RESEARCH ARTICLE A theory of how active behavior stabilises neural activity: Neural gain modulation by closed-loop environmental feedback Christopher L. Buckley1,2*, Taro Toyoizumi1* 1 Laboratory for Neural Computation and Adaptation, RIKEN Brain Science Institute, Saitama, Japan, 2 Department of Informatics and Engineering, University of Sussex, Falmer, United Kingdom *
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[email protected] (TT) a1111111111 a1111111111 a1111111111 a1111111111 Abstract a1111111111 During active behaviours like running, swimming, whisking or sniffing, motor actions shape sensory input and sensory percepts guide future motor commands. Ongoing cycles of sen- sory and motor processing constitute a closed-loop feedback system which is central to motor control and, it has been argued, for perceptual processes. This closed-loop feedback OPEN ACCESS is mediated by brainwide neural circuits but how the presence of feedback signals impacts Citation: Buckley CL, Toyoizumi T (2018) A theory on the dynamics and function of neurons is not well understood. Here we present a simple of how active behavior stabilises neural activity: Neural gain modulation by closed-loop theory suggesting that closed-loop feedback between the brain/body/environment can mod- environmental feedback. PLoS Comput Biol 14(1): ulate neural gain and, consequently, change endogenous neural fluctuations and responses e1005926. https://doi.org/10.1371/journal. to sensory input. We support this theory with modeling and data analysis in two vertebrate pcbi.1005926 systems. First, in a model of rodent whisking we show that negative feedback mediated by Editor: Daniel Bush, University College London, whisking vibrissa can suppress coherent neural fluctuations and neural responses to sen- UNITED KINGDOM sory input in the barrel cortex.