The Royal Society of Edinburgh Review 2005 (Session 2003-2004)
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Old Joe Autumn 2015
OLDJOETHE UNIVERSITY OF BIRMINGHAM’S ALUMNI AND FRIENDS MAGAZINE Autumn 2015 The time lords Giving birth to hope Creativity close up 2 OLD JOE THE FIRST WORD The firstword This special edition of Old Joe magazine celebrates something truly extraordinary; GUEST EDITOR the University’s pioneering Circles of Influence fundraising campaign raising Each year Birmingham has many an astounding £193,426,877.47 million. reasons to celebrate, and this year Circles of Influence substantially has been no different. The Circles exceeded its £160 million target to of Influence campaign has officially become the largest charitable campaign raised £193.4 million, funding outside Oxford, London, and Cambridge, extraordinary projects on campus, and this was only possible through the locally and globally (page 8). kindness and generosity of our donors I am honoured to represent the and volunteers. University by graduating as its From completing the Aston Webb semi-circle with the Bramall Music Building symbolic 300,000th alumna (page to funding life-saving cancer research, the campaign has left a wonderful legacy 36). Being part of this momentous to the University and the impact of donors’ gifts will be felt for years to come. From occasion has been a fantastic way to our very conception as England’s first civic university more than a century ago, end my three years as an Birmingham has been founded through philanthropy and our donors’ generosity is undergraduate. I have thoroughly keeping that vision strong. enjoyed my time here. Inside this magazine, you can read how our extraordinary campaign has changed During my final year I was treasurer thousands of people’s lives, and learn more about some of the exciting new areas of the Women in Finance society, so addressing society’s biggest challenges where our fundraising will now focus, it was inspiring to read alumna Billie from saving mothers’ lives in Africa to innovative new cancer treatments. -
Cairncross Review a Sustainable Future for Journalism
THE CAIRNCROSS REVIEW A SUSTAINABLE FUTURE FOR JOURNALISM 12 TH FEBRUARY 2019 Contents Executive Summary 5 Chapter 1 – Why should we care about the future of journalism? 14 Introduction 14 1.1 What kinds of journalism matter most? 16 1.2 The wider landscape of news provision 17 1.3 Investigative journalism 18 1.4 Reporting on democracy 21 Chapter 2 – The changing market for news 24 Introduction 24 2.1 Readers have moved online, and print has declined 25 2.2 Online news distribution has changed the ways people consume news 27 2.3 What could be done? 34 Chapter 3 – News publishers’ response to the shift online and falling revenues 39 Introduction 39 3.1 The pursuit of digital advertising revenue 40 Case Study: A Contemporary Newsroom 43 3.2 Direct payment by consumers 48 3.3 What could be done 53 Chapter 4 – The role of the online platforms in the markets for news and advertising 57 Introduction 57 4.1 The online advertising market 58 4.2 The distribution of news publishers’ content online 65 4.3 What could be done? 72 Cairncross Review | 2 Chapter 5 – A future for public interest news 76 5.1 The digital transition has undermined the provision of public-interest journalism 77 5.2 What are publishers already doing to sustain the provision of public-interest news? 78 5.3 The challenges to public-interest journalism are most acute at the local level 79 5.4 What could be done? 82 Conclusion 88 Chapter 6 – What should be done? 90 Endnotes 103 Appendix A: Terms of Reference 114 Appendix B: Advisory Panel 116 Appendix C: Review Methodology 120 Appendix D: List of organisations met during the Review 121 Appendix E: Review Glossary 123 Appendix F: Summary of the Call for Evidence 128 Introduction 128 Appendix G: Acknowledgements 157 Cairncross Review | 3 Executive Summary Executive Summary “The full importance of an epoch-making idea is But the evidence also showed the difficulties with often not perceived in the generation in which it recommending general measures to support is made.. -
A Novel Optical Microscope for Imaging Large
RESEARCH ARTICLE A novel optical microscope for imaging large embryos and tissue volumes with sub-cellular resolution throughout Gail McConnell1*, Johanna Tra¨ ga˚ rdh1, Rumelo Amor1, John Dempster1, Es Reid1, William Bradshaw Amos1,2 1Centre for Biophotonics, Strathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom; 2MRC Laboratory of Molecular Biology, Cambridge, United Kingdom Abstract Current optical microscope objectives of low magnification have low numerical aperture and therefore have too little depth resolution and discrimination to perform well in confocal and nonlinear microscopy. This is a serious limitation in important areas, including the phenotypic screening of human genes in transgenic mice by study of embryos undergoing advanced organogenesis. We have built an optical lens system for 3D imaging of objects up to 6 mm wide and 3 mm thick with depth resolution of only a few microns instead of the tens of microns currently attained, allowing sub-cellular detail to be resolved throughout the volume. We present this lens, called the Mesolens, with performance data and images from biological specimens including confocal images of whole fixed and intact fluorescently-stained 12.5-day old mouse embryos. DOI: 10.7554/eLife.18659.001 Introduction During experiments with laser scanning confocal microscopes in the mid-1980s, it became obvious that the optical sectioning, which is the main advantage of the confocal method, did not work with *For correspondence: the available low-magnification objectives, because of their low numerical aperture (N.A.) [email protected] (White et al., 1987). In specimens such as mouse embryos at the 10–12.5 day stage, when the major Competing interest: See organs are developing (Kaufman, 1992), it was impossible to see individual cells in the interior page 14 despite the lateral (XY) resolution being sufficient. -
THE NEWZOOM Does Journalism Need Offices? Contents
MAGAZINE OF THE NATIONAL UNION OF JOURNALISTS WWW.NUJ.ORG.UK | OCTOBER-NOVEMBER 2020 THE NEWZOOM Does journalism need offices? Contents Main feature 12 News from the home front Is the end of the office nigh? News he coronavirus pandemic is changing 03 Thousands of job cuts take effect the way we live and work radically. Not least among the changes is our Union negotiates redundancies widespread working from home and 04 Fury over News UK contracts the broader question of how much we Photographers lose rights Tneed an office. Some businesses are questioning whether they need one at all, others are looking 05 Bullivant strike saves jobs towards a future of mixed working patterns with some Management enters into talks homeworking and some office attendance. In our cover feature 06 TUC Congress Neil Merrick looks at what this means for our industry. Reports from first virtual meeting Also in this edition of The Journalist we have a feature on how virtual meetings are generating more activity in branches “because the meetings are now more accessible. Edinburgh Features Freelance branch has seen a big jump in people getting 10 Behind closed doors involved, has increased the frequency of its meetings and has Reporting the family courts linked up with other branches for joint meetings. Recently, the TUC held its first virtual conference. We have full 14 News takes centre stage coverage of the main issues and those raised by the NUJ. Media takes to innovative story telling As we work from home there’s growing evidence of a revival 21 Saving my A&E in the local economy and a strengthening of the high street A sharp PR learning curve which not that long ago was suffering as consumers opted for large out of town centres. -
A Novel Optical Microscope for Imaging Large Embryos And
RESEARCH ARTICLE A novel optical microscope for imaging large embryos and tissue volumes with sub-cellular resolution throughout Gail McConnell1*, Johanna Tra¨ ga˚ rdh1, Rumelo Amor1, John Dempster1, Es Reid1, William Bradshaw Amos1,2 1Centre for Biophotonics, Strathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom; 2MRC Laboratory of Molecular Biology, Cambridge, United Kingdom Abstract Current optical microscope objectives of low magnification have low numerical aperture and therefore have too little depth resolution and discrimination to perform well in confocal and nonlinear microscopy. This is a serious limitation in important areas, including the phenotypic screening of human genes in transgenic mice by study of embryos undergoing advanced organogenesis. We have built an optical lens system for 3D imaging of objects up to 6 mm wide and 3 mm thick with depth resolution of only a few microns instead of the tens of microns currently attained, allowing sub-cellular detail to be resolved throughout the volume. We present this lens, called the Mesolens, with performance data and images from biological specimens including confocal images of whole fixed and intact fluorescently-stained 12.5-day old mouse embryos. DOI: 10.7554/eLife.18659.001 Introduction During experiments with laser scanning confocal microscopes in the mid-1980s, it became obvious *For correspondence: that the optical sectioning, which is the main advantage of the confocal method, did not work with [email protected] the available low-magnification objectives, because of their low numerical aperture (N.A.) Competing interest: See (White et al., 1987). In specimens such as mouse embryos at the 10–12.5 day stage, when the major page 14 organs are developing (Kaufman, 1992), it was impossible to see individual cells in the interior despite the lateral (XY) resolution being sufficient. -
April 2000 – February 2001)
U.S. Commission on National Security/21st Century (click on heading to be linked directly to that section) Phase 1 (July 1998 - August 1999) Major Themes And Implications Supporting Research And Analysis Phase 2 (August 2000 – April 2000) Seeking A National Strategy: A Concert For Preserving Security And Promoting Freedom Phase 3 (April 2000 – February 2001) Roadmap For National Security: Imperative For Change 71730_DAPS.qx 10/12/99 5:06 PM Page #1 NEW WORLD COMING: AMERICAN SECURITY IN THE 21ST CENTURY MAJOR THEMES AND IMPLICATIONS The Phase I Report on the Emerging Global Security Environment for the First Quarter of the 21st Century The United States Commission on National Security/21st Century September 15, 1999 71730_DAPS.qx 10/12/99 5:06 PM Page #3 Preface In 1947, President Harry Truman signed into law the National Security Act, the landmark U.S. national security legislation of the latter half of the 20th century. The 1947 legislation has served us well. It has undergirded our diplomatic efforts, provided the basis to establish our military capa- bilities, and focused our intelligence assets. But the world has changed dramatically in the last fifty years, and particularly in the last decade. Institutions designed in another age may or may not be appropriate for the future. It is the mandate of the United States Commission on National Security/21st Century to examine precise- ly that question. It has undertaken to do so in three phases: the first to describe the world emerging in the first quarter of the next century, the second to design a national security strategy appropri- ate to that world, and the third to propose necessary changes to the national security structure in order to implement that strategy effectively. -
Exeter Excelling a Celebration of Success Message from the Rector Professor Sir Rick Trainor
EXETER EXCELLING A CELEBRATION OF SUCCESS MESSAGE FROM THE RECTOR PROFESSOR SIR RICK TRAINOR leap forwards in securing xeter’s future It is with great honour and pleasure that I can announce, with gratitude to the whole Exeter community, that we have exceeded our goal of raising £45 million over the last 10 years. The Exeter Excelling campaign was launched in 2006 and, over the period leading up to our 700th anniversary in 2014 – and a little beyond – we have received support on a scale that has never before been achieved by an Oxford college. With over 4,000 alumni making a gift in this period, and support also from parents, friends, Fellows, staff and even current students, we have leapt forwards in securing Exeter’s future as it enters its eighth century. Your support has created an entirely new quadrangle for this and future generations of Exonians – the biggest single expansion of the College since its earliest years. In addition you have secured tutorial teaching and made study at Oxford an affordable option for the brightest young minds in the UK and around the world. Thank you for what you’ve done as a member of this family: for your friendship, your support, your guidance, and most of all for your passion in seeing Exeter excel. In celebrating these achievements, I know you will join with me in giving substantial credit and heartfelt thanks to Rector Frances Cairncross whose vision and leadership brought this Campaign, and indeed Cohen Quad, into existence. I have very much inherited the success that her endeavours, for which we are all grateful, have brought about. -
Simvastatin Causes Pulmonary Artery Relaxation by Blocking Smooth Muscle ROCK and Calcium Channels: Evidence for an Endothelium-Independent Mechanism
RESEARCH ARTICLE Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels: Evidence for an endothelium-independent mechanism 1,2 1,3 1 1 1 Mais Absi , Basma G. Eid , Nick Ashton , George Hart , Alison M. GurneyID * 1 Faculty of Biology Medicine and Health, University of Manchester, Core Technology Facility level, a1111111111 Manchester, United Kingdom, 2 Cardiovascular Sciences, Kings College London, London, United Kingdom, 3 Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, a1111111111 Saudi Arabia a1111111111 a1111111111 * [email protected] a1111111111 Abstract Simvastatin reduces pulmonary arterial pressure and right ventricular hypertrophy in animal OPEN ACCESS models of pulmonary arterial hypertension (PAH) and is thought to restore endothelial dys- Citation: Absi M, Eid BG, Ashton N, Hart G, Gurney function. In vivo effects of drugs are complicated by several factors and little is known of the AM (2019) Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and direct effects of statins on pulmonary arteries. This study investigated the direct effects of calcium channels: Evidence for an endothelium- simvastatin on pulmonary arteries isolated from rats with or without monocrotaline-induced independent mechanism. PLoS ONE 14(8): PAH. Simvastatin suppressed contractions evoked by the thromboxane A2 receptor agonist e0220473. https://doi.org/10.1371/journal. U46619 (30 nM), the α ±adrenergic agonist phenylephrine (5 μM) and KCl (50 mM) by pone.0220473 1 ~50% in healthy and diseased arteries, but did not reduce contraction evoked by sarco/ Editor: Alexander G. Obukhov, Indiana University endoplasmic reticulum ATPase blockers. It relaxed hypertensive arteries in the absence of School of Medicine, UNITED STATES stimulation. -
Physiologynews
PHYSIOLOGYNEWS winter 2005 | number 61 Meetings UCL Images of Oxford Bristol revisited Also featuring: Physiology in space Richard Naftalin’s ‘desert island’ selection Cutting through the melatonin hype Reflections of a ex-Chair Letter from Russia What turned us on to physiology Winter books special A publication of The Physiological Society OXFORD FOCUSED MEETING Ion channels, genes and regulation in smooth muscle 5-7 September 2005 More photos and a report from the Oxford Focused Meeting appear on p. 5 (photos by Prem Kumar and Roger Thomas) PHYSIOLOGYNEWS Editorial 3 Movement neuroscience at UCL Philip Harrison 4 Ion channels, genes and regulation in smooth The Society’s dog. ‘Rudolf Magnus gave muscle David Beech, Anant Parekh, Phil Aaronson 5 me to Charles Sherrington, who gave me ‘Stan-power’ 7 to Henry Dale, who gave me to the Judy Harris Physiological Society in October 1942’ Bristol revisited Austin Elliott 8 My 10 key papers 10 My top 10 papers on biological salt, water and sugar transport Published quarterly by the Physiological Society Richard Naftalin Contributions and Queries Executive Editor A week in the life of... 14 Linda Rimmer A short month in the life of the Vice Chair Ian McGrath The Physiological Society Publications Office P.O. Box 502 What turned me on to physiology? Thelma Lovick, 15 Cambridge CB1 0AL UK Bill Winlow, Austin Elliott Tel: +44 (0)1223 400180 Letter from...Russia Evgeny Nikolsky, Ellya Bukharaeva 17 Fax: +44 (0)1223 246858 Email: [email protected] The Society web server: http://www.physoc.org Physiology -
Who, Where and When: the History & Constitution of the University of Glasgow
Who, Where and When: The History & Constitution of the University of Glasgow Compiled by Michael Moss, Moira Rankin and Lesley Richmond © University of Glasgow, Michael Moss, Moira Rankin and Lesley Richmond, 2001 Published by University of Glasgow, G12 8QQ Typeset by Media Services, University of Glasgow Printed by 21 Colour, Queenslie Industrial Estate, Glasgow, G33 4DB CIP Data for this book is available from the British Library ISBN: 0 85261 734 8 All rights reserved. Contents Introduction 7 A Brief History 9 The University of Glasgow 9 Predecessor Institutions 12 Anderson’s College of Medicine 12 Glasgow Dental Hospital and School 13 Glasgow Veterinary College 13 Queen Margaret College 14 Royal Scottish Academy of Music and Drama 15 St Andrew’s College of Education 16 St Mungo’s College of Medicine 16 Trinity College 17 The Constitution 19 The Papal Bull 19 The Coat of Arms 22 Management 25 Chancellor 25 Rector 26 Principal and Vice-Chancellor 29 Vice-Principals 31 Dean of Faculties 32 University Court 34 Senatus Academicus 35 Management Group 37 General Council 38 Students’ Representative Council 40 Faculties 43 Arts 43 Biomedical and Life Sciences 44 Computing Science, Mathematics and Statistics 45 Divinity 45 Education 46 Engineering 47 Law and Financial Studies 48 Medicine 49 Physical Sciences 51 Science (1893-2000) 51 Social Sciences 52 Veterinary Medicine 53 History and Constitution Administration 55 Archive Services 55 Bedellus 57 Chaplaincies 58 Hunterian Museum and Art Gallery 60 Library 66 Registry 69 Affiliated Institutions -
KV7 Potassium Channels: a Focus on Human Intra-Pulmonary Arteries
KV7 potassium channels: A focus on human intra-pulmonary arteries A thesis submitted to the University of Manchester for the degree of Doctor of Philosophy in the Faculty of Life Sciences 2015 Sean Brennan 1 List of contents Chapter 1 : Introduction ........................................................................................................ 15 1.1 Anatomy and physiology of the lungs .......................................................................... 15 1.2 Pulmonary artery structure ......................................................................................... 15 1.3 Pulmonary hypertension .............................................................................................. 16 1.3.1 Definition .............................................................................................................. 16 1.3.2 Characteristics ....................................................................................................... 17 1.3.3 Classification ......................................................................................................... 17 1.3.4 Treatment ............................................................................................................. 19 1.4 Regulation of the pulmonary vasculature.................................................................... 21 1.4.1 Neuronal regulation .............................................................................................. 21 1.4.2 Humoral regulation .............................................................................................. -
QUARTERLY BULLETIN Contents
THE BRITISH SOCIETY FOR CARDIOVASCULAR RESEARCH QUARTERLY BULLETIN July 1996 Volume 9 No. 3 Contents Editorial 3 BSCR Events Diary i 3 Secretary's Column 4 BSCR Workshop Report The Experimental and Therapeutic Gene Transfer and Antisense Strategies for Cardiovascular Disease 5 Meeting Report First Joint National Vascular Meeting: Diabetic Angiopathy 6 Job Advert Postdoctoral Electrophysiologist 7 Forthcoming Meetings 7' Nominations for BSCR Committee 8 Software Review: Cellular Mechanisms in Cardiac Physiology Functional Anatomy of the Heart 10 BSCR Quarterly Bulletin Deadlines 11 British Heart Foundation Awards January/June 1996 12 BSCR Autumn Meeting Poster Mediators in Cardiovascular Disease 20 Registered Charity Number: 1011141 Supported by an educational grant from: CARDIOVASCULAR THE BRITISH SOCIETY FOR CARDIOVASCULAR RESEARCH Quarterly Bulletin Editors Committee Dr T. Jeff Allen Dr. Gary F Baxter Department of Pharmacology The Hatter Institute of Cardiovascular Studies Royal Free Hospital School of Medicine Department of Academic & Clinical Cardiology Rowland Hill Street University College Hospital London NW3 2PF Grafton Way Tel. 0171-794 0500 ext. 5751 London WCIE 6DB Fax. 0171-794 6854 Tel: 0171 380 9888 e-mail: [email protected] Fax: 0171 388 5095 e-mail: [email protected] Dr Kathryn O. Ryder Department of Cardiovascular Medicine Dr. Michael J Curtis John Radcliffe Hospital, Oxford OX3 9DU Pharmacology Group Tel. 01865-220 428/136 Biomedical Siences Division Fax. 01865-221 977 Kings College London e-mail: [email protected] Manresa Road London SW3 6LX Chairman Dr Peter Cummins Dr. Suzanna Hardman Dept. of Physiology Hatter Institute of Cardiovascular Studies Molecular Cardiology Unit University College London Medical School The Medical School, University of Birmingham Grafton Way Birmingham B15 2TJ London WCl 6DB Tel: 0121-414 6896 Tel.