Metabolic reactions containing cDEGs in the genome-based mouse metabolic network Compart Reaction ID Reaction Name Reaction Subsystem Genes Folds ment Bicarbonate transport Transport, 2HCO3_NAt na1_e + 2.0 hco3_e <-> 2.0 hco3_c + na1_c cytosol Slc4a4 0.55556 (Na/HCO3 1:2 cotransport) Extracellular Aldehyde dehydrogenase 3 4 34dhpac_c + h2o_c + nad_c <-> nadh_c + 2.0 Tyrosine 34DHALDD dihydroxyphenylacetaldehyde cytosol Aldh3a1 14.95 h_c + 34dhpha_c metabolism NAD 34DHPLACOX_NA 34DHPLACOX LPAREN h2o_c + 34dhpac_c + nadp_c <-> nadph_c + Tyrosine cytosol Aldh3a1 14.95 DP NADP RPAREN 2.0 h_c + 34dhpha_c metabolism 3,4- 34DHXMANDACO h2o_c + 34dhmald_c + nad_c <-> Tyrosine Dihydroxymandelaldehyde:NA cytosol Aldh3a1 14.95 X 34dhoxmand_c + nadh_c + 2.0 h_c metabolism D+ oxidoreductase Bicarbonate transport Transport, 3HCO3_NAt na1_e + 3.0 hco3_e <-> 3.0 hco3_c + na1_c cytosol Slc4a4 0.55556 (Na/HCO3 1:3 cotransport) Extracellular 3-Methoxy-4- 3mox4hpac_c + nad_c + h2o_c <-> Tyrosine 3M4HDXPAC hydroxyphenylacetaldehyde:NA cytosol Aldh3a1 14.95 homoval_c + nadh_c + 2.0 h_c metabolism D+ oxidoreductase 3-Methoxy-4- 3MOX4HOXPGALD h2o_c + nad_c + 3m4hpga_c <-> Tyrosine hydroxyphenylglycolaldehyde: cytosol Aldh3a1 14.95 OX 3mox4hoxm_c + nadh_c + 2.0 h_c metabolism NAD+ oxidoreductase 3-Methoxy-4- 3MOX4HOXPGALD h2o_c + 3m4hpga_c + nadp_c <-> nadph_c + Tyrosine hydroxyphenylglycolaldehyde: cytosol Aldh3a1 14.95 OX_NADP 3mox4hoxm_c + 2.0 h_c metabolism NADP+ oxidoreductase 4HOXPACDOX_NA 4HOXPACDOX LPAREN h2o_c + 4hoxpacd_c + nadp_c <-> 4hphac_c Tyrosine cytosol Aldh3a1 14.95 DP NADP RPAREN + nadph_c + 2.0 h_c metabolism 5- h2o_c + 5hoxindact_c + nad_c <-> Tryptophan 5HOXINDACTOX Hydroxyindoleacetaldehyde:NA cytosol Aldh9a1 0.52356 5hoxindoa_c + nadh_c + 2.0 h_c metabolism D+ oxidoreductase Aminobutyraldehyde 4abutn_c + h2o_c + nad_c <-> 4abut_c + 2.0 beta-Alanine ABUTD cytosol Aldh9a1 0.52356 dehydrogenase h_c + nadh_c metabolism ADNCYC Adenylate cyclase atp_c <-> camp_c + ppi_c Nucleotides cytosol Adcy7 0.52083 Transport, ALAt4 Alanine-Sodium symporter ala__L_e + na1_e <-> ala__L_c + na1_c cytosol Slc38a4 0.52356 Extracellular Aldehyde dehydrogenase pacald_c + nadp_c + h2o_c <-> nadph_c + Phenylalanine ALDD19x_P cytosol Aldh3a1 14.95 (phenylacetaldehyde, NADP) pac_c + 2.0 h_c metabolism Aldehyde dehydrogenase h2o_c + nad_c + pacald_c <-> 2.0 h_c + Phenylalanine ALDD19xr cytosol Aldh3a1 14.95 (phenylacetaldehyde, NAD) nadh_c + pac_c metabolism Aldehyde dehydrogenase nad_c + h2o_c + id3acald_c <-> 2.0 h_c + Tryptophan ALDD20x cytosol Aldh9a1 0.52356 (indole-3-acetaldehyde, NAD) nadh_c + ind3ac_c metabolism Aldehyde dehydrogenase acald_c + h2o_c + nad_c <-> ac_c + 2.0 h_c + Glycolysis/Glucon Aldh3a1; ALDD2x cytosol 14.95;0.52356 (acetaldehyde, NAD) nadh_c eogenesis Aldh9a1 Aldehyde dehydrogenase acald_c + h2o_c + nadp_c <-> ac_c + 2.0 h_c Glycolysis/Glucon Aldh3a1; ALDD2y cytosol 14.95;0.52356 (acetaldehyde, NADP) + nadph_c eogenesis Aldh9a1 Transport, ARGt5r ARGtiDF arg__L_e <-> arg__L_c cytosol Slc38a4 0.52356 Extracellular L-asparagine transport in via Transport, ASNt4 na1_e + asn__L_e <-> asn__L_c + na1_c cytosol Slc38a4 0.52356 sodium symport Extracellular Beta-Aminopropion aldehyde nad_c + h2o_c + bamppald_c <-> 2.0 h_c + beta-Alanine BAMPPALDOX cytosol Aldh9a1 0.52356 NAD+ oxidoreductase nadh_c + ala_B_c metabolism Glycine, Serine, Betaine-aldehyde betald_c + h2o_c + nad_c <-> glyb_c + 2.0 BETALDHx and Threonine cytosol Aldh9a1 0.52356 dehydrogenase h_c + nadh_c Metabolism Cys-Gly transport in via proton Transport, CGLYt3_2 2.0 h_e + cgly_e <-> cgly_c + 2.0 h_c cytosol Slc15a2 5.26 symport Extracellular Dihydropyrimidinase (5,6- Pyrimidine DHPM1 h2o_c + 56dura_c <-> cala_c + h_c cytosol Dpysl3 0.40984 dihydrouracil) Catabolism Transport, DOPAtu Dopamine uniport dopa_e <-> dopa_c cytosol Slc22a3 0.17331 Extracellular paps_c + estrone_c <-> pap_c + h_c + Steroid ESTSULT Estrogen sulfotransferase cytosol Sult1a1 1.62 estrones_c Metabolism atp_c + coa_c + ptdca_c <-> ppi_c + amp_c + Fatty acid FACOAL150 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ptdcacoa_c activation Fatty acid CoA ligase atp_c + coa_c + hdca_c <-> amp_c + Fatty acid FACOAL160 cytosol Acsl1 0.55249 hexadecanoate pmtcoa_c + ppi_c activation Fatty acid CoA ligase atp_c + coa_c + hdcea_c <-> amp_c + Fatty acid FACOAL161 cytosol Acsl1 0.55249 hexadecenoate hdcoa_c + ppi_c activation coa_c + hpdca_c + atp_c <-> hpdcacoa_c + Fatty acid FACOAL170 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation Fatty acid CoA ligase atp_c + coa_c + ocdca_c <-> amp_c + ppi_c + Fatty acid FACOAL180 cytosol Acsl1 0.55249 octadecanoate stcoa_c activation Fatty acid CoA ligase atp_c + coa_c + ocdcea_c <-> amp_c + Fatty acid FACOAL181 cytosol Acsl1 0.55249 octadecenoate odecoa_c + ppi_c activation coa_c + vacc_c + atp_c <-> vacccoa_c + Fatty acid FACOAL1812 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation atp_c + coa_c + elaid_c <-> od2coa_c + ppi_c Fatty acid FACOAL1813 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 + amp_c activation Linoleic acid:CoA ligase (AMP- atp_c + coa_c + lnlc_c <-> lnlccoa_c + ppi_c Fatty acid FACOAL1821 cytosol Acsl1 0.55249 forming) + amp_c activation lneldc_c + atp_c + coa_c <-> lneldccoa_c + Fatty acid FACOAL1822 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation Gamma-Linolenic acid:CoA atp_c + coa_c + lnlncg_c <-> ppi_c + Fatty acid FACOAL1831 cytosol Acsl1 0.55249 ligase (AMP-forming) lnlncgcoa_c + amp_c activation Alpha-Linolenic acid:CoA coa_c + lnlnca_c + atp_c <-> lnlncacoa_c + Fatty acid FACOAL1832 cytosol Acsl1 0.55249 ligase (AMP-forming) ppi_c + amp_c activation strdnc_c + atp_c + coa_c <-> strdnccoa_c + Fatty acid FACOAL184 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation atp_c + arach_c + coa_c <-> amp_c + Fatty acid FACOAL200 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 arachcoa_c + ppi_c activation atp_c + coa_c + dlnlcg_c <-> ppi_c + Fatty acid FACOAL203 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 dlnlcgcoa_c + amp_c activation coa_c + arachd_c + atp_c <-> arachdcoa_c + Fatty acid FACOAL204 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation coa_c + arachd_c + atp_c <-> arachdcoa_c + Fatty acid FACOAL204 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation eicostet_c + atp_c + coa_c <-> eicostetcoa_c Fatty acid FACOAL2042 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 + ppi_c + amp_c activation coa_c + tmndnc_c + atp_c <-> tmndnccoa_c + Fatty acid FACOAL205 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation coa_c + adrn_c + atp_c <-> adrncoa_c + Fatty acid FACOAL224 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation atp_c + coa_c + dcsptn1_c <-> dcsptn1coa_c Fatty acid FACOAL2251 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 + ppi_c + amp_c activation clpnd_c + coa_c + atp_c <-> clpndcoa_c + Fatty acid FACOAL2252 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation coa_c + atp_c + crvnc_c <-> c226coa_c + Fatty acid FACOAL226 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 amp_c + ppi_c activation atp_c + coa_c + lgnc_c <-> ppi_c + amp_c + Fatty acid FACOAL240 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 lgnccoa_c activation nrvnc_c + atp_c + coa_c <-> nrvnccoa_c + Fatty acid FACOAL241 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation atp_c + coa_c + tettet6_c <-> tettet6coa_c + Fatty acid FACOAL244_1 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation atp_c + coa_c + tetpent6_c <-> ppi_c + Fatty acid FACOAL245_1 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 amp_c + tetpent6coa_c activation tetpent3_c + atp_c + coa_c <-> tetpent3coa_c Fatty acid FACOAL245_2 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 + ppi_c + amp_c activation atp_c + coa_c + tethex3_c <-> tethex3coa_c + Fatty acid FACOAL246_1 Fatty-acid--CoA ligase cytosol Acsl1 0.55249 ppi_c + amp_c activation Fatty-acid--CoA ligase (n- atp_c + coa_c + hexc_c <-> hexccoa_c + Fatty acid FACOAL260 cytosol Acsl1 0.55249 C26:0) ppi_c + amp_c activation Glycerol-3-phosphate Glycolysis/Glucon G3PD2m dehydrogenase (FAD), fad_m + glyc3p_c <-> dhap_c + fadh2_m cytosol Gpd2 1.44 eogenesis mitochondrial Glyoxylate and gcald_c + h2o_c + nad_c <-> glyclt_c + 2.0 Aldh3a1; GCALDD Glycolaldehyde dehydrogenase Dicarboxylate cytosol 14.95;0.52356 h_c + nadh_c Aldh9a1 Metabolism Starch and Tyr_ggn_c + 8.0 udpg_c <-> 8.0 udp_c + GGNG Glycogenin self-glucosylation Sucrose cytosol Gyg 1.55 ggn_c + 8.0 h_c Metabolism Ascorbate and D-Glucuronolactone:NAD+ 2.0 h2o_c + glac_c + nad_c <-> nadh_c + 3.0 Aldh3a1; GLACO Aldarate cytosol 14.95;0.52356 oxidoreductase h_c + glcr_c Aldh9a1 Metabolism Starch and Glycogen synthase (ggn -> ggn_c + 3.0 udpg_c <-> 3.0 udp_c + 3.0 h_c + GLGNS1 Sucrose cytosol Gyg 1.55 glygn1) glygn1_c Metabolism atp_c + glu__L_c + nh4_c <-> adp_c + Glutamate GLNS Glutamine synthetase cytosol Glul 1.82 gln__L_c + h_c + pi_c metabolism L-glutamine reversible transport Transport, GLNt4 na1_e + gln__L_e <-> gln__L_c + na1_c cytosol Slc38a4 0.52356 via sodium symport Extracellular Urea cycle/amino GLYAMDTRc Glycine amidinotransferase (c) gly_c + arg__L_c <-> orn_c + gudac_c cytosol Gatm 0.60976 group metabolism Glycine transport via sodium Transport, GLYt4 na1_e + gly_e <-> gly_c + na1_c cytosol Slc38a4 0.52356 symport Extracellular Glycine, Serine, GNMT Glycine N-methyltransferase amet_c + gly_c <-> sarcs_c + h_c + ahcys_c and Threonine cytosol Gnmt 2.87 Metabolism 2.0 gthrd_e + h2o2_e <-> gthox_e + 2.0 Glutathione