TLR3 Controls Constitutive IFN-Β Antiviral Immunity in Human Fibroblasts and Cortical Neurons
TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons Daxing Gao, … , Jean-Laurent Casanova, Shen-Ying Zhang J Clin Invest. 2021;131(1):e134529. https://doi.org/10.1172/JCI134529. Research Article Immunology Infectious disease Graphical abstract Find the latest version: https://jci.me/134529/pdf The Journal of Clinical Investigation RESEARCH ARTICLE TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons Daxing Gao,1,2,3 Michael J. Ciancanelli,1,4 Peng Zhang,1 Oliver Harschnitz,5,6 Vincent Bondet,7 Mary Hasek,1 Jie Chen,1 Xin Mu,8 Yuval Itan,9,10 Aurélie Cobat,11,12 Vanessa Sancho-Shimizu,11,12,13 Benedetta Bigio,1 Lazaro Lorenzo,11,12 Gabriele Ciceri,5,6 Jessica McAlpine,5,6 Esperanza Anguiano,14 Emmanuelle Jouanguy,1,11,12 Damien Chaussabel,14,15,16 Isabelle Meyts,17,18,19 Michael S. Diamond,20 Laurent Abel,1,11,12 Sun Hur,8 Gregory A. Smith,21 Luigi Notarangelo,22 Darragh Duffy,7 Lorenz Studer,5,6 Jean-Laurent Casanova,1,11,12,23,24 and Shen-Ying Zhang1,11,12 1St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA. 2Department of General Surgery, The First Affiliated Hospital of USTC, and 3Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. 4Turnstone Biologics, New York, New York, USA.
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