2017 Spring Meeting Final Program

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2017 Spring Meeting Final Program PROGRAM BOOK ENAR 2017 SPRING MEETING with IMS and Sections of ASA March 12–15, 2017 Washington Hilton, Washington, DC ENAR 2017 TABLE OF CONTENTS SPRING MEETING 4 Welcome & Overview with IMS and Sections of ASA 6 Acknowledgements March 12–15, 2017 10 Special Thanks Washington Hilton, Washington, DC 11 Washington, DC Highlights 13 Presidential Invited Speaker 14 Short Courses 17 Tutorials 19 Roundtables 22 Program Summary 30 Scientific Program 112 Abstracts & Poster Presentations 331 Washington Hilton Floor Plan It is my great pleasure to welcome you to the Such a comprehensive, well-planned ENAR Meeting is only 2017 ENAR Spring Meeting! To those who may made possible by the efforts of a well-organized, hard-working, be attending your first ENAR, I extend a special collaborative team. To those who have planned, contributed welcome to you and I hope that you will come to to and organized the program, to those managing the meeting love the Spring Meeting and all that ENAR has to logistics, to our exhibitors, vendors, sponsors and volunteers – offer so much that you will not only return for many my sincere thanks to each one of you! Your individual and future meetings, but will become highly engaged collective efforts are critical to the success of the meeting! in the organization! We'd love to have you! Scientific Program: Through the leadership of Program The 2017 ENAR Spring Meeting will convene at Chair Nandita Mitra (University of Pennsylvania) and Associate the Washington Hilton near the vibrant neigh- Chair Andrea Foulkes (Mount Holyoke College) coordinating borhoods of Dupont Circle, Adams Morgan and the contributions from many of you, the Program Committee Kalorama in the heart of Washington DC. has assembled a top-notch scientific program. With broad Committee representation, including representatives from 15 The four-day meeting – March 12–15, 2017 – WELCOME! ASA sections and 4 ENAR at-large members, the invited pro- will host students, researchers and practitioners gram features a broad spectrum of topics for researchers and from every professional sector, from places large and small, practitioners alike! The sessions cover a wide range of topics from for-profits and not-for-profits, those who are junior pro- such as, data sciences (big data), precision medicine, genom- fessionals, senior professionals and everything in between, ics, clinical trials, neuroimaging, biomarkers, health policy, all connected by our common interests in biometry as well as electronic health records, and epidemiology. The IMS invited our honed computational and quantitative skills! Continuing program, organized under the direction of IMS Program Chair in ENAR’s strong tradition, the meeting will offer numerous Judith Lok (Harvard T.H. Chan’s School of Public Health) also opportunities throughout the Scientific and Educational Pro- features 9 complementary sessions continuing in the tradition grams to learn state-of-the-art research methods and software, of promoting synergies between the societies in crafting the to hear about interesting and impactful applications to many invited program. areas in the life sciences, to meet new people, to connect job seekers with employers, to expand professional networks, and Poster presentations will, once again, be a vibrant part of the to reconnect with friends and colleagues. Additionally, there scientific program. In addition to contributed and invited post- will be opportunities to thumb through the latest textbooks and ers, the 2017 ENAR Spring Meeting will continue contributed have hands-on demonstrations of new software from exhibitors oral poster sessions (first featured in the 2015 meeting), in and vendors who have partnered with ENAR. which presenters will be able to give a two-minute eleva- tor-speech on the highlights of their posters. Monday, March13 4 ENAR 2017 SPRING MEETING | Final Program will feature the thematically grouped, contributed oral poster In addition to the Program Committee, I would like to extend sessions. These will feature two invited posters from well-known a special thanks to members of the Educational Advisory Com- researchers, and will run parallel to the rest of the sessions in mittee – Lance Waller, Amy Xia, Ruthanna Davi, Manisha Desai the scientific program. As in previous years, the regular con- and Joan Buenconsejo; and the Local Arrangments Co-Chairs, tributed and invited posters will be featured Sunday evening, Matthew Guerra and Clara Kim. during the Opening Mixer. Because of its past popularity, we will also continue the ENAR Regional Advisory Board’s (RAB) poster Keynote Lecture: I am thrilled to announce that Dr. Louise Ryan competition. Only posters featured in the Sunday’s contributed will deliver this year’s Presidential Invited Address as another session are eligible for the competition. highlight of the 2017 ENAR Meeting. To learn more about Dr. Ryan and her Invited Address, please see page 13. Educational Program: Curious about a new research area? Want to gain a deeper understanding in your current area of research? Tuesday Night Event: In addition to all the great science, Ever wanted to peek behind the curtain of the NIH review process? educational and networking opportunities planned for the Enjoy lifelong learning simply for the sake of learning? Ever won- meeting, I am equally delighted to announce the debut of the dered what statisticians actually do at Lyft? There is no better way Imposteriors (http://imposteriors.wix.com/imposteriors) for to enhance your understanding of methodology, software, various the ENAR 2017 Tuesday Night Social Event! Why? Why not?! The areas of application or for your own career development than this band features our very own ENAR members and fellow statisti- year’s Education Program. The Education Advisory Committee cians Brad Carlin on keyboards and vocals, Mark Glickman on has assembled an enriching suite of short courses, tutorials bass and vocals, Don Hedeker on guitars and vocals, Jennifer and roundtables featuring a wide range of topics delivered by Hill on percussion and vocals and Michael Jordan on drums. renowned instructors and thought leaders. Formerly associated primarily with Bayesian song parodies, the group has now played a wide variety of dance parties in the US, The short course topics cover a range of areas including risk Mexico, and Europe, and is thrilled to be adding the ENAR social prediction modeling, data science, contemporary regression event to the list! Be sure to stop by on Tuesday night to unwind modeling strategies, dynamic treatment regimes, neuroim- and let loose a bit; this is a show not to be missed! aging and program monitoring and evaluation methods. For a more intimate discussion, consider registering for one of our roundtable luncheons. This year’s roundtable discussions Welcome to the nation's capital will feature distinguished statisticians from academia, govern- and the 2017 ENAR Spring Meeting. ment, and industry. Topics will range from the ever-popular How to Publish without Perishing to The Joy of Study section! Scarlett L. Bellamy, ENAR 2017 President Be sure to take a look and sign up for something interesting! Kathy Hoskins, ENAR Executive Director MARCH 12–15 | Washington Hilton | Washington, DC 5 ENAR 2017 SPRING MEETING ACKNOWLEDGEMENTS ENAR would like to acknowledge the generous support of the 2017 Local Arrangements Committee, chaired by Clara Kim and Matthew Guerra, and our student volunteers. The White House We gratefully acknowledge the invaluable support and generosity of our 2017 Sponsors and Exhibitors: We gratefully acknowledge NIH, and in particular the: SPONSORS National Cancer Institute AbbVie National Heart, Lung, and Blood Institute Boehringer Ingelheim Pharmaceuticals, Inc. National Institute of Environmental Health Sciences Cytel, Inc. National Institute of Allergy and Infectious Diseases Eli Lilly and Company For their generous support of the ENAR Junior Researchers Workshop Janssen Pharmaceutical Companies ENAR Coalition for Development of Junior Scholars of Johnson & Johnson Boston University School of Public Health Rho Drexel University SAS Institute, Inc. Emory University Statistics Collaborative, Inc. ENAR Icahn School of Medicine at Mount Sinai EXHIBITORS The Johns Hopkins University Cambridge University Press The University of Michigan CRC Press, Taylor & Francis Group The University of Minnesota FDA/Center for Tobacco Products The University of North Carolina at Chapel Hill Flatiron Health The University of Pennsylvania The University of Pittsburgh Oxford University Press The University of Rochester, Department of Biostatistics Penfield Search Partners & Computational Biology RStudio School of Medicine and Public Health, University of Wisconsin - Madison SAS Institute, Inc. JMP Division Vanderbilt University School of Medicine, Department of Biostatistics SAS Institute, Inc. R&D EXECUTIVE COMMITTEE | OFFICERS Springer SBM The Lotus Group President, Scarlett Bellamy Past President, Jianwen Cai Weill Cornell Medicine Department President-Elect, Jeffrey Morris of Healthcare Policy & Research Secretary (2017-2018), Bhramar Mukherjee Wiley Treasurer (2016-2017), Sarah Ratcliffe 6 ENAR 2017 SPRING MEETING | Final Program ACKNOWLEDGEMENTS Regional Committee (RECOM) Appointed Members of Regional Advisory Board President (Chair), Scarlett Bellamy (3-year terms) Eight ordinary members (elected to 3-year terms) Chair, Todd Ogden RAB Chair, Todd Ogden 2015–2017 2015–2017 2016–2018 2017–2019 Sean Devlin Susan Halabi Paul Albert Ciprian Crainiceanu
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