4RANSCRIPTASE3TRUCTUREWITH Excellence: Thanks for your comments, and keep those WEOs coming. 2.ASE()NHIBITOR$IHYDROXY"ENZOYL.APHTHYL(YDRAZONE"OUNDATA.OVEL3ITE For our readers, a page has been created on pubs.acs.org with links to a Himmel D. M.; Sarafianos S. G.; Dharmasena S. ; Hossain M. M.; McCoy-Simandle K. ; Ilina T. ; Clark A. D.; Knight J. L.; Julias J. G.; Clark P. K.; Krogh- selection of articles containing a variety of WEOs. Check out the WEOs Jespersen K. ; Levy R. M.; Hughes S. H.; Parniak M. A.; Arnold E. and think of the possibilities for your own publications. ACS Chemical Biology; (Article); 2006; 1(11); 702-712. DOI: 10.1021/cb600303y

10 EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1 THE ❂ Biochemistry Crystal Growth & Design MOST Applications of Phospholipid Bilayer Molecules to Crystals, Crystals to Molecules... Nanodiscs in the Study of Membranes and and Back Again? ACS Publications provides listings online of the Membrane Proteins Zaworotko, M. J. most highly ranked research articles published Nath, A.; Atkins, W. M.; Sligar, S. G. Cryst. Growth Des.; (Perspective); 2007; in ACS Journals in four categories, updated on Biochemistry; (Current Topics/Perspectives); 7(1); 4-9. DOI: 10.1021/cg0680172 a regular basis. Most-Cited Articles are based 2007; 46(8); 2059-2069. on data from the Thomson Scientific Web of DOI: 10.1021/bi602371n Energy & Fuels Science®. Most-Accessed Articles are based Desorption and Ionization of Heavy on article web view data collected following Bioconjugate Chemistry Petroleum Molecules and Measurement of COUNTER-compliant ACS Usage Reports. Stability of Cell-Penetrating Peptide- Molecular Weight Distributions Rankings of Highly Cited Articles and Hot Morpholino Oligomer Conjugates in Human Qian, K.; Edwards, K. E.; Siskin, M.; Papers are based on data from the Thomson Serum and in Cells Olmstead, W. N.; Mennito, A. S.; Dechert, Scientific Essential Science Indicators®. Article Youngblood, D. S.; Hatlevig, S. A.; Hassinger, J. G. J.; Hoosain, N. E. listings are updated frequently throughout N.; Iversen, P. L.; Moulton, H. M. Energy & Fuels; (Article); 2007; 21(2); the year, with quarterly and annual rankings Bioconjugate Chem.; (Article); 2007; 1042-1047. DOI: 10.1021/ef060360t available for the most cited and most accessed 18(1); 50-60. DOI: 10.1021/bc060138s articles, and Highly Cited Articles and Hot Environmental Science & Technology Papers updated per the Essential Science Biomacromolecules Evidence for Organosulfates in Secondary Indicators. Synthesis of Temperature-Responsive Organic Aerosol Heterobifunctional Block Copolymers Surratt, J. D.; Kroll, J. H.; Kleindienst, T. E.; Featured here are the #1 most cited articles of Poly(ethylene glycol) and Poly(N - Edney, E. O.; Claeys, M.; Sorooshian, A.; Ng, N. published in 2007 from every ACS Journal as of isopropylacrylamide) L.; Offenberg, J. H.; Lewandowski, M.; Jaoui, December 31, 2007: You, Y.-Z.; Oupicky, D. M.; Flagan, R. C.; Seinfeld, J. H. Biomacromolecules; (Article); 2007; 8(1); Environ. Sci. Technol.; (Article); 2007; 41(2); Accounts of Chemical Research 98-105. DOI: 10.1021/bm060635b 517-527. DOI: 10.1021/es062081q Plasmonic Nanostructures: Artificial Molecules Biotechnology Progress Industrial & Engineering Chemistry Research Wang, H.; Brandl, D. W.; Nordlander, P.; Evaluating the Distribution of Cellulases and Stabilization of Fe-Pd Nanoparticles with Halas, N. J. the Recycling of Free Cellulases during the Sodium Carboxymethyl Cellulose for Acc. Chem. Res.; (Article); 2007; 40(1); 53-62. Hydrolysis of Lignocellulosic Substrates Enhanced Transport and Dechlorination of DOI: 10.1021/ar0401045 Tu, M.; Chandra, R. P.; Saddler, J. N. Trichloroethylene in Soil and Groundwater Biotechnol. Prog.; (Article); 2007; 23(2); He, F.; Zhao, D.; Liu, J.; Roberts, C. B. ACS Chemical Biology 398-406. DOI: 10.1021/bp060354f Ind. Eng. Chem. Res.; (Article); 2007; 46(1); 29- Achieving In-Depth Proteomics Profiling by 34. DOI: 10.1021/ie0610896 Mass Spectrometry Chemical Research in Toxicology Ahn N. G.; Shabb J. B.; Old W. M.; Resing K. A. Electrophilic Chemistry Related to Skin Inorganic Chemistry ACS Chem. Biol.; (Review); 2007; 2(1); 39-52. Sensitization. Reaction Mechanistic Binuclear Iron-Sulfur Complexes with DOI: 10.1021/cb600357d Applicability Domain Classification for a Bidentate Phosphine Ligands as Active Published Data Set of 106 Chemicals Tested in Site Models of Fe-Hydrogenase and Their ACS Nano the Mouse Local Lymph Node Assay Catalytic Proton Reduction Molecular Self-Assembly at Bare Roberts, D. W.; Aptula, A. O.; Patlewicz, G. Gao, W.; Ekstrom, J.; Liu, J.; Chen, C.; Eriksson, Semiconductor Surfaces: Characterization Chem. Res. Toxicol.; (Article); 2007; 20(1); L.; Weng, L.; Akermark, B.; Sun, L. of a Homologous Series of n-Alkanethiolate 44-60. DOI: 10.1021/tx060121y Inorg. Chem.; (Article); 2007; 46(6); 1981-1991. Monolayers on GaAs(001) DOI: 10.1021/ic0610278 McGuiness C. L.; Blasini D.; Masejewski J. P.; Chemical Reviews Uppili S.; Cabarcos O. M.; Smilgies D.; Aryl-Aryl Bond Formation by Transition- Journal of Agricultural and Food Chemistry Allara D. L. Metal-Catalyzed Direct Arylation Impact of Electrostatic Interactions on ACS Nano; (Article); 2007; 1(1); 30-49. Alberico, D.; Scott, M. E.; Lautens, M. Formation and Stability of Emulsions Chem. Rev.; (Review); 2007; 107(1); 174-238. Containing Oil Droplets Coated by Analytical Chemistry DOI: 10.1021/cr0509760 b-Lactoglobulin-Pectin Complexes Supplemental Activation Method for High- Guzey, D.; McClements, D. J. Efficiency -Transfer Dissociation of Chemistry of Materials J. Agric. Food Chem.; (Article); 2007; 55(2); Doubly Protonated Peptide Precursors Controlled Synthesis and Luminescence of 475-485. DOI: 10.1021/jf062342f Swaney, D. L.; McAlister, G. C.; Wirtala, M.; Lanthanide Doped NaYF4 Nanocrystals Schwartz, J. C.; Syka, J. E. P.; Coon, J. J. Wang, L.; Li, Y. Anal. Chem.; (Article); 2007; 79(2); 477-485. Chem. Mater.; (Article); 2007; 19(4); 727-734. DOI: 10.1021/ac061457f DOI: 10.1021/cm061887m

11 EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1 Journal of the American Chemical Society The Journal of Organic Chemistry Molecular Pharmaceutics Enantioselective Friedel-Crafts Reaction of Supramolecular Analytical Chemistry Molecular Engineering of Dendritic Polymers Electron-Rich Alkenes Catalyzed by Chiral Anslyn, E. V. and Their Application as Drug and Gene Brønsted Acid J. Org. Chem.; (Perspective); 2007; 72(3); Delivery Systems Terada, M.; Sorimachi, K. 687-699. DOI: 10.1021/jo0617971 Paleos, C. M.; Tsiourvas, D.; Sideratou, Z. J. Am. Chem. Soc.; (Communication); 2007; Molecular Pharmaceutics; (Review); 2007; 129(2); 292-293. DOI: 10.1021/ja0678166 The Journal of Physical Chemistry A 4(2); 169-188. DOI: 10.1021/mp060076n Rapid and Accurate Estimation of Densities of Journal of Chemical & Engineering Data Room-Temperature Ionic Liquids and Salts Nano Letters High-Pressure Densities and Derived Ye, C.; Shreeve, J. M. Enhanced Charge-Collection Efficiencies and Thermodynamic Properties of Imidazolium- J. Phys. Chem. A.; (Article); 2007; 111(8); Light Scattering in Dye-Sensitized Solar Cells Based Ionic Liquids 1456-1461. DOI: 10.1021/jp066202k Using Oriented TiO2 Nanotubes Arrays Gardas, R. L.; Freire, M. G.; Carvalho, P. J.; Zhu, K.; Neale, N. R.; Miedaner, A.; Frank, A. J. Marrucho, I. M.; Fonseca, I. M. A.; Ferreira, A. The Journal of Physical Chemistry B Nano Lett.; (Letter); 2007; 7(1); 69-74. G. M.; Coutinho, J. A. P. Segregation in Room Temperature DOI: 10.1021/nl062000o J. Chem. Eng. Data; (Article); 2007; 52(1); Ionic Liquids 80-88. DOI: 10.1021/je060247x Triolo, A.; Russina, O.; Bleif, H.-J.; Di Cola, E. Organic Letters J. Phys. Chem. B.; (Article); 2007; 111(18); Reaction Solvent Selection: The Potential Journal of Chemical Information 4641-4644. DOI: 10.1021/jp067705t of Water as a Solvent for Organic and Modeling Transformations Accurate Solubility Prediction with Error The Journal of Physical Chemistry C Hailes, H. C. Bars for Electrolytes: A Machine Learning Meeting the Clean Energy Demand: Org. Process Res. Dev.; (Review); 2007; 11(1); Approach Nanostructure Architectures for Solar 114-120. DOI: 10.1021/op060157x Schwaighofer, A.; Schroeter, T.; Mika, S.; Laub, Energy Conversion J.; ter Laak, A.; Sulzle, D.; Ganzer, U.; Heinrich, Kamat, P. V. Organic Process Research & Development N.; Muller, K.-R. J. Phys. Chem. C.; (Feature Article); 2007; Rhodamine-Based Hg2+-Selective J. Chem. Inf. Model; (Article); 2007; 47(2); 111(7); 2834-2860. DOI: 10.1021/jp066952u Chemodosimeter in Aqueous Solution: 407-424. DOI: 10.1021/ci600205g Fluorescent OFF-ON Journal of Proteome Research Wu, J.-S.; Hwang, I.-C.; Kim, K. S.; Kim, J. S. Journal of Chemical Theory and Computation Head-to-Head Comparison of Serum Org. Lett.; (Letter); 2007; 9(5); 907-910. DOI: Critical Assessment of the Performance of Fractionation Techniques 10.1021/ol070109c Density Functional Methods for Several Whiteaker, J. R.; Zhang, H.; Eng, J. K.; Fang, R.; Atomic and Molecular Properties Piening, B. D.; Feng, L.-C.; Lorentzen, T. D.; Organometallics Riley, K. E.; Op’t Holt, B. T.; Merz, K. M., Jr. Schoenherr, R. M.; Keane, J. F.; Holzman, T.; Insertion of a N-Heterocyclic Carbene (NHC) J. Chem. Theory and Comput.; (Article); 2007; Fitzgibbon, M.; Lin, C. W.; Zhang, H.; Cooke, into a Platinum-Olefin Bond 3(2); 407-433. DOI: 10.1021/ct600185a K.; Liu, T.; Camp, D. G., II; Anderson, L.; Fantasia, S.; Jacobsen, H.; Cavallo, L.; Watts, J.; Smith, R. D.; McIntosh, M. W.; Nolan, S. P. Journal of Combinatorial Chemistry Paulovich, A. G. Organometallics; (Communication); 2007; Solution-Phase Parallel Synthesis of J. Proteome Res.; (Article); 2007; 6(2); 828-836. 26(14); 3286-3288. DOI: 10.1021/om700447u 3,5,6-Substituted Indolin-2-ones DOI: 10.1021/pr0604920 Yang, T.-M.; Liu, G. J. Comb. Chem.; (Article); 2007; 9(1); 86-95. Langmuir DOI: 10.1021/cc060124t How Wenzel and Cassie Were Wrong Gao, L.; McCarthy, T. J. Journal of Medicinal Chemistry Langmuir; (Research Article); 2007; 23(7); Isofagomine- and 2,5-Anhydro-2,5-imino- 3762-3765. DOI: 10.1021/la062634a D-glucitol-Based Glucocerebrosidase Pharmacological Chaperones for Gaucher Macromolecules Disease Intervention Versatile Pathway to Functional Telechelics Yu, Z.; Sawkar, A. R.; Whalen, L. J.; Wong, via RAFT Polymerization and Click C.-H.; Kelly, J. W. Chemistry J. Med. Chem.; (Brief Article); 2007; 50(1); Gondi, S. R.; Vogt, A. P.; Sumerlin, B. S. 94-100. DOI: 10.1021/jm060677i Macromolecules; (Article); 2007; 40(3); 474-481. DOI: 10.1021/ma061959v Journal of Natural Products Natural Products as Sources of New Drugs over the Last 25 Years To view more of “The Most,” go to Newman, D. J.; Cragg, G. M. http://pubs.acs.org/acs/themost J. Nat. Prod.; (Review); 2007; 70(3); 461-477. DOI: 10.1021/np068054v

12 EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1 ❂ 4HE!#3.ATIONAL!WARDS0ROGRAM2ECOGNIZING0REMIER#HEMICAL0ROFESSIONALSIN%XTRAORDINARY7AYS

With every award recipient serving as a reminder Selected 2008 ACS National Awards and Award for Volunteer Service to the American of the positive impact a single individual can Respective Award Recipients: Chemical Society sponsored by the American make, and of the great influence chemistry has on Chemical Society; Thomas L. Netzel, Georgia ACS Award for Achievement in Research for the the world around us, the ACS National Awards State University. Address to be presented at the Teaching & Learning of Chemistry ChemLuminary Awards in Philadelphia. program recognizes many diverse fields. sponsored by Pearson Education; Dorothy L. Gabel, Indiana University. Address to be presented ACS Award in Analytical Chemistry Award recipients traditionally receive their before the Division of Chemical Education. sponsored by Battelle Memorial Institute; Robert national award in person during the ACS awards M. Wightman, University of North Carolina, ACS Award for Computers in Chemical & dinner and general meeting held every Spring Chapel Hill. Address to be presented before the Pharmaceutical Research sponsored by Division of Analytical Chemistry in Philadelphia. at the ACS National Meeting, and then deliver Schrödinger; James A. McCammon, University an award address on the scientific work that is of California, San Diego. Address to be presented ACS Award in Applied Polymer Science being recognized to an appropriate division. The before the Division of Computers in Chemistry. sponsored by Eastman Chemical Co.; P. Anne Spring 2008 event is being held on the evening Hiltner, Case Western Reserve University. Address ACS Award for Creative Advances in of Tuesday, April, 8, at The Sugar Mill in New to be presented before the Division of Polymeric Environmental Science & Technology Materials: Science & Engineering. Orleans, Louisiana. Dinner begins at 7:30 PM and sponsored by Air Products & Chemicals Inc., in the general meeting begins at 8:30. memory of Joseph J. Breen; Susan D. Richardson, ACS Award in Chromatography recipient Gabor Somorjai will deliver the Priestley U.S. Environmental Protection Agency-National sponsored by Supelco Inc.; Frantisek Svec, Medal Address at the general meeting while Exposure Research Laboratory. Address to be University of California, Berkeley. Address to several additional awards including the Arthur presented before the Division of Environmental be presented before the Division of Analytical C. Cope Scholar Awards and the Arthur C. Cope & Analytical Science. Chemistry in Philadelphia. Award address will be presented at the 236th ACS ACS Award for Creative Invention ACS Award in Colloid & Surface Chemistry National Meeting in Philadelphia this August. (See sponsored by ACS Corporation Associates; sponsored by Procter & Gamble Co.; Lee R. page 19 for more on Dr. Somorjai). Adam Heller, University of Texas. Address to White, Carnegie Mellon University. Address to be be presented before the Division of Analytical presented before the Division of Colloid & Surface Forms for nominations and supporting Chemistry in Philadelphia. Chemistry. information with a detailed description of ACS ACS Award for Creative Work in Fluorine ACS Award in Industrial Chemistry National Awards, and past awardees, are available Chemistry sponsored by SynQuest Laboratories sponsored by ACS Division of Business at http://www.acs.org/awards. The deadline Inc. and Honeywell; Dennis P. Curran, University Development & Management and the Synthetic date for all nominating material for 2009 ACS of Pittsburgh. Address to be presented before the Organic Chemical Manufacturers Association; Awards is November 1, 2008. Earlier transmittal is Division of Fluorine Chemistry. Timothy J. Wallington, Ford Motor Co. Address encouraged. For more information about the ACS to be presented before the Division of Business ACS Award for Creative Work in Synthetic Development & Management. Awards Program, please visit the website above, Organic Chemistry sponsored by Aldrich call the Awards Office at 202-872-4408, or send Chemical Co. Inc.; Masakatsu Shibasaki, ACS Award in Inorganic Chemistry them an email at [email protected] . University of . Address to be presented sponsored by Aldrich Chemical Co. Inc.; Kenneth before the Division of Organic Chemistry. N. Raymond, University of California, Berkeley. Address to be presented before the Division of ACS Award for Distinguished Service in the Inorganic Chemistry. Advancement of Inorganic Chemistry sponsored by Strem Chemicals Inc.; Tobin J. ACS Award in Marks, . (Dr. Marks is sponsored by Dow Chemical Co. Foundation; an Associate Editor for Organometallics). Address Gerard F. R. Parkin, . to be presented before the Division of Inorganic Address to be presented before the Division of Chemistry. Inorganic Chemistry. ACS Award for Encouraging Disadvantaged ACS Award in Polymer Chemistry Students into Careers in the Chemical Sciences sponsored by ExxonMobil Chemical Co.; James sponsored by the Camille & Henry Dreyfus E. McGrath, Virginia Polytechnic Institute & State Foundation Inc.; Susan V. Olesik, Ohio State University. Address to be presented before the University. Address to be presented before the Division of Polymer Chemistry. Division of Analytical Chemistry in Philadelphia. ACS Award in Pure Chemistry ACS Award for Encouraging Women into Careers sponsored by Alpha Chi Sigma Fraternity and the in the Chemical Sciences sponsored by the Alpha Chi Sigma Educational Foundation; Camille & Henry Dreyfus Foundation Inc.; Esther Rustem F. Ismagilov, University of Chicago. M. Conwell, University of Rochester. Address Address to be presented before the Division of to be presented before the Women Organic Chemistry. Committee. Photo by Peter Cutts: LtoR Thomas E. Lane, ACS ACS Award in the Chemistry of Materials President-Elect; Bruce Ganem, 2007 Recipient of the ACS Award for Research at an Undergraduate sponsored by E. I. du Pont de Nemours & Co.; ACS Award for Creative Invention; Catherine T. Hunt Institution sponsored by Research Corporation; Thomas E. Mallouk, (Dr. Mallouk is an Associate ACS Immediate Past President. Dr. Ganem is also the John T. Gupton, University of Richmond. Address Editor for The Journal of the American Chemical corresponding author on the article / cover art to be presented before the Division of Organic Society). Pennsylvania State University. Address featured on this issue of the (see page 1). Chemistry. to be presented before the Division of Inorganic Chemistry. ACS Award for Team Innovation Sponsored by ACS Corporation Associates; Stanley ACS Award in Separations Science & Technology B. Collins and Scott R. Culler, 3M Corp. Address sponsored by Waters Corp.; Allan S. Myerson, (Dr. to be presented before the Division of Industrial & Myerson is an Associate Editor for Crystal Growth Engineering Chemistry. & Design) Illinois Institute of Technology. Address to be presented before the Division of Industrial & 13 Engineering Chemistry. EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1 ACS Award in Theoretical Chemistry Elias J. Corey Award for Outstanding Original E. V. Murphree Award in Industrial & Engineering sponsored by IBM Corp.; William A. Goddard Contribution in Organic Synthesis by a Young Chemistry sponsored by ExxonMobil Research III, California Institute of Technology. Address Investigator sponsored by the Pfizer Endowment & Engineering Co.; Georges Belfort, Rensselaer to be presented before the Division of Physical Fund; F. Dean Toste, University of California, Polytechnic Institute. Address to be presented Chemistry. Berkeley. Address to be presented before the before the Division of Industrial & Engineering Division of Organic Chemistry. Chemistry in Philadelphia. Arthur W. Adamson Award for Distinguished Service in the Advancement of Surface Chemistry F. Albert Cotton Award in Synthetic Inorganic Nobel Laureate Signature Award for Graduate sponsored by the American Chemical Society; Chemistry sponsored by the F. Albert Cotton sponsored by Francisco Zaera, University of California, Riverside Endowment Fund; John D. Corbett, Iowa State Mallinckrodt Baker Inc.; David S. Eisenberg (Dr. Zaera is a Senior Editor for the Journal of University. Address to be presented before the (preceptor), University of California, Los Angeles; Physical Chemistry). Address to be presented before Division of Inorganic Chemistry. Rebecca Anne Nelson, Howard Hughes Medical the Division of Colloid & Surface Chemistry. Institute, UCLA. Address to be presented before the Award in Physical Chemistry Division of Biological Chemistry. Alfred Bader Award in Bioinorganic or sponsored by E. I. du Pont de Nemours & Co.; sponsored by Alfred R. Michael L. Klein, University of Pennsylvania. Award in Physical Organic Bader; Lawrence Que Jr., University of Minnesota. Address to be presented before the Division of Chemistry sponsored by the ACS Northeastern Address to be presented before the Division of Physical Chemistry. Section; Dennis A. Dougherty, California Institute Inorganic Chemistry. of Technology. Address to be presented before the Frank H. Field & Joe L. Franklin Award for Division of Organic Chemistry. Ronald Breslow Award for Achievement in Outstanding Achievement in Mass Spectrometry Biomimetic Chemistry sponsored by Ronald sponsored by Waters Corp.; Catherine C. Fenselau, George A. Olah Award in Hydrocarbon or Breslow Endowment; Joanna Aizenberg, of Maryland (Dr. Fenselau is an Petroleum Chemistry sponsored by George A. University. Address to be presented before the Associate Editor for Analytical Chemistry). Address Olah Endowment Fund; Israel E. Wachs, Lehigh Division of Organic Chemistry & Chemistry of to be presented before the Division of Analytical University. Address to be presented before the Materials. Chemistry in Philadelphia. Division of Petroleum Chemistry.

Herbert C. Brown Award for Creative Research in Francis P. Garvan-John M. Olin Medal George C. Pimentel Award in Chemical Education Synthetic Methods sponsored by Purdue Borane sponsored by the Francis P. Garvan-John M. Olin sponsored by Rohm and Haas Co.; Richard N. Zare, Research Fund and the Herbert C. Brown Award Medal Endowment; Elizabeth C. Theil, Children’s . Address to be presented before Endowment; Eric N. Jacobsen, Harvard University. Hospital Oakland Research Institute. Address to the Division of Chemical Education. Address to be presented before the Division of be presented before the Division of Inorganic Organic Chemistry. Chemistry. Priestley Medal sponsored by the American Chemical Society; Gabor A. Somorjai, University of James Bryant Conant Award in High School James T. Grady-James H. Stack Award for California, Berkeley. Address to be presented before Chemistry Teaching sponsored by Thermo Fisher Interpreting Chemistry for the Public the general meeting of the American Chemical Scientific Inc.; Richard Goodman, Horace Greeley sponsored by the American Chemical Society; Society on Tuesday, April 8, at The Sugar Mill, and High School. Address to be presented before the Harold McGee, Curious Cook. Address to be the Division of Colloid & Surface Chemistry. (See Division of Chemical Education. presented before the Division of Agricultural & page 19 for more on Dr. Somorjai). Food Chemistry. Alfred Burger Award in Medicinal Chemistry Glenn T. Seaborg Award for Nuclear Chemistry sponsored by GlaxoSmithKline; Magid Abou- Ernest Guenther Award in the Chemistry of sponsored by the ACS Division of Nuclear Gharbia, Wyeth Research. Address to be presented Natural Products sponsored by Givaudan; David Chemistry & Technology; Romualdo T. de Souza, before the Division of Medicinal Chemistry. G. I. Kingston, Virginia Polytechnic Institute & Indiana University. Address to be presented before State University. Address to be presented before the the Division of Nuclear Chemistry & Technology. Arthur C. Cope Award sponsored by the Arthur Division of Organic Chemistry. C. Cope Fund; James F. Stoddart, University of Gabor A. Somorjai Award for Creative Research California, Los Angeles. Address to be presented Award in the Theoretical in sponsored by the Gabor A. & Judith K. before the Division of Organic Chemistry in & Experimental Chemistry of Liquids sponsored Somorjai Endowment Fund; , Philadelphia. by ExxonMobil Research & Engineering Co.; Pablo Instituto de Technologia Quimica, UPV-CSIC. G. Debenedetti, Princeton University. Address Address to be presented before the Catalysis & Arthur C. Cope Scholar Awards sponsored by the to be presented before the Division of Physical Surface Science Secretariat. (See page 19 for more Arthur C. Cope Fund; Jeffrey W. Bode, University Chemistry. on Dr. Somorjai). of California, Santa Barbara; Cynthia J. Burrows, University of Utah (Dr. Burrows is the Senior Ralph F. Hirschmann Award in Peptide Chemistry E. Bright Wilson Award in Spectroscopy Editor for The Journal of Organic Chemistry); sponsored by Merck Research Laboratories; sponsored by the American Chemical Society; Dieter Enders, RWTH Aachen University, Institute William F. DeGrado, University of Pennsylvania. Jack H. Freed, . Address to Fuer Organische Chemie.; Tamio Hayashi, Kyoto Address to be presented before the Division of be presented before the Division of Physical University; Linda C. Hsieh-Wilson, California Organic Chemistry. Chemistry. Institute of Technology; Colin P. Nuckolls, Columbia University; Melanie S. Sanford, Frederic Stanley Kipping Award in Silicon Ahmed Zewail Award in Ultrafast Science & University of Michigan; Thomas S. Scanlan, Chemistry sponsored by Dow Corning Corp.; Technology sponsored by the Ahmed Zewail Oregon Health & Science University; Mukund P. T. Don Tilley, University of California, Berkeley. Endowment Fund established by Newport Corp.; Sibi, North Dakota State University; and Daniel A. Address to be presented before the Division of Graham R. Fleming, University of California, Singleton, Texas A&M University (Dr. Singleton Inorganic Chemistry. Berkeley. Address to be presented before the is an Associate Editor for The Journal of Organic Division of Physical Chemistry. Chemistry). Address to be presented before the Award in Chemical Physics Division of Organic Chemistry at the 236th ACS sponsored by General Electric Global Research; National Fresenius Award sponsored by Phi national meeting in Philadelphia in August. Daniel M. Neumark, University of California, Lambda Upsilon, the national honorary chemical Berkeley. Address to be presented before the society; Daniel T. Chiu, University of Washington. Division of Physical Chemistry. Address to be presented before the Division of Analytical Chemistry in Philadelphia.

14 EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1 ❂ The Online Cycle of Excellence Our commitment to excellence in the ACS publishing and peer-review process also extends to excellence on the web, providing the international community of researchers, authors, editors, and reviewers with the online resources to support them in their efforts to advance the field of chemistry and related sciences.

ACS AuthorChoice *OURNALINTHE.EWS Chemical & Engineering News Want your article to have unrestricted web ACS Journals are routinely featured in Weekly news magazine published by access? Find out how. news stories in the general media. the American Chemical Society. HTTPPUBSACSORGACSAUTHORCHOICE HTTPPUBSACSORGACSINTHENEWS HTTPPUBSACSORGCEN !UTHOR2EVIEWER2ESOURCE#ENTER “The Most” 233&EEDS Central resource center for the ACS The MOST-cited, MOST-accessed, hot papers, Stay up to date with newly posted Publications author and reviewer community. and highly-cited research from ACS journals. content on your desktop. HTTPPUBSACSORGAUTHORS HTTPPUBSACSORGACSTHEMOST HTTPPUBSACSORGALERTSRSS !#3!RTICLESON2EQUEST ASAP Alerting Service ACS Legacy Archives Share 50 free re-prints of your published Receive daily or weekly e-mails when new All titles, volumes, issues, and articles article with colleagues. individual articles are released on the web. published by the ACS from 1879 to 1995. HTTPPUBSACSORGACSREPRINTS HTTPPUBSACSORGALERTSASAP HTTPPUBSACSORGARCHIVES Citation Manager Functionality Table of Contents (TOC) Alerting Service %XCELLENCE.EWSLETTER Learn how to download and save citations Receive e-mail alerts of the Table of Contents Interviews, community features, news from our highly cited journals. for an issue as soon as it’s posted online. and articles on topics of interest to HTTPPUBSACSORGJOURNALSCITATION HTTPPUBSACSORGALERTSTOC authors and reviewers. HTTPPUBSACSORGACSEXCELLENCE ACS Paragon Plus Environment Ethical Guidelines for ACS Journals Streamline manuscript submission Guidelines for publication of research for service for authors and reviewers. Editors, authors and manuscript reviewers. Submit your paper today. HTTPPUBSACSORGETHICS HTTPPUBSACSORGPARAGONPLUS

❂ Bionconjugate Chemistryˆ.OW0UBLISHING-ONTHLY

As a reflection of growth in the field, and the vision of the journal upon its launch in 1990, the breadth of published research in Bioconjugate Chemistry has grown significantly over the past 18 years. Now publishing monthly, the journal invites Topics of current interest include molecules that influence cellular original contributions on all aspects of the uptake and trafficking and also those attached to particles or surfaces. joining of different molecular functions by Bioconjugate Chemistry is the international forum for the presentation chemical or biological means. This includes of research relevant to all aspects of conjugation chemistry and the conjugation of antibodies, nucleic acids, biochemistry, including the preparation, characterization, and lipids, carbohydrates, or other biologically properties (both chemical and biological) of molecular conjugates. active molecules and their analogs with The journal emphasizes rigorous chemical standards and encourages any molecular groups that add useful properties, such as drugs, application of modern techniques of chemical analysis to problems in radionuclides, toxins, fluorophores, photoprobes, inhibitors, enzymes, conjugation chemistry. haptens, ligands, and more.

15 EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1 ❂ JOC)NTRODUCES&EATURED!RTICLESAND7ELCOMES ❂ Biochemistry Introduces Rapid Reports its First International Associate Editor “It is with great excitement that we Beginning in 2008, The Journal of Organic Chemistry now introduce Biochemistry Rapid Reports. publishes JOC Featured Articles. These are full papers selected by This new expedited manuscript type Editor-in-Chief C. Dale Poulter and the JOC Associate Editors for provides you with the opportunity special consideration based on importance, novelty, and quality. to present fast breaking, innovative research to the world-wide community Upon acceptance, the galley of researchers, authors, and reviewers proofs of these selected in the field.” manuscripts are prepared and sent to the author on an Richard N. Armstrong, Editor, Biochemistry expedited schedule to facilitate Vanderbilt University School of Medicine, Department of Biochemistry more rapid online and print publication. JOC Featured In 2008, Biochemistry introduces Rapid Reports, a brief, new Articles are then listed online as Article ASAPs on the JOC home expedited manuscript type. Reserved for timely topics of page as soon as the corrected unusual interest, Rapid Reports are posted online as Articles galley proof is returned. They ASAP on an expedited schedule and are also immediately are also posted on a special JOC indexed on the Biochemistry Rapid Reports webpage. Rapid Featured Articles page, and Reports are limited to three printed journal pages and authors printed in the next available are asked to adhere to specific guidelines when submitting their print issue of the journal. work. Guidelines may be found on the new ACS Paragon Plus Environment website at http://pubs.acs.org/paragonplus. We are very pleased with the community’s reaction to this new feature in the journal, and have numerous entries already published by notable researchers in the field, including Jean-Marie Lehn, Sidney Hecht, Amos B. Smith III, Michael Crimmins, and Gary Molander to name just a few.

With over 70 years of published research, JOC has always welcomed contributions from international authors. The number of these contributions has increased greatly with the advent of online manuscript submission over the past 5+ years. While the “paper” era of yielded substantially fewer global contributions due to cost and timeliness concerns, Web- based submission has facilitated the growth of the journal’s international authorship by eliminating the difficulties associated with “paper” submission and review. This change in the peer review and submission system along with the advent of the ACS Web Editions has affected the overall authorship in the journal to One of the first from Chapman et al, the extent that in 2007, publications in the journal were almost posted on March 13, 2008 equally divided among the Americas, Europe, and Asia and the Pacific. A Rapid Report must include a short abstract (100 words maximum), a main body of text that includes (without In recognition of the international growth subheadings) an introduction, a brief and general description of of the journal, in 2008, JOC welcomes experimental procedures, and the results and discussion of the Carsten Bolm, Professor of Organic work accompanied by tables, schemes, structures, figures, and Chemistry at RWTH Aachen University in references. Germany, as its first international Associate Editor. Carsten has served on the Editorial Authors are expected to submit detailed experimental Advisory Board of JOC for the past 2 years. procedures as Supporting Information that are sufficient for Editor-in-Chief C. Dale Poulter and the others to reproduce the reported results. Authors are encouraged Carsten Bolm Associate Editors look forward to working to submit Rapid Reports using the specific guidelines. Professor of Organic Chemistry with him in his new role as an editor. Biochemistry will make every effort to come to an editorial Aachen University, Germany decision on Rapid Reports within three weeks of receipt of the manuscript.

16 EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1 ❂ ACS Editor Delegation Travels to China With manuscript submissions from Materials Editor-in-Chief Leonard Interrante The recent visits and engagements by ACS China increasing rapidly in recent years, of Rensselaer Polytechnic Institute both Editors in 2007 follow a successful editor ACS Editors have been reaching out to accepted invitations to speak at the 9th delegation to China in 2006, and are further strengthen ties with Chinese researchers. International Symposium on Polymers recognition of the significant contributions In October 2007, several ACS journal for Advanced Technologies (PAT) held in to chemistry and the related sciences by editors, accompanied by ACS Publications Shanghai, China, October 22-25, 2007. the many authors and researchers in the staff, traveled to Asia to gain a better While at the conference, Dr. Albertsson region. These efforts are complemented understanding of current research being and Dr. Interrante participated in a “Meet by other ACS Editors traveling to and done in China and Japan, and to help the Editor” event at the ACS Publications presenting in the region on a regular basis the researchers in those countries gain exhibit booth. In addition, both Editors including C. Dale Poulter of the University insights into what ACS Journal Editors visited local Fudan and Shanghai Jiao Tong of Utah, Editor-in-Chief of The Journal of look for in the articles they publish. Universities to meet with faculty, tour lab Organic Chemistry, James N. Seiber of the facilities, and speak about their own research Western Regional Research Center of the and topics related to journal publishing. USDA, Editor-in-Chief of the Journal of In conjunction with the conference, Agricultural and Food Chemistry, and Peter Dr. Interrante also held an Editorial J. Stang of the University of Utah, Editor- Advisory Board meeting for his journal. in-Chief of the Journal of the American Chemical Society to name just a few. In a separate trip that also took place in October, Langmuir Editor-in-Chief David Whitten of the University of New Mexico, visited Osaka, Japan, to take part in the Langmuir Symposium in Osaka University 2007, held on October 8th and organized by the journal’s Senior Editor Tetsuro Majima. An Editorial Advisory Ann-Christine Albertsson, Editor-in-Chief of Biomacromolecules, talks to attendees at the Board meeting for Langmuir was held at Polymers for Advanced Technologies (PAT) Osaka in conjunction with the symposium. symposium in Shanghai, China. Following these events, Dr. Whitten traveled to China, where he visited and spoke at Biomacromolecules Editor-in-Chief Ann- Xiamen University, Fudan University, Christine Albertsson of the Royal Institute of , and . Technology in Stockholm, and Chemistry of In addition, Dr. Whitten held an Editorial left to right: Jack Ochs, ACS Publications; Leonard Interrante, Editor-in-Chief, Chemistry of Materials; Advisory Board meeting for the journal Ann-Christine Albertsson, Editor-in-Chief, at the Institute of Chemistry the Chinese Biomacromolecules; James Liu, ACS Publications, at Academy of Sciences (ICCAS) in Beijing. the PAT symposium in Shanghai, China

17 EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1 ❂ !#30UBLICATIONS %XCELLENCEIN"IOLOGICAL-EDICINAL#HEMISTRY ACS Publications features an essential roster Chemical Research in Toxicology Organic Letters of journals that offer you the most innovative Editor: Lawrence J. Marnett Editor-in-Chief: Amos B. Smith, III and landmark research findings in the field Volume: 21, 12 Issues Volume: 10, 24 Issues of chemistry and beyond. With a growing Impact Factor: 3.162 Impact Factor: 4.659 collection of over 600,000 original research articles representing more than 125 years of Journal of Chemical Information and Organometallics scientific advancement, ACS Publications Modeling Editor-in-Chief: Dietmar Seyferth has long been a leader in chemistry as well as Editor-in-Chief: William L. Jorgensen Volume: 27, 24 Issues biologically-oriented research at the interface Volume: 48, 12 Issues Impact Factor: 3.632 Impact Factor: 3.423 between chemistry and biology. The most cited and highest impact journals Listed here are some of the ACS journals Journal of Combinatorial Chemistry in Chemistry also feature significant publishing significant biologically-oriented Editor: Anthony W. Czarnik biologically-oriented research: chemical research. Citation and Impact data Volume: 10, 6 Issues Journal of the American Chemical Society as reported in the 2006 Thomson Scientific Impact Factor: 3.153 Editor: Peter J. Stang Journal Citation Reports®. Journal of Medicinal Chemistry Volume: 130, 52 Issues ACS Chemical Biology Editor-in-Chief: Philip S. Portoghese Impact Factor: 7.696 Editor-in-Chief: Laura L. Kiessling Volume: 51, 24 issues Chemical Reviews Volume: 3, 12 Issues Impact Factor: 5.115 Editor: Josef Michl Biochemistry Journal of Natural Products Volume: 108, 12 Issues Editor: Richard N. Armstrong Editor-in-Chief: A. Douglas Kinghorn Impact Factor: 26.054 Volume: 47, 52 Issues Volume: 71, 12 Issues Accounts of Chemical Research Impact Factor: 3.633 Impact Factor: 2.418 Editor: Joan S. Valentine Bioconjugate Chemistry The Journal of Organic Chemistry Volume: 41, 12 Issues Editor-in-Chief: Claude F. Meares Editor-in-Chief: C. Dale Poulter Impact Factor: 17.113 Volume: 19, 12 Issues Volume: 73, 24 Issues All journals shown are indexed in PubMed/ Impact Factor: 3.823 Impact Factor: 3.790 MEDLINE®. Look for these other ACS Biomacromolecules Journal of Proteome Research journals also indexed in PubMed/MEDLINE®: Editor-in-Chief: Ann-Christine Albertsson Editor-in-Chief: William S. Hancock Analytical Chemistry, Inorganic Chemistry, Volume: 9, 12 Issues Volume: 7, 12 Issues Journal of Agricultural and Food Chemistry, Impact Factor: 3.664 Impact Factor: 5.151 The Journal of Physical Chemistry A, The Journal of Physical Chemistry B, Langmuir, Molecular Pharmaceutics Biotechnology Progress Macromolecules, Nano Letters Editor: Jerome S. Schultz Editor-in-Chief: Gordon L. Amidon Volume: 24, 6 Issues Volume: 5, 6 Issues Impact Factor: 2.102

❂ !#3,AUNCHES"YTESIZE3CIENCE sEpisode 18 - A Recipe for the Pitcher Plant’s Chemical Concoction Bytesize Science is a new series of for Posted: Mon, 25 Feb 2008 10:00:04 -0400 young listeners created to be both educational and entertaining. Bytesize Science translates research sEpisode 17 - Rice that ‘Snaps, Crackles and Pops’ with Protein from the peer-reviewed journals of the ACS, along Posted: Tue, 19 Feb 2008 10:00:04 -0400 with content from Chemical & Engineering News, sEpisode 16 - New ingredients may keep us screaming for ice cream into lively stories about science, health, medicine, Posted: Mon, 11 Feb 2008 10:00:04 -0400 energy, food, and other topics. sEpisode 15 - Celebrating African-American Chemists New installments of Bytesize Science are posted every Wednesday and Posted: Mon, 4 Feb 2008 10:00:04 -0400 available without charge. For a sample, go to http://feeds.feedburner. com/BytesizeScience. sEpisode 14 - The mystery of shining fish solved at last! Posted: Mon, 28 Jan 2008 10:00:04 -0400 Recent “Episodes” of Bite Sized Science: sEpisode 13 - The secret jungles of ancient France sEpisode 20 - The e-Nose: Scientists try to develop an Posted: Mon, 14 Jan 2008 10:00:04 -0400 electronic sniffer Posted: Mon, 17 Mar 2008 10:00:04 -0400 sEpisode 12 - Germ chat: Learning the language of bacteria Posted: Mon, 17 Dec 2007 10:00:04 -0400 sEpisode 19 - An egg-straordinary discovery to help kids with egg allergy sEpisode 11 - The water strider’s amazing belly flop Posted: Tue, 3 Mar 2008 10:00:04 -0400 Posted: Tue, 11 Dec 2007 10:00:04 -0400

18 EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1 ❂ Congratulations to Gabor Somorjai on His Selection as the 2008 Priestley Medalist ACS Publications work spans The Journal of Physical Chemistry, In addition to his written contributions to ACS, would like to extend Macromolecules, Nano Letters, Journal of Dr. Somorjai is also the father of Nano Letters its most sincere the American Chemical Society, Langmuir, Coordinating Editor Dr. Nicole S. Alivisatos, congratulations to Chemistry of Materials, Accounts of Chemical and served as research advisor to The Journal of Gabor A. Somorjai Research, Chemical Reviews, Industrial & Physical Chemistry Senior Editor Dr. Francisco on his being Engineering Chemistry Research Fundamentals, Zaera. ACS Publications congratulates Dr. awarded the 2008 and Energy & Fuels. Somorjai for his award and thanks him for Priestley Medal in his numerous contributions to ACS journals recognition of his The Journal of Physical Chemistry Festschrift as well as to the advancement of the scientific “extraordinarily in his honor notes, “Comments must also enterprise. creative and original be made about Gabor’s other, and really 2008 Priestley Medalist contributions to overarching, contribution to the development To view more Gabor A. Somorjai (see pages 13 & 14 for more surface science of the field of surface chemistry. That is details about ACS National Awards Honorees) and catalysis.” his contribution as teacher and effective Gabor Somorjai’s Widely considered as the father of modern spokesman for the field. Over the past thirty- research, surface chemistry, the methods that Somorjai five years he has trained more than ninety publications, developed have been invaluable for elucidating graduate students and more than one hundred awards and chemical reaction pathways in heterogeneous postdoctoral associates. These students and honors, and (surface) catalysis with his contributions research associates have had an enormous mentees see the leading to major advances in microelectronics impact on the practice of this science and its Gabor Somorjai and data storage technologies. development as a research field…. Gabor’s Festschrift unflagging enthusiasm for his science, his referenced above At the time of this publication, Somorjai has devotion to his students, and his ability to in The Journal of contributed 177 articles to ACS journals, which clearly express his ideas in the literature and in Physical Chemistry B, Volume 104, Issue 14. have been cited over 1,600 times. His lectures around the world have really identified the field of surface chemistry with him.”

❂ Join the American Chemical Society Today and Increase Your Chances for Positive Outcomes

ACS is the world’s largest scientific society for professionals in the chemical sciences. With more than 160,000 members, ACS membership connects you with your peers around the world and in your local community. Discover how ACS can further your professional career and take advantage of these cutting- edge members-only benefits: s Peer-to-Peer Mentoring - Get free, personalized career advice, not just generic guidance, but the insight of a focused on your own situation. Take advantage of the Career Consultant Program—a no cost service that is unique to ACS. s Find a Job - Post your resumé and gain access to job

postings in C&EN Classifieds two weeks before they are A page from the Membership made available to non-members. section at acs.org providing information to prospective members: “From aspiring scientists s Technical Divisions - First-time new members receive free at the high school level, to veteran chemists, ACS is here to support membership to one of more than 30 discipline specific its members and enhance their technical divisions for one year. This is an opportunity to professional development.” network with colleagues in your area of professional interest. s Chemical & Engineering News (C&EN) - Your membership includes a free subscription to the leading news magazine of the chemical world, C&EN, published weekly. International members can now save $58 on postage by choosing the C&EN electronic delivery option. For more information on membership, please visit www.acs.org ACS Members chat at the recent 234th ACS National Meeting

19 EXCELLENCE NEWSLETTER - VOL. 2 - ISSUE 1