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Integrating Complementary Medicine Into Cardiovascular Medicine
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Journal of the American College of Cardiology Vol. 46, No. 1, 2005 © 2005 by the American College of Cardiology Foundation ISSN 0735-1097/05/$30.00 Published by Elsevier Inc. doi:10.1016/j.jacc.2005.05.031 ACCF COMPLEMENTARY MEDICINE EXPERT CONSENSUS DOCUMENT Integrating Complementary Medicine Into Cardiovascular Medicine A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine) WRITING COMMITTEE MEMBERS JOHN H. K. VOGEL, MD, MACC, Chair STEVEN F. BOLLING, MD, FACC BRIAN OLSHANSKY, MD, FACC REBECCA B. COSTELLO, PHD KENNETH R. PELLETIER, MD(HC), PHD ERMINIA M. GUARNERI, MD, FACC CYNTHIA M. TRACY, MD, FACC MITCHELL W. KRUCOFF, MD, FACC, FCCP ROBERT A. VOGEL, MD, FACC JOHN C. LONGHURST, MD, PHD, FACC TASK FORCE MEMBERS ROBERT A. VOGEL, MD, FACC, Chair JONATHAN ABRAMS, MD, FACC SANJIV KAUL, MBBS, FACC JEFFREY L. ANDERSON, MD, FACC ROBERT C. LICHTENBERG, MD, FACC ERIC R. BATES, MD, FACC JONATHAN R. LINDNER, MD, FACC BRUCE R. BRODIE, MD, FACC* ROBERT A. O’ROURKE, MD, FACC† CINDY L. GRINES, MD, FACC GERALD M. POHOST, MD, FACC PETER G. DANIAS, MD, PHD, FACC* RICHARD S. SCHOFIELD, MD, FACC GABRIEL GREGORATOS, MD, FACC* SAMUEL J. SHUBROOKS, MD, FACC MARK A. HLATKY, MD, FACC CYNTHIA M. TRACY, MD, FACC* JUDITH S. HOCHMAN, MD, FACC* WILLIAM L. WINTERS, JR, MD, MACC* *Former members of Task Force; †Former chair of Task Force The recommendations set forth in this report are those of the Writing Committee and do not necessarily reflect the official position of the American College of Cardiology Foundation. -
Anticancer Effects of NSC‑631570 (Ukrain) in Head and Neck Cancer Cells: in Vitro Analysis of Growth, Invasion, Angiogenesis and Gene Expression
282 ONCOLOGY REPORTS 43: 282-295, 2020 Anticancer effects of NSC‑631570 (Ukrain) in head and neck cancer cells: In vitro analysis of growth, invasion, angiogenesis and gene expression RUTH HERRMANN1, JOSEPH SKAF2, JEANETTE ROLLER1, CHRISTINE POLEDNIK1, ULRIKE HOLZGRABE2 and MARIANNE SCHMIDT1 1Department of Otorhinolaryngology, University of Würzburg, D-97080 Würzburg; 2Institute of Pharmacy and Food Chemistry, University of Würzburg, D-97074 Würzburg, Germany Received September 17, 2018; Accepted September 30, 2019 DOI: 10.3892/or.2019.7416 Abstract. NSC-631570 (Ukrain) is an aqueous extract of laminin). Microarray analysis revealed the downregulation of Chelidonium majus, a herbaceous perennial plant, one of two genes encoding key regulators, including EGFR, AKT2, JAK1, species in the genus Chelidonium, which has been demonstrated STAT3 and ß-catenin (CTNNB1), all of which are involved in to selectively kill tumor cells without affecting non-malignant cell proliferation, migration, angiogenesis, apoptosis as well as cells. In the present study, the components of NSC-631570 the radiation- and chemo-resistance of HNSCC. The strongest were examined by combined liquid chromatography/mass upregulation occurred for cytochrome P450 1A1 (CYP1A1) spectroscopy (LC-MS) and the effects of NSC-631570 on and 1B1 (CYP1B1), involved in the metabolism of xenobiotics. HNSCC cell lines, as well as primary cells, were analyzed Upregulation of CYP1A1 was at least partially caused by chel- with respect to growth, apoptosis, invasion, angiogenesis erythrine and allocryptopine, as shown by RT-qPCR in two and gene expression. LC-MS identified chelerythrine and HNSCC cell lines. In addition, NSC-631570 showed a high allocryptopine as the major alkaloids of the extract. -
Graphical Abstract CG 18-1-MS
Send Orders for Reprints to [email protected] 3 Current Genomics, 2017, 18, 3-26 REVIEW ARTICLE ISSN: 1389-2029 eISSN: 1875-5488 Impact Factor: 2.43 Established Human Cell Lines as Models to Study Anti-leukemic Effects of Flavonoids BENTHAM SCIENCE Katrin Sak* and Hele Everaus Department of Hematology and Oncology, University of Tartu, Tartu, Estonia Abstract: Despite the extensive work on pathological mechanisms and some recent advances in the treatment of different hematological malignancies, leukemia continues to present a significant challenge being frequently considered as incurable disease. Therefore, the development of novel therapeutic agents with high efficacy and low toxicity is urgently needed to improve the overall survival rate of pa- A R T I C L E H I S T O R Y tients. In this comprehensive review article, the current knowledge about the anticancer activities of Received: May 11, 2015 flavonoids as plant secondary polyphenolic metabolites in the most commonly used human established Revised: November 20, 2015 Accepted: November 27, 2015 leukemia cell lines (HL-60, NB4, KG1a, U937, THP-1, K562, Jurkat, CCRF- CEM, MOLT-3, and MOLT-4) is compiled, revealing clear anti-proliferative, pro-apoptotic, cell cycle arresting, and differ- DOI: 10.2174/138920291766616080316 entiation inducing effects for certain compounds. Considering the low toxicity of these substances in 5447 normal blood cells, the presented data show a great potential of flavonoids to be developed into novel anti-leukemia agents applicable also in the malignant cells resistant to the current conventional che- motherapeutic drugs. Keywords: Antiproliferation, Apoptosis, Cell cycle arrest, Cytotoxicity, Differentiation, Flavonoids, Leukemia, Human cell lines. -
Sephadex® LH-20, Isolation, and Purification of Flavonoids from Plant
molecules Review Sephadex® LH-20, Isolation, and Purification of Flavonoids from Plant Species: A Comprehensive Review Javad Mottaghipisheh 1,* and Marcello Iriti 2,* 1 Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary 2 Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy * Correspondence: [email protected] (J.M.); [email protected] (M.I.); Tel.: +36-60702756066 (J.M.); +39-0250316766 (M.I.) Academic Editor: Francesco Cacciola Received: 20 August 2020; Accepted: 8 September 2020; Published: 10 September 2020 Abstract: Flavonoids are considered one of the most diverse phenolic compounds possessing several valuable health benefits. The present study aimed at gathering all correlated reports, in which Sephadex® LH-20 (SLH) has been utilized as the final step to isolate or purify of flavonoid derivatives among all plant families. Overall, 189 flavonoids have been documented, while the majority were identified from the Asteraceae, Moraceae, and Poaceae families. Application of SLH has led to isolate 79 flavonols, 63 flavones, and 18 flavanones. Homoisoflavanoids, and proanthocyanidins have only been isolated from the Asparagaceae and Lauraceae families, respectively, while the Asteraceae was the richest in flavones possessing 22 derivatives. Six flavones, four flavonols, three homoisoflavonoids, one flavanone, a flavanol, and an isoflavanol have been isolated as the new secondary metabolites. This technique has been able to isolate quercetin from 19 plant species, along with its 31 derivatives. Pure methanol and in combination with water, chloroform, and dichloromethane have generally been used as eluents. This comprehensive review provides significant information regarding to remarkably use of SLH in isolation and purification of flavonoids from all the plant families; thus, it might be considered an appreciable guideline for further phytochemical investigation of these compounds. -
NINDS Custom Collection II
ACACETIN ACEBUTOLOL HYDROCHLORIDE ACECLIDINE HYDROCHLORIDE ACEMETACIN ACETAMINOPHEN ACETAMINOSALOL ACETANILIDE ACETARSOL ACETAZOLAMIDE ACETOHYDROXAMIC ACID ACETRIAZOIC ACID ACETYL TYROSINE ETHYL ESTER ACETYLCARNITINE ACETYLCHOLINE ACETYLCYSTEINE ACETYLGLUCOSAMINE ACETYLGLUTAMIC ACID ACETYL-L-LEUCINE ACETYLPHENYLALANINE ACETYLSEROTONIN ACETYLTRYPTOPHAN ACEXAMIC ACID ACIVICIN ACLACINOMYCIN A1 ACONITINE ACRIFLAVINIUM HYDROCHLORIDE ACRISORCIN ACTINONIN ACYCLOVIR ADENOSINE PHOSPHATE ADENOSINE ADRENALINE BITARTRATE AESCULIN AJMALINE AKLAVINE HYDROCHLORIDE ALANYL-dl-LEUCINE ALANYL-dl-PHENYLALANINE ALAPROCLATE ALBENDAZOLE ALBUTEROL ALEXIDINE HYDROCHLORIDE ALLANTOIN ALLOPURINOL ALMOTRIPTAN ALOIN ALPRENOLOL ALTRETAMINE ALVERINE CITRATE AMANTADINE HYDROCHLORIDE AMBROXOL HYDROCHLORIDE AMCINONIDE AMIKACIN SULFATE AMILORIDE HYDROCHLORIDE 3-AMINOBENZAMIDE gamma-AMINOBUTYRIC ACID AMINOCAPROIC ACID N- (2-AMINOETHYL)-4-CHLOROBENZAMIDE (RO-16-6491) AMINOGLUTETHIMIDE AMINOHIPPURIC ACID AMINOHYDROXYBUTYRIC ACID AMINOLEVULINIC ACID HYDROCHLORIDE AMINOPHENAZONE 3-AMINOPROPANESULPHONIC ACID AMINOPYRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE AMINOTHIAZOLE AMIODARONE HYDROCHLORIDE AMIPRILOSE AMITRIPTYLINE HYDROCHLORIDE AMLODIPINE BESYLATE AMODIAQUINE DIHYDROCHLORIDE AMOXEPINE AMOXICILLIN AMPICILLIN SODIUM AMPROLIUM AMRINONE AMYGDALIN ANABASAMINE HYDROCHLORIDE ANABASINE HYDROCHLORIDE ANCITABINE HYDROCHLORIDE ANDROSTERONE SODIUM SULFATE ANIRACETAM ANISINDIONE ANISODAMINE ANISOMYCIN ANTAZOLINE PHOSPHATE ANTHRALIN ANTIMYCIN A (A1 shown) ANTIPYRINE APHYLLIC -
Premenstrual Syndrome: a Natural Approach to Management
CNI506 8/99 Vol. 5, No. 6 APPLIED NUTRITIONAL SCIENCE REPORTS Copyright © 1997 Advanced Nutrition Publications, Inc. rev. 1999 Premenstrual Syndrome: A Natural Approach to Management BY JOSEPH L. MAYO, MD, FACOG ABSTRACT: Premenstrual syndrome (PMS) is a disorder that imbalances, nutritional insufficiencies, and psychologic factors. occurs during the luteal phase of the menstrual cycle, producing A nutritional approach to PMS that takes into account the complex a diverse number of physical and emotional changes. The most interactions of all bodily systems that influence hormonal balance common symptoms of PMS include bloating, backache, breast and neuroendocrine function, with an emphasis on the liver, is tenderness, food cravings, fatigue, irritability, and depression. recommended. The nutritional factors that have been studied The timing of the appearance and disappearance of symptoms, include vitamin B6, magnesium, zinc, choline, vitamin E, and rather than the presence of specific symptoms, is of more essential fatty acids, in addition to weight management and importance in the diagnosis of PMS. The direct cause of PMS is stress reduction. Herbal therapies have also proven beneficial in unknown, although there are numerous theories relating to hormonal the management of PMS. PREMENSTRUAL SYNDROME symptoms such as bloating, breast tenderness, and headache (Table 1).3-5 These diverse symptoms may range from mild Cyclic symptoms in women of reproductive age have been to incapacitating. In some women a single symptom, such recognized for thousands of years. First appearing in the medical as depression, may predominate, whereas others may have literature in 1931 and originally termed “premenstrual tension,” several symptoms.1 this condition has been renamed “premenstrual syndrome” (PMS) in an effort to take into account the different clinical Table. -
Effects of Enzymatic and Thermal Processing on Flavones, the Effects of Flavones on Inflammatory Mediators in Vitro, and the Absorption of Flavones in Vivo
Effects of enzymatic and thermal processing on flavones, the effects of flavones on inflammatory mediators in vitro, and the absorption of flavones in vivo DISSERTATION Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the Graduate School of The Ohio State University By Gregory Louis Hostetler Graduate Program in Food Science and Technology The Ohio State University 2011 Dissertation Committee: Steven Schwartz, Advisor Andrea Doseff Erich Grotewold Sheryl Barringer Copyrighted by Gregory Louis Hostetler 2011 Abstract Flavones are abundant in parsley and celery and possess unique anti-inflammatory properties in vitro and in animal models. However, their bioavailability and bioactivity depend in part on the conjugation of sugars and other functional groups to the flavone core. Two studies were conducted to determine the effects of processing on stability and profiles of flavones in celery and parsley, and a third explored the effects of deglycosylation on the anti-inflammatory activity of flavones in vitro and their absorption in vivo. In the first processing study, celery leaves were combined with β-glucosidase-rich food ingredients (almond, flax seed, or chickpea flour) to determine test for enzymatic hydrolysis of flavone apiosylglucosides. Although all of the enzyme-rich ingredients could convert apigenin glucoside to aglycone, none had an effect on apigenin apiosylglucoside. Thermal stability of flavones from celery was also tested by isolating them and heating at 100 °C for up to 5 hours in pH 3, 5, or 7 buffer. Apigenin glucoside was most stable of the flavones tested, with minimal degradation regardless of pH or heating time. -
And East Siberian Rhododendron (Rh. Adamsii) Using Supercritical CO2-Extraction and HPLC-ESI-MS/MS Spectrometry
molecules Article Comparative Analysis of Far East Sikhotinsky Rhododendron (Rh. sichotense) and East Siberian Rhododendron (Rh. adamsii) Using Supercritical CO2-Extraction and HPLC-ESI-MS/MS Spectrometry Mayya Razgonova 1,2,* , Alexander Zakharenko 1,2 , Sezai Ercisli 3 , Vasily Grudev 4 and Kirill Golokhvast 1,2,5 1 N.I. Vavilov All-Russian Institute of Plant Genetic Resources, 190000 Saint-Petersburg, Russia; [email protected] (A.Z.); [email protected] (K.G.) 2 SEC Nanotechnology, Far Eastern Federal University, 690950 Vladivostok, Russia 3 Agricultural Faculty, Department of Horticulture, Ataturk University, 25240 Erzurum, Turkey; [email protected] 4 Far Eastern Investment and Export Agency, 123112 Moscow, Russia; [email protected] 5 Pacific Geographical Institute, Far Eastern Branch of the Russian Academy of Sciences, 690041 Vladivostok, Russia * Correspondence: [email protected] Academic Editors: Seung Hwan Yang and Satyajit Sarker Received: 29 June 2020; Accepted: 12 August 2020; Published: 19 August 2020 Abstract: Rhododendron sichotense Pojark. and Rhododendron adamsii Rheder have been actively used in ethnomedicine in Mongolia, China and Buryatia (Russia) for centuries, as an antioxidant, immunomodulating, anti-inflammatory, vitality-restoring agent. These plants contain various phenolic compounds and fatty acids with valuable biological activity. Among green and selective extraction methods, supercritical carbon dioxide (SC-CO2) extraction has been shown to be the method of choice for the recovery of these naturally occurring compounds. Operative parameters and working conditions have been optimized by experimenting with different pressures (300–400 bar), temperatures (50–60 ◦C) and CO2 flow rates (50 mL/min) with 1% ethanol as co-solvent. The extraction time varied from 60 to 70 min. -
Argemone Mexicana
Argemone mexicana General description Scientific Name with Author Argemone mexicana L. Synonyms Argemone leiocarpa Greene; Argemone ochroleuca Sweet; Echtrus trivialis Lour.; Echtrus mexicanus (L.) Nieuwl.; Argemone vulgaris Spach; Argemone versicolor Salisb.; Argemone spinosa Moench; Argemone sexvalis Stokes; Argemone mucronata Dum. Cours. ex Steud.; Argemone mexicana var. typica Prain; Argemone mexicana var. parviflora Kuntze; Argemone mexicana var. ochroleuca (Sweet) Lindl.; Argemone mexicana var. lutea Kuntze; Argemone mexicana fo. leiocarpa (Greene) G.B. Ownbey (Pires, 2009). Family Papaveraceae Vernacular Names Mexican poppy, prickly poppy, yellow thistle, Mexican thistle (En). Argémone, pavot épineux, pavot du Mexique, tache de l’œil, chardon du pays (Fr) (Bosch, 2008) Botanical Description Argemone mexicana is an annual herb, growing up to 150 cm with a slightly branched tap root. Its stem is branched and usually extremely prickly. It exudes a yellow juice when cut. It has showy yellow flowers. Leaves are thistle-like and alternate, without leaf stalks (petioles), toothed (serrate) and the margins are spiny. The grey-white veins stand out against the bluish-green upper leaf surface. The stem is oblong in cross-section. Flowers are at the tips of the branches (are terminal) and solitary, yellow and of 2.5-5 cm diameter. Fruit is a prickly oblong or egg-shaped (ovoid) capsule. Seeds are very numerous, nearly spherical, covered in a fine network of veins, brownish black and about 1 m m in diameter (Nacoulma, 1996; Bosch, 2008). 1 MEAMP – Appear Project – 75 September 2012 – August 2014 Photo LABIOCA 1. Argemone mexicana Origin and Distribution Argemone mexicana is native in Mexico and the West Indies, but has become pantropical after accidental introduction or introduction as an ornamental. -
Pacific Information Service on Street-Drugs November 1974
University of the Pacific Scholarly Commons Thomas J. Long School of Pharmacy and Health Pacific nforI mation Service on Street-Drugs Sciences 11-1-1974 Pacific nforI mation Service on Street-Drugs November 1974 School of Pharmacy Follow this and additional works at: https://scholarlycommons.pacific.edu/issd Part of the Chemicals and Drugs Commons, and the Pharmacy and Pharmaceutical Sciences Commons Recommended Citation School of Pharmacy, "Pacific nforI mation Service on Street-Drugs November 1974" (1974). Pacific nfI ormation Service on Street-Drugs. 17. https://scholarlycommons.pacific.edu/issd/17 This Article is brought to you for free and open access by the Thomas J. Long School of Pharmacy and Health Sciences at Scholarly Commons. It has been accepted for inclusion in Pacific nforI mation Service on Street-Drugs by an authorized administrator of Scholarly Commons. For more information, please contact [email protected]. PACIFIC INFORMAT· ION SERVICE Published by: School of Pharmacy University of the Pacific Stockton, California 95204 U. S. A. ON All articles may be reprinted, if used in entirety and if acknowledgement given . DRUGS Sponsored by: Beta Omega Chapter , Rho Chi Associated Students University of the Pacific • editors Gamma Nu Chapter , Kappa Psi . malone • Acknowledgement: Junior Aid of Stockton, Inc. FOUR No . 2. 3. SOLANACEOUS NARCOTICS -- A BRIEF HISTORY Varro E. Tyler* The writings of Carlos Castaneda (1) have provoked renewed interest in the subject of solanaceous narcotics, but many modern readers remain unaware of the widespread use of such plant materials as intoxicants throughout most of recorded history. Various morphological parts, particularly roots, leaves , and seeds, of species of Atropa, Datura, Duboisia, Hyoscyamus, Mandragora, and Scopolia have been chewea,-smoked or drunk by ind1viduals in all parts of the world for at least 5,000 years (2). -
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HANDBOOK of Medicinal Herbs SECOND EDITION
HANDBOOK OF Medicinal Herbs SECOND EDITION 1284_frame_FM Page 2 Thursday, May 23, 2002 10:53 AM HANDBOOK OF Medicinal Herbs SECOND EDITION James A. Duke with Mary Jo Bogenschutz-Godwin Judi duCellier Peggy-Ann K. Duke CRC PRESS Boca Raton London New York Washington, D.C. Peggy-Ann K. Duke has the copyright to all black and white line and color illustrations. The author would like to express thanks to Nature’s Herbs for the color slides presented in the book. Library of Congress Cataloging-in-Publication Data Duke, James A., 1929- Handbook of medicinal herbs / James A. Duke, with Mary Jo Bogenschutz-Godwin, Judi duCellier, Peggy-Ann K. Duke.-- 2nd ed. p. cm. Previously published: CRC handbook of medicinal herbs. Includes bibliographical references and index. ISBN 0-8493-1284-1 (alk. paper) 1. Medicinal plants. 2. Herbs. 3. Herbals. 4. Traditional medicine. 5. Material medica, Vegetable. I. Duke, James A., 1929- CRC handbook of medicinal herbs. II. Title. [DNLM: 1. Medicine, Herbal. 2. Plants, Medicinal.] QK99.A1 D83 2002 615′.321--dc21 2002017548 This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage or retrieval system, without prior permission in writing from the publisher.