Assessment of Physical Sciences and Engineering Advances in Li fe Sciences and Oncology (APHELION Study) Physics and oncology/biomedical studies in Asia
June 2013 Purpose of APHELION Study • Compare U.S. R&D and status with those in Asia and Europe
• Identify the gaps and barriers in working with leading centers in Asia and Europe
• Identify the major innovations emerging abroad
• Guide U.S. research investments
• Look for opportunities for cooperation and collaboration World Technology Evaluation Center, Inc. (WTEC)
WTEC is conducting a global Assessment of Ph ysical Sciences and Engineering Advances in Li fe Sciences and On cology (APHELION), sponsored by the U.S. government.
WTEC is the leading organization in the U.S. conducting International Technology Assessments via expert review, and has conducted over 70 such studies since 1989
HTTP://WWW.WTEC.ORG/APHELION Sponsors of APHELION Study
• National Institutes of Health (NIH/NCI): – NCI Sponsor: Larry Nagahara and Nas Kuhn – NIBIB Sponsor: Christine Kelley – NIH NCI Participants: Larry Nagahara, Nas Kuhn, Sean Hanlon
• National Science Foundation (NSF): – Sponsors: Clark Cooper; Semahat Demir; Kesh Narayanan, M. C. Roco, . was conducted
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Outcomes from Workshops Establish trans-disciplinary physical sciences- ~300 extramural oncology centers participants Composed of integrated physical sciences- oncology teams Focus on theme(s) for center framework Centers led by physical scientist with senior co-investigator from oncology Merging “Perspectives”
Physical Scientist Cancer Biologist/Oncologist
How much energy is needed What cell, molecule, tissue is to do this? it? How much force does it take What changed? to cross this barrier? What ’’’s up/down regulated? Are reactions rates altered Do I see the same thing in during this process? several tumors? How much time does it take? What are the spatial effects?
Different ‘‘‘views ’’’ of the same picture Having both perspectives yields a more comprehensive (clearer) picture of what cancer is and how it functions at all levels – especially at the sub-molecular/atomic scales Delegation for the APHELION Study Site Visits
• US government sponsors and officials
• Members of Expert Panel
• WTEC staff APHELION Panelists Paul Janmey (Chair) , PhD, Professor of Physiology, School of Medicine, University of Pennsylvania;
Daniel A. Fletcher, PhD Professor, Department of Bioengineering University of California ,Berkeley;p
Sharon Gerecht, PhD, Associate Professor, Department of Chemical and Biomolecular Engineering, Johns Hopkins University;
Ross Levine, MD, Memorial Sloan -Kettering Cancer Center;
Parag Mallick , PhD, Assistant Professor, Department of Radiology, Stanford University;
Owen McCarty , PhD, Associate Professor, Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University;
Cynthia Reinhart-King , PhD, Associate Professor, Department of Biomedical Engineering, Cornell University. APHELION Expert Advisors
• Antonio Tito Fojo, M.D., Ph.D. Medical Oncology Branch and Affiliates Head, Experimental Therapeutics Section Senior Investigator Building 10, Room 12C103
• Denis Wirtz, Professor of Chemical and Biomolecular Engineering and Materials Science, Johns Hopkins University APHELION Panelists
Paul Janmey Current and past research: •Interaction between cytoskeletal and ECM stiffness Biopolymer physics •Effects of substrate mechanics of cell structure and function Cell and soft tissue •Phosphoinositide signaling for actin assembly mechanics •Fibrin-based materials for wound healing Extracellular matrix structure •Intermediate filament assembly and mechanics and signaling
Biography: Fibroblasts Myocytes Myocytes Fibroblasts Fibroblasts Professor, Physiology, Physics, Bioengineering Institute for Medicine and Engineering University of Pennsylvania New research directions Post-Doc Hematology-Oncology Unit, MGH • Signaling between integrins and HA receptors for cell proliferation and motility PhD, Physical Chemistry – Univ. Wisconsin • Mechanosensing through cadherins
AB, Philosophy, Oberlin College
Web: http:// www.uphs.upenn.edu/ime/janmey/index.html APHELION Panelists
Current and past research: •Mechanics of leukemic cells Dan Fletcher •Reconstitution of branched actin networks •Measurement of platelet contraction Cell mechanics, •Mechanics of branching morphogenesis reconstitution of the cytoskeleton, optical & force microscopy, global health technologies
Biography: Professor, Bioengineering and Biophysics, University of California, Berkeley New research directions Faculty Scientist, Physical Biosciences, Lawrence • Mechanics of breast cancer cells Berkeley National Laboratory • Mechanical regulation of actin networks • Development of infectious disease diagnostics PhD – Stanford University DPhil – Oxford University BS – Princeton University Web: http://fletchlab.berkeley.edu APHELION: Expert Panelist Current and past research: •Stem Cell Engineering •Biomaterials Sharon Gerecht •Angiogenesis and vascular biology •Hypoxia Blood vessel development and differentiation, hypoxia, Polysaccharide hydrogels, Wound healing
Blood, 2012; Biomaterials, 2012; SCTM 2013
Biography: PDMS Glass Associate Professor, Chemical and Biomolecular Engineering, Johns Hopkins University PMMA PhD – Biotechnology- Technion-Technical Institute of Israel Biomed Microdevices, 2012; Biotechnol Appl Biochem, 2012 MS – Medical Science – Tel Aviv University BA - Biology- Technion-Technical Institute of Israel New research directions • Tumor ECM • Burn and diabetic wound healing • Blood brain barrier
Web: http://www.jhu.edu/chembe/gerecht/ APHELION Panelists
Parag Mallick Current and past research: Biomarkers for diagnosis and •Markers and Mechanisms of Therapeutic Response to prognosis, Systems biology, EGFR Targeted Therapies Proteomics, Multi-scale •Models of tumor-to-circulation transmission models of cellular regulation, •ProteoWizard applications of micro-devices •Systems models of cell-state for single-cell analysis
Biography: Asst. Professor, Radiology, Bio-X, Canary Center for Cancer Early Detection Stanford University Post-Doc, Clinical Proteomics & Systems Biology New research directions – Institute for Systems Biology • Tumor evolution • Cell Biomechanics PhD, Chemistry – UCLA • Tumor Microenvironment BS, Computer Science – Washington University
Web: http://med.stanford.edu/profiles/Parag_Mallick/ APHELION Panelists
Current and past research: •Characterization of the interaction of cancer cells with the blood microenvironment Owen McCarty •Development of anti-thrombotic strategies •Role of Rho GTPases in platelet cell biology Blood cell biology, circulating tumor cells, cancer metastasis, thrombosis
Biography: Associate Professor, Biomedical Engineering Oregon Health & Science University Postdoc – Pharmacology, Oxford University New research directions PhD – Chemical Engineering, Johns Hopkins • Development of single cell imaging modalities University • Identification of thrombotic risk factors in cancer patients BS – Chemical Engineering, SUNY Buffalo
Web: www.ohsu.edu/bme APHELION Panelists
Current and past research: •Cell Migration •Cell-Biomaterial Interactions Cynthia Reinhart-King •Cellular Traction Stresses •Cellular Mechanotransduction Cancer metastasis, Angiogenesis, Atherosclerosis progression
Biography: Associate Professor, Biomedical Engineering, Cornell University PhD, Bioengineering, University of Pennsylvania New research directions SB, Chemical Engineering, MIT • Microfabricated tissue structures SB, Biology, MIT • 3D Microenvironments • Microfluidic devices for cellular studies
Web: http://cellmechanics.org APHELION Expert Advisor
Antonio Tito Fojo, M.D., Ph.D. Medical Oncology Branch and Affiliates Head, Experimental Therapeutics Section Senior Investigator Building 10, Room 12C103 10 Center Drive Bethesda, MD 20892 Phone: 301-496-2631 Fax: 301-402-1608 E-Mail: [email protected]
Biography Dr. Fojo was born in Havana, Cuba, moved to the United States with his family in 1960, and became a U.S. citizen in 1970. He received his M.D. and Ph.D. from the University of Miami. He completed 3 years of training in internal medicine at Washington University/Barnes Hospital in St. Louis, and after a year as chief resident came to the NCI as a clinical associate in the Medicine Branch, now the Cancer Therapeutics Branch. After 3 years with Drs. Ira Pastan and Michael Gottesman, he assumed the position of senior investigator in the Cancer Therapeutics Branch.
17 EXPERT ADVISOR
Denis Wirtz Johns Hopkins University Email: [email protected] Website: http://www.jhu.edu/chembe/wirtz/ he Department of Chemical and
Denis Wirtz is professor of Chemical and Biomolecular Engineering and Materials Science in the Whiting School of Engineering and a member of the oncology department at the Johns Hopkins School of Medicine. Dr. Wirtz is a recognized expert in cell and molecular biophysics and in the development of new methods grounded in physical principles, including statistical mechanics and polymer physics, to probe and establish the physical mechanisms of cell motility, intercellular adhesion, and microrheology. He is Editor-in- Chief of Cell Health and the Cytoskeleton andserves on the Editorial Boards of Biophysical Journal, Physical Biology, and Cell Adhesion and Migration . He is the founder and Associate Director of the Johns Hopkins Institute for NanoBioTechnology (INBT).
18 Scientific/Technical Topics of Interest
• Information Transfer in Cancer and other Biomedical research areas through an Evolutionary Lens • Time Domain of Cancer Metastasis and other Diseases with Therapy • Mechanics in Health and Disease • Physical Parameters of Cells, Microenvironment, and Host • Understanding Physical Emergent Properties During Pathogenesis of Disease • Heart and Lung Disease – Connections to Cancer • Physics of New Diagnostic Principles and Methods APHELION Europe Sites Visited http://wtec.org/aphelion/index.php
• FRANCE ‹Institute Curie, Paris ‹University of Paris Diderot
• GERMANY ‹Max Planck Institute (Dresden, Gottingen) ‹Dresden Technical University ‹Gottingen University ‹Technical University of Munich ‹University of Heidelberg ‹University of Leipzig ‹University of Rostock APHELION Europe Sites Visited (2)
• ISRAEL ‹Weizmann Institute ‹Technion University
• ITALY ‹University of Padua ‹University of Milan ‹European Institute of Oncology
• The NETHERLANDS ‹The Hubrecht Institute, Utrecht ‹Radboud University Nijmegen ‹The University of Leiden APHELION Europe Sites Visited (3) • SPAIN ‹University of Barcelona ‹University of Basque Country
• SWITZERLAND ‹Ecole Polytechnique Federal de Lausanne (EPFL) ‹University of Basel
• SWEDEN ‹Uppsala University ‹The Karolinksa Institute ‹The Royal Institute of Technology APHELION Asia Study Tour Delegation
Group A (Singapore, Shanghai, Taiwan, Japan) :
Paul Janmey (Chair), Daniel Fletcher*, Sharon Gerecht*, Owen McCarty*, Cynthia Reinhart- King, Nas Kuhn, Larry Nagahara *+ …
Group B (Beijing, Hong Kong, Japan):
Daniel Fletcher*, Sharon Gerecht*, Parag Mallick, Owen McCarty*, Larry Nagahara*, Sean Hanlon+ … APHELION Tentative Schedule
• Feb 2012 – Kickoff meeting • May 2012 – Visit to Europe • June 2012 – European draft reports • June 2012 – Final workshop at NIH (http://www.tvworldwide.com/events/nih/120612/) • August 2012 – Final report goal • June 2013 – Visit to Asia • July 2013 – Asian site reports • October 2013 – Draft report • November 21, 2013 – Final workshop in Washington DC • February 2014 – Final report goal APHELION Final Workshop
• To be held in Washington, D.C. on November 21, 2013
• Final workshop will be webcast from 8:00 am to 4:30 pm EDT
• Registration information for final workshop will be at http://www.wtec.org/aphelion Thank you for your cooperation in this visit!