Metabolic reactions containing cDEGs in the genome-based mouse metabolic network Compart Reaction ID Reaction Name Reaction Subsystem Genes Folds ment Bicarbonate transport Transport, 2HCO3_NAt na1_e + 2.0 hco3_e <-> 2.0 hco3_c + na1_c cytosol Slc4a4 0.55556 (Na/HCO3 1:2 cotransport) Extracellular Aldehyde dehydrogenase 3 4 34dhpac_c + h2o_c + nad_c <-> nadh_c + 2.0 Tyrosine 34DHALDD dihydroxyphenylacetaldehyde cytosol Aldh3a1 14.95 h_c + 34dhpha_c metabolism NAD 34DHPLACOX_NA 34DHPLACOX LPAREN h2o_c + 34dhpac_c + nadp_c <-> nadph_c + Tyrosine cytosol Aldh3a1 14.95 DP NADP RPAREN 2.0 h_c + 34dhpha_c metabolism 3,4- 34DHXMANDACO h2o_c + 34dhmald_c + nad_c <-> Tyrosine Dihydroxymandelaldehyde:NA cytosol Aldh3a1 14.95 X 34dhoxmand_c + nadh_c + 2.0 h_c metabolism D+ oxidoreductase Bicarbonate transport Transport, 3HCO3_NAt na1_e + 3.0 hco3_e <-> 3.0 hco3_c + na1_c cytosol Slc4a4 0.55556 (Na/HCO3 1:3 cotransport) Extracellular 3-Methoxy-4- 3mox4hpac_c + nad_c + h2o_c <-> Tyrosine 3M4HDXPAC hydroxyphenylacetaldehyde:NA cytosol Aldh3a1 14.95 homoval_c + nadh_c + 2.0 h_c metabolism D+ oxidoreductase 3-Methoxy-4- 3MOX4HOXPGALD h2o_c + nad_c + 3m4hpga_c <-> Tyrosine hydroxyphenylglycolaldehyde: cytosol Aldh3a1 14.95 OX 3mox4hoxm_c + nadh_c + 2.0 h_c metabolism NAD+ oxidoreductase 3-Methoxy-4- 3MOX4HOXPGALD h2o_c + 3m4hpga_c + nadp_c <-> nadph_c + Tyrosine hydroxyphenylglycolaldehyde: cytosol Aldh3a1 14.95 OX_NADP 3mox4hoxm_c + 2.0 h_c metabolism NADP+ oxidoreductase 4HOXPACDOX_NA 4HOXPACDOX LPAREN h2o_c + 4hoxpacd_c + nadp_c <-> 4hphac_c Tyrosine cytosol Aldh3a1 14.95 DP NADP RPAREN + nadph_c + 2.0 h_c metabolism 5- h2o_c + 5hoxindact_c + nad_c <-> Tryptophan 5HOXINDACTOX Hydroxyindoleacetaldehyde:NA cytosol Aldh9a1 0.52356 5hoxindoa_c + nadh_c + 2.0 h_c metabolism D+ oxidoreductase Aminobutyraldehyde 4abutn_c + h2o_c + nad_c <-> 4abut_c + 2.0 beta-Alanine ABUTD cytosol Aldh9a1 0.52356 dehydrogenase h_c + nadh_c metabolism ADNCYC Adenylate cyclase atp_c <-> camp_c + ppi_c Nucleotides cytosol Adcy7 0.52083 Transport, ALAt4 Alanine-Sodium symporter ala__L_e + na1_e <-> ala__L_c + na1_c cytosol Slc38a4 0.52356 Extracellular Aldehyde dehydrogenase pacald_c + nadp_c + h2o_c <-> nadph_c + Phenylalanine ALDD19x_P cytosol Aldh3a1 14.95 (phenylacetaldehyde, NADP) pac_c + 2.0 h_c metabolism Aldehyde dehydrogenase h2o_c + nad_c + pacald_c <-> 2.0 h_c + Phenylalanine ALDD19xr cytosol Aldh3a1 14.95 (phenylacetaldehyde, NAD) nadh_c + pac_c metabolism Aldehyde dehydrogenase nad_c + h2o_c + id3acald_c <-> 2.0 h_c + Tryptophan ALDD20x cytosol Aldh9a1 0.52356 (indole-3-acetaldehyde, NAD) nadh_c + ind3ac_c metabolism Aldehyde dehydrogenase acald_c + h2o_c + nad_c <-> ac_c + 2.0 h_c + Glycolysis/Glucon Aldh3a1; ALDD2x cytosol 14.95;0.52356 (acetaldehyde, NAD) nadh_c eogenesis Aldh9a1 Aldehyde dehydrogenase acald_c + h2o_c + nadp_c <-> ac_c + 2.0 h_c Glycolysis/Glucon Aldh3a1; ALDD2y cytosol 14.95;0.52356 (acetaldehyde, NADP) + nadph_c eogenesis Aldh9a1 Transport, ARGt5r ARGtiDF arg__L_e <-> arg__L_c cytosol Slc38a4 0.52356 Extracellular L-asparagine transport in via Transport, ASNt4 na1_e + asn__L_e <-> asn__L_c + na1_c cytosol Slc38a4 0.52356 sodium symport Extracellular Beta-Aminopropion aldehyde nad_c + h2o_c + bamppald_c <-> 2.0 h_c + beta-Alanine BAMPPALDOX cytosol Aldh9a1 0.52356 NAD+ oxidoreductase nadh_c + ala_B_c metabolism Glycine, Serine, Betaine-aldehyde betald_c + h2o_c + nad_c <-> glyb_c + 2.0 BETALDHx and Threonine cytosol Aldh9a1 0.52356 dehydrogenase h_c + nadh_c Metabolism Cys-Gly transport in via proton Transport, CGLYt3_2 2.0 h_e + cgly_e <-> cgly_c + 2.0 h_c cytosol Slc15a2 5.26 symport Extracellular Dihydropyrimidinase (5,6- Pyrimidine DHPM1 h2o_c + 56dura_c <-> cala_c + h_c cytosol Dpysl3 0.40984 dihydrouracil) Catabolism Transport, DOPAtu Dopamine uniport dopa_e <-> dopa_c cytosol Slc22a3 0.17331 Extracellular paps_c + estrone_c <-> pap_c + h_c + Steroid ESTSULT Estrogen sulfotransferase cytosol Sult1a1 1.62 estrones_c Metabolism atp_c + coa_c + ptdca_c <-> ppi_c + amp_c + Fatty acid FACOAL150 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ptdcacoa_c activation Fatty acid CoA ligase atp_c + coa_c + hdca_c <-> amp_c + Fatty acid FACOAL160 cytosol Acsl1 0.55249 hexadecanoate pmtcoa_c + ppi_c activation Fatty acid CoA ligase atp_c + coa_c + hdcea_c <-> amp_c + Fatty acid FACOAL161 cytosol Acsl1 0.55249 hexadecenoate hdcoa_c + ppi_c activation coa_c + hpdca_c + atp_c <-> hpdcacoa_c + Fatty acid FACOAL170 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation Fatty acid CoA ligase atp_c + coa_c + ocdca_c <-> amp_c + ppi_c + Fatty acid FACOAL180 cytosol Acsl1 0.55249 octadecanoate stcoa_c activation Fatty acid CoA ligase atp_c + coa_c + ocdcea_c <-> amp_c + Fatty acid FACOAL181 cytosol Acsl1 0.55249 octadecenoate odecoa_c + ppi_c activation coa_c + vacc_c + atp_c <-> vacccoa_c + Fatty acid FACOAL1812 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation atp_c + coa_c + elaid_c <-> od2coa_c + ppi_c Fatty acid FACOAL1813 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 + amp_c activation Linoleic acid:CoA ligase (AMP- atp_c + coa_c + lnlc_c <-> lnlccoa_c + ppi_c Fatty acid FACOAL1821 cytosol Acsl1 0.55249 forming) + amp_c activation lneldc_c + atp_c + coa_c <-> lneldccoa_c + Fatty acid FACOAL1822 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation Gamma-Linolenic acid:CoA atp_c + coa_c + lnlncg_c <-> ppi_c + Fatty acid FACOAL1831 cytosol Acsl1 0.55249 ligase (AMP-forming) lnlncgcoa_c + amp_c activation Alpha-Linolenic acid:CoA coa_c + lnlnca_c + atp_c <-> lnlncacoa_c + Fatty acid FACOAL1832 cytosol Acsl1 0.55249 ligase (AMP-forming) ppi_c + amp_c activation strdnc_c + atp_c + coa_c <-> strdnccoa_c + Fatty acid FACOAL184 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation atp_c + arach_c + coa_c <-> amp_c + Fatty acid FACOAL200 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 arachcoa_c + ppi_c activation atp_c + coa_c + dlnlcg_c <-> ppi_c + Fatty acid FACOAL203 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 dlnlcgcoa_c + amp_c activation coa_c + arachd_c + atp_c <-> arachdcoa_c + Fatty acid FACOAL204 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation coa_c + arachd_c + atp_c <-> arachdcoa_c + Fatty acid FACOAL204 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation eicostet_c + atp_c + coa_c <-> eicostetcoa_c Fatty acid FACOAL2042 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 + ppi_c + amp_c activation coa_c + tmndnc_c + atp_c <-> tmndnccoa_c + Fatty acid FACOAL205 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation coa_c + adrn_c + atp_c <-> adrncoa_c + Fatty acid FACOAL224 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation atp_c + coa_c + dcsptn1_c <-> dcsptn1coa_c Fatty acid FACOAL2251 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 + ppi_c + amp_c activation clpnd_c + coa_c + atp_c <-> clpndcoa_c + Fatty acid FACOAL2252 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation coa_c + atp_c + crvnc_c <-> c226coa_c + Fatty acid FACOAL226 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 amp_c + ppi_c activation atp_c + coa_c + lgnc_c <-> ppi_c + amp_c + Fatty acid FACOAL240 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 lgnccoa_c activation nrvnc_c + atp_c + coa_c <-> nrvnccoa_c + Fatty acid FACOAL241 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation atp_c + coa_c + tettet6_c <-> tettet6coa_c + Fatty acid FACOAL244_1 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation atp_c + coa_c + tetpent6_c <-> ppi_c + Fatty acid FACOAL245_1 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 amp_c + tetpent6coa_c activation tetpent3_c + atp_c + coa_c <-> tetpent3coa_c Fatty acid FACOAL245_2 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 + ppi_c + amp_c activation atp_c + coa_c + tethex3_c <-> tethex3coa_c + Fatty acid FACOAL246_1 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation Fatty-acid--CoA ligase (n- atp_c + coa_c + hexc_c <-> hexccoa_c + Fatty acid FACOAL260 cytosol Acsl1 0.55249 C26:0) ppi_c + amp_c activation Glycerol-3-phosphate Glycolysis/Glucon G3PD2m dehydrogenase (FAD), fad_m + glyc3p_c <-> dhap_c + fadh2_m cytosol Gpd2 1.44 eogenesis mitochondrial Glyoxylate and gcald_c + h2o_c + nad_c <-> glyclt_c + 2.0 Aldh3a1; GCALDD Glycolaldehyde dehydrogenase Dicarboxylate cytosol 14.95;0.52356 h_c + nadh_c Aldh9a1 Metabolism Starch and Tyr_ggn_c + 8.0 udpg_c <-> 8.0 udp_c + GGNG Glycogenin self-glucosylation Sucrose cytosol Gyg 1.55 ggn_c + 8.0 h_c Metabolism Ascorbate and D-Glucuronolactone:NAD+ 2.0 h2o_c + glac_c + nad_c <-> nadh_c + 3.0 Aldh3a1; GLACO Aldarate cytosol 14.95;0.52356 oxidoreductase h_c + glcr_c Aldh9a1 Metabolism Starch and Glycogen synthase (ggn -> ggn_c + 3.0 udpg_c <-> 3.0 udp_c + 3.0 h_c + GLGNS1 Sucrose cytosol Gyg 1.55 glygn1) glygn1_c Metabolism atp_c + glu__L_c + nh4_c <-> adp_c + Glutamate GLNS Glutamine synthetase cytosol Glul 1.82 gln__L_c + h_c + pi_c metabolism L-glutamine reversible transport Transport, GLNt4 na1_e + gln__L_e <-> gln__L_c + na1_c cytosol Slc38a4 0.52356 via sodium symport Extracellular Urea cycle/amino GLYAMDTRc Glycine amidinotransferase (c) gly_c + arg__L_c <-> orn_c + gudac_c cytosol Gatm 0.60976 group metabolism Glycine transport via sodium Transport, GLYt4 na1_e + gly_e <-> gly_c + na1_c cytosol Slc38a4 0.52356 symport Extracellular Glycine, Serine, GNMT Glycine N-methyltransferase amet_c + gly_c <-> sarcs_c + h_c + ahcys_c and Threonine cytosol Gnmt 2.87 Metabolism 2.0 gthrd_e + h2o2_e <-> gthox_e + 2.0 Glutathione GTHPe Glutathione peroxidase cytosol Gpx3 1.78 h2o_e Metabolism Transport, HISTAtu Histamine uniport hista_e <-> hista_c cytosol Slc22a3 0.17331 Extracellular L-histidine transport via Transport, HIStiDF diffusion (extracellular to his__L_e <-> his__L_c cytosol Slc38a4 0.52356 Extracellular cytosol) Testicular 17-beta- nadph_c + h_c + estrone_c <-> nadp_c + Steroid HSD17B1 cytosol H2-Ke6 1.55 hydroxysteroid dehydrogenase estradiol_c Metabolism Imidazole acetaldeyde h2o_c + im4act_c + nad_c <-> 2.0 h_c + Histidine IMACTD cytosol Aldh9a1 0.52356 dehydrogenase im4ac_c + nadh_c Metabolism Transport, KCC2t K+-Cl- cotransporter (NH4+) cl_e + nh4_e <-> cl_c + nh4_c cytosol Slc12a4 1.49 Extracellular Transport, KCCt K+-Cl- cotransport cl_e + k_e <-> cl_c + k_c cytosol Slc12a4 1.49 Extracellular h2o_c + lald__L_c + nad_c <-> 2.0 h_c + Pyruvate Aldh3a1; LCADi Lactaldehyde dehydrogenase cytosol 14.95;0.52356 lac__L_c + nadh_c Metabolism Aldh9a1 lald__D_c + nad_c + h2o_c <-> nadh_c + Pyruvate Aldh3a1; LCADi_D Lactaldehyde dehydrogenase cytosol 14.95;0.52356 lac__D_c + 2.0 h_c Metabolism Aldh9a1 L-leucine transport in via Transport, LEUt4 na1_e + leu__L_e <-> leu__L_c + na1_c cytosol Slc38a4 0.52356 sodium symport Extracellular Transport, LYSt5r LYStiDF lys__L_e <-> lys__L_c cytosol Slc38a4 0.52356 Extracellular 3-Methylimidazole h2o_c + nad_c + 3mldz_c <-> 2.0 h_c + Histidine MACOXO acetaldehyde:NAD+ cytosol Aldh3a1 14.95 nadh_c + 3mlda_c Metabolism oxidoreductase 3-mercaptopyruvate cyan_c + mercppyr_c <-> h_c + pyr_c + Cysteine MCPST cytosol Mpst 1.57 sulfurtransferase tcynt_c Metabolism Inositol Phosphate MI1PP Myo-inositol 1-phosphatase h2o_c + mi1p__D_c <-> inost_c + pi_c cytosol Impa2 0.43103 Metabolism 1D-myo-Inositol 3-phosphate Inositol Phosphate MI3PP mi3p__D_c + h2o_c <-> inost_c + pi_c cytosol Impa2 0.43103 phosphohydrolase Metabolism 1D-myo-Inositol 4-phosphate Inositol Phosphate MI4PP mi4p__D_c + h2o_c <-> inost_c + pi_c cytosol Impa2 0.43103 phosphohydrolase Metabolism Arginine and N4 AcetylaminobutanalNAD h2o_c + n4abutn_c + nad_c <-> 4aabutn_c + NABTNO Proline cytosol Aldh9a1 0.52356 oxidoreductase 2.0 h_c + nadh_c Metabolism Transport, NRPPHRtu Norepinephrine uniport nrpphr_e <-> nrpphr_c cytosol Slc22a3 0.17331 Extracellular Pyrimidine NTD2 5'-nucleotidase (UMP) h2o_c + ump_c <-> pi_c + uri_c cytosol Nt5c3 0.59524 Catabolism Pyrimidine NTD4 5'-nucleotidase (CMP) cmp_c + h2o_c <-> cytd_c + pi_c cytosol Nt5c3 0.59524 Catabolism Urea cycle/amino ORNDC Ornithine Decarboxylase h_c + orn_c <-> co2_c + ptrc_c cytosol Odc1 0.5 group metabolism nadph_c + debrisoquine_c + o2_c + h_c <-> P4502D6 Cytochrome P450 2D6 CYP Metabolism cytosol Cyp2d22 1.72 h2o_c + 4hdebrisoquine_c + nadp_c 3',5'-cyclic-nucleotide PDE1 camp_c + h2o_c <-> amp_c + h_c Nucleotides cytosol Pde10a 0.36765 phosphodiesterase 3',5'-cyclic-nucleotide PDE4 35cgmp_c + h2o_c <-> gmp_c + h_c Nucleotides cytosol Pde10a 0.36765 phosphodiesterase L-phenylalanine transport in via Transport, PHEt4 phe__L_e + na1_e <-> phe__L_c + na1_c cytosol Slc38a4 0.52356 sodium symport Extracellular Transport, PROt4 Na+/Proline-L symporter na1_e + pro__L_e <-> na1_c + pro__L_c cytosol Slc38a4 0.52356 Extracellular 6-pyruvoyltetrahydropterin Tetrahydrobiopteri PTHPS ahdt_c <-> 6pthp_c + pppi_c cytosol Pts 1.64 synthase n Perillyl aldehyde:NAD+ pylald_c + nad_c + h2o_c <-> peracd_c + Limonene and PYLALDOX cytosol Aldh9a1 0.52356 oxidoreductase nadh_c + 2.0 h_c pinene degradation Transport, SERt4 L-serine via sodium symport na1_e + ser__L_e <-> na1_c + ser__L_c cytosol Slc38a4 0.52356 Extracellular s2l2n2m2mn_c + 2.0 h2o_c <-> l2n2m2mn_c N-Glycan SIAASE SIAASE cytosol Neu2 1.56 + 2.0 acnam_c Degradation S-Adenosyl-L- amet_c + srtn_c <-> nmthsrtn_c + ahcys_c + Tryptophan SRTNMTX methionine:amine N- cytosol Inmt 3.98 h_c metabolism methyltransferase (srtn) 4-trimethylaminobutyraldehyde nad_c + 4tmeabut_c + h2o_c <-> 2.0 h_c + Lysine TMABADH cytosol Aldh9a1 0.52356 dehydrogenase 4tmeabutn_c + nadh_c Metabolism Triiodothyronine triodthy_c + paps_c <-> pap_c + Tyrosine TRIODTHYSULT cytosol Sult1a1 1.62 Sulfotransferase triodthysuf_c + h_c metabolism Pentose and nadph_c + h_c + xylu__L_c <-> xylt_c + XYLUR Xylulose reductase Glucuronate cytosol Dcxr 1.73 nadp_c Interconversions Transport, extracellul ADPRIBt ADPribose transport adprib_e <-> adprib_c Cd38 0.54054 Extracellular ar Starch and Alpha-amylase, extracellular 8.0 h2o_e + strch1_e <-> strch2_e + 8.0 extracellul AMY1e Sucrose Amy1 1.98 (strch1 -> strch2) glc__D_e ar StarchMetabolism and Alpha-amylase, extracellular 8.0 h2o_e + glygn2_e <-> glygn4_e + 8.0 extracellul AMY2e Sucrose Amy1 1.98 (glygn2 -> glygn4) glc__D_e ar Metabolism extracellul NADNe NAD nucleosidase,extracellular h2o_e + nad_e <-> ncam_e + adprib_e + h_e NAD Metabolism Cd38 0.54054 ar Vitamin A extracellul RAI3 13-cis-retinoic acid isomerase retn_c <-> 13_cis_retn_c Gstm2 3.64 Metabolism ar Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksi_pre14_g <-> h_g + udp_g + Keratan sulfate B4galt1; G14T10g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, ksi_pre15_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksi_pre17_g <-> h_g + udp_g + Keratan sulfate B4galt1; G14T11g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, ksi_pre18_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksi_pre20_g <-> h_g + udp_g + Keratan sulfate B4galt1; G14T12g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, ksi_pre21_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksi_pre23_g <-> h_g + udp_g + Keratan sulfate B4galt1; G14T13g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, ksi_pre24_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksi_pre26_g <-> h_g + udp_g + Keratan sulfate B4galt1; G14T14g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, ksi_pre27_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksi_pre29_g <-> h_g + udp_g + Keratan sulfate B4galt1; G14T15g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, ksi_pre30_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksi_pre32_g <-> h_g + udp_g + Keratan sulfate B4galt1; G14T16g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, ksi_pre33_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksi_pre35_g <-> h_g + udp_g + Keratan sulfate B4galt1; G14T17g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, ksi_pre36_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide 2.0 udpgal_g + core4_g <-> 2.0 h_g + 2.0 Keratan sulfate B4galt1; G14T18g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, udp_g + ksii_core4_pre1_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksii_core4_pre3_g <-> h_g + Keratan sulfate B4galt1; G14T19g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, udp_g + ksii_core4_pre4_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksii_core4_pre6_g <-> h_g + Keratan sulfate B4galt1; G14T20g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, udp_g + ksii_core4_pre7_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksii_core4_pre9_g <-> h_g + Keratan sulfate B4galt1; G14T21g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, udp_g + ksii_core4_pre10_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksii_core2_pre1_g <-> h_g + Keratan sulfate B4galt1; G14T2g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, ksii_core2_pre2_g + udp_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksii_core2_pre3_g <-> h_g + Keratan sulfate B4galt1; G14T3g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, udp_g + ksii_core2_pre4_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksii_core2_pre6_g <-> h_g + Keratan sulfate B4galt1; G14T4g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, udp_g + ksii_core2_pre7_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksii_core2_pre9_g <-> h_g + Keratan sulfate B4galt1; G14T5g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, udp_g + ksii_core2_pre10_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksi_pre2_g <-> h_g + udp_g + Keratan sulfate B4galt1; G14T6g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, ksi_pre3_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksi_pre5_g <-> h_g + udp_g + Keratan sulfate B4galt1; G14T7g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, ksi_pre6_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksi_pre8_g <-> h_g + udp_g + Keratan sulfate B4galt1; G14T8g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, ksi_pre9_g biosynthesis B4galt5 Golgi Beta-N- acetylglucosaminylglycopeptide udpgal_g + ksi_pre11_g <-> h_g + udp_g + Keratan sulfate B4galt1; G14T9g golgi 0.55866;0.41667 beta-1,4-galactosyltransferase, ksi_pre12_g biosynthesis B4galt5 Golgi Beta-N- fn2m2masn_g + 2.0 udpgal_g <-> 2.0 udp_g + N-Glycan B4galt1; G14Tg acetylglucosaminylglycopeptide golgi 0.55866;0.41667 l2fn2m2masn_g + 2.0 h_g Biosynthesis B4galt5 beta-1,4-galactosyltransferase Sodium proton antiporter HNA Transport, NAt3_1 na1_c + h_e <-> h_c + na1_e golgi Slc9a2 0.62893 is 11 Extracellular Sodium/ammonium proton Transport, NAt5 nh4_e + na1_c <-> na1_e + nh4_c golgi Slc9a2 0.62893 antiporter Extracellular 3',5'-cyclic-nucleotide PDE1g camp_g + h2o_g <-> amp_g + h_g Nucleotides golgi Pde10a 0.36765 phosphodiesterase,Golgi 3',5'-cyclic-nucleotide PDE4g 35cgmp_g + h2o_g <-> h_g + gmp_g Nucleotides golgi Pde10a 0.36765 phosphodiesterase, Golgi Beta-galactoside alpha-2,3- cmpacna_g + core2_g <-> ksii_core2_pre1_g Keratan sulfate S23T2g golgi St3gal1 0.54945 sialyltransferase (core 2) + h_g + cmp_g biosynthesis Beta-galactoside alpha-2,3- cmpacna_g + ksii_core4_pre1_g <-> cmp_g + Keratan sulfate S23T4g golgi St3gal1 0.54945 sialyltransferase ksii_core4_pre2_g + h_g biosynthesis Beta-galactoside alpha-2,3- T_antigen_g + cmpacna_g <-> sT_antigen_g O-Glycan S23Tg golgi St3gal1 0.54945 sialyltransferase (T antigen) + h_g + cmp_g Biosynthesis UDPgalactose:D-glucose 4- udpgal_g + glc__D_g <-> h_g + udp_g + Galactose UGALGTg beta-D-galactosyltransferase, golgi B4galt1 0.55866 lcts_g metabolism Golgi apparatus 5- nad_m + 5hoxindact_m + h2o_m <-> 2.0 h_m Tryptophan mitochon 5HOXINDACTOXm Hydroxyindoleacetaldehyde:NA Aldh2 1.67 + nadh_m + 5hoxindoa_m metabolism dria D+ oxidoreductase (mito) N acetyl g glutamyl phosphate acg5p_m + h_m + nadph_m <-> acg5sa_m + Urea cycle/amino mitochon AGPRim reductase irreversible Aldh18a1 0.4065 nadp_m + pi_m group metabolism dria mitochondrial Glycine, Serine, gly_m + h_m + succoa_m <-> 5aop_m + mitochon ALASm 5 aminolevulinate synthase and Threonine Gcat 1.82 co2_m + coa_m dria Metabolism Glutamate mitochon ALATA_L L-alanine transaminase akg_c + ala__L_c <-> glu__L_c + pyr_c Gpt2 1.51 metabolism dria Aldehyde dehydrogenase h2o_m + id3acald_m + nad_m <-> 2.0 h_m + Tryptophan mitochon ALDD20xm indole 3 acetaldehyde NAD Aldh2 1.67 ind3ac_m + nadh_m metabolism dria mitochondrial Aldehyde dehydrogenase acald_m + h2o_m + nad_m <-> ac_m + 2.0 Glycolysis/Glucon mitochon ALDD2xm acetylaldehyde NAD Aldh2 1.67 h_m + nadh_m eogenesis dria mitochondrial Beta-Aminopropion nad_m + h2o_m + bamppald_m <-> nadh_m beta-Alanine mitochon BAMPPALDOXm aldehyde:NAD+ oxidoreductase Aldh2 1.67 + ala_B_m + 2.0 h_m metabolism dria (m) 3-Hydroxybutanoate:NAD+ Butanoate mitochon BDHm nad_m + bhb_m <-> h_m + acac_m + nadh_m Bdh1 0.67114 oxidoreductase, mitochondria Metabolism dria Urea cycle/amino mitochon CK ATP Creatine kinase creat_m + atp_m <-> adp_m + pcreat_m Ckmt2 0.51813 group metabolism dria Cyanide sulfurtransferase, Cysteine mitochon CYANSTm cyan_m + tsul_m <-> tcynt_m + so3_m + h_m Tst 1.9 mitochondrial Metabolism dria Glutamate-5-semialdehyde h_m + nadph_m + glu5p_m <-> nadp_m + Urea cycle/amino mitochon G5SDym Aldh18a1 0.4065 dehydrogenase, mitochondria pi_m + glu5sa_m group metabolism dria Glyoxylate and Glycolaldehyde dehydrogenase, nad_m + h2o_m + gcald_m <-> nadh_m + 2.0 mitochon Aldh2;Al GCALDDm Dicarboxylate 1.67;0.4065 mitochondrial h_m + glyclt_m dria dh18a1 Metabolism Ascorbate and D-Glucuronolactone:NAD+ glac_m + 2.0 h2o_m + nad_m <-> glcr_m + mitochon GLACOm Aldarate Aldh2 1.67 oxidoreductase, mitochondrial 3.0 h_m + nadh_m dria Metabolism Urea cycle/amino mitochon GLU5Km Glutamate 5-kinase (m) glu__L_m + atp_m <-> glu5p_m + adp_m Aldh18a1 0.4065 group metabolism dria Glutaryl-CoA dehydrogenase fad_m + h_m + glutcoa_m <-> fadh2_m + Tryptophan mitochon GLUTCOADHm Gcdh 1.6 (mitochondria) co2_m + b2coa_m metabolism dria Glycine, Serine, mitochon GLYATm Glycine C-acetyltransferase gly_m + accoa_m <-> 2aobut_m + coa_m and Threonine Gcat 1.82 dria Metabolism Imidazole acetaldeyde im4act_m + h2o_m + nad_m <-> im4ac_m + Histidine mitochon IMACTD_m Aldh2 1.67 dehydrogenase (mito) nadh_m + 2.0 h_m Metabolism dria Lactaldehyde dehydrogenase, nad_m + lald__D_m + h2o_m <-> nadh_m + Pyruvate mitochon Aldh2;Al LCADi_Dm 1.67;0.4065 mitochondrial 2.0 h_m + lac__D_m Metabolism dria dh18a1 Lactaldehyde dehydrogenase, nad_m + h2o_m + lald__L_m <-> 2.0 h_m + Pyruvate mitochon Aldh2;Al LCADm 1.67;0.4065 mitochondrial lac__L_m + nadh_m Metabolism dria dh18a1 Arginine and N4-Acetylaminobutanal:NAD+ nad_m + h2o_m + n4abutn_m <-> nadh_m + mitochon NABTNOm Proline Aldh2 1.67 oxidoreductase (m) 2.0 h_m + 4aabutn_m dria Metabolism NADP nadp_e + h2o_e <-> adprbp_e + ncam_e + mitochon NADPNe NAD Metabolism Cd38 0.54054 nucleosidase,extracellular h_e dria 2-oxoisovalerate dehydrogenase Valine, Leucine, nad_m + 4mop_m + coa_m <-> ivcoa_m + mitochon OIVD1m (acylating; 4-methyl-2- and Isoleucine Bckdhb 1.94 co2_m + nadh_m dria oxopentaoate), mitochondrial Metabolism 2-oxoisovalerate dehydrogenase Valine, Leucine, nad_m + coa_m + 3mob_m <-> co2_m + mitochon OIVD2m (acylating; 3-methyl-2- and Isoleucine Bckdhb 1.94 nadh_m + ibcoa_m dria oxobutanoate), mitochondrial Metabolism 2-oxoisovalerate dehydrogenase Valine, Leucine, coa_m + 3mop_m + nad_m <-> co2_m + mitochon OIVD3m (acylating; 3-methyl-2- and Isoleucine Bckdhb 1.94 2mbcoa_m + nadh_m dria oxopentanoate), mitochondrial Metabolism 5-beta-cholestane-3-alpha,7- nadph_m + o2_m + h_m + xoltriol_m <-> Bile Acid mitochon P45027A11m alpha,12-alpha-triol 27- Cyp27a1 1.59 xoltetrol_m + nadp_m + h2o_m Biosynthesis dria hydroxylase 5-beta-cholestane-3-alpha,7- xoltetrol_m + nadp_m <-> h_m + thcholst_m Bile Acid mitochon P45027A12m alpha,12-alpha-triol 27- Cyp27a1 1.59 + nadph_m Biosynthesis dria hydroxylase 5-beta-cholestane-3-alpha,7- nadph_m + o2_m + thcholst_m <-> nadp_m + Bile Acid mitochon P45027A13m alpha,12-alpha-triol 27- Cyp27a1 1.59 thcholstoic_m + h2o_m Biosynthesis dria hydroxylase 5-beta-cytochrome P450, family nadph_m + o2_m + h_m + xol7ah2_m <-> Bile Acid mitochon P45027A14m Cyp27a1 1.59 27, subfamily A, polypeptide 1 nadp_m + h2o_m + xol7ah3_m Biosynthesis dria 5-beta-cytochrome P450, family nadph_m + o2_m + h_m + xol7ah3_m <-> Bile Acid mitochon P45027A15m Cyp27a1 1.59 27, subfamily A, polypeptide 1 nadp_m + 2.0 h2o_m + xol7ah2al_m Biosynthesis dria o2_m + nadph_m + xol7ah2al_m <-> Bile Acid mitochon P45027A16m Cytochrome P450 27 Cyp27a1 1.59 dhcholestanate_m + nadp_m + h2o_m Biosynthesis dria chsterol_m + nadph_m + o2_m + h_m <-> Bile Acid mitochon P45027A1m Cytochrome P450 27 Cyp27a1 1.59 xol27oh_m + nadp_m + h2o_m Biosynthesis dria Perillyl aldehyde:NAD+ pylald_m + nad_m + h2o_m <-> nadh_m + Limonene and mitochon PYLALDOXm Aldh2 1.67 oxidoreductase (m) 2.0 h_m + peracd_m pinene degradation dria h_m + nadph_m + vitd2_m + o2_m <-> mitochon VITD2Hm Vitamin D-25-hydroxylase (D2) Vitamin D Cyp27a1 1.59 h2o_m + nadp_m + 25hvitd2_m dria o2_m + nadph_m + h_m + vitd3_m <-> mitochon VITD3Hm Vitamin D-25-hydroxylase (D3) Vitamin D Cyp27a1 1.59 nadp_m + h2o_m + 25hvitd3_m dria Histone-lysine N- Lysine LYSMTF1n amet_n + peplys_n <-> Nmelys_n + ahcys_n nucleus Dot1l 0.58824 methyltransferase, nuclear Metabolism Histone-lysine N- Nmelys_n + amet_n <-> Ndmelys_n + Lysine LYSMTF2n nucleus Dot1l 0.58824 methyltransferase, nuclear ahcys_n Metabolism Histone-lysine N- amet_n + Ndmelys_n <-> ahcys_n + Lysine LYSMTF3n nucleus Dot1l 0.58824 methyltransferase, nuclear Ntmelys_n Metabolism 6-pyruvoyltetrahydropterin Tetrahydrobiopteri PTHPSn ahdt_n <-> 6pthp_n + pppi_n nucleus Pts 1.64 synthase, nuclear n Xanthine dehydrogenase, h2o_x + nad_x + xan_x <-> urate_x + h_x + peroxisom XANDp Purine Catabolism Xdh 1.77 peroxisomal nadh_x e peroxisom XAO2x Xanthine oxidase hxan_x + o2_x + h2o_x <-> xan_x + h2o2_x Purine Catabolism Xdh 1.77 e peroxisom XAOx Xanthine oxidase,peroxisomal o2_x + h2o_x + xan_x <-> urate_x + h2o2_x Purine Catabolism Xdh 1.77 e L-Proline,2-oxoglutarate:oxygen Arginine and pro__L_r + o2_r + akg_r <-> co2_r + succ_r PROAKGOX1r oxidoreductase (4- Proline ribosome P4ha1 0.64516 + 4hpro_LT_r hydroxylating) (ER) Metabolism