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CURRIULUM VITAE Of Kejin Hu PERSONAL INFORMATION Name: Kejin HU Visa status: USA citizen Language(s): English, Chinese Home city: Vestavia Hills, AL, 35226 RANK/TITLE, Assistant Professor Department: Biochemistry and Molecular Genetics Division: UAB Stem Cell Institute Business Address: SHEL 705, 1825 University Boulevard, Birmingham, AL, 35294 Phone: 205-934-4700 (office); 205-876-8693 (home); 205-703-6688 (cell) Fax: 205-975-3335 MEMBERSHIP: ISSCR (international Society for Stem Cell Research), since 2011 Member of Genetics Society of America (GSA, since 2006) EDUCATIONS June, 1999 to May, 2003, PhD, in marine molecular biology at the Department of Zoology, The University of Hong Kong, Hong Kong, China. July, 1995-October, 1997, MPhil, in fungal biochemistry/microbiology in the Hong Kong Polytechnic University. September, 1981-July, 1985, BSc in botany/agronomy at The Central China (Huazhong) Agricultural University, Wuhan, China. TEACHING EXPERIENCE: Advanced Stem Cell/Regenerative medicine, GBSC 709, Since 2014 SCIENTIFIC ACTIVITIES Ad hoc reviewer for the following journals: 1) Stem Cells; 2) Stem Cells and Development; 3) Stem Cell International; 4) Human Immunology; 5) Molecular Biotechnology; 6) Comparative Biochemistry and Physiology; 7) Journal of Heredity; 8) Scientific Reports; 9) Cellular Reprogramming; 10) Cell and Tissue Research; 11) Science Bulletin; 12) Reproduction, Fertility and Development. 1 Grant Reviewer for 1) Medical Research Council (MRC) of the United Kingdom (remote review, 2015); 2) New York Stem Cell Science (panel meeting from 09/28-09/30, 2016); 3) UAB internal grants SCIENTIFIC/ACADEMIC EXPERIENCE 2011 to present, Assistant Professor, Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL September, 2007 to July, 2011, Research Associate in human iPSC reprogramming and human pluripotent stem cell biology, and their differentiation into blood lineage, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI. November, 2006 to September 2007, research associate in molecular pharmacology (drug metabolism in bone marrow) at the Pharmacology Department, University of Wisconsin (Madison), Wisconsin, USA. June, 2004 to October, 2006, Postdoctoral associate in yeast genetics and molecular biology (studying TOR signaling pathway), at Pharmacology Department of University of Pittsburgh, Pittsburgh, PA, USA. July, 2003 to May, 2004, Postdoctoral associate in developmental biology (muscle development) of c. elegans, at Cornell University, NY, USA. March, 1998- September 1998, teaching assistant at Zoology department, Hong Kong University. December, 1993-July, 1995, Lecturer at Hubei Academy of Agricultural Sciences, Wuhan, China. July, 1985-December, 1993, Assistant lecturer at Hubei Academy of Agricultural Sciences. Book chapters 1. Kejin Hu, Igor Slukvin, (2013) Pluripotent stem cells induction from umbilical cord blood. Encyclopedia of Molecular Cell Biology and Molecular Medicine, Wiley-Blackwell. 2. Kejin Hu, Igor Slukvin, (2013) Kejin Hu, Igor Slukvin, 2013, Generation of transgene-free iPSC lines form Human normal and Neoplastic Blood cells using episomal vectors. Methods in Molecular Biology, Vol. 997, Chapter 13, pp 163-176. 3. Kejin Hu. 2008. Homologous recombination and innocuous intron elimination. pp323-334. Chapter 14, In Genetic Recombination Research Progress, edited by Jacob H. Schulz. Journal Papers (*, corresponding author) 1. Z Shao, C Yao, A Khodadadi-Jamayran, W Xu, T Townes, Michael Crowley, Kejin Hu* (2016) Reprogramming by de-bookmarking somatic transcriptional program through targeting of the BET bromodomains. Cell Reports, 16:3138-3145. 2 2. Z Shao, R Zhang, A Khodadadi-Jamayran, B Chen, MR Crowley, MA Festok, DK Crossman, T Townes, Kejin Hu* (2016) The Acetyllysine Reader BRD3R Promotes Human Nuclear Reprogramming and Regulates Mitosis. Nature Communications. 7:10869. 3. L Kang, C Yao, A Khodadadi-Jamayran, W Xu, R Zhang, N Banerjee, C Chang, L Chow, T Townes, Kejin Hu* (2016) The universal 3D3 antibody of human PODXL is pluripotent cytotoxic, and identifies a residual population after extended differentiation of pluripotent stem cells. Stem Cells Dev. 25(7):556-568. 4. Kejin Hu, S Guo, G Yan, W Yuan, Y Zheng, and Y Jiang*, (2016) Ubiquitin regulates TORC1 in yeast Saccharomyces cerevisiae, Molecular Microbiology 100(2):303-314. DOI: 10.1111/mmi.13319. 5. K. Suknuntha, Y. Ishii, L. Tao, Kejin HU, BE McIntosh, D. Yang, s. Swanson, R. Stewart, J Wang, J. Thomson, II Slukvin (2015) Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells. Stem Cell Research. 15(3), 678-693. 6. Kejin Hu* (2014) All roads lead to induced pluripotent stem cells: the technologies of iPSC generation. Stem Cells and Development, 23(12) 1285-1300. PMCID, PMC4046204 7. Kejin Hu* (2014) Vectorology and factor delivery system in induced pluripotent stem cell reprogramming. Stem Cells and Development, 23(12): 1301-1315. PMCID, PMC4046209 8. Kejin Hu, Junying Y, James Thomson, Igor Slukvin (2011) Efficient reprogramming of mononuclear cells from archived normal and neoplastic human bone marrow and cord blood with non-integrating episomal constructs. BLOOD. Vol 117 (14), e109-e119. doi: 10.1182/blood-2010-07-298331. 9. Junying Yu, Kejin Hu, Kim Smuga-Otto, Shulan Tian, Ron Stewart, Igor I Slukvin, James A Thomson, (2009) Human induced pluripotent stem cells free of vector and transgene sequences. Science, Vol. 324, 797-801. PMCID: PMC2758053. 10. Nirav M. Amin, Kejin Hu, David Pruyne, Dino Terzic, Anthony Bretscher and Jun Liu. (2007) A Zn-finger/FH2-domain containing protein, FOZI-1, acts redundantly with CeMyoD to specify striated body wall muscle fates in the Caenorhabditis elegans postembryonic mesoderm. Development, 134(1), 19-29. 11. Kejin Hu*, 2006. Intron exclusion and the mystery of intron loss. FEBS Letters, 580(27), 6361-6365. 12. Kejin Hu* and Pak Chow Leung (2007) Food digestion by cathepsin L and the digestion-related cell differentiation in shrimp hepatopancreas. Comparative Biochemistry and Physiology Part B, 146, 69-80. 13. Kejin Hu* and Pak Chow Leung (2006) Complete, precise and innocuous loss of multiple introns in the currently intronless, active cathepsin L-like genes, and inference from this event. Molecular Phylogenetics and Evolution, 38, 685-696. 14. Ke-jin Hu, Pak-Chow Leung (2004) Shrimp cathepsin L encoded by an intronless gene has predominant expression in hepatopancreas, and occurs in the nucleus of oocyte. Comparative Biochemistry and Physiology, Part B, 137(1), 21-33. 3 15. Kejin Hu*, Kwok-Wing Yeung*, Jinlian Hu, Kwok-ping Ho (2004) Screening of fungi for chitosan producers, and copper adsorption capacity of fungal chitosan and chitosanaceous materials. Carbohydrate Polymers, 58 (1): 45-52. (I am one of the two correspondence authors). 16. KeJin Hu, Kwok-Wing Yeung, Kwok-Ping Ho, and Jin-lian Hu (1999) Rapid extraction of high-quality chitosan from mycelia of Absidia glauca, Journal of Food Biochemistry, 23, 187-196. 17. Qiang Zhou and Kejin Hu (1999) Photoperiod-sensitive genic male-sterile facultative apomixis gene may be used for fixation of heterosis of hybrid rice. Hubei Agricultural Science. 1999(3): 14-15. 18. Kejin Hu* (1995) Mathematical Modeling of the cultivation of Late Keng rice in Hubei, Journal of Central China Agricultural University, Sup. Sum 20, 37-41. 19. Kejin Hu* (1990) Applying LP to planting scheme in Qifang Township. System Sciences and Comprehensive Studies in Agricultures, 1990 (3), 31-34. 20. Shizhao Li, Kejin Hu and Depei Wang (1988) Preliminary studies on the effect of Chinese medical herbs on the shelf life of mung bean cake. Hubei Agricultural Sciences, 1988(6): 41-43. Conference presentations/posters 1. Kran Suknuntha, Yuki Ishii, Kejin Hu, James Thomson, Jean Wang, Slukvin, Igor (June 12-15, 2013) An induced pluripotent stem cell-based platform for in vitro study of chronic myeloid leukemia stem cell development and drug resistance, ISSCR annual 11th meeting. Boston, Massachusetts, USA. 2. Jeffrey Huo, Tea Soon Park, Kurinji Pandiyan , C.C. Talbot, Karan Verma, Ludovic Zimmerlin, Ann Peters, Kejin Hu, Igor Slukvin, Renee Reijo-Pera, Stephen Baylin, & Elias Zambidis (June 12-15, 2013) Rapid erasure of donor-specific epigenetic memory in blood-derived episomal hipsc augments hematopoietic potency, ISSCR annual 11th meeting. Boston, Massachusetts, USA. 3. Tea Soon Park, Ludovic Zimmerlin, Ann Peters, Karan Verma, Jeffrey S. Huo, C. Conover Talbot Jr., Kejin Hu, Igor Slukvin, Renee Reijo-Pera, and Elias T. Zambidis. June 12-15, 2013, Reprogramming of stromal-primed human myeloid progenitors generates hipsc with high fidelity states of pluripotency and augmented multilineage differentiation capacities, ISSCR annual 11th meeting. Boston, Massachusetts, USA. 4. Kejin Hu, Junying Y, James Thomson, Igor Slukvin, Efficient reprogramming of mononuclear cells from archived human bone marrow and cord blood with non-integrating episomal constructs. ISSCR 8th annual meeting, San Francisco, CA, June 16-19, 2010. 5. Kejin Hu and Yu Jiang (July, 2006) Regulation of TOR signaling by ubiquitin. 2006 Yeast Genetics and Molecular Biology Meeting. Princeton University, Princeton, New Jersey, July 25-30, 2006. 6. Nirav Amin, Kejin Hu, David Pruyne, Dino Terzic, Anthony Bretscher, Jun Liu. (2006) 4 Fozi-1 encodes a novel protein required for proper cell fate specification in the post-embryonic mesoderm. Development and Evolution
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