Pyridoxal-5-Phosphate Vitamin B6 in Coenzyme Form

Douglas Laboratories® Product Data

DESCRIPTION increase their intake of vitamin B6. Pyridoxal-5-Phosphate tablets, provided by Douglas Laboraratories®, contain 50 mg of pure pyridoxal-5- FORMULA (PYP) Each tablet contains: phosphate, a metabolite of vitamin B6. Pyridoxal-5-Phosphate...... 50 mg FUNCTIONS SUGGESTED USE The biological functions of vitamin B6 (pyridoxine) are accomplished by its coenzyme form, pyridoxal-5- One tablet daily, or as directed by physician. phosphate. Pyridoxal-5-phosphate’s actions mainly involve the metabolism of amino acids and other SIDE EFFECTS nitrogen compounds. In the liver, pyridoxal-5- No adverse effects have been reported. phosphate is essential for glucose production from amino acids through its role as a coenzyme for the STORAGE transaminase enzymes. Pyridoxal-5-phosphate is Store in a cool, dry place, away from direct light. also needed in the liver and muscles to access stored Keep out of reach of children. glycogen for glucose production, and to synthesize niacin from the amino acid tryptophan. In red blood REFERENCES cells, pyridoxal-5-phosphate is needed for Baum M, Cassetti L, Bonvehi P, Shor-Posner G, Lu Y, Sauberlich H. hemoglobin synthesis, and regulation of oxygen Inadequate dietary intake and altered nutrition status in early HIV-1 infection. Nutrition 1994;10:16-20. affinity. Moreover, cell receptivity to steroid Brattstrom L, Stavenow L, Galvard H, et al. Pyridoxine reduces hormones is influenced by pyridoxal-5-phosphate. cholesterol and low-density lipoprotein and increases antithrombin III In the nervous system, pyridoxal-5-phosphate is activity in 80-year-old men with low plasma pyridoxal 5-phosphate. needed for synthesis of several neurotransmitters, Scand J Clin Lab Invest 1990;50:873-877. including serotonin (from tryptophan), taurine, Brophy MH, Siiteri PK. Pyridoxal phosphate and hypertensive disorders dopamine, norepinephrine, histamine, and gamma- of pregnancy. Am J Obstet Gynecol 1975;121:1075-1079. Dalery K, Lussier-Cacan S, Selhub J, Davignon J, Latour Y, Genest J, Jr. aminobutyric acid (GABA). Many experimental and Homocysteine and coronary artery disease in French Canadian subjects: clinical observations support the fact that dietary Relation with vitamins B12, B6, pyridoxal phosphate, and folate. Am J vitamin B6 is required to maintain normal nervous Cardiol 1995;75:1107-1111. system function. Deijen JB, Van der Beek EJ, Orlebeke JF, Van den Berg H. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance Along with vitamin B12 and folic acid, pyridoxal-5- phosphate is involved in single carbon metabolism, and mental effort. Psychopharmacology (Berl) 1996;109:489-496. Driskell JA. Vitamin B-6 requirements of humans. Nutr Res and is necessary for maintaining normal plasma 1994;14:293-324. homocysteine levels. Elevated plasma homocysteine Ferroli CE, Trumbo PR. Bioavailability of vitamin B-6 in young and may be an independent risk factor for the older men. Am J Clin Nutr 1994;60:68-71. development of cardiovascular disease. Also, due to Fortin LJ, Genest J, Jr. Measurement of homocyst(e)ine in the prediction its involvement in single carbon metabolism, of arteriosclerosis. Clin Biochem 1995;28:155-162. pyridoxal-5-phosphate assists in maintaining normal Kretsch MJ, Sauberlich HE, Skala JH, Johnson HL. Vitamin B-6 immune function. requirement and status assessment: Young women fed a depletion diet followed by a plant- or animal-protein diet with graded amounts of vitamin B-6. Am J Clin Nutr 1995;61:1091-1101. INDICATIONS Manore MM, Vaughan LA, Carroll SS, Leklem JE. Plasma pyridoxal 5'- Pyridoxal-5-Phosphate tablets may be a useful phosphate concentration and dietary vitamin B-6 intake in free-living, nutritional adjunct for individuals who wish to low-income elderly people. Am J Clin Nutr 1989;50:339-345. Naurath HJ, Joosten E, Riezler R, Stabler SP, Allen RH, Lindenbaum J.

(continued on reverse) Effects of vitamin B12, folate, and vitamin B6 supplements in elderly hyperhomocysteinemia in humans. J Nutr 1994;124:1927-1933. people with normal serum vitamin concentrations. Lancet Ubbink JB. Vitamin nutrition status and homocysteine: An atherogenic 1995;346:85-89. risk factor. Nutr Rev 1994;52:383-387. Ribaya-Mercado JD, Russell RM, Sahyoun N, Morrow FD, Gershoff Ubbink JB, Serfontein WJ, Becker PJ, de Villiers LS. Effect of different SN. Vitamin B-6 requirements of elderly men and women. J Nutr levels of oral pyridoxine supplementation on plasma pyridoxal-5'- 1991;121:1062-1074. phosphate and pyridoxal levels and urinary vitamin B-6 excretion. Am J Robinson K, Mayer EL, Miller DP, et al. Hyperhomocysteinemia and Clin Nutr 1987;46:78-85. low pyridoxal phosphate - Common and independent reversible risk Van den Berg M, Franken DG, Boers GHJ, et al. Combined vitamin B6 factors for coronary artery disease. Circulation 1995;92:2825-2830. plus folic acid therapy in young patients with arteriosclerosis and Ubbink JB, Vermaak WJH, Van der Merwe A, Becker PJ, Delport R, hyperhomocysteinemia. J Vasc Surg 1994;20:933-940. Potgieter HC. Vitamin requirements for the treatment of

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