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352 Urinary and Reproductive.Pdf Jordan University of Science and Technology Faculty of Medicine Course Title: Urinary and Reproductive system Course Code: M352. Credit Hours: 8 credit hours. Calendar Description: 8 weeks/ Sem 2/ year 3. Teaching Approaches: Integrated System Course. Contact: [email protected] A. Course description This course is a multidisciplinary integrated course deals with the gross morphology, vasculature, lymphatic drainage and innervation of different organs forming urinary and reproductive system. Various functions, normal development and congenital anomalies of this system will be covered. In addition, normal and pathological microscopic appearance of different components of the system will be discussed. Biochemical and genetic aspects, microorganisms that infect the system as well as drugs that affect this system will be conferred. Teaching methods including lectures, practicals, seminars and small group discussions of clinical oriented problems to enhance self directed learning, will be followed. B. Genral Objectives Upon succesful completion of this course students should be able to: 1. Describe the gross morphology of different organs forming the Urinary and Reproductive System. 2. Understand the normal development of the Urinary and Reproductive System and its congenital anomalies. 3. Discuss the vasculature, lymphatic drainage and innervation of different parts of the Urinary and Reproductive System. 4. Understand various functions of the Urinary and Reproductive System. 5. Describe the microscopic appearance of different components of the Urinary and Reproductive System. 6. Discuss the microorganisms that infect the Urinary and Reproductive System. 7. Understand the pathogenesis of various diseases of the Urinary and Reproductive System. 8. List and describe the pharmacology of various drugs acting on the Urinary and Reproductive System. 9. Understand the bases of the inherited diseases. II. Methods of Instruction: - Lectures. - Practical sessions. - Clinically oriented discussions. III. Evaluation and Distribution of Marks: - Written exam at the end of the system * = 40% - Practical exam at the end of the system * = 16%. - Discussion evaluation*= 4% - Final end-course exam at the end of the semester (Written)* = 40%. * Indicates integrated exam format 1 IV. Recommended Text Books and Atlases: Anatomy: - Principles of Human Anatomy. By G.J. Tortora, latest edition. - Clinical Anatomy for Medical Students: By R.S. Snell, latest edition. - Basic Histology, By L. Carlos Junqueira, latest edition. - Before we are born. By K.L. Morre and T.V.N. Persaud, latest edition. - Grant Atlas of Anatomy, latest edition. Physiology: - Textbook of Medical Physiology. By Guyton and Hall, latest edition. Biochemistry: - Harper’s Biochemistry. By Robert K. Murray and Co., latest edition. - Supplementary Departmental Handouts. Pharmacology: - Lippincott’s IIIustrated Reviews: Pharmacology, latest edition. - Supplementary Departmental Handouts. Pathology: - Basic Pathology. By Kumar, Cotran and Robbins, latest edition. - Supplementary Departmental Handouts. Microbiology: - Medical Microbiology. An Introduction to Infectious Diseases. By Sheries, latest edition. Public Health (Community Medicine): - Supplementary Departmental Handouts. 2 C. Learning (specific) objectives of the Urinary & Reproductive system: After studying the material covered in lectures, practical sessions, clinical seminars and case presentations of this course, and after using his/her private self learning time in a productive way, the student is expected to achieve the following specific objectives: Lectures: # Lecture Title Lecture Objectives 1 Introductory case presentation for the 1. Understand the general outline of the urinary system. urinary part of the system 2. Be familiar with the modalities of teaching throughout the course. (Multidisciplinary) 3. Acknowledge the important relation between normal and abnormal structure and function. 4. Appreciate the importance of basic sciences in clinical application. 2 General topographic anatomy of the 1. Overview of the urinary system. urinary system. 2. Kidney: understand its gross appearance, location in the body, (Anatomy) relation to important organs in the abdomen. 3. Describe the shape of the kidney, renal capsule dimentions, surfaces, poles and the perirenal fat pad. 4. Understand the gross appearance of the internal structures: cortex, medulla, calicies and pelvis. 5. Understand the blood supply and how it is distributed, the venous drainage and how it is collected. 6. Discuss the lymphatic drainage and nervous control of the kidney. 3 Gross anatomy of the urinary system, 1. Understand the anatomical structure of the ureter and its location in blood vessels, lymphatic drainage and the body. innervation. 2. Describe how pain is referred from both kidnies and ureters. (Anatomy) 3. Understand the blood supply, venous drainage and lymphatics of the urinary system. 4. Discuss the innervation of different parts of the urinary system, with special attention to the nervous control of urinary bladder. 4 Embryology of the urinary system. 1. Understand the development of the kidney and related organs of (Anatomy) the urinary system. 2. Define the pronephrons, mesonephrons and metanephrons. 3. Understand the major and common congenital abnormalities in the urinary system. 5 Histology of the kidney. 1. Describe the normal microscopic appearance of the different parts (Anatomy) of the kidney including cortex, medulla, juxtaglomerular apparatus and the distribution of the vasculature within the kidney. 2. List the different parts of the nephron with the details of each part. 6 Congenital and cystic diseases of the 1. Define the main congenital diseases of the kidney. kidney. 2. Understand different types, pathogenesis, morphology, and (Pathology) presentation of cystic diseases of the kidney. 7 Glomerular filtration (GF). 1. Review the functions of the nephron. (Physiology) 2. Understand the process of renal blood flow and glomerular filtration. 3. Understand the glomerular membrane, and the dynamics of glomerular filtration. 4. List the factors that affect glomerular filtration rate (GFR). 8 Reabsorption and secretion. 1. Understand the transport and the pathways of reabsorption. (Physiology) 2. Discuss the reabsorption of water and electrolytes. 3. Discuss the reabsorption of glucose, urea, creatinine and protein. 9 Special aspects of renal metabolism. 1. Discuss urea and creatinine metabolism. Role of kidney in acid base balance. 2. Understand the role of kidney in the regulation of hydrogen ions (Biochemistry) and bicarbonate buffer system. 3. Discuss amino acids absorption by the kidney and their disorders. 3 10 Regulation of the GF and renal-blood 1. Understand the autoregulation and tubuloglomerular feedback. flow (RBF). 2. Understand the juxtoglomerular apparatus and its role in renin- (Physiology) angiotensin system. 3. Understand the glomerulotubular balance. 11 Glomerulonephritis. 1. Discuss the pathogenesis of glomerulonephritis. (Pathology) 2. Recognize the basic reactions of glomerulous to injury. 3. List the different renal syndromes associated with renal Pathology. 12 Nephritic syndrome. 1. Discuss the manifestations and mechanism of nephritic syndrome. (Pathology) 2. List the types of glomerulonephritis associated with nephritic syndrome. 3. Discuss the etiology, pathogenesis, morphology and clinical features of the common types of glomerulonephritis leading to nephritic syndrome. 13 Nephrotic syndrome. 1. List the components of nephrotic syndrome. (Pathology) 2. Discuss the pathogenesis of nephrotic syndrome. 3. List the main causes of nephrotic syndrome. 4. Discuss the etiology, morphology, pathogenesis and clinical features of the common types of glomerulonephritis leading to nephrotic syndrome. 14 Glomerular pathology in systemic 1. Discuss the glomerular lesions associated with disease. - Diabetes mellitus. (Pathology) - Systemic lupus erythematosis. - Henoch-shonlein purpura. - Multiple myeloma. - Gout. - Endocarditis. 15 Parameter of renal active transport. 1. Discuss the renal tubular transport maximum (Tm). (Physiology) 2. Define the filtered load and excretion. 3. Understand the glucose and para-aminohippuric acid (PAH) titration curve. 16 Renal clearance. 1. Understand the mechanisms of renal clearance and its applications. (Physiology) 2. Describe the inulin, creatinine and PAH clearance. 17 Renal concentration and dilution of 1. Understand the mechanisms of dilution and concentration urine. - Counter current multipliers. (Physiology) - Counter current exchangers. 2. Discuss the role of urea. 18 Diuretic agents-I. 1. List major types of diuretics and relate them to their sites of action. (Pharmacology) 2. List the major applications, toxicities, and the efficacy of thiazides, loop diuretics and potassium-sparing diuretics. 3. Describe two drugs that reduce potassium loss during diuresis. 19 Diuretic agents-II. 1. Describe a therapy that will reduce calcium excretion in patients (Pharmacology) who have recurrent urinary stones. 2. Discuss the principle of force diuresis. 3. Describe the drugs for reducing urine volume in nephrogenic diabetes insipidus. 20 Gross anatomy and histology of ureter 1. Describe the structure of the urinary bladder and its relations to the urinary bladder and urethra. peritoneum. (Anatomy) 2. Understand the urethra and the difference between males and females. 3. Describe the structure and relations of the male urethra in different regions. 4. Describe the microscopical
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