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Incidence of Major Complications After Percutaneous Native Open Access Protocol BMJ Open: first published as 10.1136/bmjopen-2017-020891 on 27 April 2018. Downloaded from Incidence of major complications after percutaneous native renal biopsies in adults from low-income to middle- income countries: a protocol for systematic review and meta-analysis Shepherd Kajawo,1,2,3 Mothusi Walter Moloi,1,3 Jean Jacques Noubiap,4 Udeme Ekrikpo,1,5 Andre Pascal Kengne,4,6 Ikechi G Okpechi1,3 To cite: Kajawo S, Moloi MW, ABSTRACT Strengths and limitations of this study Noubiap JJ, et al. Incidence Introduction Kidney biopsy is an essential tool for guiding of major complications after clinicians towards diagnoses, treatment and determining ► To our knowledge, this will be the first systematic percutaneous native renal prognosis in renal disease. However, the procedure can be biopsies in adults from low- review and meta-analysis aiming to estimate the marred by various complications. The reported occurrence income to middle-income incidence of complications after renal biopsies in of complications varies among countries or regions and is countries: a protocol for low-income to middle-income countries. also affected by several clinical and technical factors. This systematic review and ► We aim to look at the distribution of biopsy compli- systematic review and meta-analysis aims to evaluate the meta-analysis. BMJ Open cations according to income group, providing com- incidence of major complications after percutaneous native 2018;8:e020891. doi:10.1136/ parisons that may be useful in designing strategies bmjopen-2017-020891 renal biopsy in low-income to middle-income countries to improve safety of renal biopsies in this region. (LMICs). ► Prepublication history for ► There could be heterogeneity from studies from dif- Methods and analysis We will include studies of populations this paper is available online. ferent regions, which may affect pooled estimates. from LMIC as per World Bank 2017 country list. Relevant To view these files, please visit ► The limited number of patients having renal biopsies abstracts published from 1 January 1980 to 30 December the journal online (http:// dx. doi. in some countries may affect true incident rates. org/ 10. 1136/ bmjopen- 2017- 2017 will be searched in PubMed, Cochrane, Excerpta Medica 020891). Database (Embase) and African Journals Online, without http://bmjopen.bmj.com/ language restriction. Two reviewers will independently screen, Received 30 November 2017 select studies, extract data and assess the risk of bias in each patients or assist with determination of prog- 1 Revised 13 February 2018 study. A third reviewer will arbitrate in cases of disagreements. nosis of renal disease. Since its first intro- Accepted 7 March 2018 The study-specific estimates will be pooled through a duction in 1944 and later in 1951 by Iversen random-effects model meta-analysis to obtain an overall and Brun, the procedure has provided clini- summary estimate of the incidence of major complications cians with valuable information about kidney across studies. Clinical and statistical heterogeneity will be diseases and their management despite high evaluated by Cochrane’s Q statistic. Funnel-plot analysis and 2 rates of reported biopsy complications. on September 29, 2021 by guest. Protected copyright. Egger’s test will be used to assess publication bias. Results Improvements of the technique and recent will be presented by geographical region and income group. introduction of the spring-loaded biopsy gun Ethics and dissemination This study will use published 2 data. Therefore, there is no requirement for ethical approval. have reduced some of these complications. This systematic review and meta-analysis is expected The reported occurrence of complications to inform healthcare workers and providers about the following a kidney biopsy tend to vary from occurrence of major complications following renal biopsies one region to another. A study from China, and highlight possible actions needed to improve the safety of a middle-income country, reported inci- the procedure in LMICs. The final report will be published as dence of severe bleeding to be 0.39% out of an original article in a peer-reviewed journal. Findings will also 3577 native kidney biopsies.3 However, much be presented at a conference and submitted to relevant health higher rates have been reported in other authorities. parts of the world.4–6 In Morocco, 12.3% PROSPERO registration number CRD42017077656. of patients who had undergone a percuta- neous native kidney biopsy had gross haema- For numbered affiliations see turia and 0.8% required nephrectomy after end of article. INTRODUCTIOn biopsy.4 On the other hand, a systematic Correspondence to Kidney biopsy is an essential tool for guiding review with studies mainly from high-income Dr. Shepherd Kajawo; clinicians towards the diagnosis of unex- countries found that only 0.9% of 9474 renal skajawo@ gmail. com plained renal disease, guide treatment of biopsies required red blood cell transfusion.7 Kajawo S, et al. BMJ Open 2018;8:e020891. doi:10.1136/bmjopen-2017-020891 1 Open Access BMJ Open: first published as 10.1136/bmjopen-2017-020891 on 27 April 2018. Downloaded from However, the review only included studies if renal biopsy pain after biopsy or mild haematuria resolving sponta- was performed by real-time ultrasound using automatic neously without the need for blood transfusion or other biopsy needles.7 Due to lack of such equipment in interventions. developing countries, no low-income to middle-income country (LMIC) was included in that study, making their results difficult to generalise globally. METHODS The use of automated spring-loaded biopsy devices The development of this protocol was done using the under real-time ultrasound guidance for performance of Preferred Reporting Items for Systematic reviews and renal biopsy is becoming increasingly common in many Meta-Analyses for Protocols 2015 (PRISMA-P 2015) centres.2 3 However, there are studies that have shown framework.15 that the spring-driven needles may yield similar compli- cation rates when compared with hand-driven needles.8 Criteria for considering studies for the review Similarly, while minor complications have been shown Inclusion criteria to be increased with use of free hand rather than real- 1. Studies done in LMICs reporting on complications af- time ultrasound, the incidence of major complications ter percutaneous native renal biopsies from 1 January has been shown to be similar in both techniques.9 This is 1980 to 30 December 2017 will be included. We will fo- further supported by studies reporting no difference in cus on the period after 1980 given that the techniques of renal biopsies changed substantially after 1980 with diagnostic yield or occurrence of complications between 2 16 ultrasound marked or blind biopsies.8 10 Other factors increased use of ultrasound and automatic needles. that may influence the rates of complications are the 2. We will consider relevant cohort, cross-sectional or size of needle used as some studies show that large-cal- case–control studies from LMIC. ibre needles such as the 14G needle may result in higher 3. Studies with patients 18 years and above. bleeding complications when compared with smaller Exclusion criteria needles.7 Other studies have, however, found no differ- 1. Studies reporting biopsies of tumours or kidney ence in complication rates based on size of needle used masses. for the procedure.2 11 Operator experience and training 2. Studies with fewer than 30 patients. may also affect the reported incidence of renal biopsy 3. Editorials and review articles. complications.10 Finally, despite the increasing number 4. Studies from high-income countries. of kidney biopsies being performed by radiologists, there 5. Studies reporting on kidney transplant biopsies only. is no evidence that they are safer than those performed 6. Studies with duplicate publications. In such cases, we by nephrologists.11 12 will consider only the most up-to-date and compre- This systematic review aims to summarise available data http://bmjopen.bmj.com/ hensive publication. on the incidence of reported complications in patients 7. Studies with inaccessible data even after request from undergoing percutaneous renal biopsy in LMICs. It the authors. is anticipated this will provide essential data to aid the 13 global strategy in curbing kidney disease in LMIC. This Search strategy for identifying relevant studies is important as it will provide information regarding the 1. Bibliographic database searches: We will search safety of performing renal biopsies, especially in LMICs PubMed, Excerpta Medica Database (Embase), where glomerular diseases are common causes of chronic Cochrane and African Journals Online databases 14 kidney disease and remain largely undiagnosed. for relevant abstracts. The search will be performed on September 29, 2021 by guest. Protected copyright. from 1 January 1980 to 30 December 2017 with no language restriction (table 1). Conference abstracts RESEARCH OBJECTIVES and grey literature studies will also be considered. This review aims to report on the incidence of major Dissertations and theses will be searched from complications associated with performance of renal biop- ProQuest Dissertations, Theses Online, Networked sies in LMIC. Digital Library of Theses and Dissertations and the Open Access. 2. All relevant abstracts from above sources will be scru- REVIEW QUESTION tinised and full papers downloaded from the databas- What is the incidence of major complications after renal es or journal websites. The references of these papers biopsy in adults undergoing percutaneous renal biopsy will be checked for potentially eligible studies, which in LMIC? will be assessed for eligibility. We will define major complications as any compli- cation requiring an intervention, for example blood Selection of studies deemed relevant for inclusion in the review transfusion, radiographic or surgical invasive proce- Two reviewers (SK and MWM) will independently search dure, acute renal obstruction, extended hospitalisation, the databases for relevant abstracts using agreed study septicaemia or death. Minor complications will be those inclusion and exclusion criteria.
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