INSIDE

2 LASKER TRIUMPH Researcher Gregg Semenza wins prestigious award for his discovery on how cells sense oxygen.

3 ZEALOUS ABOUT ZIKA New Johns Hopkins Zika Center to diagnose and treat the virus that causes brain and eye abnormalities. 5 A TALE OF ENDURING BONDS Four Suburban Hospital nurses reflect on their 147 combined years of service and friendship.

INSIGHT PRECISION MEDICINE A Johns Hopkins-developed web application A publication for the Johns Hopkins Medicine family Volume 67 • Number 9 • October 2016 predicts course of low-risk prostate cancer. Dome

From left, investigators Peter Searson, Howard Egeth and Kerry Stewart discuss their exercise and cognition study while participant Kasidet Hiranniramol paces on a treadmill. CHRIS MYERS

early every day, Peter Searson, Grants Give director of the Institute for NanoBioTechnology, leaves his Collaborations office to run between 5 and 10 miles with members of the Hopkins Harriers, a group he a Running Start helped found in 2000. University and school of medicine The midmorning exercise seems to sharpen his thinking, he says, and staves funding programs encourage researchers Noff late-afternoon drowsiness. Searson studies the blood-brain barrier. He wonders if intense exercise real- to team with experts in other disciplines. ly does improve cognition, perhaps by generating proteins that can somehow get past the brain’s protective filter. “For years, I’ve been thinking about how I could turn my interest into an inquiry,” he says. Searson got his chance in early 2015, when The Johns Hopkins University launched the Discovery Awards program. The fund encourages collabora- tive research, paying as much as $150,000 for studies led by researchers from more than one Johns Hopkins school or affiliate. The idea is to support- ex plorations that can lead to larger, grant-funded studies, says Denis Wirtz, the university’s vice provost for research. Within days of the Discovery announcement, Searson contacted Kerry Stewart, exercise physiologist in the school of medicine, and Howard Egeth, cognitive psychologist in the Krieger School of Arts and Sciences. Fast forward to the summer of 2016. The three investigators are comparing Learn more about the strategic priority notes as they stand in the Clinical Research Unit at Johns Hopkins Bayview for biomedical (continued on page 4) discovery online at hopkinsmedicine.org/ strategic_plan .

Published by Johns Hopkins Medicine Marketing and Communications CHIEF PERSPECTIVES PEOPLE Exciting Developments Lasker Award Winner Everywhere Johns Hopkins researcher wins prestigious award for RONALD R. PETERSON insights into how cells sense oxygen. PRESIDENT, JOHNS HOPKINS HEALTH SYSTEM regg semenza, whose discoveries on how cells respond to low oxygen EXECUTIVE VICE PRESIDENT, levels could result in treatments for illnesses ranging from cancer to diabetes, JOHNS HOPKINS MEDICINE is among three researchers to receive the 2016 Albert Lasker Basic Medical Re- search Award. ere in East Baltimore, Last month, The Lasker Foundation recognized Semenza, director of the Vas- the change of leader- Gcular Biology Program in the Institute for Cell Engineering, along with co-winners William ship at The Johns Kaelin Jr. of Dana-Farber Cancer Institute and Peter Ratcliffe of Oxford University, for the Hopkins Hospital has “discovery of essential pathways by which human and animal cells sense and adapt to the pres- Hgenerated much excitement— ence of oxygen.” They shared an award of $250,000. and rightly so. Dr. Redonda Semenza, 60, is best known for his groundbreaking discovery of hypoxia-inducible factor 1, Miller’s appointment to succeed or HIF-1, the protein that switches genes on and off in cells in response to low oxygen levels. me as president of the hospital This finding, along with his additional work clarifying the molecular mechanisms of oxygen on July 1 was widely applauded, regulation in cells, has far-reaching implications in understanding the impact of low oxygen and she quickly has demon- levels in cancer, diabetes, coronary artery disease and other conditions. strated tremendous promise as His research paves the way for developing drugs that could kill cancer cells by cutting off a vibrant, engaging new leader. the supply of oxygen a tumor needs to grow or could increase the ability of HIF-1 to ensure From my vantage point as that tissues affected by such conditions as arterial disease can survive on low president of the Johns Hopkins oxygen levels. Health System, I can report that The Lasker Awards recognize the contributions of scientists, cli- The Johns Hopkins Hospital isn’t alone when it comes to excit- nicians and public servants who have made major advances in ing new developments. All of our medical centers are either the understanding, diagnosis, treatment, cure or prevention of completing or embarking upon noteworthy ventures. Here are human disease. They are among the most prestigious awards a few highlights: in science. At Johns Hopkins Bayview Medical Center, preliminary A native of New York City, Semenza earned his M.D./ plans are now underway for construction of a much-needed Ph.D. from the University of Pennsylvania and completed new patient tower. Johns Hopkins Bayview is the only major his internship and residency in pediatrics at Duke Univer- hospital in the Baltimore area without a complement of all- sity. He began his career at Johns Hopkins in 1986 with a private inpatient beds. We need to change that. An integral postdoctoral fellowship in medical genetics. part of the planning process includes important discussions A member of the McKusick-Nathans Institute of Genetic about how to better coordinate clinical services across the two Medicine and Johns Hopkins Kimmel Cancer Center, Se- academic campuses. Examples of such joint planning efforts menza has authored more than 400 research articles and book include maternal and child services, neurosciences, orthopaedic chapters, which have been cited more than 100,000 times. He is surgery, and other surgical and medical disciplines. editor-in-chief of the Journal of Molecular Medicine. In the national capital region, great things are happening at both Sibley Memorial Hospital and Suburban Hospital. To learn more and to see a video, visit hopkinsmedicine.org/dome. Sibley’s magnificent, beautifully designed, 200 all-private-bed medical center—appropriately named the New Sibley—opened in September after three years of construction. Budgeted to cost around $240 million, it likely will come in under budget— something that rarely happens these days! It introduces Johns Hopkins cancer care to the region with a new branch of the Johns Hopkins Kimmel Cancer Center, including expanded PATIENT- AND FAMILY-CENTERED CARE inpatient oncology units, a pediatric radiation oncology unit and plans for installation of proton beam therapy. In addition, it has a new Women’s and Infants’ Services Department, with 19 private, special care nursery bassinets, an orthopaedic unit with Meet the a rehabilitation gym, and integrated technology to improve the patient and visitor experience. At Suburban, we are planning for a comprehensive physi- New Sibley cal redevelopment of the medical center and its campus. All of this will be overseen by Suburban’s new president, Jacqueline Long-awaited expansion offers “Jacky” Schultz, a 30-year veteran of the health care industry, with the last 11 years at Suburban. She served splendidly as improvements in patient- interim president for nine months before the Suburban board centered care and state-of-the- made her appointment permanent in July. Just as the academic division is immersed in joint program art technology. planning, our National Capital Region Planning Committee, consisting of Sibley and Suburban board members, executive he new patient tower of Sibley Me- leadership, and representatives from Johns Hopkins Medicine, is morial Hospital, which opened on Sept. also focusing intensely on determining which medical center is 26, features 200 all-private rooms and the best suited to provide various services. Sidney Kimmel Cancer Center, which of- Howard County General Hospital has been inundated with fers expanded space for medical oncology, new patients due to the closure of services at Laurel Regional Tincluding 34 private infusion rooms and an inpatient Hospital. Howard County General is now approaching full oc- oncology unit. In addition, the new building also con- cupancy on a day-to-day basis. Plans are underway to signifi- tains the region’s only radiation oncology program ded- cantly increase bed capacity and address the substantial need to icated to children. Other improvements that are part of improve psychiatric facilities. the 475,000-square-foot hospital expansion include two The last time I visited Johns Hopkins All Children’s Hospi- floors of women’s and infants’ services and an ortho- tal in St. Petersburg, Florida, I looked out of President Jonathan paedic unit with a rehabilitation clinic. The new patient Ellen’s office window and got a bird’s-eye view of the major tower will be LEED Gold Certified and includes many research building currently under construction there. Five years green features, including the largest green roof of any ago, the desire of the hospital’s trustees to become an academi- health care facility in Washington, D.C. cally driven medical center was a main reason behind their The Emergency Department, which opened last year, agreement to join Johns Hopkins Medicine. Now, an exciting, has 28 new treatment rooms; CT and MRI capabilities beautiful new research and education facility will soon be part within and adjacent to the new ED; and specialized, of their campus—fulfilling that long-held wish. fixed decontamination showers to handle exposure to radiation, chemical or biological contaminants.

To learn more, go to hopkinmedicine.org/dome.

2 • DOME • OCTOBER 2016 PATIENT- AND FAMILY-CENTERED CARE Johns Hopkins Comprehensive Care Center for Zika Virus Opens he new johns hopkins zika cen- ter will diagnose and treat pregnant women, newborn babies, and men and women of all ages with the mos- quito-borne and sexually transmitted Tvirus. Scientists will assess long-term effects of the virus as well as new approaches to its prevention and treatment. Developed under the leadership of the Wilmer Eye Institute, the center is composed of providers and staff members from many adult and pediatric departments and divisions within Johns Hopkins Medicine and the Bloomberg School of Public Health. “This breadth gives us the ability to diagnose, treat and help prevent further proliferation of disease,” says ophthalmologist and center director William May of the Wilmer Eye Institute. Zika virus is known to cause microcephaly, a birth defect that affects the brain, but is also reported to cause eye abnormalities in more than half of babies infected with the illness. The Wilmer Eye Institute and its faculty members will diagnose and, in many cases, treat people of all ages for eye diseases associated with Zika virus, including cataracts. Adults and children worldwide can be referred During a recent trip to Brazil, to the center by outside physicians or through ophthalmologist William May several Johns Hopkins departments and divisions, meets a baby affected by Zika including emergency medicine and maternal-fetal –Photo courtesy of medicine. Patients can also call the Wilmer Eye Altino Ventura Foundation. Institute to schedule an appointment. —Kim Polyniak

INTEGRATION Epic Experts Share What Works anny Lee had an idea. It was 2013, and Epic had just gone live for Johns Hopkins Community Physi- cians locations, including DOdenton, where Lee is an internist and the office medical director. He wanted the electronic medical record system to better help clinicians meet Accountable Title: Transport Goes Mobile Title: MyChart eCheck-In Title: MyChart OpenNotes Care Organization standards. ACOs, like the Johns Hopkins Medicine Alliance for Presenter: Tara Waldrop, Epic Presenters: Kelly Cavallio, Epic Presenters: Howard Levy, inter- Patients, provide coordinated care across application coordinator operations administrator nist and Epic physician builder specialties to Medicare patients. Steven Klapper, Epic project Evangeline Schindler, Epic ap- So Lee, who leads Epic development for lead plication coordinator community physicians, created a dash- Technology: An app called Rover board that prompts providers to schedule assigns and manages hospital and track preventive care supporting transport, such as taking a patient Technology: With eCheck-In, Technology: OpenNotes gives ACO standards, including screenings for from the Emergency Department patients can confirm appoint- patients access to the clinical breast cancer, depression and fall risk. to a hospital bed, or from a bed to ments, update insurance, verify notes written by their provid- As a result, ACO metrics improved the operating room. Transport- medications and fill out question- ers. Patients can find the notes across ambulatory sites. Breast cancer ers use mobile devices to accept naires up to a week before their through a hyperlink in MyChart. assignments and indicate when appointments. The system gener- screenings for appropriate patients rose they are in progress and com- ates a bar code that patients bring from 59 percent to 64 percent, for exam- When and Where plete. Rover provides the patient’s to their appointments. : Voluntary ple. Depression screenings went from 47 name, date of birth, weight, and pilot began at The Johns Hopkins percent to 74 percent, and fall risk screen- locations of pickup and drop-off. Hospital in July 2015. Where and When ing jumped from 24 percent of eligible A comment field has room for : The e- Check-in feature went live in patients to 70 percent. information, such as whether a Results: Through March 15, A few months ago, Lee took his success patient can communicate verbally June 2015 for patients who use MyChart. 2016, 8,342 patients received story to the Expert Group Meeting, an or needs oxygen. notes from 77 providers, and 941 annual event hosted by the Epic Systems patients opened them. At least Corporation at its headquarters in Ve- Results Where and When: Rover was : About 400 patients per one patient caught an error in the rona, Wisconsin. day use the system, which im- notes, which was subsequently The weeklong conference attracts introduced at Johns Hopkins Bay- view Medical Center in 2015. proves accuracy and saves time for corrected. Doctors believe the Epic designers and users from across the office staff and patients. system improves communication country, who share ideas and give talks with patients and helps build a about their experiences with Epic. Lee’s Results: Transport time dropped more comprehensive patient re- presentation, “Epic Tools to Meet Every six minutes because transporters cord. ACO Metric,” was among 26 given by have information with them and Johns Hopkins Medicine experts. Here no longer have to find and use are three others: computers in the hospital. —Karen Nitkin

DOME • OCTOBER 2016 • 3 BIOMEDICAL DISCOVERY

Grants Give Collaborations a Running Start (continued from page 1)

Medical Center. Study participant Ka- puter scientist Dale Roberts, biomedi- sidet Hiranniramol, a school of medicine cal engineer Jorge Otero-Millan, and research assistant, sweats as he walks on otolaryngologists Michael Schubert and a treadmill, breathing into a tube that Bryan Ward; and with Daniel Reich and measures his oxygen intake. Heart moni- Collin Broholm, two physicists from the tors are on his chest, a blood pressure Krieger School of Arts and Sciences who cuff on his arm. Blood analysis and cog- are experts in magnetic fields. nition tests will follow. Together, they are designing high- Hiranniramol will be given one min- powered magnets that painlessly stimu- ute to list as many words as he can that late the motion detectors of the inner ear, start with a given letter. He will watch mimicking the mechanism that causes shapes and colors flash on a computer vertigo. The group is now seeking fund- screen and try to identify what changes ing to build the magnets, which should from one appearance to the next. He will help researchers better understand and tell blue from green, even when the word eventually treat the debilitating condi- green is printed in blue, and the word tion. blue is printed in green. Zee says he values collaboration be- The Johns Hopkins University’s Office cause investigators from other disciplines of the Provost is giving $5 million a year “see things from their own vantage to collaborations like this one and to points, bringing new insights and ap- early-career faculty members in support proaches to the illnesses of our patients.” of innovative research directions through Searson, too, was eager to tap new the Catalyst Awards. perspectives. When he contacted Egeth School of medicine researchers can and Stewart, “he wasn’t specific at all,” also apply for Discovery Fund Synergy says Egeth, an expert in memory and More Than One Way to Fund a Study and Innovation Awards, established in attention. “He just said, ‘Let’s study the 2014 by the Johns Hopkins Medicine effects of exercise on cognition.’” 1. Johns Hopkins Discovery Award: Grants of up to $100,000 and up to $150,000 for studies led by investigators from at least two of the Research Council. Synergy grants of Their study combines their areas of university’s schools or affiliates (bit.ly/JHDiscovery) up to $100,000 support research with expertise. Searson is analyzing partici- at least one investigator in the school of pants’ blood for proteins released during 2. Johns Hopkins Catalyst Award: Grants of up to $75,000 for medicine. Single-investigator projects exercise. Stewart designed strength and investigators with three to 10 years of faculty experience (bit.ly/JHCatalyst) can win Innovation Award support of up cardio tests. And Egeth created a series 3. School of Medicine Discovery Fund Synergy Awards: Grants of up to $50,000. of cognitive challenges sensitive enough to $100,000 for collaborative research with at least one investigator in the “We wanted to incentivize creative, to measure exercise-induced changes. school of medicine (bit.ly/SOMDiscoveryFund) innovative, at-the-edge discovery,” says They decided to recruit up to 75 4. School of Medicine Discovery Fund Innovation Awards: Grants of Antony Rosen, vice dean for research, participants, measure their fitness, and up to $50,000 for innovative projects led by a single school of medicine who helped create the Synergy and Inno- divide them into groups for moderate, investigator (bit.ly/SOMDiscoveryFund) vation program. intense and no exercise. Research assis- Synergy winners in 2015 include neu- tants would draw blood and administer rologist David Zee, who has studied and cognition tests one hour, two hours and treated inner ear and balance disorders 24 hours later. for decades. He teamed with school of In July 2015, the exercise and cogni- medicine colleagues, including com- tion study became one of 24—out of 217 applicants—to win the first batch of Dis- covery Awards. The researchers are using new, Wirtz says it seems to be working. pathologist Timothy Amukele and Ap- “EVEN IF THEY DON’T the $100,000 to hire research assistants, “Putting a little bit of money on the plied Physics Laboratory engineer Robert GET THE AWARD, work out details of the study and pay table encourages interactions between Chalmers. Together, they are creating volunteers $75 for each of three visits. disciplines,” he says. “A lot of faculty a system of drones to deliver blood and THEY STILL MET AND “We probably could not have gotten members have told us the awards pushed other biological materials for testing and DISCUSSED THE PLANS a grant from an outside source because them to meet and to put together excit- transfusions. Four sites—two in Africa TOGETHER.” we had no track record on this research,” ing, more complex projects. Even if they and two in the United States—are nearly —DENIS WIRTZ says Egeth. “The Discovery Award is seed don’t get the award, they still met and ready for testing, and the work has gener- money.” discussed the plans together.” ated funding and interest from several Although the grant program is still Also winning $100,000 in 2015 were foundations, Amukele says. In July 2016, a second round of Dis- covery Awards grants gave $100,000 to 20 projects and $150,000 to four. Re- cipients included hematologist Linzhao Cheng of the school of medicine and Catalyst Awards Give Early Research a Boost malaria expert David Sullivan of the Cardiologist Chiadi Ndumele recently led a study showing that people who are Bloomberg School of Public Health. They obese are more likely to suffer from heart failure. But hearts are funny things. are using their $100,000 for research that That same obesity also seems to keep people with heart failure alive. could lead to human red blood cells that Ndumele, who joined the school of medicine faculty in 2011, is using a are genetically engineered to be resistant Catalyst Award grant to try to understand why thin people with heart fail- to malaria. ure are more likely to die than overweight people with the same condition. Before the grant, the two would talk The Catalyst Awards program, launched by The Johns Hopkins Univer- from time to time. “The funding lets us sity in 2015, gives grants of up to $75,000 for research led by investigators accelerate the interaction,” says Sullivan. who have been full-time faculty members between three and 10 years. The Back in the Clinical Research Unit, goal is to support exploratory research during a critical time in their career, Stewart is explaining to his fellow investi- paving the way for future grant-funded studies. gators how he uses exercise tests, strength The first round of awards went to 37 early-stage Johns Hopkins research- ers. In 2016, 34 faculty members from across the institution, including Ndumele, exercises and body scans to measure the received Catalyst Award funding. physical fitness of participants. Now that Ndumele’s study will examine echocardiograms and 1,193 metabolic biomarkers for the study is underway, the three agree to morbidly obese patients before they undergo bariatric surgery and after the surgery meet once a month for updates. prompts weight loss. The goal is to better understand the mechanisms that connect obesity Searson grins. “I want to start seeing and heart failure—eventually leading to improved prevention and treatment. the results,” he says. “That’s the exciting “This kind of institutional support to help us in our journey toward understanding is part.” huge,” Ndumele says. “When I’m ready to apply for an independent investigator grant, I —Karen Nitkin can say I received this award and performed this work.” —KN Learn more at hopkins medicine. org/dome.

4 • DOME • OCTOBER 2016 PEOPLE

In Sickness and in Health With 147 years of combined service, four Suburban Hospital nurses share friendships forged in good times and bad. atch Diane Harris and Ruthie Reutlinger- Dudley Cin a rare down moment, and you’ll likely find the Suburban Hospital nurses ooh-ing and ahh-ing over photos of their grandchildren. The two, along with Karen Sgueo and Ruthie Sokolove, have forged deep bonds while working together in the pre- operative care unit, where they make sure each patient is ready for the operating room. In a hospital with about 1,800 employees, including some 600 nurses, friend- ships flourish in every unit. But these nurses are unusual because they’ve known each other for decades. Together, they share 147 years of Sub- urban Hospital nursing expe- rience, seven grandchildren, at least 15 holiday parties and hours of conversations. “We’ve been through deaths, births, weddings—all the major life events,” says From left, Suburban Hospital nurses Reutlinger-Dudley, whose Diane Harris, Ruthie Reutlinger-

mother, Juanita Reutlinger, Dudley, Ruthie Sokolove and Karen MIKE CIESIELSKI was also a Suburban Hospital Sgueo share smiles and memories. nurse. Sgueo, 66, is Suburban’s longest- clocks in at 35. Harris, 61, joined women lean on each other, like serving nurse; she donned a jaunty the staff 25 years ago. “WE’VE BEEN when a parent dies or a relative cap and starched white miniskirt The four laugh easily, tease THROUGH needs surgery. for her first day of work in 1970. freely, kiss cheeks and pat shoul- The worst was when Harris’ son Reutlinger-Dudley, 62, boasts 41 ders. Their conversation gets even DEATHS, BIRTHS, died. Some people stayed away, years on the job. Sokolove, 65, more animated as they describe WEDDINGS—ALL unsure what to say or do. Not an annual holiday party THE MAJOR LIFE Sgueo, who had lost her son to a for the 10 nurses and three heart condition when he was 6. technicians in their unit. EVENTS.” “That same day, Karen showed Reutlinger-Dudley, known —RUTHIE REUTLINGER-DUDLEY up at my front door with a basket as Ruthie D., mixes her of fresh muffins,” says Harris, her famous cosmos. Sokolove’s eyes blurring. The two grab each husband cooks the brisket, other’s hands as they remember. even though he, like other “We’ve built a community,” says spouses, is not invited. Sokolove, unit manager and the The friendships are solid only full-timer of the four. “We things, built over time. Hard know we can count on each other work, shared jokes and fond through thick and thin.” memories are the bricks. The —Karen Nitkin mortar forms when these

IN BRIEF It’s Flu Shot Time Johns Hopkins Medicine faculty, staff, states that nasal spray vaccines have medical students, postdocs and residents not been effective during the past two who provide direct patient care or who seasons. For all member organizations work in a patient area are required to except Johns Hopkins All Children’s get an annual flu vaccination. Starting Hospital, the deadline to comply with Oct. 3, most Johns Hopkins Medicine the mandatory vaccination policy is Dec. employees will be able to get a free 6; the deadline to request a medical or flu shot at one of the health system’s religious exemption from the policy is on-site vaccination clinics, as well as at Nov. 1. The compliance deadline for participating Walgreens. Johns Hopkins Johns Hopkins All Children’s is Nov. 16, physicians and providers will not offer and the exemption deadline is Oct. 14. FluMist, nor accept it in lieu of a shot, For more information and for a list of because an advisory from the Centers dates, times and locations for flu shots, ISTOCK for Disease Control and Prevention visit bit.ly/jhmflushots

DOME • OCTOBER 2016 • 5 PATIENT- AND FAMILY-CENTERED CARE

Practice makes perfect for, from left to right, simulation specialist Adam Dodson and pediatric anesthesiologists Hal Shaffner and Rahul Koka. CHRIS MYERS CPR in the OR Employing a “rapid-cycle deliberate practice” simulation model, Johns Hopkins pediatric anesthesiologists shave critical seconds off the time from cardiac arrest to cardiopulmonary resuscitation. ediatric anesthesiologist simulation every two years. In his mind, simulations are also highly individualized Rahul Koka recalls the cardiac “THE ARGUMENT I that’s not often nor repetitive enough. to the anesthesiologist leading the code, arrest and resuscitation of a WOULD MAKE IS “The argument I would make is that’s who may believe, for example, that resus- good friend in the operating not how violinists or pianists practice— citation can go quicker with the code cart room at a community hospital. THAT’S NOT HOW they do it over and over and over again,” on his right side rather than his left. PWhat impressed him was the speed at VIOLINISTS OR PIANISTS says Koka. “That’s how we’re aiming to The results? Koka’s goal was chest which anesthesiologists began chest practice.” compression within 10 seconds—and compressions and defibrillation, so PRACTICE—THEY DO IT Importing in part the CPR protocol defibrillation within 30 seconds—of much so that the experience spurred OVER AND OVER AND pioneered in the Johns Hopkins pediatric arrest. Anesthesiologists participating him to develop ways to improve resus- OVER AGAIN,” SAYS intensive care unit, Koka increased the in the initiative were able to reduce the citation in the pediatric OR, including frequency, length and depth of the simu- average time to compressions from 150 a new quality improvement initiative at KOKA. “THAT’S HOW lations, adding pre-training simulations seconds to 2 seconds and the average the Johns Hopkins Children’s Center. WE’RE AIMING TO and debriefing surveys to assess the team’s time to defibrillation from 232 seconds “This project is personal for me,” says confidence and performance in conduct- to 31 seconds. Koka. “Despite some tremendous odds PRACTICE.” ing the code. Simulation training sessions An added value of the QI initiative is —RAHUL KOKA working against my friend, he was suc- that took 30 minutes in the past now last its potential for influencing CPR simula- PEDIATRIC ANESTHESIOLOGIST cessfully resuscitated due to a very good an hour or more. tions at other children’s hospitals. Greater protocol for cardiopulmonary resuscita- “We’d simulate an arrest, do compres- frequency and intensity of simulations, tion.” sions, then talk about what we did, and says Koka, will help fight the learning Johns Hopkins has very good arrest that was it,” says Koka. “But for this decay that typically occurs six to eight protocols for both adults and children, a 10 percent drop in survival. “You need quality improvement protocol, that’s just months after a training simulation. Koka says, but for an intervention where good chest compressions quickly.” the beginning, the first third of a simula- “Ideally, you want to be repeating this seconds can make the difference between In that regard, Koka’s “rapid-cycle tion training. We go in, do the simula- about every six months using different life and death, there’s always room for deliberate practice” simulation stresses tion, debrief, and then we do it again and techniques and expanding it beyond at- improvement. It’s well-documented in the repetition, repetition and more repetition. again until we get it right.” tending physicians,” says Koka. “I would literature, Koka explains, that for every Under Pediatric Advanced Life Support, Getting it right means nuancing the like to include nurse anesthetists as well.” minute without chest compression or or PALS, protocols, Koka notes, current protocol to chip seconds off of the time to —Gary Logan defibrillation after cardiac arrest, there is CPR practice recommends didactics and chest compression and defibrillation. The

IN BRIEF Support the 2016 Johns Hopkins Medicine Special Town Meeting on United Way Campaign: Oct. 13–Dec. 16 Community Engagement This year’s annual United Way make your contribution Johns Hopkins Medicine’s commitment Meeting on community engagement. campaign, beginning Thursday, and to learn more about to the communities it serves was built Live-streamed to all member organiza- Oct. 13, is focused on improving United Way programs. You into the founding of The Johns Hopkins tions, the event will feature updates life for families and their com- can choose where your Hospital and has continued through on Johns Hopkins Medicine’s current munities. By participating in the dollars go, such as the gen- countless programs and initiatives in the and planned community programs, annual campaign, you can help ensure that eral United Way fund or a specific initiative decades since. Mark your calendars to and an expanded Q&A session to children succeed in school, and that families supporting your community or county, like join Paul Rothman, dean of the medical allow faculty members, staff members have access to healthy meals, resources for the Johns Hopkins Neighborhood Fund. faculty and CEO of Johns Hopkins Medicine, and students to provide feedback and ask employment and a place to call home. You can also direct your donation to a on Thursday, Oct. 20, from 12:30 to questions about the institution’s community Visit hopkinsmedicine.org/unitedway to 501(c)(3) charity of your choice. 1:30 p.m. in Hurd Hall for a special Town engagement efforts.

6 • DOME • OCTOBER 2016 PEOPLE Howard County General Hospital Helps Heal Ellicott City Hiring displaced workers is one way the hospital supports the flood-devastated community.

lex garza was pan-roasting halibut and plating shrimp when the rain began. Nearly 6 inches fell in two hours, creating a furious brown river that took two lives and destroyed Ellicott City’s historic downtown. When cars began float- Aing past Tersiguel’s French Country Restaurant, Garza and the other cooks stopped working to make sure the gas was off and customers were safe. The July 30 flood shuttered Tersiguel’s and about 90 other businesses, putting more than 450 people out of work. When the water receded, Garza walked home carrying his 9-inch cu- linary-grade knife and wondering where he would work next. Less than a month later, Garza, 29, started a full-time job as a line cook for Howard County General Hospital. “Being able to serve others goes a long way in the healing process,” he says. Recruitment specialist Ana Liesch says she hopes to hire other locals who lost jobs due to the storm, billed as a once-in-a- thousand-year event. “We are providing support any way we can,” says hospital President Steven Snelgrove. “It may mean jobs; it may mean asking for volunteers to serve those who are doing the physical labor. It may mean moral support.” In mid-August, as heat and humidity soared to dangerous heights, the hospital set up first-aid tents along Main Street. Nurses treated people for high blood pressure, exhaustion and dehydration during two days of emotional cleanup. On Oct. 1, a group of hospital volunteers was scheduled to clear debris from a litter-filled portion of the Patapsco River. Nonprofits, individuals and governments have all stepped forward to begin the process of restoring downtown Ellicott City. The hospital, meanwhile, has been fulfilling its role as healer. It also gave $10,000 from its community funding pro- gram to the Ellicott City Partnership, which is directing 100 Alex Garza, left, is cooking again, thanks percent of donations toward rebuilding efforts. to Howard County General Hospital —Karen Nitkin recruitment specialist Ana Liesch.

IN BRIEF

Stylish Shopping Benefits Patient Care

High-fashion altru- ism continues: For the 49th straight year, The Women’s Board of The Johns Hopkins Hospital will host its fall A Move for the Better Best Dressed Sale and Boutique. The Three Johns Hopkins Community Physicians practices previously located in Wyman Park free event takes have moved to a more patient-centered and spacious facility just a few blocks away. Now place from Friday, located at 2700 Remington Ave., in Baltimore, the primary care practices occupy a new Nov. 4, through 30,000-square-foot area on the second floor. Internal medicine, pediatrics, and gynecology Sunday, Nov. 6, and obstetrics are unified in one space, along with lab services, encouraging a team approach at the Evergreen to delivering health care. Another design innovation, created to improve the patient experi- Carriage House, ence, calls for ushering patients to examining rooms as soon as they are checked in for their 4545 N. Charles appointments rather than requiring them to sit in a traditional waiting room area. The Rem- St. Hours are: Nov. 4, from 9 a.m. to 6 p.m.; Nov. 5, from 9 a.m. to ington Row development project also features first-floor retail space and 108 apartments. 4 p.m.; and Nov. 6, from 11 a.m. to 3 p.m. A special preview party will take place on Nov. 3 from 4 to 8 p.m. It costs $55 in advance and $65 at the door. Racks and shelves will be packed with new and gently used men’s and women’s Voyage to Better Health designer, dressy, casual and vintage clothes and accessories. Over the years, the sale has A Woman’s Journey, Johns Hopkins Medicine’s annual conference on women’s raised millions of dollars to support patient health topics, will take place on Saturday, Nov. 5, from 8:15 a.m. to care at The Johns Hopkins Hospital. This year, 4:30 p.m. at the Hilton Baltimore, 401 W. Pratt St. Now in its 22nd year, proceeds will help fund medical equipment the event brings together Johns Hopkins Medicine’s top experts to discuss ad- and scholarships to the schools of medicine vances in medicine. Participants can attend seminars on a variety of subjects, and nursing, among other projects. Learn including the benefits of vitamins and other food supplements, chronic pain, more at womensboard.jhmi.edu or call 410- sleep disorders and hot topics in aging research. Speakers include Redonda 955-9341. Miller, the first female president of The Johns Hopkins Hospital, and plastic surgeon Kofi Boahene. The conference, which includes lunch, costs $130 per person. Discounts for employees and full-time students are available. To learn more and to register, call 410-955-8660 or visit hopkinsmedicine.org/ awomansjourney.

DOME • OCTOBER 2016 • 7 WHO / WHAT PICTURE THIS

Lasker Award Gregg Semenza, Open Enrollment M.D., Ph.D., whose Reminder discoveries on how cells respond to low oxygen levels could result in treatments for illnesses ranging from cancer to diabetes, is among three researchers to receive the 2016 Albert Lasker Basic Medical Research Award. The Lasker The open enrollment Foundation recognized Semenza, period for selecting health along with co-winners William insurance and benefits Kaelin Jr., M.D., of Dana-Farber runs from Oct. 17 through Cancer Institute and Peter Rat- Oct. 31 for employees cliffe of Oxford University, for the of The Johns Hopkins “discovery of essential pathways Hospital and Health System Corporation, by which human and animal cells Johns Hopkins Bayview sense and adapt to the presence of Medical Center, Johns oxygen. Semenza is best known Hopkins Community for his groundbreaking discovery Physicians, Johns Hopkins of hypoxia-inducible factor 1, or HealthCare, Johns HIF-1, the protein that switches Hopkins Home Care Group, Sibley Memorial genes on and off in cells in re- Hospital and Howard sponse to low oxygen levels. He is County General Hospital. a member of the Institute for Cell Open enrollment for other ILLUMINATING A NEW CHAPTER Engineering, the McKusick-Na- Johns Hopkins Medicine Alphie Rahman, a clinical nurse specialist at including nurses from The Johns Hopkins thans Institute of Genetic Medi- organizations: Johns Johns Hopkins Bayview Medical Center, lights Hospital, Howard County General Hospital cine and the Johns Hopkins Kim- Hopkins All Children’s a ceremonial lamp to signal an auspicious and Johns Hopkins Bayview. It is a chapter of mel Cancer Center. Hospital, Oct. 12 through beginning for the Indian American Nurses the National Association of Indian Nurses of Oct. 26; Suburban Association of Maryland, a group she founded America. “Our hope is to have a professional Hospital, Oct. 31 through New Senior Director for and for which she serves as president. body where we mentor each other and Nov. 18; and school of Dedicated to supporting professional develop leadership qualities,” Rahman says. the Johns Hopkins Health medicine, Oct. 21 through development and networking for nurses and The group also performs community service System Nov. 8. Staff members nursing students of Indian origin and heritage, projects in Baltimore. Learn more and see will receive a newsletter the group has more than 50 members, more photos at hopkinsmedicine.org/dome. Angelo Mojica, announcing the rates and Ph.D., has been any changes to benefits. named the senior di- rector of food and Women by the Filipina Women’s the Year Award. Hatzigeorgalis culinary services for Network (FWN). The honor, in joined the Johns Hopkins Bay- the Johns Hopkins Blue Distinction Center for Knee the FWN’s Builder Award catego- view staff 18 years ago as a certi- Health System. Moji- and Hip Replacement. Earlier this ry, recognizes Domingo-Snyder’s fied medical assistant and became ca will provide leadership to all year, Howard County General exceptional impact at a large a nurse nine years ago. workplace. food services departments and be Hospital was designated a Blue Laura Jaweed, Dome responsible for integration of the Distinction Center for Maternity EAST BALTIMORE D.P.T., has been food service operations among Care, a new honorific under the named manager of Published 10 times a year for members of Blue Distinction Specialty Care the Johns Hopkins Medicine family by each of the six affiliate hospitals. Steven Cohen, M.D., director the Joint Replace- Marketing and Communications. He will oversee the health sys- Program, which recognizes health of medical education for the pain ment Program. In tem’s food service supply chain care facilities nationwide for dem- The Johns Hopkins University management division at the Johns her new role, she will School of Medicine initiative and work collaboratively onstrating expertise in delivering Hopkins University School of work closely with the The Johns Hopkins Hospital across the system to improve pa- quality care safely, effectively and Medicine, recently received the joint replacement surgeons, ad- Johns Hopkins Bayview Medical Center cost-efficiently. Howard County General Hospital tient satisfaction and employee distinguished service award from ministrators and the director of Johns Hopkins HealthCare engagement for food services op- the Military Health System Re- nursing. Jaweed previously served Johns Hopkins Home Care Group erations. Prior to joining Johns Quality Innovation Johns Hopkins Community Physicians search Symposium. Cohen, a re- as the director of physical therapy Sibley Memorial Hospital Hopkins, Mojica was responsible Awards tired U.S. Army colonel, received and occupational therapy at Bos- Suburban Hospital for all food service and clinical Johns Hopkins All Children’s Hospital Howard County General Hos- the award in the research category ton Children’s Hospital. nutrition operations at the Uni- pital and Johns Hopkins Bay- of pain management. The honor Editor versity of North Carolina at Cha- SUBURBAN HOSPITAL Linell Smith view Medical Center have re- recognizes individuals who have pel Hill. contributed significantly to the Contributing Writers ceived the Virginia Health Qual- Greta Cuccia, R.N., advancement of military health Neil A. Grauer, Gary Logan, Damon Runyon Awards ity Center Quality Innovation B.S.N., C.E.N., Judy F. Minkove, Karen Nitkin, Award for improving patient care system research. Kim Polyniak, Katelynn Sachs, clinical director of Linell Smith Daniel Goldman, Ph.D.; Mi- and reducing hospital-acquired Richard Huganir, the Emergency De- chael Koldobskiy, M.D., Ph.D.; infections in 2015. Granted to Ph.D., professor and partment, has re- Copy Editors Cara Rabik, M.D., Ph.D. Abbey Becker and , all the top 10 percent of hospitals director of the De- ceived the first Judy F. Minkove oncology fellows, each received a in Maryland and Virginia, the partment of Neuro- DAISY Nurse Leader Designer four-year, $248,000 award to sup- award is based on patient safety science, has been Award for creating a compassion- Max Boam port their basic science research. and service scores. The evalua- elected president of ate environment in which skillful Photographer One award is a Damon Runyon tions used data from the Targeted the Society for Neu- care thrives. The award, presented Keith Weller Cancer Research Foundation Assessment for Prevention, devel- roscience, the world’s largest orga- by Suburban Hospital’s nursing Dalal Haldeman, Ph.D., M.B.A. Fellowship. The two others are oped by the Centers for Disease nization of scientists and physi- council on professional develop- Senior Vice President, Damon Runyon-Sohn Pediatric Control and Prevention, and the cians devoted to understanding ment, was created by the DAISY Johns Hopkins Medicine Fellowship Awards. Goldman, Hospital Consumer Assessment the brain and nervous system. (diseases attacking the immune Marketing and Communications who studies the process of protein of Healthcare Providers and Sys- Huganir is also director of the system) Foundation, established Send letters, news and story ideas to: synthesis, often misregulated tems. Editor, Dome Kavli Neuroscience Discovery In- in 1999 by the family of a termi- Johns Hopkins Medicine in cancer, received the Runyon stitute and co-director of the nally ill patient whose nursing Marketing and Communications research foundation fellowship. Comprehensive Brain Science Institute. care touched them greatly. 901 S. Bond St., Suite 550 Koldobskiy, who studies the way Stroke Center Baltimore, MD 21231 Lillie Shockney, Phone: 410-502-9602 cancer cells rely on epigenetic Marketing and Email: [email protected] modifications, the chemical marks Johns Hopkins Bayview Medical R.N., M.A.S., pro- Communications that modify a gene’s expression Center has been issued a full fessor and adminis- Read Dome online at Comprehensive hopkinsmedicine.org/news/publications/ without changing its genetic se- designation as a trative director of the Johns Hopkins Medicine and dome Stroke Center quence, and Rabik, who examines by the Maryland Johns Hopkins the Johns Hopkins Health Sys- © 2016 The Johns Hopkins University and how mutations in the WT1gene Institute for Emergency Medical Breast Center, re- tem have received a total of 27 The Johns Hopkins Health System Corporation. result in acute myeloid leukemia, Services Systems (MIEMSS). This cently received The Digital Health Awards—rang- each received a Runyon-Sohn five-year designation comes after Folio: Top Women in Media ing from Gold to Silver, Bronze fellowship. Runyon was a famed the Medical Center’s successful Award. It recognizes her role as and Merit—from the Health newspaperman and author who completion of a MIEMSS editor-in-chief of the Journal of Information Resources Center. Comprehensive Stroke Center site Oncology Navigation and Survivor- The recognitions honored online died of cancer in 1946. The Sohn Follow Johns Hopkins Medicine Conference Foundation was survey. ship, as well as her work for other publications, articles, videos and founded in 1995 and is dedicated journals, her books and her online other informational materials. The Facebook: to the treatment of pediatric can- Filipina Women’s writing. center is a national clearinghouse f facebook.com/JohnsHopkinsMedicine cer and other childhood diseases. Network Award for professionals who work in Twitter: JOHNS HOPKINS t It honors the memory of Ira Sohn, Eloiza Domingo- consumer health fields. twitter.com/HopkinsMedicine an investment trader on Wall BAYVIEW MEDICAL Snyder, director of YouTube: Street, who died of cancer at 29. CENTER yt diversity, inclusion youtube.com/user/ Shannon Hatzi- Blue Distinction Center and cultural compe- JohnsHopkinsMedicine tency for Johns Hop- georgalis, R.N., a Honors kins Medicine and labor and delivery CareFirst BlueCross BlueShield the Johns Hopkins nurse, has received has designated Johns Hopkins Health System, was named one of Johns Hopkins Bay- Bayview Medical Center as a the 100 Most Influential Filipina view’s 2016 Nurse of

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