CellR4 2017; 5 (5): e2439 Cancer microarray data weighted gene co-expression network analysis identifies a gene module and hub genes shared across nine types of solid cancer J.-H. Yu, S.-H. Liu, Y.-W. Hong, S. Markowiak, R. Sanchez, J. Schroeder, D. Heidt, F. C. Brunicardi Department of Surgery, University of Toledo, College of Medicine and Life Sciences, Toledo, Ohio, USA Corresponding Author: F. Charles Brunicardi, MD; e-mail:
[email protected] Keywords: Hub Gene, Gene Module, Gene Co-Expres- modules. These gene modules included BIRC5, sion Network, Microarra, Breast cancer, Glioblastoma, Me- TPX2, CDK1, and MKI67, which have previously duloblastoma, Ependymoma, Astrocytoma, Colon cancer, been shown to be associated with cancers. Gastric cancer, Liver cancer, Lung cancer, Pancreatic cancer, Conclusions: Genomic analysis revealed Renal cancer, Prostate cancer. overexpressed gene modules in nine different types of solid cancers and a shared network ABSTRACT of overexpressed genes common to all types. Objective: Microarray and next-generation se- These shared, overexpressed genes involve cell quencing techniques have revealed a series of and proliferation, supporting the idea that dif- somatic mutations and differentially expressed ferent cancers have a shared core molecular genes associated with multiple cancers. The ob- pathway. Elucidation of various networks of jective of this research was to identify networks gene modules among different types of cancers of overexpressed genes for nine common solid may provide better understanding of molecular cancers using a novel combination of systematic mechanisms for different cancers. genomic analysis and published cancer microar- ray databases. Materials and Methods: A total of twelve gene INTRODUCTION expression microarray datasets containing nine Tremendous progress has been made in genomic types of common solid cancers were obtained sequencing of cancer in the last decade.