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Pacific Information Service on Street-Drugs November 1974 University of the Pacific Scholarly Commons Thomas J. Long School of Pharmacy and Health Pacific nforI mation Service on Street-Drugs Sciences 11-1-1974 Pacific nforI mation Service on Street-Drugs November 1974 School of Pharmacy Follow this and additional works at: https://scholarlycommons.pacific.edu/issd Part of the Chemicals and Drugs Commons, and the Pharmacy and Pharmaceutical Sciences Commons Recommended Citation School of Pharmacy, "Pacific nforI mation Service on Street-Drugs November 1974" (1974). Pacific nfI ormation Service on Street-Drugs. 17. https://scholarlycommons.pacific.edu/issd/17 This Article is brought to you for free and open access by the Thomas J. Long School of Pharmacy and Health Sciences at Scholarly Commons. It has been accepted for inclusion in Pacific nforI mation Service on Street-Drugs by an authorized administrator of Scholarly Commons. For more information, please contact [email protected]. PACIFIC INFORMAT· ION SERVICE Published by: School of Pharmacy University of the Pacific Stockton, California 95204 U. S. A. ON All articles may be reprinted, if used in entirety and if acknowledgement given . DRUGS Sponsored by: Beta Omega Chapter , Rho Chi Associated Students University of the Pacific • editors Gamma Nu Chapter , Kappa Psi . malone • Acknowledgement: Junior Aid of Stockton, Inc. FOUR No . 2. 3. SOLANACEOUS NARCOTICS -- A BRIEF HISTORY Varro E. Tyler* The writings of Carlos Castaneda (1) have provoked renewed interest in the subject of solanaceous narcotics, but many modern readers remain unaware of the widespread use of such plant materials as intoxicants throughout most of recorded history. Various morphological parts, particularly roots, leaves , and seeds, of species of Atropa, Datura, Duboisia, Hyoscyamus, Mandragora, and Scopolia have been chewea,-smoked or drunk by ind1viduals in all parts of the world for at least 5,000 years (2). Perhaps the earliest use of such materials was their addition to the weak and unstable fermented beverages of the time in order to increase their intoxicating properties. Egyptian mythology records how the goddess Hathor set out to extermin­ ate all mankind because of its sinful nature. In order to prevent this, Deadly nightshade (Atropa belladonna) Re', king of g·ods and men , decided t o make Hathor drunk. For this purpose , he utilized a beer made from crushed barley which contained ·• ;:i\ various additives including the fruits of mandrake (Mandragora officin­ arum) . The g·oddess drank the brew and forgot all about her intention to eradicate t he human race . Fortification of beer by the addition of solanaceous herbs continued through the Middle Ages. The Chinese used stramonium (Datura stramonium) seeds · but in Europe , henbane (Hyoscyamus niger) seeds were-illore commonly employed. The widespread cultivation of henbane (Bilsenkraut in German) for t his purpose accounts for the large number of European conununi ties bearing such names as Bilsengarten , Bilsensee, Bilsen, and even Pilsen. The latter c i ty _is still closely a ssociated with t he brewing industry , and its name has become synonymous with a variety of beer. During the 16th and 17 th centuries, reg ulations and laws began to prohibit the use of henbane seed as a beer additive , and the practice gradually died out. Henbane is also intimately associated with Greek h istory , particularly with reference to the Oracles of Apollo. As a matter of fact, one of the names of the plant i s Herba Ap ollinaris or Apollo's herb (3). The t famous of these Oracles, situated at Delphi, was known as Pythia. Thorn apple (Datura} Henbane (Hyoscyamus) ed in ornate robes, t he priestess is said to have chewed "laure l" while seated on a tripod over a fissure in the earth from which a arose. During a trancelike state evidenced by her foaming mouth ive twitchings, she would respond, usually ambiguously and intermediaries, to questions concerning future events . Some ities have attributed her physiological state to the nature of the vapors, but many believe that a better explanation lies in the tion that the "laurel" leaves were henbane, the so-called herb of Pacific Information Service on Street Drugs ic Information Service on Street Drugs Volume 4 No. 1 November, 1974 5 ~ southwest, where many Indian tribes use the plant parts in adolescent or References to intoxication with solanaceous plants also occur in divinatory rites . In 1968, the Food and Drug Administration ruled that Greek mythology. Authorities (4) indicate that the wine of Circe which all products containing stramonium could no longer be sold over the counter the sorceress used to turn Ulysses' men into swine was probably fort1fiect but required a physician's prescription. This was necessitated by the with an extract of hyoscyamus. The co~on Gre~k ':'arne of the plant, Pig growing number of young people utilizing various preparations intended for bean, may indeed refer to this or to a s1rn1lar 1nc1dent. the treatment of asthma as hallucinogens. Such "underground" publications as Herbal Highs by Mary Jane Superweed (8) devote considerable space to a Solanaceous narcotics have an age-old reputation as aphrodisiacs , anct discussion of the solanaceous narcotics , indicating a widespread interest their use is vividly illustrated in the Old Testament tale of Rachel (5). in them at the present time . The dudaim which Reuben found in the field and whi?h pe~mitted Rachel ~ to fulfill her longfelt desire for children has been 1dent1f1ed as the fruit The active principles of all these plants are a series of alkaloids, of Mandragora officinarum. Kilmer (4) has pointed out that the essence principally hyoscyamine, its isomer atropine, scopolamine (also known as of this story is found in the roots of the race and probably precedes its hyoscine), and the anhydride of atropine (apoatropine) ~nd its stereoisomer, telling in Genesis by thousands of years. belladonine. Chemically, they are all tropine derivatives and esters. In medicine, atropine is used primarily for its ~ peripheral action which pro- Perhaps the most intriguing stories of these psychotropic plants con­ duces parasympathetic nervous system inhibition. It is thus effective as cern the use of henbane, belladonna (Atropa belladonna), and ~tramonium a mydriatic (dilator of the pupils of the eye), an antisialagogue (an as the active ingredients of the witches' ointments u~ed pa~t1?ularly agent stopping the flow of saliva), and an antispasmodic (a drug that during the Middle Ages (13th to 18th centuries). A w1tch w1sh1ng to fly relieves the spasms of smooth muscle) . The latter action induces relaxation to the sabbat for purposes of intercourse of peripheral blood vessels and causes a red flushing of the skin (erythema). with the devil had merely to strip her­ Local applications also induce a slight paralysis of sensory nerves, thus self naked and rub the green ointment over easing pain. Centrally, it acts to excite , then to paralyze, certain her entire body, including her anus and cerebral and medullary centers. This accounts for its narcotic or psycho­ genitals. Then striding a broom stick, tropic effects. Hyoscyamine and scopolamine are both cerebral sedatives she was ready for the magical trip. -- the latter producing a kind of "twilight sleep" which was once used extensively in medicine for its quieting and calmative effects. Conklin (6) notes that sufficient of the active alkaloids would be absorbed Effective hallucinogenic doses of the solanaceous alkaloids are large through the vaginal membranes to account enough to induce toxic effects including hyperpyrexia (high fever), for the commonly expressed sensation of accelerated pulse, mydriasis, confusion, delerium, and bizarre neurological flying. Further, the louse-bitten skin symptoms . Most users do not experience a state of well being with assoc­ of a witch would probably provide more iated (apparent) insight or understanding, but instead exhibit symptoms of than ample absorption sites. disorganization and intoxication . These are so severe that observers will often seek medical attention for the drug taker . For these reasons, the In addition to producing the sensation solanaceous narcotics are classifie d as undesirable and relatively d a ngerous of flying, such ointments probably also psychotropic agents. account for the feeling of being trans­ formed into an animal. Witches in Germany * Professor of Pharmacognosy and Dean , School of Pharmacy and Pharmacal believed themselves changed into cats, Sciences, West Lafayette IN 47907. rabbits, geese, and even werewolves by their use . Many of the witches' ointments REFERENCES contained, in addition to solanaceous plants, extracts of monkshood (Aconitum Castaneda, C., The Teachings of Don Juan , Ballantine Books, New York napellus). The initial stimulation of NY (1969) 27 pp. sensory nerve endings with associated. tingling, which was produced by its con­ Arch. exptl . Pathol. Pharmakol ., 111, 281-294 (1926). tained alkaloid, aconitine, no doubt con­ tributed to the sensation that hair or M., Econ. Bot., !• 306-316 (1947). feathers were growing from the skin. J. Pharm., 97, 4-38 (1925). The use and ,abuse of solanaceous narcotics has continued do~n to present day in both primitive and advanced societies . Austral1an anorJ.K"" ~ 14-17. ines who failed to invent the wheel and whose only domest1cated is the dog, use pituri (Duboisia hopwoodii) to provide a momentar~ G. N., Am. J . Pharm., 130, 171-174 (1958) . from their harsh environment. Schultes (7) tells us that ~oloach species) is still employed in Northern Mexico, as well as 1n the Pacific Information Service on Street Drugs Information Service on Street Drugs Volume 4 No . 1 November, 1974 6. ARF Books is now offering the first two Schultes, R. E., Science, 163, 245-254 (1969). volumes of the Proceedings of the (7) International Symposia on Alcohol (8) Superweed, M. J. , Herbal Highs , Stone Kingdom Syndicate, San Fran­ and Drug Problems held in Toronto, francisco CA (1970) 16 pp. Canada in October 1973 Editorial Addition: If further reading is desired, the following chapter THE SYMPOSIA were co-sponsored by the Addiction Re­ (37 references) is recommended.
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