Accepted Manuscript

Title: Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors

Authors: Monira Hoque, Ramzi H. Abbassi, Danielle Froio, Jennifer Man, Terrance G. Johns, Brett W. Stringer, Bryan W. Day, Marina Pajic, Michael Kassiou, Lenka Munoz

PII: S1043-6618(18)30411-0 DOI: https://doi.org/10.1016/j.phrs.2018.06.023 Reference: YPHRS 3930

To appear in: Pharmacological Research

Received date: 22-3-2018 Revised date: 13-6-2018 Accepted date: 22-6-2018

Please cite this article as: Hoque M, Abbassi RH, Froio D, Man J, Johns TG, Stringer BW, Day BW, Pajic M, Kassiou M, Munoz L, Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors, Pharmacological Research (2018), https://doi.org/10.1016/j.phrs.2018.06.023

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Hoque et al, Pharmacology of kinase inhibitors beyond the kinome

Changes in cell morphology guide identification of tubulin as the off-target for protein kinase

inhibitors

Monira Hoque1, Ramzi H. Abbassi1, Danielle Froio2, Jennifer Man2, Terrance G. Johns3, Brett W.

Stringer4, Bryan W. Day4, Marina Pajic2,5, Michael Kassiou6, Lenka Munoz1*

1 The University of , Faculty of Medicine and Health, Charles Perkins Centre, NSW 2006,

Australia

2 The Kinghorn Cancer Centre, The Garvan Institute of Medical Research, Sydney, NSW 2010,

Australia

3 Oncogenic Signalling Laboratory and Brain Cancer Discovery Collaborative, Telethon Kids

Institute, 100 Roberts Road, Subiaco, WA 6008, Australia

4 QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Australia

5 St Vincent’s Clinical School, Faculty of Medicine, University of , NSW 2010,

Australia

6 The University of Sydney, School of Chemistry, NSW 2006, Australia

*Corresponding Author

Lenka Munoz

School of Medical Sciences and Charles Perkins Centre

The University of Sydney

New South Wales 2006

Australia email:ACCEPTED [email protected] MANUSCRIPT phone: +61 2 9351 2315 fax: +61 2 8627 1606

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