Supplementary Table 1. Differentially expressed known genes (log ratio ≥1.5 or <-1.5) between TFs and NFs

Log Gene symbol Gene name Probe ID GenBank ratio Up-regulated genes FGFR2 fibroblast growth factor receptor 2 203638_s_at 6.8 NM_022969.1 KRTAP4-12 keratin associated protein 4-12 224269_at 6.6 BC004180.1 PKP2 plakophilin 2 207717_s_at 6.3 NM_004572.1 NFE2L3 nuclear factor (erythroid-derived 2)-like 3 236471_at 5.8 AI949827 IL32 interleukin 32 203828_s_at 5.6 NM_004221.1 RGS1 regulator of G-protein signalling 1 216834_at 5.4 S59049.1 HES4 hairy and enhancer of split 4 227347_x_at 5.4 NM_021170.1 CD14 CD14 molecule 201743_at 5.3 NM_000591.1 TFAP2C transcription factor AP-2 gamma 205286_at 5.2 U85658.1 BMP5 bone morphogenetic protein 5 205430_at 5.2 AL133386 TRPC4 transient receptor potential cation channel, subfamily C, member 4 224219_s_at 5.2 AF063825.1 MAB21L2 mab-21-like 2 (C. elegans) 210302_s_at 5.1 AF262032.1 WISP1 WNT1 inducible signaling pathway protein 1 211312_s_at 5.1 AB034725.1 GCNT2 glucosaminyl (N-acetyl) transferase 2 230788_at 5.0 BF059748 SLC12A1 solute carrier family 12 220281_at 4.9 AI632015 IGKC immunoglobulin kappa constant 221651_x_at 4.9 BC005332.1 SLC16A6 solute carrier family 16, member 6 207038_at 4.8 NM_004694.1 NRXN3 neurexin 3 205795_at 4.7 NM_004796.1 HSPB3 heat shock 27kDa protein 3 206375_s_at 4.7 NM_006308.1 HLA-DRA major histocompatibility complex, class II, DR alpha 208894_at 4.6 M60334.1 SORBS1 sorbin and SH3 domain containing 1 222513_s_at 4.6 N21458 FAM84A Family with sequence similarity 84, member A 234331_s_at 4.5 AK025063.1 ROBO2 Roundabout, axon guidance receptor, homolog 2 240425_x_at 4.5 R38403 LAMP3 lysosomal-associated membrane protein 3 205569_at 4.4 NM_014398.1 KRT14 keratin 14 209351_at 4.4 BC002690.1 FBN2 fibrillin 2 215717_s_at 4.4 X62009.1 NCOR1 nuclear receptor co-repressor 1 234313_at 4.4 AB028451.1 REPS2 RALBP1 associated Eps domain containing 2 227425_at 4.3 AI984607 RUFY2 RUN and FYVE domain containing 2 1569630_a_at 4.3 BC030097.1 C1orf115 chromosome 1 open reading frame 115 218546_at 4.2 NM_024709.1 WT1 Wilms tumor 1 206067_s_at 4.0 NM_024426.1 FZD9 frizzled homolog 9 207639_at 4.0 NM_003508.1 FGF18 fibroblast growth factor 18 211029_x_at 4.0 BC006245.1 IFI6 interferon, alpha-inducible protein 6 211430_s_at 4.0 M87789.1 GNRHR gonadotropin-releasing hormone receptor 211523_at 4.0 L07949.1 EPC1 enhancer of polycomb homolog 1 223875_s_at 4.0 AF277374.1 nuclear factor of activated T-cells, cytoplasmic, NFATC1 209664_x_at 3.8 AW027545 calcineurin-dependent 1 IL8 interleukin 8 211506_s_at 3.8 AF043337.1 COL10A1 collagen, type X, alpha 1 217428_s_at 3.8 X98568 CXCL14 chemokine (C-X-C motif) ligand 14 222484_s_at 3.8 AF144103.1 ANKRD1 ankyrin repeat domain 1 206029_at 3.7 NM_014391.1 DSP desmoplakin 200606_at 3.6 NM_004415.1 SRGN serglycin 201858_s_at 3.6 J03223.1 ICAM1 intercellular adhesion molecule 1 (CD54) 202637_s_at 3.6 AI608725 RSG4 regulator of G-protein signalling 4 204337_at 3.6 AL514445 IL24 interleukin 24 206569_at 3.6 NM_006850.1 IL1A interleukin 1, alpha 210118_s_at 3.6 M15329.1 NLGN4X neuroligin 4, X-linked 221933_at 3.6 AI338338 CLDN1 Claudin 1 222549_at 3.5 AF101051.1 NLRP1 NLR family, pyrin domain containing 1 211824_x_at 3.4 AF229062.1 PPBP pro-platelet basic protein 214146_s_at 3.4 R64130 CDH1 cadherin 1 201131_s_at 3.3 NM_004360.1 RGS4 regulator of G-protein signalling 4 204338_s_at 3.3 NM_005613.2 IL1B interleukin 1, beta 205067_at 3.3 NM_000576.1 SLC7A2 solute carrier family 7, member 2 225516_at 3.3 AA876372 PAPPA pregnancy-associated plasma protein A 201982_s_at 3.2 NM_002581.1 CHRNA1 cholinergic receptor, nicotinic, alpha 1 206633_at 3.2 NM_000079.1 EFNB2 ephrin-B2 202668_at 3.1 BF00167 IL6 interleukin 6 205207_at 3.1 NM_000600.1 S100A8 S100 calcium binding protein A8 202917_s_at 3.0 NM_002964.2 HDAC9 histone deacetylase 9 205659_at 3.0 NM_014707.1 RASGRP2 RAS guanyl releasing protein 2 208206_s_at 3.0 NM_005825.1 NMES1 normal mucosa of esophagus specific 1 223484_at 3.0 AF228422.1 NOPE neighbor of Punc E11 227870_at 3.0 AB046848.1 KRT19 keratin 19 201650_at 2.9 NM_002276.1 FLI1 Friend leukemia virus integration 1 204236_at 2.9 NM_002017.2 SERPINB2 serpin peptidase inhibitor, clade B, member 2 204614_at 2.9 NM_002575.1 FABP3 fatty acid binding protein 3 205738_s_at 2.8 NM_004102.2 TNFSF4 tumor necrosis factor superfamily, member 4 207426_s_at 2.8 NM_003326.1 IGLJ3 immunoglobulin lambda joining 3 214677_x_at 2.8 X57812.1 PTPRE protein tyrosine phosphatase, receptor type, E 221840_at 2.8 AA775177 SRGN serglycin 201859_at 2.7 NM_002727.1 IL8 interleukin 8 202859_x_at 2.7 NM_000584.1 CHI3L1 chitinase 3-like 1 209396_s_at 2.7 M80927.1 SULF2 sulfatase 2 224724_at 2.7 AL133001.1 CF1 complement factor I 1555564_a_at 2.7 BC020718.1 TFAP2A transcription factor AP-2 alpha 204653_at 2.6 BF343007 OXTR oxytocin receptor 206825_at 2.6 NM_000916.2 LYZ lysozyme 213975_s_at 2.6 AV711904 SORBS1 sorbin and SH3 domain containing 1 218087_s_at 2.6 NM_015385.1 SLC24A3 solute carrier family 24, member 3 57588_at 2.6 R62432 FNDC1 fibronectin type III domain containing 1 226930_at 2.6 AI345957 HBEGF heparin-binding EGF-like growth factor 203821_at 2.5 NM_001945.1 ICAM4 intercellular adhesion molecule 4 207194_s_at 2.5 NM_001544.2 TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 207641_at 2.5 NM_012452.1 CHI3L1 chitinase 3-like 1 209395_at 2.5 M80927.1 FABP3 fatty acid binding protein 3, 214285_at 2.5 AI041520 PPP1R14A protein phosphatase 1, regulatory subunit 14A 227006_at 2.5 AA156998 ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 233785_at 2.5 AB037733.1 PPAPDC1A phosphatidic acid phosphatase type 2 domain containing 1A 236044_at 2.5 BF130943 EGR2 early growth response 2 205249_at 2.4 NM_000399.2 SEMA5A semaphorin 5A 205405_at 2.4 NM_003966.1 WNT2 wingless-type MMTV integration site family member 2 205648_at 2.4 NM_003391.1 IL11 interleukin 11 206924_at 2.4 NM_000641.1 INHBA inhibin, beta A 210511_s_at 2.4 M13436.1 SST somatostatin 213921_at 2.4 NM_001048.1 FRS2 fibroblast growth factor receptor substrate 2 221308_at 2.4 NM_006654.1 SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 244461_at 2.4 AI539783 GPR116 G protein-coupled receptor 116 212950_at 2.3 BF941499 TNC Tenascin C 216005_at 2.3 BF434846 LOC653879 similar to Complement C3 precursor 217767_at 2.3 NM_000064.1 NRP2 neuropilin 2 225566_at 2.3 AI819729 PRDM1 PR domain containing 1, with ZNF domain 228964_at 2.3 AI692659 KRT34 keratin 34 206969_at 2.2 NM_021013.2 IGL Immunoglobulin lambda locus 209138_x_at 2.2 M87790.1 LAMB3 laminin, beta 3 209270_at 2.2 L25541.1 PDZD2 PDZ domain containing 2 209493_at 2.2 AF338650.1 NR4A3 nuclear receptor subfamily 4, group A, member 3 209959_at 2.2 U12767.1 F2RL1 coagulation factor II receptor-like 1 213506_at 2.2 BE965369 CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta 3 subunit 219714_s_at 2.2 NM_018398.1 ST6GALNAC5 ST6-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 220979_s_at 2.2 NM_030965.1 LEF1 lymphoid enhancer-binding factor 1 221558_s_at 2.2 AF288571.1 GUCY1A3 guanylate cyclase 1, soluble, alpha 3 221942_s_at 2.2 AI719730 SFN stratifin 33323_r_at 2.2 X57348 NETO1 neuropilin and tolloid -like 1 1552736_a_at 2.2 NM_138966.2 COL11A1 collagen, type XI, alpha 1 204320_at 2.1 NM_001854.1 WNT5A wingless-type MMTV integration site family, member 5A 205990_s_at 2.1 NM_003392.1 ANK3 ankyrin 3 206385_s_at 2.1 NM_020987.1 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 207691_x_at 2.1 NM_001776.1 C8orf4 chromosome 8 open reading frame 4 218541_s_at 2.1 NM_020130.1 TNFSF18 tumor necrosis factor superfamily, member 18 221371_at 2.1 NM_005092.1 CPXM2 carboxypeptidase X, member 2 236144_at 2.1 BF726934 IFNE1 interferon epsilon 1 1553574_at 2.1 NM_176891.1 neural precursor cell expressed, developmentally down-regulated NEDD9 202149_at 2.0 AL136139 9 IGFBP2 insulin-like growth factor binding protein 2 202718_at 2.0 NM_000597.1 KRT17 keratin 17 205157_s_at 2.0 NM_000422.1 JAG2 jagged 2 209784_s_at 2.0 AF029778.1 PTGDS prostaglandin D2 synthase 211748_x_at 2.0 BC005939.1 COL4A6 collagen, type IV, alpha 6 213992_at 2.0 AI889941 PALM2 paralemmin 2 1554640_at 2.0 BC039306.1 ENC1 ectodermal-neural cortex 201341_at 1.9 NM_003633.1 ANXA8 annexin A8 203074_at 1.9 NM_001630.1 SHROOM2 shroom family member 2 204967_at 1.9 NM_001649.1 PDGFA platelet-derived growth factor alpha polypeptide 205463_s_at 1.9 NM_002607.1 HMGCS1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 205822_s_at 1.9 NM_002130.1 FMO3 flavin containing monooxygenase 3 206496_at 1.9 NM_006894.2 MXRA5 matrix-remodelling associated 5 209596_at 1.9 AF245505.1 FZD8 frizzled homolog 8 224325_at 1.9 AB043703.1 ERRFI1 ERBB receptor feedback inhibitor 1 224657_at 1.9 AL034417 CNTN3 contactin 3 229831_at 1.9 BE221817 KRT18 keratin 18 201596_x_at 1.8 NM_000224.1 S100A2 S100 calcium binding protein A2 204268_at 1.8 NM_005978.2 MRC1 mannose receptor, C type 1 204438_at 1.8 NM_002438.1 RASGRP1 RAS guanyl releasing protein 1 205590_at 1.8 NM_005739.2 MMP10 matrix metallopeptidase 10 205680_at 1.8 NM_002425.1 PITX2 paired-like homeodomain 2 207558_s_at 1.8 NM_000325.1 CADM1 cell adhesion molecule 1 209031_at 1.8 AL519710 ALDH1B1 aldehyde dehydrogenase 1 family, member B1 209645_s_at 1.8 NM_000692.1 ABI3BP ABI gene family, member 3 (NESH) binding protein 223395_at 1.8 AB056106.1 HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 227361_at 1.8 AA780067 BHLHB2 basic helix-loop-helix domain containing, class B, 2 201170_s_at 1.7 NM_003670.1 TACSTD2 tumor-associated calcium signal transducer 2 202286_s_at 1.7 J04152 CDH13 cadherin 13 204726_at 1.7 NM_001257.1 F2RL1 coagulation factor II (thrombin) receptor-like 1 206429_at 1.7 NM_005242.2 A2M alpha-2-macroglobulin 217757_at 1.7 NM_000014.3 NOX4 NADPH oxidase 4 219773_at 1.7 NM_016931.1 ELOVL2 elongation of very long chain fatty acids -like 2 220029_at 1.7 NM_017770.1 LMCD1 LIM and cysteine-rich domains 1 227317_at 1.7 AA045042 FN1 fibronectin 1 1558199_at 1.7 W73431 MFAP2 microfibrillar-associated protein 2 203417_at 1.6 NM_017459.1 HMOX1 heme oxygenase (decycling) 1 203665_at 1.6 NM_002133.1 MMP1 matrix metallopeptidase 1 204475_at 1.6 NM_002421.2 QPCT glutaminyl-peptide cyclotransferase 205174_s_at 1.6 NM_012413.2 HBE1 hemoglobin, epsilon 1 205919_at 1.6 NM_005330.2 LRRN3 leucine rich repeat neuronal 3 209840_s_at 1.6 AI221950 ATP10A ATPase, Class V, type 10A 214255_at 1.6 N35112 CNTN1 Contactin 1 227209_at 1.6 AI091445 MATN2 matrilin 2 202350_s_at 1.5 NM_002380.2 SFRP4 secreted frizzled-related protein 4 204051_s_at 1.5 NM_003014.2 COL7A1 collagen, type VII, alpha 1 204136_at 1.5 NM_000094.1 KAL1 Kallmann syndrome 1 sequence 205206_at 1.5 NM_000216.1 AREG schwannoma-derived growth factor 205239_at 1.5 NM_001657.1 SCRG1 scrapie responsive protein 1 205475_at 1.5 NM_007281.1 ADAM19 ADAM metallopeptidase domain 19 209765_at 1.5 AF311317.1 CXCL2 chemokine (C-X-C motif) ligand 2 209774_x_at 1.5 M57731.1 potassium large conductance calcium-activated channel, subfamily 1.5 KCNMB1 209948_at U61536.1 M, beta member 1 SCD stearoyl-CoA desaturase 211708_s_at 1.5 BC005807.1 TMEM2 transmembrane protein 2 218113_at 1.5 NM_013390.1 COL5A3 collagen, type V, alpha 3 218975_at 1.5 NM_015719.1 SFRP2 secreted frizzled-related protein 2 223122_s_at 1.5 AF311912.1 RGS5 regulator of G-protein signaling 5 1555725_a_at 1.5 AF493929.1 Down-regulated genes ISL1 ISL1 transcription factor 206104_at -4.0 NM_002202.1 FOS v-fos FBJ murine osteosarcoma viral oncogene homolog 209189_at -3.8 BC004490.1 NF2 neurofibromin 2 204991_s_at -3.6 NM_000268.1 CPVL carboxypeptidase, vitellogenic-like 208146_s_at -3.3 NM_031311.1 ALDH1 aldehyde dehydrogenase 1 212224_at -3.2 NM_000689.1 CYP1A1 cytochrome P450, family 1 205749_at -3.0 NM_000499.2 HIST1H4K histone cluster 1, H4k 208580_x_at -3.0 NM_021968.1 ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 1553180_at -3.0 NM_133638.1 TRAIP TRAF interacting protein 205598_at -2.9 NM_005879.1 CYTL1 cytokine-like 1 219837_s_at -2.8 NM_018659.1 NFIX nuclear factor I/X 228278_at -2.8 AI817698 CORO1A coronin, actin binding protein, 1A 209083_at -2.6 U34690.1 CDC25A cell division cycle 25 homolog A 204695_at -2.5 AI343459 BARX1 BarH-like homeobox 1 219845_at -2.4 NM_021570.2 EBF3 early B-cell factor 3 227242_s_at -2.4 BF592034 SESN3 sestrin 3 235683_at -2.3 BF685808 ADRB2 adrenergic beta-2-receptor 206170_at -2.2 NM_000024.2 E2F8 E2F transcription factor 8 219990_at -2.2 NM_024680.1 NPTX1 neuronal pentraxin I 204684_at -2.1 NM_002522.1 HMMR hyaluronan-mediated motility receptor 207165_at -2.1 NM_012485.1 SLC16A14 solute carrier family 16, member 14 238029_s_at -2.1 R15072 CENPE centromere protein E 205046_at -2.0 NM_001813.1 CRIP1 cysteine-rich protein 1 205081_at -2.0 NM_001311.1 CPM carboxypeptidase M 206100_at -2.0 NM_001874.1 BRCA2 breast cancer 2, early onset 208368_s_at -2.0 NM_000059.1 TSHB thyroid stimulating hormone, beta 214529_at -2.0 NM_000549.1 KIF15 kinesin family member 15 219306_at -2.0 NM_020242.1 DEPDC1 DEP domain containing 1 232278_s_at -2.0 AJ278112.1 TOP2A topoisomerase (DNA) II alpha 170kDa 201291_s_at -1.9 AU159942 CCNA2 cyclin A2 203418_at -1.9 NM_001237.1 BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog 209642_at -1.9 AF043294.2 NCAPH non-SMC condensin I complex, subunit H 212949_at -1.9 D38553.1 BUB1B BUB1 budding uninhibited by benzimidazoles 1 homolog beta 203755_at -1.8 NM_001211.2 DLG7 discs, large homolog 7 203764_at -1.8 NM_014750.1 GTSE1 G-2 and S-phase expressed 1 204318_s_at -1.8 NM_016426.1 TTK TTK protein kinase 204822_at -1.8 NM_003318.1 CDC2 cell division cycle 2, G1 to S and G2 to M 210559_s_at -1.8 D88357.1 NCAPG non-SMC condensin I complex, subunit G 218663_at -1.8 NM_022346.1 PBK PDZ binding kinase 219148_at -1.8 NM_018492.1 ASPM asp (abnormal spindle) homolog, microcephaly associated 219918_s_at -1.8 NM_018123.1 CDCA3 cell division cycle associated 3 221436_s_at -1.8 NM_031299.1 NEFL neurofilament, light polypeptide 68kDa 221805_at -1.8 AL537457 DEPDC1 DEP domain containing 1 222958_s_at -1.8 AK000490.1 DEPDC1B DEP domain containing 1B 226980_at -1.8 AK001166.1 TSPAN2 tetraspanin 2 227233_at -1.8 AU147132 KIF14 kinesin family member 14 236641_at -1.8 AW183154 LIG1 ligase I, DNA, ATP-dependent 202726_at -1.7 NM_000234.1 RAD51AP1 RAD51 associated protein 1 204146_at -1.7 BE966146 NDC80 NDC80 homolog, kinetochore complex component 204162_at -1.7 NM_006101.1 BRCA1 breast cancer 1, early onset 204531_s_at -1.7 NM_007295.1 PSG5 pregnancy specific beta-1-glycoprotein 5 204830_x_at -1.7 NM_002781.1 CRLF1 cytokine receptor-like factor 1 206315_at -1.7 NM_004750.1 C18orf24 chromosome 18 open reading frame 24 217640_x_at -1.7 BF038461 CEP55 centrosomal protein 55kDa 218542_at -1.7 NM_018131.1 KIF20A kinesin family member 20A 218755_at -1.7 NM_005733.1 RAI2 retinoic acid induced 2 219440_at -1.7 NM_021785.2 MCM10 minichromosome maintenance complex component 10 220651_s_at -1.7 NM_018518.1 STXBP6 syntaxin binding protein 6 (amisyn) 220994_s_at -1.7 NM_014178.1 FAM64A family with sequence similarity 64, member A 221591_s_at -1.7 BC005004.1 C1QTNF2 C1q and tumor necrosis factor related protein 2 223749_at -1.7 AF329836.1 CDCA2 cell division cycle associated 2 226661_at -1.7 T90295 CCNB1 cyclin B1 228729_at -1.7 N90191 UDP-N-acetyl-alpha-D-galactosamine:polypeptide GALNT13 234472_at -1.7 AC009227 N-acetylgalactosaminyltransferase 13 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 235368_at -1.7 AI123555 SGOL2 shugoshin-like 2 235425_at -1.7 AW965339 ANLN anillin, actin binding protein 1552619_a_at -1.7 NM_018685.1 BIRC5 baculoviral IAP repeat-containing 5 202095_s_at -1.6 NM_001168.1 CCNB2 cyclin B2 202705_at -1.6 NM_004701.2 RASSF2 Ras association (RalGDS/AF-6) domain family 2 203185_at -1.6 NM_014737.1 RFC5 replication factor C (activator 1) 5 203210_s_at -1.6 NM_007370.1 RFC3 replication factor C (activator 1) 3 204128_s_at -1.6 NM_002915.1 FGL2 fibrinogen-like 2 204834_at -1.6 NM_006682.1 PLK4 polo-like kinase 4 204887_s_at -1.6 NM_014264.1 CENPA centromere protein A 204962_s_at -1.6 NM_001809.2 CDC25C cell division cycle 25 homolog C 205167_s_at -1.6 NM_001790.2 SLC7A11 solute carrier family 7, member 11 207528_s_at -1.6 NM_014331.1 CENPF centromere protein F 207828_s_at -1.6 NM_005196.1 KRT7 keratin 7 209016_s_at -1.6 BC002700.1 HMMR hyaluronan-mediated motility receptor 209709_s_at -1.6 U29343.1 TACC3 transforming, acidic coiled-coil containing protein 3 218308_at -1.6 NM_006342.1 DTL denticleless homolog 218585_s_at -1.6 NM_016448.1 EDN1 endothelin 1 218995_s_at -1.6 NM_001955.1 CDCA8 cell division cycle associated 8 221520_s_at -1.6 BC001651.1 ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 222486_s_at -1.6 AF060152.1 UBE2T ubiquitin-conjugating enzyme E2T 223229_at -1.6 AB032931.1 NUF2 NUF2, NDC80 kinetochore complex component, homolog 223381_at -1.6 AF326731.1 CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 223385_at -1.6 AF335278.1 TMTC1 transmembrane and tetratricopeptide repeat containing 1 224397_s_at -1.6 AF319520.1 PSRC1 proline/serine-rich coiled-coil 1 201896_s_at -1.5 BC001425.1 SFRP1 secreted frizzled-related protein 1 202035_s_at -1.5 AI332407 CDC20 cell division cycle 20 202870_s_at -1.5 NM_001255.1 UBCH10 ubiquitin carrier protein E2-C 202954_at -1.5 NM_007019.1 MAD2L1 MAD2 (mitotic arrest deficient, yeast, homolog)-like 1 203362_s_at -1.5 NM_002358.2 KIF11 kinesin family member 11 204444_at -1.5 NM_004523.2 KIF23 kinesin family member 23 204709_s_at -1.5 NM_004856.3 CCNE2 cyclin E2 205034_at -1.5 NM_004702.1 IL13RA2 interleukin 13 receptor, alpha 2 206172_at -1.5 NM_000640.1 COLEC10 collectin sub-family member 10 207420_at -1.5 NM_006438.1 KIFC1 kinesin family member C1 209680_s_at -1.5 BC000712.1 CDKN3 cyclin-dependent kinase inhibitor 3 209714_s_at -1.5 AF213033.1 SPC25 NDC80 kinetochore complex component, homolog 209891_at -1.5 AF225416.1 FANCI Fanconi anemia, complementation group I 213007_at -1.5 W74442 OIP5 Opa interacting protein 5 213599_at -1.5 BE045993 MYBL1 v-myb myeloblastosis viral oncogene homolog (avian)-like 1 213906_at -1.5 AW592266 KYNU kynureninase 217388_s_at -1.5 D55639.1 PRC1 protein regulator of cytokinesis 1 218009_s_at -1.5 NM_003981.1 NUSAP1 nucleolar and spindle associated protein 1 218039_at -1.5 NM_016359.1 DTL denticleless homolog 222680_s_at -1.5 AK001261.1 CASC5 cancer susceptibility candidate 5 228323_at -1.5 BF248364 CNTN4 contactin 4 229084_at -1.5 R42166 TSPAN12 tetraspanin 12 230626_at -1.5 AI056699

Supplementary Table 2. Differentially expressed genes related to cell proliferation in TFs.

Gene name Log ratio GenBank # Up-regulated genes FGFR2 Fibroblast growth factor receptor 2 6.8 NM_022969.1 RGS1 Regulator of G-protein signalling 1 5.4 S59049.1 TFAP2C Transcription factor AP-2 gamma 5.2 U85658.1 LAMP3 Lysosomal-associated membrane protein 3 4.4 NM_014398.1 NCOR1 Nuclear receptor co-repressor 1 4.4 AB028451.1 WT1 Wilms tumor 1 4.0 NM_024426.1 FGF18 Fibroblast growth factor 18 4.0 BC006245.1 RSG4 Regulator of G-protein signalling 4 3.6 AL514445 PPBP Pro-platelet basic protein 3.4 R64130 LHX6 LIM homeobox 6 3.3 NM_014368.1 WISP1 WNT1 inducible signaling pathway protein 1 3.1 NM_003882.1 HDAC9 Histone deacetylase 9 3.0 NM_014707.1 RASGRP2 RAS guanyl releasing protein 2 3.0 NM_005825.1 TAF4 TATA box binding protein (TBP)-associated factor 4 3.0 NM_003185.1 FLI1 Friend leukemia virus integration 1 2.9 NM_002017.2 TRPC4 Transient receptor potential cation channel, subfamily C, member 4 2.8 NM_016179.1 TFAP2A Transcription factor AP-2 alpha 2.6 BF343007 HBEGF Heparin-binding EGF-like growth factor 2.5 NM_001945.1 WNT2 Wingless-type MMTV integration site family member 2 2.4 NM_003391.1 FRS2 Fibroblast growth factor receptor substrate 2 2.4 NM_006654.1 NR4A3 Nuclear receptor subfamily 4, group A, member 3 2.2 U12767.1 F2RL1 Coagulation factor II receptor-like 1 2.2 BE965369 LEF1 Lymphoid enhancer-binding factor 1 2.2 AF288571.1 SFN Stratifin 2.2 X57348 NFE2L3 Nuclear factor (erythroid-derived 2)-like 3 2.1 NM_004289.3 WNT5A Wingless-type MMTV integration site family, member 5A 2.1 NM_003392.1 IGFBP2 Insulin-like growth factor binding protein 2 2.0 NM_000597.1 CDK5R1 Cyclin-dependent kinase 5, regulatory subunit 1 (p35) 2.0 AL567411 JAG2 Jagged 2 2.0 AF029778.1 PDGFA platelet-derived growth factor alpha polypeptide 1.9 NM_002607.1 PITX2 paired-like homeodomain 2 1.8 NM_000325.1 BHLHB2 basic helix-loop-helix domain containing, class B, 2 1.7 NM_003670.1 TACSTD2 tumor-associated calcium signal transducer 2 1.7 J04152 F2RL1 coagulation factor II (thrombin) receptor-like 1 1.7 NM_005242.2 NOX4 NADPH oxidase 4 1.7 NM_016931.1 AREG schwannoma-derived growth factor 1.5 NM_001657.1 RGS5 regulator of G-protein signaling 5 1.5 AF493929.1 Down-regulated genes ISL1 ISL1 transcription factor -4.0 NM_002202.1 NF2 Neurofibromin 2 -3.6 NM_000268.1 TCF7L2 Transcription factor 7-like 2 -2.8 BF696202 CENPF Centromere protein F -2.7 NM_016343.1 CDC25A Cell division cycle 25 homolog A -2.5 AI343459 E2F8 E2F transcription factor 8 -2.2 NM_024680.1 CENPE Centromere protein E -2.0 NM_001813.1 BRCA2 Breast cancer 2, early onset -2.0 NM_000059.1 BRCA1b Breast cancer 1, transcript variant BRCA1b -2.0 NM_007295.1 CCNA2 cyclin A2 -1.9 NM_001237.1 GTSE1 G-2 and S-phase expressed 1 -1.8 NM_016426.1 CDC2 cell division cycle 2, G1 to S and G2 to M -1.8 D88357.1 CDCA3 cell division cycle associated 3 -1.8 NM_031299.1 BRCA1 breast cancer 1, early onset -1.7 NM_007295.1 CEP55 centrosomal protein 55kDa -1.7 NM_018131.1 CDCA2 cell division cycle associated 2 -1.7 T90295 CCNB2 cyclin B2 -1.6 NM_004701.2 RASSF2 Ras association (RalGDS/AF-6) domain family 2 -1.6 NM_014737.1 CDC25C cell division cycle 25 homolog C -1.6 NM_001790.2 CENPF centromere protein F -1.6 NM_005196.1 CDCA8 cell division cycle associated 8 -1.6 BC001651.1 CDC20 cell division cycle 20 -1.5 NM_001255.1 MAD2L1 MAD2 (mitotic arrest deficient, yeast, homolog)-like 1 -1.5 NM_002358.2 CDKN3 cyclin-dependent kinase inhibitor 3 -1.5 AF213033.1

Supplementary Table 3. Differentially expressed genes associated with extracellular matrix in TFs. Gene Name Log Ratio GenBank # Up-regulated genes PKP2 Plakophilin 2 6.3 NM_004572.1 SORBS1 Sorbin and SH3 domain containing 1 4.6 N21458 FBN2 Fibrillin 2 4.4 X62009.1 NRXN3 Neurexin 3 3.9 AF123462 ICAM1 Intercellular adhesion molecule 1 (CD54) 3.6 AI608725 NLGN4X Neuroligin 4, X-linked 3.6 AI338338 CLDN1 Claudin 1 3.5 AF101051.1 COL10A1 Collagen, type X, alpha 1 3.4 AI376003 CDH1 Cadherin 1 3.3 NM_004360.1 CLDN14 Claudin 14 3.3 AF314090.1 CXADR Coxsackie virus and adenovirus receptor 3.3 AY072911.1 NOPE Neighbor of Punc E11 3.0 AB046848.1 ICAM4 Intercellular adhesion molecule 4 2.5 NM_001544.2 ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.5 AB037733.1 SEMA5A Semaphorin 5A 2.4 NM_003966.1 TNC Tenascin C 2.3 BF434846 NRP2 Neuropilin 2 2.3 AI819729 LAMB3 Laminin, beta 3 2.2 L25541.1 PDZD2 PDZ domain containing 2 2.2 AF338650.1 COL11A1 Collagen, type XI, alpha 1 2.1 NM_001854.1 COL4A6 Collagen, type IV, alpha 6 2.0 AI889941 MXRA5 matrix-remodelling associated 5 1.9 AF245505.1 FZD8 frizzled homolog 8 1.9 AB043703.1 CNTN3 contactin 3 1.9 BE221817 MMP10 matrix metallopeptidase 10 1.8 NM_002425.1 CADM1 cell adhesion molecule 1 1.8 AL519710 CDH13 cadherin 13 1.7 NM_001257.1 FN1 fibronectin 1 1.7 W73431 MFAP2 microfibrillar-associated protein 2 1.6 NM_017459.1 MMP1 matrix metallopeptidase 1 1.6 NM_002421.2 CNTN1 Contactin 1 1.6 AI091445 MATN2 matrilin 2 1.5 NM_002380.2 SFRP4 secreted frizzled-related protein 4 1.5 NM_003014.2 COL7A1 collagen, type VII, alpha 1 1.5 NM_000094.1 SCRG1 scrapie responsive protein 1 1.5 NM_007281.1 ADAM19 ADAM metallopeptidase domain 19 1.5 AF311317.1 COL5A3 collagen, type V, alpha 3 1.5 NM_015719.1 Down-regulated genes ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -3.0 NM_133638.1 SFRP1 secreted frizzled-related protein 1 -1.5 AI332407 CNTN4 contactin 4 -1.5 R42166

Supplementary Table 4. Differentially expressed genes associated with immune response in TFs. Gene Name Log Ratio GenBank # Up-regulated genes IL32 Interleukin 32 5.6 NM_004221.1 CD14 CD14 molecule 5.3 NM_000591.1 IGKC Immunoglobulin kappa constant 4.9 BC005332.1 HLA-DRA Major histocompatibility complex, class II, DR alpha 4.6 M60334.1 IFI6 Interferon, alpha-inducible protein 6 4.0 M87789.1 NFATC1 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 3.8 AW027545 IL8 Interleukin 8 3.8 AF043337.1 CXCL14 Chemokine (C-X-C motif) ligand 14 3.8 AF144103.1 IL24 Interleukin 24 3.6 NM_006850.1 IL1A Interleukin 1, alpha 3.6 M15329.1 IL1B Interleukin 1, beta 3.3 NM_000576.1 S100A8 S100 calcium binding protein A8 3.0 NM_002964.2 TNFSF4 Tumor necrosis factor superfamily, member 4 2.8 NM_003326.1 IGLJ3 Immunoglobulin lambda joining 3 2.8 X57812.1 CF1 Complement factor I 2.7 BC020718.1 CCL5 Chemokine (C-C motif) ligand 5 2.6 NM_002985.1 TNFRSF13B Tumor necrosis factor receptor superfamily, member 13B 2.5 NM_012452.1 FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 2.5 X14355.1 IL11 Interleukin 11 2.4 NM_000641.1 TNFSF18 Tumor necrosis factor superfamily, member 18 2.1 NM_005092.1 IFNE1 Interferon epsilon 1 2.1 NM_176891.1 CXCL2 chemokine (C-X-C motif) ligand 2 1.5 M57731.1 Down-regulated genes SAGE1 Sarcoma antigen 1 -4.5 NM_018666.1 B2M Beta-2-microglobulin -3.2 AU147899 IL13RA2 interleukin 13 receptor, alpha 2 -1.5 NM_000640.1