Authors: Ingrid Keseler Anamika Kothari Ron Caspi Carol A Fulcher An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Markus Krummenacker Amanda Mackie Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. BsubCyc: Bacillus subtilis subtilis 168 Cellular Overview Connections between pathways are omitted for legibility. Pallavi Subhraveti β-D-GlcA- (1->4)-β- D-GlcA- (1->3)-α- D-GalNAc- (1->6)-α- L-carnitine D-methionine D-GalNAc- [(2-Glc)-Gro-P] -Gro-P-ManNAc-GlcNAc-PP-undecaprenol choline sulfate n arsenite a proteinogenic glycine glycine betaine pro glu L-methionine S-oxide PP-Und a polyisoprenyl-minor wall teichoic acid (B. subtilis 168) choline D-glucopyranose myo-inositol 2-oxoglutarate D-sorbitol pro phosphate maltose amino acid a dipeptide a maltodextrin met betaine choline

D-mannitol 4-aminobutanoate N-acetyl-D- glycine pro muramate betaine/ methionine wall teichoic carnitine/ choline ABC phosphotransferase phosphate dipeptide maltodextrin TmrB YhzF FtsY YobW YdhB YufS YjgA YfjD YddI EpsL YvkA AraN YbaS NarK YndK YhaL YqhP YhjO ComEC YkoI LevR YclH YhjB YcnJ RsgI TlpC ABC YuiF YfkF YqbC PbuO YtvB ResA GtcA YvcA TuaB YczM HbuT FtsW AppF PbpB YxeB YtbD GerD YfkR YfjE YvrP acid ABC TnrA YkcC TseB YozV YobI ArsB YfhA LnrJ OpuA choline/ transporter YdbK YfiU PtsG YfkC LepA YpmS CstA YxeR YerH YybF IolT YflS YitP system (PTS) GutP NdhF GabP PutP OpuE GltP SteT YfmO YabM YvoD YdfP YvgL IolF YvjA BsrG YtrD FlhB AlsT ABC MalP YbgF Mdr FliP ABC YtwI ABC YhdT YvfR MurP YwzB GlcP YxlC YoyD YdbI LytA YosE YocA YcbM YfhP SdpB SeaA YczC FliR YttA XhlA YpbE YoaT NorM RocC YvfS YmaG TetB SpmA FadF YnxB YtjA YteU YncB PsiE 02585 YotH YwcB YciB YndF YddM YocR YwbA YvzJ CcdA YubA YtrE BsrE transporter transporter choline OpuB mannitol-specific transporter transporter transporter YycB sulfate ABC YlqH β-D-GlcA- transporter (1->4)-β- [(2-Glc)-Gro-P] -Gro-P-ManNAc-GlcNAc-PP-undecaprenol arsenite glycine D-glucopyranose 4-aminobutanoate α-maltose 6'- N-acetyl-D- n myo-inositol 2-oxoglutarate D-sorbitol a proteinogenic D-methionine a polyisoprenyl-minor wall teichoic acid (B. subtilis 168) betaine 6-phosphate D-mannitol pro pro pro glu phosphate muramate 6- D-GlcA- choline amino acid a dipeptide a maltodextrin L-methionine S-oxide (1->3)-α- 1-phosphate phosphate phosphate YvaC YvgM met D-GalNAc- L-carnitine (1->6)-α- choline sulfate D-GalNAc- glycine betaine L-alanyl-γ-D- PP-Und YhcC choline glutamyl-meso-2,6- YdeJ diaminopimeloyl- Amino Acid Degradation Cofactor, Carrier, and Vitamin Biosynthesis Detoxification D-alanine superpathway of glycolysis and the Entner-Doudoroff pathway di-trans,octa-cis a UDP-N- a glycopeptide- N-acetyl-D- a (3R)-3- a (3R)-3- β arbutin 6- (R)-S- a nucleoside a [release factor]- β L-valine degradation I a -D-galactoside 4 monochlorobimane bacillithiol carbonic acid a -lactam superpathway of menaquinol-7 biosynthesis Tetrapyrrole Biosynthesis L-leucine degradation I L-histidine degradation I superoxide -undecaprenyl acetylmuramoyl- D-mannosyl-N a purine phosphate lactoylglutathione muramate 6- hydroxyoctadecanoyl- RNA hydroxyicosanoyl- L-glutamine YwbF superpathway of tetrahydrofolate biosynthesis and salvage superpathway of tetrahydrofolate biosynthesis superpathway of coenzyme A biosynthesis I (bacteria) flavin biosynthesis I (bacteria and plants) base-degraded L-cysteine biosynthesis thiamine diphosphate salvage II NAD de novo biosynthesis folate transformations III (E. coli) L-isoleucine degradation I L-arginine arginine triphosphate LD- molybdopterin biosynthesis Metabolic Regulator Biosynthesis D-glucopyranose 6-phosphate radicals arsenate phosphate pentapeptide -(N-acetyl-D- ribonucleoside phosphate [acp] [acp] glutamine exported XynP thiamine salvage VI (from L-methionine) I (from aspartate) degradation VI dependent beta- beta- carboxypeptidase: degradation detoxification II glucosaminyl) methylase beta- chorismate 3-methyl-2- a 5,10- 4-amino-2-methyl-5- tetrapyrrole biosynthesis val (arginase 2 pathway) acid resistance short chain bacillithiol S- 6-phospho- glyoxalase I; hydroxyacyl- hydroxyacyl- carbonic ldcB formylaminopyrimidine a tetrahydrofolate ATP siroheme biosynthesis ppGpp metabolism leu his -asparagine DNA- of release lactamase: pyrimidinemethanol I (from glutamate) ile superoxide phospho-N- beta-1,4-galacto- 2 D-lactyl ether N- [acyl carrier [acyl carrier GTP GTP oxobutanoate methylenetetrahydrofolate GTP N-formyl-4-amino- met asp nitric oxide glycine betaine arsenate transferase: bstH beta- hemithioacetal- anhydrase: muropeptide L,D- KhtT menaquinone- glucose-6-phosphate branched-chain arg histidine arg acetylmuramoyl- purine nucleoside acetylmuramic-6- protein] dependent protein] factor ybxI arginine phosphomethylpyrimidine biosynthesis biosynthesis II (Gram- isoleucine-valine superoxide thioredoxin- oligosaccharides glucosidase: bacillithiol ytiB carboxypeptidase: specific 5-aminomethyl-2- S-adenosylmethionine molybdopterin cys GTP 1-dehydrogenase: zwf glucose-6-phosphate amino acid ammonia- bacillithiol S- phosphorylase: phosphate acid RNA 1 (and beta- ketopantoate L-aspartate glu uroporphyrinogen-III pppGpp III (bacteria) positive bacteria) aminotransferase / isoleucine-valine dismutase: arginine pentapeptide beta-galactosidase exported N- dehydratase: dehydratase: arg ABC arg ykfA isochorismate GTP GTP methylpyrimidine kinase, 4-amino-5- biosynthesis aminotransferase: ilvK arginase: argI lyase coupled transferase: bstG licH lactoyl-bacillithiol putative hydroxymethyltransferase: GTP synthetase: metK oxidase: nadB uroporphyrin-III C- isomerase: pgi aromatic amino acid aminotransferase / L-proline sodF decarboxylase: undecaprenyl (beta-galacto- acetylglucosaminidase deoD etherase: murQ fabZ polymerase: fabZ perhaps lactamase transporter synthase: menF cyclohydrolase cyclohydrolase deformylase: thiQ hydroxymethyl-2- adenylyltransferase: cysteine glutamyl-tRNA choline 4-methyl-2-oxopentanoate (histidase) arsenate bacillithiol S- aryl-6- formation: glxA carbonic panB cyclohydrolase: ribA SAM 2-iminosuccinate GTP 3',8- methyltransferase: nasF arg aromatic amino acid degradation I speA phosphate pyranoside (major autolysin) purine nucleoside yonO others) precursor: γ I: folEB I: folEB aminomethylpyrimidine methylpyrimidine and 4- moeB choline aminotransferase: L-ornithine [+ 2 isozymes] reductase: transferase: bstF putative putative anhydrase: L-alanyl- -D- YhfQ isochorismate desulfurase: cyclase: synthetase: gltX (p)ppGpp aminotransferase: : hutH hydrogen agmatine (C55P) hydrolase): ganA phosphorylase: phospho-beta- methylglyoxalase; N-acetyl-D- RNA at a GGQ penP Lgt 2,5-diamino-6-(5-phospho-D- amino-5-hydroxymethyl- quinolinate a carboxy- uroporphyrinogen nitric-oxide dehydrogenase: 6-phospho D-glucono-1,5-lactone ilvE branched-chain urocanate arsC (CWBP90): lytD hydroxyacyl- hydroxyacyl- D-ala glutamyl-meso- GTP GTP aminopyrimidine iscS an L-glutamyl-[tRNA Glu ] synthetase: sasB peroxide bacillithiol S- glucosidase: lactoylbacillithiol (R)-lactate site: prmC yvdA a substituted synthase dihydrofolate moaA III and precorrin-1 C- synthase ilvE alpha-keto acid ornithine pro transferase: mraY pupG glucosamine polymerase: a [release factor]- diaminopimelate cyclohydrolase cyclohydrolase 2-dehydropantoate ribosylamino)pyrimidin-4(3H)-one 2-methylpyrimidine synthetase: adenylated (8S)-3',8-cyclo-7,8- [+ 2 isozymes] gbsB branched-chain arsenous acid transferase: bstE bglA lyase: glxB (acyl carrier (acyl carrier β-amino acid (siderophore- asp amidohydrolase: [+ 3 isozymes] 6-phosphogluconolactonase: putative 6-phosphate rpoB rpoC 5 fused diaminohydroxyphosphoribosylaminopyrimidine pyrophosphate kinase: thiD nadA reductase: dfrA [small subunit of methyltransferase: sumT (flavodoxin) F6P branched-chain dehydrogenase E2 aminotransferase: proline urocanase: a non a glycopeptide- N-acetyl-D- protein) protein) N -methyl- I: folEA I: folEA tenA an [L-cysteine dihydroguanosine betaine aldehyde amino acid manganese- D-galactopyranose bacillithiol S- specific): dhbC serine glutamyl-tRNA precorrin-1 ω : nosA pgl glucosamine- α rpoA rpoE a reduced 7,8- 7,8- 2-dehydropantoate deaminase; 5-amino-6-(5- a 7,8-dihydrofolate a 5-methyltetrahydrofolate molybdopterin desulfurase]-S- N -hydroxy- aminotransferase: amino acid subunit (lipoamide rocD dehydrogenase hutU a N-acetylmuramoyl- UMP galactosylated D-mannosyl- -D-ribose- dehydratase: dehydratase: L-glutamine CO H O PgpH aspartate 1- 5'-triphosphate containing transferase: bstD β 2 2 reductase: panE 4-amino-2-methyl-5- SAH HMP-P 5-(2-hydroxyethyl) quinolinate hydroxymethyltransferase: glyA reductase: hemA GTP ppGpp glycine betaine fructose 1,6- aminotransferase: acyltransferase): bkdB pentapeptide- galactose acceptor N 4 -N-acetyl- asparagine 1-phosphate -D-glucose rpoZ rpoY H O c-type isochorismate dihydroneopterin dihydroneopterin phosphoribosylamino) uracil reductase: ribD synthase] sulfanyl-L-cysteine molybdenum uroporphyrin-III C- L-arginine ilvK L-glutamate-5- 1: fadM a purine base hydroquinone glutathione methylglyoxal ycsD ycsD 2 decarboxylase: aldehyde D-gluconate 6-phosphate bisphosphatase 4-imidazolone- catalase: [+ 3 isozymes] 6-phosphate cytochrome cytochrome Mpr 3'-triphosphate 3'-triphosphate 2-dehydropantoate pyrimidinemethanol -4-methylthiazole 6-phosphofructokinase: ilvK semialdehyde proline diphosphoundecaprenol D-glucosamine a (2E)-octadec- a (2E)-icos- an oxidized panD 5-amino-6-(5-phospho- 4-amino-2-methyl-5- nicotinate-nucleotide thymidylate homocysteine S- cofactor (S)-4-amino-5-oxopentanoate methyltransferase: nasF nitric-oxide class II: glpX 3-methylbutanoyl-CoA 5-propanoate ydbD arsenous acid caa3 oxidase 2-reductase: ylbQ S-adenosylhomocysteine dehydrogenase, 3-methyl-2-oxobutanoate 2-enoyl-[acp] 2-enoyl-[acp] O c-type 2-oxoglutarate D-ribosylamino)uracil hydroxyethylthiazole pyrophosphorylase: synthase A: thyA biosynthesis nucleoside pfkA (3S)-3-methyl-2- oxidase: putB 2 phosphomethylpyrimidine methyltransferase uroporphyrinogen GTP synthase NAD+- fructose-1,6- (S)-1-pyrroline- imidazolone- [+ 4 isozymes] RNA YjlA decarboxylase chorismate β-alanine nucleosidase: mtnN kinase: thiM nadC thymidylate a (6S)-5-formyltetrahydrofolate protein glutamate-1- diphosphate oxopentanoate isovaleryl-CoA bacillithiol-bimane cytochrome YwlD (R)-pantoate fused diaminohydroxyphosphoribosylaminopyrimidine kinase: thiD using (R,S)AdoMet and III and precorrin-1 C- pyrophosphokinase (flavodoxin) dependent: gbsA bisphosphatase: fbp branched-chain 5-carboxylate 5-propionate and 2-succinyl- 7,8- synthase B: thyB methylenetetrahydrofolate a thiocarboxylated C: moaC semialdehyde kinase: ndk dehydrogenase (leucine O 7,8- 4-amino-4- deaminase; 5-amino-6-(5- S-ribosyl-L- 4-methyl-5-(2- methylenetetrahydrofolate methyltransferase: sumT (RelA/SpoT): relA : nosA alpha-keto acid branched-chain hydrolase: hutI 2 5-enolpyruvyl- HMP-PP NaMN 5-formyltetrahydrofolate [small subunit of cyclic degradation): yngJ YukE dihydroneopterin dihydroneopterin phosphoribosylamino) uracil reductase: ribD phosphooxyethyl)thiazole reductase [NAD(P)H]: yitJ dehydrogenase; aminotransferase, glycine betaine KDGP β-D-fructose 1,6-bisphosphate dehydrogenase alpha-keto acid (S)-1-pyrroline- 6-hydroxy-3- deoxychorismate pantothenate homocysteine cyclo-ligase: yqgN molybdopterin pyranopterin precorrin-2 N-formimino- ATP 3'-phosphate 3'-phosphate methenyltetrahydrofolate class III nitric oxide dehydrogenase 5-carboxylate a protein with a [disulfide- ditrans,octacis- a peptide with a [DNA]-3'- a 5'-phospho- a [lipoyl-carrier a (3R)-3- a (3R,6Z)-3- + + synthase: 5-amino-6-(5-phospho- nicotinate-nucleotide GDP DHAP E2 subunit 3-methylcrotonyl-CoA Aromatic Compound Degradation + + H H synthetase: synthase] phosphate L-glutamate H O a lipid II FMN NADH H 6 NAD cyclohexene-1- cyclohydrolase: folD aminotransferase: undecaprenyldiphospho- diphosphate 2 Tyr hydroxydocosanoyl- hydroxyoctadec- synthase YbgB pabB pabA D-ribitylamino)uracil S-ribosylhomocysteine thiamine-phosphate adenylyltransferase: fructose-1,6- (lipoamide E2 subunit pyrroline-5- L-glutamate-5- reduced L- bond carrier an N-terminal hydroxyl [DNA] protein]-N -[(R) a D-tyrosyl-[tRNA ] a protein a protein carboxylic-acid panC D-ribulose 5-phosphate a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate gsaB precorrin-2 2-keto-3-deoxygluconate- lyase: luxS pyrophosphorylase nadD bisphosphate acyltransferase) (lipoamide methylcrotonoyl- carboxylate semialdehyde formiminoglutamate cysteine residues protein] carrying N-acetyl-(N- Xaa-L-proline -dihydrolipoyl]- [acp] beta- 6-enoyl-[acp]beta- inorganic serine synthase: menD (2S)-2-amino-4- 5-amino-6-(5- molybdopterin dehydrogenase: sirC 6-phosphate triose phosphate urate conversion to allantoin I membrane DctB 3,4-dihydroxy- (thiamine phosphate methylenetetrahydrofolate glutamate-1- aldolase: fbaA : bkdB acyltransferase) CoA carboxylase reductase: hydrolase: hutG a disulfide bond acetylglucosaminyl)muramate L-lysine acetoin hydroxyacyl- hydroxyacyl- polyphosphate/ D-erythro-7,8- D-erythro-7,8- deoxy-chorismate phospho-D- superpathway of thiamine diphosphate biosynthesis II nicotinate adenine synthase: aldolase: kdgA isomerase: tpiA 1-pyrroline-5- D-alanyl-D-alanine NAD(P)H-flavin ATP- bound serine alkaline YbxG 2-succinyl-5- 2-butanone L-homocysteine synthase): thiE dehydrogenase; semialdehyde 2,1- : bkdB subunit (leucine proG pyrophosphatase: dehydrogenase [acyl carrier [acyl carrier ATP-NAD kinase dihydroneopterin chorismate dihydroneopterin (R)-pantothenate ribitylamino)uracil dinucleotide moaD moaE sirohydrochlorin carboxylate aminopeptidase carboxypeptidase oxidoreductase dependent gly-tRNA(Ala) protease Do, protease Rny enolpyruvoyl- 4-amino-4- 4-phosphate aminomutase: hemL isobutanoyl-CoA (2S)-2- urate spore-specific ppaX (quinolate phosphatase: ycsE methenyltetrahydrofolate degradation): yngE pyrroline-5- dehydrogenase: glu peptidoglycan N- (Met-Xaa and (penicillin-binding DNA ligase E3 component deacylase / D- protein] protein] quality control (Ca(2+)- 6-hydroxy-3- dihydroneopterin dihydroneopterin deoxychorismate pantothenate a [ThiS sulfur- cystathionine NAD+ methylbutanoyl- urate oxidase with thiol-disulfide (nitroreductase) activated): nadF synthase: ribA cys cyclohydrolase: folD sirohydrochlorin D-glyceraldehyde 3-phosphate carboxylate putC acetylmuramic inorganic Xaa-Pro, Xaa- protein 5): dacA (dihydrolipoamide Tyr-tRNATyr dehydratase: dehydratase: protease and dependent cyclohexene- aldolase: folB aldolase: folB synthase: kinase type [+ 2 isozymes] carrier protein] β thiamine phosphate synthetase: 5-aminolevulinate 3-methylglutaconyl-CoA peroxide reductase N- oxidoreductase : hypO subunit; 5'-2- -synthase: molybdopterin ferrochelatase: sirB CoA reductase: D-serine acid deacetylase: pyrophosphatase Pro-Xaa): papA dehydrogenase) deacylase: dtd fabZ fabZ inorganic chaperone subtilisin WprA pabB pabA 1-deoxy-L-glycero- nadE 10 glyceraldehyde- delta-1-pyrroline- terminal domain: pucL (SpoVD [+ 3 isozymes] deoxyribose- YfiY 1-carboxylate 6-(hydroxymethyl) III: coaX ARP mccA an N -formyltetrahydrofolate proH degradation pdaA (Mn2+- NADPH-FMN : acoL polyphosphate/ (1R,6R)-2- 6-(hydroxymethyl) tetrulose 4-phosphate [sulfur-carrier cysteine delta-aminolevulinic methylglutaconyl-CoA 5 carboxylate cytosol 5-phosphate D-amino putative putative (heat-shock E): aprE 4-amino-4- 4-amino-4- thiamine- + 3-phosphate (S)-5-hydroxyisourate maturation): stoA oxidoreductase YdfR -7,8-dihydropterin -7,8-dihydropterin pantothenate protein ThiS] desulfurase: NAD siroheme pyrroline-5- dependent): ppaC a [lipoyl-carrier[+ 2 isozymes] ATP-NAD protein): htrA succinyl-6- deoxychorismate L-cystathionine monophosphate acid dehydratase dehydrogenase methylacrylyl-CoA hydratase (leucine dehydrogenase: aminopeptidase: a N- (dRP) acyl-tRNA hydroxyacyl- hydroxyacyl- a peptide deoxychorismate kinase: coaA Other Biosynthesis (nitroreductase) protein]-N 6 -[(R kinase: ppnKB 7,8-dihydro-6- 7,8-dihydro-6- adenylyltransferase: iscS (porphobilinogen (E)-2- degradation): yngF carboxylate rocA D-serine 5-hydroxyisourate a [disulfide-bond ditrans,octacis- pepA lyase: ligD deacylase: (acyl carrier (acyl carrier hydroxy-2,4- 4-amino-4- 6,7-dimethyl-8- kinase: thiL (NAD-dependent, D-ala acetylglucosamine- : ycnD a peptide hydroxymethylpterin hydroxymethylpterin 4-amino-4- (R)-4'- thiF [+ 3 isozymes] synthase): hemB enoyl-CoA methylcrotonoyl- reductase: proI a protein with acetate undecaprenyldiphospho- )-lipoyl]-L-lysine NADP + cyclohexadiene- ribityllumazine cystathionine 5,6-dimethylbenzimidazole glycolytic): gapA D-serine hydrolase: pucM carrier protein] + -N-acetylmuramyl- yabD protein) protein) 12875 YncM putative deoxychorismate deoxychorismate phosphopantothenate a carboxy- an [L-cysteine CoA HMG-CoA a disulfide bond (N-acetylglucosaminyl) phosphate H 1-carboxylate pyrophosphokinase: pyrophosphokinase: synthase: ribH gamma- thiamine diphosphate folate transformations I biosynthesis I (aerobic) 8-amino-7- hydratase: fadB glu ammonia- with reduced L- a peptide with (tetrapeptide) dehydratase: dehydratase: riboflavin pyruvate- pyruvate- adenylated-[ThiS desulfurase]-S- porphobilinogen (R,R)-butanediol enoyl-CoA (S)-2-oxo-4-hydroxy-4- δ a proteinogenic folK folK coenzyme A biosynthesis oxononanoate enoyl-CoA pro lyase: cysteine residues muramic -lactam + ycsD ycsD riboflavin riboflavin synthase: menH lyase: pabC synthase: metI S-adenosyl-L-methionine salvage I 13-DPG hydroxymethylglutaryl- carboxy-5-ureidoimidazoline an N-terminal pyrophosphoryl- FMNH NAD [DNA] a (2E,6Z)- ECF (1R,6R)-6-hydroxy- (7,8-dihydropterin- (7,8-dihydropterin- lyase: pabC bifunctional protein CoaBC; sulfur-carrier protein] sulfanyl-L-cysteine biosynthesis II biosynthesis hydratase: amino acid 2 riboflavin hydratase / 3- L-citrulline degradation dsdA L-proline undecaprenol D-tyrosine a tRNA Tyr a (2E)-docos- 6,7-dimethyl-8-(1-D-ribityl)lumazine a 5,10- porphobilinogen a long-chain fadB CoA lyase (leucine 2-aminoprop- 2-oxo-4-hydroxy- octadecadienoyl- transporter 2-succinylcyclohexa- 6-yl)methyl 4-aminobenzoate 6-yl)methyl phosphopantothenoylcysteine D-glyceraldehyde cys riboflavin kinase: ribC hydroxyacyl-CoA 2-enoyl-[acp] 4-aminobenzoate cysteine gly methylenetetrahydrofolate deaminase fatty acyl-[acyl- (R)-acetoin phosphoglycerate degradation): yngG 2-enoate 4-carboxy-5- [acp] YrhK SboA 2,4-diene-1- diphosphate diphosphate synthetase/decarboxylase: coaBC 3-phosphate dehydrogenase: enoyl-CoA YczN riboflavin desulfurase: SAH homocysteine S- homocysteine S- homocysteine S- RNA-binding (hydroxymethylbilane acetoin reductase/ kinase: pgk carboxylate (R)-4'- carrier protein]pimeloyl- hydratase / 3- acetoacetate L-citrulline ureidoimidazoline 1-deoxyxylulose- riboflavin kinase: ribR synthase): hemC fadN synthase: ribE iscS methyltransferase methyltransferase methyltransferase [acp] 2,3-butanediol decarboxylase: pucL 6 o-succinylbenzoate dihydropteroate dihydropteroate phosphopantothenoyl- 5-phosphate glycine FMN hydroxyacyl-CoA glycine cleavage ornithine UDP-N-acetyl-α-D-muramoyl- an O - a DNA containing salicin 6- D-gluconate (2E,9Z)- a triacyl-sn a peptide with a lignoceroyl- 3-phospho-D-glycerate (S)-3-hydroxy- di-trans,octa-cis- a [protein]- a nucleoside + synthase: sul synthase: sul S-adenosylhomocysteine using (R,S)AdoMet and using (R,S)AdoMet and using (R,S)AdoMet and synthase: dehydrogenase: carbamoyltransferase: γ A NADH H IPP GGPP synthase: menC L-cysteine synthase: dxs oxidase: thiO preuroporphyrinogen dehydrogenase: L-alanyl- -D-glutamyl-L- methylguanine L-cysteine an apurinic/ phosphate 6-phosphate octadecenoyl-CoA -glycerol an N-terminal dITP [acp domain riboflavin a thiocarboxylated- nucleosidase: mtnN methylenetetrahydrofolate methylenetetrahydrofolate methylenetetrahydrofolate bioI bdhA isobutanoyl-CoA a [glycine-cleavage 2-iminopropanoate (S)-(+)-allantoin undecaprenyl phosphate triphosphate GMP YneF coenzyme A biosynthesis NADPH-FMN (R,R)-2,3- phosphoglycerate fadN argF lysyl-D-alanyl-D-alanine in DNA apyrimidinic site nucleoside putative catabolic enoyl-CoA L-methionine within a fatty FlgL YqhV heme a 1-deoxy-D-xylulose [ThiS sulfur- 6 7,8- 7,8- 2-iminoacetate reductase [NAD(P)H]: yitJ reductase [NAD(P)H]: yitJ reductase [NAD(P)H]: yitJ oxidoreductase a pimeloyl-[acp] (2S,3S)-3- complex H protein] N carbamoyl phosphate hydratase / 3- deoxyinosine/ acid synthase]enoyl-acyl GMP 2-succinylbenzoate bifunctional protein CoaBC; 5-phosphate carrier protein] biotin biosynthesis II S-ribosyl-L- uroporphyrinogen butanediol mutase: pgm triphosphate 6-phospho- dihydropteroate dihydropteroate biosynthesis riboflavin kinase: ribC (nitroreductase): ycnD -[(R)-lipoyl]-L-lysine 6-phospho- putative NADH secreted deoxyxanthosine carrier reductase phosphopantothenoylcysteine homocysteine a 5-methyltetrahydrofolate a 5,10- III cosynthase: hemD hydroxy-2- phospho-N- DNA repair endonuclease pyrophosphatase; gluconate hydroxyacyl-CoA methionine heptaprenyl O-succinylbenzoic folyl- AIR thiamine diphosphate salvage IV (yeast) 8-amino-7- branched-chain carbamoyl phosphate beta- dehydrogenase: alkaliphilic triphosphate protein (NADP- folyl- synthetase/decarboxylase: coaBC thiazole methylenetetrahydrofolate NAD(P)H-flavin 2-phospho-D-glycerate methylbutanoyl- acetylmuramoyl- protein; 6-O- III: nth septum formation dehydrogenase dehydrogenase: aminopeptidase: diphosphate pyruvate acid-CoA protoheme pimelate oxononanoate (S)-3-hydroxy-isobutanoate alpha-keto acid synthetase: carA carB glucosidase: yutJ lipase: lip pyrophosphatase, reductase: dependent)pyruvate pyruvate polyglutamate polyglutamate FMN synthase: thiG oxidoreductase uroporphyrinogen-III CoA pentapeptide DNA-binding (NAD[+]- fadN mapA synthase: transporter YuiB ligase: menE a 5,10- heme o 4'-phosphopantetheine S-ribosylhomocysteine methylenetetrahydrofolate synthase: bioF dehydrogenase pyruvate methylguanine-DNA type IV apurinic/ licH a (2E)-tetracos- : guaC SivA synthase: folC synthase: folC phosphomethylpyrimidine 6-carboxyhexanoate- thiamine (nitroreductase): hypO glycine carbamoyl-phosphate protein (multicopy NADH dependent): yqeC secreted promiscuous hepT hepS fabI methenyltetrahydrofolate synthase: lyase: luxS dehydrogenase; enolase: eno undecaprenyl methyltransferase: apyrimidinic enoyl-CoA methionine 2-enoyl-[acp 4-(2'- FMN synthase: thiC 2-[(2R,5Z)-2-carboxy- CoA ligase: bioW (8S)-8-amino-7- E3 subunit decarboxylase: synthase (glutamine- aryl-6- dehydrogenase: esterase / (subunit A): ysnA IMP 7,8-dihydrofolate 7,8-dihydrofolate ctaB1 phosphopantetheine serine methenyltetrahydrofolate phosphate (C55P) radA endonuclease: associated 6-phosphogluconate hydratase: aminopeptidase domain within carboxyphenyl)- methylenetetrahydrofolate adenylyltransferase: heme b biosynthesis IV FMNH oxononanoate (dihydrolipoamide gcvPB gcvPA hydrolysing): ndh acylglycerol AppB monoglutamate monoglutamate 4-methylthiazol-5(2H)- pimeloyl-CoA hydroxymethyltransferase: glyA 2 filamentation): maf phospho-beta- fadB [+ 2 isozymes] all-trans- dehydrogenase; heme o adenylyltransferase: HMP-P thiaminase cyclohydrolase: folD transferase: mraY [+ 3 isozymes] nfo dehydrogenase B: mapB a fatty acid 4-oxobutyryl-CoA ribC ylidene]ethyl phosphate (Gram-positive bacteria) AI-2 phosphoenolpyruvate (S)-methylmalonate- 2-methylacetoacetyl- dehydrogenase) pyrAA pyrAB glucosidase: (S)-3-hydroxy-(9Z) lipase: estB SpoVM coaD L-homocysteine putative 5,6- putative NTP (NAD+- dIMP heptaprenyl synthase] 1,4- methenyltetrahydrofolate synthase: thiazole 8-amino-7- II: tenA 5-formyltetrahydrofolate CoA : lpdV a [glycine-cleavage bglA -octadecenoyl-CoA CwlJ 4-amino-2-methyl-5- dimethylbenzimidazole semialdehyde a [glycine-cleavage L-serine undecaprenyl-diphospho-N- dependent): gntZ diphosphate dihydroxy-2- cyclohydrolase: folD ctaB 3'-dephospho- FAD tautomerase: uroporphyrinogen-III oxononanoate a 5,10- cyclo-ligase: yqgN a (6S)-5- complex H protein] N 6 - carbamate UMP pyrophosphohydrolase: A(H2) NAD + phosphomethylpyrimidine cobalamin- a tetrahydrofolate Polyprenyl Biosynthesis pyruvate kinase: pyk [+ 2 isozymes]complex H protein] N 6 degradation γ a [protein]-S- a 3'-terminal a 5'-phospho- D-ribulose 10 synthase: yfhC acetylmuramoyl-L-alanyl- -D- a guanine in DNA mutT a 1,2-diacyl- naphthoyl- an N - ferroheme o CoA tenI uroporphyrinogen III synthase: bioF 4-amino-2-methyl-5- 5-(2-hydroxyethyl) methenyltetrahydrofolate formyltetrahydrofolate aminomethyldihydrolipoyl- methyl-L-cysteine unsaturated sugar [DNA] a fatty acid met a peptide YwtG a 7,8-dihydrofolate a 7,8-dihydrofolate kinase: thiD independent -dihydrolipoyl-L-lysine glutamyl-L-lysyl- D-alanyl-D-alanine a nucleoside 5'- β-D-glucose 5-phosphate sn-glycerol CoA formyltetrahydrofolate dephosphocoenzyme 2-(2-carboxy-4- decarboxylase: hemE (8S)-8-amino-7- pyrimidinemethanol -4-methylthiazole L-lysine salicyl alcohol YbcL heme a methionine 5,6-dimethylbenzimidazole trans, trans-farnesyl pyruvate ser monophosphate 6-phosphate (2E,6E)-farnesyl synthase: A kinase: coaE methylthiazol-5- coproporphyrinogen III oxononanoate phosphomethylpyrimidine hydroxyethylthiazole methylenetetrahydrofolate dihydrofolate synthase: HMP-PP synthase: metE formyltetrahydrofolate diphosphate biosynthesis propanoyl-CoA PgdS diphosphate menB dihydrofolate phosphoribosylglycinamide yl)ethyl phosphate kinase, 4-amino-5- (S)-3-amino-2- hydrogencarbonate acetyl-CoA L-cysteine L-serine reductase: dfrA ctaA L-lysine-8-amino- kinase: thiM dehydrogenase; CO bacillithiol biosynthesis coproporphyrinogen hydrolase: purU methylpropanoate 2 dehydratase: heptaprenyl 1,4-dihydroxy-2- reductase: dfrA formyltransferase: purN coenzyme A 7-oxononanoate hydroxymethyl-2- 4-methyl-5-(2- met methenyltetrahydrofolate heme b biosynthesis II degradation II lipid II (meso a 2'- an N-terminal 1-oleoyl-sn DNA combined KbaA III oxidase IPP sdaAB sdaAA a nascent peptidoglycan a long-chain fatty acyl- a [protein] (L-serine/L- a long-chain a [protein]-L- a [protein]-L- diphosphate naphthoyl-CoA ferroheme i thiamine-phosphate methylpyrimidine and 4- phosphooxyethyl) cyclohydrolase: folD aminomethyltransferase 2-aminoprop- deoxyribonucleoside an aminopeptidase a RNA-DNA hybrid H O butan-1-ol SwrB a tetrahydrofolate aminotransferase: (oxygen-independent) isopentenyl diaminopimelate containing) with (L-alanyl-γ-D-glutamyl- a malonyl-[acp] [DNA] L-alanyl-[S18 L-cystathionine fatty acyl-CoA 2 -glycerol 3- proline (ω = 180) with exogenous methionine (S)-malate UDP-N-acetyl- pyrophosphorylase (coproporphyrin- amino-5-hydroxymethyl- pyridoxal 5'-phosphate salvage I Macromolecule Modification [acyl-carrier protein] threonine) phosphate substrate synthase: a tetrahydrofolate bioK thiazole cys (glycine cleavage 2-enoate meso-2,6-diaminopimeloyl-D- 5'-triphosphate protein of phosphate NADH-dependent prolyl DNA to form a peptide α-D-glucosamine S-adenosylmethionine 10 diphosphate phosphoserine protein- NprB heme a di-trans,poly-cis-undecaprenyl (thiamine phosphate thiamine diphosphate forming): hemY 2-methylpyrimidine thiamine-phosphate an N - system protein T): gcvT putative ribosomal- 1-acylglycerol- hepT hepS (7R,8S)- synthetase: metK uroporphyrinogen-III isomerase: fni L-threonine cysteine alanyl-D-alanine) pentapeptide phosphatase: rsbP 30S ribosome] butanol isomerase recombinational methionine all-trans- lipoate biosynthesis and thioredoxin pathway synthase: phosphate biosynthesis synthase): thiE salvage III pyrophosphate kinase: thiD formyltetrahydrofolate ribonuclease protein-alanine N- acyl-CoA phosphate Holliday putative L- L-malate coproporphyrin III diaminononanoate pyrophosphorylase uroporphyrinogen III pyridoxal DMAPP queuosine L-glutamine degradation II desulfhydrase: L-asparagine beta-ketoacyl-acyl DNA cystathionine dehydrogenase: (trigger junction S-sulfoxide heptaprenyl 1,4-dihydroxy- incorporation III (Bacillus) ctaA lipoate peptidoglycan SpoIIAA- aminopeptidase HIII: rnhC thioesterase: (1-acyl-G3P) glutamine glycosyltransferase: (thiamine phosphate decarboxylase: hemE biosynthesis I (de novo) degradation I mccB degradation I acetyltransferase: gamma- yugJ factor): tig junction reductase: gln gln YphA (2E,6E)-farnesyl thiamine dethiobiotin HMP-P SAM folate polyglutamylation 2-aminoprop- glycosyltransferase carrier protein phosphate serine polymerase (Met-Xaa and acyltransferase: ABC diphosphate 2-naphthoate an oxidized acyl carrier salvage I synthase): thiE 2-iminopropanoate ribonuclease yjcK yneP resolvase: msrA hydroxyferroheme i bshA diphosphate thiamine phosphate coproporphyrin synthetase: coproporphyrinogen III thr 2-enoate (penicillin-binding synthase II phosphatase: spoIIE with 3'-5' Xaa-Pro, Xaa- lyase: mccB NADH-dependent peptidyl- resolution of a protein-L- transporter an octanoyl-[acp] undecaprenyl thiamine preQ L-arginine degradation III HII: rnhB promiscuous plsC recU Epr guanylyl molybdenum thioredoxin protein ferrochelatase: hemH 0 threonine 3- ribosomal protein (R)-lipoate pyrophosphokinase: bioD 4-amino-2-methyl-5- thiamine pyridoxamine gln asn proteins 1A (involved in pimelate multitarget exonuclease Pro-Xaa): papA butanol prolyl recombinational methionine- gln GlnT gln 1,4-dihydroxy- protein metabolism pyrophosphate thiamine- a tetrahydrofolate coproporphyrinogen 7-cyano-7- (arginine decarboxylase/ acyl-CoA putative 1-acyl- cofactor biosynthesis (S)-malyl N-acetyl- phosphomethylpyrimidine phosphate glutamyl-tRNA(Gln) dehydrogenase: L-asparaginase and 1B): ponA synthesis): fabF activity; phage S18 alanine N- dehydrogenase isomerase: junction (S)-S-oxide 2-naphthoate octanoyltransferase: lipoate- di-trans,octa-cissynthase: uppS thiN III oxidase: hemZ geranyl agmatinase pathway) phosphorylated protein aminopeptidase: thioesterase: sn-glycerol- YdeO MoO - a holo acyl- α-D-glucosaminide monophosphate thiamine Fe-coproporphyrin III dethiobiotin kinase: thiD pyridoxine pyridoxine, deazaguanine amidotransferase: tdh 2 (putative SPbeta: yorL acetyltransferase: 2-oxobutanoate subunit: yugK ppiB 2 protein phosphatase: prpC ampS a nucleoside 5'- cys formation of two heptaprenyltransferase: a [glycine-cleavagelipM Fur-regulated -undecaprenyl kinase: thiL diphosphate reductase: queF L-2-amino-3- a nascent peptidoglycan DNA an N-terminal N ykhA 3-phosphate a [protein]-L- molybdopterin carrier protein N-acetyl diphosphate folyl- serine coproporphyrinogen pyridoxine, pyridoxal, and gatC gatA gatB lipoprotein) di-trans,octa-cis- [+ 6 isozymes] monophosphate rimI 1-butanal intact strands YdbL menA complex H protein] NADPH:ferredoxin ferroheme a ligase: lplJ diphosphate coproheme III oxidative biotin HMP-PP pyridoxine preQ oxobutanoate 2-iminopropanoate arg pyruvate with (L-alanyl-γ-D-glutamyl- a [protein] Ser/Thr -acetyl-L-alanyl- acyltransferase: ω cofactor [(R)- polyglutamate hydroxymethyltransferase: glyA III oxidase: hemN pyridoxal, and pyridoxamine farnesyl 1 : ansZ L-alanine undecaprenyl diphosphate proline ( = 0) LytE 6 molybdopterin- hydrolase: undecaprenyl- carbamoyl-phosphate arginine meso-2,6-diaminopimeloyl-D- a long-chain 3-oxoacyl-[acp] N -octanoyl-L-lysine oxidoreductase: ycgT lipoyl]adenylate thiamine diphosphate decarboxylase: hemQ synthase: bioB kinase: pdxK kinase: pdxK diphosphate 2-amino-3- degradation IV [S18 protein of ypkP bshB2 synthase: folC 10 pyridoxamine a proteinogenic a long-chain GcvH:[lipoyl domain] guanine pyrophosphate thiamine an N - protoporphyrinogen IX tRNA-guanine synthase (glutamine- decarboxylase: exported L- alanyl-D-alanine) pentapeptide a peptide 30S ribosome] bisoleoyl YncC demethylmenaquinol-7 thioredoxin lipoate- synthase: ispA ketobutyrate amino acid amidotransferase: dinucleotide holo-acyl carrier N-acetyl phosphatase: harderoheme III 4,5-secobiotin a 5,10- formyltetrahydrofolate pyridoxine kinase: pdxK pyridoxamine transglycosylase: tgt hydrolysing): speA asparaginase: [DNA] fatty acid phosphatidate reductase: protein synthase protein thiamine methylenetetrahydrofolate (2E,6E)-farnesyl CoA ligase menaquinol lipL biosynthesis hydrolase: uppP a tetrahydrofolate folyl- 5'-phosphate 5'-phosphate a 7-aminomethyl-7- pyrAA pyrAB agmatine ansA ala 17099 trxB (phosphopantetheinyl ligase: lplJ pyrophosphokinase: diphosphate (glycine acetyl pyruvate protein A: mobA bshB1 coproheme III oxidative biotin folyl- polyglutamate deazaguanosine 34 [+ 8 isozymes] asp L-alanine Vpr methyltransferase: a [lipoyl-carrier protein] a [lipoyl-carrier undecaprenyl transferase) transferase): acpS thiN polyglutamate 967 6 6 α pyridoxal 5'-phosphate biosynthesis II decarboxylase: hemQ synthase: bioB synthase: folC in tRNA glu agmatinase: dehydrogenase lipid II (meso lipid II (meso a tRNA precursor a cytosine a (2E)-hexacos- menH N -octanoyl-L-lysine molybdopterin- protein]-N -[(R (S)-malyl -D- pyrophosphate : kbl an L-lysyl- ADP-D-ribose fructosevaline- acetyl-CoA YrpDX synthase: folC protoporphyrin IX a phosphatidylglycerol an alkylated DNA H O ATP stearoyl-CoA H O an acyl-CoA H O sec an epoxide acyl carrier thiamine 10 S-adenosylmethionine speB (NAD- Lys diaminopimelate diaminopimelate with a 5' 2 in 16S rRNA 2 2 ser a tRNA 2-enoyl-[acp lipoyl guanine a reduced )-lipoyl]-L-lysine glucosaminide phosphatase an N - [tRNA ] 6-phosphate menaquinol-7 protein activation protoheme biotin diphosphate a 5,10- dependent): ald containing) containing) extension and a RNA-binding acetyl-CoA domain within stress MotB dinucleotide thioredoxin cysteine- (bacitracin D-glyceraldehyde formyltetrahydrofolate tRNA gly synthase: lipA an apo acyl- S-adenosyl- aldehydo-D-ribose gln methylenetetrahydrofolate putrescine pyruvate short 3' extension Sun protein; 16S carboxylase a fatty acid induced biosynthesis adding resistance): bcrC PLP ribosyltransferase- L-glutamine L-glutamate degradation I putative ADP-ribose acyl-CoA enoyl-acyl SdpC a [lipoyl-carrier carrier protein an apo acyl- L-methionine 5-phosphate 3-phosphate putative DNA-3- flagellar-specific rRNA m5C967 fructosevaline- promiscuous subunit (biotin synthase] epoxide guanylylprotein B: mobB enzyme: bshC di-trans,octa-cis isomerase: queA degradation II L-aspartate phosphatidylglycerol peptidoglycan pyrophosphatase: seryl-tRNA YhfW protein]-N 6 -[(R)- biosynthesis methyladenine ATPase subunit 6-phosphate thioesterase: acyl-CoA carrier molybdenum carrier protein 34 degradation I lysyltransferase glycosyltransferase methyltransferase, carboxyl carrier hydrolase: holo-acyl carrier -undecaprenyl protoheme an epoxyqueuosine ribonuclease glycosylase: yfjP yjhB yneP thioesterase: synthetase: protein dihydrolipoyl]-L-lysine bacillithiol pyridoxal 5'- C1 Compound Utilization and Assimilation of export S-adenosyl- deglycase: frlB subunit): accB yfhM cofactor protein synthase phosphate in tRNA gln glu involved in tRNA- (penicillin-binding serS YwcA met phosphate P: rnpB rnpA DNA-3- apparatus: fliI L-methionine- ADP-ribose promiscuous ykhA a cerotoyl-reductase (phosphopantetheinyl glutamate cryptic glutamate asp dependent lysinylation proteins 1A pyrophosphatase: acetyl-CoA III: fabL a glycol S-adenosylmethionine synthase: epoxyqueuosine formaldehyde assimilation II (assimilatory RuMP Cycle) methyladenine ATPase: tsaE dependent: rsmB β acyl-CoA acyl-CoA [acp domain YxaL transferase): acpS synthase: dehydrogenase: gudB putative aspartate of phospholipids: mprF and 1B): ponA -D-glucose carboxylase: BdbB synthetase: metK pdxT pdxS reductase: queG glycosylase: alkA a 5-methylcytosine 967 nudF thioesterase: thioesterase: a holo acyl- gltB gltA a tRNA precursor 6-phosphate val accA accD an L-seryl- within a fatty glutamate aminotransferase: sec carrier protein SAM a queuosine 34 D-ribulose with a short a tRNA fragment in 16S rRNA ykhA yneP [tRNA ] acid synthase] glu dehydrogenase: rocG aspB F6P lipid II (meso di-trans,octa-cis + malonyl-CoA DtpT formaldehyde 5-phosphate 3-O-L-lysyl-1-O- a DNA containing ADP phosphate H D-ribofuranose PLP in tRNA 2-oxoglutarate oxaloacetate Lys -undecaprenyl 3' extension an alkylated phosphatidylglycerol a tRNA diaminopimelate AMP 5-phosphate glutaminyl-tRNA gln Aminoacyl-tRNA Charging 6-phosphofructokinase: nucleobase an apurinic/ FliD YtrH containing) diphosphate stearate a carboxylate biosynthesis via transamidation tRNA charging 3-hexulose- pfkA apyrimidinic site 6-phosphate β-D-fructose 1,6- YlbL 5-oxo-L-proline metabolism synthase Fatty Acid and Lipid Biosynthesis gln thr Thr a tRNA Tyr bisphosphate a peptide with N-acetyl-D- UDP-2,4,6- a [protein]-L- glu a tRNA tyr (HPS): hxlA an organic a 2,3,4-saturated an N-modified a ribonucleoside 5 34 YoaS Trp Phe Gly glyoxylate (S)-ureidoglycine a 2,3,4-saturated 2- H O a carboxylic ester a cytidine methylglyoxal (S)-benzoin trp a tRNA phe a tRNA gly a tRNA a [protein] with a [protein] with 2 an N-terminal galactosamine trideoxy-2- glutamate-O lys molecule YxkC fatty acyl-[acp] GTP aminoacyl-[tRNA] diphosphate Ile2 glutamyl-tRNA(Gln) ser Met Lys glu Cys Ile Pro Asn Ala asp His Val Leu Arg fructose-1,6- lysophosphatidate Xaa-L-proline 6-phosphate acetamido-4- -methyl-ester in tRNA general benzil anteiso-branched-chain fatty acid biosynthesis palmitate biosynthesis (type II fatty acid synthase) glutamyl- ser a tRNA elongator tRNA met lys a tRNA glu a tRNA cys a tRNA ile a tRNA pro a tRNA asn tRNA a tRNA ala tRNA asp his a tRNA val a tRNA leu a tRNA arg a tRNA an N-terminal an N-terminal ribonucleoside bifunctional even iso-branched-chain fatty acid biosynthesis odd iso-branched-chain fatty acid biosynthesis cis-vaccenate Gln Met met hexulose 6- bisphosphate UDP-2,4,6-trideoxy- CDP-diacylglycerol biosynthesis III amidotransferase: tRNA threonyl-tRNA tyrosyl-tRNA gln a tRNA initiator tRNA L-glutamine L-glutamate amino glucose reductase: P-450/ stress reductase CsbC biosynthesis gatC gatA gatB synthetase: thrS synthetase: tyrS Secondary Metabolite Degradation phosphate aldolase: fbaA (S)-ureidoglycine- carboxylesterase 2-acetamido-4- protein 18; (benzoin synthetase: tryptophanyl- phenylalanyl- glycyl-tRNA 1-acylglycerol- GTPase: dynA Xaa-Pro Xaa- peptidyl- N-acetylglucosamine- nrdE nrdF methyl-accepting tRNA(ile2) NADPH- ile 6-phospho-3- glyoxylate NP: nap amino glucose YmfD an acetoacetyl-[acp] val leu DHAP carbamoyl- gltX seryl-tRNA methionyl-tRNA lysyl-tRNA glutamyl-tRNA cysteinyl-tRNA tRNA isoleucyl-tRNA prolyl-tRNA asparaginyl-tRNA alanyl-tRNA aspartyl-tRNA histidyl-tRNA valyl-tRNA threonyl-tRNA tyrosyl-tRNA leucyl-tRNA arginyl-tRNA tRNA synthetase: synthetase: Pro-Xaa di-tri- tRNA 6-phosphate lysidine P450 deglycase: forming) D-glyceraldehyde aminotransferase phosphate ribosome- carboxylesterase: acetyltransferase: SPbeta phage chemotaxis YqgA a palmitoleoyl-[acp] phosphate synthetase: serS synthetase: metS synthetase: lysS synthetase: gltX synthetase: cysS synthetase: trpS synthetase: ileS synthetase: proS synthetase: asnS synthetase: alaS synthetase: aspS synthetase: hisS synthetase: valS synthetase: thrZ synthetase: tyrZ synthetase: leuS synthetase: argS pheT pheS glyS glyQ myo-, chiro- and scyllo-inositol degradation hexuloisomerase deacetylase: nagA reductase yfkM : yueD an acyl-[acyl- an L-glutamyl- 4-deoxy-L-threo-hex- D-sorbitol degradation I DHAP (PLP-dependent) (1-acyl-G3P) associated peptidase used in hydrolase: UDP-2,4,6- ribonucleoside- proteins (MCP) synthetase: isoleucine-valine beta-ketoacyl-acyl NAD(P)H- synthase a [protein] with (PHI): hxlB 3-phosphate yvaK epsM 1: yetO isoleucine-valine branched-chain Gln acyltransferase: GTPase: bipA osmoprotection: pth diphosphate -glutamate tilS glyoxalase benzil YyzG aminotransferase / carrier protein] [tRNA ] 4-enopyranuronate : pucG [+ 3 isozymes] trideoxy-2,4- carrier protein aminotransferase / amino acid dependent (glutamine- an L-methionyl- an L-methionyl- an N-terminal 5- papB [+ 2 isozymes] III: ydeA an (11Z)-3- ser Lys Glu Cys Trp Ile Pro Asn Ala asp His Val Thr Tyr Leu Arg Phe Gly Gln 1D-chiro-inositol degradation F6P plsC D-galactosamine diacetamido reductase: methylesterase: aromatic amino acid glutamyl-tRNA(Gln) an L-seryl-[tRNA ] Met an L-lysyl-[tRNA ] an L-glutamyl-[tRNA ] an L-cysteinyl-[tRNA ] an L-tryptophanyl-[tRNA ] an L-isoleucyl-[tRNA ] an L-prolyl-[tRNA ] an L-asparaginyl-[tRNA ] an L-alanyl-[tRNA ] an L-aspartyl-[tRNA ] an L-histidyl-[tRNA ] an L-valyl-[tRNA ] an L-threonyl-[tRNA ] an L-tyrosyl-[tRNA ] an L-leucyl-[tRNA ] an L-arginyl-[tRNA ] an L-phenylalanyl-[tRNA ] a glycyl-[tRNA ] an L-glutaminyl-[tRNA ] Met D-sorbitol transketolase: tkt SpoVAF reductase: fabG aromatic amino acid aminotransferase: ilvK phosphate:acyl- glycerol-3- hydrolysing): [elongator tRNA ] [initiator tRNA ] oxo-L-proline acetate oxooctadec- 4-deoxy-L-threo-hex- 6-phosphate glucose nrdFB nrdEB cheB 34 an alcohol (R)-lactate aminotransferase: amidotransferase: glucitol (sorbitol) GDP H + a 2'- a lysidine Bpr [+ 2 isozymes] aminotransferase: ilvE ACP phosphate pyrAA pyrAB 1D-chiro-inositol 1- 4-enopyranuronate N-carbamoyl- phosphate an N-modified an uncharged ilvE 11-enoyl-[acp] gatC gatA gatB γ-L-glutamyl dehydrogenase: a peptide with an alcohol a carboxylate deoxyribonucleoside in tRNA Ile2 4-methyl-2-oxopentanoate acyltransferase: dehydrogenase: [+ 7 isozymes] pyrrolidone- glutathione D-erythrose D-xylulose 2-oxoglycine gly a 2,3,4-saturated 1,2-diacyl- a proteinogenic amino acid tRNA branched-chain beta- a 5-phosphooxy- 5-phosphate dehydrogenase: iolG gutB an N-terminal α AimA branched-chain a (3R)-3-hydroxybutanoyl-[acp] plsX gpsA carboxylate 4-phosphate 5-phosphate sn-glycerol 3-phosphate amino acid 5'-diphosphate a [protein]- - amino acid ketoacyl- L-glutamyl- keto-D-fructose L-proline MeOH MltG amino acid branched-chain ammonium (pyroglutamate) scyllo-inositol 1-keto-D-chiro-inositol L-glutamate aminotransferase: ilvK acyl carrier sn-glycerol [tRNA Gln ] 5-dehydro-4-deoxy- formate aminotransferase: beta-hydroxyacyl- alpha-keto acid an acyl phosphate peptidase: pcp myo-inositol transaldolase: tal CwlO protein 3-phosphate peptidoglycan biosynthesis I (meso-diaminopimelate containing) Cell Structure Biosynthesis oxidation to CO ilvK [acyl carrier protein] dehydrogenase E2 D-glucuronate 2 3-methyl-2-oxobutanoate reductase: glutamyl-tRNA(Gln) type I lipoteichoic acid biosynthesis (S. aureus) teichuronic acid biosynthesis (B. subtilis 168) poly(3-O-β-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis scyllo-inosose a carboxy- a 2-oxo O-[-2-acetamido- (2E,7Z)- a glucosylated dehydratase: fabZ subunit (lipoamide scyllo-inositol 2- 4-deoxy-L-threo- a peptidoglycan S-methyl-L- a [lipoyl-carrier phosphoenol (S)-1-pyrroline- a [protein]- sn-glycerol OpuD (3S)-3-methyl-2- long-chain fatty UDP-N-acetyl- epimerase/ formate D-sedoheptulose D-glyceraldehyde adenylated- met L-homocysteine octanoate sulfite arg glycogenin acyltransferase) fabG acylphosphate:glycerol- amidotransferase: α 5-oxo-L-proline dehydrogenase myo-inositol 2- β cys carboxylate 3-O-(D-1- protein]-L-lysine hexadecenoyl-CoA pyruvate 5-carboxylate L-histidine a protein PbpD putative hydroxyacyl- branched-chain acid activation α -D- UDP-N-acetyl-α-D-glucosamine α 5-hexosulose- -D-fructofuranose putative formate 7-phosphate 3-phosphate formaldehyde methionine 3-phosphate 1,4-alpha- oxopentanoate [+ 2 isozymes] 3-phosphate O- gatC gatA gatB -D-glucosamine UDP-N-acetyl- -D-glucosamine (NAD+): iolX isomerase: iolI [ThiS sulfur- carboxyethyl)- enoyl-CoA 1-pyrroline-5- YxdK two- (acyl carrier protein) alpha-keto acid : bkdB glucopyranose dehydrogenase: iolG uronate ketol- oxidation V two-component sn-glycerol- a (3R,11Z)-3- UDP-N-acetylglucosamine 5-oxoprolinase: fructokinase: dehydrogenase: carrier protein] 2-deoxy-beta-D- hydratase / 3- carboxylate component glucan BslA branched-chain acyltransferase: plsY a long-chain 1-phosphate UDP-N- isomerase, (bacillithiol-dependent) N-acetylmuramoyl- 2-phospho-3- ATP-dependent 3-phosphate dehydratase: ycsD dehydrogenase E2 1-carboxyvinyltransferase: pxpB yrhE transketolase: tkt methionine- lipoate- hydroxyacyl-CoA dehydrogenase: sensory branching alpha-keto acid 3-methylbutanoyl-CoA hydroxyoctadec- fatty acid an L-glutaminyl- acetylglucosamine gmuE L-alanine glucopyranosyl]-2- homocysteine nitric-oxide protease (N- oxidase subunit (lipoamide putative UTP-glucose- pxpA pxpC scyllo-inosose 5-keto-4- CO protein sulfolactate enzyme: RodA dehydrogenase 11-enoyl-[acp] Gln murAA 4-epimerase: galE UDP-N-acetylglucosamine--undecaprenyl- 2 formaldehyde glutamine deoxy-D-glucose methylase dehydrogenase: putC synthase histidine kinase, YopI a (2E)-but-2-enoyl-[acp] acyltransferase) a 2-lysophosphatidate [tRNA ] 1-phosphate UDP-N- deoxyuronate amidase: cwlD cysteine ligase: lplJ synthase: yitD terminal serine (FAD- 5-methyl-3- beta- acyl-CoA phosphate N- F6P D-xylulose D-ribose 5- aminotransferase: fadN phosphorylated: glgB E2 subunit UDP-N-acetylglucosamine α acetylglucosamine isomerase: kduI [+ 9 isozymes] desulfurase: using (R,S) delta-1-pyrroline- (flavodoxin) protease) dependent) : bkdB oxohexanoyl-[acp] ligase: uridylyltransferase: UDP-N-acetyl- -D-galactosamine glu scyllo-inosose 5-phosphate phosphate mtnE yxdK (lipoamide enoyl-acyl hydroxyacyl- 1-acylglycerol- 1-carboxyvinyltransferase: 2-epimerase: mnaA acetylglucosaminephosphotransferase: tagO iscS AdoMet: ybgG enoyl-CoA 5 carboxylate : nosA : clpQ clpY : glpD a glycogen synthase: fabHB ydaB yngB dehydratase: iolE S-(hydroxymethyl) N-acetylmuramidase: a [lipoyl-carrier (2R)-phospho- ExlX acyltransferase) carrier protein isobutanoyl-CoA [acyl carrier phosphate murAB a 1,2-diacyl- 3-deoxy-D-glycero- hydratase: dehydrogenase: [+ 8 isozymes] bacillithiol ditrans,octacis- cwlT protein] N 6 - a [protein]- a peptide DHAP YcxB : bkdB 5-methyl-3- protein] a long-chain[+ 4 isozymes] α putative UTP- sn-glycerol 3D-(3,5/4)- 2,5-hexodiulosonate ribulose-5- D-ribose 5- a peptidoglycan 4-(methylsulfanyl) fadB 3-sulfolactate rocA YqgU reductase: fabI (1-acyl-G3P) UDP-N-acetyl- - undecaprenyldiphospho- a thiocarboxylated- a proteinogenic octanoyl-L-lysine N-phospho- 4-methyl-3- oxohexanoyl-[acp] dehydratase: fatty acyl-CoA glucose-1-phosphate trihydroxycyclohexane-1,2-dione 2-keto-3- phosphate 3- phosphate S-(hydroxymethyl) pentapeptide AMP -2-oxobutanoate (S)-3-hydroxy-(7Z) nitric oxide acyltransferase: Amine and D-glucosamine- putative α-D-GalNAc-PP-Und α lipid I N-acetyl-(N- ala [ThiS sulfur- amino acid met L-citrulline L-histidine (2S)-2-methylbutanoyl-CoA oxopentanoyl-[acp] synthase: fabHA fabZ uridylyltransferase: UDP-α-D-glucose UDP-N-acetyl- -D-mannosamine epimerase bacillithiol -hexadecenoyl-CoA glu a butanoyl-[acp] plsC enolpyruvate diacylglycerol Respiration respiration (anaerobic) 3D-(3,5/4)- deoxygluconate epimerase: carrier protein] N-acetyl-D- N-acetyl-D- Polyamine ytdA sn-glycerol 3-phosphate (promiscuous) dehydrogenase: acetylglucosaminyl)muramate SunA synthase: fabHB putative UDP-N- kinase: bmrU putative UDP-GalNAc:α-D-GalNAc- trihydroxycyclohexane- oxidoreductase: mannitol rpe glucosamine muramate 4-methyl-3- a 5-methyl-3-oxohexanoyl-[acp] Biosynthesis UDP-glucose 6- UDP-N- : ywlF adhA YoqO MscL beta-ketoacyl-acyl 4-methyl-3- hydroxyacyl- a phosphatidate acetylenolpyruvoylglucosamine UTP-glucose- diacylglycerol diphosphoundecaprenol α-1,6-N- 1,2-dione hydrolase: iolD kduD degradation I oxohexanoyl- putrescine dehydrogenase acetylmannosamine 2-phospho-D-glycerate carrier protein oxopentanoyl-[acp] (acyl carrier reductase: murB 1-phosphate kinase: dgkB acetylgalactosaminyltransferase: tuaG poly(glycerol phosphate) wall teichoic acid biosynthesis glycerol-3-phosphate 2-dehydro-3- D-mannitol S-formylbacillithiol [acp] synthase: beta-ketoacyl-acyl phosphatidate biosynthesis I (teichuronic transferase: tagA 5-deoxy-D-glucuronate cob(I)yrinate a,c-diamide- lipid II (meso a 2,3,4-saturated a hypoxanthine a [protein]- a double α synthase II synthase: fabHA ala uridylyltransferase: α-D-GalNAc-(1->6)-α- cytidylyltransferase: tagD ATP a D-aminoacyl- an N-acylated a (9Z)-3-oxooctacos- acetylxylan Ala ATP -amylose fabHB protein) UDP-N-acetyl- acid): tuaD deoxy-D-gluconate 1-phosphate diaminopimelate containing) 1,2-diacyl-sn- asp O-ureido-L- a glycyl-[tRNA ] L-tyrosine (involved in pimelate carrier protein cytidylyltransferase gtaB a phosphatidate α enolase: eno mannitol-1- [corrinoid adenosyltranferase] [tRNA] in DNA peptide 9-enoyl-[acp] stranded DNA dehydratase: α-D-muramate D-GalNAc-diphospho- UDP-N-acetyl- -D-glucosamine 2-keto-3- glycerol 3-phosphate CTP homoserine phosphate type-2 diadenylate 1,4-alpha- YqgT 4-methyl-3- reductase: fabG (CDP-diglyceride α β α CDP-glycerol 5-deoxy-D-glucuronate beta-ketoacyl- YwmF synthesis): fabF a 4-methyl-3-oxopentanoyl-[acp] ycsD arg ditrans,octacis-undecaprenol UDP- -D-glucuronate -D-ManNAc-(1->4)- -D-GlcNAc-PP-Und phosphate 5- protein-tyrosine- cyclase: cdaA glucan YxxF synthase): cdsA UDP-α-D-glucose phosphatidate isomerase: iolB deoxygluconate N-acetyl-β-D- acyl carrier promiscuous restriction oxohexanoyl- [+ 2 isozymes] a (2E,11Z)- arginine glu UDP-N- phosphoenolpyruvate dehydrogenase: putative hypoxanthine phosphatase: branching cytidylyltransferase kinase: kdgK phosphatidate putative protein gly-tRNA(Ala) enzyme diadenylate [acp] synthase: a 3-oxohexanoyl-[acp] beta-ketoacyl-acyl a CDP- decarboxylase: putative UDP-GlcA:α-D- 5-dehydro-2-deoxy-D-gluconate mtlD D-ribulose ATP:cob(I)alamin glucosaminidase: D-amino DNA argininosuccinate acetyl xylan yfkJ a (3R)-3-hydroxy-5- octadeca-2,11- acetyl (CDP-diglyceride UDP-N- UDP-N-acetylglucosamine--undecaprenyl- teichoic acid glycerol- formate BsuMI: ydjA cyclase: cdaS enzyme: fabHA carrier protein diacylglycerol glutamate GalNAc-(1,6)-α-D-GalNAc- F6P 5-phosphate adenosyltransferase: lytG cytidylyltransferase acyl-tRNA glycosylase: aag acylaminoacyl- reductase: fabG esterase- deacylase / D- methylhexanoyl-[acp] dienoyl-[acp] speA muramate- phosphate N- phosphate primase: tagB KDGP synthase: argG protein tyrosine- ydiS ydiR glgB beta-ketoacyl-acyl agmatine synthase): cdsA α acetylglucosamine (CDP-diglyceride deacylase: peptidase: yuxL [+ 2 isozymes] cephalosporin C Tyr-tRNATyr diadenylate FlgK BraB reductase: fabG enoyl-acyl racemase: alanine diphosphoundecaprenol - acetylglucosaminephosphotransferase: tagO pyruvate kinase: pyk 2-deoxy-5-keto-D- yvqK phosphatase: a double CapC a (4S)-4-methyl-3- beta-hydroxyacyl- cardiolipin biosynthesis I a 1,2-diacyl- 2-epimerase: mnaA synthase): cdsA a cis-delta9-3- deacetylase: cah deacylase: dtd cyclase: disA amylopectin carrier protein [+ 2 isozymes] carrier racE ligase: murC a CDP- 1,3-glucuronosyltransferase: Gro-P-β-D-ManNAc-(1->4) gluconic acid kinase: iolC undecaprenyldiphospho- yabD ptpZ stranded DNA oxohhexanoyl-[acp] [acyl carrier protein] 3-O-(β-D- GlcNAc an apurinic site hydroxyC28:1-[acp] reductase: fabG agmatinase: [+ 2 isozymes] diacylglycerol tuaC UDP-N-acetyl-α-D-galactosamine -α-D-GlcNAc-PP-Und 2-keto-3- N-acetylmuramoyl-L- a [protein]- with 5'-terminal c-di-AMP a (3R)-3-hydroxy-4- protein glucopyranosyl) oxaloacetate 5-dehydro-2-deoxy-D- adenosyl-cob(III) within DNA hypoxanthine canavaninosuccinate an N-acylated beta-ketoacyl- [+ 2 isozymes] dehydratase: fabZ a CDP-diacylglycerol speB UDP-N-acetyl- CDP-diacylglycerol- pyruvate deoxygluconate- a [corrinoid alanyl-γ-D-glutamyl-meso a peptide L-tyrosine phosphate methylpentanoyl-[acp] reductase: -sn-glycerol gluconate 6-phosphate triphosphate a CDP-2,3,4-saturated- an uncharged amino acid acyl carrier putative hydroxyacyl- CDP-diacylglycerol- α β-D-GlcA-(1->3)-α-D-GalNAc- α lipid I adenosyltransferase] yrinate a,c-diamide acetate xylan Ala PbpG fabI D-glt -D-muramoyl- glycerol-3-phosphate 3- UDP-N-acetyl- -D-mannosamine malate 6-phosphate -2,6-diaminopimeloyl- diacylglycerol a D-amino acid tRNA a tRNA gly GlcU TapA protein a (3R)-3-hydroxyhexanoyl-[acp] (acyl carrier protein) putrescine α beta-hydroxyacyl- glycerol-3-phosphate 3- L-alanine phosphatidyltransferase: (1->6)- -D-GalNAc-PP-Und sn-glycerol 3-phosphate dehydrogenase 2-deoxy-5-keto- aldolase: kdgA D-alanyl-D-alanine a cis- Aromatic Compound Biosynthesis reductase: fabG [acyl carrier protein] dehydratase: ycsD phosphatidyltransferase: pgsA putative UDP-GlcA:β-D- UDP-N- GalNAc-P-Gro-P-ManNAc- D-gluconic acid 6- vaccenoyl-[acp] UDP-α-D-glucose (NAD- [+ 2 isozymes] beta-hydroxyacyl- dehydratase: fabZ pgsA UDP-N- a 1,2-diacyl- α acetylmannosamine GlcNAc-PP-undecaprenol D-glyceraldehyde GlcA-(1,3)- -D-GalNAc- glycerol-3-phosphate dependent): mdh phosphate aldolase: iolJ pyruvate a [ThiI sulfur- molybdopterin a [prolipoprotein]- a (1->4)- a 3-oxohexacosanoyl- a peptide with type-1 a (1->4)- [acyl carrier protein] putative hydroxyacyl- a (2E)-5-methylhex-2-enoyl-[acp] a phosphatidylglycerophosphate acetylmuramoylalanyl-D- 3-O-[β-D- a phosphatidylglycerophosphate α transferase: tagA bacillibactin biosynthesis acetyl-CoA formate 3-phosphate a uracil in tRNA dihydrolipoamide an aminopeptidase a cis-delta21-3- RsiX a (4S,3R)-3-hydroxy- (1,6)- -D-GalNAc- cytidylyltransferase: tagD 3-(4-hydroxyphenyl) [+ 3 isozymes] carrier protein]-S- molybdate adenine S-1,2-diacyl-sn- α-D-glucan [acp domain within an N-terminal transmembrane a behenoyl-[acp] α-D-glucan YoaG SivC dehydratase: fabZ (acyl carrier protein) glutamate ligase: murD glucopyranosyl- β poly(glucosyl N- S substrate oxo-C40:1-[acp] XTP IMP 4-methylhexanoyl-[acp] diphosphoundecaprenol - pyruvate biosynthesis sulfanyl-L-cysteine acetoin dehydrogenase dinucleotide glyceryl-L-cysteine a fatty acid synthase] L-proline proteins 1,4-alpha- enoyl-acyl enoyl-acyl β phosphatidylglycerol acetylgalactosamine citrate 3-oxopropanoate beta-ketoacyl- beta-ketoacyl- putative enoyl-acyl putative hydroxyacyl- dehydratase: ycsD phosphatidylglycerol (1->6)-O- -D- 1,4-glucuronosyltransferase: β-D-ManNAc-(1->4)-α-D-GlcNAc-PP-Und CDP-glycerol chorismate (S)-malate DHAP Carbohydrate Degradation E2 component inosine/xanthosine 5' nucleotidase: glucan beta-hydroxyacyl- carrier protein carrier protein UDP-N-acetyl- 1-phosphate) synthase: mmgD glycogen acyl carrier acyl carrier rhomboid carrier (acyl carrier protein) cis-vaccenate phosphate (PGP) meso- glucopyranosyl]- phosphate (PGP) tuaH persulfide ATP (dihydrolipoamide molybdate to triphosphate yfkN branching [acyl carrier reductase III: fabL reductase: fabI α-D-muramoyl-L- tyr [+ 2 isozymes] signal double-zinc phosphorylase: protein protein putative proline protease: protein dehydratase: ycsD a (2E)-4-methylpent-2-enoyl-[acp] phosphatase; undecaprenyl- diaminopimelate sn-glycerol phosphatase; β β glucosyltransferase: ggaB isochorismate fumarate malonate-semialdehyde pyrophosphatase 5' nucleotidase, enzyme: SpoVAD alanyl-D-glutamate -D-GlcA-(1->4)- -D-GlcA- teichoic acid glycerol- tyrosine superpathway of glucose and xylose degradation pyrophosphatase acetyltransferase): acoC molybdopterin peptidase aminopeptidase: glgP reductase: fabG iminopeptidase: ydcA XhlB protein] pyrophosphate undecaprenyl- α CO H hydratase: fumC L-rhamnose degradation I reductase: fabG reductase: YwsB (1->3)- -D-GalNAc-(1->6) synthase citrate 2 2 dehydrogenase: mmsA involved in tRNA ligation (subunit A): ysnA promiscuous: glgB dehydratase: fabZ a (2E)-hex-2-enoyl-[acp] a 5-methylhexanoyl-[acp] phosphate primase: tagB Glc-GalNAc-P-Gro-P-ManNAc- aminotransferase: pyruvate dehydrogenase II: lspA ywaD [+ 2 isozymes] ybaC membrane fabI enoyl-acyl enoyl-acyl phosphatase (promiscuous pyrophosphate -α-D-GalNAc-PP-Und (siderophore- modification: thiI enzyme: moeA a (3R)-3-[+ 2 isozymes] [+ 2 isozymes] yutF UDP-N- GlcNAc-PP-undecaprenol 3-(4- hisC fumarate D-glucopyranose α (dihydrolipoamide α a cis-delta21-3- a (2E)-docos- starch putative carrier protein carrier protein activity): yodM phosphatase putative exporter specific): dhbC citrate hydro- -L- a (1->4)- -D- hydroxyhexacosanoyl- endopeptidase: beta-ketoacyl-acyl acetylmuramoylalanyl- a 1,2-diacyl- Gro-P-β-D-ManNAc-(1->4) hydroxyphenyl) acetyl-CoA 6-phosphate hydroxyC40:1-[acp] XMP inosine 2-enoyl-[acp] enoyl-acyl reductase III: fabL reductase: fabI (promiscuous rhamnopyranose acetyltransferase an (S-diacyl- a lipoprotein α-D-glucan glucopyranose [acp domain within glpG YczE hydroxyacyl-(acyl superpathway of fatty acid [+ 2 isozymes] D-glutamate-2, 6- 3-O-[β-D- involved in -α-D-GlcNAc-PP-Und lyase: citB MoO - a proteinogenic cleaved type-1 carrier protein carrier protein isochorismate pyruvate glucose-6- Entner-Doudoroff pathway I a [ThiI sulfur-carrier E2 subunit): pdhC 2 sn-glyceryl) a peptide 1-phosphate a peptide pro YgaD carrier protein) D-ala activity): yodM biosynthesis of L-rhamnose a 4-thiouracil in tRNA AMP molybdopterin signal peptide amino acid a fatty acid synthase] transmembrane LytF reductase: fabI synthase II biosynthesis initiation (E. coli) diaminopimelate glucopyranosyl- CDP- ribose protein]-L-cysteine -L-cysteinyl- dehydratase: a 5-methylhexanoyl-[acp] a phosphatidylglycerol [+ 2 isozymes] teichuronic acid: tuaB GalNAc-P-Glc-GalNAc-P-Gro-P- cis-aconitate phosphate 1- mutarotase: S-acetyldihydrolipoamide proteins (involved in pimelate ligase: murE (1->6)-O-β-D- glycerol:polyglycerol D-glucopyranose phosphorylation cofactor D-alanyl- β-D-GlcA-(1->4)-β-D-GlcA- ManNAc-GlcNAc-PP-undecaprenol isochorismatase: dehydrogenase: rhaM [apolipoprotein] ycsD acetyl-CoA glucopyranosyl]- a hexanoyl-[acp] beta-ketoacyl-acyl synthesis): fabF cardiolipin synthase: clsA a phosphatidylglycerol α phosphate glycero- dhbB D-threo-isocitrate succinate zwf 6-phosphate β-L- YrbF D-alanine UDP-N-acetyl- (1->3)- -D-GalNAc-(1->6) poly(glucosyl N- β-D-ribopyranose a (2E,4S)-4-methylhex- [+ 2 isozymes] sn-glycerol α phosphotransferase hydro-lyase: citB 6-phospho YojB carrier protein ligase α - -D-GalNAc-PP-Und acetylgalactosamine (2S,3S)-2,3-dihydroxy- glucose-6- rhamnopyranose cob(I)alamin- a 3-oxotetracosanoyl- beta-ketoacyl-acyl -D-muramoyl- D-ribose 6 6 lysine within [(R)- D-glucopyranose BdbA 2-enoyl-[acp] synthase II a 7-methyl-3-oxooctanoyl-[acp] acetyl-CoA (poly(glycerol D-glucono- ATP N ,N -dimethyl- succinyl-CoA a 3-oxoacid a [protein] Ser/Thr a cis-delta11-3- a 3-oxooctadecanoyl- a 3-oxopimeloyl- pyruvate beta- A: ddl L-alanyl-γ-D- putative polymerase 1-phosphate) gly 2,3-dihydrobenzoate phosphate 1- L-rhamnose pyranase: [corrinoid lipoyl]adenylate a 3-oxodocosanoyl-[acp] [acp domain within 6-phosphate an octanoyl-[acp] L-ornithine carrier protein carboxylase: Ptd Gro phosphate) D-threo-isocitrate 1,5-lactone L-arginine gcv protein H oxo-C30:1-[acp] [acp] [acp] methyl ester enoyl-acyl enoyl-acyl (involved in pimelate ketoacyl- 2 of teichuronic acid dehydrogenase: isomerase: adenosyltranferase] acetyl- synthase II beta-ketoacyl-acyl glutamyl-meso-2,6- polymerase): tagF glucosyltransferase: ggaB 2,3-dihydro-2,3- rbsD spore coat protein beta-ketoacyl- a fatty acid synthase]beta-ketoacyl- beta-ketoacyl- beta-ketoacyl- beta-ketoacyl- glycolytic enoyl-acyl carrier protein carrier protein synthesis): fabF acyl accA accD D-alanyl-D-alanine 6-phosphogluconolactonase: zwf amino acid MreD diaminopimelate repeating units: tuaE D-ala Glc-GalNAc-P-Glc-GalNAc-P-Gro-P- glycine- dihydroxybenzoate rhaA β-D-ribofuranose kinase: cotH acyl carrier and pentose phosphate (involved in pimelate carrier protein 1,2-diacyl-3-O- (Gro-P) -Gro-P-ManNAc- isocitrate 6-phospho lipoate- succinyl acyl carrier acyl carrier acyl carrier acyl carrier carrier YhcY reductase III: fabL reductase: fabI carrier a polyisoprenyl-wall teichuronic n [DhbF non- dehydrogenase: dhbA Aldehyde Degradation pgl putative putative protein phosphate generating racemase: synthesis): fabF reductase: fabG [6-O-(sn-glycerol GlcNAc-PP-undecaprenol ManNAc-GlcNAc-PP-undecaprenol dehydrogenase: icd keto-L-rhamnulose N(G),N(G)-dimethylarginine protein CoA:3- protein protein protein protein protein protein a 6-methyl-3-oxoheptanoyl-[acp] protein acid (B. subtilis 168) ribosomal D-gluconate D-glucono- ATP:cob(I)alamin pyruvate racX ComX [+ 2 isozymes] malonyl-CoA UDP-N- UDP-N-acetyl- phospho)-(β-D- D-alanine--[D- dimethylaminohydrolase: kinase: prkD reductase: fabG reductase: fabG reductase: fabG reductase: reductase: intermediates reductase a (4S)-4-methylhexanoyl-[acp] synthase UDP- 2,3-dihydroxybenzoate 1,5-lactone adenosyltransferase: ligase: lplJ oxoacid CoA- oxidase: a 3-oxooctanoyl-[acp] acetylmuramoylalanyl- α-D-glucosamine polyisoprenyl- alanyl carrier peptide 2-oxoglutarate methylglyoxal 6-phosphate ykgA serine/threonine- [+ 2 isozymes] [+ 2 isozymes] fabG fabG phosphatase: III: fabL D-ornithine beta-ketoacyl-acyl a (3R)-3-hydroxy-7- III 2: fabHB glucopyranosyl- glucose:polyglycerol methylglyoxal transferase: a (3R)-3-[+ 2 isozymes] ComGE malonyl protein] ligase: dltA synthase] + 6-phosphogluconolactonase: yvqK protein kinase: prkT a (3R)-3- a cis-delta11-3- araL ydaP a (2E)-oct- carrier protein D-glutamyl-2, 6- (1->6)-O-β-D- teichuronic acid- a polyisoprenyl-minor wall 2,3- degradation IV degradation IX NADP -dependent D-ribofuranose scoB scoA [+ 2 isozymes] [+ 2 isozymes] TlpB beta-ketoacyl- methyloctanoyl-[acp] CoA:acyl phosphate alpha- ligase: dhbF pgl a [glycine- hydroxytetracosanoyl- a (3R)-3- a (3R)-3- beta-ketoacyl-acyl diaminopimelate- glucopyranosyl) -peptidoglycan dihydroxybenzoate- 6-P-gluconate [+ 6 isozymes] hydroxydocosanoyl-[acp] hydroxyC30:1-[acp] D-glucopyranose acetyl phosphate 2-enoyl-[acp] acyl carrier reductase: fabG glucosyltransferase: tagE teichoic acid (B. subtilis 168) adenosylcob(III) AMP cleavage complex [acp domain within hydroxyoctadecanoyl- hydroxypimeloyl- carrier protein beta-hydroxyacyl- carrier protein D-alanyl-D-alanine teichuronic acid a D-alanyl-[D-alanyl carrier protein] bacillibactin methylglyoxal dehydrogenase: D-gluconate L-rhamnulofuranose ribokinase: dimethylamine a [protein] (L-serine/L- PhrH [+ 2 isozymes] N-acetyl-α-D- ]-sn-glycerol [DhbB aryl-carrier methylglyoxal L-citrulline 6 a fatty acid synthase] [acp] [acp] methyl ester protein synthase reductase: fabG [acyl carrier protein] an acetyl-[acp] transacylase: [(2-Glc)-Gro-P] -Gro-P-ManNAc- wall teichoic acid ABC rbsK alamin-[corrinoid triphosphate H protein] N -[(R ligase: murF transferase: tagT n synthetase: protein] ligase: dhbE methylglyoxal glyoxalase I; gndA 6-phosphate a 2,3,4-saturated threonine) phosphate II (involved glucosaminyl- GlcNAc-PP-undecaprenol transporter: tagH tagG 2-oxoglutarate decarboxylation to succinyl-CoA rhamnulokinase: adenosyltranferase] )-lipoyl]-L-lysine succinate YetK [+ 2 isozymes] a (3R)-3-hydroxy-6- dehydratase: fabZ fabD D-alanine carrier dhbF reductase: yvgN D-ribulose D-ribofuranose 3-oxoacyl-CoA YxkI in pimelate phospho- polyisoprenyl- bacillibactin hemithioacetal- rhaB methylheptanoyl-[acp] putative hydroxyacyl- malonyl-CoA- UDP-N-acetyl- wall teichoic acid ABC protein:PG D- a polyisoprenyl-minor wall (S)-lactaldehyde 5-phosphate 5-phosphate synthesis): fabF ditrans,octacis teichuronic acid- synthetase: a [2-oxoglutarate bacillithiol a (3R)-3-hydroxyoctanoyl-[acp] acyltransferase α-D-muramoyl- 1,2-diacyl-3-O- transporter: tagH tagG alanyltransferase: dltD teichoic acid (B. subtilis 168) (glycyl)adenylate L-rhamnulose beta-hydroxyacyl- (acyl carrier protein) -undecaprenol -peptidoglycan dhbF dehydrogenase E2 lactoyl-bacillithiol all-trans- WapA γ [6-O-(sn-glycerol thr 1-phosphate + a [protein]- 3-oxododecanoyl- an organic a (6S)-6-methyl-3- [acyl carrier protein] dehydratase: ycsD involved in L-alanyl- -D- [(2-Glc)-Gro-P] -Gro-P-ManNAc- 6 lactaldehyde coenzyme A [EntB aryl- H hydrogencarbonate acetoacetate succinyl-CoA a [protein]-L-lysine sn-glycerol a maltodextrin a cis-delta17-3- a (9Z)-3-oxohexadec- a 3-oxoglutaryl- a phosphate a decanoyl-[acyl- teichuronic acid n 2-O-D-alanyl-1-O-phosphatidylglycerol protein] N -lipoyl-L-lysine β formation: glxA ribulose-5- D-ribose 5- KDGP heptaprenyl LtaSB beta-hydroxyacyl- phospho) - (2,3-dihydroxybenzoyl) 2-oxoglutarate dehydrogenase: -D- L-glutamine CoA hydroperoxide pro oxooctanoyl-[acp] bacillaene glutamyl-meso-2,6- di-trans,octa-cis n GlcNAc-PP-undecaprenol glycine- carrier protein] 1-phosphate oxo-C36:1-[acp] 9-enoyl-[acp] [acp] methyl ester monoester carrier protein] SpoIIIAG dehydratase: fabZ transferase: tagU branched-chain galactopyranosyl- phosphate 3- phosphate diphosphate putative [acyl carrier protein] a (2E)-7-methyloct-2-enoyl-[acp] diaminopimeloyl- -undecaprenyl (sn-glycerol L-threonine- [DhbF non- adenylate dehydrogenase rhaEW L-rhamnulose beta-ketoacyl- beta-ketoacyl- beta-ketoacyl- alkaline enoyl-acyl putative hydroxyacyl- synthesis: pksC a peptidoglycan-minor wall teichoic alpha-keto acid epimerase: epimerase (1,4)-β-D-xylan degradation peroxiredoxin- amino acid beta-ketoacyl- dehydratase: fabZ α phospho)-(β-D- polyisoprenyl- [DhbF non- 2,3- (E1 subunit): odhA (1->3)-D- D-xylose 1-phosphate maltodextrin acyl carrier acyl carrier acyl carrier phosphatase carrier D-alanyl-D-alanine phosphate N-acetyl- -D- PG:teichoic acid D- acid complex (B. subtilis 168) ribosomal putative aldehyde rpe (promiscuous) 2-keto-3- carbonic succinyl CoA:3- protein-glutamine acetyl-CoA C- racemase: acyl carrier (acyl carrier protein) teichuronic acid- dehydrogenase galactopyranose holo-acyl carrier heptaprenylglyceryl- α-glucosidase: protein protein related III: phoB protein EfeB putative hydroxyacyl- enoyl-acyl enoyl-acyl a malonyl-[acp] glucosaminyl- glucopyranosyl- alanyltransferase: dltB ribosomal peptide dihydroxybenzoate- dehydrogenase: deoxygluconate- aldolase: anhydrase: ytiB oxoacid CoA- gamma- acyltransferase: protein racX protein dehydratase: ycsD -peptidoglycan E3 subunit methylglyoxalase; xylose : ywlF β protein synthase protein: ymaD YdbT (acyl carrier protein) carrier protein carrier protein phospho-N- phospho- (1->6)-O-β-D- peptide synthase] [DhbB aryl-carrier rhaEW a (1->4)- -D-xylan phosphate mdxL fadA reductase: fabG reductase: reductase: alkaline reductase (dihydrolipoamide aldY isomerase: D-xylulose 6-phosphate (phosphopantetheinyl putative carbonic transferase: glutamyltransferase YlxX reductase: fabG glucopyranosyl) teichuronic acid a polyisoprenyl-major wall synthase] protein] ligase: dhbE lactoylbacillithiol arabinoxylan synthase: pcrB [+ 2 isozymes] fabG fabG [+ 2 isozymes] III: fabL D-proline dehydratase: ycsD a (2E)-6-methylhept-2-enoyl-[acp] reductase III: fabL reductase: fabI acetylmuramoyl- ditrans,octacis D-ala ligase: dhbF xylA 5-phosphate D-ribose 5- aldolase: kdgA anhydrase: yvdA scoB scoA (transglutaminase): tgl phosphatase [+ 2 isozymes] beta- ]-sn-glycerol transferase: tagV teichoic acid (B. subtilis 168) ligase: dhbF dehydrogenase) (S)-lactate lyase: glxB arabinofuranohydrolase: transferase): acpS a cis-delta17-3- an alcohol a (2E)-dec- acetoacetyl- pentapeptide -undecaprenol bacillibactin bacillibactin phosphate DHAP a (3R,9Z)-3-[+ 2 isozymes] a (3R)-3-[+ 2 isozymes] A: phoA ketoacyl- : lpdV (S)-lactaldehyde xynD 3-heptaprenyl- D-glucopyranose maltose hydroxyC36:1-[acp] 2-enoyl-[acp] a (3R,6S)-3-hydroxy- a (2E)-oct-2-enoyl-[acp] a 7-methyloctanoyl-[acp] [acp] undecaprenyl D-alanine- a peptidoglycan-teichuronic polyisoprenyl- bacillibactin synthetase: synthetase: a [2-oxoglutarate (R)-lactate D-xylulose transketolase: tkt D-glyceraldehyde acetyl-CoA decanoyl-CoA hydroxyhexadec- hydroxyglutaryl- an alcohol NucB enoyl-acyl enoyl-acyl acyl carrier [+ 2 isozymes]a [2-oxoglutarate a protein with an YrdR 6-methyloctanoyl-[acp] phosphate acid complex (B. subtilis 168) major teichoic acid-- synthetase: dehydrogenase pyruvate endo-1,4-beta- a holo-[EntB aryl- acetoacetyl-CoA succinate sn-glycero- carrier protein carrier protein synthase: -[D-alanyl dhbF dhbF dehydrogenase E2 protein] 3-phosphate 3',5'-ADP CO H O N 6 -(γ-glutamyl)- 9-enoyl-[acp] [acp] methyl ester CysP enoyl-acyl protein 6 xylulose xylanase: xynA 2 2 1-phosphate beta-ketoacyl-acyl fabHA (C55P) carrier peptidoglycan teichoic dhbF 6 E2 protein] N -S- β carrier protein] beta-hydroxyacyl- reductase III: fabL reductase: fabI synthase a glycyl-[DhbF a 2,3-dihydroxybenzoyl- N -dihydrolipoyl-L-lysine kinase: D-sedoheptulose D-glyceraldehyde glyceraldehyde- a (1->4)- -D-xylan L-lysine crosslink carrier protein carrier protein transferase: mraY protein] acid transferase: tagV succinyldihydrolipoyl-L-lysine [acyl carrier II (involved 1,2-diacyl-3- non-ribosomal [DhbB aryl- pyruvate xylB 7-phosphate 3-phosphate 3-phosphate oligosaccharide reductase: fabI synthase II ligase: dltA (L-threonyl)adenylate protein] a 6-methylheptanoyl-[acp] in pimelate O-[6-O-(2-O- polyisoprenyl- peptide synthase] carrier protein] dehydrogenase xylan beta-1,4- SkfA SpoVAA (involved in pimelate undecaprenyldiphospho- a D-alanyl- D-xylulose a [DNA]-3'- a 5'-phospho- a [DNA]-3'- an [RNA]-3'- 3-oxooctanoyl- a supercoiled N-acetyl-α-D- major teichoic acid-- UDP-N-acetyl-α-D-muramoyl- + O-acetyl-L- a tripeptide a cis-delta19-3- a (7Z)-3-oxohexacos- glycerol 1- YtnM dehydratase: fabZ an octanoyl-[acp] synthesis) 5-phosphate (NAD-dependent, xylosidase: xynB D-alanyl-D-alanine NAD cys ribonucleoside- DHAP a stearoyl-[acp] lys beta-ketoacyl-acyl synthesis): fabF N-acetylmuramoyl-L- glucosamine-sn- [D-alanyl peptidoglycan teichoic L-threonine- 2,3-dihydroxybenzoyl- transaldolase: tal L-alanyl-γ-D-glutamyl-L-lysine hydroxyl [DNA] homoserine hydroxyl CoA oxo-C38:1-[acp] 7-enoyl-[acp] duplex DNA phosphate putative : fabF glycolytic): gapA 2',3'- NAD(P)H- replicative carrier protein alanyl-γ-D-glutamyl-meso glycerol phospho) carrier protein] acid transferase: tagU [DhbF non- [DhbB]:glycyl-[DhbB] 2,3- β-D-xylopyranose beta-ketoacyl- beta-ketoacyl- glycerol-3- enoyl-acyl hydroxyacyl-(acyl beta-ketoacyl-acyl D-erythrose cyclophosphateputative RNA dependent DNA amino acid synthase II a 9-methyl-3-oxodecanoyl-[acp] -2,6-diaminopimeloyl- -(sn-glycerol D-alanine carrier ribosomal dihydroxybenzoyltransferase: F6P acyl carrier acyl carrier phosphatase: carrier n polyisoprenyl- 2-oxoglutarate 13-DPG glycogen degradation I UDP-N- DNA ligase apurinic/ peptidase T acetyl-CoA C- racemase: YhdL carrier protein) carrier protein an acetoacetyl-[acp] 4-phosphate 2',3'-cyclic glycerol-3- helicase: (involved in pimelate D-alanyl-D-alanine phospho)-(β-D- protein:PG D- peptide dhbF dehydrogenase (NAD- γ apyrimidinic (tripeptidase) acyltransferase: protein protein ppaX protein YyaM XkdG dehydratase: synthase II beta-ketoacyl-acyl major teichoic acid-- acetylmuramoylalanyl- cystathionine - phosphodiesterase: phosphate dnaC racX synthesis): fabF UDP-N- glucopyranosyl- alanyltransferase: synthase] bacillibactin complex lactose degradation III dependent) endonuclease: : pepT fadA reductase: fabG reductase: glycerol-3- reductase: ycsD (involved in pimelate carrier protein peptidoglycan teichoic transketolase: tkt phosphoglycerate a glycogen D-glutamyl-2, 6- synthase: metI an [RNA]-3'-ytlP dehydrogenase: fatty acid elongation -- saturated acetylglucosamine- (1->6)-O-β-D- dltD ligase: dhbF [+ 2 isozymes] fabG [+ 4 isozymes] phosphatase: fabI D-lysine synthesis): fabF acid transferase: tagT synthetase: (dihydrolipoamide kinase: pgk diaminopimelate-D-alanyl- : ligA exoA ribunucleoside- a single reductase: fabG lactose a cis-delta19-3- [+ 2 isozymes] gpsA yhcW a (2E)-octadec- a (2E,6S)-6-methyloct- an 8-methyl-3-oxononanoyl-[acp] N-acetylmuramyl- glucopyranosyl) 2-O-D-alanyl-1-O- bacillibactin dhbF transsuccinylase, glycogen D-alanine ligase: murF a (3R,7Z)-3- stranded DNA YrzS [+ 2 isozymes] a peptidoglycan-major wall teichoic D-glyceraldehyde 3-phospho- 2'-phosphate hydroxyC38:1-[acp] sn-glycerol 2-enoyl-[acp] 2-enoyl-[acp] (pentapeptide) ]-sn-glycerol phosphatidylglycerol synthetase: E2 subunit): odhB short chain phosphorylase: a 2'- a proteinogenic a dipeptide acetyl-CoA hexanoyl-CoA hydroxyhexacos- glycerol PrsW Bsn a 3-oxodecanoyl-[acp] an acetoacetyl-[acp] acid complex (B. subtilis 168) 3-phosphate D-glycerate acetate a [DNA]-3'- 3-phosphate beta-ketoacyl-acyl a (3R)-3-hydroxy-9- pyrophosphoryl- dhbF a 2,3-dihydroxybenzoyl- beta-1,4-galacto- glgP AMP [DNA] NMN L-cystathionine amino acid 7-enoyl-[acp] enoyl-acyl enoyl-acyl glyceraldehyde- UDP-N-acetyl-α-D-muramoyl-L-alanyl- hydroxyl deoxyribonucleoside carrier protein methyldecanoyl-[acp] undecaprenol N- an L-threonyl-[DhbF glycyl-[DhbF dipicolinate biosynthesis oligosaccharides carrier protein carrier protein beta-ketoacyl-acyl 3-phosphate an α-limit dextrin γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine 5'-monophosphate reductase: fabG acetylglucosamine non-ribosomal non-ribosomal beta-galactosidase reductase III: fabL reductase: fabI carrier protein beta-hydroxyacyl- dehydrogenase YukB [+ 2 isozymes] transferase: murG peptide synthase] peptide synthase] 2-oxoisovalerate decarboxylation to isobutanoyl-CoA (beta-galacto- YwzA reductase: fabG [acyl carrier protein] type I 2-phospho- TasA lipid II (meso asp (NAD-dependent, a reduced α-maltose 6'- an α(1,5)- a [lipoyl-carrier (2R)-phospho- D-mannitol a [protein]- [+ 2 isozymes] dehydratase: fabZ lipoteichoic acid pyranoside D-glycerate cob(II)inamide ATP a cis,cis-delta11,29-3- acetyl-CoA a cis-delta13-3- a (5Z)-3-oxotetracos- a (6S)-6-methyloctanoyl-[acp] a (3R)-3-hydroxy-8- a 3-oxoacyl-[acp] Secondary Metabolite Biosynthesis aspartate kinase III: thrD a [BCAA dehydrogenase glycolytic): gapA ferredoxin [iron- L-arabinan (R)-lipoate butanoyl-CoA RNA a palmitoyl-[acp] diaminopimelate 2,3-dihydroxybenzoylglycyl[DhbB]:L- hydrolase): ganA NADP + H + phosphate protein]-L-lysine 3-sulfolactate 1-phosphate L-arginine methylnonanoyl-[acp] putative hydroxyacyl- aspartate kinase I: dapG E2 protein] N 6 β-D- hydroxy C48:2-[acp] oxo-C32:1-[acp] 5-enoyl-[acp] containing) threonyl-[DhbB] 2,3- enolase: a debranched sulfur] cluster beta-ketoacyl-acyl beta-ketoacyl- beta-ketoacyl- 2-phospho,3- glycolytic enoyl-acyl protein beta-ketoacyl- a (3R)-3-hydroxydecanoyl-[acp] (acyl carrier protein) -lipoyl-L-lysine branched-chain 13-DPG galactopyranose maltotetraose ComGB beta-hydroxyacyl- methylerythritol phosphate pathway II dihydroxybenzoylglycyltransferase: dhbF aspartate kinase II: lysC eno α-limit dextrin α carrier protein acyl carrier acyl carrier sulfolactate and pentose carrier arginine NhaC acyl carrier methylerythritol phosphate pathway I preQ biosynthesis branched-chain putative 6-phospho- -L- lipoate- acetyl-CoA C- [acyl carrier protein] dehydratase: ycsD kanosamine biosynthesis II bacilysin biosynthesis 0 tetrahydrotyrosine L-aspartyl-4-phosphate alpha-keto acid ribonuclease phosphatase phosphate kinase: beta-hydroxyacyl- bacillibactin phosphoenol + arabinofuranosidas: xsa reductase: fabG acyltransferase: protein protein protein Hag protein synthase putative 3- biosynthesis alpha-keto acid dehydrogenase ATP:cob(I)alamin ferredoxin--NADP alpha- protein [acyl carrier protein] dehydratase: fabZ D-glyceraldehyde synthetase: phosphoglycerate glycogen [+ 2 isozymes] reductase: fabG reductase: PH: rph (sporulation intermediates reductase mcsB II (involved pyruvate D-glyceraldehyde D-glucopyranose dehydrogenase pyruvate adenosyltransferase: reductase: yumC glucosidase: α-L- ligase: lplJ fadA a [protein]- a (2E)-9-methyldec-2-enoyl-[acp] oxoacyl-acyl- 3-phosphate pyruvate E1 subunit: bkdAB kinase: pgk a cis,cis-delta11,29- related): yitC phosphatase: ω dehydratase: fabZ putative hydroxyacyl- beta-ketoacyl- chorismate dhbF aspartate-semialdehyde phosphorylase: yvqK malA arabinofuranosidase: [+ 2 isozymes] fabG III: fabL N -phospho- YjkB in pimelate carrier protein 3-phosphate 6-phosphate GTP prephenate E2 subunit [+ 2 isozymes] pyruvate 3-oxo-C48:2-[acp] araL (acyl carrier protein) acyl carrier Carbohydrate Biosynthesis glucose-6- dehydrogenase: asd 3-phospho- glgP a cis-delta13-3- [+ 2 isozymes] (2R)-3-sulfolactate a (2E)-hexadec- L-arginine YhaH synthesis): fabF putative hydroxyacyl- enoyl-acyl enoyl-acyl prephenate (lipoamide kinase: pyk abfA a [lipoyl-carrier a (3R,5Z)-3- a nucleoside dehydratase: ycsD protein synthase reductase: yusR 1-deoxyxylulose- phosphate 3- chorismate mutase: aroH GTP a 2,3-dihydroxybenzoyl- D-glycerate an oxidized 3-oxohexanoyl- hydroxyC32:1-[acp] RNA D-mannitol 2-enoyl-[acp] (acyl carrier protein) carrier protein carrier protein 1-deoxyxylulose- decarboxylase: acyltransferase) protein]-N 6 -[(R hydroxytetracos- diphosphate an (8S)-8-methyl-3- II (involved [+ 2 isozymes] 5-phosphate dehydrogenase: chorismate mutase- cyclohydrolase glycyl-L-arginyl- ferredoxin [iron- D-glucopyranose D-glucopyranose CoA dehydratase: ycsD reductase III: fabL reductase: fabI gluconeogenesis I 5-phosphate bacA L-aspartate 4-semialdehyde : bkdB phosphoglycerate pyruvate adenosylcobinamide triphosphate NADPH an α(1,5)- α-L- )-lipoyl]-L-lysine 5-enoyl-[acp] oxodecanoyl-[acp] a (2E)-8-methylnon-2-enoyl-[acp] in pimelate gluconeogenesis I glycogen biosynthesis I (from ADP-D-Glucose) UDP-α-D-glucuronate synthase: dxs ntdC isozyme 3: aroA I: folEB dihydro-4- [DhbF non-ribosomal an [apo BCAA an [apo BCAA dehydrogenase D-galactose degradation I (Leloir pathway) α-D- sulfur] cluster 6-phosphate synthase: dxs 3-dehydro- 6 mutase: pgm maltotriose YdaK a 2,3,4-saturated [+ 3 isozymes]dehydrogenase E2 protein] N -S-[2- glucopyranose L-arabinan arabinofuranose a (2E)-dec-2-enoyl-[acp] a 9-methyldecanoyl- synthesis): fabF a (3R)-3-hydroxyacyl- biosynthesis (from GTP hydroxyphenylpyruvate peptide synthase] glycogen degradation II YjbE beta-ketoacyl- D-glucose 6- prephenate 4-hydroxy- 6 enoyl-acyl enoyl-acyl fatty acyl-[acp] [acyl-carrier protein]putative (S)-malate D-glucopyranose UDP-glucose) 1-deoxy-D-xylulose cyclohydrolase bacillibactin E2 protein] N - methylpropanoyl]dihydrolipoyl- 2-phospho- 1-phosphate acyl carrier [acyl-carrier protein] (S)-malate 1-deoxy-D-xylulose phosphate H HPP tetrahydrodipicolinate β-D-galactopyranose hydroxyacyl-(acyl 7,8- 2 dihydrolipoyl-L-lysine L-lysine D-glycerate guanosine 34 enoyl-acyl carrier protein carrier protein 6-phosphate UDP-α-D-glucose 5-phosphate 3-oxo-glucose-6- I: folEA synthase: a glycogen a methyl-esterified a 2-O-acetylated (1S,2R)-1- a negatively an adenine D-sorbitol protein beta-ketoacyl-acyl 5-phosphate prephenate dihydroneopterin isomerase: bacB synthase: dapA 2-oxoglutarate a cis,cis-delta19,37-3- a uracil in DNA a cis-delta15-3- a (6Z)-3-oxooctadec- carrier protein reductase III: fabL reductase: fabI carrier protein) 1-deoxy-D-xylulose- dhbF aldose 1- homogalacturonan D-ala rhamnogalacturonan I ser C-(indol-3- 2',3'-cyclic supercoiled DNA in tRNA 6-phosphate a hexanoyl-[acp] a D-amino acid reductase: fabG carrier protein alpha- UDP-glucose 6- 1-deoxy-D-xylulose- phosphate:glutamate decarboxylase: bacA enolase: hydroxy-C56:2-[acp] oxo-C34:1-[acp] 6-enoyl-[acp] YbfH dehydratase: 3'-triphosphate dihydro-4-hydroxyphenyl (2S,4S)-4-hydroxy-2,3,4,5- epimerase: galM maltose glycogen yl)glycerol monophosphate beta-ketoacyl-acyl DNA tRNA specific glycolytic YqgB reductase: fabI an 8-methylnonanoyl- phosphoglucomutase: dehydrogenase 5-phosphate aminotransferase: ntdA bacillibactin eno alpha- 2',3'-cyclic beta-ketoacyl- beta-ketoacyl- enoyl-acyl D-amino [+ 2 isozymes] synthase II ycsD 5-phosphate 3-[(4R)-4-hydroxycyclohexa- 6-carboxy-5,6,7,8- pyruvate isomer tetrahydrodipicolinate phosphorylase: 3-phosphate topoisomerase adenosine and pentose pgcA (teichuronic acid): tuaD reductoisomerase: dxr synthetase: α phosphoglucomutase: putative pectin rhamnogalacturonan phosphodiesterase: carrier protein uracil-DNA acyl carrier acyl carrier carrier acid [acyl-carrier protein] (involved in pimelate reductoisomerase: dxr D-kanosamine tetrahydropterin phosphoenol -D-galactopyranose glgP III: topB a (3R,8S)-3-hydroxy- a decanoyl-[acyl-carrier protein] beta-hydroxyacyl- α-D- 1,5-dien-1-yl]-2-oxopropanoate H HPP dhbF dipicolinate synthase: branched-chain pgcA lyase: ywoF acetylesterase: yesY yjcG reductase: fabG protein protein A34 phosphate protein oxidase: synthesis): fabF NAD- UDP-glucose 6-phosphate 2 pyruvate D-alanine tryptophan glycosylase: 8-methyldecanoyl-[acp] beta-ketoacyl-acyl [acyl carrier NADP- NAD- MEP 3-[(4R)-4- synthase: queD reductase: bacG spoVFB spoVFA alpha-keto acid reductase: fabG reductase: DNA deaminase: intermediates malate dependent NADP- glucopyranose dehydrogenase: ugd MEP an α-limit dextrin endo-pectin aminotransferase: dat rhamnogalacturonan 2',3'-cyclic-nucleotide [+ 2 isozymes] ung reductase yurR YpjC beta-ketoacyl-acyl carrier protein dependent dependent kanosamine- 6-carboxy-5,6,7,8- bacillibactin dehydrogenase pyruvate galactokinase: galK synthase: a cis,cis-delta19,37- topoisomerase tadA phosphatase: a 2-oxo YtzA protein] malic enzyme malate dependent 1-phosphate hydroxycyclohexa-1,5-dien- tetrahydro-4- dipicolinate D-glucopyranose acetylesterase: rhgT 2'-phosphodiesterase: [+ 2 isozymes] fabG III: fabL beta-hydroxyacyl- a 11-methyl-3-oxododecanoyl-[acp] dehydrogenase malic enzyme malic enzyme putative UDP-glucose 2-C-methyl-D- lyase: pelB trpA trpB a hypoxanthine carboxylate carrier protein synthase II dehydratase: fabZ dehydrogenase glucose-1-phosphate 6-phosphate 1-yl]-2-oxopropanoate tetrahydropterin E2 subunit kinase: pyk 3-oxo-C56:2-[acp] a cis-delta15-3- I: topA araL a (2E)-hex- [acyl carrier (NAD- (conversion malic enzyme dehydrogenase: ytcA 2-C-methyl-D- hydroxyphenylpyruvate yfkN a (3R,6Z)-3-[+ 2 isozymes] 34 in tRNAs synthase II (involved in pimelate (conversion (NAD- (conversion erythritol 4-phosphate phosphatase: isomerase: bacB 7-carboxy-7- (lipoamide α-D-galactose 1-phosphate UDP-α-D-glucose an apyrimidinic uracil hydroxyC34:1-[acp] a relaxed DNA D-sorbitol 2-enoyl-[acp] protein] beta-ketoacyl-acyl a 2,3,4-saturated enoyl-acyl a trans-2-enoyl- dependent): mdh of malate (conversion adenylyltransferase: UDP-α-D-glucuronate erythritol 4-phosphate phenylalanine glucose an oligosaccharide with a methyl-esterified a rhamnogalacturonan D-glyceraldehyde 3'-GMP hydroxyoctadec- (involved in pimelate synthesis): fabF of malate dependent): mdh of malate cytidylyltransferase, ntdB deazaguanine acyltransferase) pyruvate D-glt pyruvate site in DNA dehydratase: fabZ carrier protein fatty acyl-[acp] carrier protein [acyl-carrier protein] into pyruvate) of malate glgD glgC cytidylyltransferase, 3-[(1E,4R)-4-hydroxycyclohex- a debranched 4-deoxy-6-O-methyl-α- homogalacturonan acetate type I 3-phosphate trp 6-enoyl-[acp] PbpX synthesis): fabF [+ 3 isozymes] into pyruvate, into pyruvate) nonmevalonate synthase: queE aminotransferase : bkdB kinase: YyzH reductase: fabG reductase III: fabL : maeA [+ 3 isozymes] into pyruvate, a (1->4)- nonmevalonate 2-en-1-ylidene]-2-oxopropanoate α-limit dextrin putative a 1o-methyl-3-oxoundecanoyl-[acp] anabolic): ytsJ : maeA ADP-α-D-glucose isoprenoid kanosamine forming glcK D-galact-4-enuronate end anabolic): ytsJ α-D-glucan isoprenoid 7-carboxy-7- L-lactate hydroxyacyl-(acyl a 3-oxododecanoyl-[acp] [+ 2 isozymes] [+ 2 isozymes] glycogen UDP-N-acetyl-D- pathway: ispD tetrahydrotyrosine [+ 2 isozymes] pathway: ispD deazaguanine dehydrogenase: ldh glycogen carrier protein) beta-ketoacyl-acyl a (3R)-3-hydroxy-11- enoyl-acyl (starch) galactosamine 4-(cytidine 5'- in bacilysin 6 a 3-O-acetylated (S)-3- 4-(cytidine 5'- 3-[(2E,5R)-5-hydroxy-7- phosphorylase: N -(3-methylbut-2-en-1- a single- a cis,cis-delta21,39- a long-chain D-gluconate Zn 2+ ABC dehydratase: beta-ketoacyl-acyl carrier protein 3-[(2E,5R)-5-hydroxy-7- 7-cyano-7- synthesis: bacF a peptide with a acetyl-CoA octanoyl-CoA 2+ 2+ YdzM methyldodecanoyl-[acp] carrier protein synthase: biosynthesis I diphospho)-2-C- (R)-lactate a sulfurated [sulfur carrier] yl)-adenosine 37 in tRNA a tRNA precursor rhamnogalacturonan I stranded RNA hydroxyhexanoyl- fatty aldehyde a protein an arachidoyl-[acp] a myristoyl-[acp] D-lysine Zn Zn diphospho)-2-C- oxabicyclo[4.1.0]heptan-2- deazaguanine D-glucopyranose glgP ATP leader sequence 3-hydroxyC58:2-[acp] transporter ycsD carrier protein reductase: fabG reductase: fabI glgA UDP-N-acetyl- methyl-D-erythritol oxabicyclo[4.1.0]heptan-2- (S)-lactate D-glucopyranose CTP CoA putative 2- beta-hydroxyacyl- a (1->4)- UDP-α-D-glucose biosynthesis α methyl-D-erythritol ylidene]-2-oxopropanoate 6-phosphate beta-ketoacyl-acyl enoyl-CoA extracellular enoyl-acyl enoyl-acyl D-amino reductase: fabG [+ 2 isozymes] -D-glucosamine 4-(cytidine 5'- ylidene]-2-oxopropanoate synthetase: tetrahydrotyrosine glycolysis II (from fructose 6-phosphate) Glycolysis ketogluconate Co 2+ Co 2+ a (2E,8S)-8-methyldec- α UDP-N- isomerase: bacB α-D- carrier protein neutral carrier carrier [acyl carrier protein] oxaloacetate -D-glucan 4-(cytidine 5'- queC rhamnogalacturonan polynucleotide acetyl-CoA C- hydratase / 3- putative alkanal acid 2+ 2+ [+ 2 isozymes] oxaloacetate diphospho) reductase; Zn CadA Zn 2-enoyl-[acp] a (3R)-3-hydroxy-10- dehydratase: fabZ pyruvate acetylglucosamine diphospho) glucopyranose enzyme for ms(2)i(6) acetylesterase: yesY signal peptide phosphorylase reductase: fabG acyltransferase: hydroxyacyl-CoA monooxygenase: metalloprotease: protein protein oxidase: YhcE pyruvate 1,4-alpha- D-glucopyranose 6-phosphate -2-C-methyl- glucose tRNA hydroxypyruvate Cd 2+ Cd 2+ methylundecanoyl-[acp] 4-epimerase:α galE -2-C-methyl- 3-[(2Z,5R)-5-hydroxy-7- preQ fructose 1,6- F6P 1-phosphate A formation for tRNA peptidase: sppA [+ 2 isozymes] dehydrogenase: nprE reductase: reductase yurR enoyl-acyl enoyl-acyl a (3R)-3-hydroxydodecanoyl-[acp] putative hydroxyacyl- glucan UDP-N-acetyl- - D-erythritol 0 kinase: nucleotidyltransferase: cca rhamnogalacturonan (PNPase): pnpA fadA yddN / glyoxylate phosphoenolpyruvate alpha- oxabicyclo[4.1.0]heptan-2- a cis,cis-delta21,39- 6-amino-2- 2+ 2+ phosphoenolpyruvate D-galactosamine D-erythritol bisphosphatase modification: ymcB acetylesterase: rhgT [+ 5 isozymes] fadN a peptide fabI III: fabL Mn MneS Mn carrier protein carrier protein beta-hydroxyacyl- (acyl carrier protein) carboxykinase: pckA branching kinase: ispE 3-[(2E,5R)-5-hydroxy-7- D-mannose degradation I alpha- glcK 3-oxo-C58:2-[acp] 3-oxohexanoyl- reductase: yvcT oxohexanoate carboxykinase: pckA phosphoglucomutase: pgcA kinase: ispE ylidene]-2-oxopropanoate class II: glpX 6-phosphofructokinase: a (2E)-icos- a (2E)-tetradec- reductase III: fabL reductase: fabI beta-hydroxyacyl- [acyl carrier protein] dehydratase: ycsD enzyme: α 2-phospho-4-(cytidine oxabicyclo[4.1.0]heptan-2- 2-keto-D- -D-glucopyranose 1-phosphate pfkA phosphoglucomutase: 6 a tRNA a nucleoside a single- 3-oxodecanoyl- CoA ν a long-chain 2-enoyl-[acp] 2-enoyl-[acp] 2-phospho-4-(cytidine N -(3-methylbut-2-en- a rhamnogalacturonan h 2+ 2+ YdgK [acyl carrier protein] dehydratase: fabZ glgB 5'-diphospho)-2-C- ylidene]-2-oxopropanoate fructose-1,6- putative D-mannopyranose pgcA stranded RNA CoA fatty acid gluconate Mn MneP Mn an (8S)-8-methyldecanoyl- phosphoenolpyruvate 5'-diphospho)-2-C- 3-[(2Z,5R)-5-hydroxy-7- β-D-fructose 1,6- 5'-deoxyadenosine 1-yl)-2-(methylsulfanyl) met an unsulfurated [sulfur carrier] containing a acetate diphosphate dehydratase: fabZ a (2E)-11-methyldodec-2-enoyl-[acp] phosphoenolpyruvate UTP-glucose-1-phosphate methyl-D-erythritol reductase: bacG bisphosphatase: fbp galactose-1- phosphotransferase type I a leader sequence a peptide putative hydroxyacyl- oxabicyclo[4.1.0]heptan-2- UDP-glucose 37 3' CCA end [acyl-carrier protein] UDP-N-acetyl-D- a glycogen methyl-D-erythritol bisphosphate phosphate adenosine in tRNA putative hydroxyacyl- (acyl carrier protein) uridylyltransferase: yngB 2-C-methyl-D- ylidene]-2-oxopropanoate fructose-1,6- epimerase: ytcB system (PTS) Mn 2+ ABC enoyl-acyl enoyl-acyl glucosamine biosynthesis I 2-C-methyl-D- autoinducer AI-2 biosynthesis I uridylyltransferase: Mn 2+ Mn 2+ beta-ketoacyl- (acyl carrier protein) dehydratase: ycsD enolase: eno putative UTP- erythritol-2,4- reductase: bacG bisphosphate mannose-specific transporter carrier protein carrier protein enolase: eno erythritol-2,4- UDP-glucose 4- YdiL acyl carrier D-glucopyranose glucose-1-phosphate cyclodiphosphate galT enzyme IIBCA RNase III mRNA peptidoglycan (S)-3- acetylated dehydratase: ycsD cyclodiphosphate aldolase: fbaA epimerase: galE a glycogen a cis,cis-delta17,29- reductase III: fabL reductase: fabI 6-phosphate synthase: ispF α-D-glucopyranose 1-phosphate UDP-α-D-galactose component: manP a 5-L-glutamyl- 2,3- a cytosine in DNA scyllo-inositol Ca 2+ ChaA 2+ protein synthase a (2E)-10-methylundec-2-enoyl-[acp] 2-phospho-D-glycerate uridylyltransferase: ytdA synthase: ispF 3-[(2S,5R)-5-hydroxy-7- SAM pyruvate fermentation Fermentation DHAP D-glucopyranose an amino acid gly thr processing DAP-DAP hydroxydecanoyl- homogalacturonan a protein a dodecanoyl-[acp] a butanoyl-[acp] D-serine Ca 2-phospho-D-glycerate glucose-6- phe D-mannopyranose [peptide] 3-hydroxyC48:2-[acp] II (involved a (2E)-dodec-2-enoyl-[acp] UTP-glucose-1-phosphate 2-C-methyl-D-erythritol- oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoate to butanoate 6-phosphate dihydroxybenzoate substrate crosslink beta-ketoacyl-acyl DNA- CoA scyllo-inositol an 11-methyldodecanoyl-[acp] phosphate 6-phosphate enoyl-CoA class III heat- enoyl-acyl enoyl-acyl D-serine in pimelate enoyl-acyl enoyl-acyl 2-C-methyl-D-erythritol- methyltransferase dehydrogenase 2+ 2+ phosphoglycerate isomerase: pgi uridylyltransferase: gtaB 2,4-cyclodiphosphate alpha- glycogen carrier protein hydratase / 3- pectin shock ATP- carrier carrier ammonia- Ca YetJ Ca synthesis): fabF enoyl-acyl carrier protein carrier protein phosphoglycerate 2,4-cyclodiphosphate triose mannose-6 (cytosine-specific) (NADP + ): iolU YhaR mutase: pgm F6P 3-[(2S,5R)-5-hydroxy-7- pyruvate phosphoglucomutase: bacillibactin murein L,D- phosphorylase: reductase: fabG hydroxyacyl-CoA acetylesterase: dependent LonA protein protein lyase: carrier protein beta-ketoacyl-acyl mutase: pgm UDP-α-D-glucose 4-hydroxy- SAH phosphate phosphate membrane bound gamma- ribonuclease reductase III: fabL reductase: fabI rhamnogalacturonan type ; defective scyllo-inositol + + a (10S)-10-methyl-3- carrier protein oxabicyclo[4.1.0]heptan- pgcA synthetase: endopeptidase: glgP [+ 2 isozymes] dehydrogenase: yxiM protease: lonA reductase reductase dsdA K KhtU K reductase: fabI 3-phospho-D-glycerate L-glutamine- 3-methylbut- isomerase: isomerase; cupin glutamyltranspeptidase: ggt III: rnc prophage 3: ydiP oxododecanoyl-[acp] 2-yl]-2-oxopropanoate I degradation II (bacteria) sucrose degradation I dhbF cwlK a cis,cis-delta17,29- fadN dehydrogenase III: fabL III: fabL synthase II 3-phospho-D-glycerate 2-en-1-yl S-adenosylhomocysteine tpiA family: manA a peptide pyruvate ferric iron an 10-methylundecanoyl-[acp] D-fructose-6- (E)-4-hydroxy-3- aminotransferase: bacF acetyl-CoA D-glucopyranose 6-phosphate (sucrose phosphotransferase) 3-oxo-C48:2-[acp] [+ 2 isozymes] 3-oxodecanoyl- (NADP+): iolW a (2E)-dodec- a (2E)-but- 3+ 3+ (involved in pimelate pulcherrimin α-D- K + KtrD K + Fe Fe beta-ketoacyl- a dodecanoyl-[acp] phosphoglycerate phosphate diphosphate nucleosidase: mtnN a rhamnogalacturonan type I an α-(5-L- RNase III maltotetraose a 5-methylcytosine CoA a pectate 2-enoyl-[acp] 2-enoyl-[acp] transporter synthesis): fabF phosphoglycerate fructan biosynthesis methylbut-2-en- biosynthesis mannose-6- peptidoglycan peptidoglycan glucopyranose acetate scyllo-inosose acyl carrier beta-ketoacyl-acyl kinase: pgk amidotransferase: synthase (1- D-glyceraldehyde sucrose glutamyl)- an mRNA fragment in DNA kinase: pgk 1-yl diphosphate degradative phosphate a peptide bacillibactin processing tetrapeptide, tripeptide, 1-phosphate protein carrier protein hydroxy-2- 3-phosphate rhamnogalacturonan + L-cystine a 13-methyl-3- glmS L-dihydroanticapsin S-ribosyl-L-homocysteine acetoacetyl- isomerase amino acid product mRNA glycan chain 2 glycan chain 1 Na ABC beta-ketoacyl-acyl sucrose Leu endolyase: yesW phosphotransferase L-cystine ABC L-cystine reductase: fabG synthase II oxotetradecanoyl-[acp] 13-DPG D-glucosamine methyl-2-(E) 1-hydroxy-2- an L-leucyl-[tRNA ] CoA thiolase: glyceraldehyde- Na + efflux Na + carrier protein 13-DPG α (active on aldose system (PTS) sucrose- transporter [+ 2 isozymes] (involved in pimelate -butenyl 4- methyl-2-(E) 3-phosphate 2-deoxy-α-D-ribose 1- 4-deoxy-4,5-unsaturated - transporter beta-ketoacyl-acyl 6-phosphate cyclodipeptide dihydroanticapsin 7- S-ribosylhomocysteine mmgA substrates with specific enzyme IIBC synthase II synthesis): fabF glyceraldehyde- levansucrase: diphosphate -butenyl 4- dehydrogenase phosphate degradation D-galactopyranosyluronate- a 2-oxo a long-linear (S)-3- α β-L-galactose ferric a (3R,10S)-3-hydroxy-10- laurate glyceraldehyde- phosphoglucosamine synthase: yvmC dehydrogenase: bacC lyase: luxS acetyl-CoA C- hydroxyl groups a [protein] N-terminal- a cis,cis-delta17,35- 2,5- a [protein]- - an acyl-[acyl- a [protein]- Na + :H + iron(III) iron(III) (involved in pimelate carrier protein sacB synthase) [rhamnogalacturonan component: sacP D-cellobiose 6'-phosphate L-ornithine glu a (6S)-5- α-D-glucan hydroxyoctanoyl- + + citrate ABC 3-phosphate diphosphate cyclo(L-leucyl-L-leucyl) (NAD-dependent, α carboxylate formyl-L-methionine dioxopentanoate L-glutamate 1-phosphate cys met L-threonine Na Na methyldodecanoyl-[acp] reductase: fabG 3-phosphate mutase: glmM 1-hydroxy-2- acetyltransferase: 2-deoxy- -D- oriented in the G 3-hydroxyC54:2-[acp] carrier protein] antiporter dicitrate dicitrate synthesis): fabF a 12-methyl-3-oxotridecanoyl-[acp] dehydrogenase : ispG reductase: glycolytic): gapA I oligosaccharide] sucrose 6 formyltetrahydrofolate beta-ketoacyl-acyl 2,5-dioxovalerate CoA methyl-accepting glycolytic transporter long chain acyl- triose dehydrogenase 1-kestotriose AI-2 yhfS ribose 1-phosphate same direction enoyl-CoA free enoyl-acyl protein beta-hydroxyacyl- [+ 2 isozymes] phosphoglucosamine methyl-2-(E) cyclo-L-leucyl-L- L-anticapsin ala -phosphate chemotaxis cysteine CoA ligase triose (NADP-dependent, 6-kestotriose (E)-4-hydroxy-3- ispH rhamnogalacturonan glycogen carrier protein dehydrogenase hydratase / 3- and pentose methionine- carrier kinase: + CopA Cu + phosphate (NAD-dependent, mutase: pgcA -butenyl 4- at the C-2 and C- 6-phospho-beta- peptide dioxygenase: Cu [acyl carrier beta-ketoacyl-acyl a (3R)-3-hydroxy-13- phosphate gluconeogenesis) methylbut-2-en- leucyl dipeptide acetoacetyl-CoA 13-DPG 1,5-phosphopentomutase: ornithine folyl- reductase: fabG (alpha-ketoglutaric proteins (MCPs) phosphate tsaE (degradative): lcfA isomerase: glycolytic): gapA α exolyase: yesX 3 positions as in glucosidase: licH deformylase: defA phosphorylase: hydroxyacyl-CoA (R)-sulfoxide protein YorM protein] a 3-oxotetradecanoyl-[acp] carrier protein -D-glucosamine levansucrase: 1-yl diphosphate diphosphate oxidase: cypX drm sucrose-6- aminotransferase: semialdehyde methyltransferase: intermediates cdoA a [protein] methyltetradecanoyl-[acp] isomerase: : gapB β polyglutamate glgP [+ 2 isozymes] dehydrogenase: reductase: 2+ 2+ [+ 4 isozymes] tpiA 1-phosphate IPP L-alanine-anticapsin 2-O-(4-deoxy- -L-threo- mannose): yvyI formylmethionine reductase: Mg MgtE Mg dehydratase: fabZ reductase: fabG tpiA D-glyceraldehyde sacB reductase: enoyl-CoA 2-deoxy-D-ribose phosphate aryl-6-phospho-beta- rocD synthase: folC a cis,cis-delta17,35- dehydrogenase) cheR phosphatase: L-threonine beta-hydroxyacyl- D-glyceraldehyde DHAP 1-hydroxy-2- ligase: bacD (2R,4S)-2-methyl-2,4- phosphoglycerate hex-4-enopyranuronosyl) fadN a [protein]-L- 3-sulfino-L-alanine ytsP a trans-2-fabI beta-ketoacyl-acyl lauroyl-CoA [+ 2 isozymes] DHAP 3-phosphate glucosamine-1- ispH pulcherriminic acid hydratase / 3- hydrolase: glucosidase: bglA deformylase A: defB phosphate kinase: pgk 5-phosphate α 3-oxo-C54:2-[acp] : ycbD 3-oxooctanoyl- 5 araL L-methionine- putative carrier protein [acyl carrier protein] 3-phosphate 1,1-kestotetraose neokestose methyl-2-(E) dihydroxydihydrofuran-3-one - -L-rhamnopyranose F6P α-D- a long-linear glutamate-O enoyl-[acyl- phosphate N- isopentenyl hydroxyacyl-CoA sacA CoA (R)-S-oxide hydroxyacyl-(acyl a (3R)-3-hydroxy-12- dehydratase: fabZ 1,6-kestotetraose a proteinogenic L-glutamate-5- glucopyranose α-D-glucan 2-oxoglutarate -methyl-ester L-galactopyranose carrier protein] YrrS reductase: fabG β -butenyl 4- bacilysin dehydrogenase: 3-phospho- a (6S)-5- YflA carrier protein) methyltridecanoyl-[acp] acetyltransferase: dTDP- -L-rhamnose diphosphate deoxyribose- unsaturated amino acid semialdehyde an N-terminal L- [+ 2 isozymes] putative hydroxyacyl- diphosphate D-glycerate β D-glucopyranose 6-phosphate D-glucopyranose formyltetrahydrofolate formate 1-phosphate dehydratase: gcaD biosynthesis 1-hydroxy-2- isomerase: fni fadN phosphate rhamnogalacturonyl β-D-fructofuranose -D-glucose methionyl-[protein] beta-hydroxyacyl- (acyl carrier protein) fructose-1,6- N-acetyl-α-D- reductase: (S)-3- phosphoglycerate 6-phosphate ycsD a (3R)-3-hydroxytetradecanoyl-[acp] fructose-1,6- α-D-glucopyranose methyl-2-(E) ispH pulcherrimin (2R,4S)-2-methyl-2,3,3,4- aldolase: hydrolase: yteR [acyl carrier protein] dehydratase: ycsD bisphosphate glucosamine hydroxybutanoyl- mutase: pgm fructokinase: bisphosphate 1-phosphate -butenyl 4- 3-methylthiopropanoate tetrahydroxytetrahydrofuran deoC rhamnogalacturonan β YtzI a (2E,10S)-10- dehydratase: fabZ aldolase: fbaA 1-phosphate DMAPP CoA a ring-opened 7- an [HPr]- phosphoenol (S)-3-hydroxy-(9Z) (S)-1-pyrroline- a -(1,4)- YsdA a (2E)-13-methyltetradec- aldolase: fbaA glucose-1-phosphate diphosphate biosynthesis 2-phospho- gmuE NADP + a reduced fumarate a cis,cis-delta13,25- (2E,6E)-farnesyl starch squalene methyldodec-2-enoyl-[acp] beta-hydroxyacyl- IPP hydrolase: yesR methylguanine L-histidine pyruvate a tRNA precursor asp a 3-oxoicosanoyl-[acp] 5-carboxylate D-mannan a protein putative hydroxyacyl- 2-enoyl-[acp] UDP-N- thymidylyltransferase: UDP-α-D-galactose reductase: enoyl-CoA D-glycerate D-glyceraldehyde flavodoxin 3-hydroxyC44:2-[acp] -octadecenoyl-CoA diphosphate [acyl carrier protein] 1,2-dihydroxy-5- acetaldehyde in DNA enoyl-CoA delta-1-pyrroline- exported squalene- enoyl-acyl enoyl-acyl (acyl carrier protein) acetylglucosamine spsI biosynthesis hydratase / 3- 3-phosphate 4-deoxy-L-threo-hex- acetoin degradation F6P beta-ketoacyl-acyl beta-ketoacyl- farnesyl ATP-dependent dehydratase: fabZ enoyl-acyl enoyl-acyl ispH (methylsulfanyl) hydratase / 3- 5 carboxylate mannan hopene dehydratase: ycsD pyrophosphorylase: dTDP-α-D-glucose hydroxyacyl-CoA enolase: L-rhamnopyranose carrier protein acyl carrier diphosphate Clp protease alpha- carrier protein carrier protein β isopentenyl pent-1-en-3-one 4-enopyranuronate phosphotransferase endo-1,4-beta- HtpX putative hydroxyacyl- carrier protein carrier protein -D-fructose 1,6- α acireductone eno an [acetoin + L-aspartate reductase: fabG hydroxyacyl-CoA dehydrogenase: cyclase: reductase III: fabL reductase: fabI β-D-fructose 1,6- gcaD dTDP-glucose UDP- -D-glucose dehydrogenase: L-arabinose formamidopyrimidine- system (PTS) flavodoxin--NADP ribonuclease protein phosphatase: proteolytic amylase: YhjE (acyl carrier protein) reductase III: fabL reductase: fabI bisphosphate diphosphate dioxygenase dehydrogenase oxidase: dehydrogenase: rocA mannosidase: sqhC a (2E)-12-methyltridec-2-enoyl-[acp] bisphosphate UDP-N-acetyl- 4,6-dehydratase: putative fadN phosphoenol degradation I DNA glycosidase: mutM enzyme I: ptsI reductase: yumC Z: rnz [+ 2 isozymes] reductase: fabG yisP subunit: clpP amyE isomerase: fni (Ni2+ or Fe2+- 6 nadB gmuG a (10S)-10- dehydratase: ycsD fructose 1,6- α E2 protein] N a cis,cis-delta13,25- fadN β (2E,6E)-farnesol hop-22(29)-ene fructose 1,6- -D-glucosamine spsJ UDP-glucose enoyl-CoA pyruvate glucose and glucose-1-phosphate degradation acetoin [+ 2 isozymes] 3-oxo-(9Z)- glu a -(1,4)-mannan a peptide methyldodecanoyl-[acp] enoyl-acyl enoyl-acyl a 13-methyltetradecanoyl-[acp] bisphosphatase requiring) acetyl-CoA -lipoyl-L-lysine L-arabinopyranose 3-oxo-C44:2-[acp] a (3R)-3- bisphosphatase dTDP-4-dehydro-6- epimerase: ytcB hydratase: pyruvate dehydrogenase an [HPr protein]- octadecenoyl-CoA oligosaccharide YrkJ a (2E)-tetradec-2-enoyl-[acp] carrier protein carrier protein class II: glpX : mtnD L-arabinose a [DNA]- 2,6-diamino-4- NADPH an oxidized H + hydroxyicosanoyl-[acp] glucose maltose beta-ketoacyl- α DMAPP 3-(methylsulfanyl) α-D- acetoin E1: acoA acoB a 5'-phospho- π pyruvate a single-stranded 2-iminosuccinate succinate ComQ class II: glpX deoxy- -D-glucopyranose UDP-glucose 4- fadB kinase: pyk D-glucopyranose isomerase: nucleotide- hydroxy-5-(N-methyl) 4-oxo-2-pentenal N -phospho- flavodoxin mature tRNA acyl carrier reductase III: fabL reductase: fabI fructose-1,6- propanoate glucopyranose dehydrogenase acoC acoL [DNA] oligoribonucleotide enoyl-acyl beta-ketoacyl-acyl fructose-1,6- putative dTDP-4- epimerase: galE araA 3'-phosphate formamidopyrimidine L-histidine bisphosphatase: fbp UDP-α-D-galactose crotonyl-CoA 1-phosphate glucose 1- E1: acoA acoB protein synthase carrier protein carrier protein dehydrorhamnose pyruvate L-ribulose a 12-methyltridecanoyl-[acp] bisphosphatase: fbp acoC acoL II (involved 3,5-epimerase: spsL dehydrogenase: YyaJ reductase: fabI synthase II F6P alpha- PRPP biosynthesis glycolytic gdh [+ 3 isozymes] an [acetoin 10 a (3R)-3-hydroxytetracosanoyl- a pyrimidine β-D-fructofuranose a DNA containing a protein in pimelate (involved in pimelate 13-methyltetradecanoate F6P dTDP-4-dehydro- L-ribulokinase: an L-methionyl- an N - a cis,cis-delta11,23- a long-chain (3S)- di-trans,octa-cis a [protein]- YxlG phosphoglucomutase: and pentose an [acetoin [acp domain within a penicillin nucleoside an apurinic/ an aliphatic amine synthesis): fabF β dehydrogenase araB Met formyltetrahydrofolate 1-phosphate 3-hydroxyacyl-CoA with incorrect -undecaprenol L-tyrosine an L-amino acid a myristoyl-[acp] beta-ketoacyl-acyl synthesis): fabF glucose-6- -L-rhamnose D-glucono- dehydrogenase [initiator tRNA ] 3-hydroxyC42:2-[acp] dATP glucose-6- D-ribose 5- pgcA phosphate E2 protein] N 6 -S- a fatty acid synthase]beta-hydroxyacyl- beta-ketoacyl-acyl enoyl-CoA apyrimidinic site disulfide bonds protein putative phosphate 1,5-lactone 6 acetoin L-ribulose 5- a (12S)-12-methyl-3- carrier protein phosphate phosphate putative dTDP-4- butanoyl-CoA intermediates E2 protein] N - putative thiol-disulfide undecaprenol kinase: amino acid beta-ketoacyl-acyl isomerase: pgi acetyldihydrolipoyl- [acyl carrier protein] pyrimidine- carrier protein hydratase / 3- endonuclease amine YfiG oxotetradecanoyl-[acp] synthase II phosphoribosylpyrophosphate dehydrorhamnose D-glucopyranose dihydrolipoyl-L-lysinedehydrogenase phosphate penicillin fructose-1,6- pyrophosphohydrolase: oxidoreductase: kinase: dgkA racemase: a 15-methyl-3- isomerase: pgi phosphatase: trehalose degradation L-lysine dehydratase: fabZ nucleoside hydroxyacyl-CoA V: ywqL tsaE oxidase: carrier protein 12-methyltridecanoate D-glucopyranose synthetase: prs reductase: spsK phosphate pyruvate fermentation E1: acoA acoB methionyl-tRNA amidohydrolase: bisphosphate reductase: fabG YdgH beta-ketoacyl- (involved in pimelate oxohexadecanoyl-[acp] superpathway of purine nucleotides de novo biosynthesis II Nucleoside and Nucleotide Biosynthesis 6-phosphate araL L-ribulose-5- yvdC dehydrogenase: ahpT di-trans,octa-cis [+ 2 isozymes] racX yobN synthase II D-glucopyranose UMP biosynthesis III butyryl I (low osmolarity) acoC acoL putative hydroxyacyl- yxeI phosphorylase: [+ 2 isozymes] a 2'- a protein a [protein]- synthesis): fabF phosphatidylglycerol 6-phosphate PRPP β uridine-5'-phosphate biosynthesis pyrimidine deoxyribonucleotides CMP pyrimidine to (R)-acetoin II phosphate 4- formyltransferase: fmt aldolase: fbaA [+ 2 isozymes] acyl carrier (involved in pimelate beta-ketoacyl-acyl 6-phosphate dTDP- -L-rhamnose α α pdp a cis,cis-delta11,23- fadN deoxyribonucleoside -undecaprenyl an aldehyde biosynthesis II (non-plastidic) de novo biosynthesis I pyrimidine phosphorylation ribonucleotides coenzyme A D-gluconate , -trehalose epimerase: (acyl carrier protein) a long-chain 3- with correct L-tyrosine a D-amino acid protein synthesis): fabF carrier protein D-glucopyranose 3-oxo-C42:2-[acp] dAMP 5'-monophosphate phosphate RsiO PRPP ribonucleosides salvage I interconversion transferase: pyruvate 6-phosphate araD dehydratase: ycsD disulfide bonds phosphate reductase: fabG a 14-methyl-3- gln hydrogencarbonate UDP CTP CMP TCA cycle an N-formyl- oxoacyl-CoA reductase: fabG DHAP hydrogencarbonate UMP ptb acetolactate α-D-glucose a (2E)-tetracos-2-enoyl-[acp 6-aminopenicillanate a carboxylate a pyrimidine base α-D-ribose- DHAP D-glyceraldehyde [+ 2 isozymes] a 3-oxohexadecanoyl-[acp] oxopentadecanoyl-[acp] glutamine ribonucleoside CTP cytidine cytidylate glucose D-xylulose L-methionyl- a tetrahydrofolate YdfC [+ 2 isozymes] NAD(P)H-dependent carbamoyl phosphate cytidylate synthase: ilvH ilvB 6-phosphate trehalose-6- domain within a fatty acid synthase] 1-phosphate butanoyl acetyl-CoA maltose degradation 5-phosphate met phosphoribosylpyrophosphate reductase: phosphohydrolase: kinase: cmk purine deoxyribonucleosides salvage TCA cycle I (prokaryotic) kinase: [initiator tRNA ] a (3R,12S)-3-hydroxy-12- beta-ketoacyl-acyl a (3R)-3-hydroxy-15- glycerol-3-phosphate synthetase: carA carB kinase: cmk alpha-acetolactate phosphate beta-ketoacyl-acyl amidotransferase: purF carbamoyl- nrdE nrdF rppH cytidine CDP phosphate glcK YwnF methyltetradecanoyl-[acp] carrier protein methylhexadecanoyl-[acp] dehydrogenase: gpsA carbamoyl-phosphate CDP uridylate synthase: alsS hydrolase: carrier protein β phosphate SPbeta phage deaminase: D-glucopyranose maltose reductase: fabG 5-phospho- - gly nucleoside (S)-2-acetolactate a (3R)-3-hydroxyhexacosanoyl- 527 34 (5R)-5,6-dihydro- (2Z,4Z)-2- 2069 sn-glycerol 3-phosphate synthase (glutamine- cdd kinase: pyrH acetyl-CoA β treA a sulfurated sn-glycerol a 1,2-diacyl- a cis,cis-delta15,27- a guanine a cytidine a guanine an unfolded L-alanyl-D- AlbB beta-hydroxyacyl- reductase: fabG beta-hydroxyacyl- D-ribosylamine synthase ribonucleoside- SPbeta phage CMP diphosphate 2'-deoxyguanosine 2'-deoxyadenosine -D-glucose 6-phosphate maltose dethiobiotin SAM [acp domain within nicotinate PRPP GGPP 5-(thymidin-7-yl) hydroxyhepta- cyclohex-2-enone [+ 2 isozymes] hydrolysing): UDP [sulfur carrier] 1-phosphate sn-glycerol 3-hydroxyC46:2-[acp] in 16S rRNA in tRNA in 23S rRNA protein glutamate [acyl carrier [+ 2 isozymes] [acyl carrier protein] (glutamine- diphosphate ribonucleoside- kinase: ndk deoxyadenosine/ 6-phosphate phosphorylase: 7-methylguanosine thymidine (in DNA) 2,4-dienedioate 2-cyclohexen- m(7)G2069 pyrAA pyrAB deoxyguanosine alpha-acetolactate a fatty acid synthase]beta-hydroxyacyl- beta-ketoacyl-acyl tRNA (cytidine(34) spore (4Z)-2-oxohept- L-Ala-D/ protein] a (3R)-3-hydroxy-14- dehydratase: fabZ hydrolysing): reductase: uridine nucleoside butanoate glucose mdxK YitE phosphoribosylglycinamide diphosphate CTP deoxycytidine decarboxylase: alsD oxaloacetate β-D-glucopyranose [acyl carrier protein] carrier protein methyltransferase -2'-O)- 1-one methylase chaperonin: L-Glu dehydratase: fabZ a (3R)-3-hydroxyhexadecanoyl-[acp] methylpentadecanoyl-[acp] pyrAA pyrAB diphosphate kinase: dgk kinase: melibiose degradation nicotinate photoproduct 4-enedioate putative hydroxyacyl- synthetase: purD nrdFB nrdEB reductase: uridine kinase: dck citrate synthase: mmgD biotin dehydratase: fabZ phospholipase (16S rRNA, methyltransferase: reductase: of 23S epimerase: carbamoyl phosphate kinase: ndk 1-phosphate phosphoribosyltransferase: geranylgeranylglyceryl- reductase: fabG (thymine dimer) tautomerase: groES groEL putative beta-hydroxyacyl- (acyl carrier protein) dUDP nrdFB nrdEB kinase: udk dGMP dAMP (R)-acetoin fructose D-glucopyranose glcK synthase: B: lipC nucleotide cspR yqjM rRNA: ypsC ykfB YkaC a 2-lysophosphatidate [+ 2 isozymes] D-glucopyranose beta- putative hydroxyacyl- pncB phosphate synthase: pcrB [+ 2 isozymes] a 2'-O- lyase: splB ywhB an N 7 - hydroxyacyl-(acyl beta-hydroxyacyl- [acyl carrier protein] dehydratase: ycsD 6-phosphate melibiose bioB L-alanyl-L- carbamoyl aspartate nucleoside CDP reductase: degradation a cis,cis-delta15,27- 7 G527): rsmG 34 two adjacent (4Z)-2-oxohept- cyclohexanone 2069 [acyl carrier protein] GAR asp UMP ADP phosphoglucomutase: (acyl carrier protein) an N - methylcytidine methylguanine a protein glutamate carrier protein) dehydratase: fabZ putative 1-acyl-sn- phosphate carbamoyltransferase: nrdE nrdF 3-oxo-C46:2-[acp] thymidines in DNA 4-enedioate YoyI dehydratase: fabZ a (2E)-15-methylhexadec- diphosphate β-D-fructofuranose mdxM dehydratase: ycsD methylguanine 527 in tRNA in 23S rRNA dehydratase: glycerol-3-phosphate alpha-D-galactoside putative hydroxyacyl- 2-enoyl-[acp] phosphoribosylglycinamide pyrB kinase: ndk dCDP CTP malate dehydrogenase 1-phosphate β-D-glucose biotin 5'-deoxyadenosine an unsulfurated a (2E)-hexacos-2-enoyl-[acp NaMN a fatty acid a monoglyceride in 16S rRNA ycsD putative hydroxyacyl- acyltransferase: ypkP (S)-malate citrate fructose-1- galactohydrolase: melA met GGGP Era (acyl carrier protein) formyltransferase 2: purT aspartate synthetase: pyruvate fermentation (NAD-dependent): mdh 6-phosphate [sulfur carrier] domain within a fatty acid synthase] (acyl carrier protein) enoyl-acyl enoyl-acyl dUTP nucleoside phosphate a (2E,12S)-12- dehydratase: ycsD 1-acylglycerol- carbamoyltransferase: N-carbamoyl-L-aspartate pyrG [+ 3 isozymes] dehydratase: ycsD carrier protein carrier protein dGDP dADP to (S)-lactate kinase: fruK YitZ methyltetradec-2-enoyl-[acp] phosphate (1-acyl-G3P) FGAR pyrB dUTPase: yosS diphosphate β-D-fructose 1,6- D-galactopyranose D-glucopyranose a (2E)-14-methylpentadec- reductase III: fabL reductase: fabI kinase: ndk ATP acyltransferase: plsC [+ 3 isozymes] citrate hydro-lyase: citB bisphosphate adenine 2503 (S)-3- 1498 enoyl-acyl enoyl-acyl a (2E)-hexadec-2-enoyl-[acp] 2-enoyl-[acp] dihydroorotase: pyrC pyruvate decanoate cephalosporin C bis(p-nitrophenyl) canavaninosuccinate a cis,cis-delta19,31- acetoacetyl-CoA hexanoyl-CoA acetoin a uracil D-glycerate phosphoribosylformylglycinamidine dCTP nucleoside nucleoside fumarate hydroxydodecanoyl- ile 3',5'-ADP YqgE a phosphatidate N-carbamoyl- dUMP nucleoside L-lactate in 23S rRNA phosphate 3-hydroxyC50:2-[acp] in 16S rRNA carrier protein carrier protein enoyl-acyl enoyl-acyl a 15-methylhexadecanoyl-[acp] synthetase: purQ purL purS diphosphate diphosphate hydratase: fumC CoA 3-hydroxybutyryl- acyl-CoA acetoin methylase D- reductase III: fabL reductase: fabI enoyl-acyl L-aspartate thymidylate diphosphate dehydrogenase: ldh fumarate cis-aconitate beta-ketoacyl-acyl enoyl-CoA branched-chain 3',5'- TatAY carrier protein carrier protein (S)-dihydroorotate kinase: ndk kinase: ndk D-threo-isocitrate CoA dehydrogenase: dehydrogenase of U1498 glycerate carrier protein phosphatidate FGAM kinase: ndk (S)-lactate 23S rRNA m2A2503 promiscuous acetyl xylan carrier protein hydratase / 3- amino acid bisphosphate reductase III: fabL reductase: fabI synthase A: thyA purine and pyrimidine metabolism Inorganic Nutrient Metabolism long chain acyl-CoA argininosuccinate dehydrogenase: acdA E1: acoA acoB in 16S kinase: a (12S)-12- reductase: fabI cytidylyltransferase dihydroorotase: succinate hydro-lyase: citB methyltransferase: esterase-cephalosporin phosphodiesterase: reductase: fabG hydroxyacyl-CoA dehydrogenase: nucleotidase: dihydroorotate thymidylate ADP dGTP dATP ligase (degradative): lcfA lyase: argH mmgB acoC acoL rRNA: rsmE glxK methyltetradecanoyl-[acp] (CDP-diglyceride pyrC dehydrogenase: yhfI [+ 2 isozymes] dehydrogenase: bcd [+ 2 isozymes] an N 3 - nrnA HemX phosphoribosylaminoimidazole dehydrogenase: synthase B: thyB thymine uridine rlmN [+ 4 isozymes] C deacetylase: cah (S)-3- (2E)- 3-phospho- a 14-methylpentadecanoyl-[acp] a cis,cis-delta19,31- (3S)-3-methyl-2- 1498 a palmitoyl-[acp] synthase): cdsA synthetase: purM sdhB sdhA sdhC superpathway of sulfate assimilation and cysteine biosynthesis fadN hydroxybutanoyl- acetaldehyde methyluracil AMP TatAC 15-methylhexadecanoate (S)-dihydroorotate pyrK pyrD dTMP adenosine guanosine two-component alkanesulfonate monooxygenase 3-oxo-C50:2-[acp] 3-oxododecanoyl- oxopentanoate hexenoyl-CoA D-glycerate beta-ketoacyl- CoA in 16S rRNA a CDP-diacylglycerol PRPP 2503 AIR orotate succinate D-threo-isocitrate a 2-methyladenine 4-nitrophenyl L-canavanine fumarate CoA acyl carrier dihydroorotate thymidylate isocitrate sulfate 5'-deoxyadenosine met AMP decanoyl-CoA diphosphate acetate deacetylcephalosporin C 4-nitrophenol purine nucleoside purine nucleoside in 23S rRNA phosphate protein synthase (12S)-12- CDP-diacylglycerol- kinase: tmk thymidine uracil an alkylsulfonate FMNH YvlC N5-carboxyaminoimidazole dehydrogenase: phosphorylase: phosphorylase: succinyl-CoA dehydrogenase: icd 2 II (involved orotate putative sulfate nitrate reduction BacE methyltetradecanoate 14-methylpentadecanoate glycerol-3-phosphate 3- ribonucleotide pyrK pyrD dTDP pupG pupG thymidine transcriptional synthetase: sucC sucD in pimelate palmitate phosphoribosyltransferase: adenylyltransferase: yitA V (assimilatory) phosphatidyltransferase: synthase: purK PRPP kinase: tdk attenuator and uracil a [TusE sulfur synthesis): fabF orotate pyrE nucleoside purine nucleoside purine nucleoside Signal transduction pathways sulfate 3-phospho-D-glycerate an N-acetyl-β- α-D-glucopyranose a double an organic long chain acyl- pgsA phosphoribosyltransferase a uridine 34 in tRNA linoleate a levan sucrose a cis,cis-delta9,21-3- a nucleoside decanoyl-CoA isobutanoate Ins(1,2,3,4,5,6)P a [protein]-L-serine diphosphate phosphorylase: phosphorylase: dTMP nitrate carrier protein]-S D-hexosaminide 1-phosphate leu 6 N5-CAIR succinyl-CoA 2-oxoglutarate adenylyltransferase: sat hydroxyC40:2-[acp] stranded DNA triphosphate hydroperoxide MifM CoA ligase activity: pyrR -sulfanylcysteine acyl-CoA alkyl branched- a phosphatidylglycerophosphate orotate kinase: ndk deoD deoD 3-phosphoglycerate beta-ketoacyl-acyl 5'-3' helicase nucleoside branched-chain protein YwjB a (14S)-14-methyl-3- (degradative): lcfA orotidine 5'-phosphate DesKR two-component DegSU two-component APS assimilatory dehydrogenase: chain phytase: N5-carboxyaminoimidazole phosphoribosyltransferase: thymidylate thymidylate uracil dehydrogenase: serA carrier protein associated triphosphate hydroperoxide kinase: dTTP signal transduction system signal transduction system nitrate long chain acyl-CoA N-acetylglucosaminidase: glucose-1-phosphate levansucrase: amino acid phy oxohexadecanoyl-[acp] [+ 4 isozymes] phosphatidylserine and ribonucleotide pyrE adenine guanine kinase: tmk synthase phosphoribosyltransferase: upp tRNA-specific reductase: fabG to SSB; phosphohydrolase: acdA reductase: fatty-acid tsaE phosphatidylglycerol putative adenylylsulfate reductase NAD(P)H-flavin ligase (degradative): lcfA nagZ phosphodismutase: sacB dehydrogenase: phosphatidylethanolamine mutase: purE orotidine 5'-phosphate A: thyA 3-phosphooxypyruvate 2-thiouridylase: [+ 2 isozymes] exonuclease rppH [+ 2 isozymes] ahpF ahpC kinase: buk D-myo-inositol beta-ketoacyl- palmitoyl-CoA phosphate (PGP) UMP kinase: yisZ oxidoreductase [+ 4 isozymes] mdxM bcd (2E)-dec-2- a [protein] L- YrhC biosynthesis I decarboxylase: pyrF hypoxanthine-guanine dTDP DesK DesK-P (catalytic a cis,cis-delta9,21- V: recD2 a nucleoside 4-methyl-2- an alcohol 2-methylpropanoyl (1,2,4,5,6)- acyl carrier phosphatase; orotidine 5'- thymidylate DegS DegS-P (nitroreductase) trmU serine phosphate FlhG CAIR adenine adenylylsulfate kinase: cysC phosphoserine subunit): FMNH2-dependent diphosphate oxopentanoate enoyl-CoA phosphate pentakisphosphate protein a CDP- undecaprenyl- phosphate UMP phosphoribosyltransferase: synthase uridine an N-acetyl-β- 3-oxo-C40:2-[acp] a 5'-phosphooligonucleotide phosphoribosyltransferase: apt cytidylate aminotransferase: serC nasC nasB aliphatic sulfonate : hypO an alcohol D-glucopyranose a levan reductase: fabG fatty acid biosynthesis diacylglycerol hprT B: thyB PAPS D-hexosamine α-glucose 1,6- D-glucopyranose pyrophosphate phosphoribosylaminoimidazole superpathway of kinase: udk kinase: cmk a 2-thiouridine 34 a [TusE sulfur carrier AMP linoleoyl-CoA phosphatidylserine orotidine 5'- superpathway of pyrimidine monooxygenase: NADPH-FMN diphosphate [+ 2 isozymes] initiation III phosphatase succinocarboxamide adenosine nucleotides AMP uridylate nitrite bisphosphate synthase: pssA phosphate putative phospho- ssuD oxidoreductase in tRNA protein]-L-cysteine YwdE (promiscuous synthetase: purC de novo biosynthesis I GMP dUMP uridine nucleobases salvage O-phospho-L-serine YjdJ a (3R,14S)-3-hydroxy-14- biotin-carboxyl carrier a phosphatidylserine kinase: decarboxylase: adenylylsulfate assimilatory (nitroreductase) a malonyl-[acp] activity): yodM adenylate cytidine pyrH uracil methylhexadecanoyl-[acp] protein assembly SAICAR pyrF reductase: yitB serine phosphatase: rsbX : ycnD a [protein]- all-trans- malonyl-AcpK phosphatidylserine superpathway of IMP kinase: adk nitrite α-D-glucopyranose (S)-3-hydroxy-(5Z) Fe- a (2E,4E)-2,4- [+ 2 isozymes] guanylate deaminase: transcriptional a homogalacturonan octanoate 6-kestotriose sucrose a ribonucleoside a single a cis,cis-delta5,17-3- vanillin octanoyl-CoA ω beta-hydroxyacyl- a [biotin carboxyl- asp (phospho)adenosine phosphoserine reductase CTP 1-phosphate N -phospho- heptaprenyl gly decarboxylase: decarboxylase; UMP guanosine nucleotides cdd UDP attenuator and uracil triphosphate hydroxyC36:2[acp] -tetradecenoyl-CoA coproporphyrin III dienoyl-CoA [acyl carrier carrier protein]-L-lysine adenylosuccinate kinase: gmk phosphatase: serB stranded DNA vanillin acyl-CoA L-arginine diphosphate 2,4-dienoyl- YocS pksF 32 kDa precursor a phosphatidylglycerol de novo biosynthesis I ADP phosphoribosyltransferase phosphosulfate subunit: beta-ketoacyl-acyl enoyl-CoA coproheme tetraprenyl- YjcA protein] lyase: purB cytidine reductase: cysH hydratase / 3- dehydrogenase: yfmT III oxidative dehydrogenase: protein-arginine CoA glycine biotin acetyl-CoA- an acetyl-[acp] processed into a GDP activity: pyrR DegU-P nasE nasD urea cycle pectate lyase: pel glucose-1-phosphate carrier protein β-curcumene dehydratase: fabZ adenylosuccinate DesR-P DesR DegU ser long chain acyl-CoA levansucrase: DNA acdA phosphatase: oxidase: carboxylase 29 kDa protein: psd IMP reductase: fabG hydroxyacyl-CoA putative aldehyde decarboxylase: synthase: reductase: AICAR synthetase: purA uracil sulfite ammonium secreted pectate ligase (degradative): lcfA sacB cytidylyltransferase ywlE thiO putative ligase and beta-ketoacyl- primase: dehydrogenase: dehydrogenase: aldY hemQ [+ 2 isozymes] fadH phosphoribosyltransferase: upp (polygalacturonate) (sporulation): spsN [+ 2 isozymes] a [protein]- ytpB a (3E)-3- pyrimidine deoxyribonucleotides serine O- ammonium [+ 4 isozymes] dnaG a cis,cis-delta5,17- fadN (2E)-oct-2- tetraprenyl- YvsG hydroxyacyl-(acyl biotin regulon acyl carrier a phosphatidylethanolamine fused inosine- UMP lyase: pelC vanillate protoheme glyoxylate YerB biosynthesis from CTP adenylo-succinate CMP acetyltransferase: cysE an aldehyde FMN 3-oxo-(5Z)- enoyl-CoA L-arginine β-curcumene enoyl-CoA carrier protein) repressor: birA protein synthase phosphoribosylaminoimidazole monophosphate sulfite reductase: cysI cysJ glutamine glutamate 3-oxo-C36:2-[acp] arg carbamoyl 6,6-kestotetraose D-glucopyranose CDP-α-D-glucose tetradecenoyl-CoA dehydratase: II (involved carboxy formyl formyltransferase; CTP superpathway of pyrimidine deoxyribonucleoside salvage cytidylate cytidylate kinase: cmk synthetase: synthase: a [biotin carboxyl-carrier dehydrogenase: guaB adenylosuccinate LytST two-component phosphate an unsaturated pectate AMP octanoyl-CoA diphosphate ssDNA/pppN(pN) 6 uridylate kinase: pyrH NatKR two-component O-acetyl-L-serine ycsD protein]-N -biotinyl-L-lysine in pimelate inosine-monophosphate kinase: cmk hydrogen sulfide glnA gltB gltA a homogalacturonan hybrid CTP lyase: purB signal transduction system signal transduction system synthetase: oligosaccharide n -1 synthesis): fabF cyclohydrolase: purH XMP 2'-deoxycytidine CDP UDP YbdG YhaJ a (2E,14S)-14- phosphohydrolase: argininosuccinate carA carB arginase: methylhexadec-2-enoyl-[acp] rppH AMP nucleoside cysteine synthase: cysK nitrate lyase: argH an acetoacetyl-[acp] FAICAR deoxycytidine deoxyadenosine/ NatK NatK-P LytS LytS-P gln glu carbamoyl- 3-oxo-(9Z)- a non-methylated (7Z)- a (2E,4Z)-2,4- cellulose a [biotin carboxyl- diphosphate kinase: ndk reduction III argI pentadecanoate stearate (2E)-dodec-2-enoyl-CoA an mRNA a cis,cis-delta9,27-3- Ins(1)P butanoyl-CoA enoyl-acyl enoyl-acyl CDP GMP deaminase: cdd deoxycytidine O-acetylserine phosphate octadecenoyl-CoA ribosomal hexadecenoyl-CoA L-homocysteine GTP dienoyl-CoA carrier-protein dimer]- fused adenylate (dissimilatory) enoyl-CoA hydratase ribosome- hydroxyC46:2-[acp] acyl-CoA endo- carrier protein carrier protein synthetase: guaA kinase: dck UTP thiol-lyase: mccA synthase beta-ketoacyl-acyl protein L11ribosomal acyl-CoA 2,4-dienoyl- YknV 6 kinase: adk inositol YnzE N -biotinyl-L-lysine phosphoribosylaminoimidazole SPbeta phage L-arginino- (glutamine- / 3-hydroxyacyl-CoA dependent mRNA dehydrogenase: dehydrogenase: homocysteine CoA 1,4-beta- reductase III: fabL reductase: fabI 2'-deoxyuridine adenine salvage putative cysteine nitrate L-ornithine acetyl-CoA C- carrier protein protein L11 monophosphatase: diguanylate acetyl-CoA carboxy formyl formyltransferase; ribonucleoside- CTP synthetase: pyrG succinate long chain acyl-CoA long chain acyl-CoA dehydrogenase: fadN endonuclease: raeA acdA acdA gamma- reductase: glucanase: ADP dCMP synthase-like enzyme: ytkP nitrate hydrolysing): reductase: fabG methyltransferase: cyclase: dgcP a (14S)-14- inosine-monophosphate diphosphate GMP ligase (degradative): lcfA ligase (degradative): lcfA acyltransferase: suhB lyase: mccB eglS acetyl-CoA carboxylase thymidine reductase: pyrAA pyrAB enoyl-CoA endoribonuclease: [+ 2 isozymes] prmA [+ 2 isozymes] [+ 2 isozymes] [+ 2 isozymes] fadH methylhexadecanoyl-[acp] reductase: cytidylate CTP [+ 4 isozymes] [+ 4 isozymes] fadA a methylated (2E,7Z)- a (3E)-3- carboxylase: subunit (biotin cyclohydrolase: purH kinase: tdk narI narH hydratase: fadB ndoA a cis,cis-delta9,27- myo-inositol crotonyl-CoA 2-oxobutanoate a cellodextrin YdgF carbamoyl ribosomal hexadecenoyl-CoA c-di-GMP enoyl-CoA YqfU accA accD carboxylase nrdFB nrdEB kinase: cmk adenine cys narG 3-oxo-C46:2-[acp] guanylate thymidine phosphate (S)-3-hydroxydodecanoyl-CoA an mRNA fragment protein L11 subunit): accC CDP dUMP dCDP nitrite ornithine (7Z)- IMP kinase: gmk argininosuccinate AMP pentadecanoyl-CoA AMP acetyl-CoA a [carboxyl-carrier reductase: carbamoyltransferase: diphosphate diphosphate stearoyl-CoA hexadecenoyl-CoA nucleoside NatR-P NatR LytT-P LytT synthase: argG (14S)-14- protein dimer]-N 6 - nrdE nrdF GDP dADP thymidylate thymidine putative adenine argF diphosphate L-citrulline GanP methylhexadecanoate carboxybiotinyl-L-lysine synthase A: thyA adenine phosphoribosyltransferase: apt YonS dCDP kinase: tdk kinase: ndk nucleoside thymidylate deaminase 3-oxo-(7Z)- 1516 RNase II inosine- nucleoside an oxidized c- a proteinogenic glutathione isomaltose (2E)-hexenoyl-CoA a cis,cis-delta13,31-3- a cis,cis-delta7,19-3- a guanine oleoyl-CoA acetaldehyde a fatty acid fructosevaline catechol diphosphate synthase B: thyB dCTP YerA: yerA degradation cys monophosphate nucleoside diphosphate AMP amino acid hexadecenoyl-CoA hydroxy C50:2-[acp] hydroxyC38:2-[acp] in 16S rRNA kinase: ndk type cytochrome enoyl-CoA hydratase putative 16S acyl-CoA fatty acid beta- substrate mRNA dehydrogenase: diphosphate kinase: ndk adenine beta-ketoacyl-acyl beta-ketoacyl-acyl putative aldehyde catechol-2,3- YkoX YufLM two-component signal BceSR two-component Carboxylate Degradation / 3-hydroxyacyl-CoA rRNA m(2)G1516 dehydrogenase: fructosevaline cysteine BofB deaminase: putative oligo-1,6- carrier protein carrier protein dehydrogenase: hydroxylating ribonuclease dioxygenase: guaB kinase: ndk dCMP transduction system, malate-dependent signal transduction system dehydrogenase: fadN acetyl-CoA C- acdA kinase: frlD desulfhydrase: dGDP dATP adeC reductase: fabG reductase: fabG methyltransferase: aldY cytochrome R: rnr catD catE asp salvage pathways of pyrimidine membrane bound gamma- glucosidase: yugT acyltransferase: mccB YufL two-component superpathway of hexuronide enoyl-CoA 2 ypiP [+ 2 isozymes] P450: cypC dCTP dCMP dTMP isomaltose α- fadA [+ 2 isozymes] [+ 2 isozymes] an N - fructosevaline- GTP superpathway of 5-aminoimidazole deoxyribonucleotides 2-methylcitrate cycle I pyruvate decarboxylation to acetyl CoA I glutamyltranspeptidase: ggt (2E,9Z)- acetate a 3- or 2- a nucleoside 5'- HMS deaminase: nucleoside YufL sensory histidine BceS BceS-P and hexuronate degradation 2-oxobutanoate hydratase: fadB a cis,cis-delta13,31- a cis,cis-delta7,19- 1516 pyruvate YbeF thymidylate glucosidase: mdxL methylguanine octadecenoyl-CoA hydroxy fatty acid 6-phosphate adenylosuccinate diphosphate ribonucleotide biosynthesis 2'-deoxycytidine kinase, modified degradation I 3-oxo-C50:2-[acp] 3-oxo-C38:2-[acp] monophosphate XMP comEB kinase: tmk hypoxanthine a [pyruvate dehydrogenase (S)-3-hydroxyhexanoyl-CoA in 16S rRNA SpoVB synthetase: purA kinase: ndk a β-D-glucuronoside propanoate (5Z)- deoxycytidine 6 an α-(γ-L-glutamyl) acetyl-CoA dUMP dTDP PRPP E2 protein] N -lipoyl-L-lysine L-cysteinylglycine long chain acyl- 2-oxobutanoate Alcohol Degradation -L-amino acid α-D-glucopyranose D-glucopyranose tetradecenoyl-CoA GMP glutamine hypoxanthine-guanine deaminase: cdd branched-chain adenylo-succinate guanine and thymidylate dGTP nucleoside CoA ligase branched-chain SkfF synthetase: phosphoribosylpyrophosphate phosphoribosyltransferase: alpha-keto acid guanosine salvage I synthase diphosphate 2'-deoxyuridine (degradative) alpha-keto acid guaA hprT dehydrogenase glycerol and glycerophosphodiester degradation SpoIIM adenylosuccinate amidotransferase: purF 1402 38- A: thyA kinase: ndk 5-phospho-β- D-glucopyranuronate : lcfA dehydrogenase a pyrimidine base a β-D-fructofuranoside a cis,cis-delta5,23-3- a cytidine a uridine pyrimidine- E3 subunit pyruvate sucrose (2E)-dec-2-enoyl-CoA a cis,cis-delta15,33-3- spermidine benzaldehyde amicoumacin A histidinol dodecyl sulfate lyase: purB thymidylate D-ribosylamine thymidine [+ 4 isozymes] E2 subunit (R,R)-butanediol lesion in DNA in 16S rRNA 40 in tRNA lys GMP guanosine dTTP IMP (dihydrolipoamide dehydrogenase: glycerol hydroxy C52:2-[acp] hydroxyC42:2-[acp] synthase kinase: tdk nucleoside salvage pathways of pyrimidine ribonucleotides YufM two-component propanoyl-CoA (lipoamide degradation enoyl-CoA hydratase beta-ketoacyl-acyl beta-ketoacyl-acyl 16S rRNA 2'-O- spermine/ putative aldehyde tRNA histidinol SDS YqeW AMP purine nucleoside phosphoribosylglycinamide phosphorylase: dehydrogenase) pdhA pdhB / 3-hydroxyacyl-CoA ribose C1402 spermidine pseudouridine amicoumacin lysine 2,3- B: thyB response regulator, MalR BceR-P BceR acyltransferase) sucrose-6-phosphate sucrose-6- carrier protein carrier protein dehydrogenase: dehydrogenase: oxidation: phosphorylase: pupG xanthine and xanthosine salvage synthetase: purD dUMP 2-methylcitrate : lpdV a glycerophosphodiester (R,R)-2,3- A kinase: yerI aminomutase: YdeR guanylate pdp cytidine phosphorylated : bkdB endonuclease dehydrogenase: fadN phosphate reductase: fabG reductase: fabG methyltransferase: acetyltransferase: aldY (38-40) hisD yetO dTMP aldehydo-D- synthase: butanediol hydrolase: sacA kamA adenylate purine nucleoside [+ 2 isozymes]a [pyruvate dehydrogenase a [pyruvate dehydrogenase propanoyl-CoA acetoin reductase/ III: nth enoyl-CoA yabC bltD synthase: truA kinase: gmk GAR aldehydo-D-glucuronate sucrose α- hydrolase: sacA [+ 2 isozymes] [+ 2 isozymes] a 2'-O- 1 38- amicoumacin kinase: adk phosphorylase: deoD 2-deoxy-α- cytidine galacturonate mmgD E2 protein] N 6 - E2 protein] N 6 -S- N - benzoate a pseudouridine β oxidized SDS thymidylate secreted glycerol 2,3-butanediol hydratase: fadB a cis,cis-delta15,33- a cis,cis-delta5,23- 1402 his L- -lysine PucJ adenine and adenosine salvage I cytosine glucosidase: mdxL methylcytidine 40 in tRNA A 2-phosphate GDP guanine kinase: tmk xanthosine D-ribose 1- deaminase: galacturonate galacturonate (2S,3S)-2- dihydrolipoyl-L-lysine acetyldihydrolipoyl-L-lysine putative dehydrogenase: 3-oxo-C52:2-[acp] 3-oxo-C42:2-[acp] acetylspermidine ADP phosphoribosylglycinamide phosphoribosylglycinamide phosphodiesterase a [DNA]-3'-α,β- (S)-3-hydroxydecanoyl-CoA in 16S rRNA phosphate cdd isomerase: uxaC isomerase: uxaC methylcitrate acyl-CoA bdhA a 5'-phospho- a modified β-D-fructofuranose a glycoside YbfM dTDP purine nucleoside formyltransferase 2: purT formyltransferase: purN CMP YxdKJ two-component (endo-hydrolysis at unsaturated hypoxanthine-guanine CitST two-component carboxylase: glycerol (R)-acetoin [DNA] nucleobase phosphorylase: deoD signal transduction system 2-methylcitrate non-specific sites aldehyde β-D-fructofuranose D-glucopyranose nucleoside phosphoribosyltransferase: adenosine cytidylate D-tagaturonate D-fructuronate yqjD kinase (sn- nucleoside FGAR uridine signal transduction system dehydratase: throughout the cell TuaF diphosphate hprT purine nucleoside purine nucleoside kinase: cmk glycerol-3- diphosphate phosphorylase: pupG thymidine tagaturonate fructuronate prpD (S)-methylmalonyl- wall teichoic acid kinase: ndk xanthine phosphorylase: pupG CDP YxdK YxdK-P pyruvate phosphate kinase: ndk phosphoribosylformylglycinamidine reductase reductase: cis-2- CoA polymer): phoD a generic a ribonucleoside adenine 37 a uridine 55 a β-D-glucan with FliY purine nucleoside thymidine CitS CitS-P generating) oleate uroporphyrinogen-III a cis,cis-delta7,25-3- maltose formaldehyde amicoumacin B ferroheme o GMP dehydrogenase L-homocysteine 2',3'-cyclic val ser dGDP dADP dTTP synthetase: purQ purL purS nucleoside (altronate uxuB methylaconitate putative polynucleotide substrate in tRNA in tRNA a C3-substituted phosphorylase: deoD kinase: tdk acetyl-CoA [+ 3 isozymes] : glpK hydroxyC44:2-[acp] 1 xanthine uracil (dihydrolipoamide D-glucarate uroporphyrinogen homocysteine S- phosphate beta-ketoacyl-acyl tRNA1(Val) maltose O- tRNA glucose YlaF adenine diphosphate oxidoreductase) cis-2- methylmalonyl- putative aldehyde amicoumacin endo-beta- L-serine heme a GTP phosphoribosyltransferase: xpt FGAM uridine D-mannonate acetyltransferase degradation II III and precorrin-1 C- 2',3'-cyclic-nucleotide (adenine(37)-N6)- acetyltransferase: pseudouridine ATP dTMP kinase: ndk transcriptional : uxaB methylaconitate CoA methyltransferase: yitJ carrier protein dehydrogenase: 1,3-1,4 synthase: E2 subunit): pdhC sn-glycerol endonuclease: long chain acyl-CoA methyltransferase: sumT 2'-phosphodiesterase: methyltransferase: 55 synthase: B kinase: yerI dehydratase: nucleoside nucleoside attenuator and uracil kinase: udk hydratase: citB epimerase: yqjC homocysteine methylase reductase: fabG maa aldY glucanase: ctaA YqeZ phosphoribosylaminoimidazole CTP D-glucarate 3-phosphate ligase (degradative): lcfA yfkN 6-O-acetyl-α-D- sdaAB sdaAA adenine phosphoribosyltransferase D-altronate yhcR uroporphyrin-III C- 6 yabB truB diphosphate diphosphate XMP D-mannonate branched-chain (R)-methylmalonyl- using (R,S)AdoMet: ybgG [+ 2 isozymes] an N - 55 amicoumacin bglS synthetase: purM (2R,3S)-2- glucarate [+ 4 isozymes] a ribonucleoside glucopyranosyl- formate a pseudouridine ferroheme a kinase: ndk kinase: ndk phosphoribosyltransferase: apt activity: pyrR dehydratase: alpha-keto acid methyltransferase: nasF a cis,cis-delta7,25- methyladenine 37 B 2-phosphate β pyruvate YheC methylisocitrate CoA dehydratase: met 3'-phosphate (1->4)-D-glucose in tRNA a -D glucan uracil altronate uxuA dehydrogenase precorrin-2 3-oxo-C44:2-[acp] in tRNA val AIR gudD a 3' phosphooligonucleotide 1 AMP 2-methylisocitrate 5-dehydro-4- a nucleoside 3'- phosphoribosyltransferase: upp dehydratase: E2 subunit AMP oleoyl-CoA YutH CitT-P CitT YxdJ-P YxdJ lyase: mmgF RNA monophosphate diphosphate dGTP dATP UMP uxaA (lipoamide deoxy-D-glucarate DHAP D-galactarate acyltransferase) 5-dehydro-4- YdgD succinate succinyl-CoA degradation II : bkdB deoxyglucarate 2-dehydro-3- 1915 748 1402 a (1->4)-β- dehydratase: ycbC a single a pseudouridine a guanine a cytidine an L-glutamyl- a nucleoside lichenan KapB DMAPP 37 (2E)-oct-2-enoyl-CoA chorismate an aldehyde thr D-galactan (S)-malate deoxy-D-gluconate galactarate stranded DNA an adenosine in tRNA in 23S rRNA in 23S rRNA in 16S rRNA Gln 2,5- enoyl-CoA hydratase [tRNA ] arabinogalactan diphosphate endo-beta- WalKR two-component CssSR two-component 2-keto-3- D-galactarate 23S rRNA 16S rRNA m4C1402 4-amino-4- putative aldehyde malolactic AraE superpathway of L- Amino Acid Biosynthesis dioxopentanoate glutamyl-tRNA(Gln) threonine 3- β nucleoside superpathway of L- L-histidine biosynthesis L-serine biosynthesis I L-lysine biosynthesis II superpathway of L-methionine superpathway of L-serine signal transduction system signal transduction system dehydratase: / 3-hydroxyacyl-CoA (pseudouridine1915- 23S rRNA m(1)G748 deoxychorismate endo-1,4- - 1,3-1,4 isoleucine biosynthesis I superpathway of L-tryptophan biosynthesis superpathway of L- superpathway of L-methionine L-methionine salvage cycle I (bacteria and plants) deoxygluconate pyruvate fermentation to acetate IV methyltransferase: dehydrogenase: diphosphate enzyme: biosynthesis (by sulfhydrylation) and glycine biosynthesis I glycolate and garD 2,5-dioxovalerate exodeoxyribonuclease tRNA dehydrogenase: fadN N3)-methyltransferase: methyltransferase: tlrB amidotransferase: synthase: dehydrogenase: galactosidase: glucanase: phenylalanine biosynthesis tyrosine biosynthesis biosynthesis (transsulfuration) kinase: kdgK 5-dehydro-4- rsmH aldY kinase: ndk ytsJ dehydrogenase 1 4 gatC gatA gatB tdh ganB bglS YndG D-erythrose superpathway of aromatic amino acid biosynthesis glyoxylate VII: xseB xseA isopentenylpyrophosphate enoyl-CoA 3 yydA an N - an N - pabB pabA oxaloacetate phosphoenol D-erythrose phosphoenol PRPP superpathway of L- 3-phospho-D-glycerate WalK WalK-P deoxy-D-glucarate an N - a (1->4)-β- D-erythrose phosphoenol asp oxaloacetate 3-phospho-D-glycerate CssS CssS-P pyruvate (alpha-ketoglutaric transferase: miaA 748 1402 an L-glutaminyl- 4-amino-4- a carboxylate a nucleoside (S)-lactate 4-phosphate pyruvate oxaloacetate homoserine and L- met KDGP degradation II hydratase: fadB 1915 methylguanine methylcytidine aminoacetone a short glucan putative aspartate 4-phosphate pyruvate 3-phosphoglycerate 2-oxo-4-methylthiobutanoate- methylpseudouridine Gln D-galactan YdbO D-erythrose 4-phosphate pyruvate aspartate 2-oxoglutaramate 5-dehydro-4- semialdehyde in 23S rRNA in 16S rRNA [tRNA ] deoxychorismate triphosphate aminotransferase: ATP methionine biosynthesis glutamine 3-phosphoglycerate glycolate (S)-3-hydroxyoctanoyl-CoA in 23S rRNA 4-phosphate putative aspartate dehydrogenase: serA kinase III: thrD putative aspartate deoxyglucarate dehydrogenase) a ribonucleoside a single-stranded aspB 3-deoxy- phosphoribosyltransferase: aminotransferase: mtnE dehydrogenase: serA glycolate N 6 -(3-methylbut-2-en-1- 3-deoxy- 3-deoxy- aminotransferase: asp 3-phosphooxypyruvate aspartate aminotransferase: 2-oxoglutaramate S-adenosylmethionine 2-keto-3- dehydratase: ycbC : ycbD 5'-monophosphate oligodeoxyribonucleotide D-arabino- 3-deoxy- hisG 3-phosphooxypyruvate oxidase: 37 YwdK asp D-arabino- aspB amidase: mtnU synthetase: metK yl)-adenosine in tRNA D-arabino- D-arabino- aspB kinase I: dapG deoxygluconate- 2,5- YqeF heptulosonate heptulosonate 1-(5-phospho- phosphoserine glcF glcD 2-oxoglutarate heptulosonate heptulosonate aspartate aspartate phosphoserine 6-phosphate dioxopentanoate acetyl-CoA formate aspartate 7-phosphate 7-phosphate β-D-ribosyl)-ATP aminotransferase: asp 2-oxoglutarate glyoxylate 7-phosphate asp kinase kinase II: lysC aldolase: kdgA a dimer of non-adjacent a peptidoglycan dimer (meso 1518 2251 22 synthase: aroA 7-phosphate serC 4-(methylsulfanyl)-2-oxobutanoate SAM aminotransferase: serC 2,5-dioxovalerate adenine / guanosine an adenine a ribonucleoside a monocarboxylic (2R,3S)-3- (2E,4Z)-deca- kinase synthase: aroA synthase: aroA III: thrD hν an L-arabinan wound RNA ferulate citrate starch synthase: aroA phosphoribosyl-ATP L-aspartyl-4-phosphate dehydrogenase 2'-deoxycytidine and -diaminopimelate containing) adenine 1519 in 16S rRNA in 23S rRNA in tRNA acid amide isopropylmalate 2,4-dienoyl-CoA BrnQ III: thrD aspartate aspartate phosphotransacetylase: pta arabinan-endo 1,5- 5'-monophosphate pyrophosphohydrolase: hisI sulfate CssR-P CssR D-glyceraldehyde thymidine in DNA 22 1 2,4-dienoyl- alpha- 3-deoxy- 3-deoxy-D-arabino- aspartate O-phospho-L-serine O-phospho-L-serine WalR-P WalR pyruvate (alpha-ketoglutaric dimethyladenosine 23S rRNA (Gm2251) tRNA (adenine -N ) 5' nucleotidase, putative amidase ATP-dependent isopropylmalate ferulate aconitate YxaH aspartate 3-deoxy- 3-deoxy- kinase kinase 3-phosphate oxalate α-L-arabinase: abnA CoA D-arabino- heptulosonate 1-(5-phospho-β- kinase aspartate- S-adenosylmethionine semialdehyde superpathway of acetate DD- 16S ribosomal RNA -methyltransferase: -methyltransferase: promiscuous: yutF (isochorismatase helicase: mrfA dehydratase: decarboxylase: hydratase: amylase: kinase D-arabino- D-arabino- III: thrD III: thrD putative sulfate acireductone degradation V excinuclease arabinan endo-1,5-alpha- reductase: heptulosonate 7-phosphate D-ribosyl)-AMP I: dapG serine semialdehyde decarboxylase: speD serine phosphatase: rsbX (S)-malate dehydrogenase) acetyl phosphate utilization and formation transpeptidase: transferase: ksgA rlmB trmK 5' nucleotidase: family): yaaI [+ 2 isozymes] leuD leuC padC citB amyE heptulosonate adenylyltransferase: dioxygenase (Ni2+ or ABC (subunit 6 1518 1 I: dapG heptulosonate aspartate aspartate phosphoserine : ycbD L-arabinosidase ([Ca(2+) N -dimethyladenine 2-O- N - fadH a large- 7-phosphate 3-dehydroquinate 7-phosphate phosphoribosyl- aspartate phosphatase: rsbX dehydrogenase: yitA spoVD yfkN (2S)-2- YobJ aspartate 7-phosphate kinase kinase 1,2-dihydroxy-5-Fe2+-requiring): mtnD oxalate C): uvrC -dependent]: abnB /N 6 -dimethyladenine 1519 methylguanosine 2251 methyladenine 22 a monocarboxylate an unwound RNA 4-vinylguaiacol (2E)-dec-2- D-threo-isocitrate branched glucan 3-dehydroquinate synthase: aroB AMP kinase phosphoserine asd dAdoMet phosphatase: serB acetate acetate a ribonucleoside isopropylmalate YeeG 3-dehydroquinate I: dapG sulfate (methylsulfanyl)pent-1-en-3-one oxalate 2-oxoglutarate acetyl-CoA enoyl-CoA kinase 3-dehydroquinate I: dapG II: lysC ResED two-component L-malate kinase: ackA an α(1,5)-L-arabinan in 16S rRNA in 23S rRNA in tRNA synthase: aroB cyclohydrolase: phosphatase: serB L-aspartate 4- LiaSR two-component decarboxylase: synthetase: a peptidoglycan with II: lysC synthase: aroB synthase: aroB aspartate aspartate adenylyltransferase: sat 2-hydroxy-3-keto-5- ser signal transduction system degradation II acetate a 2'-deoxycytidine 3-dehydroquinate hisI semialdehyde putrescine signal transduction system D-gluconate oxdC acsA a thymidine in DNA D,D cross-links (meso- D-ala 3-dehydroquinate β kinase L-aspartyl- ser kinase methylthiopentenyl- spermidine synthase; spermidine acetate kinase: in DNA L-aspartyl- 3-dehydroquinate 1-(5-phospho- -D-ribosyl)- APS degradation diaminopimelate containing) PtsA 3-dehydroquinate 3-dehydroquinate II: lysC 4-phosphate 4-hydroxy- II: lysC 1- phosphate polyamine metabolism: speE serine (S)-malate oxalate ackA YuzI 4-phosphate 5-[(5-phosphoribosylamino) ResE ResE-P 3-dehydroquinate dehydratase: aroC tetrahydrodipicolinate putative phosphatase: mtnX hydroxymethyltransferase: glyA LiaS LiaS-P NAD-dependent decarboxylase: 3-dehydroquinate 3-dehydroquinate methylideneamino]imidazole- L-aspartyl- aspartate- L-aspartyl- D-gluconate acetyl phosphate acetyl-CoA aspartate- dehydratase: aroC 3-dehydroquinate synthase: dapA adenylylsulfate 2-hydroxy-5-(methylsulfanyl)- malic enzyme oxdD N-acetyl-β-D-glucosamine- a guanine 1835 a guanine 46 a guanine 966 a (1->4)- dehydratase: aroC dehydratase: aroC 4-carboxamide 4-phosphate semialdehyde (2S,4S)-4- 4-phosphate S-methyl-5'-thioadenosine D-gluconate formate methylmalonate semialdehyde a levan a uridine in tRNA a fatty aldehyde D-glycerate L-β-lysine propan-1-ol pyruvate semialdehyde 3-dehydroquinate dehydratase, kinase: yisZ 3-oxopent-1-enyl 1-phosphate (conversion 1,6-anhydro-N- in 23S rRNA in tRNA in 16S rRNA thr α-D-glucan 3-dehydroquinate 3-dehydroquinate phosphoribosylformimino- dehydrogenase: hydroxy-2,3,4,5- methylthioadenosine gly kinase: gntK levanase: sacC dehydrogenase: dehydratase, type II: yqhS aspartate- of malate into D-gluconate acetyl-β-D-muramate tRNA-dihydrouridine 23S rRNA m2G1835 tRNA (guanine-N(7)- 16S rRNA m2G966 putative aldehyde beta-hydroxyacid β-lysine N 6 - alcohol pyruvate alpha- KimA MdxJ dehydratase, dehydratase, 5-aminoimidazole aspartate- asd adenylylsulfate 2,3-diketo-5- nucleosidase: mtnN endolevanase, selectively threonine type II: yqhS tetrahydrodipicolinate pyruvate): maeA 6-phosphate phosphotransacetylase: pta synthase B: dusB methyltransferase: )-methyltransferase: methyltransferase: dehydrogenase: dehydrogenase: acetyltransferase: dehydrogenase: carboxylase: amylase: asd type II: yqhS carboxamide ribotide semialdehyde semialdehyde kinase: cysC methylthiopentyl-1- methylmalonate- 3-dehydroshikimate type II: yqhS L-aspartate 4- dihydrodipicolinate cleaves the (beta-2,6) tRNA-dihydrouridine dehydratase: amyE L-aspartate 4- isomerase: hisA dehydrogenase: dehydrogenase: [+ 2 isozymes] semialdehyde ybxB trmB ylbH aldY ohaC yodP adhB pycA phosphate enolase: mtnW N-acetylglucosaminidase: fructosyl bonds: levB 2 7 2 ilvA 3-dehydroshikimate 3-dehydroshikimate semialdehyde superpathway of branched chain amino acid biosynthesis reductase: dapB asd PAPS synthase 2: dusC an N - an N - an N - a (1->4)- semialdehyde shikimate 5- 3-dehydroshikimate asd pyruvate dehydrogenase: mmsA nagZ tartronate N6-acetyl- phosphoribulosylformimino- methylguanine 1835 methylguanine 46 methylguanine 966 a fatty acid 1-propanal oxaloacetate α-D-glucan homoserine (S)-2,3,4,5- a fructooligosaccharide a 5,6-dihydrouridine in tRNA semialdehyde L-β-lysine 2-oxobutanoate YfkQ YraO shikimate 5- dehydrogenase: AICAR-phosphate L-aspartate 4- L-aspartate 4- putative phospho- 5-(methylsulfanyl)-2,3-dioxopentyl 1-phosphate MTR ResD-P ResD homoserine shikimate 5- shikimate 5- methylthioribose LiaR-P LiaR in 23S rRNA in tRNA in 16S rRNA dehydrogenase: dehydrogenase: pyruvate tetrahydrodipicolinate semialdehyde adenylylsulfate dehydrogenase: aroD dehydrogenase: dehydrogenase: semialdehyde thr aroD hom kinase (methionine hydrogencarbonate NADH propanoyl-CoA H + 1,6-anhydro-N- hom aroD tetrahydrodipicolinate N- reductase: yitB methylthioribulose- GlcNAc shikimate aroD imidazole homoserine acetolactate homoserine salvage pathway, β threonine acetyltransferase: dapH 1-phosphate acetyl- -muramate shikimate glycerol synthase: dehydrogenase: (phospho) promiscuous): mtnK L-homoserine shikimate dehydrogenase: L-homoserine dehydratase: dehydratase: mtnB YqfX YkrP shikimate shikimate phosphate ilvH ilvB hom adenosine L-arginine biosynthesis II (acetyl cycle) Amine and Polyamine Degradation Fatty Acid and Lipid Degradation hom ilvA L-2-acetamido-6- shikimate kinase: aroK synthase: phosphosulfate YdfHI two-component a 5,10- a 5' diphospho- a guanine 37 shikimate shikimate alpha- oxoheptanedioate a uracil 54 in tRNA acetoacetate spermine 4-nitrobenzaldehyde a sugar phosphate (2E,6E)-farnesal D-glycerate meso-tartrate nicotinamide (S)-NADHX homoserine kinase: L-homoserine (2Z)-2-aminobut- L-homoserine reductase: cysH S-methyl-5-thio-D-ribulose 1-phosphate 5-MTR-1-P methylenetetrahydrofolate DMAPP kinase: hisH hisF acetolactate N-acetylglutamyl- signal transduction system N-acetylglucosamine fatty acid β-oxidation I (generic) [mRNA] in tRNA kinase: thrB aroK kinase: 2-enoate 4-aminobutanoate superpathway of 4- urea spermine 4-nitrobenzaldehyde glycolytic and shikimate 3-phosphate aroK synthase: alsS phosphate degradation I allantoin degradation tRNA(m1G37) putative aldehyde beta-hydroxyacid putative tartrate prenyl NAD(P)HX YkjA aroK putative sulfite degradation III aminobutanoate degradation degradation II RNA acetyltransferase: paiA reductase: yvgN pentose phosphate nicotinamidase: YizD D-erythro-1- O-succinyl-L- to ureidoglycolate II 5 methyltransferase: dehydrogenase: dehydrogenase: dehydrogenase: dehydratase: O-phospho- shikimate 3- cys YdfH YdfH-P N-acetyl-D- tRNA:m U-54 pyrophosphohydrolase: yvcI pncA diphosphatase: 3-phosphoshikimate 1- shikimate 3- shikimate 3- AICAR (imidazol-4- (S)-2-acetolactate homoserine O- (ammonia producing) a (3Z)-alk-3-enoyl-CoA acetoacetyl-CoA spermine/spermidine 4-nitrobenzaldehyde intermediates phosphate homoserine N-acetyl-L,L-2,6- sulfite N-acetylglutamate 5- N-acetylglutamate methyltransferase: trmD aldY ohaC ycsA nudF yxkO L-homoserine phosphate methylthioribose-1- glucosamine 4-aminobutanoate urea synthetase: yngI an N 1 - carboxyvinyltransferase phosphate yl)-glycerol acetyltransferase: gamma- 4-aminobutanoate a 5'-phospho- acetyltransferase: bltD reductase: ytbE phosphatase: araL (2E,6E)- tartronate 2-hydroxy-3- 3-phosphoshikimate 1- diaminopimelate reductase: phosphotransferase (S)-(+)-allantoin trmFO 37 acetohydroxy-acid phosphate isomerase 6-phosphateN-acetylglucosamine- 4-aminobutyrate 4-aminobutyrate urease: 1 4-nitrobenzyl methylguanine nicotinate prenol NADH threonine (5-enolpyruvoylshikimate- 3-phosphoshikimate 1- 3-phosphoshikimate 1- 3-phosphate O-succinyl-L- 2-iminobutanoate metA ornithine semialdehyde [mRNA] N -acetylspermine a sugar farnesoate semialdehyde oxosuccinate carboxyvinyltransferase cys cystathionine isomeroreductase N-acetyl- cysI cysJ (acetylglutamate (methionine salvage allantoinase: alcohol YdzK synthase: 3-phosphate carboxyvinyltransferase imidazoleglycerol- homoserine acetyltransferase; 6-phosphate aminotransferase: aminotransferase: ureC in tRNA YqzF carboxyvinyltransferase gamma- O-acetyl-L- kinase): argB dehydrogenase: thrC (5-enolpyruvoylshikimate- (NADP- diaminopimelate pathway): mtnA deacetylase: nagA pucH gabT gabT ureB ureA a 5-methyluracil 54 synthase): aroE (5-enolpyruvoylshikimate- (5-enolpyruvoylshikimate- phosphate homoserine hydrogen sulfide amino-acid argC D-glucosamine succinate succinate a tetrahydrofolate acetoacetyl-CoA AMP diphosphate 3-phosphate synthase: metI dependent): ilvC deacetylase: dapI allantoate ammonium a (2E)-2-enoyl-CoA enoyl-CoA in tRNA 3-phosphate 3-phosphate dehydratase [Mn(II) acetyltransferase: 6-phosphate semialdehyde semialdehyde thr synthase): aroE 5-enolpyruvoyl- cystathionine (2R)-2,3- N-acetyl-L- hydratase: fadB synthase): aroE synthase): aroE -dependent]: hisB gamma- argJ N-acetyl-L- 5-enolpyruvoyl- shikimate 3-phosphate 3-(imidazol-4- dihydroxy-3- L,L-diaminopimelate O-acetylhomoserine glu gln glutamate 5- allantoate succinate- succinate- succinate- enoyl-CoA YoeA 5-enolpyruvoyl- 5-enolpyruvoyl- 2-oxobutanoate glutamate YdjG shikimate 3- synthase: metI L-cystathionine methylbutanoate thiolyase: metI semialdehyde amidohydrolase: semialdehyde semialdehyde semialdehyde 34 threonine shikimate 3- yl)-2-oxopropyl N-acetylornithine YdfI-P YdfI hydratase / 3- a [protein]-S- a uridine a 5' triphospho- (4-hydroxyphenyl) (2R,3S)-3- D-glucopyranose α-D-lyxopyranose phosphate chorismate shikimate 3- acetohydroxy- carbamoyl L-proline biosynthesis α pucF dehydrogenase: dehydrogenase: dehydrogenase: quercetin L-phosphinothricin an adenine in DNA 5-aminopentanoate L-tartrate 4-coumarate trans-aconitate dehydratase: phosphate phosphate dihydroxy-acid diaminopimelate aminotransferase: -D-glucosamine putative acyl- hydroxyacyl-CoA sulfanyl-L-cysteine in tRNA [mRNA] acetate isopropylmalate synthase: aroF phosphate cystathionine I (from L-glutamate) ammonia assimilation cycle III gabD putative acyl-CoA putative putative D-lyxose ilvA chorismate histidinol-phosphate acid synthase: dehydratase: epimerase: dapF phosphate superpathway 6-phosphate gabD gabD a 2,3,4-saturated fatty acid coenzyme A dehydrogenase: putative 4- DNA-adenine 3-isopropylmalate glucose 1- putative tartrate 4-coumarate aconitate chorismate chorismate L-cystathionine argD GlnKL two-component (S)-ureidoglycine dehydrogenase: a 2,3,4-saturated (3R RNA ketol synthase: aminotransferase: beta-lyase: ilvH ilvB ilvD L-homocysteine synthetase: of L-threonine phosphinothricin aminovalerate dehydrogenase: YesL (2Z)-2-aminobut- chorismate synthase: synthase: ornithine glucosamine- succinate succinate synthetase: ytcI fadN )-3-hydroxyacyl-CoA tRNA-specific hydroxyphenylacetate- methyltransferase: dehydrogenase: dehydrogenase: decarboxylase: isomerase: aroF metC carA carB glu ammonium signal transduction system ydbM quercetin 2,3- pyrophosphohydrolase: yvcI acetyltransferase: aminotransferase: gdh isomerase: PbpI 2-enoate aroF hisC alpha- 3-methyl-2- meso-diaminopimelate acetyltransferase; biosynthesis 6-phosphate [+ 4 isozymes] 3-hydroxylase: yoaI dnmA leuB ycsA padC yraM aroF cystathionine cobalamin- a 2,3,4-saturated[+ 2 isozymes] a 2,3,4-saturated (3S 2-thiouridylase: ydaE promiscuous acetolactate carbamoyl- amino-acid glutamate dioxygenase: qdoI ywnH 6 yodT D-glucono- chorismate gln L-histidinol beta-lyase: oxobutanoate oxaloacetate DctSR two-component deaminase: fatty acyl CoA )-3-hydroxyacyl-CoA trmU a 5'-phospho- (3,4-dihydroxyphenyl) an N -methyladenine 4-methyl-2- 2-hydroxy-3- chorismate anthranilate chorismate cystathionine independent 5-kinase: glu N-acetylphosphinothricin glutarate 1,5-lactone 4-vinylphenol D-xylulose cis-aconitate chorismate phosphate metC synthase: alsS meso-2,6- phosphate acetyltransferase: putative aspartate 2-oxoglutarate GlnK GlnK-P signal transduction system gamA [mRNA] acetate in DNA oxopentanoate oxosuccinate mutase: aroH synthase: / cystine beta- methionine proB glutamine enoyl-CoA semialdehyde YabQ (S)-2-aceto-2- 2-isopropylmalate isoleucine-valine diaminopimelate synthase argJ aminotransferase: glutamate (S)-ureidoglycolate chorismate synthase: metE N-acetyl-L- glucosamine- 34 YwcJ anthranilate chorismate trpE pabA chorismate histidinol promiscuous lyase / cysteine synthase: leuA decarboxylase: lysA (glutamine- glutamate synthase: synthetase: hydratase / 3- 2-protocatechuoylphloroglucinolcarboxylate CO a [protein]- a 2-thiouridine 2-iminobutanoate mutase: aroH hydroxybutanoate aminotransferase / ornithine aspB DctS-P 6-phosphate coenzyme A synthase: mutase- mutase: aroH phosphate cystathionine desulfhydrase: hydrolysing): 5-kinase: gltB gltA glnA DctS hydroxyacyl-CoA L-cysteine in tRNA acetohydroxy-acid aromatic amino acid asp deaminase: trpE pabA isozyme chorismate chorismate phosphatase: / cystine beta- patB (2S)-2- lys met pyrAA pyrAB proJ dehydrogenase: anthranilate isomeroreductase aminotransferase: γ-L-glutamyl nagB CsbX 3: aroA mutase- mutase- hisJ lyase / cysteine isopropylmalate Nucleoside and Nucleotide Degradation fadN (NADP- ilvE carbamoyl aspartate 5-phosphate a mature peptidoglycan (4-hydroxyphenyl) (2Z,4Z)-2-chloro- a 5-hydroxyuridine 34 a plant a double isozyme isozyme desulfhydrase: L-homocysteine L-ornithine ammonium gln F6P (n) a β-D glucoside c-di-GMP an acyl phosphate palmitaldehyde L-iditol 1-octanal oxamate CsbB anthranilate anthranilate histidinol dependent): ilvC 3-isopropylmalate phosphate kinase a 2,3,4-saturated a 2,3,4-saturated (meso-DAP containing) -enolpyruvate 5-hydroxyhexa- in tRNA arabinogalactan stranded DNA 3: aroA 3: aroA patB branched-chain gamma- 2-oxobutanoate phosphoribosyltransferase: trpD dehydratase: purine nucleotides degradation II (aerobic) fatty acyl CoA 3-oxoacyl-CoA 2,4-dienedioate 5 glucitol (sorbitol) type I prephenate cobalamin- (R)-2,3-dihydroxy- amino acid III: thrD glutamyl purine ribonucleosides degradation acetyl-CoA C- cyclic di-GMP tRNA ho U34 putative aldehyde putative aldehyde oxamate DNA histidinol leuD leuC GlnL-P GlnL 4-hydroxyphenylpyruvate 2-hydroxymuconate endo-beta-1,4- anthranilate N-(5-phosphoribosyl) prephenate prephenate L-homocysteine 3-methylpentanoate aminotransferase: aspartate acyltransferase: bifunctional muramidase phosphodiesterase: methyltransferase: acylphosphatase: dehydrogenase: dehydrogenase: dehydrogenase: amidohydrolase: gyrase: YhdP acetohydroxy- dehydrogenase: independent L-arginine phosphate aryl-phospho-beta- tautomerase: ywhB tautomerase galactanase: phosphoribosyltransferase: trpD -anthranilate ilvK superpathway of L-aspartate kinase AMP fadA and murein lytic pdeH trmR yflL aldY gutB aldY ywrD gyrB gyrA acid synthase: prephenate prephenate hisD methionine dihydroxy-acid 2-isopropylmaleate degradation I reductase: d-glucosidase: bglC (promiscuous): ywhB ganB YpjB prephenate prephenate and L-asparagine biosynthesis glutamyl-tRNA(Gln) 34 N-(5- phosphoribosyl cobalamin- dehydratase: (arginase pathway) I: dapG proA DctR-P DctR transglycosylase: cwlQ [+ 2 isozymes] 3-(4-hydroxyphenyl) 5'-phosphoguanylyl(3'->5') a 5-methoxyuridine keto-L-sorbose (1->4)-β-D- a negatively ilvH ilvB dehydratase: dehydrogenase: dehydrogenase: synthase: metE ornithine adenosine (3E)-2-chloro-5- a carboxylate palmitate octanoate oxalate phosphoribosyl) anthranilate dehydratase: 3-isopropylmalate amidotransferase: 5' nucleotidase: pyruvate guanosine in tRNA galactotetraose supercoiled DNA alpha- pheA tyrA histidinal independent ilvD carbamoyltransferase: aspartate glu IMP oxohex-3-enedioate -anthranilate pheA tyrA val fumarate arg L-glutamate-5- gatC gatA gatB yfkN isomerase: trpF methionine met (3S)-3-methyl-2- dehydratase: glu kinase GMP a mature peptidoglycan GlcNAc-1,6-anhMurNAc- YkuH acetolactate phosphoribosyl 3-(4- histidinol argF semialdehyde (n) D-glucopyranose a non glucosylated 3-phenyl-2- 3-(4-hydroxyphenyl) 1-(2- 3-phenyl-2- synthase: metE oxopentanoate leuD leuC arginase: II: lysC carbamoyl- inosine- (meso-DAP containing) L-Ala-γ-D-Glu-DAP-D-Ala synthase: alsS anthranilate hydroxyphenyl) dehydrogenase: acetyl-CoA D-glucose acceptor YdaL oxopropanoate pyruvate carboxyphenylamino) oxopropanoate (2R,3S)-3- L-aspartase argI phosphate 5' nucleotidase: monophosphate (S)-2-aceto-2- isomerase: trpF pyruvate hisD isoleucine-valine adenosine -1-deoxy-D-ribulose phenylalanine met isopropylmalate putative aspartate (aspartate L-aspartyl- synthase PsdSR two-component signal transduction system hydroxybutanoate 1-(2- phenylalanine tyrosine tyrosine aminotransferase / L-ornithine ComPA two-component yfkN dehydrogenase: 5-phosphate aminotransferase: aminotransferase: 4-phosphate (glutamine- carboxyphenylamino) aminotransferase: aminotransferase: aminotransferase: 3-isopropylmalate ammonia 5' nucleotidase, guaB xanthosine adenosine inosine guanosine a 5S rRNA (2-carboxy-2,5-dihydro- UTP SpsB acetohydroxy-acid indol-3- his aromatic amino acid (S)-1-pyrroline- signal transduction system a homogalacturonan uroporphyrinogen-I 2-phosphoglycolate an arylamine phenylacetaldehyde salicylaldehyde DHAP ribulose maltose glyoxal pheC hisC dehydrogenase: aspB lyase): ansB ornithine aspartate- hydrolysing): precursor 5-oxofuran-2-yl)-acetate isomeroreductase -1-deoxy-D-ribulose pheC hisC L-alanine aminotransferase: L-citrulline 5-carboxylate PsdS-N-phospho- promiscuous: UTP DinF glycerol phenylalanine leuB aminotransferase: pyrAA pyrAB PsdS XMP putative putative putative arylamine putative aldehyde putative aldehyde maltose α- glyoxal 5-phosphate phenylalanine alanine biosynthesis III ilvE semialdehyde L-histidine yutF phosphohydrolase: L-ribulokinase: (NADP- phosphate tyr pyrroline-5- ComP ComP-P uroporphyrinogen I methylglyoxal glucosidase: indol-3- tyr aminotransferase: racemization (2S)-2-isopropyl- rocD dehydrogenase: [+ 7 isozymes] α carboxymuconolactone phosphoglycolate N-acetyltransferase: dehydrogenase: dehydrogenase: rppH araB reductase: dependent): ilvC aminotransferase: synthase: trpC branched-chain asp argininosuccinate carboxylate purine nucleoside purine nucleoside purine nucleoside purine nucleoside -galacturonidase: ribonuclease decarboxylase: hemE synthase: mgsA mdxL glycerol hisC L-cysteine biosynthesis I 3-oxosuccinate L-glutamate-5- asd inosine guanosine 5' nucleotidase: decarboxylase: yrzP phosphatase: yhcW yvcN aldY aldY yvgN YcbK hisC cys amino acid reductase: phosphorylase: phosphorylase: phosphorylase: phosphorylase: lplD UMP (R)-2,3-dihydroxy- phosphate (1S,2R)-1-C-(indol-3- synthase: argG yfkN M5: rnmV (4,5-dihydro-5- an N- L(or D)-ribulose putative ala cysteine semialdehyde L-aspartate 4- proG deoD pupG pupG pupG coproporphyrinogen I glycolate phenylacetate salicylate methylglyoxal D-glucopyranose glycolaldehyde 3-methylpentanoate putative aminotransferase: asparagine oxofuran-2-yl)-acetate acetylarylamine 5-phosphate YukC synthase: yl)glycerol 3-phosphate phenylalanine D-alanine desulfurase: L-arginino- semialdehyde purine nucleoside purine nucleoside 5' nucleotidase, dihydroxy-acid phenylalanine ser ilvK synthetase: asnO 1-pyrroline-5- pyrroline-5- purine nucleoside purine nucleoside purine nucleoside purine nucleoside trpC aminotransferase: racemase: alrA iscS succinate phosphorylase: phosphorylase: promiscuous: a homogalacturonan D-galactopyranuronate a double-stranded dehydratase: (1S,2R)-1- aminotransferase: 4-methyl-2- [+ 2 isozymes] carboxylate homoserine carboxylate phosphorylase: phosphorylase: phosphorylase: phosphorylase: tryptophan aspB superpathway of L- yutF a mature 5S-rRNA NhaK C-(indol-3- aspB alanine [+ 3 isozymes] ile dehydrogenase: argininosuccinate pupG pupG pupG deoD deoD deoD oligonucleotide ilvD synthase: asparagine biosynthesis serine O- oxopentanoate dehydrogenase: reductase: yl)glycerol racemase: alrB ala asn putC lyase: argH PsdR-phosphoaspartate PsdR ComA-P ComA purine nucleoside purine nucleoside (3S)-3-methyl-2- trpA trpB phe acetyltransferase: cysE branched-chain hom proH SpoIIIAC 3-phosphate amino acid phosphorylase: phosphorylase: xanthosine α-D-ribose- phe delta-1-pyrroline- 1939 747 oxopentanoate asp amino acid pyrroline-5- 6 a 2-deoxystreptamine a uracil CDP-α-D-glucose a uracil CTP a large- tryptophan ser racemase: racX L-asparaginase arg L-homoserine deoD deoD 1-phosphate a tRNA containing N - 3-hydroxypropanal a glucuronoarabinoxylan glycolaldehyde a glucuronoxylan starch chitosan O-acetyl-L-serine aminotransferase: 5 carboxylate carboxylate antibiotic in 23S rRNA in 23S rRNA branched glucan YfkT isoleucine-valine synthase: indole D-ala hydrogen sulfide 2 (putative UTP and CTP dephosphorylation I threonylcarbamoyladenosine putative CDP- CTP ilvK dehydrogenase: reductase: 1,5-phosphopentomutase: tRNA N(6)- glucuronoarabinoxylan aminoglycoside N3'- 23S rRNA m 5 U1939 23S rRNA m 5 U747 putative aldehyde glucuronoxylan glucan 1,4-alpha- aminotransferase / trpA trpB lipoprotein): ansZ hypoxanthine guanine purine nucleoside sugar-dehydratase/ phosphohydrolase: pullulanase: chitosanase: rocA homoserine proI drm 3-hydroxypropionaldehyde endo-1,4-β- acetyltransferase: dehydrogenase: endo-1,4-β- maltohydrolase: TatCY aromatic amino acid asparagine asparagine PhoPR two-component phosphorylase: UTP threonylcarbamoyladenosine methyltransferase: epimerase: spsO methyltransferase: rppH amyX csn ser cysteine synthase: cysK exported L- kinase: thrB dehydrogenase: dhaS aminotransferase: indole tryptophan synthetase: synthetase: leu D-ribose 5- (t(6)A) xylanase: xynC yokD rlmCD CDP-4-dehydro-6- rlmCD aldY xylanase: xynC mdxD asparaginase: glu signal transduction pathway deoD a glucuronoarabinoxylan an N 3 -acetyl-2- CMP a glucuronoxylan a long-linear a chitosan asnO asnO O-acetylserine pro methylthiotransferase: mtaB a 5-methyluracil 1939 a 5-methyluracil 747 ComGA ilvE synthase: O-phospho- phosphate UTP CTP synthetase: pyrG a tRNA containing deoxy-α-D-glucose glycolate α-maltose thiol-lyase: mccA ansA xanthine guanine purine nucleoside 3-hydroxypropanoate oligosaccharide deoxystreptamine antibiotic oligosaccharide α-D-glucan fragment trpA trpB [+ 2 isozymes] [+ 2 isozymes] L-homoserine 2-methylthio-N 6 in 23S rRNA in 23S rRNA branched-chain tryptophan dehydrogenase: deaminase: phosphorylase: phosphohydrolase: putative cysteine PhoR PhoR-P threonylcarbamoyladenosine YubF amino acid asp threonine pucE pucD pucC guaD pupG rppH CTP synthase: synthase-like enzyme: ytkP aminotransferase: trpA trpB synthase: trp asn asn pyrimidine deoxyribonucleotides CTP YhgE ilvK thrC UDP xanthine dephosphorylation phosphohydrolase: cys UTP putative NTP rppH LutP ile trp thr xanthine phosphohydrolase: pyrophosphohydrolase: dehydrogenase: rppH CDP PhoP-P PhoP mutT YwzH pucE pucD pucC UMP CTP S-methyl-5'- nucleoside triphosphate phosphohydrolase: urate YtdP thioadenosine pyrophosphatase; 5' nucleotidase: yfkN rppH degradation IV septum formation 5' nucleotidase, SrtA CMP S-methyl-5'- DNA-binding protein promiscuous: yutF (multicopy associated 5' nucleotidase: yfkN thioadenosine uridine methylthioadenosine filamentation): maf 5' nucleotidase, GdpP nucleosidase: mtnN dCTP dCMP promiscuous: yutF YvbI MTR cytidine dUTPase: yosS [+ 3 isozymes] YuzJ dUTP dUMP YbfF

5-hydroxy-CTP 5-hydroxy-CMP

YpjP GanQ a ferric S-methyl- hydroxamate iron(III)- an aliphatic guanosine an a β- D-fructose L-cysteine N-acetyl-D- N-acetyl-D- a sugar ala complex petrobactin sulfonate an antibiotic chromate melibiose oligopeptide D-fructose 1-phosphate D-trehalose D-mannose G sn-glycerol phosphate glucoside 6- D-ribopyranose (S)-malate glucosamine glucosamine ammonium nitrate sucrose 6 D-ala a fluoroquinolone hypoxanthine 3-phosphate glycerol a carboxylate spermidine a xenobiotic phosphate 1-phosphate 6-phosphate 6-phosphate 6-phosphate 6-phosphate -phosphate ethidium iron(III) iron(III)- aliphatic ABC family putative S-alkyl phosphotransferase guanosine α-galactoside phosphotransferase oligopeptide hydroxamate petrobactin sulfonate multidrug chromate ribose ABC cysteine Bmr BglP FruA system (PTS) TreP ManP YdaN YwnC MaeN PbuE GamP NagP ABC YesK YuiC ComC YxkD AmtB YubD ResC NasA ConC SacP GlpT GlpF ABC YczI LytB YclK EpsC YbfE YomJ YqiH MleN YcdA YvrG YfnA HutM YcnB YkvI YvrC Pit system (PTS) YdjJ YbfB YpbD YybP YloB CsbA YndD YthQ YngC YitM YwmE YwrE CwlP YxeG Sbp YutK CpaA ComGD YhjC YopE YqhL YlbC YueC SpoIIIAF MreC YlaJ BofA YvlB YclI YqjG McpA YneN YheN YqjV Nin YkuC YnzK YvdS SpoVAC AapA YnaG YcgH YwdD YdfA GanS YhbJ NiaP YfmQ YkuT YopD YvrN EbrB YqjA YopA WalI CtaM YhcI FloT YisU YyzE GdnC YckB YecA AlaP YwjA YcsG YfiQ YhcN SscB YjbB YxaC ConB YwbG SpoIIIAD PdaC DctP SsdC YvaE Mmr CzcD OatA YxlD BkdR YhfC YabP YqhB PyrP YxaM YqfD YwoG Blt YtkC CitM BpsB BmrA ABC ABC ABC ABC efflux efflux transporter ABC fructose-specific transporter transporter lichenan-specific transporter transporter transporter transporter transporter transporter transporter N-acetyl-D- D-fructose trehalose D-mannose ala glucosamine D-ala D-fructose

a ferric N-acetyl-D- an iron(III)- a β-glucoside an aliphatic D-ribopyranose S-methyl- sucrose sn-glycerol glycerol melibiose a sugar hydroxamate a fluoroquinolone (S)-malate glucosamine ammonium nitrate a carboxylate spermidine a xenobiotic oligopeptide petrobactin sulfonate an antibiotic chromate L-cysteine guanosine 3-phosphate complex ethidium hypoxanthine Copyright SRI International 2009-2021. All Rights Reserved. This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.