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XXIII ISHR WORLD CONGRESS June 3 – 6, 2019 • Beijing, China

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XXIII ISHR WORLD CONGRESS June 3 – 6, 2019 • Beijing, China 1 2019 XXIII ISHR WORLD CONGRESS June 3 – 6, 2019 • Beijing, China CONFERENCE PROGRAM Healthy Heart, Happy Life 2019 XXIII ISHR WORLD CONGRESS June 3 – 6, 2019 • Beijing, China 2019 XXIII ISHR WORLD CONGRESS June 3 – 6, 2019 • Beijing, China ORGANIZER: International Society for Heart Research (ISHR) SUPPORTING ORGANIZER: International Society for Heart Research Chinese Section The Cardiovascular Society of Chinese Association of Pathophysiology President of ISHR Congress Chair of ISHR2019 Elizabeth Murphy Yi Zhu National Heart, Lung, and Tianjin Medical University Blood Institute 2019 XXIII ISHR WORLD CONGRESS June 3 – 6, 2019 • Beijing, China 4 CONTENTS INVITATION 5 ABOUT ISHR 11 ORGANIZATION 15 SCHEDULE 21 PROGRAMS 35 POSTERS 91 PRIZES & AWARDS & SPEAKERS 149 CONGRESS INFORMATION 171 TRAVEL 181 LOCAL CONTACTS 187 SPONSORS 189 5 Invitation 2019 XXIII ISHR WORLD CONGRESS June 3 – 6, 2019 • Beijing, China 6 Invitation WELCOME FROM THE ISHR PRESIDENT On behalf of the International Society for Heart Research, it is my great pleasure to welcome you to Beijing and the XXIII ISHR World Congress, an event 3-years in the making! Similar to the Olympics and the World cup that only happen every 4 years, the ISHR World Congresses only occur every 3 years and 2019 is the year for the Beijing World Congress. The triennial World Congress is the main event for ISHR International, and we’ve been working and planning for this for three years. This is shaping up to be an outstanding scientific meeting in a historic venue. The highlights of the program include the outstanding scientific program, the extensive early career activities, the poster sessions, the social interactions and a chance to connect with international colleagues. Meetings such as this do not happen without a lot of work and effort. First and foremost, thanks to Yi Zhu, Ming Xu, the local organizing committee, and the Chinese section for their tireless work on this World Congress. Thanks also to Lea Delbridge and the International program committee for putting together an outstanding series of International sponsored symposia. The ISHR is also grateful to the Early Career Investigator (ECI) committee, chaired by Kate Weeks and Chen Gao and their faculty mentors Litsa Kranias and Johannes Backs. The ECI committee has planned numerous scientific and social events and based on experience from previous World Congresses, these ECI events are a highlight of the meeting. The ISHR is also pleased to announce the formation of a new Mid-Career Investigator Committee, chaired by Davor Pavlovic. This committee has planned a number of activities at the World Congress and I encourage all Mid-Career Investigators to attend. Thanks also to Asa Gustafsson for chairing the Richard Bing Competition committee. Special thanks to Leslie Lobaugh, our Executive Secretary for all she does and to the ISHR Executive Committee for their leadership. Welcome and enjoy the Congress. Elizabeth Murphy, Ph.D. President of International Society for Heart Research Invitation 7 WELCOME FROM THE SCIENTIFIC PROGRAM COMMITTEE CHAIR Welcome to the 2019 World Congress of the International Society for Heart Research! The ISHR is among the leading societies internationally dedicated to understanding the basis for inherited and acquired diseases of the heart and vascular system, with the ultimate goal of improving clinical approaches to treatment and prevention of disease. This year's World Congress promises to report new advances in our understanding of determinants of cardiac health and disease. More than 200 speakers from all our regional sections will make oral presentations addressing the primary themes of the meeting: • New Mechanisms of Cardioprotection & Injury • New Insights into Cardiac Dysfunction • Ion Channel Mechanisms & Arrhythmias • Signalling in Cardiac Disease & Therapy • Emerging Concepts for Cardiac Regulation: Beyond the Genome • Regenerative Medicine for Heart Disease • Cardiac Metabolism • Vascular Dysfunction, Inflammation and Remodeling The Scientific Program Committee in collaboration with the Local Organizing Committee has drafted a schedule of 40 symposia that ensures that these themes are carried through the three days of the Congress. The scientific program notably features participation by investigators at early career stages: a half-day pre-Congress session involving oral presentations by Early Career Investigators, symposium presentations by faculty at ranks equivalent to assistant professor, and co-chairing of all the symposia that comprise the meeting. In all Symposia sessions selected abstracts are chosen to be highlighted as oral presentations. The schedule has been tailored to ensure that poster sessions occur during "prime time" each day. The outstanding poster from each of the three sessions selected by the judges will be recognized by a poster prize to the primary author. On behalf of the ISHR, we extend deepest appreciation to the Scientific Program Committee and the Local Organizing Committee for their thoughtful and dedicated work in bringing this World Congress to fruition. We especially thank Yi Zhu and Ming Xu, Chair and Co-Chair of the Local 2019 XXIII ISHR WORLD CONGRESS June 3 – 6, 2019 • Beijing, China 8 Invitation Organizing Committee for their leadership in hosting this meeting in Beijing and for their commitment to excellence in organizing the meeting. To the Chairs and Members of the Topic Groups we express special thanks. Their assistance in reviewing all the submitted symposia for each theme area and advising on the selection of Symposia sessions and speakers has been immensely valuable, as has been the input from the ISHR Council Executive in helping to shape the final program. To gain the full benefit of attending the World Congress, we encourage you to take part in the General Assembly and organized social activities to learn more about the ISHR and to meet colleagues from around the globe. We hope you will enjoy both the quality research presentations and the social interactions. Our best wishes, and thanks for being part of the vibrant ISHR community! Lea M. D. Delbridge Huangtian Yang Chair, Scientific Program Co-Chair, Vice Scientific Program Committee Committee Invitation 9 WELCOME FROM THE XXIII WORLD CONGRESS PROGRAM CHAIR AND CO-CHAIR Dear Colleagues and Friends, On behalf of the Local Organizing and Scientific Committees of the XXIII World Congress of the ISHR and the Chinese Section of the ISHR, it is our great pleasure to warmly welcome you to the 2019 XXIII World Congress on June 3 – 6, 2019 in Beijing, China, the first ISHR World Congress which has ever been held in China. The theme of the congress is “Healthy Heart, Happy Life”. The Scientific Committee has developed an exciting, informative, and up-to-date program with seven main topics devoted to Mechanisms of Cardioprotection and Injury, New Insights into Cardiac Dysfunction, Ion Channel Mechanisms and Arrhythmias, Signaling in Cardiac Disease and Therapy, Emerging Concepts for Cardiac Regulation: Beyond the Genome, Cardiac Metabolism and Regenerative Medicine for Heart Disease. As in previous meetings, the XXIII World Congress of the ISHR will invite the internationally distinguished speakers to participate in our congress and provides a platform for basic and clinical scientists to present their new findings, technical advancement, and therapeutic innovation. We hope that all delegates can benefit maximally through exchange of views and social networking to promote global cardiovascular health. June is the best season to visit Beijing, one of the most historical and cultural cities in China. Beijing has the largest number of cultural heritages in the world. We sincerely hope that during your stay in China, you will enjoy the experience about Chinese history, traditions, and culture, and, most importantly, the science of ISHR. We look forward to welcoming you in Beijing in June 2019. Best wishes! Yi Zhu, M.D. Ming Xu, M.D. Ph.D. Congress Chair Congress Co-Chair The President of Chinese Section The Secretary of Chinese Section of ISHR of ISHR 2019 XXIII ISHR WORLD CONGRESS June 3 – 6, 2019 • Beijing, China 10 Invitation 11 About ISHR 2019 XXIII ISHR WORLD CONGRESS June 3 – 6, 2019 • Beijing, China 12 About ISHR THE INTERNATIONAL SOCIETY FOR HEART RESEARCH History of the International Society for Heart Research •The Society started as an "International Study Group for Research in Cardiac Metabolism" in Dubrovnik in 1968; at the 1976 World Congress in Tokyo, we adopted the name "International Society for Heart Research". •Over the years, our roster has grown to include over 3,000 members. •The society has 7 international Sections (Australasian, Chinese, European, Indian, Japanese, Latin American and North American). •To date 22 World Congresses of the ISHR have been held (Dubrovnik, 1968; Gargona, 1969; Stowe. 1970; Geneva, 1971; Winnipeg. 1972; Freiburg, 1973; Quebec, 1974; Tokyo, 1976; New Delhi, 1978; Moscow, 1980; London, 1983; Melbourne, 1986; Ann Arbor, 1989; Kobe, 1992; Prague, 1995; Rhodes, 1998; Winnipeg, 2001; Brisbane, 2004; Bologna, 2007; Kyoto, 2010; San Diego, 2013; Buenos Aires, 2016) and two future World Congresses are scheduled (Beijing, 2019 and Berlin, 2022). •The Society has developed a number of prestigious awards (Peter Harris Distinguished Scientist Award, Research Achievement Award, Outstanding Investigator Award, three named Distinguished Lecture Awards and Distinguished Leader Award for Faculty; and Richard Bing Award and Travel and Poster Awards for Early-Career
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