Accepted Manuscript Title: Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors Authors: Monira Hoque, Ramzi H. Abbassi, Danielle Froio, Jennifer Man, Terrance G. Johns, Brett W. Stringer, Bryan W. Day, Marina Pajic, Michael Kassiou, Lenka Munoz PII: S1043-6618(18)30411-0 DOI: https://doi.org/10.1016/j.phrs.2018.06.023 Reference: YPHRS 3930 To appear in: Pharmacological Research Received date: 22-3-2018 Revised date: 13-6-2018 Accepted date: 22-6-2018 Please cite this article as: Hoque M, Abbassi RH, Froio D, Man J, Johns TG, Stringer BW, Day BW, Pajic M, Kassiou M, Munoz L, Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors, Pharmacological Research (2018), https://doi.org/10.1016/j.phrs.2018.06.023 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Hoque et al, Pharmacology of kinase inhibitors beyond the kinome Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors Monira Hoque1, Ramzi H. Abbassi1, Danielle Froio2, Jennifer Man2, Terrance G. Johns3, Brett W. Stringer4, Bryan W. Day4, Marina Pajic2,5, Michael Kassiou6, Lenka Munoz1* 1 The University of Sydney, Faculty of Medicine and Health, Charles Perkins Centre, NSW 2006, Australia 2 The Kinghorn Cancer Centre, The Garvan Institute of Medical Research, Sydney, NSW 2010, Australia 3 Oncogenic Signalling Laboratory and Brain Cancer Discovery Collaborative, Telethon Kids Institute, 100 Roberts Road, Subiaco, WA 6008, Australia 4 QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Australia 5 St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, NSW 2010, Australia 6 The University of Sydney, School of Chemistry, NSW 2006, Australia *Corresponding Author Lenka Munoz School of Medical Sciences and Charles Perkins Centre The University of Sydney New South Wales 2006 Australia email:ACCEPTED [email protected] MANUSCRIPT phone: +61 2 9351 2315 fax: +61 2 8627 1606 1 Download English Version: https://daneshyari.com/en/article/8536201 Download Persian Version: https://daneshyari.com/article/8536201 Daneshyari.com.