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Annual Reportannual 2017 ANNUAL REPORT Canadian VIGOUR Centre THE CVC 2017 ANNUAL REPORT The future belongs to those who see it coming. Janus is the ancient Roman god of beginnings and transitions. He has historically been depicted as a god with two faces — one looking backward, and the other looking forward. To recognize the 20th anniversary of the Canadian VIGOUR Centre (CVC), we look to Janus as a symbol of our organization’s strength. The CVC continues to evolve by learning from the lessons of the past and building strategic directions for the future. Table of Contents 1 Message from the Founding Director 3 Compass 4 Vision, Mission and Core Values 5 Value Proposition of an ARO 7 Cycle of Quality 9 2017 Year in Review 14 Insights from CVC Cornerstones 19 Featured Publications 23 Faculty Presentations 27 The Next Generation of Health Researchers 33 Distinguished Visitor Series 35 Beyond 2000 Symposium 36 CVC Clinical Trials Colloquium 37 Canadian Cardiac Chronicle 39 CVC Services and Activities 41 Clinical Trials 51 ECG Core Lab 53 Biostatistical Analysis and Research Administration 55 Population Health and Economic Outcomes 57 Business Operations 59 Faculty 63 Collaborators 65 Acknowledgements Message From the Founding Director Welcome to our 2017 annual report! As we celebrate our 20th anniversary at original letter offering her a job I wrote, “Welcome aboard… It should be a great the Canadian VIGOUR Centre (CVC), it seems a propitious time to reflect on our ride!” This proved to be correct as I reflect on the remarkable transformation organization’s development, evolution and direction. Seeking inspiration on such in cardiovascular care over the past two decades. The major improvement an occasion, as I write this on a wintery Sunday afternoon, I am drawn back to my in outcomes of our patients with acute and chronic coronary disease, as well ancient Roman friend Janus. As the god of beginnings and transitions, he is often as those with heart failure, would not have occurred without research. It has represented as a god with two faces - one which looks backwards and the other been immensely gratifying for us at the CVC to be so deeply involved in this forwards. His spirit exactly captures what floods my mind on this anniversary. extraordinary and welcome shift in cardiovascular health. What gives an organization lasting value? First off, it needs to have an inspiring Yet the other face of our old friend Janus encourages us to look ahead at the key vision and mission. This should be noble and timeless so that there is no unmet needs of our patients, their families and their family’s families. There equivocation as to why it exists. Second, its core values should reflect the things are many of these. Cardiovascular disease remains the most prevalent chronic that matter to good people, namely mutual respect, unimpeachable integrity, non-communicable disease worldwide with a lifetime risk exceeding 60% of the unrelenting pursuit of quality and an outward looking and generous collaborative population. Fortunately, a remarkable array of new tools ranging from stem spirit. To attract outstanding faculty and staff, such as those who grace the cells, pharmacogenomics, precision medicine, big data and artificial intelligence pages of this report, the organization needs to have an unquenchable thirst for have emerged that promise to facilitate the search for new solutions. Recruiting innovation (often driven by dissatisfaction with the status quo), a willingness and the best and brightest young people to participate in this enterprise is the key to desire to lead and the intent to impact health policy by finding better health care our future success. solutions. Add a healthy dollop of career development strategies and presto… you have all the ingredients necessary to attract and grow a wonderful group In 2016 we identified key strategic initiatives for the organization, and we have of people who, as a synergistic team, can make great things happen! continued to refine these throughout the past year. These initiatives are rooted in our engagement in regional, national, and international collaborations, Walk with me for a moment as we travel through the genesis of a research honouring our teaching and mentoring legacy, enhancing our contributions publication that constitutes one key metric of our progress. These come from to the quality cycle of research, and leading innovations in CV research. To the faculty’s creative ideas, often in collaboration with others. Translating a galvanize these objectives the faculty and leadership convened in June 2017 research grant or protocol needs careful building and then editing by talented to explore bold ideas that would inform our future directions. An internal deep administrative staff who help give these ideas life. For ideas to be sound and dive into CVC operations has also encouraged us to set long-term targets on our feasible, they need careful planning by rigorous analysts and biostatisticians. The strategic pathway. best ideas go nowhere if there is no fuel to drive them, and so our business and finance group is critical in the budgeting and funding elements. Execution of all of We at the CVC intend to be here to continue bridging hearts and minds to this planning cannot happen without our project team, who deftly operationalize enhance cardiovascular care. I wish to acknowledge the creative expertise of all of the delicate details. Our monitors, or troops in the field in every region of Ellen Pyear, Lisa Soulard and Oksana Grant in preparing this report as well as Canada, provide needed evaluation that we are doing what we said we would do, our CVC team’s extraordinary work in 2017 about which the Co-Directors and I and if not, why not? To complete the cycle of quality, as is evident in the list of are both proud and exceedingly grateful. We hope you enjoy this annual report selected publications herein, the access to large population health data requires and would welcome any feedback, which can be directed to [email protected]. analytical sophistication and the ability to understand “big data”. Along this great journey, we engage trainees of many differing stripes, so they can learn with us Paul W. Armstrong, MD as we move forward while growing their careers and taking part in the adventure - Founding Director and the presentations and publications that follow. It has been said “Those who do not remember the past are condemned to repeat it” (George Santayana). As the Founding Director, I have made more mistakes than my two accomplished Co-Directors and three talented Associate Directors combined! Hence, I work hard on influencing us to avoid repeating too many of those as we move ahead in these exciting times. In preparing to celebrate this 20th anniversary, I recently conversed with one of our original and prior project leads about her early experience at the CVC. She reported that in my 2 Compass Cli nic nt al Vision, Mission, e Im m p p a o c l t e P and Core Values v Vision Promise o CRO e - Trusted partner Generate, translate D and disseminate knowledge li Clinical Research - Effective communicator c Organization r - Clinical relevance on novel diagnostics and y e - Scientifically robust therapeutic strategies in e - Credible results cardiovascular medicince Core Values Vision Patient’s r - Novel technologies acquired through a collaborative research Unmet - System performance Generate, translate and disseminate NeedsQuality and Integrity C measure knowledge on novel diagnosticGovernment and Engagement - Fulfill social and Pharmaceutical contract therapeutic strategies inPhilanthropic cardiovascular Aspire to the highest standard of Perform our roles in an ethical framework Industry medicine acquired throughSector Fundingcollaborative work while respecting a balanced life which enhances our reputation as honest, research to enhance the health of the perspective. Attract, mentor and retain trustworthy and responsible. Purpose citizens of Alberta, Canada, and the world. high quality colleagues and collaborators Qualitative And Quantitative Measurement to enhance cardiovascular with similar core values. Respect health for current and future generations Create an innovative, engaging and Collaboration Professional and Public Education Mission inclusive work environment, appreciative Aligned with the University of Alberta and Promote and support an outstanding team of individual differences and contributions. the Mazankowski Alberta Heart Institute that integrates a diversity of knowledge, Our workplace will be conductive to Health Economic Evaluation Operational Priorites experience, ideas, and skills supportive of personal growth and development that is L Core Values (MAHI), our mission is to: - Collaborator and site retention - Quality our mission/vision. aligned with our overall mission. e through engagement - Collaboration a - Efficient project management • Design, conduct, analyze andAcademic ARO Research Organization - Integrity Responsive Health Policy d - Early on the ground n - Respect disseminate findings arising from novel s - Maximizing return on investment o clinical research - Linking trials/registries/populations i H t • Interrogate clinical trial, registry and e a a v population health data to evaluate o outcomes, identify unmet needs and rt s n inform future basic and clinical In A s research directions nd u • I dentify, inspire and nurture the next M uo generation of health researchers i in and professionals. nd nt s Co 4 Cli nic t al en Im m p p a lo c e t v Vision P Promise
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