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Phenylpropanoids

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Phenylpropanoids Phenylpropanoids The phenylpropanoids are a diverse family of organic compounds that are synthesized by plants from the amino acids phenylalanine and tyrosine. Their name is derived from the six-carbon, aromatic phenyl group and the three-carbon propene tail of cinnamic acid, which is synthesized from phenylalanine in the first step of phenylpropanoid biosynthesis. Phenylpropanoids are found throughout the plant kingdom, where they serve as essential components of a number of structural polymers, provide protection from ultraviolet light, defend against herbivores and pathogens, and mediate plant-pollinator interactions as floral pigments and scent compounds. Concentrations of phenylpropanoids within plants are also altered by changes in resource availability. www.MedChemExpress.com 1 Phenylpropanoids Inhibitors & Modulators (+)-Columbianetin (+)-Columbianetin acetate ((S)-Columbianetin) Cat. No.: HY-N0363 ((S)-Columbianetin acetate) Cat. No.: HY-N0363A (+)-Columbianetin is an isomer of Columbianetin. (S)-Columbianetin acetate is an isomer of Columbianetin is a phytoalexin associated with Columbianetin. Columbianetin is a phytoalexin celery (Apium graveolens) resistance to associated with celery (Apium graveolens) pathogens during storage. Columbianetin exhibits resistance to pathogens during storage. excellent anti-fungal and anti-inflammatory Columbianetin exhibits excellent anti-fungal and activity. anti-inflammatory activity. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg, 20 mg (+)-Guaiacin (+)-Peusedanol Cat. No.: HY-N2247A Cat. No.: HY-N6063 (+)-Guaiacin is a compound extracted of the bark (+)-Peusedanol is a coumarin isolated from of Machilus wangchiana Chun. (Lauraceae). Peucedanumjaponicum. (+)-Guaiacin shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF) . Purity: >98% Purity: >98% Clinical Data: Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 5 mg, 10 mg (-)-Asarinin (-)-Zuonin A Cat. No.: HY-N0701 (D-Epigalbacin) Cat. No.: HY-N7394A (-)-Asarinin is a extract lignan from Zanthoxylum (-)-Zuonin A (D-Epigalbacin), a naturally armatum, mainly produced in roots of this herb. occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively. Purity: >99.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 20 mg Size: 1 mg (E)-Cinnamamide (E)-Ethyl p-methoxycinnamate Cat. No.: HY-W067479 Cat. No.: HY-N0346A (E)-Cinnamamide, the less active isomer of (E)-Ethyl p-methoxycinnamate is a natural product Cinnamamide. Cinnamamide, a derivative of the found in Kaempferia galangal with plant secondary compound Cinnamic acid. anti-inflammatory, anti-neoplastic and Cinnamamide is effectiveness as a non-lethal anti-microbial effects. chemical repellent suitable for reducing avian pest damage. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500 mg Size: 5 mg, 10 mg, 20 mg (E)-Ferulic acid (E)-Methyl 4-coumarate ((E)-Coniferic acid) Cat. No.: HY-N0060B (Methyl trans-p-coumarate) Cat. No.: HY-N2492 (E)-Ferulic acid is a isomer of Ferulic acid which (E)-Methyl 4-coumarate (Methyl is an aromatic compound, abundant in plant cell 4-hydroxycinnamate), found in several plants, such walls. as green onion (Allium cepa) or noni (Morinda citrifolia L.) leaves. Purity: 99.20% Purity: >98% Clinical Data: No Development Reported Clinical Data: Size: 10 mM × 1 mL, 100 mg Size: 1 mg, 5 mg 2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] (R,R)-Secoisolariciresinol diglucoside (Rac)-Byakangelicin ((R,R)-SDG; (R,R)-LGM2605) Cat. No.: HY-N6937 Cat. No.: HY-N0075 (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) (Rac)-Byakangelicin is a racemate of Byakangelicin is the minor isomer of Secoisolariciresinol mainly isolated from the genus Angelica. diglucoside in flaxseed. Byakangelicin is an aldose-reductase inhibitor with an IC50 value of 6.2 μM. Purity: 99.10% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg (±)-Praeruptorin A 1,4-Dicaffeoylquinic acid Cat. No.: HY-N0081 (1,4-DCQA) Cat. No.: HY-N0358 (±)-Praeruptorin A is the di-esterified product of 1,4-Dicaffeoylquinic acid (1,4-DCQA) is a cis-khellactone (CKL) and the major active phenylpropanoid from Xanthii fructus, inhibits ingredient in Peucedani Radix which consists of LPS-stimulated TNF-α production. the dried roots of Peucedanum praeruptorumDunn (Apiaceae). Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg 11-Methoxyyangonin 2'-Acetylacteoside Cat. No.: HY-N7207 Cat. No.: HY-N0026 11-Methoxyyangonin is a natural kavalactone. 2'-Acetylacteoside is a phenylethanoid glycoside isolated from Brandisia hancei, inhibits free radical-induced hemolysis of red blood cells and exhibits free radical scavenging activity. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg Size: 5 mg, 10 mg, 20 mg 2,3,4,5-Tetracaffeoyl-D-Glucaric acid 2-Hydroxy-4-methoxybenzaldehyde Cat. No.: HY-N4311 Cat. No.: HY-N0445 2,3,4,5-Tetracaffeoyl-D-Glucaric acid is a 2-Hydroxy-4-methoxybenzaldehyde, a chemical caffeoyl-D-glucaric acid derivative isolated from compound and an isomer of Vanillin, could be used the Genus Gnaphalium. to synthesis Urolithin M7. Purity: >98% Purity: 99.90% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 100 mg 3',6-Disinapoylsucrose 3'-​O-​Acetylhamaudol Cat. No.: HY-N1414 Cat. No.: HY-N6892 3',6-Disinapoylsucrose, the index component of 3'-O-Acetylhamaudol, isolated from Angelica Yuanzhi (Polygala tenuifolia Willd), possesses japonica roots, exhibits anti-tumor activity potent antioxidant activity and antidepressant through dual actions, anti-angiogenesis and effect. intestinal intraepithelial lymphocyte activation. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg, 20 mg www.MedChemExpress.com 3 3,4,5-Trimethoxycinnamic acid 3,4-Dicaffeoylquinic acid Cat. No.: HY-W012123 (3,4-Di-O-caffeoylquinic acid; Isochlorogenic acid B) Cat. No.: HY-N0057 3,4,5-Trimethoxycinnamic acid is a phenylpropanoid 3,4-Dicaffeoylquinic acid (3,4-Di-O-caffeoylquinic isolated from the roots of Polygala tenuifolia acid), naturally isolated from Laggera alata, has WILLD, with anti-stress effect, prolonging the antioxidative, DNA protective, neuroprotective and sleeping time in animals. hepatoprotective properties. Purity: 99.22% Purity: 96.44% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg 3,4-Dimethoxycinnamic acid 3-O-Caffeoylquinic acid methyl ester (O-Methylferulic acid) Cat. No.: HY-N1778 Cat. No.: HY-N4168 3,4-Dimethoxycinnamic acid (O-Methylferulic acid) 3-O-Caffeoylquinic acid methyl ester is a chemical is a monomer extracted and purified from Securidaca constituent of Pyrrosia calvata. inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway. Anti-apoptotic effects. Purity: 99.54% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg Size: 1 mg, 5 mg 4,5-Dicaffeoylquinic acid 4-Hydroxybenzoic acid (Isochlorogenic acid C) Cat. No.: HY-N0058 Cat. No.: HY-Y0264 4,5-Dicaffeoylquinic acid ( Isochlorogenic acid C) 4-Hydroxybenzoic acid, a phenolic derivative of possesses potent hepatoprotective and anti-HBV benzoic acid, could inhibit most gram-positive and effects. IC50 value: Target: Anti-hepatitis some gram-negative bacteria, with an IC50 of 160 natural produce. μg/mL. Purity: 99.98% Purity: >98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 10 mM × 1 mL, 500 mg, 1 g 4-Methyldaphnetin 4-Methylesculetin Cat. No.: HY-N4286 Cat. No.: HY-N4288 4-Methyldaphnetin is a precursor in the synthesis 4-Methylesculetin is an orally active natural of derivatives of 4-methyl coumarin. coumarin derivative, with potent anti-oxidant and 4-Methyldaphnetin has potent, selective anti-inflammatory activities. 4-Methylesculetin anti-proliferative and apoptosis-inducing effects inhibits myeloperoxidase activity and reduces on several cancer cell lines. IL-6 level. Purity: >98% Purity: 98.11% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 20 mg Size: 10 mM × 1 mL, 100 mg 4-Methylumbelliferone 4-O-beta-Glucopyranosyl-cis-coumaric acid (Hymecromone; 4-MU) Cat. No.: HY-N0187 Cat. No.: HY-N6260 4-Methylumbelliferone is a hyaluronic acid 4-O-beta-Glucopyranosyl-cis-coumaric acid is a biosynthesis inhibitor with antitumoral and natural compound isolated formn Nelumbo nucifera antimetastatic effects. Gaertn. Purity: 99.57% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg Size: 1 mg, 5 mg 4 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] 4-O-Methyl honokiol 5,7-Dihydroxy-4-methylcoumarin Cat. No.: HY-U00450 Cat. No.: HY-N4102 4-O-Methyl honokiol is a natural neolignan 5,7-Dihydroxy-4-methylcoumarin is a coumarin isolated from Magnolia officinalis, acts as a derivative from Mexican tarragon. PPARγ agonist, and inhibtis NF-κB activity, used for cancer and inflammation research. Purity: >98% Purity: 98.97% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg 6-Hydroxycoumarin 6-Methylcoumarin Cat. No.: HY-N6656 Cat. No.: HY-N1406 6-Hydroxycoumarin is a coumarin which has 6-Methylcoumarin is a synthetic fragrance widely anti-inflammatory, anti-pyretic, anti-oxidant, used in cosmetics.
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    bioRxiv preprint doi: https://doi.org/10.1101/197806; this version posted October 4, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 Scopoletin 8-hydroxylase: a novel enzyme involved in coumarin biosynthesis and iron- 2 deficiency responses in Arabidopsis 3 4 Running title: At3g12900 encodes a scopoletin 8-hydroxylase 5 6 Joanna Siwinska1, Kinga Wcisla1, Alexandre Olry2,3, Jeremy Grosjean2,3, Alain Hehn2,3, 7 Frederic Bourgaud2,3, Andrew A. Meharg4, Manus Carey4, Ewa Lojkowska1, Anna 8 Ihnatowicz1,* 9 10 1Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of 11 Gdansk, Abrahama 58, 80-307 Gdansk, Poland 12 2Université de Lorraine, UMR 1121 Laboratoire Agronomie et Environnement Nancy- 13 Colmar, 2 avenue de la forêt de Haye 54518 Vandœuvre-lès-Nancy, France; 3INRA, UMR 14 1121 Laboratoire Agronomie et Environnement Nancy-Colmar, 2 avenue de la forêt de Haye 15 54518 Vandœuvre-lès-Nancy, France; 16 4Institute for Global Food Security, Queen’s University Belfast, David Keir Building, Malone 17 Road, Belfast, UK; 18 19 [email protected] 20 [email protected] 21 [email protected] 22 [email protected] 23 [email protected] 24 [email protected] 25 [email protected] 26 [email protected] 27 [email protected] 28 *Correspondence: [email protected], +48 58 523 63 30 29 30 The date of submission: 02.10.2017 31 The number of figures: 9 (Fig.
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