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Pharnygeal Arch Set - Motor USMLE, Limited Edition > Neuroscience > Neuroscience
CNs 5, 7, 9, 10 - Pharnygeal Arch Set - Motor USMLE, Limited Edition > Neuroscience > Neuroscience PHARYNGEAL ARCH SET, CNS 5, 7, 9, 10 • They are derived from the pharyngeal (aka branchial) arches • They have special motor and autonomic motor functions CRANIAL NERVES EXIT FROM THE BRAINSTEM CN 5, the trigeminal nerve exits the mid/lower pons.* CN 7, the facial nerve exits the pontomedullary junction.* CN 9, the glossopharyngeal nerve exits the lateral medulla.* CN 10, the vagus nerve exits the lateral medulla.* CRANIAL NERVE NUCLEI AT BRAINSTEM LEVELS Midbrain • The motor trigeminal nucleus of CN 5. Nerve Path: • The motor division of the trigeminal nerve passes laterally to enter cerebellopontine angle cistern. Pons • The facial nucleus of CN 7. • The superior salivatory nucleus of CN 7. Nerve Path: • CN 7 sweeps over the abducens nucleus as it exits the brainstem laterally in an internal genu, which generates a small bump in the floor of the fourth ventricle: the facial colliculus • Fibers emanate from the superior salivatory nucleus, as well. Medulla • The dorsal motor nucleus of the vagus, CN 10 • The inferior salivatory nucleus, CN 9 1 / 3 • The nucleus ambiguus, CNs 9 and 10. Nerve Paths: • CNs 9 and 10 exit the medulla laterally through the post-olivary sulcus to enter the cerebellomedullary cistern. THE TRIGEMINAL NERVE, CN 5  • The motor division of the trigeminal nerve innervates the muscles of mastication • It passes ventrolaterally through the cerebellopontine angle cistern and exits through foramen ovale as part of the mandibular division (CN 5[3]). Clinical Correlation - Trigeminal Neuropathy THE FACIAL NERVE, CN 7  • The facial nucleus innervates the muscles of facial expression • It spans from the lower pons to the pontomedullary junction. -
Facial Nerve Disorders Cn7 (1)
FACIAL NERVE DISORDERS CN7 (1) Facial Nerve Disorders Last updated: January 18, 2020 FACIAL PALSY .......................................................................................................................................... 1 ETIOLOGY .............................................................................................................................................. 1 GUIDE TO LESION SITE LOCALIZATION ................................................................................................... 2 CLINICAL GRADING OF SEVERITY .......................................................................................................... 2 House-Brackmann grading scale ........................................................................................... 2 CLINICO-ANATOMICAL SYNDROMES ..................................................................................................... 2 Supranuclear (Central) Palsy ................................................................................................. 2 Nuclear Lesion ...................................................................................................................... 3 Cerebellopontine Angle Syndrome ....................................................................................... 3 Facial Canal Syndrome ......................................................................................................... 3 Stylomastoid Foramen Syndrome ........................................................................................ -
The Clinical Treatment and Outcome of Cerebellopontine Angle
www.nature.com/scientificreports OPEN The clinical treatment and outcome of cerebellopontine angle medulloblastoma: a retrospective study of 15 cases Tao Wu 1,4, Pei-ran Qu3,4, Shun Zhang2, Shi-wei Li1, Jing Zhang1, Bo Wang2, Pinan Liu 1,2, Chun-de Li1,2 & Fu Zhao 1,2 ✉ Medulloblastoma (MB) is the most common malignant pediatric brain tumor arising in the cerebellum or the 4th ventricle. Cerebellopontine angle (CPA) MBs are extremely rare tumors, with few cases previously described. In this study, we sought to describe the clinical characteristics, molecular features and outcomes of CPA MB. We retrospectively reviewed a total of 968 patients who had a histopathological diagnosis of MB at the Beijing Neurosurgical Institute between 2002 and 2016. The demographic characteristics, clinical manifestations and radiological features were retrospectively analyzed. Molecular subgroup was evaluated by the expression profling array or immunohistochemistry. Overall survival (OS) and progression-free survival (PFS) were calculated using Kaplan-Meier analysis. In this study, 15 patients (12 adults and 3 children) with a mean age at diagnosis of 25.1 years (range 4–45 years) were included. CPA MBs represented 1.5% of the total cases of MB (15/968). Two molecular subgroups were identifed in CPA MBs: 5 WNT-MBs (33%) and 10 SHH-MBs (67%). CPA WNT-MBs had the extracerebellar growth with the involvement of brainstem (P = 0.002), whereas CPA SHH-MBs predominantly located within the cerebellar hemispheres (P = 0.004). The 5-year OS and PFS rates for CPA MB were 80.0% ± 10.3% and 66.7% ± 12.2%, respectively. -
DR. Sanaa Alshaarawy
By DR. Sanaa Alshaarawy 1 By the end of the lecture, students will be able to : Distinguish the internal structure of the components of the brain stem in different levels and the specific criteria of each level. 1. Medulla oblongata (closed, mid and open medulla) 2. Pons (caudal, mid “Trigeminal level” and rostral). 3. Mid brain ( superior and inferior colliculi). Describe the Reticular formation (structure, function and pathway) being an important content of the brain stem. 2 1. Traversed by the Central Canal. Motor Decussation*. Spinal Nucleus of Trigeminal (Trigeminal sensory nucleus)* : ➢ It is a larger sensory T.S of Caudal part of M.O. nucleus. ➢ It is the brain stem continuation of the Substantia Gelatinosa of spinal cord 3 The Nucleus Extends : Through the whole length of the brain stem and upper segments of spinal cord. It lies in all levels of M.O, medial to the spinal tract of the trigeminal. It receives pain and temperature from face, forehead. Its tract present in all levels of M.O. is formed of descending fibers that terminate in the trigeminal nucleus. 4 It is Motor Decussation. Formed by pyramidal fibers, (75-90%) cross to the opposite side They descend in the Decuss- = crossing lateral white column of the spinal cord as the lateral corticospinal tract. The uncrossed fibers form the ventral corticospinal tract. 5 Traversed by Central Canal. Larger size Gracile & Cuneate nuclei, concerned with proprioceptive deep sensations of the body. Axons of Gracile & Cuneate nuclei form the internal arcuate fibers; decussating forming Sensory Decussation. Pyramids are prominent ventrally. 6 Formed by the crossed internal arcuate fibers Medial Leminiscus: Composed of the ascending internal arcuate fibers after their crossing. -
Auditory and Vestibular Systems Objective • to Learn the Functional
Auditory and Vestibular Systems Objective • To learn the functional organization of the auditory and vestibular systems • To understand how one can use changes in auditory function following injury to localize the site of a lesion • To begin to learn the vestibular pathways, as a prelude to studying motor pathways controlling balance in a later lab. Ch 7 Key Figs: 7-1; 7-2; 7-4; 7-5 Clinical Case #2 Hearing loss and dizziness; CC4-1 Self evaluation • Be able to identify all structures listed in key terms and describe briefly their principal functions • Use neuroanatomy on the web to test your understanding ************************************************************************************** List of media F-5 Vestibular efferent connections The first order neurons of the vestibular system are bipolar cells whose cell bodies are located in the vestibular ganglion in the internal ear (NTA Fig. 7-3). The distal processes of these cells contact the receptor hair cells located within the ampulae of the semicircular canals and the utricle and saccule. The central processes of the bipolar cells constitute the vestibular portion of the vestibulocochlear (VIIIth cranial) nerve. Most of these primary vestibular afferents enter the ipsilateral brain stem inferior to the inferior cerebellar peduncle to terminate in the vestibular nuclear complex, which is located in the medulla and caudal pons. The vestibular nuclear complex (NTA Figs, 7-2, 7-3), which lies in the floor of the fourth ventricle, contains four nuclei: 1) the superior vestibular nucleus; 2) the inferior vestibular nucleus; 3) the lateral vestibular nucleus; and 4) the medial vestibular nucleus. Vestibular nuclei give rise to secondary fibers that project to the cerebellum, certain motor cranial nerve nuclei, the reticular formation, all spinal levels, and the thalamus. -
Lipoma of the Midbrain
LIPOMA OF THE MIDBRAIN POST-MORTEM FINDING IN A PATIENT WITH BREAST CANCER VERÔNICA MAIA GOUVEA * — MYRIAM DUMAS HAHN ** — LEILA CHIMELLI ** SUMMARY — Intracranial lipomas are rare, usually do not have clinical expression and are located mare frequently in the corpus callosum. Other locations include the spinal cord, midbrain tectum, superior vermis, tuber cinereum, infundibulum and more rarely cerebello pontine angle, hypothalamus, superior medullary velum and insula. We report the case of a lipoma of the left inferior colliculus which was a post-mortem finding in a woman who died of breast cancer. Although there are reports of intracranial lipomas in patients with malignant tumors there is no explanation for the co-existence of the two tumors. The present tumor also includes a segment of a nerve which is not uncommon, but a less common finding was the presence of nests of Schwann cells within it, shown by immunohistochemistry. Lipoma do mesencéfalo: achado de necrópsia, em paciente com câncer da mama. RESUMO — Lipomas intracranianos são raros, em geral sem expressão clínica, localizados mais freqüentemente no corpo caloso. Outras localizações incluem medula espinhal, teto mesencefálico, vermis superior, tuber cinereum, infundibulum e mais raramente o ângulo ponto-cerebelar, hipotálamo, véu medular superior e insula. Relatamos o achado de necrópsia de um lipoma do colículo inferior esquerdo em uma mulher com câncer de mama. Embora haja relatos de lipomas intracranianos em pacientes com tumores malignos não há explicação para a co-existência dos dois tumores. O presente tumor também inclui o segmento de um nervo, o que não é incomum, mas um achado menos comum foi a presença de ninhos de células de Schwann no tumor, mostradas por imuno-histoquímica. -
Anatomy of the Brainstem
Anatomy of the Brainstem Neuroanatomy block-Anatomy-Lecture 5 Editing file Objectives At the end of the lecture, students should be able to: 01 List the components of brain stem. 02 Describe the site of brain stem 03 Describe the relations between components of brain stem & their relations to cerebellum. 04 Describe the external features of both ventral & dorsal surfaces of brain stem Color guide 05 List cranial nerves emerging from brain stem 06 Describe the site of emergence of each cranial nerve ● Only in boys slides in Green ● Only in girls slides in Purple ● important in Red ● Notes in Grey Development of Brain Brain stem ● The brain develops from the cranial part of neural tube. ● The brainstem is the region of the brain that connects the ● The cranial part is divided into 3 parts: cerebrum with the spinal cord. ● Site: It lies on the basilar part of occipital bone (clivus). - Subdivided into: ● Parts from above downwards : 1. Telencephalon: (cavities: 2 lateral ventricles) 1. Midbrain Two cerebral hemispheres. Forebrain 2. Pons 2. Diencephalon: (cavity: 3rd ventricle) 3. Medulla oblongata thalamus, hypothalamus, epithalamus & subthalamus ● Connection with cerebellum: Each part of the brain stem is connected to the Midbrain - (cavity: cerebral aqueduct) cerebellum by cerebellar peduncles (superior, middle & inferior). - (cavity: 4th ventricle) - Subdivided into: Hindbrain 1. Pons 2. Cerebellum 3. Medulla oblongata 3 Sagittal section of Brain 4 Functions of the Brain Stem Pathway of tracts between cerebral cortex & spinal cord (ascending and descending tracts). 1 Site of origin of nuclei of cranial nerves (from 3rd to 12th). 2 Site of emergence of cranial nerves (from 3rd to 12th). -
Brainstem and Its Associated Cranial Nerves
Brainstem and its Associated Cranial Nerves Anatomical and Physiological Review By Sara Alenezy With appreciation to Noura AlTawil’s significant efforts Midbrain (Mesencephalon) External Anatomy of Midbrain 1. Crus Cerebri (Also known as Basis Pedunculi or Cerebral Peduncles): Large column of descending “Upper Motor Neuron” fibers that is responsible for movement coordination, which are: a. Frontopontine fibers b. Corticospinal fibers Ventral Surface c. Corticobulbar fibers d. Temporo-pontine fibers 2. Interpeduncular Fossa: Separates the Crus Cerebri from the middle. 3. Nerve: 3rd Cranial Nerve (Oculomotor) emerges from the Interpeduncular fossa. 1. Superior Colliculus: Involved with visual reflexes. Dorsal Surface 2. Inferior Colliculus: Involved with auditory reflexes. 3. Nerve: 4th Cranial Nerve (Trochlear) emerges caudally to the Inferior Colliculus after decussating in the superior medullary velum. Internal Anatomy of Midbrain 1. Superior Colliculus: Nucleus of grey matter that is associated with the Tectospinal Tract (descending) and the Spinotectal Tract (ascending). a. Tectospinal Pathway: turning the head, neck and eyeballs in response to a visual stimuli.1 Level of b. Spinotectal Pathway: turning the head, neck and eyeballs in response to a cutaneous stimuli.2 Superior 2. Oculomotor Nucleus: Situated in the periaqueductal grey matter. Colliculus 3. Red Nucleus: Red mass3 of grey matter situated centrally in the Tegmentum. Involved in motor control (Rubrospinal Tract). 1. Inferior Colliculus: Nucleus of grey matter that is associated with the Tectospinal Tract (descending) and the Spinotectal Tract (ascending). Tectospinal Pathway: turning the head, neck and eyeballs in response to a auditory stimuli. 2. Trochlear Nucleus: Situated in the periaqueductal grey matter. Level of Inferior 3. -
ON-LINE FIG 1. Selected Images of the Caudal Midbrain (Upper Row
ON-LINE FIG 1. Selected images of the caudal midbrain (upper row) and middle pons (lower row) from 4 of 13 total postmortem brains illustrate excellent anatomic contrast reproducibility across individual datasets. Subtle variations are present. Note differences in the shape of cerebral peduncles (24), decussation of superior cerebellar peduncles (25), and spinothalamic tract (12) in the midbrain of subject D (top right). These can be attributed to individual anatomic variation, some mild distortion of the brain stem during procurement at postmortem examination, and/or differences in the axial imaging plane not easily discernable during its prescription parallel to the anterior/posterior commissure plane. The numbers in parentheses in the on-line legends refer to structures in the On-line Table. AJNR Am J Neuroradiol ●:●●2019 www.ajnr.org E1 ON-LINE FIG 3. Demonstration of the dentatorubrothalamic tract within the superior cerebellar peduncle (asterisk) and rostral brain stem. A, Axial caudal midbrain image angled 10° anterosuperior to posteroinferior relative to the ACPC plane demonstrates the tract traveling the midbrain to reach the decussation (25). B, Coronal oblique image that is perpendicular to the long axis of the hippocam- pus (structure not shown) at the level of the ventral superior cerebel- lar decussation shows a component of the dentatorubrothalamic tract arising from the cerebellar dentate nucleus (63), ascending via the superior cerebellar peduncle to the decussation (25), and then enveloping the contralateral red nucleus (3). C, Parasagittal image shows the relatively long anteroposterior dimension of this tract, which becomes less compact and distinct as it ascends toward the thalamus. ON-LINE FIG 2. -
Pilocytic Astrocytoma of the Cerebellopontine Angle in a Child Presenting with Auditory Neuropathy Spectrum Disorder
Otology & Neurotology 00:00Y00 Ó 2014, Otology & Neurotology, Inc. Imaging Case of the Month Pilocytic Astrocytoma of the Cerebellopontine Angle in a Child Presenting With Auditory Neuropathy Spectrum Disorder *Frederike Schneider, *Martin Kompis, †Christoph Ozdoba, ‡Ju¨rgen Beck, *Marco Caversaccio, and *Pascal Senn *University Department of Otorhinolaryngology, Head and Neck Surgery, ÞUniversity Institute of Diagnostic and Interventional Neuroradiology, and þUniversity Department of Neurosurgery, Inselspital, Bern, Switzerland Auditory neuropathy spectrum disorder (ANSD) is a preserved transient evoked OAEs (TEOAEs), and patho- clinical syndrome with hearing loss characterized by logic BERA findings on the left side indicating unilateral measurable otoacoustic emissions (OAEs) and absent or ANSD (Fig. 1). On the right side, all tests were normal abnormal brain stem evoked response audiometry find- (Fig. 1). ings (BERA) (1,2). Routine magnetic resonance imaging The unenhanced, T2-weighted axial images showed a (MRI) has been advocated in children with ANSD be- large, partially cystic, expansive tumor in the cerebello- cause cochlear, neural, or central abnormalities are ob- pontine angle (CPA) on the left side with displacement of served in up to 64% of affected cases (2). In the two the brain stem and the lower Cranial Nerves VII and VIII largest reported imaging series comprising a combined (Fig. 1). Postgadolinium axial and coronal sequences total of 221 children, developmental malformations, such showed strong enhancement of the CPA lesion (Fig. 2). as cochlear nerve deficiency or hindbrain malformations, A retromastoidal craniotomy with subtotal tumor re- were predominantly observed, suggesting a benign origin moval was performed in the neurosurgery department. of ASND in general. Bilateral ANSD cases are approxi- Total resection was not possible because of unclear bor- mately 4 times more frequently associated with intracra- ders between tumor mass and vital brain stem structures. -
Differential Diagnosis and Surgical Management of Cerebellopontine Angle Cystic Lesions Tobias Alécio Mattei, M.D.1 Carlos R
66 Revisão Differential Diagnosis and Surgical Management of Cerebellopontine Angle Cystic Lesions Tobias Alécio Mattei, M.D.1 Carlos R. Goulart, B.S2 Julia Schemes de Lima, B.S.3 Ricardo Ramina, M.D, PhD.4 SUMÁRIO ABSTRACT A maioria dos tumores de ângulo ponto-cerebelar em adultos Cerebellopontine angle (CPA) tumors in adults are mainly são benignos e extra-axiais. A lesão mais comum do ângulo benign and extra-axial. Although the most common CPA lesion ponto-cerebelar (schwannoma vestibular) é familiar à maioria (vestibular schwannoma) is familiar to most neurosurgeons, dos neurocirurgiões. Entretanto lesões císticas do ângulo cystic lesions of the CPA do pose an important diagnostic ponto-cerebelar merecem uma análise cuidadosa, levando-se challenge demanding a careful consideration of a wide em consideração uma ampla gama de diagnósticos diferenciais, range of differential diagnosis including: epidermoid cysts, dentre os quais: cistos epidermóides, cistos aracnóides, arachnoid cysts, cystic schwannomas, cystic meningiomas neurinomas císticos, meningiomas císticos, bem como outras as well as other rare entities such as vascular and malignant entidades mais raras como lesões vasculares e tumorais tumoral lesions. The authors present a critical review of malignas. Os autores apresentam uma revisão critica da the current literature on cystic CPA lesions, providing an literatura, proporcionando ao leitor uma visão geral sobre os overview about possible differentials as well as guidelines for possíveis diagnósticos diferenciais bem como atuais diretrizes preoperative imaging evaluation of a cystic CPA lesion. para a avaliação imagenológica de lesões císticas no ângulo Keywords: Cerebello-pontine angle, epidermoid cysts, ponto-cerebelar. arachnoid cysts, cystic schwannomas, cystic meningiomas, diferencial diagnosis, surgical management. -
Impaired Cerebro-Cerebellar White Matter Connectivity and Its
www.nature.com/npjschz ARTICLE OPEN Impaired cerebro-cerebellar white matter connectivity and its associations with cognitive function in patients with schizophrenia ✉ Sung Eun Kim1, Sungcheol Jung2, Gyhye Sung1,3, Minji Bang 1 and Sang-Hyuk Lee1 Schizophrenia is a complex brain disorder of unknown etiology. Based on the notion of “cognitive dysmetria,” we aimed to investigate aberrations in structural white matter (WM) connectivity that links the cerebellum to cognitive dysfunction in patients with schizophrenia. A total of 112 participants (65 patients with schizophrenia and 47 healthy controls [HCs]) were enrolled and underwent diffusion tensor imaging. Between-group voxel-wise comparisons of cerebellar WM regions (superior/middle [MCP]/ inferior cerebellar peduncle and pontine crossing fibers) were performed using Tract-Based Spatial Statistics. Cognitive function was assessed using the Trail Making Test Part A/B (TMT-A/B), Wisconsin Card Sorting Test (WCST), and Rey-Kim Memory Test in 46 participants with schizophrenia. WM connectivity, measured as fractional anisotropy (FA), was significantly lower in the MCP in participants with schizophrenia than in HCs. The mean FAs extracted from the significant MCP cluster were inversely correlated with poorer cognitive performance, particularly longer time to complete the TMB-B (r = 0.559, p < 0.001) and more total errors in the WCST (r = 0.442, p = 0.003). Our findings suggest that aberrant cerebro-cerebellar communication due to disrupted WM connectivity may contribute to cognitive impairments, a core characteristic of schizophrenia. Our results may expand our 1234567890():,; understanding of the neurobiology of schizophrenia based on the cerebro-cerebellar interconnectivity of the brain. npj Schizophrenia (2021) 7:38 ; https://doi.org/10.1038/s41537-021-00169-w INTRODUCTION patients with schizophrenia, implying the possible involvement of Schizophrenia is a complex brain disorder of unknown etiology.