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  • Neurogenic Decisions Require a Cell Cycle Independent Function of The
    RESEARCH ARTICLE Neurogenic decisions require a cell cycle independent function of the CDC25B phosphatase Fre´ de´ ric Bonnet1†, Angie Molina1†, Me´ lanie Roussat1, Manon Azais2, Sophie Bel-Vialar1, Jacques Gautrais2, Fabienne Pituello1*, Eric Agius1* 1Centre de Biologie du De´veloppement, Centre de Biologie Inte´grative, Universite´ de Toulouse, CNRS, UPS, Toulouse, France; 2Centre de Recherches sur la Cognition Animale, Centre de Biologie Inte´grative., Universite´ de Toulouse, CNRS, UPS, Toulouse, France Abstract A fundamental issue in developmental biology and in organ homeostasis is understanding the molecular mechanisms governing the balance between stem cell maintenance and differentiation into a specific lineage. Accumulating data suggest that cell cycle dynamics play a major role in the regulation of this balance. Here we show that the G2/M cell cycle regulator CDC25B phosphatase is required in mammals to finely tune neuronal production in the neural tube. We show that in chick neural progenitors, CDC25B activity favors fast nuclei departure from the apical surface in early G1, stimulates neurogenic divisions and promotes neuronal differentiation. We design a mathematical model showing that within a limited period of time, cell cycle length modifications cannot account for changes in the ratio of the mode of division. Using a CDC25B point mutation that cannot interact with CDK, we show that part of CDC25B activity is independent *For correspondence: of its action on the cell cycle. [email protected] (FP); [email protected] (EA) †These authors contributed equally to this work Introduction In multicellular organisms, managing the development, homeostasis and regeneration of tissues Competing interests: The requires the tight control of self-renewal and differentiation of stem/progenitor cells.
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  • Report of the MPSAC Subcommittee for the Review of the Physics
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  • A Bibliometric Analysis of Publications in Ambio in the Last Four Decades
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  • THE OA EFFECT: HOW DOES OPEN ACCESS AFFECT the USAGE of SCHOLARLY BOOKS? White Paper
    springernature.com Illustration inspired by the work of Jean-Claude Bradley Open Research THE OA EFFECT: HOW DOES OPEN ACCESS AFFECT THE USAGE OF SCHOLARLY BOOKS? White paper Open Research: Journals, books, data and tools from: 2 The OA effect: How does open access affect the usage of scholarly books? springernature.com Contents Authors Foreword . 3 Christina Emery, Mithu Lucraft, Executive summary . 4 Agata Morka, Ros Pyne Introduction . 5 November 2017 Part 1: Quantitative findings . 6 Summary . 6 Downloads . 7 Citations and mentions . 11 Part 2: Qualitative findings . 13 Summary . 13 Reasons for publishing open access . 14 Experience of publishing open access . 15 The future of open access . 16 Discussion . 18 Conclusion and recommendations . 20 Acknowledgements . 22 Contacts . 23 About Springer Nature and OA books . 24 Appendices . 26 Appendix 1: Definitions and limitations . 26 Appendix 2: Methodology . 27 Appendix 3: Top 10 downloaded books . 29 Appendix 4: Interviewed authors and funders . 30 Appendix 5: Author questionnaire . 32 Appendix 6: Funder questionnaire . 33 Appendix 7: References . 34 This work is licensed under a Creative Commons Attribution International License (CC BY 4.0) The OA effect: How does open access affect the usage of scholarly books? springernature.com 3 Foreword Springer Nature was created in 2015, but from our earliest days as Springer, Palgrave Macmillan and Nature, we have been publishing monographs and long-form research for some 175 years. The changing environment for book publishing has created both opportunities and challenges for researchers and their funders, for publishers, and for the wider community of readers and educators. As a publisher, we have championed new models of scholarship, introducing ebooks in 2006, and our first open access (OA) book in 2011.
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  • Resume of Kejin Hu
    CURRIULUM VITAE Of Kejin Hu PERSONAL INFORMATION Name: Kejin HU Visa status: USA citizen Language(s): English, Chinese Home city: Vestavia Hills, AL, 35226 RANK/TITLE, Assistant Professor Department: Biochemistry and Molecular Genetics Division: UAB Stem Cell Institute Business Address: SHEL 705, 1825 University Boulevard, Birmingham, AL, 35294 Phone: 205-934-4700 (office); 205-876-8693 (home); 205-703-6688 (cell) Fax: 205-975-3335 MEMBERSHIP: ISSCR (international Society for Stem Cell Research), since 2011 Member of Genetics Society of America (GSA, since 2006) EDUCATIONS June, 1999 to May, 2003, PhD, in marine molecular biology at the Department of Zoology, The University of Hong Kong, Hong Kong, China. July, 1995-October, 1997, MPhil, in fungal biochemistry/microbiology in the Hong Kong Polytechnic University. September, 1981-July, 1985, BSc in botany/agronomy at The Central China (Huazhong) Agricultural University, Wuhan, China. TEACHING EXPERIENCE: Advanced Stem Cell/Regenerative medicine, GBSC 709, Since 2014 SCIENTIFIC ACTIVITIES Ad hoc reviewer for the following journals: 1) Stem Cells; 2) Stem Cells and Development; 3) Stem Cell International; 4) Human Immunology; 5) Molecular Biotechnology; 6) Comparative Biochemistry and Physiology; 7) Journal of Heredity; 8) Scientific Reports; 9) Cellular Reprogramming; 10) Cell and Tissue Research; 11) Science Bulletin; 12) Reproduction, Fertility and Development. 1 Grant Reviewer for 1) Medical Research Council (MRC) of the United Kingdom (remote review, 2015); 2) New York Stem Cell Science (panel meeting from 09/28-09/30, 2016); 3) UAB internal grants SCIENTIFIC/ACADEMIC EXPERIENCE 2011 to present, Assistant Professor, Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL September, 2007 to July, 2011, Research Associate in human iPSC reprogramming and human pluripotent stem cell biology, and their differentiation into blood lineage, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI.
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  • Physics (PHYS) 1
    Physics (PHYS) 1 PHYS 270 | INTRODUCTION TO MECHANICS PHYSICS (PHYS) Units: 3 Repeatability: No Core Attributes: First Yr Integration (LC Only), Science/Tech Inquiry area PHYS 102 | PHYSICS OF MODERN LIFE Prerequisites: MATH 150 with a minimum grade of C- or MATH 151 with a Units: 4 Repeatability: No minimum grade of C- Core Attributes: Quantitative reasoning comp, Science/Tech Inquiry area Corequisites: PHYS 270L Non-Core Attributes: Lab A study of the fundamental principles of Newtonian mechanics, kinematics, An introduction to physics concepts and principles with tangents into related and momentum and energy conservation laws. Harmonic oscillations and technologies and global issues. Special attention is paid to devices and networks wave motion will also be discussed. Three hours of lecture weekly. Concurrent that furnish necessities of modern life. No background in physical science is enrollment in 270L required. required. Lab component involves guided hands-on investigation of physics PHYS 270L | MECHANICS LAB principles and related technologies. Units: 1 Repeatability: No PHYS 105 | PHYSICAL SCIENCES FOR K-8 TEACHERS Core Attributes: Science/Tech Inquiry area Units: 3 Repeatability: No Non-Core Attributes: Lab Core Attributes: Science/Tech Inquiry area Prerequisites: PHYS 270 (Can be taken Concurrently) Non-Core Attributes: Lab A laboratory course introducing the concepts and techniques of experimental A laboratory/lecture/discussion class designed to lead students toward an physics. Meets weekly. understanding of selected topics in chemistry and physics. The course topics are PHYS 271 | INTRODUCTION TO ELECTRICITY AND MAGNETISM selected to satisfy the Physical Science specifications of the Science Content Units: 3 Repeatability: No Standards for California Public Schools (K-12).
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  • SUBMISSION from SPRINGER NATURE Making Plan S Successful
    PLAN S IMPLEMENTATION GUIDANCE: SUBMISSION FROM SPRINGER NATURE Springer Nature welcomes the opportunity to provide feedback to the cOAlition S Implementation Guidance and contribute to the discussion on how the transition to Open Access (OA) can be accelerated. Our submission below focuses mainly on the second question posed in the consultation: Are there other mechanisms or requirements funders should consider to foster full and immediate Open Access of research outputs? Making Plan S successful: a commitment to open access Springer Nature is dedicated to accelerating the adoption of Open Access (OA) publishing and Open Research techniques. As the world’s largest OA publisher we are a committed partner for cOAlition S funders in achieving this goal which is also the primary focus of Plan S. Our recommendations below are therefore presented with the aim of achieving this goal. As a first mover, we know the (multiple) challenges that need to be overcome: funding flows that need to change, a lack of cooperation in funder policies, a lack of global coordination, the need for a cultural change in researcher assessment and metrics in research, academic disciplines that lack OA resources, geographic differences in levels of research output making global “Publish and Read” deals difficult and, critically, an author community that does not yet view publishing OA as a priority. While this uncertainty remains, we need the benefits of OA to be better described and promoted as well as support for the ways that enable us and other publishers to cope with the rapidly increasing demand. We therefore propose cOAlition S adopt the following six recommendations which we believe are necessary to deliver Plan S’s primary goal of accelerating the take-up of OA globally while minimising costs to funders and other stakeholders: 1.
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  • Autophagy in the Endocrine Glands
    A WECKMAN and others Autophagy in the endocrine 52:2 R151–R163 Review glands Autophagy in the endocrine glands Andrea Weckman, Antonio Di Ieva, Fabio Rotondo1, Luis V Syro2, Leon D Ortiz3, Kalman Kovacs1 and Michael D Cusimano Division of Neurosurgery, Department of Surgery, St Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada Correspondence 1Division of Pathology, Department of Laboratory Medicine, St Michael’s Hospital, University of Toronto, Toronto, should be addressed Ontario, Canada to A Di Ieva 2Department of Neurosurgery, Hospital Pablo Tobon Uribe and Clinica Medellin, Medellin, Colombia Email 3Division of Neurooncology, Instituto de Cancerologia, Clinic Las Americas, Medellin, Colombia [email protected] Abstract Autophagy is an important cellular process involving the degradation of intracellular Key Words components. Its regulation is complex and while there are many methods available, there is " autophagy currently no single effective way of detecting and monitoring autophagy. It has several " endocrine glands cellular functions that are conserved throughout the body, as well as a variety of different " crinophagy physiological roles depending on the context of its occurrence in the body. Autophagy is also " endocrine diseases involved in the pathology of a wide range of diseases. Within the endocrine system, autophagy has both its traditional conserved functions and specific functions. In the endocrine glands, autophagy plays a critical role in controlling intracellular hormone levels. In peptide-secreting cells of glands such as the pituitary gland, crinophagy, a specific form of autophagy, targets the secretory granules to control the levels of stored hormone. In steroid-secreting cells of glands such as the testes and adrenal gland, autophagy targets the steroid-producing organelles.
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  • Strategic Plan for a 5 - 10 Year Time Horizon Department of Physics and Astronomy
    Preliminary Departmental Strategy Report Strategic plan for a 5 - 10 year time horizon Department of Physics and Astronomy DRAFT Executive Summary The next decade will be exciting and productive for the Department of Physics and Astronomy. Existing programs are all remarkably strong and vital, and the Department is poised for a powerful phase of expansion and progress, thanks in large part to the last two decades of faculty recruitments, research initiatives and bridge building with the rest of the University. Even a modest increase in faculty size is assured to have dramatic impact on our scientific productivity and national ranking. Indeed, we believe that an increase of our national rank into the top twenty in the Nation is a realistic goal. Our students, undergraduate and graduate alike, are among the best in the College and our education programs are strong, and will continue to improve. There is much room for improvement in our home building, Bausch and Lomb Hall, which is among the shabbiest of all buildings on the otherwise beautiful Eastman quad. Its poor physical condition belies the world-class research that goes on within; a significant upgrade is not only required for the Department to maintain its high standards, but will also have a potentially huge payoff in sponsored research. An interdisciplinary initiative in nanoscience, and in biophysics an ongoing faculty search, exemplify our broad, cross-departmental identification of the strategic frontiers of physics. Initiated before the recent request for the present report, a departmental strategic planning cycle is well underway and will produce a new faculty recruitment strategic plan in early 2006.
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  • SPRINGER NATURE Products, Services & Solutions 2 Springer Nature Products, Services & Solutions Springernature.Com
    springernature.com Illustration inspired by the work of Marie Curie SPRINGER NATURE Products, Services & Solutions 2 Springer Nature Products, Services & Solutions springernature.com About Springer Nature Springer Nature advances discovery by publishing robust and insightful research, supporting the development of new areas of knowledge, making ideas and information accessible around the world, and leading the way on open access. Our journals, eBooks, databases and solutions make sure that researchers, students, teachers and professionals have access to important research. Springer Established in 1842, Springer is a leading global scientific, technical, medical, humanities and social sciences publisher. Providing researchers with quality content via innovattive products and services, Springer has one of the most significant science eBooks and archives collections, as well as a comprehensive range of hybrid and open access journals. Nature Research Publishing some of the most significant discoveries since 1869. Nature Research publishes the world’s leading weekly science journal, Nature, in addition to Nature- branded research and review subscription journals. The portfolio also includes Nature Communications, the leading open access journal across all sciences, plus a variety of Nature Partner Journals, developed with institutions and societies. Academic journals on nature.com Prestigious titles in the clinical, life and physical sciences for communities and established medical and scientific societies, many of which are published in partnership a society. Adis A leading international publisher of drug-focused content and solutions. Adis supports work in the pharmaceutical and biotech industry, medical research, practice and teaching, drug regulation and reimbursement as well as related finance and consulting markets. Apress A technical publisher of high-quality, practical content including over 3000 titles for IT professionals, software developers, programmers and business leaders around the world.
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  • The Integration of Human and Physical Geography Revisited
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