Neuromodulation in Experimental Animal Models of Epilepsy
Neuromodulation in Experimental Animal Models of Epilepsy Stefanie Dedeurwaerdere Promoter: Prof. Dr. Paul Boon Co-promoter: Prof. Dr. Walter Verraes Ghent University Neuromodulation in Experimental Animal Models of Epilepsy Stefanie Dedeurwaerdere Thesis submitted to fulfill the requirements for the degree of Doctor in Medical Sciences Promoter: Prof. Dr. Paul Boon Co-promoter: Prof. Dr. Walter Verraes Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology Nothing in life is to be feared It is only to be understood Marie Curie Table of contents Chapter 1: General introduction 5 Chapter 2: General methodology 23 Chapter 3: Efficacy of levetiracetam 43 Dedeurwaerdere,S., Boon,P., De Smedt,T., Claeys,P., Raedt,R., Bosman,T., Van Hese,P., Van Maele,G. and Vonck,K. (2005) Chronic levetiracetam treatment early in life decreases epileptiform events in GAERS, but does not prevent the expression of spike and wave discharges during adulthood. Seizure 14(6), 403-411. Chapter 4: Efficacy of vagus nerve stimulation 61 Dedeurwaerdere,S., Vonck,K., Claeys,P., Van Hese,P., D'Have,M., Grisar,T., Naritoku,D. and Boon,P. (2004). Acute vagus nerve stimulation does not suppress spike and wave discharges in "Genetic Absence Epilepsy Rats from Strasbourg". Epilepsy Res 59, 191-198. Dedeurwaerdere,S., Vonck,K., Van Hese,P., Wadman,W., Boon,P. (2005) The acute and chronic effect of vagus nerve stimulation in "Genetic Absence Epilepsy Rats from Strasbourg" (GAERS). Epilepsia 46(Suppl 5), 94-97. Dedeurwaerdere,S., Gilby,K., Vonck,K., Delbeke,J., Boon,P. and McIntyre,D.C. Vagus nerve stimulation does affect memory in Fast rats, but has both pro-convulsive and anti-convulsive effects on amygdala kindled seizures.
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