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Epidemiology 2016 Epidemiology 2016 FROM THE DEPARTMENT OF EPIDEMIOLOGY 2016 ANNUAL REPORT MAILMAN SCHOOL OF PUBLIC HEALTH – COLUMBIA UNIVERSITY Charles C. Branas, PhD Chair Department of Epidemiology EDITOR Kathryn Gerlach Assistant Manager for Communications CONTRIBUTING WRITERS Stephanie Berger Director of Communications for Media Relations, Mailman School of Public Health Timothy S. Paul Associate Director for Editorial Communications, Mailman School of Public Health DESIGNER Kristen Byers Web Developer / Graphic Designer table of contents Research highlights Symposium report 4 Humans vs. the mosquito: An age-old battle 21 Injuries, including those caused by guns, are preventable 5 New evidence on why young women in South Africa are at high risk of HIV infection Epidemiology by the numbers 6 The curious link between family size and height 22 EPIC: Registration growth by year 7 Wage gap may help explain why more women are 23 Supporting student research anxious and depressed than men 24 Fall 2016 incoming students 8 What’s the right prescription to end the opioid epidemic? 24 Epidemiology graduates: Employment outcomes 9 Marijuana use disorder is on the rise nationally; 25 Epidemiology graduates: Work type few receive treatment 10 Low maternal thyroid hormone increases In the news schizophrenia risk for offspring 26 U.S. suicide rate at 30-year high 11 Pre-diabetes may damage heart 27 The opioid epidemic 12 Health goes downhill when older adults stop driving 28 Gun violence in America 13 9/11-related illness still common 29 Other clips 14 Fruits and vegetables may slow ALS 15 Cancer expert says public health and prevention Bibliography measures are key to defeating cancer 30 Faculty publications Feature 16 The future of epidemiology 1 letter from the chair Colleagues, Welcome to Epidemiology 2016, the annual report for the Department of Epidemiology at the Columbia University Mailman School of Public Health. Having only just begun my new role as department chair it seems fitting that, in learning the full extent of my new colleagues’ many impres- sive achievements, I use this opportunity to share these with you as part of our yearly snapshot of science, training, and translation in the Department. For many years, I’ve reflected on the future of epidemiology as a front- line scientist—where we’ve been and where we should go, and I was greatly honored when Dr. Linda Fried, Mailman School Dean, invited me this past summer to share my thoughts on such a weighty topic. Epidemiology is, and should be seen as, a world-class science that impacts the lives of real people, in ways we can all appreciate. On page 16, I’ve elaborated on this in The Future of Epidemiology: World Class Science, Real World Impact, and it’s my hope that this principle will be one of the guideposts for the future of our Department. Dr. Guohua Li, to whom we owe a great debt for his stellar commitment as interim chair, wrote in last year’s annual report that the future of epidemiology seminar series would forge “a roadmap for ensuring our Department’s successful transition and continued growth in the years to come.” Indeed it has. I am eager to start on this exciting journey, and am confident that the Department of Epidemiology will continue to reach ever more impressive heights with its world class science, its production of next- generation scientific leaders, and its use of epidemiology as a powerful force for change in the world. Best regards for a great year, Charles C. Branas, PhD 3 research highlight here’s an old proverb: “If you think Controlling yellow fever: A victim you are too small to make a differ- of its own success ence, try spending the night with a T Immunization, paired with mosquito mosquito.” It’s an inspiring sentiment— control efforts, was so effective in the but of course the insects do far worse Western Hemisphere that yellow fever than ruin a single night’s sleep; they are was largely relegated to the history responsible for carrying and spreading books—a problem of the past. But some of the most lethal diseases in today, the world is seeing a resurgence human history. of yellow fever, and the other diseases “The Aedes aegypti mosquito is carried by the Aedes aegypti pose a notorious,” says Stephen Morse, pro- greater threat than ever. fessor of Epidemiology. “It carries a “In many parts of the world, the vac- family of viruses that have posed a cine is only made widely available when threat throughout history: yellow fever, you have an outbreak,” explains Morse. dengue, chikungunya, and—most “It’s been used not for prevention but recently—Zika.” Fortunately, humans do emergency response. have effective tools to fight theAedes aegypti and all the diseases it carries. Simultaneous battles: Yellow fever and Zika A brief history of yellow fever Compounding this problem is Of all the viruses carried by the another virus carried by the Aedes Aedes aegypti, yellow fever has his- aegypti: Zika. Until very recently, Zika torically been considered the most was considered mild, especially when dangerous due to its high fatality rate. compared with the fatality rate of Originating from West Africa, yellow yellow fever. But recently, scientists fever made its way across the Atlantic confirmed the connection between the Ocean with the slave trade, spreading virus and very severe birth defects. The across the Caribbean and the tropical top Aedes aegypti experts and vaccine Humans vs. the regions of North and South America. companies are working now to rapidly Throughout early American history, develop a vaccine for Zika. mosquito: An there were several deadly outbreaks For many in public health, the best of yellow fever, the worst of which hit way to tackle Zika and yellow fever lies age-old battle Philadelphia in 1793, killing an esti- not in vaccines, but in stepping up mos- mated 5,000 people—about 10 percent quito control efforts. The Aedes aegypti of the city’s population. Yellow fever is highly adaptable to human beings: it also posed such a deadly threat that bites during the day, it can breed in the related media coverage the very first attempts to build the tiniest amounts of water, and will often Panama Canal failed. Around the turn stay in or near homes. After World War ABC News of the 20th century, scientists proved II, many countries in South and North abcn.ws/2bsFplg two important facts to help fight yellow America dedicated extensive, effec- fever: mosquitoes could spread human tive—and very expensive efforts—to The Atlantic diseases—and yellow fever was carried control the mosquito, including the theatln.tc/1Zgn2zz by the Aedes aegypti mosquito. spraying of pesticides like DDT. These discoveries led to a break- “Mosquito control was a victim of Huffington Post through: in 1936, Max Theiler—who was its own success,” says Morse. “The huff.to/1UpZF4b awarded the Nobel Prize for his work— mosquito problem wasn’t as glaring, created the yellow fever vaccine. “The so the efforts weren’t sustained—and New York Times development of the vaccine was really a the mosquitoes came back. That’s the nyti.ms/2cawvca remarkable tour de force,” says Morse. irony in today’s Zika outbreak: if it had “That’s what tamed yellow fever for happened fifty years ago, we would most of the wealthy world. It’s one of probably be better off. The virus likely the oldest vaccines, but today it remains wouldn’t have been able to establish one of the safest, most effective vac- itself in South America, because the cines we have.” mosquito had been largely controlled.” 4 2016 ANNUAL REPORT research highlight vidence by the Centre for the “Reducing new HIV infections in AIDS Programme of Research young women is one of the greatest Ein South Africa (CAPRISA) challenges in southern Africa,” com- consortium of South African and North mented Dr. Abdool Karim. American researchers was presented The three studies provide scien- at the International AIDS 2016 tific evidence, using state-of-the-art Conference in Durban, shedding new research technologies, to guide tar- light on why young women in South geted HIV prevention interventions to Africa have high rates of HIV infection. break the cycle of HIV transmission Dr. Salim Abdool Karim, professor of and impact the course of HIV in South Epidemiology at Columbia University’s Africa and potentially in other high Mailman School of Public Health and burden settings. Since the Prevotella director of CAPRISA, led the research and Gardnerella bacteria raise the team. The Mailman School was also vaginal pH, a readily available, quick, among the North American institutions simple and cheap test can be used providing research support. to ascertain which women require In a study of 9,812 individuals, the treatment for bacterial vaginosis, an genetic code of HIV from each of 1,589 imbalance in the vaginal bacteria. Com- HIV-positive people was analyzed bined, these interventions could have a to better understand the relentless significant impact on the spread of HIV spread of HIV in a rural and urban in women in South Africa and beyond. community in South Africa. It revealed Dr Margaret Chan, Director-Gen- a “cycle of HIV transmission” driven eral, World Health Organization, by high rates of new HIV infections in commented that, “Young women in adolescent girls and young women Africa have missed out while others from men, on average 8 years older. have benefitted from global progress Many of these men were also partners against AIDS. The new studies point of similarly aged women who have HIV the way to HIV prevention oppor- New evidence prevalence rates exceeding 60%. tunities that can help rectify this A second study, led by Dr.
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