National Academy of Sciences of the UNITED STATES of AMERICA

Proceedings OF THE National Academy of Sciences OF THE UNITED STATES OF AMERICA

Offcers FRANK PRESS, President ofthe JAMES D. EBERT, Vice President Academy BRYCE CRAWFORD, JR., Home Secretary WALTER A. ROSENBLITH, Foreign Secretary ELKAN R. BLOUT, Treasurer Editorial Board DANIEL E. KOSHLAND, JR., Chairman of the ROBERT A. ALBERTY ROBERT E. MARSHAK J. EDWIN SEEGMILLER Proceedings PAUL BERG DANIEL NATHANS ROBERT L. SINSHEIMER JOHN R. BORCHERT PETER H. RAVEN SOLOMON H. SNYDER RONALD BRESLOW JOHN RODGERS FRANK H. WESTHEIMER PETER D. LAX NEVIN S. SCRIMSHAW JAMES B. WYNGAARDEN Managing Editor: FRANCES R. ZWANZIG Senior Associate Editor: GARY T. COCKS Associate Editor: CAY BUTLER Associate Editor: JOHN M. MALLOY Associate Editor: T. PEARSON Associate Editor: DOROTHY P. SMITH Assistant Managing Editor: JOANNE D'AMICO Senior Production Editor: LYNN A. BROWN Production Editors: BARBARA A. BACON, RUTH E. CROSSGROVE, P. J. GROFF, PEGGY LEONARD, MICHAEL W. NEFF, JANET L. OVERTON, ERIC R. WASSYNG Administrative Assistants: DELORES BANKS, BEULAH EDWARDS Manuscript Coordinators: CYNDY MATHEWS, JACQUELINE PERRY Circulation: JULIA LITTLE, VIRGINIA TREADWAY Editorial correspondence: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, Washing- ton, DC 20418. Business correspondence: Circulation Office of the PROCEEDINGS, National Academy of Sciences, 2101 Constitution Ave- nue, Washington, DC 20418. Information for Contributors: See issue Number 1, January 1984.

Copyright: The National Academy of Sciences has copyrighted this journal as a collective work and does not own copy- rights for individual articles. Requests for permission to reproduce parts of individual articles or for reprints of individual articles should be addressed to the authors. Microforms of complete volumes are available to regular subscribers only and may be obtained from University Microfilms, Xerox Corporation, Ann Arbor, MI 48103. Subscriptions: All correspondence concerning subscriptions should be addressed to the Circulation Office ofthe PROCEED- INGS. Subscriptions are entered on a calendar year basis only. For 1985, subscription rates are as follows-in the United States: personal, $185; institutional, $215; elsewhere: personal, $220; institutional, $250. Subscribers are requested to notify the Circulation Office of the PROCEEDINGS 6 weeks in advance of any change of address; also the local postmaster. The Academy is not responsible for nonreceipt of issues because of an improper address unless a change of address is on file. The notice of address change should list both the old and new addresses. Claims for replacement copies will not be honored more than 60 days after the issue date for domestic subscribers and not more than 90 days after the issue date for foreign subscribers. Back Issues: Volumes 76-81, January 1979 and thereafter, are available from the Circulation Office of the PROCEEDINGS. The price of a single issue is $21.00 for Volumes 76-78 or $11.00 for Volumes 79-81.

Second class postage paid at Washington, DC, and at additional mailing offices. PRINTED IN THE USA

X 1984 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. POSTMASTER: Send address changes to: PROCEEDINGS, 2101 Constitution Ave., Washington, DC 20418. Proceedings OF THE National Academy of Sciences OF THE UNITED STATES OF AMERICA

November 1984 Volume 81, Number 22 pp. 6909-7268 Table of Contents

AUTHOR INDEX vii

Biological Sciences

BIOCHEMISTRY Characterization and regulation in the expression of a gene coding for the Yassemi G. Capetanaki, John Ngai, and 6909 intermediate filament protein desmin Elias Lazarides Inhibition of human natural killer cell activity by (14R,15S)-14,15-dihydroxy- Urban Ramstedt, Charles N. Serhan, Ulf 6914 5Z,8Z,10E,12E-icosatetraenoic acid Lundberg, Hans Wigzell, and Bengt Samuelsson Regulation of polyomavirus transcription by large tumor antigen William G. Farmerie and William R. Folk 6919 A product of yeast RAS2 gene is a guanine nucleotide binding protein Fuyuhiko Tamanoi, Martin Walsh, Tohru 6924 Kataoka, and Michael Wigler Regulation of ribosomal RNA promoters with a synthetic lac operator Jurgen Brosius and Adriana Holy 6929 Coagulation factors V and VIII and ceruloplasmin constitute a family of William R. Church, Robert L. Jernigan, 6934 structurally related proteins Jay Toole, Rodney M. Hewick, John Knopf, Gaylord J. Knutson, Michael E. Nesheim, Kenneth G. Mann, and David N. Fass A protein kinase activity tightly associated with Drosophila type II DNA Miriam Sander, James M. Nolan, and 6938 topoisomerase Tao-shih Hsieh Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to Ramesh C. Gupta 6943 repetitive sequences of rat liver DNA in vivo Isolation and characterization of a cDNA clone for the y subunit of bovine James B. Hurley, Henry K. W. Fong, 6948 retinal transducin David B. Teplow, William J. Dreyer, and Melvin I. Simon i AUTHOR INDEX, NOVEMBER 1984

Abe, E. 7112 French, R. 7066 Lathe, R. 7194 Adkins, B. 7122 Fujiki, Y. 7127 Lazarides, E. 6909 Ahlquist, P. 7066 Fullerton, D. S. 7258 Lazarow, P. B. 7127 Andrew, D. J. 7031 Garrett, C. E. 6993 Lazdunski, M. 7228 Babbitt, P. C. 7007 Gee, K. W. 7248 Lecocq, J.-P. 7194 Baird, A. 6963 Geiduschek, E. P. 7031 Leder, P. 7161 Baltimore, D. 7041 Gerok, W. 7036 Li, J. J. 6973 Banerjee, P. T. 7056 Gibbons, J. T. 7108 Li, Q.-q. 7079 Basch, R. S. 7176 Gilbert, W. 7189 Lichten, M. 7180 Baxter, J. D. 7007 Giovanazzo, B. 7166 Linial, M. 7258 Berbers, G. A. M. 7017 Gluschankof, P. 7003 Loesch-Fries, L. S. 7066 Bergman, Y. 7041 Gold, L. 7061 London, I. M. 6998 Berman, J. W. 7176 Goldstein, A. 7253 Lui, G.-M. 6963 Betz, H. 7224 Gomez, S. 7003 Lundberg, U. 6914 Beug, H. 7122 Goodenow, M. M. 7258 Macfarlan, R. I. 7194 Bishop, J. G., III 7146 Gospodarowicz, D. 6963 Mackett, M. 7194 Blanchard, J. M. 7046 Govindjee, R. 7079 Mann, K. G. 6934 Bloemendal, H. 7017 Graf, T. 7122 Manne, V. 6953 Blum, H. 7212 Greene, J. R. 7031 Marshall, J. D. 7199 Bohlent, P. 6963 Greengard, P. 6968 Marty, L. 7046 Bonamy, C. 7012 Grenningloh, G. 7224 Masiello, N. C. 7199 Bouvier, J. 7012 Grosschedl, R. 7041 Matern, H. 7036 Brennan, S. M. 7031 Guiney, D. G. 7203 Matern, S. 7036 Brinton, R. E. 7248 Gupta, R. C. 6943 Matts, R. L. 6998 Brosius, J. 6929 Haas, I. G. 7185 May, L. T. 7171 Cahill, A. L. 7243 Haase, A. 7212 Mendez, B. 7007 Capasso, J. M. 7051 Hanamoto, J. H. 7083 Miles, K. 6968 Capetanaki, Y. G. 6909 Hark, S. I. 7233 Miyaura, C. 7112 Carson, H. L. 7146 Harris, J. D. 7212 Morel, A. 7003 Chavkin, C. 7253 Hasegawa, P. 7203 Moss, B. 7194 Cheng, J. 6963 Hayaishi, 0. 7132 Mui, S. C. 7056 Church, W. R. 6934 Hayashi, T. 7112 Mulligan, R. C. 7151 Claviez, M. 7117 Hayward, W. S. 7258 Muniyappa, K. 7026 Cline, M. J. 7141 Heinrikson, R. L. 7031 Nesheim, M. E. 6934 Cohen, P. 7003 Heller, H. 7021 Ngai, J. 6909 Cohn, Z. A. 7258 Hennessy, K. 7207 Nicolas, J.-F. 7137 Cole, T. 7207 Herron, G. S. 7258 Nishii, Y. 7112 Cone, R. 7151 Hershko, A. 7021 Niwa, 0. 7132 Coussens, P. M. 7071 Hewick, R. M. 6934 Nolan, J. M. 6938 Croce, C. M. 7166 Hirschberg, C. B. 7051 Norment, A. 6993 Curtis, P. J. 7194 Hoekman, W. A. 7017 Nowell, P. C. 7166 Dani, Ch. 7046 Holy, A. 6929 Ohashi, Y. 7132 Davis, C. E. 7203 Howard, G. C. 6958 Palumbo, A. 7166 Davis, T. P. 7248 Howells, R. D. 7221 Parak, F. 7088 de Jong, W. W. 7017 Hsieh, T.-s. 6938 Pegoraro, L. 7166 DeLuca, H. F. 7112 Huganir, R. L. 6968 Pellicer, A. 7176 Dick, A. P. K. 7233 Hugues, M. 7228 Perlman, R. L. 7243 Dietzschold, B. 7194 Hummel, M. 7207 Perlmutter, A. P. 7189 Dodson, E. J. 7093 Hunt, J. A. 7146 Peterson, G. L. 7258 Dodson, G. G. 7093 Hurley, J. B. 6948 Petryshyn, R. 6998 Dreyer, W. J. 6948 Iino, M. 7103 Pfeiffer, F. 7224 Dujon, B. 7156 Ikai, K. 7132 Pflugfelder, G. 6958 Dupuis, P. 7083 Jacob, F. 7137 Piechaczyk, M. 7046 Ebrey, T. G. 7079 Jaenisch, R. 7151 Pilot, T. J. 6983 Elgin, S. C. R. 6958 Jakubowski, M. L. 7108 Potter, H. 7161 El Sabouty, S. 7046 Janda, M. 7066 Putzer, H. 7117 El-Sayed, M. A. 7083 Javaherian, K. 6958 Rachubinski, R. A. 7127 Emanuel, B. S. 7166 Jeanteur, Ph. 7046 Ramstedt, U. 6914 Erickson, B. W. 7171 Jernigan, R. L. 6934 Reagan, K. J. 7194 Erikson, J. 7166 Kahn, P. 7122 Reynolds, C. D. 7093 Eytan, E. 7021 Kaklij, G. 7021 Rice, D. 7041 Fafeur, V. 7003 Kalderon, N. 7216 Richards, S. H. 7031 Falda, M. 7166 Kanegasaki, S. 7112 Romey, G. 7228 Fangman, W. L. 7156 Kanwar, Y. S. 7108 Rose, I. A. 7021 Farmerie, W. G. 6919 Kataoka, T. 6924 Rosenberg, M. 6988 Fass, D. N. 6934 Kelly, T. J. 6973 Rosenzweig, L. J. 7108 Feenstra, R. W. 7017 Kieff, E. 7207 Roths, J. B. 7199 Fennewald, S. 7207 Kieny, M.-P. 7194 Rovera, G. 7166 Ferguson, B. 6988 Kilpatrick, D. L. 7221 Rubenstein, J. L. R. 7137 Fleischmann, G. 6958 Klip, A. 7233 Saito, M. 7112 Fleminger, G. 7221 Knapp, E. W. 7088 Samuelsson, B. 6914 Flory, J. 7026 Knopf, J. 6934 Sander, M. 6938 Folk, W. R. 6919 Knutson, G. J. 6934 Santi, D. V. 6993 Folkers, K. 7076 Ko, S. S. 7258 Saunders, R. 7061 Fong, H. K. W. 6948 Koprowski, H. 7194 Schafer, E. 7103 Fosset, M. 7228 Krippl, B. 6988 Schimerlik, M. I. 7258 Fox, J. L. 6983 Kung, H.-F. 6953 Schmid-Antomarchi, H. 7228 Fox, M. S. 7180 LaGree, K. 7056 Schreckenbach, T. 7117

vii AUTHOR INDEX, NOVEMBER 1984

Scott, J. 7212 Szulmajster, J. 7012 Walsh, M. 6924 Sehgal, P. B. 7171 Tamanoi, F. 6924 Wamsley, J. K. 7248 Serhan, C. N. 6914 Tanaka, H. 7112 Wang, J. C. 6958 Shalloway, D. 7071 Teplow, D. B. 6948 Weber, G. 7098 Shih, C.-K. 7258 Thomas, N. S. B. 6998 Weir, L. 7161 Shiina, Y. 7112 Thompson, C. C. 7031 West, B. L. 7007 Shultz, L. D. 7199 Toole, J. 6934 Westphal, H. 6988 Sidman, C. L. 7199 Traynor, B. 7212 Wigler, M. 6924 Simler, R. 7224 Tsang, S. S. 7026 Wigzell, H. 6914 Simon, M. I. 6948 Udenfriend, S. 7221 Wiktor, T. J. 7194 Slamon, D. J. 7141 Ueda, K. 7132 Wolaniuk, A. 7076 Smith, G. D. 7093 Vadhanavikit, S. 7076 Wooldridge, D. E. 7238 Steiner, E. K. 6958 van den Bos, R. 7017 Wunner, W. H. 7194 Stormo, G. 7061 Vary, C. P. H. 6978 Yaciuk, P. 7071 Stragier, P. 7012 Ventura, P. 7212 Yamaki, M. 7258 Strauss, P. R. 7056 Verfuerth, C. 7117 Yamamura, H. I. 7248 Stuhlmann, H. 7151 Vournakis, J. N. 6978 Yamazaki, S. 6953 Suda, T. 7112 Wabl, M. R. 7185 Young, J. D.-E 7258 Swenson, D. C. 7093 Walker, D. M. 7233

viii Proceedings OF THE National Academy of Sciences OF THE UNITED STATES OF AMERICA

Officers FRANK PRESS, President of the JAMES D. EBERT, Vice President Academy BRYCE CRAWFORD, JR., Home Secretary WALTER A. ROSENBLITH, Foreign Secretary ELKAN R. BLOUT, Treasurer Editorial Board DANIEL E. KOSHLAND, JR., Chairman of the ROBERT A. ALBERTY ROBERT E. MARSHAK J. EDWIN SEEGMILLER Proceedings PAUL BERG DANIEL NATHANS ROBERT L. SINSHEIMER JOHN R. BORCHERT PETER H. RAVEN SOLOMON H. SNYDER RONALD BRESLOW JOHN RODGERS FRANK H. WESTHEIMER PETER D. LAX NEVIN S. SCRIMSHAW JAMES B. WYNGAARDEN Managing Editor: FRANCES R. ZWANZIG Senior Associate Editor: GARY T. COCKS Associate Editor: CAY BUTLER Associate Editor: JOHN M. MALLOY Associate Editor: T. PEARSON Associate Editor: DOROTHY P. SMITH Assistant Managing Editor: JOANNE D'AMIco Senior Production Editor: LYNN A. BROWN Production Editors: BARBARA A. BACON, RUTH E. CROSSGROVE, P. J. GROFF, PEGGY LEONARD, MICHAEL W. NEFF, JANET L. OVERTON, ERIC R. WASSYNG Administrative Assistants: DELORES BANKS, BEULAH EDWARDS Manuscript Coordinators: CYNDY MATHEWS, JACQUELINE PERRY Circulation: JULIA LITTLE, VIRGINIA TREADWAY Editorial correspondence: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, Washing- ton, DC 20418. Business correspondence: Circulation Office of the PROCEEDINGS, National Academy of Sciences, 2101 Constitution Ave- nue, Washington, DC 20418. Information for Contributors: See issue Number 1, January 1984.

Copyright: The National Academy of Sciences has copyrighted this journal as a collective work and does not own copy- rights for individual articles. Requests for permission to reproduce parts of individual articles or for reprints of individual articles should be addressed to the authors. Microforms of complete volumes are available to regular subscribers only and may be obtained from University Microfilms, Xerox Corporation, Ann Arbor, MI 48103. Subscriptions: All correspondence concerning subscriptions should be addressed to the Circulation Office of the PROCEED- INGS. Subscriptions are entered on a calendar year basis only. For 1985, subscription rates are as follows-in the United States: personal, $185; institutional, $215; elsewhere: personal, $220; institutional, $250. Subscribers are requested to notify the Circulation Office of the PROCEEDINGS 6 weeks in advance of any change of address; also the local postmaster. The Academy is not responsible for nonreceipt of issues because of an improper address unless a change of address is on file. The notice of address change should list both the old and new addresses. Claims for replacement copies will not be honored more than 60 days after the issue date for domestic subscribers and not more than 90 days after the issue date for foreign subscribers.

Back Issues: Volumes 76-81, January 1979 and thereafter, are available from the Circulation Office of the PROCEEDINGS. The price of a single issue is $21.00 for Volumes 76-78 or $11.00 for Volumes 79-81.

Second class postage paid at Washington, DC, and at additional mailing offices. PRINTED IN THE USA

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (ISSN-0027-8424) is pub- lished semimonthly by THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, Washington, DC 20418. © 1984 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. POSTMASTER: Send address changes to: PROCEEDINGS, 2101 Constitution Ave., Washington, DC 20418. Proceedings OF THE National Academy of Sciences OF THE UNITED STATES OF AMERICA

November 1984 Volume 81, Number 22 pp. 6909-7268 Table of Contents

AUTHOR INDEX iii

Biological Sciences 6909

Physical Sciences

MATHEMATICS Isometric embeddings of graphs R. L. Graham and P. M. Winkler 7259 On applications of diophantine approximations G. V. Chudnovsky 7261

PHYSICS Reduction of scattering to an invariant finite displacement in an ambient I. E. Segal 7266 space-time

i AUTHOR INDEX, NOVEMBER 1984

Chudnovsky, G. V. 7261 Graham, R. L. 7259 Segal, I. E. 7266 Winkler, P. M. 7259

iii